ATE302175T1 - Verfahren zur herstellung von (18f) radiomarkierten nitroimidazol-derivaten zum nachweis zellulärer hypoxie - Google Patents

Verfahren zur herstellung von (18f) radiomarkierten nitroimidazol-derivaten zum nachweis zellulärer hypoxie

Info

Publication number
ATE302175T1
ATE302175T1 AT00936775T AT00936775T ATE302175T1 AT E302175 T1 ATE302175 T1 AT E302175T1 AT 00936775 T AT00936775 T AT 00936775T AT 00936775 T AT00936775 T AT 00936775T AT E302175 T1 ATE302175 T1 AT E302175T1
Authority
AT
Austria
Prior art keywords
sup
labelled
patient
relates
present
Prior art date
Application number
AT00936775T
Other languages
English (en)
Inventor
Jacqueline Marchand
Vincent Gregoire
Original Assignee
Univ Catholique Louvain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Catholique Louvain filed Critical Univ Catholique Louvain
Application granted granted Critical
Publication of ATE302175T1 publication Critical patent/ATE302175T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00936775T 1999-08-11 2000-05-22 Verfahren zur herstellung von (18f) radiomarkierten nitroimidazol-derivaten zum nachweis zellulärer hypoxie ATE302175T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99870172 1999-08-11
PCT/EP2000/004632 WO2001012575A1 (en) 1999-08-11 2000-05-22 Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection

Publications (1)

Publication Number Publication Date
ATE302175T1 true ATE302175T1 (de) 2005-09-15

Family

ID=8243882

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00936775T ATE302175T1 (de) 1999-08-11 2000-05-22 Verfahren zur herstellung von (18f) radiomarkierten nitroimidazol-derivaten zum nachweis zellulärer hypoxie

Country Status (9)

Country Link
US (1) US7108846B1 (de)
EP (1) EP1202945B1 (de)
JP (1) JP2003507354A (de)
AT (1) ATE302175T1 (de)
AU (1) AU5215100A (de)
CA (1) CA2378712A1 (de)
DE (1) DE60022058T2 (de)
ES (1) ES2246858T3 (de)
WO (1) WO2001012575A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
DE102005063244A1 (de) * 2005-12-21 2007-06-28 Eberhard-Karls-Universität Tübingen Modifiziertes 2-Nitroimidazol-Derivat
US7998031B2 (en) * 2006-09-28 2011-08-16 Sharon Dumke Exercise device for aquatic use
CA2683433C (en) 2007-04-05 2016-10-11 Siemens Medical Solutions Usa, Inc. Nitro-imidazole hypoxia imaging agents
US20110065914A1 (en) * 2007-08-29 2011-03-17 Bengt Langstrom Perfluoro macrocycles in 18f-labelling of macromolecules
US20090117607A1 (en) * 2007-11-01 2009-05-07 Koch Cameron J Methods For Differential Detection Of Hypoxic Tissue From A Tissue Sample Of A Mammalian Subject
US8686158B2 (en) * 2008-06-05 2014-04-01 President And Fellows Of Harvard College High-valent palladium fluoride complexes and uses thereof
KR20110095898A (ko) 2008-11-20 2011-08-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 유기 화합물의 플루오르화
CA2749317A1 (en) * 2009-01-09 2010-07-15 President And Fellows Of Harvard College Fluorine containing compounds and methods of use thereof
WO2011052522A1 (ja) * 2009-10-26 2011-05-05 富士フイルムＲｉファーマ株式会社 感染症診断薬
US9150516B2 (en) 2011-04-12 2015-10-06 President And Fellows Of Harvard College Fluorination of organic compounds
US9273083B2 (en) 2012-09-26 2016-03-01 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
US10759764B2 (en) 2013-10-18 2020-09-01 President And Fellows Of Harvard College Fluorination of organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532755A (en) * 1965-08-03 1970-10-06 Du Pont Hydrogenation of perfluoroalkyl nitriles
DE69332741T2 (de) * 1992-11-19 2003-10-02 The University Of Rochester, Rochester Nachweis von hypoxia
AU8074294A (en) 1993-10-04 1995-05-01 Board Of Regents, The University Of Texas System Rapid synthesis and use of 18f-fluoromisonidazole and analogs

Also Published As

Publication number Publication date
WO2001012575A1 (en) 2001-02-22
JP2003507354A (ja) 2003-02-25
DE60022058T2 (de) 2006-06-01
AU5215100A (en) 2001-03-13
ES2246858T3 (es) 2006-03-01
US7108846B1 (en) 2006-09-19
CA2378712A1 (en) 2001-02-22
EP1202945B1 (de) 2005-08-17
DE60022058D1 (de) 2005-09-22
EP1202945A1 (de) 2002-05-08

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