DE69933518D1 - Stabile flüssige zusammensetzungen von kalzium-ascorbat und verfahren zu ihrer herstellung und verwendung - Google Patents

Stabile flüssige zusammensetzungen von kalzium-ascorbat und verfahren zu ihrer herstellung und verwendung

Info

Publication number
DE69933518D1
DE69933518D1 DE69933518T DE69933518T DE69933518D1 DE 69933518 D1 DE69933518 D1 DE 69933518D1 DE 69933518 T DE69933518 T DE 69933518T DE 69933518 T DE69933518 T DE 69933518T DE 69933518 D1 DE69933518 D1 DE 69933518D1
Authority
DE
Germany
Prior art keywords
compound
concentrate
ascorbate
solvent
pharmacologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69933518T
Other languages
English (en)
Other versions
DE69933518T2 (de
Inventor
C Hegenauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
THE ESTER C COMPANY, PRESCOTT, ARIZ., US
Original Assignee
ZILA NUTRACEUTICALS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZILA NUTRACEUTICALS Inc filed Critical ZILA NUTRACEUTICALS Inc
Application granted granted Critical
Publication of DE69933518D1 publication Critical patent/DE69933518D1/de
Publication of DE69933518T2 publication Critical patent/DE69933518T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE69933518T 1998-02-06 1999-02-05 Stabile flüssige zusammensetzungen von kalzium-ascorbat und verfahren zu ihrer herstellung und verwendung Expired - Lifetime DE69933518T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/US98/02333 1998-02-06
US9802333 1998-02-06
PCT/US1999/002735 WO1999039580A1 (en) 1998-02-06 1999-02-05 Stable liquid mineral ascorbate compositions and methods of manufacture and use

Publications (2)

Publication Number Publication Date
DE69933518D1 true DE69933518D1 (de) 2006-11-23
DE69933518T2 DE69933518T2 (de) 2007-08-23

Family

ID=22266349

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69933518T Expired - Lifetime DE69933518T2 (de) 1998-02-06 1999-02-05 Stabile flüssige zusammensetzungen von kalzium-ascorbat und verfahren zu ihrer herstellung und verwendung

Country Status (19)

Country Link
US (1) US6197813B1 (de)
EP (1) EP0982990B1 (de)
JP (1) JP4717166B2 (de)
KR (1) KR100636991B1 (de)
CN (1) CN1256943C (de)
AT (1) ATE341938T1 (de)
AU (1) AU744584B2 (de)
CA (1) CA2275420C (de)
DE (1) DE69933518T2 (de)
DK (1) DK0982990T3 (de)
ES (1) ES2274618T3 (de)
HK (1) HK1028323A1 (de)
IS (1) IS2560B (de)
NO (1) NO328336B1 (de)
NZ (1) NZ336188A (de)
PT (1) PT982990E (de)
TR (1) TR199902482T1 (de)
TW (1) TWI227138B (de)
WO (1) WO1999039580A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001280448B8 (en) * 1998-01-05 2008-05-29 The Ester C Company Vitamin C Compositions
US6878744B2 (en) * 1999-02-05 2005-04-12 Oxycal Laboratories, Inc. Vitamin C compositions
US20040266673A1 (en) * 2002-07-31 2004-12-30 Peter Bakis Long lasting natriuretic peptide derivatives
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
WO2001015692A1 (en) * 1999-08-30 2001-03-08 Oxycal Laboratories, Inc. Methods and compositions for selective cancer chemotherapy
CN1189159C (zh) * 2000-05-05 2005-02-16 欧莱雅 含水溶性美容活性组分水性核的微胶囊及含其的组合物
US6468980B1 (en) * 2000-09-01 2002-10-22 Oxycal Laboratories, Inc. Methods and compositions for potentiating cancer chemotherapeutic agents
JP2002265347A (ja) * 2001-03-13 2002-09-18 Shiseido Co Ltd コーニファイドエンベロープの成熟を促す化粧料
EP2859894A1 (de) 2001-06-26 2015-04-15 The Ester C Company Vitamin-C-Zuammensetzungen
DE10158447B4 (de) 2001-11-30 2005-02-10 Aquanova German Solubilisate Technologies (Agt) Gmbh Ascorbinsäure-Solubilisat
US8975295B2 (en) * 2002-10-25 2015-03-10 Precision Dermatology, Inc. Modulation of zinc levels to improve tissue properties
EP1616486A1 (de) * 2004-07-13 2006-01-18 Friesland Brands B.V. Pulver Zubereitungen enthaltend ein essbares Öl, und deren Verwendung in Lebensmitteln
US20070269534A1 (en) * 2006-02-02 2007-11-22 Ramirez Jose E Methods of treating skin to enhance therapeutic treatment thereof
CA2575398C (en) * 2006-02-02 2011-12-20 Omp, Inc. Methods of treating skin to enhance therapeutic treatment thereof
ITTO20060782A1 (it) * 2006-11-02 2008-05-03 Mb Med S R L Procedimento per la preparazione di acido ascorbico o un suo sale da matrici vegetali
US20090099074A1 (en) * 2007-01-10 2009-04-16 Conjuchem Biotechnologies Inc. Modulating food intake
US7794585B2 (en) * 2007-10-15 2010-09-14 Uop Llc Hydrocarbon conversion process
JP5586713B2 (ja) * 2013-01-21 2014-09-10 サンエイ糖化株式会社 ミネラル可溶化安定剤
US10806692B2 (en) 2016-10-03 2020-10-20 The Procter & Gamble Company Skin cleansing compositions comprising color stable abrasive particles
CN110151577A (zh) * 2019-06-18 2019-08-23 上海宜侬生物科技有限公司 含有l-抗坏血酸的化妆品组成物
CN111679000A (zh) * 2020-05-29 2020-09-18 费森尤斯卡比华瑞制药有限公司 检测肠内或肠外营养制剂中维生素c杂质的方法
US20230048204A1 (en) * 2021-08-12 2023-02-16 Jiayin BAO Skincare product and multi-dimensional ascorbic acid serum formulation therefor

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2400171A (en) * 1935-09-26 1946-05-14 Frances R Ruskin Stabilized metal ascorbates
US2585580A (en) * 1947-06-12 1952-02-12 Opplt Jan Stabilizing ascorbic acid with thio-sugars
US2822317A (en) * 1955-12-12 1958-02-04 Smith Kline French Lab Aqueous iron-ascorbic acid preparation
JPS6270309A (ja) * 1985-09-24 1987-03-31 Kanebo Ltd 美白化粧料
US4968716A (en) * 1987-04-10 1990-11-06 Oxycal Laboratories, Inc. Compositions and methods for administering therapeutically active compounds
AU2228888A (en) * 1987-10-14 1989-05-25 Takeda Chemical Industries Ltd. Aqueous pharmaceutical preparation for oral administration
US5173214A (en) * 1989-02-01 1992-12-22 Union Oil Company Of California Precursor composition for sols and gels
JP2977865B2 (ja) * 1989-06-23 1999-11-15 三省製薬株式会社 真皮部位に発症する色素沈着症治療剤
JPH04235925A (ja) * 1991-01-11 1992-08-25 Otsuka Pharmaceut Co Ltd 安定な総合ビタミン注射液
KR920019370A (ko) * 1991-04-26 1992-11-19 스야마 다다카즈 주입 제제
JPH04346926A (ja) * 1991-05-21 1992-12-02 Sumitomo Pharmaceut Co Ltd シロップ剤
US5696169A (en) * 1992-03-13 1997-12-09 Otsuka Pharmaceutical Co., Ltd. Antibacterial and antifungal activity method, therapeutic method of infectious diseases and preserving method of cosmetics
JP2654529B2 (ja) * 1992-03-27 1997-09-17 大塚製薬株式会社 健康飲料組成物
JPH0630746A (ja) * 1992-07-10 1994-02-08 Kanebo Ltd アスコルビン酸含有食品の安定化方法
CA2176743A1 (en) * 1993-11-27 1995-06-01 Brian Christopher Challis Compositions comprising iminium ion scavengers and/or nitrite scavengers
US5968533A (en) * 1994-11-15 1999-10-19 Porter; Steven S. Skin care compositions and methods
JP3483988B2 (ja) * 1995-06-01 2004-01-06 株式会社資生堂 皮膚外用剤
JPH0967254A (ja) * 1995-09-01 1997-03-11 Yoshihide Hagiwara 安定化されたビタミンc組成物
DE69637277T2 (de) * 1995-10-17 2008-05-08 Showa Denko K.K. Hochreine tocopherolphosphate, verfahren zu ihrer herstellung und analyse, und kosmetika
JP3354768B2 (ja) * 1995-10-24 2002-12-09 カネボウ株式会社 皮膚化粧料
FR2742987B1 (fr) * 1996-01-03 1998-04-03 Lvmh Rech Utilisation dans le domaine de la cosmetique et de la pharmacie, notamment de la dermatologie, d'un extrait d'eriobotrya japonica pour stimuler la synthese des glycosaminoglycanes
US5906811A (en) * 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations

Also Published As

Publication number Publication date
CA2275420A1 (en) 1999-08-06
ES2274618T3 (es) 2007-05-16
JP4717166B2 (ja) 2011-07-06
AU2664799A (en) 1999-08-23
EP0982990B1 (de) 2006-10-11
NO994844L (no) 1999-10-05
HK1028323A1 (en) 2001-02-16
EP0982990A1 (de) 2000-03-08
EP0982990A4 (de) 2001-05-16
NO994844D0 (no) 1999-10-05
AU744584B2 (en) 2002-02-28
DE69933518T2 (de) 2007-08-23
CN1255829A (zh) 2000-06-07
KR100636991B1 (ko) 2006-10-23
CA2275420C (en) 2007-05-29
NO328336B1 (no) 2010-02-01
CN1256943C (zh) 2006-05-24
IS2560B (is) 2009-11-15
DK0982990T3 (da) 2007-02-12
US6197813B1 (en) 2001-03-06
TR199902482T1 (xx) 2002-10-21
TWI227138B (en) 2005-02-01
PT982990E (pt) 2007-01-31
KR20010006081A (ko) 2001-01-15
NZ336188A (en) 2000-03-27
JP2002513426A (ja) 2002-05-08
ATE341938T1 (de) 2006-11-15
IS5150A (is) 1999-08-06
WO1999039580A1 (en) 1999-08-12

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: THE ESTER C COMPANY, PRESCOTT, ARIZ., US

8364 No opposition during term of opposition