MX2010002448A - Formulacion liquida del g-csf conjugado. - Google Patents

Formulacion liquida del g-csf conjugado.

Info

Publication number
MX2010002448A
MX2010002448A MX2010002448A MX2010002448A MX2010002448A MX 2010002448 A MX2010002448 A MX 2010002448A MX 2010002448 A MX2010002448 A MX 2010002448A MX 2010002448 A MX2010002448 A MX 2010002448A MX 2010002448 A MX2010002448 A MX 2010002448A
Authority
MX
Mexico
Prior art keywords
composition
salts
stimulating factor
colony stimulating
granulocyte colony
Prior art date
Application number
MX2010002448A
Other languages
English (en)
Inventor
Walter Hinderer
Christian Scheckermann
Original Assignee
Biogenerix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenerix Ag filed Critical Biogenerix Ag
Publication of MX2010002448A publication Critical patent/MX2010002448A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer

Abstract

La presente invención se relaciona con una composición farmacéutica líquida que comprende un polipéptido del factor estimulador de colonias de granulocitos conjugado con un polímero, la composición tiene un valor de pH en la variación de 4.5 a 5.5. La composición comprende además un tensioactivo y opcionalmente uno o más de otros excipientes farmacéuticamente aceptables. Además, la composición de la invención está libre de ácido tartárico o las sales del mismo y de ácido succínico o. las sales del mismo como agentes amortiguadores y no contiene aminoácidos como estabilizante. La composición tiene una buena estabilidad en almacenamiento y es especialmente útil para la profilaxis y tratamiento de trastornos e indicaciones médicas donde se consideran como remedios útiles las preparaciones del factor estimulador de colonias de granulocitos.
MX2010002448A 2007-08-27 2008-08-27 Formulacion liquida del g-csf conjugado. MX2010002448A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07115047 2007-08-27
PCT/EP2008/061232 WO2009027437A1 (en) 2007-08-27 2008-08-27 Liquid formulation of g-csf conjugate

Publications (1)

Publication Number Publication Date
MX2010002448A true MX2010002448A (es) 2010-10-04

Family

ID=39862881

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002448A MX2010002448A (es) 2007-08-27 2008-08-27 Formulacion liquida del g-csf conjugado.

Country Status (24)

Country Link
US (1) US8546328B2 (es)
EP (2) EP2197919B1 (es)
JP (2) JP5570988B2 (es)
KR (1) KR20100052501A (es)
CN (2) CN104689333B (es)
AU (1) AU2008292186B9 (es)
BR (1) BRPI0815975B8 (es)
CA (1) CA2696594C (es)
CY (1) CY1115908T1 (es)
DE (1) DE202008017456U1 (es)
DK (1) DK2197919T3 (es)
EA (1) EA020069B1 (es)
ES (1) ES2476915T3 (es)
HR (1) HRP20140590T1 (es)
IL (1) IL204190A (es)
MX (1) MX2010002448A (es)
NZ (1) NZ583276A (es)
PL (1) PL2197919T3 (es)
PT (1) PT2197919E (es)
RS (1) RS53404B (es)
SI (1) SI2197919T1 (es)
UA (1) UA98001C2 (es)
WO (1) WO2009027437A1 (es)
ZA (1) ZA201000798B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE034398T2 (en) * 2010-01-19 2018-02-28 Hanmi Science Co Ltd Liquid preparations for sustained G-CSF conjugate
CA2789615A1 (en) 2010-03-17 2011-09-22 Biogenerix Gmbh Method for obtaining biologically active recombinant human g-csf
EP2384759A1 (en) 2010-05-06 2011-11-09 Suomen Punainen Risti Veripalvelu Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells
WO2017181920A1 (zh) * 2016-04-18 2017-10-26 江苏恒瑞医药股份有限公司 一种重组人粒细胞集落刺激因子的制备方法
IT201700108526A1 (it) * 2017-09-28 2019-03-28 Alfasigma Spa Composizioni orali per il trattamento del refluso gastroesofageo.
WO2019212429A2 (en) * 2018-05-04 2019-11-07 İlkogen İlaç Sanayi̇ Ve Ti̇caret A.Ş. Stable hybrid fc fusion g-csf formulation
CN114224853B (zh) * 2022-01-04 2022-09-23 山东新时代药业有限公司 聚乙二醇化重组人粒细胞刺激因子注射用冻干制剂
WO2024037633A2 (en) * 2022-08-19 2024-02-22 Evive Biotechnology (Shanghai) Ltd Formulations comprising g-csf and uses thereof

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Also Published As

Publication number Publication date
ZA201000798B (en) 2010-10-27
BRPI0815975A2 (pt) 2015-02-18
PL2197919T3 (pl) 2014-09-30
US8546328B2 (en) 2013-10-01
JP5836351B2 (ja) 2015-12-24
EP2578235A2 (en) 2013-04-10
HRP20140590T1 (hr) 2014-08-15
CN104689333B (zh) 2018-05-29
WO2009027437A1 (en) 2009-03-05
JP2010536929A (ja) 2010-12-02
JP5570988B2 (ja) 2014-08-13
AU2008292186A1 (en) 2009-03-05
EP2197919B1 (en) 2014-04-09
CA2696594C (en) 2019-03-19
EP2578235A3 (en) 2013-08-28
EA201070315A1 (ru) 2010-08-30
SI2197919T1 (sl) 2014-09-30
KR20100052501A (ko) 2010-05-19
US20110053844A1 (en) 2011-03-03
BRPI0815975B1 (pt) 2019-04-02
AU2008292186B9 (en) 2014-07-03
CY1115908T1 (el) 2017-01-25
BRPI0815975B8 (pt) 2021-05-25
CA2696594A1 (en) 2009-03-05
IL204190A (en) 2015-01-29
NZ583276A (en) 2012-06-29
CN104689333A (zh) 2015-06-10
UA98001C2 (uk) 2012-04-10
ES2476915T3 (es) 2014-07-15
RS53404B (en) 2014-10-31
EP2197919A1 (en) 2010-06-23
DK2197919T3 (da) 2014-07-07
JP2014101362A (ja) 2014-06-05
DE202008017456U1 (de) 2009-08-27
PT2197919E (pt) 2014-07-17
CN101827864A (zh) 2010-09-08
AU2008292186B2 (en) 2014-02-27
EA020069B1 (ru) 2014-08-29

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