JO3048B1 - مشتقات متاستين واستخدامها - Google Patents

مشتقات متاستين واستخدامها

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Publication number
JO3048B1
JO3048B1 JOP/2007/0448A JOP20070448A JO3048B1 JO 3048 B1 JO3048 B1 JO 3048B1 JO P20070448 A JOP20070448 A JO P20070448A JO 3048 B1 JO3048 B1 JO 3048B1
Authority
JO
Jordan
Prior art keywords
suppressing activity
activity
hormone secretion
metastin
metastin derivatives
Prior art date
Application number
JOP/2007/0448A
Other languages
English (en)
Inventor
Asami Taiji
Nishizawa Naoki
Original Assignee
Takeda Pharmaceuticals Co
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Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Application granted granted Critical
Publication of JO3048B1 publication Critical patent/JO3048B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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Abstract

يتعلق الاختراع الحالي بمشتقات متاستين (metastin) ثابتة لها انشطة حيوية ممتازة (نشاط لكبح السرطان, نشاط كبح نمو السرطان، نشاط يحث افراز هرمون انتحاء للغدد التناسلية، نشاط يحث افراز الهرمون الجنسي، الخ). بتعديل الاحماض الامينية(amino acids) التي تشكل المتاستين (metastin) مع احماض امينية (amino acids) خاصة، فانه يظهر بصورة غير متوقعة ثباتا وقابلية ذوبان محسنة في الدم، انخفاض الميل الى تكوين هلام، تحسنا في الحركة الدوائية، ويظهر اضافيا نشاطا ممتازا كابحا لانتشار السرطان او كابحا لنمو السرطان. ان مشتقات المتاستين (metastin) بصورة غير متوقعة لها تأثير كابح لافراز هرمون انتحاء للغدد التناسلية، تأثير كابح لافراز الهرمون الجنسي، الخ.
JOP/2007/0448A 2006-10-25 2007-10-23 مشتقات متاستين واستخدامها JO3048B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006290536 2006-10-25
JP2007021387 2007-01-31
JP2007221911 2007-08-28

Publications (1)

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JO3048B1 true JO3048B1 (ar) 2016-09-05

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JOP/2007/0448A JO3048B1 (ar) 2006-10-25 2007-10-23 مشتقات متاستين واستخدامها

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US (2) US7786083B2 (ar)
EP (1) EP2081955B1 (ar)
JP (2) JP2010507565A (ar)
KR (1) KR101424306B1 (ar)
AR (1) AR063367A1 (ar)
AU (1) AU2007309969B2 (ar)
BR (1) BRPI0717441B8 (ar)
CA (1) CA2667537C (ar)
CL (1) CL2007003053A1 (ar)
CR (1) CR10799A (ar)
CY (1) CY1116627T1 (ar)
DK (1) DK2081955T3 (ar)
EC (1) ECSP099279A (ar)
ES (1) ES2539430T3 (ar)
GE (1) GEP20125568B (ar)
HK (1) HK1130500A1 (ar)
HR (1) HRP20150819T1 (ar)
HU (1) HUE025291T2 (ar)
IL (1) IL198046A (ar)
JO (1) JO3048B1 (ar)
MA (1) MA30887B1 (ar)
ME (1) ME00786B (ar)
MX (1) MX2009004148A (ar)
MY (1) MY145975A (ar)
NO (1) NO341584B1 (ar)
NZ (1) NZ576375A (ar)
PE (1) PE20081469A1 (ar)
PL (1) PL2081955T3 (ar)
PT (1) PT2081955E (ar)
RS (1) RS54083B1 (ar)
SI (1) SI2081955T1 (ar)
TN (1) TN2009000140A1 (ar)
TW (1) TWI404726B (ar)
WO (1) WO2008050897A1 (ar)

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TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
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JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
US8110639B2 (en) * 2006-11-17 2012-02-07 Solvay Advanced Polymers, L.L.C. Transparent and flame retardant polysulfone compositions
WO2009131191A1 (ja) * 2008-04-24 2009-10-29 武田薬品工業株式会社 メタスチン誘導体およびその用途
US8592379B2 (en) * 2008-04-30 2013-11-26 Kyoto University Metastin derivative and use thereof
EP2314609B1 (en) * 2008-07-30 2016-11-30 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
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TWI795462B (zh) * 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑

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PE20081469A1 (es) 2008-12-25
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