CR10799A - Derivados de metastina y sus usos - Google Patents

Derivados de metastina y sus usos

Info

Publication number
CR10799A
CR10799A CR10799A CR10799A CR10799A CR 10799 A CR10799 A CR 10799A CR 10799 A CR10799 A CR 10799A CR 10799 A CR10799 A CR 10799A CR 10799 A CR10799 A CR 10799A
Authority
CR
Costa Rica
Prior art keywords
metastinine
derivatives
metastinine derivatives
Prior art date
Application number
CR10799A
Other languages
English (en)
Inventor
Taiji Asami
Naoki Nishizawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of CR10799A publication Critical patent/CR10799A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
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Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
CR10799A 2006-10-25 2009-05-15 Derivados de metastina y sus usos CR10799A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006290536 2006-10-25
JP2007021387 2007-01-31
JP2007221911 2007-08-28

Publications (1)

Publication Number Publication Date
CR10799A true CR10799A (es) 2009-06-09

Family

ID=38925530

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10799A CR10799A (es) 2006-10-25 2009-05-15 Derivados de metastina y sus usos

Country Status (34)

Country Link
US (2) US8765909B2 (es)
EP (1) EP2081955B1 (es)
JP (2) JP2010507565A (es)
KR (1) KR101424306B1 (es)
AR (1) AR063367A1 (es)
AU (1) AU2007309969B2 (es)
BR (1) BRPI0717441B8 (es)
CA (1) CA2667537C (es)
CL (1) CL2007003053A1 (es)
CR (1) CR10799A (es)
CY (1) CY1116627T1 (es)
DK (1) DK2081955T3 (es)
EC (1) ECSP099279A (es)
ES (1) ES2539430T3 (es)
GE (1) GEP20125568B (es)
HK (1) HK1130500A1 (es)
HR (1) HRP20150819T1 (es)
HU (1) HUE025291T2 (es)
IL (1) IL198046A (es)
JO (1) JO3048B1 (es)
MA (1) MA30887B1 (es)
ME (1) ME00786B (es)
MX (1) MX2009004148A (es)
MY (1) MY145975A (es)
NO (1) NO341584B1 (es)
NZ (1) NZ576375A (es)
PE (1) PE20081469A1 (es)
PL (1) PL2081955T3 (es)
PT (1) PT2081955E (es)
RS (1) RS54083B1 (es)
SI (1) SI2081955T1 (es)
TN (1) TN2009000140A1 (es)
TW (1) TWI404726B (es)
WO (1) WO2008050897A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1577323B1 (en) * 2002-12-26 2013-07-10 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
CA2571420A1 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
AR058584A1 (es) 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8183212B2 (en) * 2006-04-26 2012-05-22 Kyoto University Compound having GPR54 agonistic activity
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
US8110639B2 (en) * 2006-11-17 2012-02-07 Solvay Advanced Polymers, L.L.C. Transparent and flame retardant polysulfone compositions
JPWO2009131191A1 (ja) * 2008-04-24 2011-08-25 武田薬品工業株式会社 メタスチン誘導体およびその用途
US8592379B2 (en) * 2008-04-30 2013-11-26 Kyoto University Metastin derivative and use thereof
LT2314609T (lt) * 2008-07-30 2017-04-10 Takeda Pharmaceutical Company Limited Metastino darinys ir jo panaudojimas
US8716228B2 (en) 2009-05-27 2014-05-06 Yeda Research And Development Co. Ltd. GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities
UY33465A (es) * 2010-06-25 2012-01-31 Takeda Pharmaceutical Formulacion de liberacion sostenida
US9127038B2 (en) 2011-08-04 2015-09-08 Merck Sharp & Dohme Corp. Kisspeptide-pentasaccharide conjugates
AU2014280593B2 (en) * 2013-06-12 2018-11-08 Merck Patent Gmbh Hydroxy-ethylene derivatives for the treatment of arthrosis
WO2015112703A1 (en) * 2014-01-22 2015-07-30 The Johns Hopkins University Compositions and methods for treating diabetes
JP6253146B2 (ja) * 2014-02-04 2017-12-27 国立大学法人山口大学 新規なペプチド誘導体及びこれを含有する医薬
CN107428803A (zh) * 2015-02-08 2017-12-01 耶路撒冷希伯来大学伊萨姆研究发展有限公司 用于治疗恶性增殖性疾病的肽
EP3650464A4 (en) * 2017-07-05 2021-01-13 XDCExplorer (Shanghai) Co., Ltd. PEPTIDIC COMPOUND AND ITS APPLICATION, AND COMPOSITION CONTAINING A PEPTIDIC COMPOUND
TWI795462B (zh) * 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74827A (en) 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
MX9100717A (es) 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JPH09169735A (ja) 1995-10-19 1997-06-30 Takeda Chem Ind Ltd キノリン誘導体、その製造法および用途
DE69623655T2 (de) 1995-10-19 2003-04-24 Takeda Chemical Industries, Ltd. Chinolinderivate als gnrh antagonisten
JP2000510453A (ja) 1996-04-19 2000-08-15 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン遊離特性を有する化合物
WO1998039448A2 (en) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
JP4486187B2 (ja) 1998-10-27 2010-06-23 武田薬品工業株式会社 新規g蛋白質共役型レセプター蛋白質、そのdnaおよびそのリガンド
US6528054B1 (en) 1998-12-28 2003-03-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
BR0012006A (pt) 1999-06-28 2002-03-12 Basf Ag Método para evitar inflamações, doenças autoimunes e crescimento de tumor, e, uso de substâncias que suprimem a ativação mediada por ltbr
US6638906B1 (en) 1999-12-13 2003-10-28 Nobex Corporation Amphiphilic polymers and polypeptide conjugates comprising same
CA2394404A1 (en) 1999-12-17 2001-06-21 Takeda Chemical Industries, Ltd. Process for producing kiss-1 peptide
CA2404233A1 (en) 2000-03-29 2001-10-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US20050240008A1 (en) 2000-03-30 2005-10-27 Tetsuya Ohtaki Novel protein, dna thereof and process for producing the same
US7834141B1 (en) 2000-03-31 2010-11-16 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
RU2311920C2 (ru) 2000-09-20 2007-12-10 Корикса Корпорейшн Композиции и способы для лечения и диагностики рака легких
JP2003026601A (ja) 2000-11-29 2003-01-29 Takeda Chem Ind Ltd 医薬組成物およびその製造法
JP2002320496A (ja) 2001-02-26 2002-11-05 Takeda Chem Ind Ltd 新規マウス型KiSS−1レセプタータンパク質およびそのDNA
WO2002085399A1 (en) 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Peptide-containing preparations
CN1509336A (zh) * 2001-05-17 2004-06-30 株式会社岛津制作所 肽的制备方法
US7112662B2 (en) 2001-09-19 2006-09-26 Takeda Pharmaceutical Company Limited Anti-metasin antibodies and their methods of use
US20050176091A1 (en) 2002-01-11 2005-08-11 Takao Yamada Process for producing kiss-1 peptide
JP2003300906A (ja) 2002-04-12 2003-10-21 Daiichi Fine Chemical Co Ltd がん転移抑制因子の安定化
US20060035875A1 (en) * 2002-10-09 2006-02-16 Yukimasa Shiotsu Remedy for hormone-dependent cancer
DE60327344D1 (de) 2002-10-25 2009-06-04 Takeda Pharmaceutical Gpr54 'knock-out' säugetiere und screening-verfahren, die sie verwenden
EP1577323B1 (en) 2002-12-26 2013-07-10 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
JP4804714B2 (ja) * 2002-12-26 2011-11-02 武田薬品工業株式会社 メタスチン誘導体およびその用途
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
KR100595364B1 (ko) 2003-02-20 2006-07-03 재단법인 목암생명공학연구소 Lk8 단백질을 유효성분으로 포함하는 항암제
CA2518541C (en) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Gonadal function improving agents
EP1464652A1 (en) 2003-04-02 2004-10-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases
US20050002935A1 (en) 2003-04-17 2005-01-06 Vincent Ling Use of B7-H3 as an immunoregulatory agent
US20050026224A1 (en) 2003-04-28 2005-02-03 Follettie Maximillian T. Methods and compositions for modulating G-protein coupled receptor 54
WO2004101747A2 (en) 2003-05-07 2004-11-25 The General Hospital Corporation Identification and use of gpr54 and its ligands for reproductive disorders and contraception
DK1633702T3 (da) 2003-05-30 2008-11-10 Prozymex As Proteaseinhibitorer
US7666989B2 (en) 2003-11-03 2010-02-23 Beijing Sunbio Biotech Co., Ltd. Recombinant protein having an anti-cancer effect, its encoding gene and uses thereof
WO2005095973A2 (en) 2004-03-25 2005-10-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54)
WO2005117939A2 (en) 2004-04-23 2005-12-15 Applied Research Systems Ars Holding N.V. Use of gpcr54 ligands for the treatment of infertility
CA2571420A1 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
WO2007084211A2 (en) 2005-11-11 2007-07-26 The General Hospital Corporation Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception
AR058584A1 (es) * 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20070244048A1 (en) 2006-03-20 2007-10-18 Marsh Donald J Neuromedin U receptor agonists and uses thereof
AU2007231553B2 (en) * 2006-03-28 2012-10-25 Molecular Discovery Systems Agent for the treatment of hormone-dependent disorders and uses thereof
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
JPWO2009044918A1 (ja) 2007-10-05 2011-02-17 武田薬品工業株式会社 ニューロメジンu誘導体
JPWO2009131191A1 (ja) 2008-04-24 2011-08-25 武田薬品工業株式会社 メタスチン誘導体およびその用途
WO2010033224A1 (en) 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of kiss1 peptides

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