MA30887B1 - Derives de metastine et leur utilisation - Google Patents

Derives de metastine et leur utilisation

Info

Publication number
MA30887B1
MA30887B1 MA31868A MA31868A MA30887B1 MA 30887 B1 MA30887 B1 MA 30887B1 MA 31868 A MA31868 A MA 31868A MA 31868 A MA31868 A MA 31868A MA 30887 B1 MA30887 B1 MA 30887B1
Authority
MA
Morocco
Prior art keywords
activity
suppression activity
secretion
gonatotropic
enhanced
Prior art date
Application number
MA31868A
Other languages
English (en)
Inventor
Taiji Asami
Naoki Nishizawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA30887B1 publication Critical patent/MA30887B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
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Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)

Abstract

LA PRÉSENTE INVENTION PORTE SUR DES DÉRIVÉS DE MÉTASTINE STABLES, AYANT D'EXCELLENTES ACTIVITÉS BIOLOGIQUES (UNE ACTIVITÉ DE SUPPRESSION DES MÉTASTASES DU CANCER, UNE ACTIVITÉ DE SUPPRESSION DE LA CROISSANCE DU CANCER, UNE ACTIVITÉ STIMULANT LA SÉCRÉTION DE L'HORMONE GONATOTROPIQUE, UNE ACTIVITÉ DE STIMULATION DE LA SÉCRÉTION DE L'HORMONE SEXUELLE, ETC.). PAR LE REMPLACEMENT DES ACIDES AMINÉS CONSTITUTIFS DE LA MÉTASTINE PAR DES ACIDES AMINÉS SPÉCIFIQUES, LES DÉRIVÉS DE MÉTASTINE DE LA PRÉSENTE INVENTION PERMETTENT DE PARVENIR À UNE STABILITÉ DANS LE SANG, UNE SOLUBILITÉ, ETC. DAVANTAGE AMÉLIORÉES, À UNE TENDANCE RÉDUITE À LA GÉLIFICATION, À UNE PHARMACO-CINÉTIQUE AMÉLIORÉE. EGALEMENT, ILS PRÉSENTENT UNE EXCELLENTE ACTIVITÉ DE SUPPRESSION DES MÉTASTASES DU CANCER OU UNE ACTIVITÉ DE SUPPRESSION DE LA CROISSANCE DU CANCER. LES DÉRIVÉS DE MÉTASTINE DE LA PRÉSENTE INVENTION ONT ÉGALEMENT UNE ACTIVITÉ DE SUPPRESSION DE LA SÉCRÉTION DE L'HORMONE GONATOTROPIQUE, UNE ACTIVITÉ DE SUPPRESSION DE LA SÉCRÉTION DE L'HORMONE SEXUELLE, ETC.
MA31868A 2006-10-25 2009-05-13 Derives de metastine et leur utilisation MA30887B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006290536 2006-10-25
JP2007021387 2007-01-31
JP2007221911 2007-08-28

Publications (1)

Publication Number Publication Date
MA30887B1 true MA30887B1 (fr) 2009-11-02

Family

ID=38925530

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31868A MA30887B1 (fr) 2006-10-25 2009-05-13 Derives de metastine et leur utilisation

Country Status (34)

Country Link
US (2) US7786083B2 (fr)
EP (1) EP2081955B1 (fr)
JP (2) JP2010507565A (fr)
KR (1) KR101424306B1 (fr)
AR (1) AR063367A1 (fr)
AU (1) AU2007309969B2 (fr)
BR (1) BRPI0717441B8 (fr)
CA (1) CA2667537C (fr)
CL (1) CL2007003053A1 (fr)
CR (1) CR10799A (fr)
CY (1) CY1116627T1 (fr)
DK (1) DK2081955T3 (fr)
EC (1) ECSP099279A (fr)
ES (1) ES2539430T3 (fr)
GE (1) GEP20125568B (fr)
HK (1) HK1130500A1 (fr)
HR (1) HRP20150819T1 (fr)
HU (1) HUE025291T2 (fr)
IL (1) IL198046A (fr)
JO (1) JO3048B1 (fr)
MA (1) MA30887B1 (fr)
ME (1) ME00786B (fr)
MX (1) MX2009004148A (fr)
MY (1) MY145975A (fr)
NO (1) NO341584B1 (fr)
NZ (1) NZ576375A (fr)
PE (1) PE20081469A1 (fr)
PL (1) PL2081955T3 (fr)
PT (1) PT2081955E (fr)
RS (1) RS54083B1 (fr)
SI (1) SI2081955T1 (fr)
TN (1) TN2009000140A1 (fr)
TW (1) TWI404726B (fr)
WO (1) WO2008050897A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050090420A (ko) 2002-12-26 2005-09-13 다케다 야쿠힌 고교 가부시키가이샤 메타스틴 유도체 및 이의 용도
SG153865A1 (en) 2004-06-25 2009-07-29 Takeda Pharmaceutical Metastin derivatives and use thereof
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8183212B2 (en) * 2006-04-26 2012-05-22 Kyoto University Compound having GPR54 agonistic activity
TWI404726B (zh) 2006-10-25 2013-08-11 Takeda Pharmaceutical 腫瘤轉移抑制素衍生物及其用途
US8110639B2 (en) * 2006-11-17 2012-02-07 Solvay Advanced Polymers, L.L.C. Transparent and flame retardant polysulfone compositions
JPWO2009131191A1 (ja) * 2008-04-24 2011-08-25 武田薬品工業株式会社 メタスチン誘導体およびその用途
WO2009139298A1 (fr) * 2008-04-30 2009-11-19 国立大学法人京都大学 Dérivé de metastine et son utilisation
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