MX2009004148A - Derivados de metastina y uso de los mismos. - Google Patents
Derivados de metastina y uso de los mismos.Info
- Publication number
- MX2009004148A MX2009004148A MX2009004148A MX2009004148A MX2009004148A MX 2009004148 A MX2009004148 A MX 2009004148A MX 2009004148 A MX2009004148 A MX 2009004148A MX 2009004148 A MX2009004148 A MX 2009004148A MX 2009004148 A MX2009004148 A MX 2009004148A
- Authority
- MX
- Mexico
- Prior art keywords
- suppressing activity
- activity
- hormone secretion
- metastin
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
Abstract
La presente invención proporciona derivados de metastina estables que tienen actividades biológicas excelentes (una actividad de supresión de metástasis de cáncer, actividad de supresión de crecimiento de cáncer, actividad de estimulación de secreción de hormona gonadotrópica, actividad de estimulación de secreción de hormona sexual, etc.). Al substituir los aminoácidos constituyentes de metastina con aminoácidos específicos, los derivados de metastina de la presente invención logran una estabilidad en sangre, solubilidad, etc., muy mejorada, una tendencia a la gelatinización reducida, farmacocinéticas mejoradas, así como también exhiben una excelente actividad de supresión de metástasis de cáncer, o actividad de supresión de crecimiento de cáncer. Los derivados de metastina de la presente invención también tienen una actividad de supresión de secreción de hormona gonadotrópica, actividad de supresión de secreción de hormona sexual, etc.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006290536 | 2006-10-25 | ||
| JP2007021387 | 2007-01-31 | ||
| JP2007221911 | 2007-08-28 | ||
| PCT/JP2007/071169 WO2008050897A1 (en) | 2006-10-25 | 2007-10-24 | Metastin derivatives and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009004148A true MX2009004148A (es) | 2009-05-01 |
Family
ID=38925530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009004148A MX2009004148A (es) | 2006-10-25 | 2007-10-24 | Derivados de metastina y uso de los mismos. |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US7786083B2 (es) |
| EP (1) | EP2081955B1 (es) |
| JP (2) | JP2010507565A (es) |
| KR (1) | KR101424306B1 (es) |
| AR (1) | AR063367A1 (es) |
| AU (1) | AU2007309969B2 (es) |
| BR (1) | BRPI0717441B8 (es) |
| CA (1) | CA2667537C (es) |
| CL (1) | CL2007003053A1 (es) |
| CR (1) | CR10799A (es) |
| CY (1) | CY1116627T1 (es) |
| DK (1) | DK2081955T3 (es) |
| EC (1) | ECSP099279A (es) |
| ES (1) | ES2539430T3 (es) |
| GE (1) | GEP20125568B (es) |
| HK (1) | HK1130500A1 (es) |
| HR (1) | HRP20150819T1 (es) |
| HU (1) | HUE025291T2 (es) |
| IL (1) | IL198046A (es) |
| JO (1) | JO3048B1 (es) |
| MA (1) | MA30887B1 (es) |
| ME (1) | ME00786B (es) |
| MX (1) | MX2009004148A (es) |
| MY (1) | MY145975A (es) |
| NO (1) | NO341584B1 (es) |
| NZ (1) | NZ576375A (es) |
| PE (1) | PE20081469A1 (es) |
| PL (1) | PL2081955T3 (es) |
| PT (1) | PT2081955E (es) |
| RS (1) | RS54083B1 (es) |
| SI (1) | SI2081955T1 (es) |
| TN (1) | TN2009000140A1 (es) |
| TW (1) | TWI404726B (es) |
| WO (1) | WO2008050897A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050090420A (ko) | 2002-12-26 | 2005-09-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 메타스틴 유도체 및 이의 용도 |
| SG153865A1 (en) | 2004-06-25 | 2009-07-29 | Takeda Pharmaceutical | Metastin derivatives and use thereof |
| US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8183212B2 (en) * | 2006-04-26 | 2012-05-22 | Kyoto University | Compound having GPR54 agonistic activity |
| TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
| US8110639B2 (en) * | 2006-11-17 | 2012-02-07 | Solvay Advanced Polymers, L.L.C. | Transparent and flame retardant polysulfone compositions |
| JPWO2009131191A1 (ja) * | 2008-04-24 | 2011-08-25 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| WO2009139298A1 (ja) * | 2008-04-30 | 2009-11-19 | 国立大学法人京都大学 | メタスチン誘導体およびその用途 |
| WO2010013762A1 (ja) * | 2008-07-30 | 2010-02-04 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| WO2010137022A1 (en) * | 2009-05-27 | 2010-12-02 | Yeda Research And Development Co. Ltd | Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| EP2585091B1 (en) * | 2010-06-25 | 2014-09-10 | Takeda Pharmaceutical Company Limited | Sustained-release formulation comprising a metastin derivative |
| WO2013017631A1 (en) | 2011-08-04 | 2013-02-07 | Msd Oss B.V. | Kisspeptide-pentasaccharide conjugates |
| CA2915055C (en) * | 2013-06-12 | 2021-07-20 | Merck Patent Gmbh | Hydroxyethylene derivatives for the treatment of arthrosis |
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