UA94774C2 - Metastin derivatives and use thereof - Google Patents

Metastin derivatives and use thereof

Info

Publication number
UA94774C2
UA94774C2 UAA200905103A UAA200905103A UA94774C2 UA 94774 C2 UA94774 C2 UA 94774C2 UA A200905103 A UAA200905103 A UA A200905103A UA A200905103 A UAA200905103 A UA A200905103A UA 94774 C2 UA94774 C2 UA 94774C2
Authority
UA
Ukraine
Prior art keywords
suppressing activity
activity
hormone secretion
derivatives
metastin
Prior art date
Application number
UAA200905103A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Тайджи Асами
Наоки Нишизава
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of UA94774C2 publication Critical patent/UA94774C2/en

Links

Abstract

The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.). By substituting the constituent amino acids of metastin with specific amino acids, the metastin derivatives of the present invention achieve more improved blood stability, solubility, etc., reduced gelation tendency, improved pharmacokinetics, as well as exhibit an excellent cancer metastasis suppressing activity or a cancer growth suppressing activity. The melastin derivatives of the present invention also have a gonadotropic hormone secretion suppressing activity, sex hormone secretion suppressing activity, etc.
UAA200905103A 2006-10-25 2007-10-24 Metastin derivatives and use thereof UA94774C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006290536 2006-10-25

Publications (1)

Publication Number Publication Date
UA94774C2 true UA94774C2 (en) 2011-06-10

Family

ID=41095736

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200905103A UA94774C2 (en) 2006-10-25 2007-10-24 Metastin derivatives and use thereof

Country Status (4)

Country Link
CN (1) CN101528772B (en)
AR (1) AR108283A2 (en)
UA (1) UA94774C2 (en)
ZA (1) ZA200902452B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9777148B2 (en) 2010-05-11 2017-10-03 Bioretec Oy Biocompatible material and device
WO2011162413A1 (en) * 2010-06-25 2011-12-29 Takeda Pharmaceutical Company Limited Sustained-release formulation
CA2915055C (en) * 2013-06-12 2021-07-20 Merck Patent Gmbh Hydroxyethylene derivatives for the treatment of arthrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004063221A1 (en) * 2002-12-26 2004-07-29 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
SG153865A1 (en) * 2004-06-25 2009-07-29 Takeda Pharmaceutical Metastin derivatives and use thereof

Also Published As

Publication number Publication date
ZA200902452B (en) 2010-07-28
CN101528772A (en) 2009-09-09
AR108283A2 (en) 2018-08-08
CN101528772B (en) 2013-03-13

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