UA94774C2 - Metastin derivatives and use thereof - Google Patents
Metastin derivatives and use thereofInfo
- Publication number
- UA94774C2 UA94774C2 UAA200905103A UAA200905103A UA94774C2 UA 94774 C2 UA94774 C2 UA 94774C2 UA A200905103 A UAA200905103 A UA A200905103A UA A200905103 A UAA200905103 A UA A200905103A UA 94774 C2 UA94774 C2 UA 94774C2
- Authority
- UA
- Ukraine
- Prior art keywords
- suppressing activity
- activity
- hormone secretion
- derivatives
- metastin
- Prior art date
Links
Abstract
The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.). By substituting the constituent amino acids of metastin with specific amino acids, the metastin derivatives of the present invention achieve more improved blood stability, solubility, etc., reduced gelation tendency, improved pharmacokinetics, as well as exhibit an excellent cancer metastasis suppressing activity or a cancer growth suppressing activity. The melastin derivatives of the present invention also have a gonadotropic hormone secretion suppressing activity, sex hormone secretion suppressing activity, etc.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006290536 | 2006-10-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA94774C2 true UA94774C2 (en) | 2011-06-10 |
Family
ID=41095736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200905103A UA94774C2 (en) | 2006-10-25 | 2007-10-24 | Metastin derivatives and use thereof |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN101528772B (en) |
AR (1) | AR108283A2 (en) |
UA (1) | UA94774C2 (en) |
ZA (1) | ZA200902452B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9777148B2 (en) | 2010-05-11 | 2017-10-03 | Bioretec Oy | Biocompatible material and device |
WO2011162413A1 (en) * | 2010-06-25 | 2011-12-29 | Takeda Pharmaceutical Company Limited | Sustained-release formulation |
CA2915055C (en) * | 2013-06-12 | 2021-07-20 | Merck Patent Gmbh | Hydroxyethylene derivatives for the treatment of arthrosis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004063221A1 (en) * | 2002-12-26 | 2004-07-29 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
US6800611B2 (en) * | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
SG153865A1 (en) * | 2004-06-25 | 2009-07-29 | Takeda Pharmaceutical | Metastin derivatives and use thereof |
-
2007
- 2007-10-24 ZA ZA200902452A patent/ZA200902452B/en unknown
- 2007-10-24 UA UAA200905103A patent/UA94774C2/en unknown
- 2007-10-24 CN CN200780039666.6A patent/CN101528772B/en active Active
-
2017
- 2017-04-19 AR ARP170101004A patent/AR108283A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200902452B (en) | 2010-07-28 |
CN101528772A (en) | 2009-09-09 |
AR108283A2 (en) | 2018-08-08 |
CN101528772B (en) | 2013-03-13 |
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