TW200734352A - Growth hormone variations - Google Patents

Growth hormone variations

Info

Publication number
TW200734352A
TW200734352A TW095148927A TW95148927A TW200734352A TW 200734352 A TW200734352 A TW 200734352A TW 095148927 A TW095148927 A TW 095148927A TW 95148927 A TW95148927 A TW 95148927A TW 200734352 A TW200734352 A TW 200734352A
Authority
TW
Taiwan
Prior art keywords
growth hormone
hormone variations
variations
variants
hypertension
Prior art date
Application number
TW095148927A
Other languages
Chinese (zh)
Inventor
David Neil Cooper
Martin Horan
Mark Lewis
David Stuart Millar
Original Assignee
Univ Cardiff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff filed Critical Univ Cardiff
Publication of TW200734352A publication Critical patent/TW200734352A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to novel variants in the growth hormone gene and the corresponding variants in the protein structure and the use of same in the diagnosis of growth hormone dysfunction, hypertension or stroke.
TW095148927A 2006-01-05 2006-12-26 Growth hormone variations TW200734352A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0600114.3A GB0600114D0 (en) 2006-01-05 2006-01-05 Growth hormone variations

Publications (1)

Publication Number Publication Date
TW200734352A true TW200734352A (en) 2007-09-16

Family

ID=35911393

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095148927A TW200734352A (en) 2006-01-05 2006-12-26 Growth hormone variations

Country Status (5)

Country Link
AR (1) AR059131A1 (en)
GB (2) GB0600114D0 (en)
NL (1) NL1033169A1 (en)
TW (1) TW200734352A (en)
WO (1) WO2007077423A2 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0110756A (en) * 2000-05-12 2003-07-08 Univ Wales Medicine Detection method for detecting a variation in gh1 effective to act as an indicator of gh dysfunction in an individual, gh1 variant, protein or amino acid sequence, human gh variant, screening method for screening an individual suspected of having gh1 dysfunction. gh, kit, isolated, purified or recombinant nucleic acid sequence, vector, host cell, process for preparing a gh variant, amino acid sequence, composition, and use of gh1 variant or gh variant
JP2005508650A (en) * 2001-11-09 2005-04-07 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー Single nucleotide polymorphism in GH-1
BR0213957A (en) * 2001-11-12 2004-09-08 Univ Wales Medicine Isolated recombinant polynucleotide, nucleic acid sequence, human gh variant, screening method for screening a patient suspected of having dysfunctional gh, suitable kit for use in performing a screening method, use of a gh1 variant, antibody specific for a variant, composition, vector, host cell, process for preparing a variant of gh, amino acid sequence or protein encoded or expressed by a sequence, vector, or cell
EP1663277A2 (en) * 2003-08-20 2006-06-07 Neuren Pharmaceuticals Limited Somatogenic therapy using a 20kda placental variant of growth hormone
CN1661053A (en) * 2004-02-25 2005-08-31 复旦大学 Relativity between gene of growth hormone 1 and essential hypertension

Also Published As

Publication number Publication date
GB0600114D0 (en) 2006-02-15
AR059131A1 (en) 2008-03-12
NL1033169A1 (en) 2007-07-09
GB0625888D0 (en) 2007-02-07
GB2433991A (en) 2007-07-11
WO2007077423A2 (en) 2007-07-12
WO2007077423A3 (en) 2007-10-25

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