MX337358B - Conjugados de disorazoles y sus derivados con moleculas de union con celulas, nuevos derivados de disorazol, procesos de fabricacion y usos de los mismos. - Google Patents
Conjugados de disorazoles y sus derivados con moleculas de union con celulas, nuevos derivados de disorazol, procesos de fabricacion y usos de los mismos.Info
- Publication number
- MX337358B MX337358B MX2011010178A MX2011010178A MX337358B MX 337358 B MX337358 B MX 337358B MX 2011010178 A MX2011010178 A MX 2011010178A MX 2011010178 A MX2011010178 A MX 2011010178A MX 337358 B MX337358 B MX 337358B
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- conjugates
- disorazoles
- processes
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invención se refiere a conjugados de disorazoles y sus derivados con moléculas de unión con células, tales como péptidos, proteínas, hormonas, proteínas sanguíneas y anticuerpos. La presente invención también proporciona nuevos derivados de disorazol y procesos para fabricar estos conjugados y derivados de disorazol. Estos compuestos pueden ser usados como medicamentos para el tratamiento de condiciones fisiológicas y/o patofisiológicas en mamíferos, particularmente para el tratamiento de diversos tumores.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84235706P | 2006-09-06 | 2006-09-06 | |
EP06018750A EP1900742A1 (en) | 2006-09-07 | 2006-09-07 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
PCT/EP2007/059310 WO2008028934A1 (en) | 2006-09-06 | 2007-09-06 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX337358B true MX337358B (es) | 2016-02-29 |
Family
ID=37670733
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009002483A MX2009002483A (es) | 2006-09-06 | 2007-09-06 | Conjugados de disorazolas y sus derivados con moleculas de union con celulas, nuevos derivados de disorazola, procedimientos para fabricarlos y usos de los mismos. |
MX2011010178A MX337358B (es) | 2006-09-06 | 2007-09-06 | Conjugados de disorazoles y sus derivados con moleculas de union con celulas, nuevos derivados de disorazol, procesos de fabricacion y usos de los mismos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009002483A MX2009002483A (es) | 2006-09-06 | 2007-09-06 | Conjugados de disorazolas y sus derivados con moleculas de union con celulas, nuevos derivados de disorazola, procedimientos para fabricarlos y usos de los mismos. |
Country Status (16)
Country | Link |
---|---|
US (3) | US7741277B2 (es) |
EP (2) | EP1900742A1 (es) |
KR (1) | KR101532966B1 (es) |
AR (1) | AR062685A1 (es) |
AU (1) | AU2007293650B2 (es) |
CA (1) | CA2662308C (es) |
DK (1) | DK2066679T3 (es) |
ES (1) | ES2572183T3 (es) |
HU (1) | HUE028061T2 (es) |
MX (2) | MX2009002483A (es) |
NZ (1) | NZ575032A (es) |
PL (1) | PL2066679T3 (es) |
RS (1) | RS54857B1 (es) |
SI (1) | SI2066679T1 (es) |
TW (1) | TWI346116B (es) |
WO (1) | WO2008028934A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1900742A1 (en) | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
WO2010033224A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
EP2350118B1 (en) | 2008-09-19 | 2016-03-30 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
WO2010096175A1 (en) * | 2009-02-20 | 2010-08-26 | Ipsen Pharma S.A.S. | Cytotoxic conjugates having neuropeptide y receptor binding compound |
US20120004182A1 (en) * | 2010-07-02 | 2012-01-05 | Carsten Gruendker | Pharmaceutical compositions and methods for induction and enhancement of apoptosis in tumor cells |
CN114966050A (zh) * | 2012-03-18 | 2022-08-30 | 镜株式会社 | 疾病样品分析装置、分析系统及分析方法 |
KR101974583B1 (ko) | 2012-08-29 | 2019-05-02 | 삼성전자주식회사 | 링커 폴리펩티드 및 이를 이용한 표적 물질 분석 방법 |
EP3641891A4 (en) | 2017-06-22 | 2021-01-27 | William Marsh Rice University | SYNTHESIS OF DISORAZOLES AND THEIR ANALOGUES AS POWERFUL ANTI-CANCER AGENTS |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214969B1 (en) | 1988-10-21 | 2001-04-10 | The Administrators Of The Tulane Educational Fund | Luteinizing hormone releasing hormone analogs with cytotoxic moiety |
US5866679A (en) | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
AU715632B2 (en) | 1996-09-12 | 2000-02-03 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
DE19728737C1 (de) | 1997-07-04 | 1999-02-11 | Johannes Christian Groeninghen | Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten |
DE69820644D1 (de) | 1997-07-10 | 2004-01-29 | Merck & Co Inc | Konjugate welche bei der behandlung von prostatakrebs nützlich sind |
CN1678310A (zh) * | 2002-08-24 | 2005-10-05 | 赞塔里斯有限公司 | 用于治疗良性和恶性肿瘤疾病的含有disorazole及其衍生物的药物 |
AU2003298864A1 (en) | 2002-12-06 | 2004-06-30 | Kosan Biosciences, Inc. | Disorazole polyketide synthase encoding polynucleotides |
NZ550934A (en) * | 2004-05-19 | 2010-05-28 | Medarex Inc | Chemical linkers and conjugates thereof |
US20060199252A1 (en) | 2005-01-13 | 2006-09-07 | Herbert Irschik | Genes encoding the synthetic pathway for the production of disorazole |
EP1838848A1 (en) | 2005-01-13 | 2007-10-03 | Helmholtz-Zentrum für Infektionsforschung GmbH | Genes encoding the synthetic pathway for the production of disorazole |
WO2006135371A1 (en) * | 2005-06-09 | 2006-12-21 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
EP1743897A1 (en) * | 2005-07-15 | 2007-01-17 | Gesellschaft für Biotechnologische Forschung mbH | Biologically active compounds obtainable from Sorangium cellulosum |
EP1900742A1 (en) | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
-
2006
- 2006-09-07 EP EP06018750A patent/EP1900742A1/en not_active Withdrawn
-
2007
- 2007-09-06 MX MX2009002483A patent/MX2009002483A/es active IP Right Grant
- 2007-09-06 NZ NZ575032A patent/NZ575032A/en not_active IP Right Cessation
- 2007-09-06 CA CA2662308A patent/CA2662308C/en not_active Expired - Fee Related
- 2007-09-06 WO PCT/EP2007/059310 patent/WO2008028934A1/en active Application Filing
- 2007-09-06 ES ES07803270T patent/ES2572183T3/es active Active
- 2007-09-06 PL PL07803270.3T patent/PL2066679T3/pl unknown
- 2007-09-06 US US11/850,747 patent/US7741277B2/en not_active Expired - Fee Related
- 2007-09-06 RS RS20160412A patent/RS54857B1/sr unknown
- 2007-09-06 AU AU2007293650A patent/AU2007293650B2/en not_active Ceased
- 2007-09-06 DK DK07803270.3T patent/DK2066679T3/en active
- 2007-09-06 HU HUE07803270A patent/HUE028061T2/en unknown
- 2007-09-06 AR ARP070103942A patent/AR062685A1/es not_active Application Discontinuation
- 2007-09-06 EP EP07803270.3A patent/EP2066679B1/en active Active
- 2007-09-06 MX MX2011010178A patent/MX337358B/es unknown
- 2007-09-06 SI SI200731775A patent/SI2066679T1/sl unknown
- 2007-09-06 TW TW096133272A patent/TWI346116B/zh not_active IP Right Cessation
- 2007-09-06 KR KR1020097007093A patent/KR101532966B1/ko not_active IP Right Cessation
-
2010
- 2010-03-19 US US12/728,075 patent/US20100323963A1/en not_active Abandoned
- 2010-03-19 US US12/728,050 patent/US8470776B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR062685A1 (es) | 2008-11-26 |
KR101532966B1 (ko) | 2015-07-02 |
EP2066679A1 (en) | 2009-06-10 |
US20080090758A1 (en) | 2008-04-17 |
TW200823228A (en) | 2008-06-01 |
US8470776B2 (en) | 2013-06-25 |
WO2008028934A1 (en) | 2008-03-13 |
AU2007293650A1 (en) | 2008-03-13 |
ES2572183T3 (es) | 2016-05-30 |
US20100317580A1 (en) | 2010-12-16 |
KR20090064436A (ko) | 2009-06-18 |
MX2009002483A (es) | 2009-03-23 |
WO2008028934A8 (en) | 2008-05-02 |
US7741277B2 (en) | 2010-06-22 |
AU2007293650B2 (en) | 2012-06-14 |
NZ575032A (en) | 2011-02-25 |
RU2009112546A (ru) | 2010-10-20 |
EP2066679B1 (en) | 2016-03-09 |
CA2662308A1 (en) | 2008-03-13 |
DK2066679T3 (en) | 2016-06-27 |
US20100323963A1 (en) | 2010-12-23 |
TWI346116B (en) | 2011-08-01 |
HUE028061T2 (en) | 2016-11-28 |
SI2066679T1 (sl) | 2016-06-30 |
EP1900742A1 (en) | 2008-03-19 |
PL2066679T3 (pl) | 2016-09-30 |
RS54857B1 (sr) | 2016-10-31 |
CA2662308C (en) | 2014-10-28 |
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