MX337358B - Conjugados de disorazoles y sus derivados con moleculas de union con celulas, nuevos derivados de disorazol, procesos de fabricacion y usos de los mismos. - Google Patents

Conjugados de disorazoles y sus derivados con moleculas de union con celulas, nuevos derivados de disorazol, procesos de fabricacion y usos de los mismos.

Info

Publication number
MX337358B
MX337358B MX2011010178A MX2011010178A MX337358B MX 337358 B MX337358 B MX 337358B MX 2011010178 A MX2011010178 A MX 2011010178A MX 2011010178 A MX2011010178 A MX 2011010178A MX 337358 B MX337358 B MX 337358B
Authority
MX
Mexico
Prior art keywords
derivatives
conjugates
disorazoles
processes
cell
Prior art date
Application number
MX2011010178A
Other languages
English (en)
Inventor
Eckhard Günther
Klaus Paulini
Michael Teifel
Olaf Shaefer
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of MX337358B publication Critical patent/MX337358B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a conjugados de disorazoles y sus derivados con moléculas de unión con células, tales como péptidos, proteínas, hormonas, proteínas sanguíneas y anticuerpos. La presente invención también proporciona nuevos derivados de disorazol y procesos para fabricar estos conjugados y derivados de disorazol. Estos compuestos pueden ser usados como medicamentos para el tratamiento de condiciones fisiológicas y/o patofisiológicas en mamíferos, particularmente para el tratamiento de diversos tumores.
MX2011010178A 2006-09-06 2007-09-06 Conjugados de disorazoles y sus derivados con moleculas de union con celulas, nuevos derivados de disorazol, procesos de fabricacion y usos de los mismos. MX337358B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84235706P 2006-09-06 2006-09-06
EP06018750A EP1900742A1 (en) 2006-09-07 2006-09-07 Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
PCT/EP2007/059310 WO2008028934A1 (en) 2006-09-06 2007-09-06 Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof

Publications (1)

Publication Number Publication Date
MX337358B true MX337358B (es) 2016-02-29

Family

ID=37670733

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009002483A MX2009002483A (es) 2006-09-06 2007-09-06 Conjugados de disorazolas y sus derivados con moleculas de union con celulas, nuevos derivados de disorazola, procedimientos para fabricarlos y usos de los mismos.
MX2011010178A MX337358B (es) 2006-09-06 2007-09-06 Conjugados de disorazoles y sus derivados con moleculas de union con celulas, nuevos derivados de disorazol, procesos de fabricacion y usos de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2009002483A MX2009002483A (es) 2006-09-06 2007-09-06 Conjugados de disorazolas y sus derivados con moleculas de union con celulas, nuevos derivados de disorazola, procedimientos para fabricarlos y usos de los mismos.

Country Status (16)

Country Link
US (3) US7741277B2 (es)
EP (2) EP1900742A1 (es)
KR (1) KR101532966B1 (es)
AR (1) AR062685A1 (es)
AU (1) AU2007293650B2 (es)
CA (1) CA2662308C (es)
DK (1) DK2066679T3 (es)
ES (1) ES2572183T3 (es)
HU (1) HUE028061T2 (es)
MX (2) MX2009002483A (es)
NZ (1) NZ575032A (es)
PL (1) PL2066679T3 (es)
RS (1) RS54857B1 (es)
SI (1) SI2066679T1 (es)
TW (1) TWI346116B (es)
WO (1) WO2008028934A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1900742A1 (en) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
EP2340047A1 (en) * 2008-09-19 2011-07-06 Nektar Therapeutics Polymer conjugates of kiss1 peptides
AU2009292643B2 (en) 2008-09-19 2016-02-18 Nektar Therapeutics Polymer conjugates of therapeutic peptides
JP5584236B2 (ja) * 2009-02-20 2014-09-03 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ 神経ペプチドｙ受容体結合化合物を有する細胞毒性コンジュゲート
US20120004182A1 (en) * 2010-07-02 2012-01-05 Carsten Gruendker Pharmaceutical compositions and methods for induction and enhancement of apoptosis in tumor cells
EP3663758A1 (en) * 2012-03-18 2020-06-10 Shiseido Company, Ltd. Apparatus, system and method for analyzing disease sample
KR101974583B1 (ko) 2012-08-29 2019-05-02 삼성전자주식회사 링커 폴리펩티드 및 이를 이용한 표적 물질 분석 방법
EP3641891A4 (en) 2017-06-22 2021-01-27 William Marsh Rice University SYNTHESIS OF DISORAZOLES AND THEIR ANALOGUES AS POWERFUL ANTI-CANCER AGENTS

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214969B1 (en) 1988-10-21 2001-04-10 The Administrators Of The Tulane Educational Fund Luteinizing hormone releasing hormone analogs with cytotoxic moiety
US5866679A (en) 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
WO1998010651A1 (en) 1996-09-12 1998-03-19 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
DE19728737C1 (de) 1997-07-04 1999-02-11 Johannes Christian Groeninghen Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten
AU740597B2 (en) 1997-07-10 2001-11-08 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
BR0313789A (pt) 2002-08-24 2005-07-05 Zentaris Gmbh Medicamento contendo disorazóis e seus derivados para o tratamento de doenças tumorais malignas e benignas
AU2003298864A1 (en) 2002-12-06 2004-06-30 Kosan Biosciences, Inc. Disorazole polyketide synthase encoding polynucleotides
WO2005112919A2 (en) * 2004-05-19 2005-12-01 Medarex, Inc. Self-immolative linkers and drug conjugates
US20060199252A1 (en) 2005-01-13 2006-09-07 Herbert Irschik Genes encoding the synthetic pathway for the production of disorazole
WO2006075013A1 (en) 2005-01-13 2006-07-20 Helmholtz-Zentrum für Infektionsforschung GmbH Genes encoding the synthetic pathway for the production of disorazole
WO2006135371A1 (en) * 2005-06-09 2006-12-21 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
EP1743897A1 (en) * 2005-07-15 2007-01-17 Gesellschaft für Biotechnologische Forschung mbH Biologically active compounds obtainable from Sorangium cellulosum
EP1900742A1 (en) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof

Also Published As

Publication number Publication date
AR062685A1 (es) 2008-11-26
TW200823228A (en) 2008-06-01
AU2007293650A1 (en) 2008-03-13
CA2662308C (en) 2014-10-28
MX2009002483A (es) 2009-03-23
EP2066679B1 (en) 2016-03-09
US7741277B2 (en) 2010-06-22
KR101532966B1 (ko) 2015-07-02
US20100323963A1 (en) 2010-12-23
SI2066679T1 (sl) 2016-06-30
RS54857B1 (sr) 2016-10-31
NZ575032A (en) 2011-02-25
AU2007293650B2 (en) 2012-06-14
US20100317580A1 (en) 2010-12-16
US8470776B2 (en) 2013-06-25
TWI346116B (en) 2011-08-01
PL2066679T3 (pl) 2016-09-30
CA2662308A1 (en) 2008-03-13
DK2066679T3 (en) 2016-06-27
HUE028061T2 (en) 2016-11-28
ES2572183T3 (es) 2016-05-30
RU2009112546A (ru) 2010-10-20
EP1900742A1 (en) 2008-03-19
KR20090064436A (ko) 2009-06-18
WO2008028934A8 (en) 2008-05-02
EP2066679A1 (en) 2009-06-10
WO2008028934A1 (en) 2008-03-13
US20080090758A1 (en) 2008-04-17

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