RS54857B1 - Konjugati disorazola i njihovih derivata sa molekulima koji se vezuju za ćeliju, novi derivati disorazola, postupci za proizvodnju i njihova upotreba - Google Patents
Konjugati disorazola i njihovih derivata sa molekulima koji se vezuju za ćeliju, novi derivati disorazola, postupci za proizvodnju i njihova upotrebaInfo
- Publication number
- RS54857B1 RS54857B1 RS20160412A RSP20160412A RS54857B1 RS 54857 B1 RS54857 B1 RS 54857B1 RS 20160412 A RS20160412 A RS 20160412A RS P20160412 A RSP20160412 A RS P20160412A RS 54857 B1 RS54857 B1 RS 54857B1
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- group
- independently selected
- heterocyclyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Jedinjenje formule (I) ili (IV)C1 -B1 -A-B2-C2 (I),C1 - B1 -A (IV),gde za (I) i (IV) :A je disorazolni ostatak prema formuli (III)gde:Rio, Rjo, Rkp, Rmp, R28, R30, R31, R32, R33, R34, R35, R36, R38, R40, R41, R42, R43, R44 su vodonik;RIp, Rnp zajedno obrazuju dvostruku vezu ili su nezavisno izabrani iz grupe koju "vodonik, alkoksil";R27, R29 zajedno obrazuju dvostruku vezu ili eposkid (oksiran);R37, R39 zajedno obrazuju dvostruku vezu ili epoksid (oksiran);R25, R26 su nezavisno jedan od drugog izabrani iz grupe koju čine: "alkil" koji je opciono supstituisan kao alkil grupa sa 1, 2 ili 3 supstituenta nezavisno izabrana jedan od drugog iz grupe koju čine "alkil, cikloalkil, cikloalkil-alkil, aril, heteroaril, aril-alkil, heteroaril-alkil, heterociklil, heterociklil-alkil, alkilsulfonil, arilsulfonil, aril-alkilsulfonil, -F, -Cl, -Br, -I, -N3, -NO2, =O, =S, =S(O)2, hidroksil, acetil, karboksil, karboksilestar, amid, karbonat, karbamat, ostaci alfa-amino kiselina, ostaci beta-amino kiselina, alkoksil, amino, hidroksilamino, mono-alkiiamino, di-alkiiamino, hidrazinil, cijano, cijano-alkii, sulfhidril, disulfidilatkil i/ili alkil-sulfidil";B1 i/ili B2 su nezavisno jedan od drugog izabrani iz grupe koju čine "vezujuća grupa ostatkadikarbonske kiseline, sukcinii, glutaril";C1 i/ili C2 su nezavisno jedan od drugog izabrani iz grupe koju čine "LHRH, [D-Lys6] LHRH, somatostatin, somatostatin analozi, humani albumin iz seruma (HSA)";o je 1 ili 2; p je 1 ili 2;gde izraz "alkil" uključuje aciklične zasićene, delimično nezasićene ili zasićene ugljovodonike koje imaju C1-C12 ugljenikove atome, koji mogu biti ravnolančani ili razgranati i mogu sadržati jednu ili više dvostrukih veza i/ili jednu ili više trostrukih veza; ' gde se izraz "alkoksil" odnosi na radikale u kojima "alkil", "cikloalkil", "cikloalkil-alkil", "aril", "arilalkil", "heteroaril", "heteroaril-alkil", "heterociklil" i/ili "heterociklil-alkil" grupa je vezana preko atoma kiseonika (-O-grupa).Prijava sadrži još 16 patentnih zahteva.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84235706P | 2006-09-06 | 2006-09-06 | |
| EP06018750A EP1900742A1 (en) | 2006-09-07 | 2006-09-07 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
| PCT/EP2007/059310 WO2008028934A1 (en) | 2006-09-06 | 2007-09-06 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
| EP07803270.3A EP2066679B1 (en) | 2006-09-06 | 2007-09-06 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS54857B1 true RS54857B1 (sr) | 2016-10-31 |
Family
ID=37670733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20160412A RS54857B1 (sr) | 2006-09-06 | 2007-09-06 | Konjugati disorazola i njihovih derivata sa molekulima koji se vezuju za ćeliju, novi derivati disorazola, postupci za proizvodnju i njihova upotreba |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7741277B2 (sr) |
| EP (2) | EP1900742A1 (sr) |
| KR (1) | KR101532966B1 (sr) |
| AR (1) | AR062685A1 (sr) |
| AU (1) | AU2007293650B2 (sr) |
| CA (1) | CA2662308C (sr) |
| DK (1) | DK2066679T3 (sr) |
| ES (1) | ES2572183T3 (sr) |
| HU (1) | HUE028061T2 (sr) |
| MX (2) | MX2009002483A (sr) |
| NZ (1) | NZ575032A (sr) |
| PL (1) | PL2066679T3 (sr) |
| RS (1) | RS54857B1 (sr) |
| SI (1) | SI2066679T1 (sr) |
| TW (1) | TWI346116B (sr) |
| WO (1) | WO2008028934A1 (sr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1900742A1 (en) | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
| WO2010033207A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
| WO2010033224A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
| CN102325545A (zh) * | 2009-02-20 | 2012-01-18 | 益普生制药股份有限公司 | 具有神经肽y受体结合化合物的细胞毒性缀合物 |
| US20120004182A1 (en) * | 2010-07-02 | 2012-01-05 | Carsten Gruendker | Pharmaceutical compositions and methods for induction and enhancement of apoptosis in tumor cells |
| CN104246497B (zh) * | 2012-03-18 | 2017-10-13 | 国立大学法人九州大学 | 疾病样品分析装置、分析系统及分析方法 |
| KR101974583B1 (ko) | 2012-08-29 | 2019-05-02 | 삼성전자주식회사 | 링커 폴리펩티드 및 이를 이용한 표적 물질 분석 방법 |
| US11465997B2 (en) | 2017-06-22 | 2022-10-11 | William Marsh Rice University | Synthesis of disorazoles and analogs thereof as potent anticancer agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214969B1 (en) | 1988-10-21 | 2001-04-10 | The Administrators Of The Tulane Educational Fund | Luteinizing hormone releasing hormone analogs with cytotoxic moiety |
| US5866679A (en) | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| JP2001501601A (ja) | 1996-09-12 | 2001-02-06 | メルク エンド カンパニー インコーポレーテッド | 前立腺ガンの治療において有用な共役体 |
| DE19728737C1 (de) | 1997-07-04 | 1999-02-11 | Johannes Christian Groeninghen | Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten |
| WO1999002175A1 (en) | 1997-07-10 | 1999-01-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| EP1536789A1 (de) | 2002-08-24 | 2005-06-08 | Zentaris GmbH | Arzneimittel enthaltend disorale und ihre derivate und deren anwendung zur behandlung gutartiger und bösartiger tumorerkrankngen |
| AU2003298864A1 (en) | 2002-12-06 | 2004-06-30 | Kosan Biosciences, Inc. | Disorazole polyketide synthase encoding polynucleotides |
| US7517903B2 (en) * | 2004-05-19 | 2009-04-14 | Medarex, Inc. | Cytotoxic compounds and conjugates |
| US20060199252A1 (en) | 2005-01-13 | 2006-09-07 | Herbert Irschik | Genes encoding the synthetic pathway for the production of disorazole |
| WO2006075013A1 (en) | 2005-01-13 | 2006-07-20 | Helmholtz-Zentrum für Infektionsforschung GmbH | Genes encoding the synthetic pathway for the production of disorazole |
| WO2006135371A1 (en) * | 2005-06-09 | 2006-12-21 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
| EP1743897A1 (en) * | 2005-07-15 | 2007-01-17 | Gesellschaft für Biotechnologische Forschung mbH | Biologically active compounds obtainable from Sorangium cellulosum |
| EP1900742A1 (en) | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
-
2006
- 2006-09-07 EP EP06018750A patent/EP1900742A1/en not_active Withdrawn
-
2007
- 2007-09-06 WO PCT/EP2007/059310 patent/WO2008028934A1/en active Application Filing
- 2007-09-06 KR KR1020097007093A patent/KR101532966B1/ko not_active IP Right Cessation
- 2007-09-06 AR ARP070103942A patent/AR062685A1/es not_active Application Discontinuation
- 2007-09-06 ES ES07803270T patent/ES2572183T3/es active Active
- 2007-09-06 NZ NZ575032A patent/NZ575032A/en not_active IP Right Cessation
- 2007-09-06 DK DK07803270.3T patent/DK2066679T3/en active
- 2007-09-06 TW TW096133272A patent/TWI346116B/zh not_active IP Right Cessation
- 2007-09-06 EP EP07803270.3A patent/EP2066679B1/en active Active
- 2007-09-06 RS RS20160412A patent/RS54857B1/sr unknown
- 2007-09-06 PL PL07803270.3T patent/PL2066679T3/pl unknown
- 2007-09-06 SI SI200731775A patent/SI2066679T1/sl unknown
- 2007-09-06 CA CA2662308A patent/CA2662308C/en not_active Expired - Fee Related
- 2007-09-06 US US11/850,747 patent/US7741277B2/en not_active Expired - Fee Related
- 2007-09-06 HU HUE07803270A patent/HUE028061T2/en unknown
- 2007-09-06 AU AU2007293650A patent/AU2007293650B2/en not_active Ceased
- 2007-09-06 MX MX2009002483A patent/MX2009002483A/es active IP Right Grant
- 2007-09-06 MX MX2011010178A patent/MX337358B/es unknown
-
2010
- 2010-03-19 US US12/728,075 patent/US20100323963A1/en not_active Abandoned
- 2010-03-19 US US12/728,050 patent/US8470776B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2066679A1 (en) | 2009-06-10 |
| CA2662308A1 (en) | 2008-03-13 |
| ES2572183T3 (es) | 2016-05-30 |
| TW200823228A (en) | 2008-06-01 |
| US20080090758A1 (en) | 2008-04-17 |
| MX2009002483A (es) | 2009-03-23 |
| RU2009112546A (ru) | 2010-10-20 |
| CA2662308C (en) | 2014-10-28 |
| WO2008028934A1 (en) | 2008-03-13 |
| US20100323963A1 (en) | 2010-12-23 |
| PL2066679T3 (pl) | 2016-09-30 |
| US20100317580A1 (en) | 2010-12-16 |
| HUE028061T2 (en) | 2016-11-28 |
| US8470776B2 (en) | 2013-06-25 |
| SI2066679T1 (sl) | 2016-06-30 |
| EP2066679B1 (en) | 2016-03-09 |
| AU2007293650B2 (en) | 2012-06-14 |
| NZ575032A (en) | 2011-02-25 |
| EP1900742A1 (en) | 2008-03-19 |
| WO2008028934A8 (en) | 2008-05-02 |
| MX337358B (es) | 2016-02-29 |
| DK2066679T3 (en) | 2016-06-27 |
| US7741277B2 (en) | 2010-06-22 |
| KR20090064436A (ko) | 2009-06-18 |
| KR101532966B1 (ko) | 2015-07-02 |
| AU2007293650A1 (en) | 2008-03-13 |
| TWI346116B (en) | 2011-08-01 |
| AR062685A1 (es) | 2008-11-26 |
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