TWI346116B - Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof - Google Patents
Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereofInfo
- Publication number
- TWI346116B TWI346116B TW096133272A TW96133272A TWI346116B TW I346116 B TWI346116 B TW I346116B TW 096133272 A TW096133272 A TW 096133272A TW 96133272 A TW96133272 A TW 96133272A TW I346116 B TWI346116 B TW I346116B
- Authority
- TW
- Taiwan
- Prior art keywords
- derivatives
- disorazoles
- conjugates
- processes
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84235706P | 2006-09-06 | 2006-09-06 | |
EP06018750A EP1900742A1 (en) | 2006-09-07 | 2006-09-07 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200823228A TW200823228A (en) | 2008-06-01 |
TWI346116B true TWI346116B (en) | 2011-08-01 |
Family
ID=37670733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW096133272A TWI346116B (en) | 2006-09-06 | 2007-09-06 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
Country Status (16)
Country | Link |
---|---|
US (3) | US7741277B2 (zh) |
EP (2) | EP1900742A1 (zh) |
KR (1) | KR101532966B1 (zh) |
AR (1) | AR062685A1 (zh) |
AU (1) | AU2007293650B2 (zh) |
CA (1) | CA2662308C (zh) |
DK (1) | DK2066679T3 (zh) |
ES (1) | ES2572183T3 (zh) |
HU (1) | HUE028061T2 (zh) |
MX (2) | MX2009002483A (zh) |
NZ (1) | NZ575032A (zh) |
PL (1) | PL2066679T3 (zh) |
RS (1) | RS54857B1 (zh) |
SI (1) | SI2066679T1 (zh) |
TW (1) | TWI346116B (zh) |
WO (1) | WO2008028934A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1900742A1 (en) | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
WO2010033224A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
EP2898900B1 (en) | 2008-09-19 | 2017-11-15 | Nektar Therapeutics | Polymer conjugates of ziconotide |
AU2010216372B2 (en) * | 2009-02-20 | 2013-06-20 | Ipsen Pharma S.A.S. | Cytotoxic conjugates having neuropeptide Y receptor binding compound |
US20120004182A1 (en) * | 2010-07-02 | 2012-01-05 | Carsten Gruendker | Pharmaceutical compositions and methods for induction and enhancement of apoptosis in tumor cells |
EP3663758A1 (en) * | 2012-03-18 | 2020-06-10 | Shiseido Company, Ltd. | Apparatus, system and method for analyzing disease sample |
KR101974583B1 (ko) | 2012-08-29 | 2019-05-02 | 삼성전자주식회사 | 링커 폴리펩티드 및 이를 이용한 표적 물질 분석 방법 |
US11465997B2 (en) | 2017-06-22 | 2022-10-11 | William Marsh Rice University | Synthesis of disorazoles and analogs thereof as potent anticancer agents |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214969B1 (en) | 1988-10-21 | 2001-04-10 | The Administrators Of The Tulane Educational Fund | Luteinizing hormone releasing hormone analogs with cytotoxic moiety |
US5866679A (en) | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
AU715632B2 (en) | 1996-09-12 | 2000-02-03 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
DE19728737C1 (de) | 1997-07-04 | 1999-02-11 | Johannes Christian Groeninghen | Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten |
CA2295860A1 (en) | 1997-07-10 | 1999-01-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
NZ538926A (en) | 2002-08-24 | 2006-03-31 | Zentaris Gmbh | Medicament containing disorazoles and derivatives thereof for the treatment of benign and malignant tumoral diseases |
AU2003298864A1 (en) | 2002-12-06 | 2004-06-30 | Kosan Biosciences, Inc. | Disorazole polyketide synthase encoding polynucleotides |
EP1747021B1 (en) * | 2004-05-19 | 2015-09-09 | E. R. Squibb & Sons, L.L.C. | Self-immolative linkers and drug conjugates |
CA2594790A1 (en) | 2005-01-13 | 2006-07-20 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | Genes encoding the synthetic pathway for the production of disorazole |
US20060199252A1 (en) | 2005-01-13 | 2006-09-07 | Herbert Irschik | Genes encoding the synthetic pathway for the production of disorazole |
WO2006135371A1 (en) * | 2005-06-09 | 2006-12-21 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
EP1743897A1 (en) * | 2005-07-15 | 2007-01-17 | Gesellschaft für Biotechnologische Forschung mbH | Biologically active compounds obtainable from Sorangium cellulosum |
EP1900742A1 (en) | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
-
2006
- 2006-09-07 EP EP06018750A patent/EP1900742A1/en not_active Withdrawn
-
2007
- 2007-09-06 SI SI200731775A patent/SI2066679T1/sl unknown
- 2007-09-06 KR KR1020097007093A patent/KR101532966B1/ko not_active IP Right Cessation
- 2007-09-06 MX MX2009002483A patent/MX2009002483A/es active IP Right Grant
- 2007-09-06 EP EP07803270.3A patent/EP2066679B1/en active Active
- 2007-09-06 AR ARP070103942A patent/AR062685A1/es not_active Application Discontinuation
- 2007-09-06 NZ NZ575032A patent/NZ575032A/en not_active IP Right Cessation
- 2007-09-06 DK DK07803270.3T patent/DK2066679T3/en active
- 2007-09-06 AU AU2007293650A patent/AU2007293650B2/en not_active Ceased
- 2007-09-06 HU HUE07803270A patent/HUE028061T2/en unknown
- 2007-09-06 TW TW096133272A patent/TWI346116B/zh not_active IP Right Cessation
- 2007-09-06 RS RS20160412A patent/RS54857B1/sr unknown
- 2007-09-06 PL PL07803270.3T patent/PL2066679T3/pl unknown
- 2007-09-06 US US11/850,747 patent/US7741277B2/en not_active Expired - Fee Related
- 2007-09-06 ES ES07803270T patent/ES2572183T3/es active Active
- 2007-09-06 WO PCT/EP2007/059310 patent/WO2008028934A1/en active Application Filing
- 2007-09-06 MX MX2011010178A patent/MX337358B/es unknown
- 2007-09-06 CA CA2662308A patent/CA2662308C/en not_active Expired - Fee Related
-
2010
- 2010-03-19 US US12/728,075 patent/US20100323963A1/en not_active Abandoned
- 2010-03-19 US US12/728,050 patent/US8470776B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ575032A (en) | 2011-02-25 |
DK2066679T3 (en) | 2016-06-27 |
MX337358B (es) | 2016-02-29 |
SI2066679T1 (sl) | 2016-06-30 |
WO2008028934A1 (en) | 2008-03-13 |
AU2007293650B2 (en) | 2012-06-14 |
TW200823228A (en) | 2008-06-01 |
ES2572183T3 (es) | 2016-05-30 |
AU2007293650A1 (en) | 2008-03-13 |
WO2008028934A8 (en) | 2008-05-02 |
RU2009112546A (ru) | 2010-10-20 |
US7741277B2 (en) | 2010-06-22 |
US20080090758A1 (en) | 2008-04-17 |
AR062685A1 (es) | 2008-11-26 |
US20100323963A1 (en) | 2010-12-23 |
HUE028061T2 (en) | 2016-11-28 |
KR101532966B1 (ko) | 2015-07-02 |
US20100317580A1 (en) | 2010-12-16 |
EP2066679A1 (en) | 2009-06-10 |
CA2662308A1 (en) | 2008-03-13 |
PL2066679T3 (pl) | 2016-09-30 |
KR20090064436A (ko) | 2009-06-18 |
CA2662308C (en) | 2014-10-28 |
EP2066679B1 (en) | 2016-03-09 |
RS54857B1 (sr) | 2016-10-31 |
US8470776B2 (en) | 2013-06-25 |
EP1900742A1 (en) | 2008-03-19 |
MX2009002483A (es) | 2009-03-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2395012B8 (en) | Modified siRNA molecules and uses thereof | |
EP2067782A4 (en) | HETERACENE DERIVATIVE, TETRAHALOTHERPHENYL DERIVATIVE, AND PROCESSES FOR PRODUCING THE SAME | |
AU2007313300A8 (en) | Molecules with reduced half-lives, compositions and uses thereof | |
IL195245A0 (en) | Substituted prolinamides, production thereof and their use as drugs | |
EP2268813A4 (en) | RNA MOLECULES AND THEIR USE | |
IL195876A0 (en) | Pyrazine derivatives with extended conjugation and uses thereof | |
HK1140202A1 (en) | Novel pyridopyrazine derivatives, process of manufacturing and uses thereof | |
IL218716A0 (en) | Methods of selecting and producing modified toxins, conjugates containing modified toxins and uses thereof | |
IL189187A (en) | Polymeric couplings of a252-k and their history, their pharmaceutical preparations and their uses | |
EP1990337A4 (en) | CHINAZOLINE DERIVATIVES, METHOD OF MANUFACTURE AND USES THEREOF | |
TWI346116B (en) | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof | |
ZA201001206B (en) | Saccharide-containing protein conjugates and uses thereof | |
GB0808916D0 (en) | Production of conjugates | |
IL206060A0 (en) | Conjugates of anti-rg-1 antibodies, compositions comprising the same and uses thereof | |
EP2040242A4 (en) | FOLDABLE LABEL, ARTICLE WITH FOLDABLE LABEL, AND METHOD OF MANUFACTURING THE ARTICLE | |
IL196866A (en) | Erythropoietin compounds, pharmaceuticals containing them and their uses | |
ZA200900302B (en) | Composition, article, its manufacture and use | |
IL195430A0 (en) | Arylsulfonamidyl tetralin derivatives and uses thereof | |
HRP20160631T1 (hr) | Konjugati disorazola i njihovi derivati sa staničnovezajućim molekulama, novi derivati disorazola, postupci njihove pripreme i njihove uporabe | |
ZA200901177B (en) | Conjugates of disorazoles and their derivatives with cellbinding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof | |
GB2469959B (en) | Dioctatin derivatives and production process thereof | |
AU2007905753A0 (en) | Novel Immunogenic Molecules and Uses Thereof | |
GB0616531D0 (en) | The medicinal uses of molecules and their derivatives | |
ZA200808225B (en) | Substituted prolinamides, production thereof and their use as drugs | |
GB0715513D0 (en) | The medicinal uses of molecules and their derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |