WO2009150381A3 - Derives d'azacarbolines, leur preparation et leur utilisation therapeutique en tant qu'inhibiteurs de kinases - Google Patents
Derives d'azacarbolines, leur preparation et leur utilisation therapeutique en tant qu'inhibiteurs de kinases Download PDFInfo
- Publication number
- WO2009150381A3 WO2009150381A3 PCT/FR2009/051100 FR2009051100W WO2009150381A3 WO 2009150381 A3 WO2009150381 A3 WO 2009150381A3 FR 2009051100 W FR2009051100 W FR 2009051100W WO 2009150381 A3 WO2009150381 A3 WO 2009150381A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- branched
- heterocycloalkyl
- therapeutic use
- linear
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201170002A EA018945B1 (ru) | 2008-06-12 | 2009-06-11 | Производные азакарболинов, способ их получения и применение в терапии |
AU2009259114A AU2009259114B2 (en) | 2008-06-12 | 2009-06-11 | Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors |
EP09761932A EP2303882A2 (fr) | 2008-06-12 | 2009-06-11 | Derives d'azacarbolines, leur preparation et leur utilisation therapeutique en tant qu'inhibiteurs de kinases |
MX2010013699A MX2010013699A (es) | 2008-06-12 | 2009-06-11 | Derivados de azacarbolinas, su preparacion y su uso terapeutico. |
JP2011513034A JP2011522867A (ja) | 2008-06-12 | 2009-06-11 | アザカルボリン誘導体、この調製およびキナーゼ阻害剤としてのこの治療上の使用 |
UAA201100324A UA101668C2 (ru) | 2008-06-12 | 2009-06-11 | Производные азакарболинов, способ их получения и применения в терапии |
NZ589839A NZ589839A (en) | 2008-06-12 | 2009-06-11 | Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors |
CN2009801313693A CN102124007A (zh) | 2008-06-12 | 2009-06-11 | 氮杂咔啉衍生物、其制备方法和其作为激酶抑制剂的治疗用途 |
BRPI0915204A BRPI0915204A2 (pt) | 2008-06-12 | 2009-06-11 | derivados de azacarbolinas, a respectiva preparação e sua utilização terapêutica |
CA2725093A CA2725093A1 (fr) | 2008-06-12 | 2009-06-11 | Derives d'azacarbolines, leur preparation et leur utilisation therapeutique |
US12/997,326 US20110178053A1 (en) | 2008-06-12 | 2009-06-11 | Azacarboline derivatives, preparation method thereof and therapeutic use of same |
TNP2010000529A TN2010000529A1 (fr) | 2009-06-11 | 2010-11-12 | Derives d'azacarbolines, leur preparation et leur utilisation therapeutique en tant qu'inhibiteurs de kinases |
ZA2010/08387A ZA201008387B (en) | 2008-06-12 | 2010-11-23 | Azacarboline derivatives,preparation thereof,and therapeutic use thereof as kinase inhibitors |
IL209840A IL209840A0 (en) | 2008-06-12 | 2010-12-08 | Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors |
MA33499A MA32460B1 (fr) | 2008-06-12 | 2011-01-07 | Derives d'azacarbolines, leur preparation et leur utilisation therapeutique en tant qu'inhibiteurs de kinases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0803262 | 2008-06-12 | ||
FR08/03262 | 2008-06-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009150381A2 WO2009150381A2 (fr) | 2009-12-17 |
WO2009150381A3 true WO2009150381A3 (fr) | 2010-02-18 |
Family
ID=40445526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2009/051100 WO2009150381A2 (fr) | 2008-06-12 | 2009-06-11 | Derives d'azacarbolines, leur preparation et leur utilisation therapeutique |
Country Status (26)
Country | Link |
---|---|
US (1) | US20110178053A1 (fr) |
EP (1) | EP2303882A2 (fr) |
JP (1) | JP2011522867A (fr) |
KR (1) | KR20110016998A (fr) |
CN (1) | CN102124007A (fr) |
AR (1) | AR072084A1 (fr) |
AU (1) | AU2009259114B2 (fr) |
BR (1) | BRPI0915204A2 (fr) |
CA (1) | CA2725093A1 (fr) |
CO (1) | CO6280536A2 (fr) |
CR (1) | CR11814A (fr) |
DO (1) | DOP2010000366A (fr) |
EA (1) | EA018945B1 (fr) |
EC (1) | ECSP10010670A (fr) |
IL (1) | IL209840A0 (fr) |
MA (1) | MA32460B1 (fr) |
MX (1) | MX2010013699A (fr) |
NI (1) | NI201000210A (fr) |
NZ (1) | NZ589839A (fr) |
PE (1) | PE20110122A1 (fr) |
SV (1) | SV2010003754A (fr) |
TW (1) | TW201002711A (fr) |
UA (1) | UA101668C2 (fr) |
UY (1) | UY31895A (fr) |
WO (1) | WO2009150381A2 (fr) |
ZA (1) | ZA201008387B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2706059A1 (fr) | 2008-06-11 | 2014-03-12 | Genentech, Inc. | Diazacarbazoles et procédés d'utilisation |
BRPI0915720A2 (pt) | 2008-06-12 | 2015-08-04 | Janssen Pharmaceutica Nv | Moduladores de diaminopiridina, pirimidina, e piridazina do receptor de histamina h4 |
FR2950891B1 (fr) * | 2009-10-06 | 2012-11-09 | Sanofi Aventis | Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique |
AR073431A1 (es) * | 2009-03-24 | 2010-11-03 | Sanofi Aventis | Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica |
FR2953838B1 (fr) * | 2009-12-10 | 2012-02-24 | Sanofi Aventis | Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique |
US20110183938A1 (en) * | 2009-12-16 | 2011-07-28 | Genentech, Inc. | 1,7-diazacarbazoles and methods of use |
AU2014249192B2 (en) * | 2013-03-11 | 2017-12-21 | The Regents Of The University Of Michigan | BET bromodomain inhibitors and therapeutic methods using the same |
KR101652577B1 (ko) * | 2013-04-19 | 2016-08-30 | 영남대학교 산학협력단 | 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물 |
CN103408573B (zh) * | 2013-07-12 | 2015-12-23 | 上海工程技术大学 | 硼酸衍生物及其制备方法和应用 |
WO2018137655A1 (fr) * | 2017-01-25 | 2018-08-02 | 江苏豪森药业集团有限公司 | Dérivé de pyrrolo-pyridine n-oxyde, son procédé de préparation et son utilisation |
MX2020001531A (es) * | 2017-08-07 | 2020-03-20 | Biocad Joint Stock Co | Nuevos compuestos hetorociclicos como inhibidores de cdk8/19. |
EP3860996A4 (fr) | 2018-10-02 | 2022-08-31 | Northwestern University | Bêta-carbolines servant de modulateurs allostériques positifs du récepteur humain de la sérotonine 2c (5-ht2c) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007044779A1 (fr) * | 2005-10-07 | 2007-04-19 | Takeda San Diego, Inc. | Inhibiteurs de kinase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2706059A1 (fr) * | 2008-06-11 | 2014-03-12 | Genentech, Inc. | Diazacarbazoles et procédés d'utilisation |
-
2009
- 2009-06-10 AR ARP090102077A patent/AR072084A1/es not_active Application Discontinuation
- 2009-06-11 EA EA201170002A patent/EA018945B1/ru not_active IP Right Cessation
- 2009-06-11 CA CA2725093A patent/CA2725093A1/fr not_active Abandoned
- 2009-06-11 KR KR1020117000721A patent/KR20110016998A/ko not_active Application Discontinuation
- 2009-06-11 EP EP09761932A patent/EP2303882A2/fr not_active Withdrawn
- 2009-06-11 PE PE2010001118A patent/PE20110122A1/es not_active Application Discontinuation
- 2009-06-11 AU AU2009259114A patent/AU2009259114B2/en not_active Ceased
- 2009-06-11 UA UAA201100324A patent/UA101668C2/ru unknown
- 2009-06-11 CN CN2009801313693A patent/CN102124007A/zh active Pending
- 2009-06-11 US US12/997,326 patent/US20110178053A1/en not_active Abandoned
- 2009-06-11 NZ NZ589839A patent/NZ589839A/en not_active IP Right Cessation
- 2009-06-11 MX MX2010013699A patent/MX2010013699A/es active IP Right Grant
- 2009-06-11 JP JP2011513034A patent/JP2011522867A/ja not_active Ceased
- 2009-06-11 WO PCT/FR2009/051100 patent/WO2009150381A2/fr active Application Filing
- 2009-06-11 BR BRPI0915204A patent/BRPI0915204A2/pt not_active IP Right Cessation
- 2009-06-12 TW TW098119820A patent/TW201002711A/zh unknown
- 2009-06-12 UY UY0001031895A patent/UY31895A/es not_active Application Discontinuation
-
2010
- 2010-11-23 ZA ZA2010/08387A patent/ZA201008387B/en unknown
- 2010-11-25 CR CR11814A patent/CR11814A/es not_active Application Discontinuation
- 2010-11-29 DO DO2010000366A patent/DOP2010000366A/es unknown
- 2010-12-03 EC EC2010010670A patent/ECSP10010670A/es unknown
- 2010-12-06 NI NI201000210A patent/NI201000210A/es unknown
- 2010-12-08 IL IL209840A patent/IL209840A0/en unknown
- 2010-12-09 CO CO10154614A patent/CO6280536A2/es active IP Right Grant
- 2010-12-09 SV SV2010003754A patent/SV2010003754A/es unknown
-
2011
- 2011-01-07 MA MA33499A patent/MA32460B1/fr unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007044779A1 (fr) * | 2005-10-07 | 2007-04-19 | Takeda San Diego, Inc. | Inhibiteurs de kinase |
Non-Patent Citations (1)
Title |
---|
CHENEY ET AL: "Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 6, 20 February 2007 (2007-02-20), pages 1679 - 1683, XP005895389, ISSN: 0960-894X * |
Also Published As
Publication number | Publication date |
---|---|
UY31895A (es) | 2010-01-29 |
AU2009259114A1 (en) | 2009-12-17 |
TW201002711A (en) | 2010-01-16 |
CR11814A (es) | 2011-01-10 |
ECSP10010670A (es) | 2011-01-31 |
PE20110122A1 (es) | 2011-03-07 |
US20110178053A1 (en) | 2011-07-21 |
DOP2010000366A (es) | 2010-12-31 |
CO6280536A2 (es) | 2011-05-20 |
EP2303882A2 (fr) | 2011-04-06 |
NZ589839A (en) | 2012-07-27 |
AU2009259114B2 (en) | 2013-05-23 |
EA018945B1 (ru) | 2013-11-29 |
UA101668C2 (ru) | 2013-04-25 |
BRPI0915204A2 (pt) | 2019-01-15 |
SV2010003754A (es) | 2011-03-15 |
EA201170002A1 (ru) | 2011-08-30 |
JP2011522867A (ja) | 2011-08-04 |
AR072084A1 (es) | 2010-08-04 |
ZA201008387B (en) | 2012-02-29 |
MX2010013699A (es) | 2011-02-23 |
WO2009150381A2 (fr) | 2009-12-17 |
CN102124007A (zh) | 2011-07-13 |
IL209840A0 (en) | 2011-02-28 |
KR20110016998A (ko) | 2011-02-18 |
NI201000210A (es) | 2011-05-09 |
MA32460B1 (fr) | 2011-07-03 |
CA2725093A1 (fr) | 2009-12-17 |
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