SV2010003754A - Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica - Google Patents
Derivados de azacarbolinas, su preparacion y su utilizacion terapeuticaInfo
- Publication number
- SV2010003754A SV2010003754A SV2010003754A SV2010003754A SV2010003754A SV 2010003754 A SV2010003754 A SV 2010003754A SV 2010003754 A SV2010003754 A SV 2010003754A SV 2010003754 A SV2010003754 A SV 2010003754A SV 2010003754 A SV2010003754 A SV 2010003754A
- Authority
- SV
- El Salvador
- Prior art keywords
- optionally replaced
- replaced
- optionally
- heterocicloalquilo
- ramified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
NUEVAS AZACARBOLINAS DE FÓRMULA (I), EN LA QUE: R3, R4 REPRESENTAN INDEPENDIENTEMENTE EL UNO DEL OTRO H; HAL; CF3; OXI SUSTITUIDO; ALCOXI OPCIONALMENTE SUSTITUIDO; AMINO OPCIONALMENTE SUSTITUIDO; CARBONILO SUSTITUIDO; CARBOXILO OPCIONALMENTE SUSTITUIDO; AMIDA OPCIONALMENTE SUSTITUIDA; AZUFRE TALES COMO SULFUROS, SULFÓXIDOS O SULFONAS OPCIONALMENTE SUSTITUIDOS; ALQUILO C1-C10 LINEAL, RAMIFICADO O CÍCLICO QUE CONTIENE OPCIONALMENTE UN HETEROÁTOMO OPCIONALMENTE SUSTITUIDO; ALQUENILO C2-C7 LINEAL, RAMIFICADO O CÍCLICO OPCIONALMENTE SUSTITUIDO; ALQUINILO C2-C6 LINEAL O RAMIFICADO OPCIONALMENTE SUSTITUIDO; ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO; HETEROCICLOALQUILO OPCIONALMENTE SUSTITUIDO; R6 REPRESENTA HETEROARILO, C(O)NR1AR1B, HETEROCICLOALQUILO O C(O)HETEROCICLOALQUILO TODOS OPCIONALMENTE SUSTITUIDOS; EN EL ESTADO DE BASE O DE SAL DE ADICIÓN A UN ÁCIDO. UTILIZACIÓN EN TERAPÉUTICA PARA EL TRATAMIENTO DEL CÁNCER Y PROCEDIMIENTOS DE SÍNTESIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0803262 | 2008-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2010003754A true SV2010003754A (es) | 2011-03-15 |
Family
ID=40445526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2010003754A SV2010003754A (es) | 2008-06-12 | 2010-12-09 | Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20110178053A1 (es) |
| EP (1) | EP2303882A2 (es) |
| JP (1) | JP2011522867A (es) |
| KR (1) | KR20110016998A (es) |
| CN (1) | CN102124007A (es) |
| AR (1) | AR072084A1 (es) |
| AU (1) | AU2009259114B2 (es) |
| BR (1) | BRPI0915204A2 (es) |
| CA (1) | CA2725093A1 (es) |
| CO (1) | CO6280536A2 (es) |
| CR (1) | CR11814A (es) |
| DO (1) | DOP2010000366A (es) |
| EA (1) | EA018945B1 (es) |
| EC (1) | ECSP10010670A (es) |
| IL (1) | IL209840A0 (es) |
| MA (1) | MA32460B1 (es) |
| MX (1) | MX2010013699A (es) |
| NI (1) | NI201000210A (es) |
| NZ (1) | NZ589839A (es) |
| PE (1) | PE20110122A1 (es) |
| SV (1) | SV2010003754A (es) |
| TW (1) | TW201002711A (es) |
| UA (1) | UA101668C2 (es) |
| UY (1) | UY31895A (es) |
| WO (1) | WO2009150381A2 (es) |
| ZA (1) | ZA201008387B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2706059A1 (en) | 2008-06-11 | 2014-03-12 | Genentech, Inc. | Diazacarbazoles and methods of use |
| NZ589532A (en) | 2008-06-12 | 2012-02-24 | Janssen Pharmaceutica Nv | Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor |
| FR2950891B1 (fr) * | 2009-10-06 | 2012-11-09 | Sanofi Aventis | Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique |
| AU2009342734A1 (en) * | 2009-03-24 | 2011-10-13 | Sanofi | 9H-pyrrolo[2,3-b: 5,4-c'] dipyridine azacarboline derivatives, preparation thereof, and therapeutic use thereof |
| FR2953838B1 (fr) * | 2009-12-10 | 2012-02-24 | Sanofi Aventis | Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique |
| US20110183938A1 (en) * | 2009-12-16 | 2011-07-28 | Genentech, Inc. | 1,7-diazacarbazoles and methods of use |
| CN105377851B (zh) * | 2013-03-11 | 2018-07-20 | 密执安州立大学董事会 | Bet布罗莫结构域抑制剂和使用这些抑制剂的治疗方法 |
| KR101612179B1 (ko) * | 2013-04-19 | 2016-04-12 | 영남대학교 산학협력단 | 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물 |
| CN103408573B (zh) * | 2013-07-12 | 2015-12-23 | 上海工程技术大学 | 硼酸衍生物及其制备方法和应用 |
| CN110198941B (zh) * | 2017-01-25 | 2021-09-28 | 江苏豪森药业集团有限公司 | 吡咯并吡啶类n-氧化衍生物及其制备方法和应用 |
| MX2020001531A (es) * | 2017-08-07 | 2020-03-20 | Biocad Joint Stock Co | Nuevos compuestos hetorociclicos como inhibidores de cdk8/19. |
| US11485734B2 (en) | 2018-10-02 | 2022-11-01 | Northwestern University | Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| EP2706059A1 (en) * | 2008-06-11 | 2014-03-12 | Genentech, Inc. | Diazacarbazoles and methods of use |
-
2009
- 2009-06-10 AR ARP090102077A patent/AR072084A1/es not_active Application Discontinuation
- 2009-06-11 CA CA2725093A patent/CA2725093A1/fr not_active Abandoned
- 2009-06-11 BR BRPI0915204A patent/BRPI0915204A2/pt not_active IP Right Cessation
- 2009-06-11 PE PE2010001118A patent/PE20110122A1/es not_active Application Discontinuation
- 2009-06-11 AU AU2009259114A patent/AU2009259114B2/en not_active Ceased
- 2009-06-11 WO PCT/FR2009/051100 patent/WO2009150381A2/fr active Application Filing
- 2009-06-11 EP EP09761932A patent/EP2303882A2/fr not_active Withdrawn
- 2009-06-11 NZ NZ589839A patent/NZ589839A/en not_active IP Right Cessation
- 2009-06-11 US US12/997,326 patent/US20110178053A1/en not_active Abandoned
- 2009-06-11 EA EA201170002A patent/EA018945B1/ru not_active IP Right Cessation
- 2009-06-11 UA UAA201100324A patent/UA101668C2/ru unknown
- 2009-06-11 KR KR1020117000721A patent/KR20110016998A/ko not_active Application Discontinuation
- 2009-06-11 JP JP2011513034A patent/JP2011522867A/ja not_active Ceased
- 2009-06-11 CN CN2009801313693A patent/CN102124007A/zh active Pending
- 2009-06-11 MX MX2010013699A patent/MX2010013699A/es active IP Right Grant
- 2009-06-12 TW TW098119820A patent/TW201002711A/zh unknown
- 2009-06-12 UY UY0001031895A patent/UY31895A/es not_active Application Discontinuation
-
2010
- 2010-11-23 ZA ZA2010/08387A patent/ZA201008387B/en unknown
- 2010-11-25 CR CR11814A patent/CR11814A/es not_active Application Discontinuation
- 2010-11-29 DO DO2010000366A patent/DOP2010000366A/es unknown
- 2010-12-03 EC EC2010010670A patent/ECSP10010670A/es unknown
- 2010-12-06 NI NI201000210A patent/NI201000210A/es unknown
- 2010-12-08 IL IL209840A patent/IL209840A0/en unknown
- 2010-12-09 CO CO10154614A patent/CO6280536A2/es active IP Right Grant
- 2010-12-09 SV SV2010003754A patent/SV2010003754A/es unknown
-
2011
- 2011-01-07 MA MA33499A patent/MA32460B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009150381A2 (fr) | 2009-12-17 |
| UY31895A (es) | 2010-01-29 |
| AU2009259114A1 (en) | 2009-12-17 |
| EP2303882A2 (fr) | 2011-04-06 |
| CR11814A (es) | 2011-01-10 |
| CO6280536A2 (es) | 2011-05-20 |
| US20110178053A1 (en) | 2011-07-21 |
| UA101668C2 (ru) | 2013-04-25 |
| BRPI0915204A2 (pt) | 2019-01-15 |
| TW201002711A (en) | 2010-01-16 |
| IL209840A0 (en) | 2011-02-28 |
| AU2009259114B2 (en) | 2013-05-23 |
| NI201000210A (es) | 2011-05-09 |
| CA2725093A1 (fr) | 2009-12-17 |
| AR072084A1 (es) | 2010-08-04 |
| NZ589839A (en) | 2012-07-27 |
| KR20110016998A (ko) | 2011-02-18 |
| EA201170002A1 (ru) | 2011-08-30 |
| MX2010013699A (es) | 2011-02-23 |
| ECSP10010670A (es) | 2011-01-31 |
| EA018945B1 (ru) | 2013-11-29 |
| CN102124007A (zh) | 2011-07-13 |
| DOP2010000366A (es) | 2010-12-31 |
| ZA201008387B (en) | 2012-02-29 |
| MA32460B1 (fr) | 2011-07-03 |
| JP2011522867A (ja) | 2011-08-04 |
| WO2009150381A3 (fr) | 2010-02-18 |
| PE20110122A1 (es) | 2011-03-07 |
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