FR2950891B1 - Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique - Google Patents

Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique

Info

Publication number
FR2950891B1
FR2950891B1 FR0956944A FR0956944A FR2950891B1 FR 2950891 B1 FR2950891 B1 FR 2950891B1 FR 0956944 A FR0956944 A FR 0956944A FR 0956944 A FR0956944 A FR 0956944A FR 2950891 B1 FR2950891 B1 FR 2950891B1
Authority
FR
France
Prior art keywords
dipyridine
pyrrolo
preparation
therapeutic use
azacarboline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0956944A
Other languages
English (en)
Other versions
FR2950891A1 (fr
Inventor
Didier Babin
Olivier Bedel
Thierry Gouyon
Serge Mignani
David Papin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0956944A priority Critical patent/FR2950891B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to UY0001032275A priority patent/UY32275A/es
Priority to BRPI0924844A priority patent/BRPI0924844A2/pt
Priority to MX2011010062A priority patent/MX2011010062A/es
Priority to SG2011068889A priority patent/SG174903A1/en
Priority to AU2009342734A priority patent/AU2009342734A1/en
Priority to JP2012501334A priority patent/JP2012521394A/ja
Priority to PCT/FR2009/052330 priority patent/WO2010109084A2/fr
Priority to TW098140843A priority patent/TW201035097A/zh
Priority to RU2011142791/04A priority patent/RU2011142791A/ru
Priority to EP09797115A priority patent/EP2411389A2/fr
Priority to CA2756152A priority patent/CA2756152A1/fr
Priority to CN2009801583033A priority patent/CN102365282A/zh
Priority to KR1020117024857A priority patent/KR20110130504A/ko
Priority to ARP090104599A priority patent/AR073431A1/es
Priority to US13/258,924 priority patent/US20120208809A1/en
Publication of FR2950891A1 publication Critical patent/FR2950891A1/fr
Priority to IL215286A priority patent/IL215286A0/en
Application granted granted Critical
Publication of FR2950891B1 publication Critical patent/FR2950891B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
FR0956944A 2009-03-24 2009-10-06 Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique Expired - Fee Related FR2950891B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR0956944A FR2950891B1 (fr) 2009-10-06 2009-10-06 Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
CN2009801583033A CN102365282A (zh) 2009-03-24 2009-11-30 9H-吡咯并[2，3-b：5，4-c’]二吡啶氮杂咔啉衍生物、其制备方法及其治疗用途
MX2011010062A MX2011010062A (es) 2009-03-24 2009-11-30 Derivados de azacarbolinas 9h-pirrolo [2,3-b:5,4-c´] dipiridina, su preparacion y su uso en terapeutica.
SG2011068889A SG174903A1 (en) 2009-03-24 2009-11-30 9h-pyrrolo[2,3-b: 5,4-c'] dipyridine azacarboline derivatives, preparation thereof, and therapeutic use thereof
AU2009342734A AU2009342734A1 (en) 2009-03-24 2009-11-30 9H-pyrrolo[2,3-b: 5,4-c'] dipyridine azacarboline derivatives, preparation thereof, and therapeutic use thereof
JP2012501334A JP2012521394A (ja) 2009-03-24 2009-11-30 ９ｈ−ピロロ［２，３−ｂ：５，４−ｃ’］ジピリジンアザカルボリン誘導体、この調製およびこの治療用途
PCT/FR2009/052330 WO2010109084A2 (fr) 2009-03-24 2009-11-30 DERIVES D'AZACARBOLINES 9H-PYRROLO[2,3-b:5,4-c']DIPYRIDINE, LEUR PREPARATION ET LEUR UTILISATION THERAPEUTIQUE
TW098140843A TW201035097A (en) 2009-03-24 2009-11-30 9H-pyrrolo[2,3-b:5,4-c']dipyridine azacarboline derivatives, preparation and therapeutic use thereof
UY0001032275A UY32275A (es) 2009-03-24 2009-11-30 DERIVADOS DE AZACARBOLINAS 9H-PIRROLO[2,3-b:5,4-c'] DIPIRIDINA, SU PREPARACION Y SU UTILIZACIÓN TERAPÉUTICA.
EP09797115A EP2411389A2 (fr) 2009-03-24 2009-11-30 DERIVES D'AZACARBOLINES 9H-PYRROLO[2,3-b:5,4-c']DIPYRIDINE, LEUR PREPARATION ET LEUR UTILISATION THERAPEUTIQUE
CA2756152A CA2756152A1 (fr) 2009-03-24 2009-11-30 Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
BRPI0924844A BRPI0924844A2 (pt) 2009-03-24 2009-11-30 derivados de azacarbolinas 9h-pirrol[2,3-b:5,4-c']dipiridina, sua preparação e sua utilização terapêutica.
KR1020117024857A KR20110130504A (ko) 2009-03-24 2009-11-30 ９ｈ-피롤로〔２,３-ｂ:５,４-ｃ'〕디피리딘 아자카르볼린 유도체, 그의 제조법, 및 그의 치료 용도
ARP090104599A AR073431A1 (es) 2009-03-24 2009-11-30 Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica
US13/258,924 US20120208809A1 (en) 2009-03-24 2009-11-30 9h-pyrrolo[2,3-b: 5,4-c'] dipyridine azacarboline derivatives, preparation thereof, and therapeutic use thereof
RU2011142791/04A RU2011142791A (ru) 2009-03-24 2009-11-30 Производные 9н-пирроло[2,3-b:5,4-с′]дипиридин-азакарболинов, способ их получения и применение в терапии
IL215286A IL215286A0 (en) 2009-03-24 2011-09-21 9h-pyrrolo[2,3-b:5,4-c]dipridine azacarboline derivatives, preparation thereof, and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0956944A FR2950891B1 (fr) 2009-10-06 2009-10-06 Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique

Publications (2)

Publication Number Publication Date
FR2950891A1 FR2950891A1 (fr) 2011-04-08
FR2950891B1 true FR2950891B1 (fr) 2012-11-09

Family

ID=42197736

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0956944A Expired - Fee Related FR2950891B1 (fr) 2009-03-24 2009-10-06 Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique

Country Status (1)

Country Link
FR (1) FR2950891B1 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2081930A2 (fr) * 2006-10-09 2009-07-29 Takeda San Diego, Inc. Inhibiteurs de kinases
CA2666138A1 (fr) * 2006-10-09 2008-05-08 Takeda Pharmaceutical Company Limited Inhibiteurs de kinases
BRPI0813647A2 (pt) * 2007-06-25 2014-12-23 Neurogen Corp Piperazinil oxoalquil tetrahidro-beta-carbolinas e análogos relacionados
WO2009129401A1 (fr) * 2008-04-16 2009-10-22 Takeda Pharmaceutical Company Limited Inhibiteurs de kinases
EP2706059A1 (fr) * 2008-06-11 2014-03-12 Genentech, Inc. Diazacarbazoles et procédés d'utilisation
AR072084A1 (es) * 2008-06-12 2010-08-04 Sanofi Aventis Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica como inhibidores de las quinasas pim

Also Published As

Publication number Publication date
FR2950891A1 (fr) 2011-04-08

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Effective date: 20160630