MX358013B - Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3. - Google Patents

Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.

Info

Publication number
MX358013B
MX358013B MX2016008205A MX2016008205A MX358013B MX 358013 B MX358013 B MX 358013B MX 2016008205 A MX2016008205 A MX 2016008205A MX 2016008205 A MX2016008205 A MX 2016008205A MX 358013 B MX358013 B MX 358013B
Authority
MX
Mexico
Prior art keywords
methods
treating
preventing
agent
associated diseases
Prior art date
Application number
MX2016008205A
Other languages
English (en)
Inventor
Hettmann Thore
j freeman Daniel
Radinsky Robert
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX358013B publication Critical patent/MX358013B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

La presente invención se refiere a el uso de una composición farmacéutica que comprende un primer agente y un segundo agente, para preparar un medicamento para tratar o provenir un cáncer de pulmón asociado con HER-3, en donde el primer agente es una proteína de unión al antígeno que se une a HER-3 que comprende: una secuencia de aminoácidos de cadena pesada que comprende un CDRH1 que tiene una secuencia SEQ ID NO: 256, UN CDRH2 que tiene una secuencia SEQ LID NO: 282 y , un CDRH3 que tiene una secuencia SEQ ID NO: 315 y una secuencia de aminoácidos de cadena ligera que comprende un CDRL1 que tiene una secuencia SEQ ID NO: 340, un CDRL2 que tiene una secuencia SEQ ID NO: 344 y, un CDRL3 que tiene una secuencia SEQ ID NO: 387 y; el segundo agente es lapatinib.
MX2016008205A 2009-11-13 2010-11-12 Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3. MX358013B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26114909P 2009-11-13 2009-11-13
PCT/US2010/056430 WO2011060206A2 (en) 2009-11-13 2010-11-12 Material and methods for treating or preventing her-3 associated diseases

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MX358013B true MX358013B (es) 2018-08-01

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MX2016002120A MX357972B (es) 2009-11-13 2010-11-12 Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
MX2012005589A MX349513B (es) 2009-11-13 2010-11-12 Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
MX2016008205A MX358013B (es) 2009-11-13 2010-11-12 Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.

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MX2012005589A MX349513B (es) 2009-11-13 2010-11-12 Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.

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AR (1) AR080564A1 (es)
AU (1) AU2010319483B2 (es)
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CA (1) CA2780935C (es)
CY (2) CY1119751T1 (es)
DK (2) DK2719708T3 (es)
ES (3) ES2647466T3 (es)
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HR (2) HRP20180104T1 (es)
HU (2) HUE035605T2 (es)
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CN103110948A (zh) 2005-11-04 2013-05-22 惠氏公司 mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合
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