ATE374944T1 - Identifizierung hochaffiner moleküle durch screening mit begrenzter verdünnung - Google Patents
Identifizierung hochaffiner moleküle durch screening mit begrenzter verdünnungInfo
- Publication number
- ATE374944T1 ATE374944T1 AT02792319T AT02792319T ATE374944T1 AT E374944 T1 ATE374944 T1 AT E374944T1 AT 02792319 T AT02792319 T AT 02792319T AT 02792319 T AT02792319 T AT 02792319T AT E374944 T1 ATE374944 T1 AT E374944T1
- Authority
- AT
- Austria
- Prior art keywords
- antigen
- identification
- antibodies
- limited dilution
- molecules
- Prior art date
Links
- 238000010790 dilution Methods 0.000 title abstract 2
- 239000012895 dilution Substances 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Carbon And Carbon Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33725001P | 2001-12-03 | 2001-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE374944T1 true ATE374944T1 (de) | 2007-10-15 |
Family
ID=23319750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02792319T ATE374944T1 (de) | 2001-12-03 | 2002-12-02 | Identifizierung hochaffiner moleküle durch screening mit begrenzter verdünnung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7754433B2 (de) |
| EP (1) | EP1554576B9 (de) |
| AT (1) | ATE374944T1 (de) |
| AU (1) | AU2002357779A1 (de) |
| CA (1) | CA2478547C (de) |
| DE (1) | DE60222816T2 (de) |
| ES (1) | ES2294193T3 (de) |
| WO (1) | WO2003048730A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE374944T1 (de) | 2001-12-03 | 2007-10-15 | Abgenix Inc | Identifizierung hochaffiner moleküle durch screening mit begrenzter verdünnung |
| US7285269B2 (en) | 2002-12-02 | 2007-10-23 | Amgen Fremont, Inc. | Antibodies directed to tumor necrosis factor |
| CA2530172A1 (en) | 2003-06-27 | 2005-02-10 | Abgenix, Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
| JP2008517914A (ja) * | 2004-10-22 | 2008-05-29 | ジェネンコー・インターナショナル・インク | ヒトの抗体の分離方法 |
| WO2006055638A2 (en) | 2004-11-17 | 2006-05-26 | Abgenix, Inc. | Fully human monoclonal antibodies to il-13 |
| CA2605964A1 (en) | 2005-04-20 | 2006-10-26 | Amgen Fremont Inc. | High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies |
| AR056857A1 (es) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| LT2676967T (lt) | 2006-02-28 | 2019-09-10 | Biogen Ma Inc. | Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu |
| AU2007224228B2 (en) | 2006-03-03 | 2013-09-19 | Biogen Ma Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| RU2595409C2 (ru) | 2009-09-03 | 2016-08-27 | Мерк Шарп И Доум Корп., | Анти-gitr-антитела |
| KR101806323B1 (ko) | 2009-11-13 | 2017-12-07 | 다이이치 산쿄 유럽 게엠베하 | Her-3 관련 질병을 치료하거나 예방하기 위한 물질 및 방법 |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| KR102292563B1 (ko) * | 2011-05-31 | 2021-08-24 | 바이오젠 엠에이 인코포레이티드 | Pml의 위험을 판단하는 방법 |
| EA201490974A1 (ru) | 2011-11-16 | 2014-09-30 | Эмджен Инк. | СПОСОБЫ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С ДЕЛЕЦИОННЫМ МУТАНТОМ vIII ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА |
| EP2847219A1 (de) | 2012-05-07 | 2015-03-18 | Amgen Inc. | Anti-erythropoietin-antikörper |
| WO2014193804A1 (en) | 2013-05-28 | 2014-12-04 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
| US10422806B1 (en) * | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
| EP3112869A1 (de) * | 2015-06-30 | 2017-01-04 | IMEC vzw | Sensorvorrichtung |
| EP3532034A4 (de) | 2016-10-28 | 2020-12-02 | Washington University | Anti-apoe-antikörper |
| AU2020323901A1 (en) | 2019-07-26 | 2022-02-24 | Amgen Inc. | Anti-IL13 antigen binding proteins |
| CN114814202A (zh) * | 2022-03-25 | 2022-07-29 | 浙江工业大学 | 一种基于96孔板固载分子马达的传感器检测试剂盒、及其用于p24抗原体外检测的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5800815A (en) * | 1903-05-05 | 1998-09-01 | Cytel Corporation | Antibodies to P-selectin and their uses |
| US5426029A (en) * | 1986-03-31 | 1995-06-20 | T Cell Diagnostics, Inc. | Therapeutic and diagnostic methods using leukocyte surface antigens |
| US5300425A (en) * | 1987-10-13 | 1994-04-05 | Terrapin Technologies, Inc. | Method to produce immunodiagnostic reagents |
| US6165469A (en) * | 1988-01-13 | 2000-12-26 | University Of Virginia | Recombinant Entamoeba histolytica lectin subunit peptides and reagents specific for members of the 170 kD subunit multigene family |
| NO164622C (no) | 1988-05-11 | 1990-10-24 | Tore Lindmo | Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav. |
| AU7165891A (en) * | 1989-12-18 | 1991-07-18 | Board Of Regents, The University Of Texas System | Tumor-specific, cell surface-binding monoclonal antibodies |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| ES2129454T3 (es) * | 1991-08-22 | 1999-06-16 | Becton Dickinson Co | Procedimientos y composiciones de tratamientos de cancer y pronostico de reacciones a los indicados tratamientos. |
| EP1271146A1 (de) | 1991-08-23 | 2003-01-02 | Board Of Regents Of The University Of Nebraska | Verfahren und Zusammensetzungen für zelluläre Reprogrammierung |
| US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| FR2717081B1 (fr) * | 1994-03-14 | 1996-06-21 | Centre Nat Rech Scient | Rétropeptides, anticorps dirigés contre ces derniers, et leurs utilisations pour la vaccination et le diagnostic in vitro. |
| US5656499A (en) * | 1994-08-01 | 1997-08-12 | Abbott Laboratories | Method for performing automated hematology and cytometry analysis |
| US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| US5834597A (en) * | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US6449562B1 (en) | 1996-10-10 | 2002-09-10 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and method |
| US20030118985A1 (en) * | 1997-05-14 | 2003-06-26 | Hunt Jeffrey C. | Mouse monoclonal antibody (5-21-3) to human immunodeficiency virus gp41 protein |
| EP1328808A2 (de) * | 2000-10-20 | 2003-07-23 | Children's Medical Center Corporation | Verfahren zur analyse von dynamischen veränderungen in zelleinformatika |
| US7135296B2 (en) * | 2000-12-28 | 2006-11-14 | Mds Inc. | Elemental analysis of tagged biologically active materials |
| ATE374944T1 (de) | 2001-12-03 | 2007-10-15 | Abgenix Inc | Identifizierung hochaffiner moleküle durch screening mit begrenzter verdünnung |
| EP1466177A4 (de) * | 2001-12-03 | 2005-08-17 | Abgenix Inc | Entdeckung therapeutischer produkte |
-
2002
- 2002-12-02 AT AT02792319T patent/ATE374944T1/de not_active IP Right Cessation
- 2002-12-02 DE DE60222816T patent/DE60222816T2/de not_active Expired - Lifetime
- 2002-12-02 EP EP02792319A patent/EP1554576B9/de not_active Expired - Lifetime
- 2002-12-02 CA CA2478547A patent/CA2478547C/en not_active Expired - Fee Related
- 2002-12-02 ES ES02792319T patent/ES2294193T3/es not_active Expired - Lifetime
- 2002-12-02 AU AU2002357779A patent/AU2002357779A1/en not_active Abandoned
- 2002-12-02 US US10/309,421 patent/US7754433B2/en not_active Expired - Fee Related
- 2002-12-02 WO PCT/US2002/038530 patent/WO2003048730A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1554576A2 (de) | 2005-07-20 |
| CA2478547C (en) | 2011-09-20 |
| DE60222816D1 (de) | 2007-11-15 |
| WO2003048730A2 (en) | 2003-06-12 |
| AU2002357779A8 (en) | 2003-06-17 |
| EP1554576B1 (de) | 2007-10-03 |
| ES2294193T3 (es) | 2008-04-01 |
| DE60222816T2 (de) | 2008-07-03 |
| AU2002357779A1 (en) | 2003-06-17 |
| CA2478547A1 (en) | 2003-06-12 |
| US20030186327A1 (en) | 2003-10-02 |
| US7754433B2 (en) | 2010-07-13 |
| WO2003048730A3 (en) | 2005-05-26 |
| EP1554576B8 (de) | 2008-06-11 |
| EP1554576B9 (de) | 2008-08-20 |
| EP1554576A4 (de) | 2006-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |