DE60330893D1 - Intrazelluläre antikörper - Google Patents

Intrazelluläre antikörper

Info

Publication number
DE60330893D1
DE60330893D1 DE60330893T DE60330893T DE60330893D1 DE 60330893 D1 DE60330893 D1 DE 60330893D1 DE 60330893 T DE60330893 T DE 60330893T DE 60330893 T DE60330893 T DE 60330893T DE 60330893 D1 DE60330893 D1 DE 60330893D1
Authority
DE
Germany
Prior art keywords
intracellular
molecule
immunoglobulin
target
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330893T
Other languages
English (en)
Inventor
Terence Howard Rabbitts
Tomoyuki Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council filed Critical Medical Research Council
Application granted granted Critical
Publication of DE60330893D1 publication Critical patent/DE60330893D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60330893T 2002-11-15 2003-11-14 Intrazelluläre antikörper Expired - Lifetime DE60330893D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0226729.2A GB0226729D0 (en) 2002-11-15 2002-11-15 Intracellular antibodies
PCT/GB2003/004942 WO2004046185A2 (en) 2002-11-15 2003-11-14 Intracellular antibodies

Publications (1)

Publication Number Publication Date
DE60330893D1 true DE60330893D1 (de) 2010-02-25

Family

ID=9947935

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330893T Expired - Lifetime DE60330893D1 (de) 2002-11-15 2003-11-14 Intrazelluläre antikörper

Country Status (10)

Country Link
US (2) US20050272107A1 (de)
EP (1) EP1560853B1 (de)
JP (1) JP2006518188A (de)
AT (1) ATE454404T1 (de)
AU (1) AU2003286241A1 (de)
CA (1) CA2506124A1 (de)
DE (1) DE60330893D1 (de)
ES (1) ES2337570T3 (de)
GB (1) GB0226729D0 (de)
WO (1) WO2004046185A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662554B2 (en) * 2002-10-09 2010-02-16 The Trustees Of Boston University Nucleic acid supported protein complementation
US20090220942A1 (en) * 2005-10-27 2009-09-03 Natalia Broude Activated split-polypeptides and methods for their production and use
JP2009513141A (ja) * 2005-10-27 2009-04-02 トラスティーズ オブ ボストン ユニバーシティ タンパク質相補によるリアルタイムインビボ核酸検出
MX2009004464A (es) * 2006-10-27 2009-11-02 Univ Boston Conjugados biomoleculares divididos, dirigidos para el tratamiento de enfermedades, malignidades y desordenes, y metodos para su produccion.
GB0911215D0 (en) 2009-06-29 2009-08-12 Univ Erasmus Medical Ct Gamma globin therapy
TWI450415B (zh) * 2010-03-23 2014-08-21 Lg Innotek Co Ltd 發光裝置、發光裝置封裝件及照明系統
GB201103631D0 (en) * 2011-03-03 2011-04-13 Univ Leeds Identification of candidate therapeutics
TWI640537B (zh) 2011-12-05 2018-11-11 Ｘ 染色體有限公司 ＰＤＧＦ受體β結合多肽
US10078085B2 (en) 2012-08-22 2018-09-18 Mogam Biothechnology Institute Screening and engineering method of super-stable immunoglobulin variable domains and their uses
EP2920319B1 (de) 2012-11-16 2020-02-19 Poseida Therapeutics, Inc. Ortsspezifische enzyme und verfahren zur verwendung
LT2981822T (lt) 2013-05-06 2020-12-28 Scholar Rock, Inc. Kompozicijos ir būdai, skirti augimo faktoriaus moduliacijai
AU2015277180A1 (en) * 2014-06-17 2017-01-12 Poseida Therapeutics, Inc. A method for directing proteins to specific loci in the genome and uses thereof
US20170267784A1 (en) 2014-10-23 2017-09-21 Singh Molecular Medicine, Llc Single domain antibodies directed against intracellular antigens
CA2962275C (en) 2014-10-23 2019-11-05 Singh Biotechnology, Llc Single domain antibodies directed against intracellular antigens
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
ES2941897T3 (es) 2014-11-12 2023-05-26 Seagen Inc Compuestos que interaccionan con glicanos y procedimientos de uso
EP3929286A1 (de) 2015-06-17 2021-12-29 Poseida Therapeutics, Inc. Zusammensetzungen und verfahren zur führung von proteinen an spezifische loci im genom
TWI746473B (zh) 2015-11-02 2021-11-21 美商辛分子醫藥有限公司 針對細胞內抗原之單域抗體
IL258768B2 (en) 2015-11-12 2023-11-01 Siamab Therapeutics Inc Compounds interacting with glycans and methods of use
JP6293829B2 (ja) * 2016-08-05 2018-03-14 モガム インスティチュート フォー バイオメディカル リサーチＭＯＧＡＭ Ｉｎｓｔｉｔｕｔｅ ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ 安定化された免疫グロブリン可変ドメイン選別方法及び選別されたドメインの応用
EP3541847A4 (de) 2016-11-17 2020-07-08 Seattle Genetics, Inc. Glycaninteragierende verbindungen und verfahren zur verwendung
KR20240044544A (ko) 2017-03-03 2024-04-04 씨젠 인크. 글리칸-상호작용 화합물 및 사용 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919650A (en) * 1990-04-22 1999-07-06 Bristol-Myers Squibb Co. Method for inactivation of protein function
JP4436457B2 (ja) * 1995-08-18 2010-03-24 モルフォシス アイピー ゲーエムベーハー 蛋白質／（ポリ）ペプチドライブラリー
GB2344886B (en) * 1999-03-10 2000-11-01 Medical Res Council Selection of intracellular immunoglobulins
AU2003219277A1 (en) * 2002-03-14 2003-09-29 Medical Research Council Intracellular antibodies
US6919650B2 (en) * 2002-05-31 2005-07-19 Ballard Power Systems Corporation Hybrid synchronization phase angle generation method

Also Published As

Publication number Publication date
WO2004046185A2 (en) 2004-06-03
CA2506124A1 (en) 2004-06-03
EP1560853B1 (de) 2010-01-06
US20100143939A1 (en) 2010-06-10
US20050272107A1 (en) 2005-12-08
ES2337570T3 (es) 2010-04-27
ATE454404T1 (de) 2010-01-15
WO2004046185A3 (en) 2004-09-23
AU2003286241A1 (en) 2004-06-15
EP1560853A2 (de) 2005-08-10
GB0226729D0 (en) 2002-12-24
JP2006518188A (ja) 2006-08-10

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Legal Events

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