MX2009004464A - Conjugados biomoleculares divididos, dirigidos para el tratamiento de enfermedades, malignidades y desordenes, y metodos para su produccion. - Google Patents

Conjugados biomoleculares divididos, dirigidos para el tratamiento de enfermedades, malignidades y desordenes, y metodos para su produccion.

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Publication number
MX2009004464A
MX2009004464A MX2009004464A MX2009004464A MX2009004464A MX 2009004464 A MX2009004464 A MX 2009004464A MX 2009004464 A MX2009004464 A MX 2009004464A MX 2009004464 A MX2009004464 A MX 2009004464A MX 2009004464 A MX2009004464 A MX 2009004464A
Authority
MX
Mexico
Prior art keywords
split
malignancies
disorders
diseases
treatment
Prior art date
Application number
MX2009004464A
Other languages
English (en)
Inventor
Vadim Demidov
Natalia Broude
Charles Cantor
William Evans
Original Assignee
Univ Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Boston filed Critical Univ Boston
Publication of MX2009004464A publication Critical patent/MX2009004464A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
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    • A61K49/0013—Luminescence
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Abstract

La presente invención se dirige a composiciones y métodos para la producción de conjugados biomoleculares divididos para el objetivo dirigido de ácidos nucleicos y polipéptidos. Más de preferencia, las composiciones y métodos permiten el uso de los conjugados biomoleculares divididos para el tratamiento de enfermedades, malignidades, desórdenes y la clasificación. En algunas modalidades, los conjugados biomoleculares divididos comprenden fragmentos de proteína efectora divididos, conjugados a una sonda, y la interacción de ambas sondas con un ácido nucleico objetivo o polipéptido objetivo, tal como una secuencia de acido nucleico patogénica o proteína patogénica, lleva a los fragmentos efectores divididos conjuntamente para facilitar el reensamble de la molécula efectora. Dependiendo de la molécula efectora, la complementación de proteína da por resultado un efecto celular, en particular para el tratamiento de enfermedades, malignidades y desórdenes.
MX2009004464A 2006-10-27 2007-10-26 Conjugados biomoleculares divididos, dirigidos para el tratamiento de enfermedades, malignidades y desordenes, y metodos para su produccion. MX2009004464A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85489206P 2006-10-27 2006-10-27
PCT/US2007/082665 WO2008133709A2 (en) 2006-10-27 2007-10-26 Targeted split biomolecular conjugates for the treatment of diseases, malignancies and disorders, and methods of their production

Publications (1)

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MX2009004464A true MX2009004464A (es) 2009-11-02

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MX2009004464A MX2009004464A (es) 2006-10-27 2007-10-26 Conjugados biomoleculares divididos, dirigidos para el tratamiento de enfermedades, malignidades y desordenes, y metodos para su produccion.

Country Status (12)

Country Link
US (1) US20100047179A1 (es)
EP (1) EP2097109A2 (es)
JP (1) JP2010509194A (es)
KR (1) KR20090073255A (es)
CN (1) CN101687047A (es)
AU (1) AU2007352344A1 (es)
CA (1) CA2667621A1 (es)
IL (1) IL198358A0 (es)
MX (1) MX2009004464A (es)
RU (1) RU2009120007A (es)
SG (1) SG177995A1 (es)
WO (1) WO2008133709A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033485A2 (en) 2002-10-09 2004-04-22 The Trustees Of Boston University Nucleic acid supported protein complementation
CA2627413A1 (en) * 2005-10-27 2007-05-03 The Trustees Of Boston University Activated split-polypeptides and methods for their production and use
RU2611186C2 (ru) * 2009-12-29 2017-02-21 Курна, Инк. ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С ОПУХОЛЕВЫМ БЕЛКОМ 63 (р63), ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К р63
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