ES2129454T3 - Procedimientos y composiciones de tratamientos de cancer y pronostico de reacciones a los indicados tratamientos. - Google Patents

Procedimientos y composiciones de tratamientos de cancer y pronostico de reacciones a los indicados tratamientos.

Info

Publication number
ES2129454T3
ES2129454T3 ES92918871T ES92918871T ES2129454T3 ES 2129454 T3 ES2129454 T3 ES 2129454T3 ES 92918871 T ES92918871 T ES 92918871T ES 92918871 T ES92918871 T ES 92918871T ES 2129454 T3 ES2129454 T3 ES 2129454T3
Authority
ES
Spain
Prior art keywords
treatments
cancer
forecast
reactions
procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92918871T
Other languages
English (en)
Inventor
Sarah S Bacus
Yosef Yarden
Michael Sela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Becton Dickinson and Co
Original Assignee
Yeda Research and Development Co Ltd
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL99284A external-priority patent/IL99284A0/xx
Application filed by Yeda Research and Development Co Ltd, Becton Dickinson and Co filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2129454T3 publication Critical patent/ES2129454T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE DESCRIBE UN METODO PARA DETERMINAR LA EFICACIA DE UN AGENTE TERAPEUTICO, IN VITRO, PARA QUE UN PRODUCTO ONCOGENO EXPRESE O SOBREEXPRESE UN CANCER. EL METODO ES PARTICULARMENTE UTIL PARA DETERMINAR LA EFICACIA DE AGENTES TERAPEUTICOS QUE TIENEN UNA AFINIDAD DE ENLACE PARA EL CANCER QUE EXPRESA HER-2/NEU. SE DESCRIBEN LOS ANTICUERPOS MONOCLONALES N24, N28 Y N29 QUE HAN SIDO IDENTIFICADOS POR ESTE METODO. UNO O MAS DE ESTOS ANTICUERPOS PUEDE SER USADO COMO AGENTE TERAPEUTICO EN EL TRATAMIENTO DE CANCERES DE PULMON, DE ESTOMAGO, DE OVARIOS O DE GLANDULAS SALIVALES.
ES92918871T 1991-08-22 1992-08-21 Procedimientos y composiciones de tratamientos de cancer y pronostico de reacciones a los indicados tratamientos. Expired - Lifetime ES2129454T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL99284A IL99284A0 (en) 1991-08-22 1991-08-22 Monoclonal antibodies to a growth factor receptor
US76704191A 1991-09-27 1991-09-27
US76704291A 1991-09-27 1991-09-27

Publications (1)

Publication Number Publication Date
ES2129454T3 true ES2129454T3 (es) 1999-06-16

Family

ID=27271513

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92918871T Expired - Lifetime ES2129454T3 (es) 1991-08-22 1992-08-21 Procedimientos y composiciones de tratamientos de cancer y pronostico de reacciones a los indicados tratamientos.

Country Status (8)

Country Link
US (1) US5514554A (es)
EP (2) EP0656367A1 (es)
AT (1) ATE176328T1 (es)
AU (2) AU663727B2 (es)
CA (1) CA2096417C (es)
DE (1) DE69228300T2 (es)
ES (1) ES2129454T3 (es)
WO (1) WO1993003741A1 (es)

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Also Published As

Publication number Publication date
AU1147595A (en) 1995-06-15
AU663727B2 (en) 1995-10-19
CA2096417A1 (en) 1993-02-23
DE69228300T2 (de) 1999-09-23
CA2096417C (en) 2000-10-10
DE69228300D1 (de) 1999-03-11
EP0554441A4 (en) 1994-07-27
EP0554441B1 (en) 1999-01-27
AU2518292A (en) 1993-03-16
WO1993003741A1 (en) 1993-03-04
US5514554A (en) 1996-05-07
EP0656367A1 (en) 1995-06-07
ATE176328T1 (de) 1999-02-15
EP0554441A1 (en) 1993-08-11

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