JP7319331B2 - オープンフィールドハンドヘルド蛍光イメージングシステムおよび方法 - Google Patents
オープンフィールドハンドヘルド蛍光イメージングシステムおよび方法 Download PDFInfo
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- H04N25/13—Arrangement of colour filter arrays [CFA]; Filter mosaics characterised by the spectral characteristics of the filter elements
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- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
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- G03B2215/00—Special procedures for taking photographs; Apparatus therefor
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- G03B2215/0589—Diffusors, filters or refraction means
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Description
本願は、「OPEN-FIELD HANDHELD FLUORESCENCE IMAGING SYSTEMS AND METHODS」というタイトルの2017年2月10日に提出された米国特許仮出願第62/457,690号の優先権の利益を享受する。その出願は、その全体が参照により本明細書に組み入れられる。
Exp1=2A+F
Exp2=A+F
Fについて解くと、
F=2*Exp2-Expl
例
イメージデータの取得のための蛍光医療イメージングシステム
・種々の処理動作を行うよう構成されたプロセッサモジュール(不図示)であって、処理動作がコンピュータ可読媒体に保持されるインストラクションを実行することを含み、インストラクションが本明細書で説明されたシステムのうちのひとつ以上に本明細書で説明された方法および技術を実行させる、プロセッサモジュール。
・動作からのデータを記録し保持するための、また、ある実施の形態ではプロセッサモジュールによって実行可能なインストラクションを保持するためのデータストレージモジュール(不図示)であって、該インストラクションは本明細書で開示された方法および技術を実装するためのものである、データストレージモジュール。
イメージデータを生成する際に用いられる例示的なイメージング剤
F=2*Exp2-Exp1
ここで、Exp1は蛍光露光時間の前記ある割合の間の信号出力であり、Exp2は前記蛍光露光時間全体の間の信号出力である。
Claims (26)
- イメージング視野を有するイメージングデバイスであって、
ターゲットを照らすための光を出力するよう構成された少なくともひとつの照明ポートと、
イメージングセンサであって、光路に沿って該イメージングセンサへと伝搬する光を検出するイメージングセンサと、
前記光路に沿った光の伝搬方向に関して前記イメージングセンサの上流に設けられた第1可動ウインドウであって、前記第1可動ウインドウが、前記ターゲットから受けた光を変更するために、配備された位置において、前記光路の中へと移動するよう構成される、前記第1可動ウインドウと、
前記光路に沿った光の前記伝搬方向に関して前記イメージングセンサの上流に設けられた第2可動ウインドウであって、前記第2可動ウインドウが、前記ターゲットから受けた光を変更するために、配備された位置において、前記光路の中へと移動するよう構成される、第2可動ウインドウと、を備え、
前記第1可動ウインドウが、光軸に対して垂直に延びる第1ピボット軸の周りでピボットするよう構成され、前記第2可動ウインドウが、前記光軸に対して垂直に延びる第2ピボット軸の周りでピボットするよう構成され、前記第1ピボット軸および第2ピボット軸が、前記光軸に対して垂直に広がる平面と同一平面内にある、イメージングデバイス。 - 前記第1可動ウインドウがフィルタを含む請求項1に記載のイメージングデバイス。
- 前記フィルタが可視光をフィルタリングするよう構成される請求項2に記載のイメージングデバイス。
- 前記第1可動ウインドウおよび前記第2可動ウインドウがリンケージに結合され、該リンケージが第1ピボットウインドウおよび第2ピボットウインドウを同時に動かすよう構成される請求項1から3のいずれか一項に記載のイメージングデバイス。
- 前記第1可動ウインドウが前記配備された位置にある場合、前記第2可動ウインドウが収納位置において前記光路から出るように動かされる請求項1から4のいずれか一項に記載のイメージングデバイス。
- 前記イメージングセンサが、前記第1可動ウインドウに対して変位可能である請求項1から5のいずれか一項に記載のイメージングデバイス。
- 前記第1可動ウインドウが、前記配備された位置において、光軸に対して垂直に広がり、前記イメージングセンサが、前記光軸に沿って変位可能である請求項6に記載のイメージングデバイス。
- 前記イメージングセンサは、前記ターゲットからの光であって可視光および励起光による照明により生じた光を検出するよう構成された単一のセンサである請求項1から7のいずれか一項に記載のイメージングデバイス。
- 前記イメージングセンサの上流に波長依存開口を備え、前記波長依存開口は中央領域の外側の可視光を遮るよう構成される請求項8に記載のイメージングデバイス。
- 前記イメージングデバイスに入射する光の量を検出するためのひとつ以上のセンサを備える請求項1から9のいずれか一項に記載のイメージングデバイス。
- 前記ひとつ以上のセンサからの出力に基づいて、少なくともひとつのイメージ取得パラメータを調整するよう構成された制御システムを備える請求項10に記載のイメージングデバイス。
- 前記少なくともひとつのイメージ取得パラメータが、露光期間、励起照明期間、励起照明パワー、またはイメージングセンサ利得を含む請求項11に記載のイメージングデバイス。
- 前記ひとつ以上のセンサのうちの少なくともひとつは、可視光および近赤外光を検出するよう構成される請求項10から12のいずれか一項に記載のイメージングデバイス。
- 前記ひとつ以上のセンサのうちの少なくともひとつは、近赤外光を検出するよう構成される請求項10から13のいずれか一項に記載のイメージングデバイス。
- ターゲットをイメージングする方法であって、
イメージングデバイスの照明器で前記ターゲットを照らすことと、
第1イメージングモードにおいて、前記イメージングデバイスのイメージングセンサで前記ターゲットからの光を受けることであって、前記第1イメージングモードにおいて前記イメージングセンサで受けた前記光のうちの少なくともいくらかが第1帯域内の波長を含む、ことと、
第2イメージングモードに切り替えることと、
前記第2イメージングモードにある間に、
前記ターゲットから前記イメージングセンサへ伝搬する光が沿う光路の中へ第1可動フィルタを移動し、前記光路の外へ第2可動フィルタを移動することであって、前記第1可動フィルタが、光軸に対して垂直に延びる第1ピボット軸の周りでピボットするよう構成され、前記第2可動フィルタが、前記光軸に対して垂直に延びる第2ピボット軸の周りでピボットするよう構成され、前記第1ピボット軸および第2ピボット軸が、前記光軸に対して垂直に広がる平面と同一平面内にある、ことと、
前記イメージングデバイスの前記第1可動フィルタを用いて、前記ターゲットから受けた光のうち第2帯域の外側の波長の光が、前記イメージングセンサに到達することを阻止することであって、前記阻止される光のうちの少なくともいくらかが前記第1帯域内の波長を含む、ことと、
前記イメージングセンサにおいて、前記ターゲットから受けた光のうち前記第2帯域内の波長の光を受けることと、を含む方法。 - 前記第2帯域が近赤外波長を含む請求項15に記載の方法。
- 前記第1帯域が可視光波長を含む請求項15または16に記載の方法。
- 前記第2イメージングモードにある間に、前記イメージングデバイスのひとつ以上の光レベルセンサにおいて光レベルを検出することと、前記ひとつ以上の光レベルセンサの出力に基づいて、イメージセンサ信号利得、照明パルス継続期間、イメージセンサ露光、および照明パワーのうちのひとつ以上を調整することと、を含む請求項15から17のいずれか一項に記載の方法。
- 前記第1イメージングモードにある間に、前記イメージングデバイスのひとつ以上の光レベルセンサにおいて光レベルを検出することと、前記ひとつ以上の光レベルセンサの出力に基づいて、イメージセンサ信号利得、照明パルス継続期間、イメージセンサ露光、および照明パワーのうちのひとつ以上を調整することと、を含む請求項18に記載の方法。
- 前記第2イメージングモードに切り替えることが、前記第1可動フィルタを光路の中へと動かすことを含み、前記ターゲットからの光が当該光路に沿って前記イメージングセンサへと伝搬する請求項15から19のいずれか一項に記載の方法。
- 前記第2イメージングモードに切り替えることが、クリアウインドウを前記光路から出るように動かすことを含む請求項20に記載の方法。
- 前記第1イメージングモードが、ユーザ要求に応じて前記第2イメージングモードに切り替えられる請求項15から21のいずれか一項に記載の方法。
- 前記ユーザ要求が前記イメージングデバイスに対するユーザ入力を含む請求項22に記載の方法。
- 前記第2イメージングモードにある間に、ユーザから、前記第1イメージングモードに切り替えることを求める要求を受けることと、
前記ユーザから前記第1イメージングモードに切り替えることを求める前記要求を受けることに応じて、可動フィルタを光路から出るように動かすことと、を含む請求項15から23のいずれか一項に記載の方法。 - 前記第2イメージングモードにある間に、前記イメージングデバイスのひとつ以上の光レベルセンサにおいて光レベルを検出すること、および前記ひとつ以上の光レベルセンサの出力に基づいて、イメージセンサ信号利得、照明パルス継続期間、イメージセンサ露光、および照明パワーのうちのひとつ以上を調整することと、
前記ユーザから前記第1イメージングモードに切り替えることを求める前記要求を受けることに応じて、前記ひとつ以上の光レベルセンサの出力に基づいた、イメージセンサ信号利得、照明パルス継続期間、イメージセンサ露光、および照明パワーのうちのひとつ以上の調整を止めることと、を含む請求項24に記載の方法。 - 前記照明器の照明ビームを少なくとも部分的に阻止するオブジェクトを検出することと、前記オブジェクトの検出に応じて、前記照明器の照明パワーを調整することと、を含む請求項15から25のいずれか一項に記載の方法。
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JP2023118437A JP2023153861A (ja) | 2017-02-10 | 2023-07-20 | オープンフィールドハンドヘルド蛍光イメージングシステムおよび方法 |
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