MX9801351A - Formacion de imagenes y espectroscopia en base a la duracion de vida de la fluorescencia en tejidos y otros medios aleatorios. - Google Patents

Formacion de imagenes y espectroscopia en base a la duracion de vida de la fluorescencia en tejidos y otros medios aleatorios.

Info

Publication number
MX9801351A
MX9801351A MX9801351A MX9801351A MX9801351A MX 9801351 A MX9801351 A MX 9801351A MX 9801351 A MX9801351 A MX 9801351A MX 9801351 A MX9801351 A MX 9801351A MX 9801351 A MX9801351 A MX 9801351A
Authority
MX
Mexico
Prior art keywords
tissue
excitation
light
processor
spatial variation
Prior art date
Application number
MX9801351A
Other languages
English (en)
Inventor
Eva M Sevick-Muraca
Dilip Y Paithankar
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of MX9801351A publication Critical patent/MX9801351A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

Se describe un sistema y método de formacion de imágenes opticas, biomédica, no invasiva y espectroscopia con bajo nivel de luz. La técnica consiste de una fuente de luz modulada (120) acoplada al tejido (100) de un paciente para introducir la luz de excitacion. La luz fluorescente emitida en respuesta a la luz de excitacion se detecta con el sensor (148). La intensidad de AC y la fase de la luz de excitacion y fluorescente detectada se proporciona para un procesador (160) acoplado de manera operativa al sensor (148). El procesador (160) emplea las cinética de re-emision, medida de la luz de excitacion y fluorescente para "trazar un mapa" de la variacion espacial de una o más características de fluorescencia del tejido (100). La característica de fluorescencia se puede proporcionar por agentes de contraste exogenos, fluoroforos endogenos, o ambos. Las variaciones se determinan al resolver las ecuaciones de difusion de recinto de frecuencia en un numero de puntos designados en el tejido como parte de un algoritmo de estimacion repetitivo. El procesador (160) genera una señal de formacion de imágenes de acuerdo con la variacion espacial de la característica de fluorescencia para proporcionar a un dispositivo de salida (164). El dispositivo de salida (164) visualiza una imagen que corresponde a la variacion espacial de la característica de fluorescencia que corresponde al tejido (100) para ayudar en la deteccion y diagnosis de enfermedades.
MX9801351A 1995-08-24 1996-08-23 Formacion de imagenes y espectroscopia en base a la duracion de vida de la fluorescencia en tejidos y otros medios aleatorios. MX9801351A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US274695P 1995-08-24 1995-08-24
PCT/US1996/013658 WO1997008538A1 (en) 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media

Publications (1)

Publication Number Publication Date
MX9801351A true MX9801351A (es) 1998-07-31

Family

ID=21702295

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9801351A MX9801351A (es) 1995-08-24 1996-08-23 Formacion de imagenes y espectroscopia en base a la duracion de vida de la fluorescencia en tejidos y otros medios aleatorios.

Country Status (9)

Country Link
US (1) US5865754A (es)
EP (1) EP0846262A4 (es)
JP (1) JP3819032B2 (es)
CN (1) CN1200174A (es)
AU (1) AU1130797A (es)
CA (1) CA2230228C (es)
MX (1) MX9801351A (es)
NO (1) NO980750L (es)
WO (1) WO1997008538A1 (es)

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