JP2020516653A - プルランカプセル - Google Patents
プルランカプセル Download PDFInfo
- Publication number
- JP2020516653A JP2020516653A JP2019555931A JP2019555931A JP2020516653A JP 2020516653 A JP2020516653 A JP 2020516653A JP 2019555931 A JP2019555931 A JP 2019555931A JP 2019555931 A JP2019555931 A JP 2019555931A JP 2020516653 A JP2020516653 A JP 2020516653A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- capsule
- lecithin
- weight
- capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 115
- 239000004373 Pullulan Substances 0.000 title claims abstract description 54
- 229920001218 Pullulan Polymers 0.000 title claims abstract description 54
- 235000019423 pullulan Nutrition 0.000 title claims abstract description 54
- -1 fatty acid ester Chemical class 0.000 claims abstract description 60
- 235000010964 sucroglyceride Nutrition 0.000 claims abstract description 42
- 239000001957 sucroglyceride Substances 0.000 claims abstract description 42
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 39
- 239000000194 fatty acid Substances 0.000 claims abstract description 39
- 229930195729 fatty acid Natural products 0.000 claims abstract description 39
- 235000000346 sugar Nutrition 0.000 claims abstract description 30
- 239000004094 surface-active agent Substances 0.000 claims abstract description 30
- 230000015271 coagulation Effects 0.000 claims abstract description 28
- 238000005345 coagulation Methods 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 21
- 239000007963 capsule composition Substances 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims description 79
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 44
- 235000010445 lecithin Nutrition 0.000 claims description 44
- 239000000787 lecithin Substances 0.000 claims description 44
- 229940067606 lecithin Drugs 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 229930006000 Sucrose Natural products 0.000 claims description 24
- 239000005720 sucrose Substances 0.000 claims description 24
- 239000007787 solid Substances 0.000 claims description 20
- 229940005741 sunflower lecithin Drugs 0.000 claims description 20
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 19
- 239000008158 vegetable oil Substances 0.000 claims description 19
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 18
- 238000007598 dipping method Methods 0.000 claims description 17
- 238000000576 coating method Methods 0.000 claims description 16
- 235000019482 Palm oil Nutrition 0.000 claims description 15
- 239000011248 coating agent Substances 0.000 claims description 15
- 235000019864 coconut oil Nutrition 0.000 claims description 15
- 239000003240 coconut oil Substances 0.000 claims description 15
- 239000002540 palm oil Substances 0.000 claims description 15
- 239000000314 lubricant Substances 0.000 claims description 13
- 235000012343 cottonseed oil Nutrition 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 229940071160 cocoate Drugs 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 9
- 239000003346 palm kernel oil Substances 0.000 claims description 9
- 235000019865 palm kernel oil Nutrition 0.000 claims description 9
- 235000017060 Arachis glabrata Nutrition 0.000 claims description 8
- 244000105624 Arachis hypogaea Species 0.000 claims description 8
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 8
- 235000018262 Arachis monticola Nutrition 0.000 claims description 8
- 235000005687 corn oil Nutrition 0.000 claims description 8
- 239000002285 corn oil Substances 0.000 claims description 8
- 239000002385 cottonseed oil Substances 0.000 claims description 8
- 238000007654 immersion Methods 0.000 claims description 8
- 235000020232 peanut Nutrition 0.000 claims description 8
- 235000019483 Peanut oil Nutrition 0.000 claims description 7
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 7
- 235000019486 Sunflower oil Nutrition 0.000 claims description 7
- 235000019519 canola oil Nutrition 0.000 claims description 7
- 239000000828 canola oil Substances 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 7
- 235000019438 castor oil Nutrition 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
- 235000021388 linseed oil Nutrition 0.000 claims description 7
- 239000000944 linseed oil Substances 0.000 claims description 7
- 235000008390 olive oil Nutrition 0.000 claims description 7
- 239000004006 olive oil Substances 0.000 claims description 7
- 239000000312 peanut oil Substances 0.000 claims description 7
- 239000003352 sequestering agent Substances 0.000 claims description 7
- 235000011803 sesame oil Nutrition 0.000 claims description 7
- 239000008159 sesame oil Substances 0.000 claims description 7
- 235000012424 soybean oil Nutrition 0.000 claims description 7
- 239000003549 soybean oil Substances 0.000 claims description 7
- 239000002600 sunflower oil Substances 0.000 claims description 7
- 238000000855 fermentation Methods 0.000 claims description 6
- 230000004151 fermentation Effects 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- 235000005713 safflower oil Nutrition 0.000 claims description 6
- 239000003813 safflower oil Substances 0.000 claims description 6
- 235000019485 Safflower oil Nutrition 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- 239000003086 colorant Substances 0.000 claims description 5
- 239000004014 plasticizer Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 240000008042 Zea mays Species 0.000 claims description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 235000005822 corn Nutrition 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 3
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 3
- 229930182830 galactose Natural products 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims description 3
- 239000007894 caplet Substances 0.000 claims description 2
- 125000000185 sucrose group Chemical group 0.000 claims description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims 1
- 244000020518 Carthamus tinctorius Species 0.000 claims 1
- 229940083466 soybean lecithin Drugs 0.000 claims 1
- 150000001768 cations Chemical class 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 239000011777 magnesium Substances 0.000 description 12
- 239000011575 calcium Substances 0.000 description 10
- 235000002639 sodium chloride Nutrition 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000000049 pigment Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 7
- 241000186660 Lactobacillus Species 0.000 description 7
- 150000004676 glycans Chemical class 0.000 description 7
- 229940039696 lactobacillus Drugs 0.000 description 7
- 229920001282 polysaccharide Polymers 0.000 description 7
- 239000005017 polysaccharide Substances 0.000 description 7
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 229920002148 Gellan gum Polymers 0.000 description 6
- 229960002568 ethinylestradiol Drugs 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000000155 melt Substances 0.000 description 6
- 238000000465 moulding Methods 0.000 description 6
- 235000010418 carrageenan Nutrition 0.000 description 5
- 229920001525 carrageenan Polymers 0.000 description 5
- 239000000679 carrageenan Substances 0.000 description 5
- 229940113118 carrageenan Drugs 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000262 estrogen Substances 0.000 description 5
- 229940011871 estrogen Drugs 0.000 description 5
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 5
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 5
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 4
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 4
- 229960001484 edetic acid Drugs 0.000 description 4
- CHNXZKVNWQUJIB-CEGNMAFCSA-N ethisterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 CHNXZKVNWQUJIB-CEGNMAFCSA-N 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 229920000591 gum Polymers 0.000 description 4
- 239000007902 hard capsule Substances 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 239000000416 hydrocolloid Substances 0.000 description 4
- 229960004400 levonorgestrel Drugs 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 235000010215 titanium dioxide Nutrition 0.000 description 4
- 239000004408 titanium dioxide Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 4
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 3
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 239000002028 Biomass Substances 0.000 description 3
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 3
- 229960000445 ethisterone Drugs 0.000 description 3
- 230000001632 homeopathic effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000013980 iron oxide Nutrition 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000000583 progesterone congener Substances 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000008347 soybean phospholipid Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 2
- XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 description 2
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- NMKSAYKQLCHXDK-UHFFFAOYSA-N 3,3-diphenyl-N-(1-phenylethyl)-1-propanamine Chemical compound C=1C=CC=CC=1C(C)NCCC(C=1C=CC=CC=1)C1=CC=CC=C1 NMKSAYKQLCHXDK-UHFFFAOYSA-N 0.000 description 2
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 240000002791 Brassica napus Species 0.000 description 2
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 2
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229920002752 Konjac Polymers 0.000 description 2
- 229920000161 Locust bean gum Polymers 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 229920000057 Mannan Polymers 0.000 description 2
- 235000021360 Myristic acid Nutrition 0.000 description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 241000235070 Saccharomyces Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229960001616 chlormadinone acetate Drugs 0.000 description 2
- DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 description 2
- 229960000876 cinnarizine Drugs 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- VQKLRVZQQYVIJW-UHFFFAOYSA-N dihydralazine Chemical compound C1=CC=C2C(NN)=NN=C(NN)C2=C1 VQKLRVZQQYVIJW-UHFFFAOYSA-N 0.000 description 2
- 229960002877 dihydralazine Drugs 0.000 description 2
- 229910001882 dioxygen Inorganic materials 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229930182833 estradiol Natural products 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 229960001348 estriol Drugs 0.000 description 2
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 description 2
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 229960002602 fendiline Drugs 0.000 description 2
- 238000000705 flame atomic absorption spectrometry Methods 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000010492 gellan gum Nutrition 0.000 description 2
- 239000000216 gellan gum Substances 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 229960002899 hydroxyprogesterone Drugs 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 2
- 229960000991 ketoprofen Drugs 0.000 description 2
- 235000010485 konjac Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000010420 locust bean gum Nutrition 0.000 description 2
- 239000000711 locust bean gum Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 2
- 229960002985 medroxyprogesterone acetate Drugs 0.000 description 2
- 229960001962 mefloquine Drugs 0.000 description 2
- 229960004296 megestrol acetate Drugs 0.000 description 2
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 2
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 2
- 229960004963 mesalazine Drugs 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- XNEFVTBPCXGIRX-UHFFFAOYSA-N methanesulfinic acid Chemical compound CS(O)=O XNEFVTBPCXGIRX-UHFFFAOYSA-N 0.000 description 2
- 229960001652 norethindrone acetate Drugs 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 239000002151 riboflavin Substances 0.000 description 2
- 235000019192 riboflavin Nutrition 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 150000003445 sucroses Chemical class 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 229960001603 tamoxifen Drugs 0.000 description 2
- 229960000195 terbutaline Drugs 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 229910001773 titanium mineral Inorganic materials 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- VLPIATFUUWWMKC-SNVBAGLBSA-N (2r)-1-(2,6-dimethylphenoxy)propan-2-amine Chemical compound C[C@@H](N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-SNVBAGLBSA-N 0.000 description 1
- WDQLRUYAYXDIFW-RWKIJVEZSA-N (2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 WDQLRUYAYXDIFW-RWKIJVEZSA-N 0.000 description 1
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 1
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
- ISHXLNHNDMZNMC-VTKCIJPMSA-N (3e,8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C\1 ISHXLNHNDMZNMC-VTKCIJPMSA-N 0.000 description 1
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
- VVFNKRFSOQCQJP-DDDPLHQBSA-N (8s,9s,10r,13s,14s,17s)-17-acetyl-1,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1C[C@@H]2[C@@]3(C)C(C)CC(=O)C=C3CC[C@H]2[C@@H]2CC[C@H](C(C)=O)[C@]21C VVFNKRFSOQCQJP-DDDPLHQBSA-N 0.000 description 1
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 1
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 description 1
- BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 description 1
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- PVHUJELLJLJGLN-INIZCTEOSA-N (S)-nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-INIZCTEOSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- JKKFKPJIXZFSSB-UHFFFAOYSA-N 1,3,5(10)-estratrien-17-one 3-sulfate Natural products OS(=O)(=O)OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 JKKFKPJIXZFSSB-UHFFFAOYSA-N 0.000 description 1
- YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 description 1
- DKMFBWQBDIGMHM-UHFFFAOYSA-N 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone Chemical compound C1CC(C)CCN1CCCC(=O)C1=CC=C(F)C=C1 DKMFBWQBDIGMHM-UHFFFAOYSA-N 0.000 description 1
- GAIHSQSRHYQICG-DACBVQKSSA-N 1-[(6s,8r,9s,10r,13s,14s,17r)-17-hydroxy-6,10,13-trimethyl-1,2,3,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C([C@@]12C)CCC=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 GAIHSQSRHYQICG-DACBVQKSSA-N 0.000 description 1
- ZKFNOUUKULVDOB-UHFFFAOYSA-N 1-amino-1-phenylmethyl phosphonic acid Chemical compound OP(=O)(O)C(N)C1=CC=CC=C1 ZKFNOUUKULVDOB-UHFFFAOYSA-N 0.000 description 1
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-UHFFFAOYSA-N 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2C3CCC(C)(C(CC4)O)C4C3CCC2=C1 VOXZDWNPVJITMN-UHFFFAOYSA-N 0.000 description 1
- VTHUYJIXSMGYOQ-KOORYGTMSA-N 17-hydroxyprogesterone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 VTHUYJIXSMGYOQ-KOORYGTMSA-N 0.000 description 1
- VOXZDWNPVJITMN-SFFUCWETSA-N 17α-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-SFFUCWETSA-N 0.000 description 1
- NVUUMOOKVFONOM-GPBSYSOESA-N 19-Norprogesterone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 NVUUMOOKVFONOM-GPBSYSOESA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 2,3-dimethylbutane Chemical group CC(C)C(C)C ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 0.000 description 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- HPMZBILYSWLILX-UMDUKNJSSA-N 3'''-O-acetyldigitoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HPMZBILYSWLILX-UMDUKNJSSA-N 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- SQVIAVUSQAWMKL-UHFFFAOYSA-N 3-[2-(ethylamino)-1-hydroxyethyl]phenol Chemical compound CCNCC(O)C1=CC=CC(O)=C1 SQVIAVUSQAWMKL-UHFFFAOYSA-N 0.000 description 1
- KDPQTPZDVJHMET-UHFFFAOYSA-N 3-acetoxy-1,3,5(10)-estratrien-17-one Natural products C1CC2(C)C(=O)CCC2C2CCC3=CC(OC(=O)C)=CC=C3C21 KDPQTPZDVJHMET-UHFFFAOYSA-N 0.000 description 1
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 1
- QPGGEKPRGVJKQB-UHFFFAOYSA-N 5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone Chemical compound O=C1N(CCN(C)C)C2=CC=CC=C2N(C)C2=CC=CC=C21 QPGGEKPRGVJKQB-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- GEPMAHVDJHFBJI-UHFFFAOYSA-N 7-[2-hydroxy-3-[2-hydroxyethyl(methyl)amino]propyl]-1,3-dimethylpurine-2,6-dione;pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC=CN=C1.CN1C(=O)N(C)C(=O)C2=C1N=CN2CC(O)CN(CCO)C GEPMAHVDJHFBJI-UHFFFAOYSA-N 0.000 description 1
- XBWAZCLHZCFCGK-UHFFFAOYSA-N 7-chloro-1-methyl-5-phenyl-3,4-dihydro-2h-1,4-benzodiazepin-1-ium;chloride Chemical compound [Cl-].C12=CC(Cl)=CC=C2[NH+](C)CCN=C1C1=CC=CC=C1 XBWAZCLHZCFCGK-UHFFFAOYSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- HPMZBILYSWLILX-UHFFFAOYSA-N Acetyl-digitoxine Natural products C1C(OC(C)=O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O HPMZBILYSWLILX-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- ATXHVCQZZJYMCF-XUDSTZEESA-N Allylestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)CC=C)[C@@H]4[C@@H]3CCC2=C1 ATXHVCQZZJYMCF-XUDSTZEESA-N 0.000 description 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
- 241000223678 Aureobasidium pullulans Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 description 1
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 description 1
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- VMIYHDSEFNYJSL-UHFFFAOYSA-N Bromazepam Chemical compound C12=CC(Br)=CC=C2NC(=O)CN=C1C1=CC=CC=N1 VMIYHDSEFNYJSL-UHFFFAOYSA-N 0.000 description 1
- 108010004032 Bromelains Proteins 0.000 description 1
- RTMBGDBBDQKNNZ-UHFFFAOYSA-L C.I. Acid Blue 3 Chemical compound [Ca+2].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1.C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 RTMBGDBBDQKNNZ-UHFFFAOYSA-L 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 240000008886 Ceratonia siliqua Species 0.000 description 1
- 235000013912 Ceratonia siliqua Nutrition 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- PCLITLDOTJTVDJ-UHFFFAOYSA-N Chlormethiazole Chemical compound CC=1N=CSC=1CCCl PCLITLDOTJTVDJ-UHFFFAOYSA-N 0.000 description 1
- 229920001268 Cholestyramine Polymers 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 244000008991 Curcuma longa Species 0.000 description 1
- 229920002558 Curdlan Polymers 0.000 description 1
- 239000001879 Curdlan Substances 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 1
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 1
- RDOFJDLLWVCMRU-UHFFFAOYSA-N Diisobutyl adipate Chemical compound CC(C)COC(=O)CCCCC(=O)OCC(C)C RDOFJDLLWVCMRU-UHFFFAOYSA-N 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 108010061435 Enalapril Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 description 1
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 241000239366 Euphausiacea Species 0.000 description 1
- 239000004605 External Lubricant Substances 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- DJBNUMBKLMJRSA-UHFFFAOYSA-N Flecainide Chemical compound FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(C(=O)NCC2NCCCC2)=C1 DJBNUMBKLMJRSA-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920000926 Galactomannan Polymers 0.000 description 1
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 description 1
- 102400000932 Gonadoliberin-1 Human genes 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 101500026183 Homo sapiens Gonadoliberin-1 Proteins 0.000 description 1
- DOMWKUIIPQCAJU-LJHIYBGHSA-N Hydroxyprogesterone caproate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 DOMWKUIIPQCAJU-LJHIYBGHSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
- UEQUQVLFIPOEMF-UHFFFAOYSA-N Mianserin Chemical compound C1C2=CC=CC=C2N2CCN(C)CC2C2=CC=CC=C21 UEQUQVLFIPOEMF-UHFFFAOYSA-N 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 description 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
- FSVCELGFZIQNCK-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)glycine Chemical compound OCCN(CCO)CC(O)=O FSVCELGFZIQNCK-UHFFFAOYSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 229930182559 Natural dye Natural products 0.000 description 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- ICTXHFFSOAJUMG-SLHNCBLASA-N Norethynodrel Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C#C)[C@@H]3[C@@H]1CC2 ICTXHFFSOAJUMG-SLHNCBLASA-N 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- UJEWTUDSLQGTOA-UHFFFAOYSA-N Piretanide Chemical compound C=1C=CC=CC=1OC=1C(S(=O)(=O)N)=CC(C(O)=O)=CC=1N1CCCC1 UJEWTUDSLQGTOA-UHFFFAOYSA-N 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
- PPTYJKAXVCCBDU-UHFFFAOYSA-N Rohypnol Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1F PPTYJKAXVCCBDU-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002305 Schizophyllan Polymers 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- NHUHCSRWZMLRLA-UHFFFAOYSA-N Sulfisoxazole Chemical compound CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C NHUHCSRWZMLRLA-UHFFFAOYSA-N 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 240000004584 Tamarindus indica Species 0.000 description 1
- 235000004298 Tamarindus indica Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 229940123464 Thiazolidinedione Drugs 0.000 description 1
- 102000002933 Thioredoxin Human genes 0.000 description 1
- JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 description 1
- 244000111306 Torreya nucifera Species 0.000 description 1
- 235000006732 Torreya nucifera Nutrition 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229920002310 Welan gum Polymers 0.000 description 1
- 239000004234 Yellow 2G Substances 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 description 1
- ZPVGIKNDGJGLCO-VGAMQAOUSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZPVGIKNDGJGLCO-VGAMQAOUSA-N 0.000 description 1
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 1
- UEYVMVXJVDAGBB-ZHBLIPIOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl tetradecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O UEYVMVXJVDAGBB-ZHBLIPIOSA-N 0.000 description 1
- KDPQTPZDVJHMET-XSYGEPLQSA-N [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] acetate Chemical compound C1C[C@]2(C)C(=O)CC[C@H]2[C@@H]2CCC3=CC(OC(=O)C)=CC=C3[C@H]21 KDPQTPZDVJHMET-XSYGEPLQSA-N 0.000 description 1
- VQHQLBARMFAKSV-AANPDWTMSA-N [(8r,9s,13s,14s,17s)-3-acetyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(OC(C)=O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)C)[C@@]1(C)CC2 VQHQLBARMFAKSV-AANPDWTMSA-N 0.000 description 1
- YYFQNZXJGOTFRX-VMBLQBCYSA-N [(8r,9s,13s,14s,17s)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] decanoate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC2 YYFQNZXJGOTFRX-VMBLQBCYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 229960002122 acebutolol Drugs 0.000 description 1
- GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 description 1
- FSQKKOOTNAMONP-UHFFFAOYSA-N acemetacin Chemical compound CC1=C(CC(=O)OCC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 FSQKKOOTNAMONP-UHFFFAOYSA-N 0.000 description 1
- 229960004892 acemetacin Drugs 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- 229960003635 acetyldigitoxin Drugs 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 1
- 229960003459 allopurinol Drugs 0.000 description 1
- 229960002692 allylestrenol Drugs 0.000 description 1
- 239000002160 alpha blocker Substances 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 1
- DCAYPVUWAIABOU-UHFFFAOYSA-N alpha-n-hexadecene Natural products CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 229960005174 ambroxol Drugs 0.000 description 1
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 229960000836 amitriptyline Drugs 0.000 description 1
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 229950008564 anagestone Drugs 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 229940125364 angiotensin receptor blocker Drugs 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- PHFDAOXXIZOUIX-UHFFFAOYSA-N anipamil Chemical compound C=1C=CC(OC)=CC=1C(CCCCCCCCCCCC)(C#N)CCCN(C)CCC1=CC=CC(OC)=C1 PHFDAOXXIZOUIX-UHFFFAOYSA-N 0.000 description 1
- 229950011530 anipamil Drugs 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000000398 anti-amebic effect Effects 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 239000004004 anti-anginal agent Substances 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000000151 anti-reflux effect Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 229940125708 antidiabetic agent Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 229940125714 antidiarrheal agent Drugs 0.000 description 1
- 239000003793 antidiarrheal agent Substances 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 239000003904 antiprotozoal agent Substances 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 239000003420 antiserotonin agent Substances 0.000 description 1
- 229940124575 antispasmodic agent Drugs 0.000 description 1
- 239000003200 antithyroid agent Substances 0.000 description 1
- 229940043671 antithyroid preparations Drugs 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical class C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 1
- 229960005261 aspartic acid Drugs 0.000 description 1
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000000987 azo dye Substances 0.000 description 1
- WXLFIFHRGFOVCD-UHFFFAOYSA-L azophloxine Chemical compound [Na+].[Na+].OC1=C2C(NC(=O)C)=CC(S([O-])(=O)=O)=CC2=CC(S([O-])(=O)=O)=C1N=NC1=CC=CC=C1 WXLFIFHRGFOVCD-UHFFFAOYSA-L 0.000 description 1
- 235000012733 azorubine Nutrition 0.000 description 1
- TVWOWDDBXAFQDG-DQRAZIAOSA-N azorubine Chemical compound C1=CC=C2C(\N=N/C3=C(C4=CC=CC=C4C(=C3)S(O)(=O)=O)O)=CC=C(S(O)(=O)=O)C2=C1 TVWOWDDBXAFQDG-DQRAZIAOSA-N 0.000 description 1
- 229960000794 baclofen Drugs 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 235000012677 beetroot red Nutrition 0.000 description 1
- 239000001654 beetroot red Substances 0.000 description 1
- 229940116224 behenate Drugs 0.000 description 1
- UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 description 1
- FYJJXENSONZJRG-UHFFFAOYSA-N bencyclane Chemical compound C=1C=CC=CC=1CC1(OCCCN(C)C)CCCCCC1 FYJJXENSONZJRG-UHFFFAOYSA-N 0.000 description 1
- 229960000945 bencyclane Drugs 0.000 description 1
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 description 1
- 229960000911 benserazide Drugs 0.000 description 1
- 229940050390 benzoate Drugs 0.000 description 1
- 229960005274 benzocaine Drugs 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 229960004536 betahistine Drugs 0.000 description 1
- UUQMNUMQCIQDMZ-UHFFFAOYSA-N betahistine Chemical compound CNCCC1=CC=CC=N1 UUQMNUMQCIQDMZ-UHFFFAOYSA-N 0.000 description 1
- 229960002537 betamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
- 235000002185 betanin Nutrition 0.000 description 1
- 229960000516 bezafibrate Drugs 0.000 description 1
- IIBYAHWJQTYFKB-UHFFFAOYSA-N bezafibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1CCNC(=O)C1=CC=C(Cl)C=C1 IIBYAHWJQTYFKB-UHFFFAOYSA-N 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- YSXKPIUOCJLQIE-UHFFFAOYSA-N biperiden Chemical compound C1C(C=C2)CC2C1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 YSXKPIUOCJLQIE-UHFFFAOYSA-N 0.000 description 1
- 229960003003 biperiden Drugs 0.000 description 1
- 229960000503 bisacodyl Drugs 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 229960002729 bromazepam Drugs 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 description 1
- 229960003870 bromhexine Drugs 0.000 description 1
- 229960002802 bromocriptine Drugs 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 229960005438 calcium dobesilate Drugs 0.000 description 1
- QGNBTYAQAPLTMX-UHFFFAOYSA-L calcium dobesilate Chemical compound [Ca+2].OC1=CC=C(O)C(S([O-])(=O)=O)=C1.OC1=CC=C(O)C(S([O-])(=O)=O)=C1 QGNBTYAQAPLTMX-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000012682 canthaxanthin Nutrition 0.000 description 1
- 239000001659 canthaxanthin Substances 0.000 description 1
- 229940008033 canthaxanthin Drugs 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 235000019241 carbon black Nutrition 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- DGQLVPJVXFOQEV-JNVSTXMASA-N carminic acid Chemical compound OC1=C2C(=O)C=3C(C)=C(C(O)=O)C(O)=CC=3C(=O)C2=C(O)C(O)=C1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DGQLVPJVXFOQEV-JNVSTXMASA-N 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- LWAFSWPYPHEXKX-UHFFFAOYSA-N carteolol Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C LWAFSWPYPHEXKX-UHFFFAOYSA-N 0.000 description 1
- 229960001222 carteolol Drugs 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229960005361 cefaclor Drugs 0.000 description 1
- QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- CEZCCHQBSQPRMU-UHFFFAOYSA-L chembl174821 Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-UHFFFAOYSA-L 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229960004782 chlordiazepoxide Drugs 0.000 description 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
- 229960003996 chlormadinone Drugs 0.000 description 1
- 229940099898 chlorophyllin Drugs 0.000 description 1
- 235000019805 chlorophyllin Nutrition 0.000 description 1
- 229960002155 chlorothiazide Drugs 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- NJMYODHXAKYRHW-DVZOWYKESA-N cis-flupenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C2/1 NJMYODHXAKYRHW-DVZOWYKESA-N 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 229960002881 clemastine Drugs 0.000 description 1
- YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 description 1
- 229960001403 clobazam Drugs 0.000 description 1
- CXOXHMZGEKVPMT-UHFFFAOYSA-N clobazam Chemical compound O=C1CC(=O)N(C)C2=CC=C(Cl)C=C2N1C1=CC=CC=C1 CXOXHMZGEKVPMT-UHFFFAOYSA-N 0.000 description 1
- 229960001214 clofibrate Drugs 0.000 description 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 1
- 229960004414 clomethiazole Drugs 0.000 description 1
- 229960003608 clomifene Drugs 0.000 description 1
- GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 235000019316 curdlan Nutrition 0.000 description 1
- 229940078035 curdlan Drugs 0.000 description 1
- 229960003843 cyproterone Drugs 0.000 description 1
- 229960000978 cyproterone acetate Drugs 0.000 description 1
- 230000001120 cytoprotective effect Effects 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 229940124581 decongestants Drugs 0.000 description 1
- 229960001853 demegestone Drugs 0.000 description 1
- JWAHBTQSSMYISL-MHTWAQMVSA-N demegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(C)[C@@]1(C)CC2 JWAHBTQSSMYISL-MHTWAQMVSA-N 0.000 description 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 1
- 229960004976 desogestrel Drugs 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003949 dexpanthenol Drugs 0.000 description 1
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960003075 dibenzepin Drugs 0.000 description 1
- PCYQQSKDZQTOQG-NXEZZACHSA-N dibutyl (2r,3r)-2,3-dihydroxybutanedioate Chemical compound CCCCOC(=O)[C@H](O)[C@@H](O)C(=O)OCCCC PCYQQSKDZQTOQG-NXEZZACHSA-N 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960001912 dicoumarol Drugs 0.000 description 1
- DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 description 1
- 229960003309 dienogest Drugs 0.000 description 1
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 229960000648 digitoxin Drugs 0.000 description 1
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
- 229960000920 dihydrocodeine Drugs 0.000 description 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 description 1
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 description 1
- HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 description 1
- 229960004704 dihydroergotamine Drugs 0.000 description 1
- 229940031769 diisobutyl adipate Drugs 0.000 description 1
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 1
- 229960001826 dimethylphthalate Drugs 0.000 description 1
- 229960001992 dimetindene Drugs 0.000 description 1
- MVMQESMQSYOVGV-UHFFFAOYSA-N dimetindene Chemical compound CN(C)CCC=1CC2=CC=CC=C2C=1C(C)C1=CC=CC=N1 MVMQESMQSYOVGV-UHFFFAOYSA-N 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 229940120889 dipyrone Drugs 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- FTZLWXQKVFFWLY-UHFFFAOYSA-L disodium;2,5-dichloro-4-[3-methyl-5-oxo-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazol-1-yl]benzenesulfonate Chemical compound [Na+].[Na+].CC1=NN(C=2C(=CC(=C(Cl)C=2)S([O-])(=O)=O)Cl)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 FTZLWXQKVFFWLY-UHFFFAOYSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 description 1
- 230000003291 dopaminomimetic effect Effects 0.000 description 1
- 229960005426 doxepin Drugs 0.000 description 1
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 description 1
- 229960002065 drotaverine Drugs 0.000 description 1
- OMFNSKIUKYOYRG-MOSHPQCFSA-N drotaverine Chemical compound C1=C(OCC)C(OCC)=CC=C1\C=C/1C2=CC(OCC)=C(OCC)C=C2CCN\1 OMFNSKIUKYOYRG-MOSHPQCFSA-N 0.000 description 1
- 229960004913 dydrogesterone Drugs 0.000 description 1
- JGMOKGBVKVMRFX-HQZYFCCVSA-N dydrogesterone Chemical compound C1=CC2=CC(=O)CC[C@@]2(C)[C@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 JGMOKGBVKVMRFX-HQZYFCCVSA-N 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002895 emetic Substances 0.000 description 1
- 229960000309 enalapril maleate Drugs 0.000 description 1
- OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 229960003575 estradiol acetate Drugs 0.000 description 1
- FHXBMXJMKMWVRG-SLHNCBLASA-N estradiol acetate Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2CCC3=CC(OC(=O)C)=CC=C3[C@H]21 FHXBMXJMKMWVRG-SLHNCBLASA-N 0.000 description 1
- 229950002007 estradiol benzoate Drugs 0.000 description 1
- 229960005416 estradiol cypionate Drugs 0.000 description 1
- RFWTZQAOOLFXAY-BZDYCCQFSA-N estradiol enanthate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC2 RFWTZQAOOLFXAY-BZDYCCQFSA-N 0.000 description 1
- 229960004766 estradiol valerate Drugs 0.000 description 1
- FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 1
- 229960001842 estramustine Drugs 0.000 description 1
- 229960003836 estriol succinate Drugs 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- 229950008385 estrone sulphate Drugs 0.000 description 1
- HNYFYAGIZMHSFC-UHFFFAOYSA-N ethoxy-(1-methoxyethoxy)-(6-methyl-2-propan-2-ylpyrimidin-4-yl)oxy-sulfanylidene-lambda5-phosphane Chemical compound COC(OP(=S)(OCC)OC1=NC(=NC(=C1)C)C(C)C)C HNYFYAGIZMHSFC-UHFFFAOYSA-N 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 description 1
- 229960004695 etilefrine Drugs 0.000 description 1
- 229960003501 etofibrate Drugs 0.000 description 1
- XXRVYAFBUDSLJX-UHFFFAOYSA-N etofibrate Chemical compound C=1C=CN=CC=1C(=O)OCCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 XXRVYAFBUDSLJX-UHFFFAOYSA-N 0.000 description 1
- KYAKGJDISSNVPZ-UHFFFAOYSA-N etofylline clofibrate Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KYAKGJDISSNVPZ-UHFFFAOYSA-N 0.000 description 1
- 229950009036 etofylline clofibrate Drugs 0.000 description 1
- 229960002941 etonogestrel Drugs 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 1
- 229960002297 fenofibrate Drugs 0.000 description 1
- 229960001022 fenoterol Drugs 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 229960000449 flecainide Drugs 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 229960002200 flunitrazepam Drugs 0.000 description 1
- 229940124307 fluoroquinolone Drugs 0.000 description 1
- 229960002419 flupentixol Drugs 0.000 description 1
- JKQQZJHNUVDHKP-SZMVRVGJSA-N flurogestone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@]2(F)[C@H]1[C@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@]1(C)C[C@@H]2O JKQQZJHNUVDHKP-SZMVRVGJSA-N 0.000 description 1
- 229960002074 flutamide Drugs 0.000 description 1
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 229940068517 fruit extracts Drugs 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 239000000451 gelidium spp. gum Substances 0.000 description 1
- 229960003627 gemfibrozil Drugs 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229960001764 glibornuride Drugs 0.000 description 1
- RMTYNAPTNBJHQI-LLDVTBCESA-N glibornuride Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)N[C@H]1[C@H](C2(C)C)CC[C@@]2(C)[C@H]1O RMTYNAPTNBJHQI-LLDVTBCESA-N 0.000 description 1
- 229960003236 glisoxepide Drugs 0.000 description 1
- ZKUDBRCEOBOWLF-UHFFFAOYSA-N glisoxepide Chemical compound O1C(C)=CC(C(=O)NCCC=2C=CC(=CC=2)S(=O)(=O)NC(=O)NN2CCCCCC2)=N1 ZKUDBRCEOBOWLF-UHFFFAOYSA-N 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- IRPYFWIZKIOHQN-XTZHGVARSA-N gold;[(2r,3r,4s,5r,6s)-3,4,5-triacetyloxy-6-sulfanyloxan-2-yl]methyl acetate;triethylphosphane Chemical compound [Au].CC[PH+](CC)CC.CC(=O)OC[C@H]1O[C@@H]([S-])[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O IRPYFWIZKIOHQN-XTZHGVARSA-N 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 229960001442 gonadorelin Drugs 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 229940094892 gonadotropins Drugs 0.000 description 1
- ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- WDPIZEKLJKBSOZ-UHFFFAOYSA-M green s Chemical compound [Na+].C1=CC(N(C)C)=CC=C1C(C=1C2=CC=C(C=C2C=C(C=1O)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](C)C)C=C1 WDPIZEKLJKBSOZ-UHFFFAOYSA-M 0.000 description 1
- 229960002867 griseofulvin Drugs 0.000 description 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 229960003878 haloperidol Drugs 0.000 description 1
- 239000007887 hard shell capsule Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- UYXAWHWODHRRMR-UHFFFAOYSA-N hexobarbital Chemical compound O=C1N(C)C(=O)NC(=O)C1(C)C1=CCCCC1 UYXAWHWODHRRMR-UHFFFAOYSA-N 0.000 description 1
- 229960002456 hexobarbital Drugs 0.000 description 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
- 229960002003 hydrochlorothiazide Drugs 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229960003313 hydroflumethiazide Drugs 0.000 description 1
- DMDGGSIALPNSEE-UHFFFAOYSA-N hydroflumethiazide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O DMDGGSIALPNSEE-UHFFFAOYSA-N 0.000 description 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 description 1
- 229960001410 hydromorphone Drugs 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 229940065346 hydroxyprogesterone acetate Drugs 0.000 description 1
- 229950000801 hydroxyprogesterone caproate Drugs 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000000055 hyoplipidemic effect Effects 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000014413 iron hydroxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical class [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 1
- ZTKMNYDOFAYRAK-UHFFFAOYSA-N isoacronycine Natural products CN1C2=CC=CC=C2C(=O)C2=C1C=C1OC(C)(C)C=CC1=C2OC ZTKMNYDOFAYRAK-UHFFFAOYSA-N 0.000 description 1
- 229960000201 isosorbide dinitrate Drugs 0.000 description 1
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 1
- 229960003827 isosorbide mononitrate Drugs 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000010699 lard oil Substances 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 229950008325 levothyroxine Drugs 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 229960001571 loperamide Drugs 0.000 description 1
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 1
- 229960004391 lorazepam Drugs 0.000 description 1
- 229940040129 luteinizing hormone Drugs 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- LUEWUZLMQUOBSB-OUBHKODOSA-N maltotetraose Chemical group O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O[C@@H]3[C@@H](O[C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-OUBHKODOSA-N 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229960002225 medazepam Drugs 0.000 description 1
- 229960004616 medroxyprogesterone Drugs 0.000 description 1
- 229960003846 melengestrol acetate Drugs 0.000 description 1
- 229960001861 melperone Drugs 0.000 description 1
- 229960001390 mestranol Drugs 0.000 description 1
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 description 1
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
- 229960003105 metformin Drugs 0.000 description 1
- VRQVVMDWGGWHTJ-CQSZACIVSA-N methotrimeprazine Chemical compound C1=CC=C2N(C[C@H](C)CN(C)C)C3=CC(OC)=CC=C3SC2=C1 VRQVVMDWGGWHTJ-CQSZACIVSA-N 0.000 description 1
- 229940042053 methotrimeprazine Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 229960004503 metoclopramide Drugs 0.000 description 1
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 229960003404 mexiletine Drugs 0.000 description 1
- 229960003955 mianserin Drugs 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- XLFWDASMENKTKL-UHFFFAOYSA-N molsidomine Chemical compound O1C(N=C([O-])OCC)=C[N+](N2CCOCC2)=N1 XLFWDASMENKTKL-UHFFFAOYSA-N 0.000 description 1
- 229960004027 molsidomine Drugs 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000000510 mucolytic effect Effects 0.000 description 1
- 229940066491 mucolytics Drugs 0.000 description 1
- 229940038727 mucopolysaccharide polysulfate Drugs 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 229940040493 myrtol Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 229960004255 nadolol Drugs 0.000 description 1
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 1
- 229960004719 nandrolone Drugs 0.000 description 1
- NPAGDVCDWIYMMC-IZPLOLCNSA-N nandrolone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 NPAGDVCDWIYMMC-IZPLOLCNSA-N 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960001597 nifedipine Drugs 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- KJONHKAYOJNZEC-UHFFFAOYSA-N nitrazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1 KJONHKAYOJNZEC-UHFFFAOYSA-N 0.000 description 1
- 229960001454 nitrazepam Drugs 0.000 description 1
- 229960005425 nitrendipine Drugs 0.000 description 1
- 229960000564 nitrofurantoin Drugs 0.000 description 1
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
- 229960004911 nomegestrol Drugs 0.000 description 1
- KZUIYQJTUIACIG-YBZCJVABSA-N nomegestrol Chemical compound C1=C(C)C2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 KZUIYQJTUIACIG-YBZCJVABSA-N 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 229960001858 norethynodrel Drugs 0.000 description 1
- 229960001856 norfenefrine Drugs 0.000 description 1
- LRCXRAABFLIVAI-UHFFFAOYSA-N norfenefrine Chemical compound NCC(O)C1=CC=CC(O)=C1 LRCXRAABFLIVAI-UHFFFAOYSA-N 0.000 description 1
- 229960001180 norfloxacin Drugs 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
- 229960000417 norgestimate Drugs 0.000 description 1
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 1
- 229960002831 norgestrienone Drugs 0.000 description 1
- GVDMJXQHPUYPHP-FYQPLNBISA-N norgestrienone Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)C#C)C=C3)C3=C21 GVDMJXQHPUYPHP-FYQPLNBISA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229960004535 oxazepam Drugs 0.000 description 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
- GDYUVHBMFVMBAF-LIRRHRJNSA-N oxyfedrine Chemical compound COC1=CC=CC(C(=O)CCN[C@@H](C)[C@H](O)C=2C=CC=CC=2)=C1 GDYUVHBMFVMBAF-LIRRHRJNSA-N 0.000 description 1
- 229960001818 oxyfedrine Drugs 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 239000004177 patent blue V Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229960001476 pentoxifylline Drugs 0.000 description 1
- 229960003893 phenacetin Drugs 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- GVKCHTBDSMQENH-UHFFFAOYSA-L phloxine B Chemical compound [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GVKCHTBDSMQENH-UHFFFAOYSA-L 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- RMHMFHUVIITRHF-UHFFFAOYSA-N pirenzepine Chemical compound C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 description 1
- 229960004633 pirenzepine Drugs 0.000 description 1
- 229960001085 piretanide Drugs 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 235000012731 ponceau 4R Nutrition 0.000 description 1
- 239000004175 ponceau 4R Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 description 1
- 229960002393 primidone Drugs 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 229960001584 promegestone Drugs 0.000 description 1
- QFFCYTLOTYIJMR-XMGTWHOFSA-N promegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)CC)(C)[C@@]1(C)CC2 QFFCYTLOTYIJMR-XMGTWHOFSA-N 0.000 description 1
- 229960000203 propafenone Drugs 0.000 description 1
- JWHAUXFOSRPERK-UHFFFAOYSA-N propafenone Chemical compound CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JWHAUXFOSRPERK-UHFFFAOYSA-N 0.000 description 1
- HOCWPKXKMNXINF-XQERAMJGSA-N propicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(CC)OC1=CC=CC=C1 HOCWPKXKMNXINF-XQERAMJGSA-N 0.000 description 1
- 229960003672 propicillin Drugs 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229960001327 pyridoxal phosphate Drugs 0.000 description 1
- SIXLXDIJGIWWFU-UHFFFAOYSA-N pyritinol Chemical compound OCC1=C(O)C(C)=NC=C1CSSCC1=CN=C(C)C(O)=C1CO SIXLXDIJGIWWFU-UHFFFAOYSA-N 0.000 description 1
- 229960004986 pyritinol Drugs 0.000 description 1
- 229960001424 quinestrol Drugs 0.000 description 1
- PWZUUYSISTUNDW-VAFBSOEGSA-N quinestrol Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@]4(O)C#C)C)CC2=CC=3OC1CCCC1 PWZUUYSISTUNDW-VAFBSOEGSA-N 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000012739 red 2G Nutrition 0.000 description 1
- 239000004180 red 2G Substances 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical group [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- 229940084026 sodium valproate Drugs 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- GMJHUSJLZXFFQJ-UHFFFAOYSA-N soquinolol Chemical compound C1N(C=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C GMJHUSJLZXFFQJ-UHFFFAOYSA-N 0.000 description 1
- 229950000137 soquinolol Drugs 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- 238000010922 spray-dried dispersion Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229960002135 sulfadimidine Drugs 0.000 description 1
- 229960000654 sulfafurazole Drugs 0.000 description 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 1
- 229960005158 sulfamethizole Drugs 0.000 description 1
- VACCAVUAMIDAGB-UHFFFAOYSA-N sulfamethizole Chemical compound S1C(C)=NN=C1NS(=O)(=O)C1=CC=C(N)C=C1 VACCAVUAMIDAGB-UHFFFAOYSA-N 0.000 description 1
- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 1
- 229960001544 sulfathiazole Drugs 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- 229960004940 sulpiride Drugs 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- PYVFWTPEBMRKSR-UHFFFAOYSA-N tanaproget Chemical compound CN1C(C#N)=CC=C1C1=CC=C(NC(=S)OC2(C)C)C2=C1 PYVFWTPEBMRKSR-UHFFFAOYSA-N 0.000 description 1
- 229950001471 tanaproget Drugs 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960000351 terfenadine Drugs 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960005214 tetrazepam Drugs 0.000 description 1
- IQWYAQCHYZHJOS-UHFFFAOYSA-N tetrazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CCCCC1 IQWYAQCHYZHJOS-UHFFFAOYSA-N 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 description 1
- 229960001023 tibolone Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 229960002277 tolazamide Drugs 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 description 1
- JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 description 1
- 229950008546 trimegestone Drugs 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000001018 xanthene dye Substances 0.000 description 1
- 235000019235 yellow 2G Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229940124629 β-receptor antagonist Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Abstract
Description
を含む。
カプセルを以下のように作製した。まずプルラン(22重量%プルラン)の水溶液443リットルを溶融物タンクに加え、65℃に溶液を加熱することによって水性浸漬溶液を調製した。65℃の水3リットル中で1.65kgの塩化カリウムを混合し、結果として得られる溶液を溶融物タンクに加えて撹拌した。カッパカラギーナン(CP Kelco, Denmarkから入手可能)460.5gを以下のように溶融物タンクに加えた。カラギーナン115.13gのアリコートを3リットルの冷水と混合し、次いで溶融物タンクに加え、撹拌した。カラギーナン115.13gの追加の3つのアリコートを同様に調製し、溶融物タンクに加えた。次いで、その溶液を50RPMで60分間混合し、次いで真空下に配置し、60分間さらに混合した。次いで、溶液を真空下に33RPMで60分間混合した。次いで、溶融物タンク中の160リットルの溶液を移動タンクに分配した。次いで、スクロースココエート(ESAC80、Tensac, Argentinaから入手可能)の12.5重量%水溶液1600gを移動タンクに加え、撹拌して浸漬組成物を形成した。次いで、水を加えて800cpsの粘度を達成した。
この実施例で、実施例1に従って作製したオーガニックプルランから生産したカプセル(カプセルA)、及びCapsugel, Greenwood, SCからのPlantcaps(登録商標)カプセル(カプセルB)を、フレーム原子吸収分光法を使用し、標準プロトコルSM3111Bを使用して、Mg2+及びK+含有率について分析した。さらに、これらのカプセル中のCa2+含有率も、フレーム原子吸収分光法を使用し標準プロトコルSM3111Dを使用して測定した。各カプセルバッチを3回繰り返して分析した。この分析から、Mg2+とCa2+の両方の濃度がカプセルAでカプセルBより大きいと判断した。さらに、カプセルAのカプセルは、一価陽イオン(K+)と二価陽イオン(Mg2+及びCa2+)の比が低い。
Claims (25)
- カプセルであって、
a)前記カプセルの少なくとも70重量%の量のプルラン;
b)前記カプセルの少なくとも0.01重量%の量の凝固系;
c)スクログリセリド若しくは糖脂肪酸エステル又はこれらの混合物を含む界面活性剤
を含み、前記重量%の量は前記カプセル中に存在する水を除外する、カプセル。 - カプセルであって、
a)前記カプセルの少なくとも70重量%の量のプルラン;
b)前記カプセルの少なくとも0.01重量%の量の凝固系;
c)前記カプセルの少なくとも0.2重量%の量のスクログリセリド、糖脂肪酸エステル、及びこれらの混合物からなる群から選択される界面活性剤
から本質的になり、前記重量%の量は前記カプセル中に存在する水を除外する、カプセル。 - 前記プルランがオーガニック発酵工程を使用して製造される、請求項1又は2に記載のカプセル。
- 前記糖脂肪酸エステルが、グルコース、フルクトース、ガラクトース、スクロース、マルトース、トレハロース、ラクトース及びラフィノースからなる群から選択される糖ヘッド基を含む、請求項1又は2に記載のカプセル。
- 前記スクログリセリド又は前記糖脂肪酸エステルが、やし油、パーム油、パーム核油、大豆油、なたね油、ひまわり油、綿実油、ピーナッツ油、オリーブ油、キャノーラ油、ヒマシ油、とうもろこし油、アマニ油、サフラワー油及びゴマ油からなる群から選択される植物油の脂肪酸エステルに由来する親油性基を含む、請求項1又は2に記載のカプセル。
- 前記界面活性剤がスクロース脂肪酸エステルである、請求項1又は2に記載のカプセル。
- 前記界面活性剤がスクログリセリドである、請求項1又は2に記載のカプセル。
- 前記界面活性剤がやし油の脂肪酸に由来する、請求項6又は7に記載のカプセル。
- 前記界面活性剤がスクロースココエートである、請求項1又は2に記載のカプセル。
- 前記界面活性剤が、組成物の0.2重量%〜2重量%、又はカプセル組成物の0.4重量%〜1.5重量%、又はカプセル組成物の0.5重量%〜1重量%の量(水を除外する)で存在する、請求項1〜9のいずれかに記載のカプセル。
- 少なくとも1種の金属イオン封鎖剤をさらに含む、請求項1〜10のいずれかに記載のカプセル。
- 可塑剤又は/及び着香剤をさらに含む、請求項1〜11のいずれかに記載のカプセル。
- 組成物の重量に対して約0%〜10%の範囲の着色剤をさらに含む、請求項1〜12のいずれかに記載のカプセル。
- コーティングを含む、請求項1〜13のいずれかに記載のカプセル。
- 請求項1又は2に記載のカプセル中に封入されているカプレット。
- 請求項1又は2に記載のカプセルを製造する方法であって、
a)プルラン、前記凝固系及び前記界面活性剤を含む水性浸漬組成物を準備するステップ;
b)金型ピンを前記水性浸漬組成物に浸漬するステップ;
c)前記金型ピンのそれぞれを覆ってフィルムが形成されるように、前記水性浸漬組成物から前記金型ピンを引き出すステップ;
d)前記フィルムを乾燥して前記金型ピンに固体コーティングを形成するステップ;
e)前記金型ピンから前記固体コーティングを除去してカプセル殻を得るステップ
を含む方法。 - 前記金型ピンがレシチン及び植物油の混合物を用いて潤滑される、請求項13に記載の方法。
- 前記固体コーティングがレシチン及び植物油の混合物を用いて潤滑される、請求項13に記載の方法。
- 前記レシチンが、大豆レシチン、ピーナッツレシチン、綿実レシチン、ひまわりレシチン、なたねレシチン、とうもろこしレシチン及び落花生レシチンからなる群から選択され、好ましくはひまわりレシチンである、請求項17又は18に記載の方法。
- 前記植物油が、やし油、パーム油、パーム核油、大豆油、なたね油、ひまわり油、綿実油、ピーナッツ油、オリーブ油、キャノーラ油、ヒマシ油、とうもろこし油、アマニ油、サフラワー油及びゴマ油からなる群から選択される、請求項17又は18に記載の方法。
- 滑剤が、やし油及びひまわりレシチンの混合物を含む、請求項14に記載の方法。
- 滑剤が、スクログリセリド又はスクログリセリドとレシチンの混合物を含む、請求項14に記載の方法。
- カプセルであって、
a)前記カプセルの少なくとも70重量%の量のプルラン;
b)前記カプセルの少なくとも0.01重量%の量の凝固系;
c)スクログリセリド又は糖脂肪酸エステル又はこれらの混合物を含む界面活性剤
を含み、前記重量%の量は前記カプセル中に存在する水を除外し、少なくとも200mg/kg、又は少なくとも300mg/kg、又はさらには少なくとも500mg/kgのCa2+含有量を有する、カプセル。 - 少なくとも30mg/kg、又は少なくとも40mg/kg、又はさらには少なくとも50mg/kgのMg2+含有量を有する、請求項23に記載のカプセル。
- K+/(Mg2++Ca2+)の比が、50未満、又は40未満、又は30未満、又はさらには20未満である、請求項23に記載のカプセル。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022205189A JP2023052025A (ja) | 2017-04-14 | 2022-12-22 | プルランカプセル |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762485854P | 2017-04-14 | 2017-04-14 | |
US62/485,854 | 2017-04-14 | ||
PCT/IB2018/000448 WO2018189584A1 (en) | 2017-04-14 | 2018-04-10 | Pullulan capsules |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022205189A Division JP2023052025A (ja) | 2017-04-14 | 2022-12-22 | プルランカプセル |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2020516653A true JP2020516653A (ja) | 2020-06-11 |
JP2020516653A5 JP2020516653A5 (ja) | 2021-05-20 |
Family
ID=62152586
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019555931A Pending JP2020516653A (ja) | 2017-04-14 | 2018-04-10 | プルランカプセル |
JP2022205189A Pending JP2023052025A (ja) | 2017-04-14 | 2022-12-22 | プルランカプセル |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022205189A Pending JP2023052025A (ja) | 2017-04-14 | 2022-12-22 | プルランカプセル |
Country Status (8)
Country | Link |
---|---|
US (2) | US11576870B2 (ja) |
EP (1) | EP3609476A1 (ja) |
JP (2) | JP2020516653A (ja) |
CN (1) | CN110678170A (ja) |
AU (1) | AU2018251256B2 (ja) |
BR (1) | BR112019021391A2 (ja) |
CA (1) | CA3059527A1 (ja) |
WO (1) | WO2018189584A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7222911B2 (ja) | 2017-04-14 | 2023-02-15 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | プルランを作製する方法 |
US10899849B2 (en) | 2019-04-30 | 2021-01-26 | Lefan Capsule International Inc | Method for the production of pullulan capsules |
US10894971B1 (en) * | 2019-06-26 | 2021-01-19 | Lefan Capsule International Inc | Method for the production of pullulan soft capsules |
CA3155876A1 (en) * | 2019-10-09 | 2021-04-15 | R.P. Scherer Technologies, Llc | NON-ANIMAL SOFT GEL CAPSULE FORMULATIONS, METHODS OF PREPARATION AND METHODS OF USE |
CN112089701A (zh) * | 2020-10-30 | 2020-12-18 | 华侨大学 | 一种维生素e植物软胶囊囊皮及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000336028A (ja) * | 1999-03-24 | 2000-12-05 | Fuji Capsule Kk | カプセル剤 |
WO2002088246A1 (fr) * | 2001-04-26 | 2002-11-07 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Objet moule ayant une teneur de pullulane elevee, son procede de production et son utilisation |
JP2003505565A (ja) * | 1999-07-22 | 2003-02-12 | ワーナー−ランバート・カンパニー | プルラン膜組成物 |
JP2007536308A (ja) * | 2004-05-04 | 2007-12-13 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 改良されたプルランカプセル |
JP2015518052A (ja) * | 2012-05-31 | 2015-06-25 | レプロス セラピューティクス インコーポレイティド | 抗プロゲスチンの経膣送達用製剤およびその送達方法 |
Family Cites Families (544)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE261609C (ja) | ||||
JPS5639630B1 (ja) | 1968-04-01 | 1981-09-14 | ||
US3561770A (en) | 1968-10-07 | 1971-02-09 | Federal Mogul Corp | Shaft seal |
US3654088A (en) | 1969-10-22 | 1972-04-04 | Staley Mfg Co A E | Method of producing amylo-1 6-glucosidase |
US3784390A (en) | 1971-07-23 | 1974-01-08 | Hayashibara Biochem Lab | Shaped bodies of pullulan and their use |
JPS5136360B2 (ja) | 1971-10-11 | 1976-10-07 | ||
FR2167986A1 (en) | 1972-01-13 | 1973-08-24 | Hayashibara Biochem Lab | Low calorie food - contains pullulan as partial replacement for starch |
BE793671A (fr) | 1972-01-13 | 1973-05-02 | Hayashibara Biochem Lab | Composition alimentaire a teneur reduite en calories |
JPS5142199B2 (ja) | 1972-09-04 | 1976-11-13 | ||
US3871892A (en) | 1972-12-18 | 1975-03-18 | Hayashibara Biochem Lab | Shaped bodies of pullulan esters and their use |
JPS5222029B2 (ja) | 1972-12-18 | 1977-06-14 | ||
JPS519812B2 (ja) | 1973-01-19 | 1976-03-30 | ||
JPS5224054B2 (ja) | 1973-01-23 | 1977-06-29 | ||
JPS5315542B2 (ja) | 1973-03-01 | 1978-05-25 | ||
US3779972A (en) | 1973-03-15 | 1973-12-18 | Tenneco Chem | Preservatives for aqueous compositions which contain addition polymers |
JPS5626400B2 (ja) | 1973-03-17 | 1981-06-18 | ||
JPS5638599B2 (ja) | 1973-04-11 | 1981-09-08 | ||
JPS5012246A (ja) | 1973-06-01 | 1975-02-07 | ||
JPS5123573B2 (ja) | 1973-06-26 | 1976-07-17 | ||
JPS5551080B2 (ja) | 1973-09-05 | 1980-12-22 | ||
JPS5247042B2 (ja) | 1973-09-29 | 1977-11-30 | ||
JPS5060530A (ja) | 1973-09-29 | 1975-05-24 | ||
JPS5231019B2 (ja) | 1973-10-16 | 1977-08-12 | ||
US3960685A (en) | 1973-11-12 | 1976-06-01 | Sumitomo Chemical Company, Limited | Photosensitive resin composition containing pullulan or esters thereof |
JPS5542635B2 (ja) | 1974-01-31 | 1980-10-31 | ||
JPS5411358B2 (ja) | 1974-02-01 | 1979-05-14 | ||
JPS5318071B2 (ja) | 1974-02-01 | 1978-06-13 | ||
US4018233A (en) | 1974-02-05 | 1977-04-19 | Sumitomo Chemical Company Limited | Shaped matters of tobaccos and process for producing the same |
JPS5325856B2 (ja) | 1974-02-06 | 1978-07-29 | ||
JPS5414678B2 (ja) | 1974-02-23 | 1979-06-08 | ||
JPS50117592A (ja) | 1974-02-27 | 1975-09-13 | ||
FR2262682B1 (ja) | 1974-02-28 | 1977-04-15 | Sumitomo Chemical Co | |
JPS5318077B2 (ja) | 1974-03-01 | 1978-06-13 | ||
JPS5338105B2 (ja) | 1974-03-01 | 1978-10-13 | ||
JPS5345822B2 (ja) | 1974-03-15 | 1978-12-09 | ||
JPS5335165B2 (ja) | 1974-03-20 | 1978-09-26 | ||
US3976605A (en) | 1974-03-28 | 1976-08-24 | Sumitomo Chemical Company, Limited | Foamed plastics of resin compositions comprising pullulan type resins and thermoplastic resins and process for producing the same |
JPS543707B2 (ja) | 1974-03-29 | 1979-02-26 | ||
JPS5625379B2 (ja) | 1974-05-18 | 1981-06-11 | ||
JPS514272A (ja) | 1974-06-29 | 1976-01-14 | Sumitomo Chemical Co | |
JPS511699A (en) | 1974-06-29 | 1976-01-08 | Sumitomo Chemical Co | Tabakoseikeibutsuno seizohoho |
JPS517189A (en) | 1974-07-01 | 1976-01-21 | Takeda Chemical Industries Ltd | Koseibutsushitsuno seizoho |
US4032403A (en) | 1974-07-17 | 1977-06-28 | Kabushiki-Kaisha Hayashibara Selbutsukagaku Kenkyujo | Process for the production of saccharified starch products wherein maltose is the predominant constituent |
JPS5144163A (ja) | 1974-10-11 | 1976-04-15 | Sumitomo Chemical Co | |
JPS5152484A (en) | 1974-10-18 | 1976-05-10 | Sumitomo Chemical Co | Pururanno ryusanesuteru oyobi sono enruino seizohoho |
FR2301497A1 (fr) | 1975-02-24 | 1976-09-17 | Sumitomo Chemical Co | Composition d'engrais |
US4152170A (en) | 1975-06-18 | 1979-05-01 | Sumitomo Chemical Company, Ltd. | Cross-linked pullulan |
JPS51151745A (en) | 1975-06-20 | 1976-12-27 | Sumitomo Chem Co Ltd | Pullulan composition |
JPS5213812A (en) | 1975-07-11 | 1977-02-02 | Hayashibara Biochem Lab | Production of coated seed |
JPS52109535A (en) | 1976-03-11 | 1977-09-13 | Sumitomo Chem Co Ltd | Solid adhesive |
JPS5840479B2 (ja) | 1976-04-24 | 1983-09-06 | 株式会社林原生物化学研究所 | アミラゼ活性阻害物質を用いるプルランの製造方法 |
JPS5326867A (en) | 1976-08-24 | 1978-03-13 | Hayashibara Biochem Lab | Method of endowment of waterrproof ability of formed product belonging to poluran series |
JPS5943481B2 (ja) | 1976-11-08 | 1984-10-22 | 住友化学工業株式会社 | プルランアミノアルキルエ−テル |
JPS5379972A (en) | 1976-12-24 | 1978-07-14 | Hayashibara Biochem Lab | Method for heattsealing pururan film |
CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
JPS5940557B2 (ja) | 1977-03-29 | 1984-10-01 | 住友化学工業株式会社 | 被覆ア−ク溶接棒の製造法 |
JPS5844084B2 (ja) | 1977-04-01 | 1983-09-30 | 住友化学工業株式会社 | イオン性プルランゲルの製造法 |
JPS5437889A (en) | 1977-08-30 | 1979-03-20 | Ajinomoto Co Inc | Preparation of polysaccharide |
JPS5437888A (en) | 1977-08-30 | 1979-03-20 | Ajinomoto Co Inc | Preparation of pullulan |
JPS6054322B2 (ja) | 1977-09-30 | 1985-11-29 | 株式会社林原生物化学研究所 | 成形物の製法 |
CS200778B1 (en) | 1978-07-05 | 1980-09-15 | Juraj Zemek | Method of producing pullulan |
JPS55118369A (en) | 1979-03-06 | 1980-09-11 | Hayashibara Biochem Lab Inc | Method of making beverage and food |
US4338398A (en) | 1979-03-20 | 1982-07-06 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Immobilization of starch degrading enzymes |
JPS6049164B2 (ja) | 1979-05-25 | 1985-10-31 | エーザイ株式会社 | 血漿増量剤 |
JPS5639022A (en) | 1979-09-05 | 1981-04-14 | Hayashibara Biochem Lab Inc | Preparation of vaccine |
JPS56147801A (en) | 1980-04-19 | 1981-11-17 | Hayashibara Biochem Lab Inc | Alpha-glycosylpullulan |
JPS5823847B2 (ja) | 1981-02-06 | 1983-05-18 | 株式会社 林原生物化学研究所 | 抗ヒト蛋白質抗体の製造方法 |
JPS57136528A (en) | 1981-02-09 | 1982-08-23 | Hayashibara Biochem Lab Inc | Preparation of viral vaccine |
GB2109391B (en) | 1981-11-11 | 1985-02-06 | Hayashibara Biochem Lab | Process for the production of a pullulan composition |
DE3147193A1 (de) | 1981-11-27 | 1983-06-01 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama | Verfahren zur herstellung einer pullulanzubereitung mit begrenzter molekulargewichtsverteilung, verfahren zur herstellung eines plasmaausdehnungsmittels, verfahren zur herstellung eines hyperkinesemittels unter verwendung der pullulanzubereitung und diese mittel |
JPS6016217B2 (ja) | 1981-12-01 | 1985-04-24 | 株式会社ロツテ | フイルム状ダイエツト甘味料 |
FR2517326B1 (fr) | 1981-12-01 | 1989-09-01 | Hayashibara Biochem Lab | Production d'une preparation de pullulane a repartition etroite de masses moleculaires |
JPS58213076A (ja) | 1982-06-05 | 1983-12-10 | Hayashibara Biochem Lab Inc | 摺動部シ−ル剤 |
US4562020A (en) | 1982-12-11 | 1985-12-31 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for producing self-supporting glucan film |
US4656066A (en) | 1982-12-20 | 1987-04-07 | Warner-Lambert Company | Apparatus and method for sealing capsules |
US4539060A (en) | 1983-02-18 | 1985-09-03 | Warner-Lambert Company | Apparatus and method of sealing capsules |
JPS59172566A (ja) | 1983-03-19 | 1984-09-29 | Nichiden Kagaku Kk | 糊剤およびその製造方法 |
FR2528060B1 (fr) | 1983-06-03 | 1986-08-08 | Hayashibara Biochem Lab | Composition pour l'obturation d'une zone de contact de glissement |
JPS6049080A (ja) | 1983-08-27 | 1985-03-18 | Hayashibara Biochem Lab Inc | 摺動部シ−ル剤 |
US4650666A (en) | 1983-11-30 | 1987-03-17 | Dainippon Pharmaceutical Co., Ltd. | Pullulan and sugar coated pharmaceutical composition |
JPH07116268B2 (ja) | 1984-01-09 | 1995-12-13 | 大西 靖彦 | デキストランの陰イオン性部分置換体とオレフィン化合物との共重合体の製法 |
US4745042A (en) | 1984-04-19 | 1988-05-17 | Matsushita Electric Industrial Co., Ltd. | Water-soluble photopolymer and method of forming pattern by use of the same |
GB8414272D0 (en) | 1984-06-05 | 1984-07-11 | Cpc International Inc | Enzymatic hydrolysis |
JPS60258125A (ja) | 1984-06-06 | 1985-12-20 | Hayashibara Biochem Lab Inc | 蛋白性生理活性物質を含有する水溶性乾燥物 |
US4816445A (en) | 1984-06-21 | 1989-03-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Crystalline alpha-maltose |
US4673633A (en) | 1984-06-28 | 1987-06-16 | Cooperbiomedical, Inc. | Method of determining cystic fibrosis ciliostatic factor |
JPS61103889A (ja) | 1984-10-24 | 1986-05-22 | Hayashibara Biochem Lab Inc | 結晶エルロ−ス及びそれを含有する含蜜結晶並びにそれらの製造方法及び用途 |
RO90437A2 (ro) | 1984-12-21 | 1986-10-30 | Intreprinderea De Antibiotice,Ro | Procedeu de obtinere a unei polizaharide |
US4683298A (en) | 1985-01-10 | 1987-07-28 | British Columbia Research Council | Process for the preparation of aminated polysaccharide derivatives |
JPH0623088B2 (ja) | 1985-01-17 | 1994-03-30 | 株式会社コーセー | 化粧料 |
CN1017211B (zh) | 1985-04-01 | 1992-07-01 | 兴洋食品株式会社 | 花生米的焙煎加工法 |
JPH0755898B2 (ja) | 1985-05-20 | 1995-06-14 | 株式会社林原生物化学研究所 | 糖衣固形製剤の製造方法 |
US4628028A (en) | 1985-05-23 | 1986-12-09 | Cpc International Inc. | Novel thermostable pullulanase enzyme and method for its production |
CA1280705C (en) | 1985-09-13 | 1991-02-26 | Finn Kollerup | Solvents and process for extractive fermentation |
JPH0799730B2 (ja) | 1985-09-13 | 1995-10-25 | 株式会社日立製作所 | パターン形成方法 |
DE3539180A1 (de) | 1985-11-05 | 1987-05-07 | Consortium Elektrochem Ind | Aureobasidium-pullulans-stamm, herstellungsverfahren und verwendung |
US4610891A (en) | 1985-11-25 | 1986-09-09 | Zeria Shinyaku Kogyo Kabushiki Kaisha | Process for sugar-coating solid preparation |
JPH0692441B2 (ja) | 1986-03-03 | 1994-11-16 | 株式会社林原生物化学研究所 | β−D−グルカンとその製造方法及び用途 |
US5100877A (en) | 1986-05-21 | 1992-03-31 | Kuraray Co., Ltd. | Platinum containing pullulan derivatives and pharmaceutical compositions comprising the same |
US4962026A (en) | 1986-09-15 | 1990-10-09 | Enzyme Bio-Systems, Ltd. | Process for the production of panosyl derivatives |
JPH0739508B2 (ja) | 1986-11-11 | 1995-05-01 | 株式会社林原生物化学研究所 | プルラン・ポリエチレングリコ−ル会合物とその製造方法並びに用途 |
WO1988005458A1 (en) | 1987-01-17 | 1988-07-28 | Sumitomo Rubber Industries, Ltd. | Low-temperature insulating material |
US4822601A (en) * | 1987-03-13 | 1989-04-18 | R.I.T.A. Corporation | Cosmetic base composition with therapeutic properties |
JPH0789916B2 (ja) | 1987-03-28 | 1995-10-04 | 株式会社林原生物化学研究所 | マルトテトラオ−ス生成アミラ−ゼとその製造方法 |
JPS63283593A (ja) | 1987-05-13 | 1988-11-21 | Nichiden Kagaku Kk | プルランの製造方法 |
JPS6410946A (en) | 1987-07-01 | 1989-01-13 | Kanebo Ltd | Combined chewing gum and preparation thereof |
NZ225634A (en) | 1987-08-10 | 1991-03-26 | Merck & Co Inc | 10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine derivatives and pharmaceutical compositions |
EP0313993A1 (en) | 1987-10-20 | 1989-05-03 | Matsushita Electric Industrial Co., Ltd. | Pattern forming method |
FR2624135B1 (fr) | 1987-12-04 | 1990-04-13 | Rhone Poulenc Chimie | Procede de production de polysaccharides |
JP2560381B2 (ja) | 1988-01-29 | 1996-12-04 | 武田薬品工業株式会社 | 糖衣液、糖衣層及びその形成法 |
RO105830B1 (ro) | 1988-07-18 | 1992-12-30 | Inst De Cercetari Chimico Farm | Procedeu de obtinere, prin biosinteza, a exopolizaharidului de tip pullulan |
SU1559718A1 (ru) | 1989-01-08 | 1994-12-15 | Ленинградский химико-фармацевтический институт | Штамм гриба aureobasidium pullulans - продуцент экзополисахарида |
ES2067429T3 (es) | 1989-01-13 | 1996-12-16 | Fmc Corp | Geles de resolucion de polisacaridos y sistemas de geles para electroforesis en apilamiento. |
ATE132773T1 (de) | 1989-01-19 | 1996-01-15 | Takeda Chemical Industries Ltd | Formbare zusammensetzungen aus aktivierten kohlenstoff und daraus hergestellte geformte artikel |
JP2779963B2 (ja) | 1989-02-09 | 1998-07-23 | 株式会社林原生物化学研究所 | ビフィズス菌増殖促進剤 |
NO902087L (no) | 1989-06-05 | 1990-12-06 | Alko Ab Oy | Alfa-amylase-pullulanase-enzym og dna-sekvens som koder for dette, rekombinant dna-molekyl og en rekombinant klon som uttrykker enzymet. |
JPH085922B2 (ja) | 1989-06-19 | 1996-01-24 | 信越化学工業株式会社 | スルフィニルエチルプルランと、その製造方法 |
EP0405283A3 (en) | 1989-06-26 | 1991-03-06 | Enzyme Bio-Systems Ltd. | Novel thermoduric and aciduric pullulanase enzyme and method for its production |
ES2065449T3 (es) | 1989-08-31 | 1995-02-16 | Kao Corp | Pullulanasa alcalina, microorganismo que la produce y procedimiento para producirla. |
JP2838800B2 (ja) | 1989-09-02 | 1998-12-16 | 株式会社林原生物化学研究所 | 減感作剤 |
JPH0632613B2 (ja) | 1989-09-19 | 1994-05-02 | 花王株式会社 | α―アミラーゼ活性を有する新規なアルカリプルラナーゼY、これを産生する微生物及び新規なアルカリプルラナーゼYの製造法 |
US5147796A (en) | 1989-09-19 | 1992-09-15 | Kao Corporation | Alkaline pullulanase Y having α-amylase activity |
US5082803A (en) | 1989-09-21 | 1992-01-21 | Asahi Kogaku Kogyo Kabushiki Kaisha | Process for producing bone prosthesis |
DE69100961T2 (de) | 1990-03-05 | 1994-07-28 | House Food Industrial Co | Verfahren zur Herstellung von mit einem grünen Blatt bedeckter Süssware. |
US5264223A (en) | 1990-03-29 | 1993-11-23 | Japan Elanco Company, Ltd. | Hard capsule for pharmaceutical drugs and method for producing the same |
DE69133154T2 (de) | 1990-04-05 | 2003-07-24 | Kao Corp | Detergentzusammensetzung |
US5583039A (en) | 1990-06-07 | 1996-12-10 | Sunkyong Industries Ltd. | Escherichia coli containing a gene encoding a maltogenic amylase BLMA of Bacillus licheniformis and gene product produced by same |
PL164352B1 (pl) | 1990-09-28 | 1994-07-29 | Politechnika Lodzka | Sposób wytwarzania pululanu |
JP3011752B2 (ja) | 1990-10-23 | 2000-02-21 | フロイント産業株式会社 | 徐放性製剤およびその製造方法 |
JPH0848B2 (ja) | 1991-03-26 | 1996-01-10 | 小幡 美代子 | 豆 腐 |
TW209174B (ja) | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
JPH0515368A (ja) | 1991-07-05 | 1993-01-26 | Nagase Seikagaku Kogyo Kk | 新規プルラナーゼおよびその製造方法 |
JP3026857B2 (ja) | 1991-07-05 | 2000-03-27 | ナガセ生化学工業株式会社 | 新規プルラナーゼおよびその製造法 |
JP2512352B2 (ja) | 1991-07-25 | 1996-07-03 | 日本化成株式会社 | 高シアノエチル化プルランの製造方法 |
JPH0565222A (ja) | 1991-09-09 | 1993-03-19 | Fuji Capsule Kk | カプセル剤用プルラン配合皮膜及びカプセル剤 |
JPH0594667A (ja) | 1991-09-30 | 1993-04-16 | Toshiba Corp | 券類処理装置 |
JP2813784B2 (ja) | 1991-10-14 | 1998-10-22 | 信越化学工業株式会社 | カチオン化プルランの製造方法 |
US5268460A (en) | 1991-10-16 | 1993-12-07 | Shin-Estu Bio, Inc. | High molecular weight pullulan |
JP3098597B2 (ja) | 1991-12-02 | 2000-10-16 | 大日本印刷株式会社 | 湿し水組成物 |
JPH0710901A (ja) | 1991-12-27 | 1995-01-13 | Asahi Chem Ind Co Ltd | 多糖体m−100物質群およびその製造法 |
JP3232488B2 (ja) | 1992-08-20 | 2001-11-26 | 株式会社林原生物化学研究所 | プルラン高含有物とその製造方法並びに用途 |
JP3350823B2 (ja) | 1992-03-04 | 2002-11-25 | 株式会社林原生物化学研究所 | 結着剤とその用途 |
JPH0614789A (ja) | 1992-04-08 | 1994-01-25 | Ensuiko Sugar Refining Co Ltd | 分岐シクロデキストリンの製造方法 |
JP3078401B2 (ja) | 1992-05-29 | 2000-08-21 | 信越化学工業株式会社 | 高分子プルランの製造方法 |
JPH08502881A (ja) | 1992-07-28 | 1996-04-02 | バイオ ポリマーズ プロプライエタリー リミテッド | 工業、医薬品および化粧品における培養植物細胞ゴム質の使用 |
US5411945A (en) | 1992-08-29 | 1995-05-02 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Pullulan binder and its uses |
JP2939069B2 (ja) | 1992-11-13 | 1999-08-25 | 大正薬品工業株式会社 | ニカルジピン持続性製剤とその製造方法 |
JP3168550B2 (ja) | 1992-12-02 | 2001-05-21 | 株式会社林原生物化学研究所 | 脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品 |
KR960007615B1 (ko) | 1992-12-08 | 1996-06-07 | 주식회사 농심 | 미생물 연속 배양에 의한 무색소 풀루란의 생산방법 |
JP2931730B2 (ja) | 1992-12-24 | 1999-08-09 | ユニコロイド株式会社 | 油揚げ食品及びその製法 |
RU2034923C1 (ru) | 1993-06-11 | 1995-05-10 | Акционерное общество "Биотехнология" | Штамм бактерий bacillus subtilis - продуцент осахаривающей амилазы, расщепляющей пуллулан |
JP3537464B2 (ja) | 1993-07-12 | 2004-06-14 | 王子コーンスターチ株式会社 | 新規イソマルトオリゴ糖並びにそれを製造するための酵素 |
JPH0725903A (ja) | 1993-07-13 | 1995-01-27 | Shin Etsu Chem Co Ltd | 高純度カチオン化プルランの製造方法 |
JP3444629B2 (ja) | 1993-08-04 | 2003-09-08 | 株式会社林原生物化学研究所 | 氷温改善剤とその用途 |
JPH0759585A (ja) | 1993-08-20 | 1995-03-07 | Akebono Brake Res & Dev Center Ltd | プルランオリゴ糖の製造法 |
JP3512452B2 (ja) | 1993-12-21 | 2004-03-29 | 株式会社林原生物化学研究所 | ポリペプチドとその製造方法並びに用途 |
JPH07188291A (ja) | 1993-12-27 | 1995-07-25 | Hayashibara Biochem Lab Inc | 蛋白質とその製造方法並びに用途 |
CN1106448A (zh) | 1994-01-15 | 1995-08-09 | 管爱福 | 一种制作夜光开关的材料 |
JP3533239B2 (ja) | 1994-03-01 | 2004-05-31 | 株式会社林原生物化学研究所 | マルトヘキサオース・マルトヘプタオース生成アミラーゼとその製造方法並びに用途 |
JP3413288B2 (ja) | 1994-08-05 | 2003-06-03 | 高砂香料工業株式会社 | 粉末香味料の製造法 |
US5545553A (en) | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
FR2726564B1 (fr) | 1994-11-08 | 1997-04-04 | Shinetsu Chemical Co | Pullulan contenant du siloxane et un procede pour la preparation de celui-ci |
JP2959423B2 (ja) | 1994-12-01 | 1999-10-06 | シオノギクオリカプス株式会社 | カプセル用皮膜組成物 |
US5756123A (en) | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
JP2849047B2 (ja) | 1994-12-19 | 1999-01-20 | 大正薬品工業株式会社 | ジクロフェナクナトリウム持続性製剤およびその製法 |
JP2787764B2 (ja) | 1995-03-27 | 1998-08-20 | 株式会社林原生物化学研究所 | マルトテトラオースとそれを含有する飲食物 |
KR100392212B1 (ko) | 1995-03-30 | 2003-07-23 | 마쯔시다덴기산교 가부시키가이샤 | 이엘 시트 다이아프램 및 이것을 사용한 스위치 |
JP3585576B2 (ja) | 1995-06-20 | 2004-11-04 | 花王株式会社 | 高分子水分散体及びその製造方法 |
SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
JPH0977802A (ja) | 1995-09-12 | 1997-03-25 | Shin Etsu Chem Co Ltd | プルランの脱液方法 |
KR970062047A (ko) | 1996-02-07 | 1997-09-12 | 백운화 | 오우레오바시디움속 미생물 gm21을 이용한 고순도 플루란의 제조방법 |
RO116203B1 (ro) | 1996-06-28 | 2000-11-30 | Institutul Naţional De Cercetare- Dezvoltare Chimico- Farmaceutică - Iccf | Microorganism producător de polizaharide |
RO116212B1 (ro) | 1996-07-24 | 2000-11-30 | Institutul De Cercetări Chimico-Farmaceutice | Procedeu de obţinere a unui polizaharid, de tip pullulan, prin fermentaţie |
AU3868297A (en) | 1996-08-27 | 1998-03-19 | San-Ei Gen F.F.I., Inc. | Novel use of native gellan gum |
DE69710426T2 (de) | 1996-11-29 | 2002-10-02 | Hayashibara Biochem Lab | Verpackung für Inklusionsprodukt und Verfahren zu seiner Herstellung |
JP3635601B2 (ja) | 1996-12-02 | 2005-04-06 | 西川ゴム工業株式会社 | こんにゃくスポンジの製造方法 |
JP3049489B2 (ja) | 1996-12-19 | 2000-06-05 | 努 神倉 | 加熱処理済冷凍麺 |
JP4012595B2 (ja) | 1997-02-03 | 2007-11-21 | 好幸 坂野 | オリゴ糖組成物の製造方法 |
EP0868916A3 (en) | 1997-03-04 | 2004-09-15 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Reduction inhibitory agent for active-oxygen eliminating activity |
JPH1139450A (ja) | 1997-07-24 | 1999-02-12 | Mitsubishi Electric Corp | Icカード |
JPH1195405A (ja) | 1997-09-19 | 1999-04-09 | Sony Corp | フォトマスクの製造方法 |
CN1216781A (zh) | 1997-11-05 | 1999-05-19 | 中国科学院微生物研究所 | 一种发酵生产普鲁兰的新方法 |
CN1106448C (zh) | 1997-11-05 | 2003-04-23 | 中国科学院微生物研究所 | 从发酵液中提取普鲁兰的技术和工艺 |
JP4198774B2 (ja) | 1998-02-24 | 2008-12-17 | 日本曹達株式会社 | 農薬製剤 |
JP3697072B2 (ja) | 1998-07-31 | 2005-09-21 | 伊那食品工業株式会社 | 食物繊維スナック菓子及びその製造方法 |
JP2000080046A (ja) | 1998-09-03 | 2000-03-21 | Dai Ichi Seiyaku Co Ltd | 多臓器障害の予防・治療剤 |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
CA2520986C (en) | 1998-09-25 | 2007-11-13 | Warner-Lambert Company | Physiological compatible film |
EP1117736B2 (en) | 1998-09-30 | 2008-08-13 | Warner-Lambert Company LLC | Modified starch film compositions |
JP3672008B2 (ja) | 1999-01-20 | 2005-07-13 | シオノギクオリカプス株式会社 | 硬質カプセル及びその製造方法 |
DE19905801B4 (de) | 1999-02-12 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Herstellung folienförmiger Darreichungsformen |
CN1117453C (zh) | 1999-02-24 | 2003-08-06 | 中国科学院声学研究所 | 数字视频广播的数据广播系统 |
US20030104048A1 (en) * | 1999-02-26 | 2003-06-05 | Lipocine, Inc. | Pharmaceutical dosage forms for highly hydrophilic materials |
BR0008985B8 (pt) | 1999-03-15 | 2013-02-19 | processo para obtenÇço de um alimento expandido, composiÇço para uso no preparo de um alimento expandido, alimento expandido, e, uso de um amido de amilopectina nço cereal. | |
JP3422963B2 (ja) | 1999-03-15 | 2003-07-07 | 株式会社林原生物化学研究所 | ペプチドおよびその用途 |
WO2000057841A1 (fr) | 1999-03-31 | 2000-10-05 | Nof Corporation | Produits cosmetiques contenant des derives de polysaccharide-sterol |
JP2000294439A (ja) | 1999-04-05 | 2000-10-20 | Masaaki Suzuki | 樹脂結合型磁石の製造方法 |
JP2001048765A (ja) | 1999-05-28 | 2001-02-20 | Hayashibara Bijutsu Minto:Kk | 薫 香 |
JP2000348958A (ja) | 1999-06-03 | 2000-12-15 | Masaaki Suzuki | 樹脂結合型磁石の製造方法 |
EP1072633A1 (en) | 1999-07-22 | 2001-01-31 | Warner-Lambert Company | Pullulan film compositions |
EP1157691A1 (en) | 2000-05-16 | 2001-11-28 | Warner-Lambert Company | Pullulan film compositions with improved surface properties |
CN1125586C (zh) | 1999-09-23 | 2003-10-29 | 牛序堂 | 组合式复合保温被 |
JP4061000B2 (ja) | 1999-10-01 | 2008-03-12 | 太陽化学株式会社 | 麺類の品質改良剤と麺類の製造方法 |
JP2001162960A (ja) | 1999-12-06 | 2001-06-19 | Fuji Photo Film Co Ltd | 感熱性平版印刷版用原板 |
JP3653626B2 (ja) | 2000-01-13 | 2005-06-02 | 独立行政法人科学技術振興機構 | 有機・無機交互多重積層複合体 |
EP1256349A4 (en) | 2000-02-15 | 2005-11-16 | Hayashibara Biochem Lab | CELL ACTIVATOR |
KR100339715B1 (ko) | 2000-02-17 | 2002-06-05 | 이상재 | 고농도 당성분을 포함하는 식품가공 부산물을 이용한고분자 중합체 풀루란의 제조방법 |
KR100379674B1 (ko) * | 2000-03-06 | 2003-04-10 | 주식회사 서흥캅셀 | 펙틴과 글리세린의 배합용액을 이용한 셀룰로오스 캅셀 및그의 제조방법 |
JP2001250733A (ja) | 2000-03-06 | 2001-09-14 | Masaaki Suzuki | 樹脂結合型磁石の製造方法 |
CN1313498A (zh) | 2000-03-10 | 2001-09-19 | 四川德阳斯瑞得科技有限公司 | 高效节能烘干装置 |
JP4401533B2 (ja) | 2000-05-10 | 2010-01-20 | 株式会社春興社 | 成形薫香とその製造方法 |
JP3970540B2 (ja) | 2000-05-30 | 2007-09-05 | 高砂香料工業株式会社 | コーティング剤およびコーティング粉末 |
JP2002033231A (ja) | 2000-07-14 | 2002-01-31 | Masaaki Suzuki | 土壌改良型磁石の製造方法 |
JP3619433B2 (ja) | 2000-08-04 | 2005-02-09 | ハウス食品株式会社 | 糖衣固形食品及びその製造方法 |
JP4817088B2 (ja) | 2000-10-10 | 2011-11-16 | 株式会社林原生物化学研究所 | 塞栓材料 |
KR100877278B1 (ko) | 2000-11-16 | 2009-01-07 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | α-이소말토실 전이효소 활성을 가진 폴리펩티드 |
FR2817264B1 (fr) | 2000-11-29 | 2004-08-27 | Roquette Freres | Pullulan alpha-1,4-isomaltohydrolase |
US20020131990A1 (en) | 2000-11-30 | 2002-09-19 | Barkalow David G. | Pullulan free edible film compositions and methods of making the same |
WO2002046241A2 (en) | 2000-12-07 | 2002-06-13 | Ad 'zdravlje' Farmaceutsko - Hemijska Industrija, Centar Za Istrazivanje I Razvoj | Polynuclear complex fe(iii) with pullulan oligomers, process of its obtaining, and pharmaceutical preparations on the basis of the complex |
KR100414952B1 (ko) | 2001-02-09 | 2004-01-14 | (주)케이비피 | 식품가공 부산물인 간장박을 이용한 고분자 중합체풀루란의 제조방법 |
US6610810B2 (en) | 2001-03-13 | 2003-08-26 | Glyn Owen Phillips | Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere |
KR100458151B1 (ko) | 2001-05-14 | 2004-11-26 | 씨제이 주식회사 | 프락토실 트랜스퍼라제를 생산하는 신규 미생물 및 이를이용하여 프락토올리고당 및 네오프락토올리고당을생산하는 방법 |
CN1514716A (zh) | 2001-06-11 | 2004-07-21 | ��������ʲ��������ι�˾ | 呼吸保护微胶囊 |
DE10134560A1 (de) | 2001-07-16 | 2003-02-06 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Pfropfcopolymeren aus Stärke, tert-Alkylazocyanocarbonsäureester sowie Pfropfcopolymere und deren Verwendung |
JP4132767B2 (ja) | 2001-07-19 | 2008-08-13 | 株式会社林原生物化学研究所 | プルラン含有粉末とその製造方法並びに用途 |
PL194475B1 (pl) | 2001-07-19 | 2007-06-29 | Inst Biochemii I Biofizyki Pan | Gen plazmidowy, sposób otrzymywania tego genu, kodowany przez ten gen enzym amylolityczny, oraz jego zastosowanie |
US20030134409A1 (en) | 2001-08-03 | 2003-07-17 | Mallouk Thomas E. | Delivery vehicles for environmental remediants |
JP5089840B2 (ja) | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | ニコチン含有フィルム製剤 |
FR2831552B1 (fr) | 2001-10-30 | 2004-08-27 | Roquette Freres | Procede de preparation d'un milieu de fermentation autosuffisant |
JP2003134971A (ja) | 2001-10-31 | 2003-05-13 | Hayashibara Biochem Lab Inc | 擬似餌 |
JP4031232B2 (ja) | 2001-11-09 | 2008-01-09 | カプスゲル・ジャパン株式会社 | 新規カプセル |
US20050065030A1 (en) | 2001-11-20 | 2005-03-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Reduction inhibitory agent for active oxygen eliminating activity |
JP4397142B2 (ja) | 2001-11-20 | 2010-01-13 | 株式会社林原生物化学研究所 | 活性酸素消去能低減抑制剤 |
CN100408601C (zh) | 2001-12-07 | 2008-08-06 | 备前化成株士会社 | 糖原的物理化学生产方法及该方法获得的糖原 |
TW200307507A (en) | 2002-02-01 | 2003-12-16 | Hayashibara Biochem Lab Co Ltd | Process for producing fermented bread comprising rice flour as the main component |
JP4086516B2 (ja) | 2002-02-19 | 2008-05-14 | マリーンバイオ株式会社 | 炭酸カルシウム薄膜の製造方法、および光学素子の製造方法 |
JP5027375B2 (ja) | 2002-02-20 | 2012-09-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 改良製剤 |
JP3605399B2 (ja) | 2002-03-15 | 2004-12-22 | 日新化工株式会社 | 餅状加工食品及びその製造方法 |
US7179891B2 (en) | 2002-03-25 | 2007-02-20 | Tadanori Mayumi | Physiologically active complex |
CN1270780C (zh) | 2002-04-09 | 2006-08-23 | 株式会社林原生物化学研究所 | 栓塞材料 |
JP2003310295A (ja) | 2002-04-30 | 2003-11-05 | Invitrotech Co Ltd | 蛋白質の製造方法 |
AU2003236947A1 (en) | 2002-06-07 | 2003-12-22 | Ranbaxy Laboratories Limited | Modified release, multiple unit drug delivery systems |
US6916796B2 (en) | 2002-06-12 | 2005-07-12 | Abbott Laboratories | Use of pullulan as a slowly digested carbohydrate |
US20040013723A1 (en) | 2002-07-16 | 2004-01-22 | PARIKH Rita M. | Oral care capsules |
CN1681493A (zh) | 2002-07-19 | 2005-10-12 | 兰贝克赛实验室有限公司 | 掩味舒马曲坦片剂及其制备方法 |
GB0217382D0 (en) | 2002-07-26 | 2002-09-04 | Pfizer Ltd | Process for making orally consumable dosage forms |
US20040131661A1 (en) | 2002-07-26 | 2004-07-08 | Pfizer Inc. | Process for making orally consumable dosage forms |
AU2003253121A1 (en) | 2002-08-02 | 2004-02-25 | Ranbaxy Laboratories Limited | Storage stable tablets of fosinopril sodium |
EP1530458A1 (en) | 2002-08-14 | 2005-05-18 | Ranbaxy Laboratories, Ltd. | Extended release matrix tablets |
JP2004121292A (ja) | 2002-09-30 | 2004-04-22 | Hayashibara Biochem Lab Inc | 受容器電位誘発剤 |
JP4594732B2 (ja) | 2002-11-07 | 2010-12-08 | 株式会社林原生物化学研究所 | 水溶性フィルム |
WO2004056336A2 (en) | 2002-12-20 | 2004-07-08 | Ranbaxy Laboratories Limited | Controlled release, multiple unit drug delivery systems |
JP2004261132A (ja) | 2003-03-04 | 2004-09-24 | Hayashibara Biochem Lab Inc | プルラン分解酵素とその製造方法並びに用途 |
JP2004306534A (ja) | 2003-04-09 | 2004-11-04 | Toyo Ink Mfg Co Ltd | ガスバリア性積層体の製造方法 |
WO2004096182A1 (en) | 2003-04-30 | 2004-11-11 | Ranbaxy Laboratories Limited | Extended release matrix tablets of carvedilol |
TW200502004A (en) | 2003-05-02 | 2005-01-16 | Hayashibara Biochem Lab | Soft capsule film and soft capsule |
US20070099996A1 (en) | 2003-05-20 | 2007-05-03 | Shashikanth Isloor | Pharmaceutical compositions of acitretin |
WO2004112504A1 (ja) | 2003-06-17 | 2004-12-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | フィルム状甘味組成物 |
WO2005006874A1 (ja) | 2003-07-17 | 2005-01-27 | Sun Honest Co., Ltd. | 冷菓及びその製造方法 |
US20050019448A1 (en) | 2003-07-22 | 2005-01-27 | Kevin Engelhardt | Liquid flavoring dissolving strips and method of use thereof |
WO2005016315A1 (en) | 2003-08-14 | 2005-02-24 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of nateglinide and a high amount of a water-soluble filler |
WO2005020979A1 (en) | 2003-09-03 | 2005-03-10 | Ranbaxy Laboratories Limited | A process for the preparation of pharmaceutical compositions of nateglinide |
JP4601934B2 (ja) | 2003-10-06 | 2010-12-22 | ナガセ医薬品株式会社 | ユビデカレノン錠 |
JP4111513B2 (ja) | 2003-10-30 | 2008-07-02 | 株式会社竹中工務店 | 高強度コンクリート組成物 |
JP4111514B2 (ja) | 2003-10-30 | 2008-07-02 | 株式会社竹中工務店 | 超高強度コンクリート組成物 |
JP3922714B2 (ja) | 2003-10-30 | 2007-05-30 | 竹本油脂株式会社 | コンクリート用水硬性セメント組成物 |
US20070092625A1 (en) | 2003-11-19 | 2007-04-26 | Kyoko Ishimoto | Acidic protein food or drink and material thereof |
US20070219250A1 (en) | 2003-11-28 | 2007-09-20 | Romi Singh | Pharmaceutical Compositions of Nateglinide |
JP3605410B2 (ja) | 2003-12-22 | 2004-12-22 | 王子製紙株式会社 | 新規イソマルトオリゴ糖の製造法 |
DE102004002951A1 (de) | 2004-01-21 | 2005-08-11 | Wella Ag | Verfahren zur Herstellung haarfestigender Produkte in Folienform |
WO2005079751A2 (en) | 2004-01-23 | 2005-09-01 | Ranbaxy Laboratories Limited | Oral pharmaceutical compositions of candesartan cilexetil |
DE602005022553D1 (de) | 2004-02-06 | 2010-09-09 | Acquirer Systems Res Ltd | Testsystem |
JP4874651B2 (ja) * | 2004-02-17 | 2012-02-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 軟カプセル剤 |
WO2005082330A2 (en) | 2004-02-19 | 2005-09-09 | Ranbaxy Laboratories Limited | Co-precipitated amorphous cefditoren pivoxil and dosage forms comprising the same |
WO2005084433A1 (ja) | 2004-03-09 | 2005-09-15 | Foster Co., Ltd | 撒き餌、それに用いる水溶性容器の製造方法及び該製造方法に使用する金型 |
EP1580229A1 (en) * | 2004-03-22 | 2005-09-28 | Warner-Lambert Company Llc | Biopolymer compositons and products thereof |
JP2005302320A (ja) | 2004-04-06 | 2005-10-27 | Matsushita Electric Ind Co Ltd | 燃料電池の検査方法 |
JP4599550B2 (ja) | 2004-04-09 | 2010-12-15 | 国立大学法人 東京医科歯科大学 | ナノゲル工学によるハイブリッドゲルの調製とバイオマテリアル応用 |
CN100366294C (zh) | 2004-04-30 | 2008-02-06 | 量子高科(北京)研究院有限公司 | 一种口腔速溶制剂及其生产方法 |
CN1260569C (zh) | 2004-05-31 | 2006-06-21 | 广州伟仕科技有限公司 | 一种体外血型血清学实验检定使用的试剂盒 |
CN1264976C (zh) | 2004-05-31 | 2006-07-19 | 广州伟仕科技有限公司 | 一种提取木瓜凝乳蛋白酶的方法 |
JP2005341958A (ja) | 2004-06-07 | 2005-12-15 | Yuusu Kk | 機能性無洗米組成物 |
JP4605444B2 (ja) | 2004-07-15 | 2011-01-05 | ブラザー工業株式会社 | ミシンの糸掛け装置 |
JP4006421B2 (ja) | 2004-07-16 | 2007-11-14 | 北海道電力株式会社 | ホルムアルデヒド吸着剤及びその製造方法 |
WO2006018814A2 (en) | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Oral liquid suspensions of metaxalone |
JP2008513015A (ja) | 2004-09-17 | 2008-05-01 | エクセリクシス, インク. | Rac経路のモディファイヤーとしてのpik4caおよび使用方法 |
JP4784224B2 (ja) | 2004-09-24 | 2011-10-05 | 味の素株式会社 | 糖鎖転移方法および糖鎖転移酵素 |
JP4630963B2 (ja) | 2004-09-30 | 2011-02-09 | 株式会社大貴 | 粒状の排泄物処理材及び製造方法 |
CN1602716A (zh) | 2004-11-16 | 2005-04-06 | 江南大学 | 一种利用液体普鲁兰直接生产爽口片的方法 |
CN100366727C (zh) | 2004-11-16 | 2008-02-06 | 江南大学 | 一种生产普鲁兰的菌株与利用该菌株生产普鲁兰的方法 |
JP4550555B2 (ja) | 2004-11-17 | 2010-09-22 | 国立大学法人 東京医科歯科大学 | 量子ドット(Qdot)−ナノゲル複合体の調製 |
KR100508434B1 (ko) | 2004-12-22 | 2005-08-17 | 충청북도 | 마늘 추출액을 함유하는 가식성 항균필름의 제조방법 |
CN1317381C (zh) | 2004-12-23 | 2007-05-23 | 李世杰 | 短梗霉多糖薄膜及用于菌种保藏的方法 |
US20060147542A1 (en) | 2004-12-24 | 2006-07-06 | Tadao Ono | Solid preparation containing reduced coenzyme Q10 and method for producing the same |
WO2006070578A1 (ja) | 2004-12-28 | 2006-07-06 | Qualicaps Co., Ltd. | 硬カプセルのバンドシール |
US7856989B2 (en) | 2004-12-30 | 2010-12-28 | Philip Morris Usa Inc. | Electrostatically produced fast dissolving fibers |
CN1289532C (zh) | 2005-01-11 | 2006-12-13 | 苏理 | 普鲁兰糖的后提取生产工艺 |
CN1315873C (zh) | 2005-01-11 | 2007-05-16 | 苏理 | 普鲁兰糖的溶剂提取生产工艺 |
CN1680571A (zh) | 2005-01-17 | 2005-10-12 | 天津科贝思生物试剂有限公司 | 麦芽三糖的制备方法 |
JP4766653B2 (ja) | 2005-01-28 | 2011-09-07 | 株式会社林原生物化学研究所 | 眼科用医薬組成物 |
JPWO2006082842A1 (ja) | 2005-02-03 | 2008-08-07 | クオリカプス株式会社 | 溶解性が改善された硬カプセル |
JP2005137935A (ja) | 2005-02-14 | 2005-06-02 | Shionogi Qualicaps Co Ltd | 硬質カプセル及びその製造方法 |
CN1313498C (zh) | 2005-02-21 | 2007-05-02 | 汕头市富味制果厂有限公司 | 一种生产普鲁兰的方法 |
JP4568819B2 (ja) | 2005-03-10 | 2010-10-27 | 国立大学法人大阪大学 | 金属ナノクラスターの製造方法 |
JP4893980B2 (ja) | 2005-04-08 | 2012-03-07 | 株式会社林原生物化学研究所 | 分岐澱粉とその製造方法並びに用途 |
WO2006118137A1 (ja) | 2005-04-26 | 2006-11-09 | Dainippon Sumitomo Pharma Co., Ltd. | ビグアナイド系薬物を含有する粒状製剤 |
CN1696302A (zh) | 2005-05-13 | 2005-11-16 | 天津市工业微生物研究所 | 一种生产普鲁兰多糖的发酵方法 |
JP4474336B2 (ja) | 2005-06-28 | 2010-06-02 | 株式会社林原生物化学研究所 | 口腔チタンインプラント材とその製造方法 |
WO2007011222A2 (en) | 2005-07-15 | 2007-01-25 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Cholesterol-lowering food additive |
CN1290505C (zh) | 2005-07-18 | 2006-12-20 | 天津大学 | 载5-氟尿嘧啶药物的pH敏感可控释放纳米粒及制备方法 |
US20070042970A1 (en) | 2005-08-22 | 2007-02-22 | Chemical Soft R&D Inc. | Folate-modified cholesterol-bearing pullulan as a drug carrier |
JP4824501B2 (ja) | 2005-08-30 | 2011-11-30 | 株式会社箔一 | 金属箔被覆粒状食品の製造方法 |
WO2007095977A1 (en) | 2005-10-14 | 2007-08-30 | Unilever N.V. | Food product and process for preparing it |
CN1317035C (zh) | 2005-10-24 | 2007-05-23 | 天津大学 | 基于酰肼基的微粒表面多重生物功能因子组装方法 |
CN101326658B (zh) | 2005-12-06 | 2010-09-29 | Lg化学株式会社 | 具有形态梯度的有机/无机复合隔膜、其制造方法和含该隔膜的电化学装置 |
KR100739022B1 (ko) | 2005-12-12 | 2007-07-12 | 동아대학교 산학협력단 | 설탕액을 이용한 풀루란의 연속 생산 방법 |
GB2435510A (en) | 2006-02-23 | 2007-08-29 | Mologic Ltd | Enzyme detection product and methods |
JP5240536B2 (ja) | 2006-03-06 | 2013-07-17 | 芳一 飛永 | 複合糖材成形品 |
PT1998762E (pt) | 2006-03-16 | 2010-11-30 | Novartis Ag | Forma farmacêutica sólida contendo um agente activo de sabor mascarado |
US20070258941A1 (en) | 2006-05-02 | 2007-11-08 | Pfister Brian E | Methods and compositions for remediation of disc herniation by modifying structure |
MX350380B (es) | 2006-05-09 | 2017-09-05 | SpecGx LLC | Formas de dosificacion solida de liberacion modificada en el orden de cero. |
JP5072265B2 (ja) | 2006-05-30 | 2012-11-14 | 株式会社林原 | プルラン誘導体とその用途 |
US20070292481A1 (en) | 2006-06-16 | 2007-12-20 | Hoffman Andrew J | Packaging of Food Products with Pullulan Films |
US20090274636A1 (en) | 2006-06-28 | 2009-11-05 | Shigeo Shinohara | Tooth enamel dissolution inhibitor |
JP2008011807A (ja) | 2006-07-07 | 2008-01-24 | Ryoichi Yamakawa | フローズンヨーグルトおよび洋菓子の製造方法 |
US20080038432A1 (en) | 2006-08-14 | 2008-02-14 | Hoffman Andrew J | Food Additive Comprising at Least One Fiber Source and at Least One Monosaccharide or Sugar Alcohol |
JP5002792B2 (ja) | 2006-08-28 | 2012-08-15 | リグナイト株式会社 | 多糖類変性フェノール樹脂、多糖類変性フェノール樹脂の製造方法、レジンコーテッドサンド、多糖類変性フェノール樹脂炭化材料、導電性樹脂組成物、電極用炭素材料、二次電池用電極、電気二重層キャパシタ分極性電極 |
WO2008047846A1 (fr) | 2006-10-17 | 2008-04-24 | San-Ei Gen F.F.I., Inc. | Agent améliorant la qualité pour du riz cuit et son application |
US20100093875A1 (en) | 2006-10-25 | 2010-04-15 | Dainippon Sumitomo Pharma Co., Ltd. | Granular preparation prevented from caking |
CN100465191C (zh) | 2006-11-03 | 2009-03-04 | 天津市工业微生物研究所 | 普鲁兰多糖的干燥方法 |
BRPI0719395C1 (pt) | 2006-12-07 | 2021-05-25 | Daiichi Sankyo Co Ltd | tablete revestido de filme |
JP2008162966A (ja) | 2006-12-28 | 2008-07-17 | Taisho Pharm Ind Ltd | プランルカスト水和物の付着凝集性を低減する方法 |
JP5591449B2 (ja) | 2007-02-02 | 2014-09-17 | 株式会社林原 | 毛髪処理剤用の酸化剤含有組成物 |
US8021863B2 (en) | 2007-02-19 | 2011-09-20 | Novozymes A/S | Polypeptides with starch debranching activity |
JP5140804B2 (ja) | 2007-02-27 | 2013-02-13 | 国立大学法人広島大学 | 生体再生カプセル |
EP2135883B1 (en) | 2007-03-30 | 2015-06-10 | Dainichiseika Color & Chemicals Mfg. Co., Ltd. | Process for producing silylated pullulan and cosmetic preparation |
CA2682752C (en) | 2007-04-05 | 2015-07-07 | University Of Kansas | Rapidly dissolving pharmaceutical compositions comprising pullulan |
US8900629B2 (en) | 2007-04-05 | 2014-12-02 | University Of Kansas | Rapidly dissolving pharmaceutical compositions comprising pullulan |
CN100571781C (zh) | 2007-04-20 | 2009-12-23 | 中国医学科学院生物医学工程研究所 | 生物素化普鲁兰多糖纳米微粒及其制备方法 |
CN100594938C (zh) | 2007-04-20 | 2010-03-24 | 中国医学科学院生物医学工程研究所 | 具有肿瘤靶向作用的普鲁兰多糖载体材料 |
JP2008266458A (ja) | 2007-04-20 | 2008-11-06 | Sanai Seiyaku Kk | キトサン混合物、並びにキトサン及びキチン混合物 |
WO2008136331A1 (ja) | 2007-04-26 | 2008-11-13 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | 分岐α-グルカン及びこれを生成するα-グルコシル転移酵素とそれらの製造方法並びに用途 |
US20080274187A1 (en) | 2007-05-02 | 2008-11-06 | J.C. Bright M. Ltd. | Hard capsule composition and method of use |
WO2008137832A1 (en) | 2007-05-07 | 2008-11-13 | Tate & Lyle Ingredients Americas, Inc. | Edible pullulan films containing dairy product |
AU2008202283B2 (en) | 2007-06-01 | 2011-01-20 | Kyong-Min Shin | Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith |
CN101069677A (zh) | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | 普鲁兰多糖空心硬胶囊及其制造方法 |
JP2009013107A (ja) | 2007-07-04 | 2009-01-22 | Shiseido Co Ltd | 皮膚損傷修復用組成物 |
CN101096236B (zh) | 2007-07-05 | 2010-05-19 | 江南大学 | 一种可食用的方便面辅料包装袋的制备方法 |
CN101088879A (zh) | 2007-07-11 | 2007-12-19 | 李世杰 | 可以食用的短梗霉多糖薄膜包装袋 |
CN101100687A (zh) | 2007-07-25 | 2008-01-09 | 南开大学 | 同时获得副产物普鲁兰的β-聚苹果酸的制备方法 |
JP5795475B2 (ja) | 2007-07-25 | 2015-10-14 | エルジー・ケム・リミテッド | 電気化学素子及びその製造方法 |
JP2009039064A (ja) | 2007-08-10 | 2009-02-26 | Uha Mikakuto Co Ltd | ソフトキャンディ及びその製造方法 |
KR100937489B1 (ko) | 2007-10-10 | 2010-01-19 | 신달하 | 비지 발효물을 이용한 풀루란의 제조방법 |
WO2009050646A2 (en) | 2007-10-19 | 2009-04-23 | Pfizer Products Inc. | Multi-compartmented container |
JP5442243B2 (ja) | 2007-12-11 | 2014-03-12 | 株式会社林原 | 腎障害抑制剤 |
JP4971298B2 (ja) | 2008-01-11 | 2012-07-11 | ユニメディカル株式会社 | 腸溶性・徐放性ソフトカプセル及びその製造方法 |
CN101215592B (zh) | 2008-01-15 | 2011-08-17 | 天津市工业微生物研究所 | 生产普鲁兰多糖的发酵方法 |
JP2008133186A (ja) | 2008-02-04 | 2008-06-12 | Hiroshima Univ | 無機微粒子の作製方法 |
CN101229379A (zh) | 2008-02-19 | 2008-07-30 | 华东理工大学 | 基于普鲁蓝多糖的肠溶制剂辅料 |
WO2009118589A2 (en) | 2008-03-24 | 2009-10-01 | Wockhardt Research Centre | Orally disintegrating compositions of rhein or diacerein |
JP5020871B2 (ja) | 2008-03-25 | 2012-09-05 | 富士フイルム株式会社 | 平版印刷版の製造方法 |
JP5264427B2 (ja) | 2008-03-25 | 2013-08-14 | 富士フイルム株式会社 | 平版印刷版の作製方法 |
JP2009233170A (ja) | 2008-03-27 | 2009-10-15 | Fujifilm Corp | 高アスペクト比構造シートの製造方法 |
JP4999750B2 (ja) | 2008-03-28 | 2012-08-15 | タカノフーズ株式会社 | 日持ち納豆およびその製造方法 |
JP5572086B2 (ja) | 2008-04-02 | 2014-08-13 | 株式会社林原 | ソフトカプセル皮膜及びソフトカプセル |
EP2108677A1 (de) | 2008-04-10 | 2009-10-14 | Swiss Caps Rechte und Lizenzen AG | Thermoplastische Stärkemassen |
CN101254309A (zh) | 2008-04-11 | 2008-09-03 | 中国医学科学院生物医学工程研究所 | 叶酸受体介导靶向乙酰普鲁兰多糖纳米粒及制备方法 |
CN101283774B (zh) | 2008-04-28 | 2012-06-06 | 广东富味制果厂有限公司 | 一种微胶囊香精及其制备方法 |
WO2009133464A2 (en) | 2008-04-30 | 2009-11-05 | Danisco A/S | Oxidation process |
CN102026611B (zh) | 2008-05-12 | 2015-03-11 | 比利时胶囊公司 | 具有排气孔的改良胶囊 |
CN101579326B (zh) | 2008-05-13 | 2012-07-18 | 金斐嘉 | 普鲁兰多糖空心硬胶囊及其制备方法 |
RS20080223A (en) | 2008-05-16 | 2011-04-30 | Goran NIKOLIĆ | SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROPERTIES OF COPPER (II) BIOACTIVE COMPLEXES WITH PULULAN AND ITS DERIVATIVES |
CN101279096B (zh) | 2008-05-29 | 2011-04-06 | 吕兴文 | 一种普鲁兰多糖Vc包衣组合物 |
KR100993577B1 (ko) | 2008-06-19 | 2010-11-10 | 한국생명공학연구원 | 신균주 아우레오바시디움 풀루란스 np-1221 kctc11265bp 및 이를 이용하여 세포외 분비형 베타-글루칸을생산하는 방법 |
JP2010053122A (ja) | 2008-07-31 | 2010-03-11 | Hayashibara Biochem Lab Inc | 脂質合成阻害剤 |
US20110177137A1 (en) | 2008-09-15 | 2011-07-21 | Intas Pharmaceuticals Limited | Novel dosage form of paliperidone and process for preparing the same |
KR101136738B1 (ko) | 2008-10-02 | 2012-04-19 | 주식회사 라파스 | 송풍에 의한 솔리드 마이크로구조체의 제조방법 및 이로부터 제조된 솔리드 마이크로구조체 |
FR2937974B1 (fr) | 2008-10-30 | 2013-01-11 | Univ Bordeaux 1 | Copolymeres a blocs a base de polysaccharide et de polypeptide, les vesicules constituees de ces copolymeres et leur utilisation |
JP5344558B2 (ja) | 2008-10-31 | 2013-11-20 | 国立大学法人 東京医科歯科大学 | カチオン性ナノゲルを用いる粘膜ワクチン |
CN101760456A (zh) | 2008-12-11 | 2010-06-30 | 吴菁 | 一种新型高分子材料茁霉多糖的制备方法 |
CN101416930B (zh) | 2008-12-22 | 2011-03-16 | 山东省生物药物研究院 | 一种含有普鲁兰多糖的面膜 |
CN101487034B (zh) | 2009-02-23 | 2013-06-05 | 中国科学院过程工程研究所 | β-聚苹果酸及其盐的制备方法 |
KR101086055B1 (ko) | 2009-03-06 | 2011-11-22 | 가톨릭대학교 산학협력단 | 온도 민감성 풀루란-락타이드 공중합체, 이로부터 형성된 나노입자, 및 그 제조방법 |
JP5347639B2 (ja) | 2009-03-27 | 2013-11-20 | ユーハ味覚糖株式会社 | 餅様の食感と風味を有するソフトキャンディ及びその製造方法 |
KR101059285B1 (ko) | 2009-05-07 | 2011-08-24 | 가톨릭대학교 산학협력단 | 가돌리늄 착물, 그 제조방법, 및 그것을 포함하는 mri 조영제 |
CN101555507B (zh) | 2009-05-18 | 2012-03-28 | 杨凌壹之农微生物工程技术研究院有限公司 | 一种由普鲁兰糖制备高纯度麦芽三糖的方法 |
CN101560528A (zh) | 2009-05-21 | 2009-10-21 | 天津科技大学 | 一种酶法去除普鲁兰多糖提取获得β-聚苹果酸的方法 |
JP2010275440A (ja) | 2009-05-29 | 2010-12-09 | Murakami Corp | 親水性回復剤および親水性回復方法 |
CN101570770A (zh) | 2009-05-31 | 2009-11-04 | 江南大学 | 一种麦芽三糖基-β-环糊精的酶法制备方法 |
CN101942493A (zh) | 2009-07-03 | 2011-01-12 | 山东省生物药物研究院 | 普鲁兰糖无色素生产方法 |
CN101653171A (zh) | 2009-09-15 | 2010-02-24 | 盐城工学院 | 牛初乳鲜奶生产中应用的一种稳定剂 |
CN101669670B (zh) | 2009-09-22 | 2013-02-27 | 广州优锐生物科技有限公司 | 一种含有普鲁兰多糖的防腐保鲜剂及其制作方法 |
PL3435442T3 (pl) | 2009-09-29 | 2023-09-11 | Lg Energy Solution, Ltd. | Sposób wytwarzania separatora |
KR101198634B1 (ko) | 2009-10-07 | 2012-11-07 | 한국교통대학교산학협력단 | 충치예방용 천연 가식성 항균필름 조성물 및 그 제조방법 |
JP5090431B2 (ja) | 2009-12-09 | 2012-12-05 | 俊彦 松尾 | 受容器電位誘発剤のための有機色素化合物のスクリーニング方法 |
US20110139164A1 (en) | 2009-12-15 | 2011-06-16 | R. J. Reynolds Tobacco Company | Tobacco Product And Method For Manufacture |
CN101755991A (zh) | 2010-01-13 | 2010-06-30 | 天津实发中科百奥工业生物技术有限公司 | 含普鲁兰多糖的冷食产品的生产方法 |
CN101731410A (zh) | 2010-01-13 | 2010-06-16 | 天津实发中科百奥工业生物技术有限公司 | 含普鲁兰多糖的巧克力及其制品的生产工艺 |
KR20110089044A (ko) | 2010-01-29 | 2011-08-04 | (주)한국바이오솔루션 | 다양한 분자량을 가지는 풀루란의 제조방법 |
JP5751758B2 (ja) | 2010-03-09 | 2015-07-22 | 株式会社バイオテックジャパン | 香辛料等の添加米と添加米飯の製造方法 |
JP5694678B2 (ja) | 2010-03-15 | 2015-04-01 | 株式会社大貴 | 粒状の排泄物処理材及び製造方法 |
CN101839849A (zh) | 2010-03-29 | 2010-09-22 | 王一鸣 | 一种直链淀粉检测仪及其直链淀粉的检测方法 |
JP2011207847A (ja) | 2010-03-30 | 2011-10-20 | Nitto Denko Corp | フィルム状製剤及びその製造方法 |
EP2382969A1 (en) | 2010-04-30 | 2011-11-02 | Sanovel Ilac Sanayi ve Ticaret A.S. | Multicoated Aliskiren formulations |
CN101831000A (zh) | 2010-05-21 | 2010-09-15 | 中国医学科学院生物医学工程研究所 | 乙酰普鲁兰多糖叶酸偶联物的纯化及其纳米粒子的制备方法 |
US20110292566A1 (en) | 2010-05-26 | 2011-12-01 | General Electric Company | Cyanoresin polymer for dielectric film, process of making and associated article |
CN102258484B (zh) | 2010-05-26 | 2017-11-03 | 董玲 | 一种含有中药挥发性成分的冻干赋形制剂 |
JP2012017326A (ja) | 2010-06-11 | 2012-01-26 | Takashi Fujii | 難溶物を含有するカプセルとその製造方法 |
ES2897489T3 (es) | 2010-06-17 | 2022-03-01 | Hayashibara Co | Método de producción de polvo que contiene pululano |
CN101836678A (zh) | 2010-06-21 | 2010-09-22 | 天津科技大学 | 一种可常温保存的再制干酪及其制备方法 |
JP5558936B2 (ja) | 2010-06-29 | 2014-07-23 | 富士フイルム株式会社 | 積層素子の製造方法及び積層素子 |
JP2012016309A (ja) | 2010-07-08 | 2012-01-26 | Hayashibara Biochem Lab Inc | マルトトリオース生成アミラーゼとその製造方法並びに用途 |
WO2012021710A1 (en) | 2010-08-11 | 2012-02-16 | Tic Gums, Inc. | Pullulan replacements for films and coatings |
CN101974543B (zh) | 2010-08-18 | 2012-05-23 | 江南大学 | 一种来源于芽孢杆菌的胞外普鲁兰酶编码基因及其应用 |
CN103179869B (zh) | 2010-08-20 | 2016-05-18 | 日本烟草产业株式会社 | 非加热型香烟香精抽吸器 |
JP5826473B2 (ja) | 2010-09-16 | 2015-12-02 | 協和発酵バイオ株式会社 | 直打用高単位グルコサミン顆粒 |
CN102010513B (zh) | 2010-10-12 | 2013-01-23 | 中南大学 | 一种稳定的多糖修饰明胶纳米粒子及其制备方法和应用 |
CN101988036B (zh) | 2010-11-01 | 2013-04-03 | 吉林农业大学 | 出芽短梗霉菌株和其制备方法及用于生产无色素茁霉多糖 |
CN102027999A (zh) | 2010-11-18 | 2011-04-27 | 黑龙江大学 | 一种含有普鲁兰多糖的苏云金芽孢杆菌可湿性粉剂及其制备方法 |
CN102010526A (zh) | 2010-11-22 | 2011-04-13 | 福建农林大学 | 魔芋葡甘聚糖可食性餐具及其制备方法 |
KR101214510B1 (ko) | 2010-12-08 | 2013-01-03 | 농업회사법인 산나물박물관 주식회사 | 곤드레 나물 블록의 제조방법 |
CN102552191B (zh) | 2010-12-31 | 2015-09-30 | 量子高科(北京)研究院有限公司 | 一种5-ht受体激动剂口腔崩解片及其制备方法 |
PT2663294E (pt) | 2011-01-11 | 2016-01-25 | Capsugel Belgium Nv | Novas cápsulas duras contendo pululano |
JP5886641B2 (ja) | 2011-01-28 | 2016-03-16 | 三栄源エフ・エフ・アイ株式会社 | 多糖類の精製方法 |
EA201500604A1 (ru) | 2011-02-11 | 2015-09-30 | СиТиСи БАЙО, ИНК. | Пленочная лекарственная форма, содержащая свободное основание силденафила, и способ ее получения |
WO2012121202A1 (ja) | 2011-03-04 | 2012-09-13 | 株式会社クレハ | 錠剤型の経口投与用組成物及びその製造方法 |
CN103608461B (zh) | 2011-03-09 | 2016-08-03 | 诺维信公司 | 增加多肽的纤维素分解增强活性的方法 |
KR20140020289A (ko) | 2011-03-24 | 2014-02-18 | 오츠카 세이야쿠 가부시키가이샤 | 레바미피드를 함유하는 구강 내 질환 치료용 의약 조성물 |
CN102145173B (zh) | 2011-03-31 | 2013-10-30 | 中国医学科学院生物医学工程研究所 | 人血清白蛋白复合的疏水改性普鲁兰多糖纳米粒子及制备方法 |
EP2708139B1 (en) | 2011-05-13 | 2019-03-20 | Lotte Co., Ltd. | Soft candy and production method for soft candy |
JP5427839B2 (ja) | 2011-06-22 | 2014-02-26 | 株式会社ファーストラナーズ | 加工食品素材並びにそれを用いた食品及びその食品の製造方法 |
KR20130009553A (ko) | 2011-07-15 | 2013-01-23 | 한미약품 주식회사 | 몬테루카스트 또는 이의 약학적으로 허용가능한 염 및 레보세티리진 또는 이의 약학적으로 허용가능한 염을 함유하는 캡슐 제제 |
WO2013012292A2 (ko) | 2011-07-20 | 2013-01-24 | 주식회사 엘지화학 | 세퍼레이터, 그 제조방법 및 이를 구비한 전기화학소자 |
CN102552721A (zh) | 2011-07-26 | 2012-07-11 | 连云港康力特药业有限公司 | 一种解决维c银翘片包衣片变色的方法 |
US8951996B2 (en) | 2011-07-28 | 2015-02-10 | Lipocine Inc. | 17-hydroxyprogesterone ester-containing oral compositions and related methods |
CN102432921B (zh) | 2011-09-16 | 2013-04-17 | 中国烟草总公司郑州烟草研究院 | 普鲁兰多糖添加剂及其在卷烟中的应用 |
CN102499451B (zh) | 2011-10-11 | 2013-05-08 | 中国烟草总公司郑州烟草研究院 | 添加沙棘制剂的爽口片型无烟气烟草制品 |
WO2013085021A1 (ja) | 2011-12-09 | 2013-06-13 | 株式会社林原 | 抗体産生増強用の組成物 |
CN102531773B (zh) | 2011-12-13 | 2014-03-19 | 福建超大现代种业有限公司 | 一种含过氧化钛的增氧型种子处理剂的制造方法 |
CN102499910B (zh) | 2011-12-15 | 2013-06-05 | 山西吉呈生物技术有限公司 | 一种基于普鲁兰多糖的硬壳胶囊 |
CN102492630A (zh) | 2011-12-16 | 2012-06-13 | 天津北洋百川生物技术有限公司 | 生产黑色素的诱变菌株出芽短梗霉及其培养方法和应用 |
CN102492740B (zh) | 2011-12-16 | 2013-08-07 | 天津北洋百川生物技术有限公司 | 一种出芽短梗霉联产聚苹果酸和普鲁兰多糖的方法 |
CN102603912B (zh) | 2012-01-09 | 2014-01-01 | 四川大学 | 天然普鲁兰多糖纳米药物载体及其制备方法 |
KR20140122650A (ko) | 2012-02-24 | 2014-10-20 | 퀀텀 하이테크 (베이징) 리서치 인스티튜트 | 경구 분해 정제 및 이의 제조 방법 |
CN102600493B (zh) | 2012-03-06 | 2013-12-18 | 四川大学 | 天然普鲁兰多糖水凝胶伤口敷料及其制备方法 |
WO2013146669A1 (ja) | 2012-03-28 | 2013-10-03 | 国立大学法人岡山大学 | リン酸化多糖の製造方法 |
KR20140143216A (ko) | 2012-04-03 | 2014-12-15 | 테라젝트, 인코포레이티드 | 백신의 구강점막 전달용인 용해성 미세바늘 어레이 |
US20130288932A1 (en) | 2012-04-27 | 2013-10-31 | Halliburton Energy Services, Inc. | Methods of cryodesiccating a broth comprising a biopolymer of an exopolysaccharide |
CN102626279A (zh) | 2012-04-28 | 2012-08-08 | 福建农林大学 | 一次性筷子及其制备方法 |
CN102766219B (zh) | 2012-05-23 | 2014-08-13 | 山东齐都药业有限公司 | 一种降低中分子量羟乙基淀粉双取代比例的制备工艺 |
CN102670563A (zh) | 2012-06-05 | 2012-09-19 | 江南大学 | 一种无明胶软胶囊的制备方法 |
CN103508075A (zh) | 2012-06-28 | 2014-01-15 | 浙江新安化工集团股份有限公司 | 一种环保型百草枯制剂包装法及使用方法 |
CN102783713B (zh) | 2012-08-16 | 2014-04-16 | 贵州中烟工业有限责任公司 | 一种酒香型胶丸滤嘴及其制备工艺 |
CN102875742B (zh) | 2012-09-05 | 2014-08-06 | 喻小琦 | 一种支链淀粉为骨架的高支化度丙烯酰胺接枝共聚物的制造方法 |
US20150209275A1 (en) | 2012-09-11 | 2015-07-30 | University Of The Witwatersrand, Johannesburg | Fast Dissolving Ocular Insert |
JP6309895B2 (ja) | 2012-09-27 | 2018-04-11 | 株式会社三和化学研究所 | アナグリプチン含有製剤 |
CN102994395B (zh) | 2012-10-15 | 2014-07-02 | 苏州大学 | 一株出芽短梗霉及其应用 |
GB2507760B (en) | 2012-11-08 | 2015-07-08 | Inst Of Food Res | Methods |
CN103798253A (zh) | 2012-11-08 | 2014-05-21 | 山东福瑞达生物科技有限公司 | 一种种子处理剂 |
CN103805650B (zh) | 2012-11-09 | 2016-08-17 | 山东福瑞达生物科技有限公司 | 一种无色素普鲁兰多糖的发酵生产方法 |
CN103805651B (zh) | 2012-11-09 | 2016-04-06 | 山东福瑞达生物科技有限公司 | 一种基于细胞代谢调控策略的普鲁兰多糖生产方法 |
CN103015175B (zh) | 2012-12-06 | 2016-05-25 | 张家口卷烟厂有限责任公司 | 普鲁兰多糖改性烟用聚丙烯纤维及其制备方法 |
CN103882076A (zh) | 2012-12-20 | 2014-06-25 | 山东福瑞达生物科技有限公司 | 一种高分子量普鲁兰多糖的发酵生产方法 |
CN102964849B (zh) | 2012-12-24 | 2015-10-21 | 青岛文创科技有限公司 | 一种鱼鳞胶原蛋白/普鲁兰多糖复合型可食用膜及其制备方法 |
CN103030978B (zh) | 2012-12-24 | 2015-07-08 | 青岛文创科技有限公司 | 一种鱼鳞胶原蛋白/普鲁兰多糖复合型可食用膜及其制备方法 |
US20140187538A1 (en) | 2012-12-28 | 2014-07-03 | Dr. Reddy's Laboratories Ltd. | Lorcaserin hydrochloride |
CN103088085B (zh) | 2012-12-31 | 2014-08-27 | 天津北洋百川生物技术有限公司 | 淀粉废水及麦芽根制备培养基及发酵普鲁兰多糖的方法 |
CN103172757B (zh) | 2012-12-31 | 2015-01-14 | 天津北洋百川生物技术有限公司 | 一种普鲁兰多糖的提取工艺 |
CN103243135A (zh) | 2012-12-31 | 2013-08-14 | 天津北洋百川生物技术有限公司 | 生产普鲁兰多糖的新培养基及发酵生产普鲁兰多糖的方法 |
CN103060204B (zh) | 2012-12-31 | 2014-02-26 | 天津北洋百川生物技术有限公司 | 大量生产普鲁兰多糖的诱变菌株及其培养方法 |
CN103163128B (zh) | 2013-03-13 | 2015-07-22 | 重庆大学 | 一种高粱中支链淀粉和直链淀粉含量的测定方法 |
EP2990072B1 (en) | 2013-04-26 | 2019-06-12 | Toppan Printing Co., Ltd. | Production method for acicular body |
CN103305569B (zh) | 2013-05-10 | 2014-09-10 | 天津科技大学 | 出芽短梗霉ay82利用木糖生产普鲁兰糖的方法 |
CN103255067B (zh) | 2013-05-10 | 2015-01-07 | 天津科技大学 | 一株利用木糖高产普鲁兰糖的出芽短梗霉及其应用 |
JP6453319B2 (ja) | 2013-06-04 | 2019-01-16 | モノソル リミテッド ライアビリティ カンパニー | 水溶性フィルムシール溶液、関連する方法、および関連する物品 |
TR201307748A2 (tr) | 2013-06-27 | 2014-09-22 | Ege Ueniversitesi | Tırnak mantarının topikal tedavisi için formülasyon geliştirilmesi. |
CN103351629B (zh) | 2013-07-25 | 2015-11-18 | 中国烟草总公司郑州烟草研究院 | 一种烟叶蛋白/普鲁兰多糖可食用复合膜及其制备方法 |
CN103451108B (zh) | 2013-08-06 | 2015-01-07 | 红云红河烟草(集团)有限责任公司 | 一种出芽短梗霉菌of-01菌株及用它制备烟草内源性衍生香料的方法 |
CN103409480B (zh) | 2013-08-22 | 2014-11-05 | 天津北洋百川生物技术有限公司 | 一种生产不同分子量普鲁兰多糖的方法 |
JP6182023B2 (ja) | 2013-08-30 | 2017-08-16 | アサヒグループ食品株式会社 | 酸化マグネシウム含有錠剤及びその製造方法 |
CN103416694B (zh) | 2013-09-03 | 2015-02-11 | 湖南农业大学 | 一种利用复合酶直接酶解葛根原料生产即食葛根粉的方法 |
CN103503983A (zh) | 2013-09-30 | 2014-01-15 | 天津大学 | 用普鲁兰多糖处理防治黄冠梨鸡爪病的方法 |
CN103806275B (zh) | 2013-10-11 | 2016-02-17 | 天津市中科健新材料技术有限公司 | 一种用于卫生巾面层的芦荟护肤无纺布制备方法 |
CN103570842A (zh) | 2013-11-07 | 2014-02-12 | 镇江东方生物工程设备技术有限责任公司 | 一种普鲁兰多糖的提取方法 |
CN103642086B (zh) | 2013-11-07 | 2016-01-06 | 青岛文创科技有限公司 | 一种氧化普鲁兰多糖-醇溶蛋白改性天然乳胶的方法 |
CN103626885A (zh) | 2013-11-14 | 2014-03-12 | 江南大学 | 一种普鲁兰多糖的清洁生产方法 |
CN103724709A (zh) | 2013-11-26 | 2014-04-16 | 青岛文创科技有限公司 | 一种氧化普鲁兰多糖-丝胶复合物改性天然乳胶的方法 |
CN104694404A (zh) | 2013-12-09 | 2015-06-10 | 青岛根源生物技术集团有限公司 | 一种微生物生产普鲁兰多糖的方法 |
CN105849246B (zh) | 2013-12-20 | 2019-08-16 | 丽而泽有限公司 | 凝胶状清洁剂的制造方法 |
CN103636743B (zh) | 2013-12-25 | 2016-04-27 | 长沙理工大学 | 一种带壳鲜莲的冷藏保鲜方法 |
CN103695476B (zh) | 2013-12-25 | 2016-03-02 | 天津北洋百川生物技术有限公司 | 乙醇-普鲁兰多糖偶联发酵方法 |
CN103695500A (zh) | 2013-12-27 | 2014-04-02 | 天津北洋百川生物技术有限公司 | 一种提高普鲁兰多糖产量的方法 |
CN103740785A (zh) | 2013-12-28 | 2014-04-23 | 天津北洋百川生物技术有限公司 | 高密度发酵生产普鲁兰多糖的方法 |
CN103993042B (zh) | 2014-01-07 | 2016-08-24 | 天津科技大学 | 一种木质纤维素类物质联产生物乙醇和普鲁兰糖的方法 |
JP6495619B2 (ja) | 2014-02-26 | 2019-04-03 | クラシエフーズ株式会社 | 油脂性成形菓子及びその製法 |
CN103789363B (zh) | 2014-02-28 | 2016-02-10 | 西南大学 | 提高聚苹果酸产量的方法 |
CN103881927B (zh) | 2014-03-04 | 2017-08-04 | 江西省科学院微生物研究所 | 一种高产无色素普鲁兰多糖的茁芽短梗霉及其培养和制备普鲁兰多糖的方法 |
WO2015133439A1 (ja) | 2014-03-07 | 2015-09-11 | 日本全薬工業株式会社 | プルランゲルならびにその製造方法および利用 |
CN103880762B (zh) | 2014-04-08 | 2016-03-16 | 河南师范大学 | 一种1,2,3-三氮唑类化合物的制备方法 |
CN103893107B (zh) | 2014-04-10 | 2016-02-24 | 哈尔滨欧替药业有限公司 | 硝酸舍他康唑阴道膨胀栓及其制备方法和检测方法 |
EP3139908A4 (en) * | 2014-05-05 | 2018-05-16 | Repros Therapeutics Inc. | Formulations and methods for vaginal delivery of antiprogestins |
CN103961334A (zh) | 2014-05-22 | 2014-08-06 | 山东津美生物科技有限公司 | 普鲁兰多糖空心硬胶囊及其制备方法 |
CN103961335B (zh) | 2014-05-22 | 2016-01-13 | 山东津美生物科技有限公司 | 普鲁兰多糖软胶囊及其制备方法 |
CN104082851A (zh) | 2014-07-08 | 2014-10-08 | 山东津美生物科技有限公司 | 烟草粘合剂及其制备方法与应用 |
CN104059560A (zh) | 2014-07-08 | 2014-09-24 | 山东津美生物科技有限公司 | 卷烟搭口粘合剂及其制备方法 |
CN104256251B (zh) | 2014-09-04 | 2017-11-28 | 甘肃祁连雪淀粉工贸有限公司 | 含复合添加剂的无明矾薯类淀粉制品及其制备方法 |
CN104222265B (zh) | 2014-09-09 | 2016-08-17 | 曲阜师范大学 | 一种络合物保鲜剂及其在果蔬保鲜中的应用 |
CN104432492A (zh) | 2014-11-03 | 2015-03-25 | 云南中烟工业有限责任公司 | 普鲁兰多糖或其复配物在卷烟中的应用 |
CN104401075A (zh) | 2014-11-24 | 2015-03-11 | 天津市天塑特种母料有限公司 | 一种具有隔氧性改性制剂的bopp复合薄膜的制备方法 |
CN104859237B (zh) | 2014-11-27 | 2017-06-06 | 天津市金盛昱塑料制品有限公司 | 一种具有隔氧性的可降解三层共挤塑料复合薄膜 |
CN104861246B (zh) | 2014-11-27 | 2017-09-12 | 天津市金盛昱塑料制品科技股份有限公司 | 一种具有隔氧性的可降解塑料复合薄膜的制备方法 |
CN104473822A (zh) | 2014-12-02 | 2015-04-01 | 东莞市荷花食品有限公司 | 一种含有植物提取物漱口片及其制作方法 |
CN104403135B (zh) | 2014-12-02 | 2016-08-17 | 天津北洋百川生物技术有限公司 | 一种液体地膜及其制备方法 |
CN104448019B (zh) | 2014-12-05 | 2016-09-28 | 通辽梅花生物科技有限公司 | 高纯普鲁兰多糖提取工艺 |
CN104436204A (zh) | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | 普鲁兰多糖胶囊及其制备工艺 |
CN104479038B (zh) | 2014-12-05 | 2016-09-28 | 通辽梅花生物科技有限公司 | 普鲁兰多糖提纯工艺 |
CN104448403A (zh) | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | 普鲁兰多糖胶及其制造工艺 |
CN104450827A (zh) | 2014-12-16 | 2015-03-25 | 苏州大学 | 提高出芽短梗霉静息细胞生物合成普鲁兰多糖产量的方法 |
CN104711374B (zh) | 2014-12-26 | 2017-08-18 | 天津北洋百川生物技术有限公司 | 一种双段控温并流加吐温60提高普鲁兰多糖产量的方法 |
CN104762753B (zh) | 2014-12-26 | 2017-12-01 | 天津北洋百川生物技术有限公司 | 负载药物的γ‑聚谷氨酸普鲁兰多糖纳米纤维膜的制备方法 |
CN104911231A (zh) | 2014-12-26 | 2015-09-16 | 天津北洋百川生物技术有限公司 | 补料发酵提高普鲁兰多糖产量的方法 |
CN104609992B (zh) | 2014-12-31 | 2017-06-09 | 天津北洋百川生物技术有限公司 | 一种盐碱地专用复合菌肥及其制备方法 |
CN104611783B (zh) | 2015-01-27 | 2016-08-17 | 大连工业大学 | 一种静电纺丝制备纳米纤维的方法及其得到的纳米纤维和纳米纤维的应用 |
CN104651405A (zh) | 2015-02-06 | 2015-05-27 | 大连理工大学 | 一种基于普鲁兰多糖的负载药物和基因的载体、及其制备方法和应用 |
CN104725652B (zh) | 2015-04-02 | 2018-02-16 | 兰州城市学院 | 可降解复合普鲁兰多糖膜的制备方法 |
CN104798975B (zh) | 2015-04-21 | 2017-11-10 | 山东福瑞达生物科技有限公司 | 一种普鲁兰多糖爽口片生产过程粘板的解决方法 |
CN104824508A (zh) | 2015-04-21 | 2015-08-12 | 山东福瑞达生物科技有限公司 | 一种乳酸链球菌素爽口片及其制备方法 |
CN104799145A (zh) | 2015-04-21 | 2015-07-29 | 山东福瑞达生物科技有限公司 | 一种抑制口腔细菌的防龋齿爽口片及其制备方法 |
CN104861214A (zh) | 2015-05-26 | 2015-08-26 | 西北大学 | 普鲁兰多糖可注射水凝胶及其制备方法 |
CN104857560A (zh) | 2015-05-26 | 2015-08-26 | 西北大学 | 羧基化普鲁兰多糖可注射水凝胶及其制备方法 |
CN104861178A (zh) | 2015-05-26 | 2015-08-26 | 西北大学 | 普鲁兰多糖-透明质酸水凝胶及其制备方法 |
CN104844810A (zh) | 2015-05-26 | 2015-08-19 | 西北大学 | 普鲁兰多糖-类人胶原蛋白水凝胶及其制备方法 |
CN104927266A (zh) | 2015-06-02 | 2015-09-23 | 铜陵方正塑业科技有限公司 | 一种保水性佳的全降解塑料薄膜及其制作方法 |
CN104840447A (zh) | 2015-06-15 | 2015-08-19 | 湖北人福药用辅料股份有限公司 | 一种普鲁兰多糖空心胶囊的制备方法 |
CN104906622B (zh) | 2015-06-15 | 2018-05-18 | 山东省药学科学院 | 一种植物基半互穿网络止血敷料及其制备方法 |
CN105039276B (zh) | 2015-06-25 | 2018-03-16 | 杭州师范大学 | 普鲁兰合成酶、编码基因、载体及应用 |
CN105039281A (zh) | 2015-06-25 | 2015-11-11 | 杭州师范大学 | 出芽短梗霉udpg焦磷酸酶、编码基因、载体及应用 |
CN105028864B (zh) | 2015-06-30 | 2018-10-30 | 朱丹 | 一种黑茶提取物口含片及其制备方法 |
CN104911232B (zh) | 2015-07-08 | 2018-02-06 | 西南大学 | 免疫抑制剂雷帕霉素在提高出芽短梗霉普鲁兰多糖产量中的应用及方法 |
CN105055365B (zh) | 2015-07-31 | 2018-01-02 | 刘百平 | 一种普鲁兰多糖空心胶囊的制作工艺 |
CN105106181A (zh) | 2015-09-23 | 2015-12-02 | 成都艾比科生物科技有限公司 | 一种水杨酸普鲁兰多糖涂膜剂及其制备方法 |
CN105267060A (zh) | 2015-11-20 | 2016-01-27 | 扬州中福生物技术有限公司 | 一种银基去屑洗发水及其制备方法 |
JP7222911B2 (ja) | 2017-04-14 | 2023-02-15 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | プルランを作製する方法 |
AU2018251256B2 (en) | 2017-04-14 | 2023-10-05 | Capsugel Belgium Nv | Pullulan capsules |
-
2018
- 2018-04-10 AU AU2018251256A patent/AU2018251256B2/en active Active
- 2018-04-10 BR BR112019021391A patent/BR112019021391A2/pt unknown
- 2018-04-10 CA CA3059527A patent/CA3059527A1/en active Pending
- 2018-04-10 US US16/604,540 patent/US11576870B2/en active Active
- 2018-04-10 CN CN201880025113.3A patent/CN110678170A/zh active Pending
- 2018-04-10 EP EP18724311.8A patent/EP3609476A1/en active Pending
- 2018-04-10 WO PCT/IB2018/000448 patent/WO2018189584A1/en active Application Filing
- 2018-04-10 JP JP2019555931A patent/JP2020516653A/ja active Pending
-
2022
- 2022-12-22 JP JP2022205189A patent/JP2023052025A/ja active Pending
- 2022-12-22 US US18/145,463 patent/US11878079B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000336028A (ja) * | 1999-03-24 | 2000-12-05 | Fuji Capsule Kk | カプセル剤 |
JP2003505565A (ja) * | 1999-07-22 | 2003-02-12 | ワーナー−ランバート・カンパニー | プルラン膜組成物 |
WO2002088246A1 (fr) * | 2001-04-26 | 2002-11-07 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Objet moule ayant une teneur de pullulane elevee, son procede de production et son utilisation |
JP2007536308A (ja) * | 2004-05-04 | 2007-12-13 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 改良されたプルランカプセル |
JP2015518052A (ja) * | 2012-05-31 | 2015-06-25 | レプロス セラピューティクス インコーポレイティド | 抗プロゲスチンの経膣送達用製剤およびその送達方法 |
Non-Patent Citations (2)
Title |
---|
INTERNATIONAL JOURNAL OF RESEARCH IN MARINE SCIENCES, vol. 2, no. 2, JPN6021052280, 2013, pages 39 - 44, ISSN: 0004854002 * |
JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 60, no. 4, JPN6021052281, 1983, pages 862 - 869, ISSN: 0004854001 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
Also Published As
Publication number | Publication date |
---|---|
CA3059527A1 (en) | 2018-10-18 |
BR112019021391A2 (pt) | 2020-05-05 |
US20200289422A1 (en) | 2020-09-17 |
WO2018189584A9 (en) | 2019-01-17 |
JP2023052025A (ja) | 2023-04-11 |
US20230131084A1 (en) | 2023-04-27 |
AU2018251256B2 (en) | 2023-10-05 |
CN110678170A (zh) | 2020-01-10 |
US11576870B2 (en) | 2023-02-14 |
AU2018251256A1 (en) | 2019-11-28 |
US11878079B2 (en) | 2024-01-23 |
EP3609476A1 (en) | 2020-02-19 |
WO2018189584A1 (en) | 2018-10-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11878079B2 (en) | Pullulan capsules | |
DE69918703T2 (de) | Filmbildende zusammensetzungen aus modifizierter stärke | |
JP3822810B2 (ja) | カプセルの密封方法 | |
CN1241991C (zh) | 明胶组合物 | |
US20210220285A1 (en) | Acid resistant capsules | |
JP2006526057A (ja) | 均一で熱可逆性の低粘度ポリマンナンガムフィルム及びそれからつくったソフトカプセル | |
CN106063783B (zh) | 一种黄体酮缓释微囊制剂及其制备方法 | |
WO2006070578A1 (ja) | 硬カプセルのバンドシール | |
JP7263465B2 (ja) | 親水性着色食品濃縮物を含む組成物及び得られるハードカプセル | |
JP2005137935A (ja) | 硬質カプセル及びその製造方法 | |
CA2965425C (en) | Dosage form articles for external mucosal applications | |
JP6267066B2 (ja) | 放出制御型ソフトカプセル剤 | |
WO2023250297A1 (en) | Film forming delayed/enteric formulations for hard shell capsules, films and coatings | |
MXPA02000739A (en) | Pullulan film compositions | |
TW201542246A (zh) | 可食用含植物性組成之素食膠囊配方及其製備方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191018 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210406 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210406 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20211228 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220104 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220331 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20220823 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20221222 |
|
C116 | Written invitation by the chief administrative judge to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C116 Effective date: 20230110 |
|
C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20230110 |