EA201500604A1 - Пленочная лекарственная форма, содержащая свободное основание силденафила, и способ ее получения - Google Patents

Пленочная лекарственная форма, содержащая свободное основание силденафила, и способ ее получения

Info

Publication number
EA201500604A1
EA201500604A1 EA201500604A EA201500604A EA201500604A1 EA 201500604 A1 EA201500604 A1 EA 201500604A1 EA 201500604 A EA201500604 A EA 201500604A EA 201500604 A EA201500604 A EA 201500604A EA 201500604 A1 EA201500604 A1 EA 201500604A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sildenafil
obtaining
form containing
free basis
medical form
Prior art date
Application number
EA201500604A
Other languages
English (en)
Inventor
Хонг-Риеол Дзеонг
Бонг-Санг Ли
Су-Дзун Парк
Бонг-Геун Ча
Дзун-Ки Ким
Original Assignee
СиТиСи БАЙО, ИНК.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by СиТиСи БАЙО, ИНК. filed Critical СиТиСи БАЙО, ИНК.
Publication of EA201500604A1 publication Critical patent/EA201500604A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Moulding By Coating Moulds (AREA)

Abstract

Настоящее изобретение представляет способ приготовления пленки, содержащей большое количество свободного основания силденафила, равномерно в ней диспергированного, и имеющей толщину и размер, так же как и упругость, обеспечивающие хорошую устойчивость и отсутствие склонности к повреждениям. Настоящее изобретение также представляет пленку, содержащую свободное основание силденафила, приготовленную таким способом.
EA201500604A 2011-02-11 2012-02-13 Пленочная лекарственная форма, содержащая свободное основание силденафила, и способ ее получения EA201500604A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20110012516 2011-02-11

Publications (1)

Publication Number Publication Date
EA201500604A1 true EA201500604A1 (ru) 2015-09-30

Family

ID=46639094

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201500604A EA201500604A1 (ru) 2011-02-11 2012-02-13 Пленочная лекарственная форма, содержащая свободное основание силденафила, и способ ее получения
EA201391156A EA027720B1 (ru) 2011-02-11 2012-02-13 Способ получения пленки, содержащей свободное основание силденафила

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201391156A EA027720B1 (ru) 2011-02-11 2012-02-13 Способ получения пленки, содержащей свободное основание силденафила

Country Status (19)

Country Link
US (1) US9907759B2 (ru)
EP (1) EP2674154B1 (ru)
JP (1) JP5973467B2 (ru)
KR (1) KR102010577B1 (ru)
CN (2) CN103402504B (ru)
AU (1) AU2012214939B2 (ru)
BR (1) BR112013020237A2 (ru)
CA (1) CA2827069C (ru)
EA (2) EA201500604A1 (ru)
ES (1) ES2691629T3 (ru)
IL (1) IL227931A (ru)
MA (1) MA34960B1 (ru)
MX (1) MX349803B (ru)
MY (1) MY163288A (ru)
SG (1) SG192284A1 (ru)
TN (1) TN2013000342A1 (ru)
UA (1) UA112540C2 (ru)
WO (1) WO2012108738A2 (ru)
ZA (1) ZA201306650B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2864322C (en) * 2012-02-28 2016-08-09 Seoul Pharma. Co., Ltd. High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient
WO2014137189A1 (ko) * 2013-03-07 2014-09-12 에스케이케미칼주식회사 고함량의 약물을 함유하는 구강 붕해 필름 및 이의 제조방법
CN105209025B (zh) * 2013-04-11 2019-06-18 西梯茜生命工学股份有限公司 包括聚乙二醇类聚合物和/或乙烯基吡咯烷酮类聚合物作为分散稳定剂的含他达拉非游离碱的膜剂形式
US11116769B2 (en) 2013-04-11 2021-09-14 Ctc Bio, Inc. Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer
TWI671085B (zh) * 2013-05-10 2019-09-11 韓商西梯茜生命工學股份有限公司 含有多奈哌齊游離鹽基之膜配方及其之製造方法
CN104352462A (zh) * 2014-10-22 2015-02-18 张艳芬 一种提高昔多芬药物功效的方法
ES2584248B1 (es) * 2015-03-24 2017-04-19 Farmalider, S.A. Composición farmacéutica de citrato de sildenafilo en forma de suspensión para uso oral
CA3059527A1 (en) 2017-04-14 2018-10-18 Capsugel Belgium Nv Pullulan capsules
BR112019021396A2 (pt) 2017-04-14 2020-04-28 Capsugel Belgium Nv processo para fabricação de pululano
CN109010324B (zh) * 2018-08-30 2021-07-02 南京康川济医药科技有限公司 一种西地那非口溶膜剂及其制备方法
US11179331B1 (en) 2020-04-21 2021-11-23 Cure Pharmaceutcai Holding Corp Oral soluble film containing sildenafil citrate

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1239349A (en) * 1983-10-10 1988-07-19 Eberhard F. Gottwald Pharmaceutical composition containing cimetidine
GT199900061A (es) * 1998-05-15 2000-10-14 Pfizer Formulaciones farmaceuticas.
US6552024B1 (en) * 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
JP4173670B2 (ja) * 2002-03-08 2008-10-29 旭化成ファーマ株式会社 口腔内崩壊製剤
JP5148801B2 (ja) 2002-09-09 2013-02-20 エスエス製薬株式会社 催眠用固形製剤
FR2850275B1 (fr) * 2003-01-24 2005-04-08 Scherer Technologies Inc R P Capsules molles a macher contenant une substance active a gout masque
US20050042177A1 (en) 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base
JP4547994B2 (ja) * 2004-06-02 2010-09-22 救急薬品工業株式会社 塊状物質含有積層フィルム状の可食性口腔内投与剤の製造方法および塊状物質含有積層フィルム状の可食性口腔内投与剤
AU2006212021B2 (en) * 2005-02-10 2010-09-30 Orexo Ab Pharmaceutical compositions useful in the transmucosal administration of drugs
EP2037752A2 (en) * 2006-06-16 2009-03-25 Tate & Lyle Ingredients Americas, Inc. Pullulan films and their use in edible packaging
PL2248519T3 (pl) * 2006-10-02 2018-04-30 Apr Applied Pharma Research S.A. Niemukoadhezyjne postaci dawkowania w postaci filmu
US20090047330A1 (en) * 2007-08-17 2009-02-19 Ramesh Bangalore Oral fast dissolving films for erectile dysfunction bioactive agents
KR100920106B1 (ko) * 2007-11-14 2009-10-01 경북대학교 산학협력단 구연산 실데나필을 경피적으로 전달하기 위한 조절 약물전달체 및 이를 포함하는 경피 패치
KR101074271B1 (ko) * 2009-06-25 2011-10-17 (주)차바이오앤디오스텍 불쾌한 맛을 효과적으로 은폐한 경구용 속용 필름
KR20110041412A (ko) * 2009-10-15 2011-04-21 (주)씨엘팜 Ｐｄｅ5 억제제를 함유하는 구강 용해성 필름

Also Published As

Publication number Publication date
CA2827069A1 (en) 2012-08-16
ZA201306650B (en) 2015-06-24
EP2674154A4 (en) 2015-04-01
MX2013009240A (es) 2013-08-29
MY163288A (en) 2017-08-30
EA027720B1 (ru) 2017-08-31
MX349803B (es) 2017-08-14
SG192284A1 (en) 2013-09-30
CN103402504B (zh) 2015-10-14
CN103402504A (zh) 2013-11-20
CN105250242B (zh) 2018-09-21
EP2674154A2 (en) 2013-12-18
EP2674154B1 (en) 2018-08-01
CA2827069C (en) 2021-02-16
CN105250242A (zh) 2016-01-20
US9907759B2 (en) 2018-03-06
WO2012108738A2 (ko) 2012-08-16
JP2014505098A (ja) 2014-02-27
EA201391156A1 (ru) 2014-02-28
KR102010577B1 (ko) 2019-08-13
AU2012214939B2 (en) 2016-11-17
JP5973467B2 (ja) 2016-08-23
US20130323307A1 (en) 2013-12-05
AU2012214939A1 (en) 2013-09-19
IL227931A (en) 2017-03-30
KR20120101301A (ko) 2012-09-13
ES2691629T3 (es) 2018-11-28
BR112013020237A2 (pt) 2021-03-16
IL227931A0 (en) 2013-09-30
MA34960B1 (fr) 2014-03-01
TN2013000342A1 (en) 2015-01-20
WO2012108738A3 (ko) 2012-10-26
UA112540C2 (uk) 2016-09-26

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