HRP20171653T1 - Vezna sredstva koja služe ciljano protiv b7-h1 - Google Patents
Vezna sredstva koja služe ciljano protiv b7-h1 Download PDFInfo
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- HRP20171653T1 HRP20171653T1 HRP20171653TT HRP20171653T HRP20171653T1 HR P20171653 T1 HRP20171653 T1 HR P20171653T1 HR P20171653T T HRP20171653T T HR P20171653TT HR P20171653 T HRP20171653 T HR P20171653T HR P20171653 T1 HRP20171653 T1 HR P20171653T1
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- amino acid
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- 239000011230 binding agent Substances 0.000 title 1
- 239000012634 fragment Substances 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 6
- 101710094000 Programmed cell death 1 ligand 1 Proteins 0.000 claims 6
- 102000048776 human CD274 Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 241000282560 Macaca mulatta Species 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 206010043515 Throat cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010918 connective tissue cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 201000005443 oral cavity cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 229940021747 therapeutic vaccine Drugs 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (24)
1. Izolirano protutijelo ili njegov vezni fragment, koje/koji se specifično veže na ljudski
B7-H1, naznačen/o time, da to protutijelo ili njegov vezni fragment obuhvaća sljedeće:
VH-CDR1 koje ima aminokiselinsku sekvencu GFTFSRYWMS; i
VH-CDR2 koje ima aminokiselinsku sekvencu NIKQDGSEKYYVDSVKG; i
VH-CDR3 koje ima aminokiselinsku sekvencu EGGWFGELAFDY; i
VL-CDR1 koje ima aminokiselinsku sekvencu RASQRVSSSYLA; i
VL-CDR2 koje ima aminokiselinsku sekvencu DASSRAT; i
VL CDR3 koje ima aminokiselinsku sekvencu QQYGSLPWT;
te pritom to protutijelo ili njegov vezni fragment inhibira proliferaciju tumora induciranog putem B7-H1.
2. Izolirano protutijelo ili njegov vezni fragment prema zahtjevu 1, naznačen/o time, da to protutijelo ili njegov vezni fragment veže ljudski B7-H1 s jednim KD koji je manji od 2 nM, kao što je određeno pomoću BIAcore na 25°C u HBS-EP-puferu.
3. Izolirano protutijelo ili njegov vezni fragment prema zahtjevu 1 ili 2, naznačen/o time, da to protutijelo ili njegov vezni fragment unakrsno reagira s rezus-majmunskim B7-H1.
4. Izolirano protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 3, naznačen/o time, da to protutijelo ili njegov fragment veže rezus-majmunski B7-H1 s jednim KD koji je manji od 2 nM, kao što je određeno pomoću BIAcore na 25°C u HBS-EP-puferu.
5. Izolirano protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 4, naznačen/o time, da to protutijelo ili njegov fragment pokazuje aktivaciju T-stanica CD4+ u miješanoj limfocitnoj analizi s dendritičkim stanicama i T-stanicama.
6. Izolirano protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 5, naznačen/o time, da to protutijelo ili njegov fragment inhibira vezanje ljudskog B7-H1 na PD-1 koji je izražen na ES-2-stanicama, s jednim IC50 koji je manji od 0,2 nM.
7. Izolirano protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 6, naznačen/o time, da to protutijelo ili njegov fragment inhibira vezanje ljudskog B7-H1 na B7-1 posredstvom homogene TR-FRET-analize s jednim IC50 koji je manji od 0,1 nM.
8. Izolirano protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 7, koje/koji se specično veže na B7-H1, naznačen/o time, da to protutijelo veže ljudski
B7-H1 s jednim KD koji je manji od 1,0 nM, kao što je određeno pomoću BIAcore na 25°C u HBS-EP-puferu; ili
pri čemu spomenuto protutijelo veže ljudski B7-H1 s jednim KD koji je manji od 200 pM, kao što je određeno pomoću BIAcore na 25°C u HBS-EP-puferu.
9. Protutijelo prema bilo kojem od prethodnih zahtjeva, naznačeno time, da se kod navedenog protutijela radi o cjelovitom ljudskom monoklonskom protutijelu.
10. Vezni fragment prema bilo kojem od prethodnih zahtjeva, naznačen time, da je navedeni vezni fragment odabran iz skupine koju čine sljedeći fragmenti: Fab, Fab', F(ab')2, Fv i dAb.
11. Protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 7, naznačen/o time, da ima aminokiselinsku sekvencu koja obuhvaća sljedeće:
jednu aminokiselinsku sekvencu varijabilne domene jakog lanca, koja se kodira putem polinukleotida u plazmidu označenom kao 2.14H9_G koji je deponiran u NCIMB pod depozitnim brojem 41597, i jednu aminokiselinsku sekvencu varijabilne domene slabog lanca, koja se kodira putem polinukleotida u plazmidu označenom kao 2.14H9_G koji je deponiran u NCIMB pod depozitnim brojem 41597.
12. Izolirano protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 7, naznačen/o time, da to protutijelo ili njegov vezni fragment imunospecifično veže
B7-H1, te time, da obuhvaća sljedeće:
jednu varijabilnu domenu jakog lanca koja ima najmanje 90% identiteta sekvence aminokiseline od SEQ ID NO:72; i
jednu varijabilnu domenu slabog lanca koja ima najmanje 90% identiteta sekvence aminokiseline od SEQ ID NO:77;
pri čemu navedeno protutijelo ima aktivitet za vezanje na B7-H1.
13. Protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 7, 11 ili 12, naznačen/o time, da navedeno protutijelo nadalje obuhvaća Fc-varijantu, pri čemu
Fc-područje obuhvaća najmanje jednu aminokiselinu koja se ne pojavljuje prirodno, i koja je odabrana iz skupine koju čine 234F, 235F i 331S, kao što je numerirano pomoću EU-indeksa predstavljenog u Kabat-u.
14. Molekula nukleinske kiseline, naznačena time, da ona kodira protutijelo ili njegov vezni fragment prema bilo kojem od prethodnih zahtjeva.
15. Stanica domaćina, naznačena time, da je transficirana s vektorom koji obuhvaća molekulu nukleinske kiseline prema zahtjevu 14.
16. Protutijelo, naznačeno time, da se proizvodi putem postupka koji uključuje kultiviranje stanice domaćina prema zahtjevu 15, koje vrši ekspresiju protutijela kodiranog putem navedene molekule nukleinske kiseline prema zahtjevu 14, te izoliranje navedenog protutijela iz spomenute kulture.
17. Sastav, naznačen time, da obuhvaća protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 12.
18. Farmaceutski sastav, naznačen time, da obuhvaća protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 12, te farmaceutski prikladan nosač.
19. Farmaceutski sastav prema zahtjevu 18, naznačen time, da se upotrebljava u liječenju.
20. Farmaceutski sastav prema zahtjevu 18, naznačen time, da se upotrebljava u liječenju malignih tumora kod životinje; i prema potrebi kada je navedena životinja ljudsko biće.
21. Farmaceutski sastav za uporabu prema zahtjevu 20, naznačen time, da je spomenuti maligni tumor odabran iz skupine koju čine: melanom, rak ne-malih stanica pluća, hepatostanični karcinom, rak želudca, rak mjehura, rak pluća, karcinom renalnih stanica, rak grlića maternice, rak debelog crijeva, kolorektalni rak, rak glave i vrata, rak dojke, rak jednjaka, rak kosti, rak prostate, karcinom bazalnih stanica, rak žučnih vodova, rak mozga i CNS-rak, horionkarcinom, rak veznog tkiva, rak probavnog sustava, endometrijski rak, rak oka, intra-epitelni rak, rak bubrega, rak grla, leukemija, rak jetre, rak pluća, limfom, mijelom, neuroblastom, rak usne šupljine, rak jajnika, rabdomiosarkom, sarkom, rak kože, rak testisa, rak štitnjače, rak maternice, rak mokraćnih vodova i rak gušterače.
22. Farmaceutski sastav prema zahtjevu 18, naznačen time, da se upotrebljava u liječenju kronične virusne infekcije kod životinje; i prema potrebi kada je navedena životinja ljudsko biće.
23. Farmaceutski sastav za uporabu prema zahtjevu 22, naznačen time, da je spomenuta kronična virusna infekcija odabrana iz skupine koju čine: HIV, HBV i HCV.
24. Protutijelo ili njegov vezni fragment prema bilo kojem od zahtjeva 1 do 12, ili 16, naznačen/o time, da je namijenjen/o za primjenu samostalno ili u kombinaciji s dodatnim protutijelima, kemoterapeutskim lijekovima, radijacijskom terapijom ili terapeutskim cjepivima.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26406109P | 2009-11-24 | 2009-11-24 | |
EP10833923.5A EP2504364B1 (en) | 2009-11-24 | 2010-11-24 | Targeted binding agents against b7-h1 |
PCT/US2010/058007 WO2011066389A1 (en) | 2009-11-24 | 2010-11-24 | Targeted binding agents against b7-h1 |
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HRP20171653T1 true HRP20171653T1 (hr) | 2017-12-15 |
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HRP20171653TT HRP20171653T1 (hr) | 2009-11-24 | 2017-10-30 | Vezna sredstva koja služe ciljano protiv b7-h1 |
HRP20200383TT HRP20200383T1 (hr) | 2009-11-24 | 2020-03-09 | Ciljana vezna sredstva protiv b7-h1 |
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