DK3221355T3 - Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister - Google Patents

Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister Download PDF

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Publication number
DK3221355T3
DK3221355T3 DK15797954.3T DK15797954T DK3221355T3 DK 3221355 T3 DK3221355 T3 DK 3221355T3 DK 15797954 T DK15797954 T DK 15797954T DK 3221355 T3 DK3221355 T3 DK 3221355T3
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folr1
well
combination therapy
bispecific antigen
folate receptor
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DK15797954.3T
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Christian Klein
Vaios Karanikas
Pablo Umana
Alfred Zippelius
Daniela Thommen
Jens Schreiner
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Hoffmann La Roche
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817Toxins
    • A61K47/6829Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
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    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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DK15797954.3T 2014-11-20 2015-11-16 Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister DK3221355T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14194136 2014-11-20
EP15152141 2015-01-22
EP15167173 2015-05-11
PCT/EP2015/076682 WO2016079050A1 (en) 2014-11-20 2015-11-16 Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists

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Publication Number Publication Date
DK3221355T3 true DK3221355T3 (da) 2020-12-07

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DK20181448.0T DK3789402T3 (da) 2014-11-20 2015-11-16 Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler og PD-1-aksebindende antagonister
DK15797954.3T DK3221355T3 (da) 2014-11-20 2015-11-16 Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister

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DK20181448.0T DK3789402T3 (da) 2014-11-20 2015-11-16 Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler og PD-1-aksebindende antagonister

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US (2) US10781262B2 (da)
EP (3) EP3789402B1 (da)
JP (2) JP6944369B2 (da)
KR (2) KR20240024318A (da)
CN (1) CN107206072B (da)
AU (1) AU2015348657B2 (da)
BR (1) BR112017010324A2 (da)
CA (1) CA2966566C (da)
DK (2) DK3789402T3 (da)
ES (2) ES2835823T3 (da)
HR (2) HRP20221083T1 (da)
HU (2) HUE052831T2 (da)
IL (1) IL251961B (da)
LT (2) LT3221355T (da)
MX (1) MX2017006610A (da)
MY (1) MY192999A (da)
PL (2) PL3221355T3 (da)
RS (2) RS63564B1 (da)
RU (1) RU2753902C2 (da)
SG (1) SG11201704056XA (da)
SI (2) SI3789402T1 (da)
WO (1) WO2016079050A1 (da)
ZA (1) ZA201703121B (da)

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