BR122020013239B1 - Anticorpo anti-cd20 humano tipo ii humanizado, seus usos, bem como composição farmacêutica - Google Patents
Anticorpo anti-cd20 humano tipo ii humanizado, seus usos, bem como composição farmacêutica Download PDFInfo
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51709603P | 2003-11-05 | 2003-11-05 | |
| US60/517,096 | 2003-11-05 | ||
| PCT/IB2004/003896 WO2005044859A2 (en) | 2003-11-05 | 2004-11-05 | Cd20 antibodies with increased fc receptor binding affinity and effector function |
| BRPI0416262-5A BRPI0416262B1 (pt) | 2003-11-05 | 2004-11-05 | Anticorpo anti-cd20 humano tipo ii humanizado, seu método de produção, seus usos, bem como polinucleotídeo isolado, vetor de expressão e composição farmacêutica |
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| Publication Number | Publication Date |
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| BR122020013239B1 true BR122020013239B1 (pt) | 2022-05-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| BRPI0416262-5A BRPI0416262B1 (pt) | 2003-11-05 | 2004-11-05 | Anticorpo anti-cd20 humano tipo ii humanizado, seu método de produção, seus usos, bem como polinucleotídeo isolado, vetor de expressão e composição farmacêutica |
| BR122020013239-6A BR122020013239B1 (pt) | 2003-11-05 | 2004-11-05 | Anticorpo anti-cd20 humano tipo ii humanizado, seus usos, bem como composição farmacêutica |
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| BRPI0416262-5A BRPI0416262B1 (pt) | 2003-11-05 | 2004-11-05 | Anticorpo anti-cd20 humano tipo ii humanizado, seu método de produção, seus usos, bem como polinucleotídeo isolado, vetor de expressão e composição farmacêutica |
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Families Citing this family (885)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| CA2838062C (en) | 2001-08-03 | 2015-12-22 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| KR101412271B1 (ko) | 2003-05-09 | 2014-06-25 | 듀크 유니버시티 | Cd20-특이적 항체 및 이를 이용한 방법 |
| TR201809892T4 (tr) | 2003-11-05 | 2018-07-23 | Roche Glycart Ag | Fc reseptörüne bağlanma afinitesi ve artırılmış efektör fonksiyonu bulunan antijen bağlayan moleküller. |
| EP1781378A2 (en) * | 2004-07-22 | 2007-05-09 | Genentech, Inc. | Method of treating sjögren's syndrome |
| DK2213683T3 (da) | 2004-08-04 | 2013-09-02 | Mentrik Biotech Llc | VARIANT-Fc-REGIONER |
| ZA200702335B (en) * | 2004-10-05 | 2009-05-27 | Genentech Inc | Method for treating vasculitis |
| WO2006082515A2 (en) | 2005-02-07 | 2006-08-10 | Glycart Biotechnology Ag | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
| CA2605781A1 (en) * | 2005-05-09 | 2007-04-12 | Glycart Biotechnology Ag | Antigen binding molecules having modified fc regions and altered binding to fc receptors |
| CN101223448B (zh) * | 2005-05-20 | 2012-01-18 | 健泰科生物技术公司 | 来自自身免疫病受试者的生物学样品的预处理 |
| AU2006255085A1 (en) * | 2005-06-03 | 2006-12-14 | Genentech, Inc. | Method of producing antibodies with modified fucosylation level |
| JP2009501913A (ja) | 2005-07-21 | 2009-01-22 | ゲンマブ エー/エス | Fc受容体と結合する抗体原薬に関する効力アッセイ |
| NO345919B1 (no) * | 2005-08-26 | 2021-10-18 | Roche Glycart Ag | Modifiserte antigen-bindende molekyler med endret celle-signaliseringsaktivitet |
| AU2012216702B2 (en) * | 2005-08-26 | 2014-12-04 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
| EP2455100A3 (en) * | 2005-11-07 | 2012-11-07 | The Rockefeller University | Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof |
| US8470318B2 (en) * | 2005-11-07 | 2013-06-25 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| US20080206246A1 (en) * | 2006-04-05 | 2008-08-28 | Ravetch Jeffrey V | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| EP1954719A2 (en) | 2005-12-02 | 2008-08-13 | Genentech Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r |
| JP5164856B2 (ja) | 2006-01-05 | 2013-03-21 | ジェネンテック, インコーポレイテッド | 抗ephb4抗体およびその使用方法 |
| EP2623610B1 (en) * | 2006-02-10 | 2015-04-29 | Life Technologies Corporation | Labeling and detection of post translationally modified proteins |
| AR059851A1 (es) | 2006-03-16 | 2008-04-30 | Genentech Inc | Anticuerpos de la egfl7 y metodos de uso |
| CN101432301B (zh) * | 2006-04-05 | 2014-01-08 | 洛克菲勒大学 | 具有增强的抗炎性和降低的细胞毒性特性的多肽以及相关方法 |
| US8524865B2 (en) | 2006-05-30 | 2013-09-03 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| CA2654304A1 (en) * | 2006-06-06 | 2007-12-13 | Genentech, Inc. | Compositions and methods for modulating vascular development |
| AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| UA94484C2 (uk) | 2006-10-12 | 2011-05-10 | Дженентек, Інк. | Антитіла до лімфотоксину-альфа |
| MX2009003938A (es) | 2006-10-27 | 2009-04-24 | Genentech Inc | Anticuerpos e inmunoconjugados y sus usos. |
| AU2013202392B2 (en) * | 2006-12-20 | 2016-02-25 | Mmrglobal, Inc. | Antibodies and methods for making and using them |
| KR101378302B1 (ko) | 2006-12-20 | 2014-03-28 | 엠엠알글로벌, 인코포레이티드 | 항체 및 이들의 제조 및 사용 방법 |
| BRPI0806367A2 (pt) | 2007-01-22 | 2011-09-06 | Genentech Inc | métodos de purificação de anticorpos |
| JP2010517944A (ja) * | 2007-01-26 | 2010-05-27 | バイオインヴェント インターナショナル アーベー | Dll4シグナリング阻害薬およびその使用 |
| MX2009008430A (es) | 2007-02-09 | 2009-10-28 | Genentech Inc | Anticuerpos anti-robo4 y sus usos. |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| FR2915398B1 (fr) * | 2007-04-25 | 2012-12-28 | Lab Francais Du Fractionnement | "ensemble de moyens pour le traitement d'une pathologie maligne, d'une maladie auto-immune ou d'une maladie infectieuse" |
| WO2008143878A1 (en) | 2007-05-14 | 2008-11-27 | Medimmune, Llc | Methods of reducing eosinophil levels |
| WO2009000099A2 (en) | 2007-06-25 | 2008-12-31 | Esbatech Ag | Methods of modifying antibodies, and modified antibodies with improved functional properties |
| ES2528922T3 (es) | 2007-07-16 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso |
| RS53595B1 (sr) | 2007-07-16 | 2015-02-27 | Genentech, Inc. | Anti-cd79b antitela i imunokonjugati i metode upotrebe |
| US20110243931A1 (en) * | 2007-09-02 | 2011-10-06 | Thomas Friess | Combination therapy with type i and type ii anti-cd20 antibodies |
| RU2526512C2 (ru) | 2007-09-26 | 2014-08-20 | Чугаи Сейяку Кабусики Кайся | Модифицированная константная область антитела |
| US20090098118A1 (en) * | 2007-10-15 | 2009-04-16 | Thomas Friess | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
| US20090110688A1 (en) * | 2007-10-24 | 2009-04-30 | Georg Fertig | Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor |
| WO2009062102A2 (en) | 2007-11-07 | 2009-05-14 | Genentech, Inc. | Compositions and methods for treatment of microbial disorders |
| TWI580694B (zh) | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-vegf抗體 |
| AU2008340429C1 (en) * | 2007-12-21 | 2016-09-08 | F. Hoffmann-La Roche Ag | Antibody formulation |
| AU2008342956A1 (en) * | 2007-12-21 | 2009-07-09 | Genentech, Inc. | Therapy of rituximab-refractory rheumatoid arthritis patients |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| IL287292B (en) | 2008-01-31 | 2022-09-01 | Genentech Inc | Cycteine engineering anti-cd79b antibodies and antibody-drug conjugates |
| HUE028828T2 (en) * | 2008-03-25 | 2017-01-30 | Roche Glycart Ag | Use of type II anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity (ADDC) in combination with cyclophosphamide, vincristine, and doxorubicin for the treatment of non-hodgkin's lymphomas |
| CN102232113A (zh) * | 2008-03-31 | 2011-11-02 | 健泰科生物技术公司 | 用于治疗和诊断哮喘的组合物和方法 |
| EP2279410B1 (en) * | 2008-04-22 | 2015-11-11 | The Rockefeller University | Methods of identifying anti-inflammatory compounds |
| WO2009134738A1 (en) * | 2008-04-29 | 2009-11-05 | Genentech, Inc. | Responses to immunizations in rheumatoid arthritis patients treated with a cd20 antibody |
| KR101054362B1 (ko) * | 2008-07-03 | 2011-08-05 | 재단법인 목암생명공학연구소 | 재조합 단백질의 푸코스 함량을 감소시키는 방법 |
| EP2318832B1 (en) | 2008-07-15 | 2013-10-09 | Academia Sinica | Glycan arrays on ptfe-like aluminum coated glass slides and related methods |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | Genentech Inc | 治療進展型多發性硬化症之方法 |
| EP3524620A1 (en) | 2008-10-14 | 2019-08-14 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| KR20170143025A (ko) | 2008-12-23 | 2017-12-28 | 제넨테크, 인크. | 단백질 a에 대해 변경된 결합을 갖는 이뮤노글로불린 변이체 |
| AR075896A1 (es) | 2009-03-20 | 2011-05-04 | Genentech Inc | Anticuerpos anti-her (factor de crecimiento epidermico) |
| SG174904A1 (en) * | 2009-03-25 | 2011-11-28 | Genentech Inc | Anti-fgfr3 antibodies and methods using same |
| NZ594343A (en) | 2009-03-25 | 2013-10-25 | Genentech Inc | Novel anti-alpha5beta1 antibodies and uses thereof |
| US20100247484A1 (en) | 2009-03-31 | 2010-09-30 | Heinrich Barchet | Combination therapy of an afucosylated antibody and one or more of the cytokines gm csf, m csf and/or il3 |
| CN102369215B (zh) | 2009-04-02 | 2015-01-21 | 罗切格利卡特公司 | 包含全长抗体和单链Fab片段的多特异性抗体 |
| CA2757531A1 (en) | 2009-04-07 | 2010-10-14 | Roche Glycart Ag | Bispecific anti-erbb-3/anti-c-met antibodies |
| SI2417156T1 (sl) | 2009-04-07 | 2015-06-30 | Roche Glycart Ag | Trivalentna, bispecifiäśna protitelesa |
| SG175078A1 (en) | 2009-04-07 | 2011-11-28 | Roche Glycart Ag | Bispecific anti-erbb-1/anti-c-met antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
| JP5921433B2 (ja) | 2009-07-24 | 2016-05-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 攪拌システム |
| AR077595A1 (es) | 2009-07-27 | 2011-09-07 | Genentech Inc | Tratamientos de combinacion |
| SG178177A1 (en) | 2009-07-31 | 2012-03-29 | Genentech Inc | Inhibition of tumor metastasis using bv8- or g-csf-antagonists |
| WO2011018225A1 (en) | 2009-08-14 | 2011-02-17 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with fludarabine and/or mitoxantrone |
| TWI409079B (zh) | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法 |
| GB0914691D0 (en) | 2009-08-21 | 2009-09-30 | Lonza Biologics Plc | Immunoglobulin variants |
| TWI412375B (zh) | 2009-08-28 | 2013-10-21 | Roche Glycart Ag | 人類化抗cdcp1抗體 |
| TW201113037A (en) | 2009-08-28 | 2011-04-16 | Hoffmann La Roche | Antibodies against CDCP1 for the treatment of cancer |
| US9321823B2 (en) | 2009-09-02 | 2016-04-26 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| MX2012003396A (es) | 2009-09-16 | 2012-04-10 | Genentech Inc | Complejos de proteina conteniendo helice super-enrollada y/o enlazador tether y usos de los mismos. |
| TR201804897T4 (tr) | 2009-10-07 | 2018-06-21 | Macrogenics Inc | Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler |
| AU2010310585A1 (en) | 2009-10-22 | 2012-05-03 | Genentech, Inc. | Anti-hepsin antibodies and methods using same |
| WO2011056502A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Bone morphogenetic protein receptor type ii compositions and methods of use |
| WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
| WO2011056497A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use |
| LT2496691T (lt) | 2009-11-02 | 2017-06-12 | University Of Washington | Terapinės nukleazės kompozicijos ir būdai |
| WO2011056997A1 (en) | 2009-11-04 | 2011-05-12 | Fabrus Llc | Methods for affinity maturation-based antibody optimization |
| CA2780143A1 (en) | 2009-11-05 | 2011-05-12 | Genentech, Inc. | Methods and composition for secretion of heterologous polypeptides |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011071577A1 (en) | 2009-12-11 | 2011-06-16 | Genentech, Inc. | Anti-vegf-c antibodies and methods using same |
| SI2516469T1 (sl) | 2009-12-22 | 2016-05-31 | Roche Glycart Ag | Protitelesa proti her3 in uporabe le-teh |
| RU2559542C2 (ru) | 2009-12-23 | 2015-08-10 | Дженентек, Инк. | Антитела против bv8 и их применение |
| EP2533810B1 (en) * | 2010-02-10 | 2016-10-12 | ImmunoGen, Inc. | Cd20 antibodies and uses thereof |
| EP2534480B1 (en) | 2010-02-11 | 2014-03-19 | F.Hoffmann-La Roche Ag | 3d adcc nk facs assay |
| SG183333A1 (en) | 2010-02-18 | 2012-09-27 | Genentech Inc | Neuregulin antagonists and use thereof in treating cancer |
| JP6093692B2 (ja) | 2010-03-24 | 2017-03-08 | ジェネンテック, インコーポレイテッド | 抗lrp6抗体 |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| EP2374816B1 (en) | 2010-04-07 | 2016-09-28 | Agency For Science, Technology And Research | Binding molecules against Chikungunya virus and uses thereof |
| WO2011124635A1 (en) | 2010-04-07 | 2011-10-13 | Humalys | Binding molecules against chikungunya virus and uses thereof |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| CN102844049B (zh) | 2010-04-27 | 2016-06-01 | 罗切格利卡特公司 | 无岩藻糖基化CD20抗体与mTOR抑制剂的联合疗法 |
| DK2568976T3 (en) | 2010-05-10 | 2016-01-11 | Academia Sinica | Zanamivir-phosphonate congener with the anti-influenza activity, and determining the sensitivity oseltamivir in influenza viruses |
| WO2011147834A1 (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof |
| AU2011261362B2 (en) | 2010-06-03 | 2016-06-09 | Genentech, Inc. | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
| JP5940061B2 (ja) | 2010-06-18 | 2016-06-29 | ジェネンテック, インコーポレイテッド | 抗axl抗体及び使用方法 |
| WO2011161119A1 (en) | 2010-06-22 | 2011-12-29 | F. Hoffmann-La Roche Ag | Antibodies against insulin-like growth factor i receptor and uses thereof |
| WO2011161189A1 (en) | 2010-06-24 | 2011-12-29 | F. Hoffmann-La Roche Ag | Anti-hepsin antibodies and methods of use |
| DK2591006T3 (da) | 2010-07-09 | 2019-07-29 | Bioverativ Therapeutics Inc | Processerbare enkeltkædede molekyler og polypeptider fremstillet ved anvendelse deraf |
| RU2571226C2 (ru) | 2010-07-09 | 2015-12-20 | Дженентек, Инк. | Антитела против нейропилина и способы их применения |
| EP2409989A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Method to improve glycosylation profile for antibody |
| EP2409712A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| FR2962908A1 (fr) | 2010-07-20 | 2012-01-27 | Lfb Biotechnologies | Formulation d'anticorps anti-cd20 |
| WO2012010582A1 (en) | 2010-07-21 | 2012-01-26 | Roche Glycart Ag | Anti-cxcr5 antibodies and methods of use |
| RU2013106216A (ru) | 2010-08-03 | 2014-09-10 | Ф. Хоффманн-Ля Рош Аг | Биомаркеры хронической лимфоцитарной лейкемии |
| WO2012017003A1 (en) | 2010-08-05 | 2012-02-09 | F. Hoffmann-La Roche Ag | Anti-mhc antibody anti-viral cytokine fusion protein |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2806640A1 (en) | 2010-08-13 | 2012-02-16 | Roche Glycart Ag | Anti-tenascin-c a2 antibodies and methods of use |
| HUE036077T2 (hu) | 2010-08-13 | 2018-06-28 | Roche Glycart Ag | Anti-FAP ellenanyagok és alkalmazásukra szolgáló eljárások |
| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| NZ604510A (en) | 2010-08-17 | 2013-10-25 | Csl Ltd | Dilutable biocidal compositions and methods of use |
| AR082693A1 (es) | 2010-08-17 | 2012-12-26 | Roche Glycart Ag | Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf |
| CN103068846B9 (zh) | 2010-08-24 | 2016-09-28 | 弗·哈夫曼-拉罗切有限公司 | 包含二硫键稳定性Fv片段的双特异性抗体 |
| RU2013110874A (ru) | 2010-08-25 | 2014-09-27 | Ф.Хоффманн-Ля Рош Аг | Антитела против il-18r1 и их применения |
| JP2013537966A (ja) | 2010-08-31 | 2013-10-07 | ジェネンテック, インコーポレイテッド | バイオマーカー及び治療の方法 |
| RS63430B1 (sr) | 2010-10-01 | 2022-08-31 | Modernatx Inc | Ribonukleinske kiseline koje sadrže n1-metil-pseudouracile i njihove primene |
| US8481680B2 (en) | 2010-10-05 | 2013-07-09 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| RU2013126477A (ru) | 2010-11-08 | 2014-12-20 | Дженентек, Инк. | Вводимые подкожно антитела против рецептора il-6 |
| WO2012064836A1 (en) | 2010-11-10 | 2012-05-18 | Genentech, Inc. | Methods and compositions for neural disease immunotherapy |
| BR112013013083A2 (pt) | 2010-11-30 | 2016-12-13 | Genentech Inc | métodos para transportar um composto, para aumentar exposição do cns a um composto, para diminuir a depuração de um composto, para aumentar a retenção no cns de um composto, para otimizar a farmacocinética, para tratar um distúrbio neurológico em um mamífero, para desenvolver um anticorpo, anticorpo, fragmento de anticorpo, anticorpo multiespecífico e uso de um anticorpo |
| EP4279513A3 (en) | 2010-11-30 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| EP3447491A3 (en) | 2010-12-16 | 2019-06-05 | F. Hoffmann-La Roche AG | Diagnosis and treatments relating to th2 inhibition |
| CA2819436A1 (en) | 2010-12-16 | 2012-06-21 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with a mdm2 inhibitor |
| TWI477513B (zh) | 2010-12-20 | 2015-03-21 | 建南德克公司 | 抗間皮素(mesothelin)抗體及免疫接合物 |
| CA2820953A1 (en) | 2010-12-22 | 2012-06-28 | Genentech, Inc. | Anti-pcsk9 antibodies and methods of use |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| JP2014511147A (ja) * | 2011-02-10 | 2014-05-12 | ロシュ グリクアート アーゲー | 改善された免疫療法 |
| WO2012116926A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Antigen binding proteins |
| BR112013020338A2 (pt) | 2011-02-28 | 2016-10-18 | Hoffmann La Roche | proteína de ligação de antígeno monovalente, composição farmacêutica, uso da proteína de ligação de antígeno monovalente, método para o tratamento de um paciente com necessidade de terapia, método para a preparação de uma proteína de ligação de antígeno monovalente, ácido nucleico, vetor e célula hospedeira |
| SI2691417T2 (sl) | 2011-03-29 | 2025-05-30 | Roche Glycart Ag | FC variante protitelesa |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| CN103596983B (zh) | 2011-04-07 | 2016-10-26 | 霍夫曼-拉罗奇有限公司 | 抗fgfr4抗体及使用方法 |
| HRP20180564T1 (hr) | 2011-04-29 | 2018-06-01 | University of Washington, UW Center for Commercialization | Terapijski pripravci nukleaze i postupci |
| WO2012146630A1 (en) | 2011-04-29 | 2012-11-01 | F. Hoffmann-La Roche Ag | N-terminal acylated polypeptides, methods for their production and uses thereof |
| MX2013013054A (es) | 2011-05-12 | 2014-02-20 | Genentech Inc | Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura. |
| ES2628385T3 (es) | 2011-05-16 | 2017-08-02 | F. Hoffmann-La Roche Ag | Agonistas de FGFR1 y procedimientos de uso |
| RU2013158627A (ru) | 2011-06-15 | 2015-07-20 | Ф. Хоффманн-Ля Рош Аг | Антитела к рецептору человеческого эритропоэтина и способы их применения |
| FR2976811A1 (fr) | 2011-06-22 | 2012-12-28 | Lfb Biotechnologies | Utilisation d'un anticorps anti-cd20 a haute adcc pour le traitement de la maladie de waldenstrom |
| AU2012274127B2 (en) | 2011-06-22 | 2017-06-22 | F. Hoffmann-La Roche Ag | Removal of target cells by circulating virus-specific cytotoxic T-cells using MHC class I comprising complexes |
| AR086823A1 (es) | 2011-06-30 | 2014-01-22 | Genentech Inc | Formulaciones de anticuerpo anti-c-met, metodos |
| CA2842375A1 (en) | 2011-08-17 | 2013-02-21 | Erica Jackson | Neuregulin antibodies and uses thereof |
| CN103890008A (zh) | 2011-08-17 | 2014-06-25 | 霍夫曼-拉罗奇有限公司 | 在顽固性肿瘤中抑制血管发生 |
| KR101681818B1 (ko) | 2011-08-23 | 2016-12-01 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| KR20140048292A (ko) | 2011-08-23 | 2014-04-23 | 로슈 글리카트 아게 | 항-mcsp 항체 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CN103930781A (zh) | 2011-09-15 | 2014-07-16 | 霍夫曼-拉罗奇有限公司 | 促进分化的方法 |
| KR20140064971A (ko) | 2011-09-19 | 2014-05-28 | 제넨테크, 인크. | c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료 |
| CA2845147A1 (en) | 2011-09-23 | 2013-03-28 | Roche Glycart Ag | Bispecific anti-egfr/anti igf-1r antibodies |
| MX366269B (es) | 2011-09-30 | 2019-07-04 | Chugai Pharmaceutical Co Ltd | Biblioteca de moleculas de union dependientes de la concentracion ionica. |
| MX2014003689A (es) | 2011-09-30 | 2014-12-05 | Teva Pharmaceuticals Australia Pty Ltd | Anticuerpos contra tl1a y sus usos. |
| DK3682905T3 (da) | 2011-10-03 | 2022-02-28 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer og anvendelser deraf |
| US20130089562A1 (en) | 2011-10-05 | 2013-04-11 | Genenthech, Inc. | Methods of treating liver conditions using notch2 antagonists |
| CA2850032C (en) | 2011-10-14 | 2022-06-07 | Genentech, Inc. | Anti-htra1 antibodies and methods of use |
| BR112014008590A2 (pt) | 2011-10-15 | 2017-10-24 | Genentech Inc | métodos de uso de antagonistas de scd1 |
| WO2013059531A1 (en) | 2011-10-20 | 2013-04-25 | Genentech, Inc. | Anti-gcgr antibodies and uses thereof |
| JP6251682B2 (ja) | 2011-10-28 | 2017-12-20 | ジェネンテック, インコーポレイテッド | メラノーマ治療の治療の組み合わせ及び方法 |
| JP2015504413A (ja) | 2011-10-28 | 2015-02-12 | パトリス リミテッド | Pat−lm1エピトープおよびそれを使用するための方法 |
| EP2776061B1 (en) | 2011-11-07 | 2019-08-14 | MedImmune, LLC | Multispecific and multivalent binding proteins and uses thereof |
| CN104066748A (zh) | 2011-11-21 | 2014-09-24 | 霍夫曼-拉罗奇有限公司 | 抗c-met抗体的纯化 |
| US20130302274A1 (en) * | 2011-11-25 | 2013-11-14 | Roche Glycart Ag | Combination therapy |
| WO2013083497A1 (en) | 2011-12-06 | 2013-06-13 | F. Hoffmann-La Roche Ag | Antibody formulation |
| DE12858350T1 (de) | 2011-12-16 | 2021-10-07 | Modernatx, Inc. | Modifizierte mrna zusammensetzungen |
| PT2794905T (pt) | 2011-12-20 | 2020-06-30 | Medimmune Llc | Polipéptidos modificados para estrutura de anticorpos bispecíficos |
| US20160208284A1 (en) | 2011-12-22 | 2016-07-21 | Hoffmann-La Roche Inc. | Expression vector element combinations, novel production cell generation methods and their use for the recombinant production of polypeptides |
| RU2756106C2 (ru) | 2011-12-22 | 2021-09-28 | Ф. Хоффманн-Ля Рош Аг | Строение экспрессионного вектора, новые способы получения клеток-продуцентов и их применение для рекомбинантного получения полипептидов |
| BR112014013035A2 (pt) | 2011-12-22 | 2018-10-09 | Hoffmann La Roche | métodos de seleção de células, conjuntos de expressão bicistrônica, células eucarióticas, vetores lentivirais, uso de vetor lentiviral, bibliotecas de ventores lentivirais e de células eucarióticas, métodos de seleção de células, fluxos de trabalho e uso de célula |
| WO2013096791A1 (en) | 2011-12-23 | 2013-06-27 | Genentech, Inc. | Process for making high concentration protein formulations |
| MX2014008699A (es) | 2012-01-18 | 2014-11-21 | Genentech Inc | Metodos para utilizar moduladores de fgf19. |
| PE20141561A1 (es) | 2012-01-18 | 2014-11-12 | Genentech Inc | Anticuerpos anti-lrp5 y metodos de uso |
| CN104105711B (zh) | 2012-02-10 | 2018-11-30 | 弗·哈夫曼-拉罗切有限公司 | 单链抗体及其他异多聚体 |
| WO2013120056A1 (en) | 2012-02-11 | 2013-08-15 | Genentech, Inc. | R-spondin translocations and methods using the same |
| WO2013120929A1 (en) | 2012-02-15 | 2013-08-22 | F. Hoffmann-La Roche Ag | Fc-receptor based affinity chromatography |
| CA2865082A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Diagnosis and treatments relating to her3 inhibitors |
| AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| HK1206601A1 (en) | 2012-04-02 | 2016-01-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| RU2014148162A (ru) | 2012-05-01 | 2016-06-20 | Дженентек, Инк. | Анти-pmel17 антитела и их иммуноконъюгаты |
| WO2013170191A1 (en) | 2012-05-11 | 2013-11-14 | Genentech, Inc. | Methods of using antagonists of nad biosynthesis from nicotinamide |
| CA2873646C (en) | 2012-05-18 | 2022-04-26 | Genentech, Inc. | High-concentration monoclonal antibody formulations |
| KR102031317B1 (ko) | 2012-05-21 | 2019-10-14 | 제넨테크, 인크. | 혈액-뇌 장벽 수송의 안전성을 개선하는 방법 |
| KR101843614B1 (ko) | 2012-05-23 | 2018-03-29 | 제넨테크, 인크. | 치료제의 선택 방법 |
| US9266961B2 (en) | 2012-06-15 | 2016-02-23 | Genentech, Inc. | Anti-PCSK9 antibodies, formulations, dosing, and methods of use |
| RU2015101699A (ru) | 2012-06-21 | 2016-08-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Слитые полипептиды и конъюгаты полипептида лиганда рецептора инкретина и fc-области с измененной fc-эффекторной функцией |
| EP2867254B1 (en) | 2012-06-27 | 2017-10-25 | F. Hoffmann-La Roche AG | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| US20140004121A1 (en) | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
| KR20150023889A (ko) | 2012-06-27 | 2015-03-05 | 에프. 호프만-라 로슈 아게 | 2 개 이상의 상이한 결합 단위를 함유하는 맞춤-제작된 고도로 선별적이고 다중-특이적인 표적화 단위의 선별 및 제조 방법 및 이의 용도 |
| ES2600154T3 (es) | 2012-07-04 | 2017-02-07 | F. Hoffmann-La Roche Ag | Anticuerpos antiteofilina y métodos de uso |
| CA2871112C (en) | 2012-07-04 | 2020-05-12 | F. Hoffmann-La Roche Ag | Covalently linked antigen-antibody conjugates |
| BR112014030844A2 (pt) | 2012-07-04 | 2019-10-15 | Hoffmann La Roche | anticorpo anti-biotina humanizado, formulação farmacêutica e uso do anticorpo |
| EP3578660A1 (en) | 2012-07-05 | 2019-12-11 | F. Hoffmann-La Roche AG | Expression and secretion system |
| EP2869847B1 (en) | 2012-07-09 | 2017-12-06 | Genentech, Inc. | Immunoconjugates comprising anti-cd79b antibodies |
| HK1209043A1 (en) | 2012-07-09 | 2016-03-24 | 基因泰克公司 | Immunoconjugates comprising anti-cd22 antibodies |
| BR112015000439A2 (pt) | 2012-07-09 | 2017-12-19 | Genentech Inc | imunoconjugado , formulação farmacêutica e métodos de tratamento de um indivíduo e de inibição da proliferação |
| US20140030280A1 (en) | 2012-07-09 | 2014-01-30 | Genentech, Inc. | Anti-cd79b antibodies and immunoconjugates |
| PE20150361A1 (es) | 2012-07-13 | 2015-03-14 | Roche Glycart Ag | Anticuerpos biespecificos anti-vegf/anti-ang-2 y su utilizacion en el tratamiento de enfermedades vasculares oculares |
| CA2872195A1 (en) | 2012-08-07 | 2014-02-13 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
| EP2885311B1 (en) | 2012-08-18 | 2020-01-01 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| US9547009B2 (en) | 2012-08-21 | 2017-01-17 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| KR20150039798A (ko) | 2012-08-29 | 2015-04-13 | 에프. 호프만-라 로슈 아게 | 혈액 뇌 장벽 셔틀 |
| HK1212240A1 (en) | 2012-09-07 | 2016-06-10 | 吉宁特有限公司 | Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor |
| EP2905290B1 (en) | 2012-10-05 | 2019-12-04 | Kyowa Kirin Co., Ltd. | Heterodimeric protein composition |
| EP2904016B1 (en) | 2012-10-08 | 2018-11-14 | Roche Glycart AG | Fc-free antibodies comprising two fab-fragments and methods of use |
| EP2727943A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Trispecific antibodies against human EGFR, HER2 and HER3 |
| EP2914621B1 (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
| AU2013337264B2 (en) | 2012-11-05 | 2018-03-08 | Foundation Medicine, Inc. | Novel fusion molecules and uses thereof |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| EP2914629A1 (en) | 2012-11-05 | 2015-09-09 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| AR093378A1 (es) | 2012-11-08 | 2015-06-03 | Hoffmann La Roche | PROTEINAS LIGANTES DE ANTIGENO HER3 DE UNION A LA HORQUILLA b DE HER3 |
| BR112015010817A8 (pt) | 2012-11-13 | 2018-01-23 | Genentech Inc | anticorpos anti-hemaglutinina isolado, método de tratamento, inibição ou prevenção de infecções, composição, composição farmacêutica, ácido nucleico isolado, célula hospedeira, método de produção de anticorpos e uso do anticorpo anti-hemaglutinina |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| JP6461808B2 (ja) | 2012-12-17 | 2019-01-30 | ラボラトワール フランセ ドゥ フラクションマン エ デ バイオテクノロジーズLaboratoire Francais Du Fractionnement Et Des Biotechnologies | 炎症および細菌感染症処置におけるモノクローナル抗体の使用 |
| WO2014096015A1 (en) | 2012-12-21 | 2014-06-26 | F. Hoffmann-La Roche Ag | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
| US20140194368A1 (en) * | 2013-01-04 | 2014-07-10 | Beech Tree Labs, Inc. | Method of Treating Cancer by Administration of Low Levels of Heat Shock Protein 70 (HSP70) |
| AR094403A1 (es) | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
| RU2519546C1 (ru) * | 2013-01-16 | 2014-06-10 | Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") | КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а |
| AU2014207342C1 (en) | 2013-01-18 | 2019-04-04 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
| WO2014116749A1 (en) | 2013-01-23 | 2014-07-31 | Genentech, Inc. | Anti-hcv antibodies and methods of using thereof |
| AU2014213009B2 (en) | 2013-02-01 | 2019-01-03 | Kira Biotech Pty Limited | Anti-CD83 antibodies and use thereof |
| AU2014214530B2 (en) | 2013-02-07 | 2014-10-16 | Csl Limited | IL-11R binding proteins and uses thereof |
| JP2016508515A (ja) | 2013-02-13 | 2016-03-22 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies | 高ガラクトシル化抗TNF−α抗体およびその使用 |
| WO2014128235A1 (en) | 2013-02-22 | 2014-08-28 | F. Hoffmann-La Roche Ag | Methods of treating cancer and preventing drug resistance |
| CN104936987A (zh) | 2013-02-26 | 2015-09-23 | 罗切格利卡特公司 | 抗mcsp抗体 |
| KR20180023035A (ko) | 2013-02-26 | 2018-03-06 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
| EP3444278A1 (en) | 2013-02-26 | 2019-02-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| HK1213180A1 (zh) | 2013-03-06 | 2016-06-30 | 豪夫迈‧罗氏有限公司 | 治疗和预防癌症药物抗性的方法 |
| EP2968504B1 (en) * | 2013-03-12 | 2019-12-18 | University Of Utah Research Foundation | Compositions and methods for inducing apoptosis |
| NZ711567A (en) | 2013-03-13 | 2020-04-24 | Genentech Inc | Antibody formulations |
| JP2016515132A (ja) | 2013-03-14 | 2016-05-26 | ジェネンテック, インコーポレイテッド | Mek阻害剤化合物のher3/egfr阻害剤化合物との組み合わせ及び使用方法 |
| AU2014244424A1 (en) | 2013-03-14 | 2015-08-27 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| HK1220916A1 (zh) | 2013-03-14 | 2017-05-19 | 基因泰克公司 | 治疗癌症和预防癌症药物抗性的方法 |
| US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| RU2015143437A (ru) | 2013-03-15 | 2017-04-27 | Дженентек, Инк. | Способы лечения рака и предотвращения устойчивости к лекарственным препаратам для лечения рака |
| MX2015012326A (es) | 2013-03-15 | 2016-03-08 | Genentech Inc | Anticuerpos anti-crth2 y su uso. |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| RS57393B1 (sr) | 2013-03-15 | 2018-09-28 | Hoffmann La Roche | Il-22 polipeptiidi i il-22 fuzioni proteini i metode za njihovu upotrebu |
| KR20150131269A (ko) | 2013-03-15 | 2015-11-24 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| ES2847383T3 (es) | 2013-03-15 | 2021-08-03 | Atyr Pharma Inc | Conjugados de Fc-histidil-ARNt sintetasa |
| EP2970452A2 (en) | 2013-03-15 | 2016-01-20 | AC Immune S.A. | Anti-tau antibodies and methods of use |
| MX2015011444A (es) | 2013-03-15 | 2015-12-16 | Genentech Inc | Composiciones y metodos para el diagnostico y tratamiento del cancer hepatico. |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| SG11201508910WA (en) | 2013-04-29 | 2015-11-27 | Hoffmann La Roche | Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases |
| CN105164157B (zh) | 2013-04-29 | 2024-05-28 | 豪夫迈·罗氏有限公司 | Fc-受体结合的修饰的非对称抗体及使用方法 |
| JP2016528167A (ja) | 2013-04-29 | 2016-09-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ヒトFcRn結合改変抗体及び使用方法 |
| MY192404A (en) * | 2013-05-02 | 2022-08-19 | Hoffmann La Roche | Combination therapy of an afucosylated cd20 antibody with a cd22 antibody-drug conjugate |
| PL2992016T3 (pl) * | 2013-05-02 | 2018-02-28 | F.Hoffmann-La Roche Ag | Leczenie skojarzone niefukozylowanym przeciwciałem anty-CD20 z koniugatem przeciwciało anty-CD79b-lek |
| IL242088B2 (en) | 2013-05-20 | 2023-12-01 | Genentech Inc | Anti-transferrin receptor antibodies and methods of use |
| US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
| US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
| ME03476B (me) | 2013-08-01 | 2020-01-20 | Five Prime Therapeutics Inc | Nefukozilisana anti-fgfr2iiib antitijela |
| US20150093399A1 (en) | 2013-08-28 | 2015-04-02 | Bioasis Technologies, Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
| WO2015035337A1 (en) | 2013-09-06 | 2015-03-12 | Academia Sinica | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS |
| KR20160055252A (ko) | 2013-09-17 | 2016-05-17 | 제넨테크, 인크. | 항-lgr5 항체의 사용 방법 |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
| RS60938B1 (sr) | 2013-10-02 | 2020-11-30 | Medimmune Llc | Neutrališuća antitela na grip a i njihova upotreba |
| WO2015051214A1 (en) | 2013-10-03 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| BR112016007635A2 (pt) | 2013-10-11 | 2017-09-12 | Genentech Inc | inibidores de nsp4 e métodos de uso |
| KR20160044060A (ko) | 2013-10-11 | 2016-04-22 | 에프. 호프만-라 로슈 아게 | 다중특이적 도메인 교환된 통상의 가변 경쇄 항체 |
| ES2960807T3 (es) | 2013-10-11 | 2024-03-06 | Us Health | Anticuerpos contra TEM8 y su uso |
| WO2015058132A2 (en) | 2013-10-18 | 2015-04-23 | Genentech, Inc. | Anti-rspo antibodies and methods of use |
| BR112016008694A2 (pt) | 2013-10-23 | 2017-10-03 | Genentech Inc | Métodos de previsão da reação de pacientes com asma, de previsão da capacidade de reação de pacientes com asma, de identificação de pacientes com asma, de tratamento de pacientes portadores de asma e de tratamento de asma, uso de um kit e kit |
| EP3063275B1 (en) | 2013-10-31 | 2019-09-25 | Resolve Therapeutics, LLC | Therapeutic nuclease-albumin fusions and methods |
| SI3071597T1 (sl) | 2013-11-21 | 2020-11-30 | F. Hoffmann-La Roche Ag | Anti alfa-sinukleinska protitelesa in postopki uporabe |
| WO2015082446A1 (en) | 2013-12-02 | 2015-06-11 | F. Hoffmann-La Roche Ag | Treatment of cancer using an anti-cdcp1 antibody and a taxane |
| HRP20192052T1 (hr) | 2013-12-09 | 2020-02-07 | Allakos Inc. | Protutijela anti-siglec-8 te njihovi postupci i uporabe |
| EP3461845B1 (en) | 2013-12-13 | 2020-09-16 | Genentech, Inc. | Anti-cd33 antibodies and immunoconjugates |
| BR112016013963A2 (pt) | 2013-12-17 | 2017-10-10 | Genentech Inc | terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1 |
| CA2933881A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
| PE20210107A1 (es) | 2013-12-17 | 2021-01-19 | Genentech Inc | Anticuerpos anti-cd3 y metodos de uso |
| FI3083686T4 (fi) | 2013-12-17 | 2023-05-09 | Menetelmiä syöpien hoitamiseksi käyttäen pd-1-akselia sitovia antagonisteja ja taksaaneja | |
| TWI728373B (zh) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | 抗體及使用方法 |
| BR112016014945A2 (pt) | 2014-01-03 | 2018-01-23 | F. Hoffmann-La Roche Ag | conjugado, formulação farmacêutica e uso |
| WO2015103549A1 (en) | 2014-01-03 | 2015-07-09 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| EP3089996B1 (en) | 2014-01-03 | 2021-07-28 | F. Hoffmann-La Roche AG | Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles |
| EP3089758B1 (en) | 2014-01-03 | 2021-01-27 | F.Hoffmann-La Roche Ag | Covalently linked helicar-anti-helicar antibody conjugates and uses thereof |
| BR112016015589A2 (pt) | 2014-01-06 | 2017-10-31 | Hoffmann La Roche | módulos de trânsito monovalentes para a barreira hematoencefálica |
| EP3835318B1 (en) | 2014-01-15 | 2025-10-29 | F. Hoffmann-La Roche AG | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
| US9982041B2 (en) | 2014-01-16 | 2018-05-29 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| AU2015209154A1 (en) | 2014-01-24 | 2017-02-16 | Genentech, Inc. | Methods of using anti-STEAP1 antibodies and immunoconjugates |
| DK3102197T3 (en) | 2014-02-04 | 2018-11-19 | Genentech Inc | Smoothened mutant and methods for its use |
| EP3718563A1 (en) | 2014-02-08 | 2020-10-07 | F. Hoffmann-La Roche AG | Methods of treating alzheimer's disease |
| KR102476641B1 (ko) | 2014-02-08 | 2022-12-09 | 제넨테크, 인크. | 알츠하이머병의 치료 방법 |
| CA2936565C (en) | 2014-02-12 | 2020-08-11 | Genentech, Inc. | Anti-jagged1 antibodies and methods of use |
| MX2016010729A (es) | 2014-02-21 | 2016-10-26 | Genentech Inc | Anticuerpos biespecificos anti-il-13 / il-17 y sus usos. |
| WO2015131155A1 (en) | 2014-02-28 | 2015-09-03 | Allakos Inc. | Methods and compositions for treating siglec-8 associated diseases |
| WO2015139046A1 (en) | 2014-03-14 | 2015-09-17 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| BR112016023417A2 (pt) | 2014-03-21 | 2019-04-16 | F. Hoffmann-La Roche Ag | predição in vitro de meia-vida in vivo |
| US20170107294A1 (en) | 2014-03-21 | 2017-04-20 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof |
| CN107002119A (zh) | 2014-03-24 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联 |
| EP3129767B1 (en) | 2014-03-27 | 2021-09-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
| PE20161571A1 (es) | 2014-03-31 | 2017-02-07 | Genentech Inc | Anticuerpos anti-ox40 y metodos de uso |
| JP6588461B2 (ja) | 2014-03-31 | 2019-10-09 | ジェネンテック, インコーポレイテッド | 抗血管新生剤及びox40結合アゴニストを含む併用療法 |
| HK1232127A1 (zh) | 2014-04-11 | 2018-01-05 | Medimmune, Llc | 双特异性her2抗体 |
| WO2015164615A1 (en) | 2014-04-24 | 2015-10-29 | University Of Oslo | Anti-gluten antibodies and uses thereof |
| EP3145952A2 (en) | 2014-05-22 | 2017-03-29 | Genentech, Inc. | Anti-gpc3 antibodies and immunoconjugates |
| KR20170005016A (ko) | 2014-05-23 | 2017-01-11 | 제넨테크, 인크. | MiT 바이오마커 및 그의 사용 방법 |
| CN106573971A (zh) | 2014-05-27 | 2017-04-19 | 中央研究院 | 抗cd20醣抗体及其用途 |
| AU2015267051B2 (en) | 2014-05-27 | 2022-03-17 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CA2950440A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| CN106714829A (zh) | 2014-05-28 | 2017-05-24 | 中央研究院 | 抗TNF‑α醣抗体及其用途 |
| AU2015266664B2 (en) | 2014-05-30 | 2020-04-30 | Shanghai Henlius Biotech, Inc. | Anti-epidermal growth factor receptor (EGFR) antibodies |
| MX2016016233A (es) | 2014-06-11 | 2017-03-31 | Genentech Inc | Anticuerpos anti-lgr5 y sus usos. |
| JP2017517552A (ja) | 2014-06-13 | 2017-06-29 | ジェネンテック, インコーポレイテッド | 抗癌剤耐性の治療及び防止方法 |
| CA2947504A1 (en) | 2014-06-26 | 2015-12-30 | F. Hoffmann-La Roche Ag | Anti-brdu antibodies and methods of use |
| BR112017000497B1 (pt) | 2014-07-11 | 2023-12-26 | Ventana Medical Systems, Inc | Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1 |
| BR112017000130A2 (pt) | 2014-07-11 | 2018-01-09 | Genentech Inc | método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer |
| DK3177643T3 (da) * | 2014-08-04 | 2019-07-15 | Hoffmann La Roche | Bispecifikke T-celle-aktiverende antigenbindende molekyler |
| RU2764074C2 (ru) | 2014-08-28 | 2022-01-13 | Байоатла, Ллк | Условно активные химерные антигенные рецепторы для модифицированных т-клеток |
| TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| US9879042B2 (en) | 2014-09-08 | 2018-01-30 | Academia Sinica | Human iNKT cell activation using glycolipids |
| EP3567056A1 (en) * | 2014-09-10 | 2019-11-13 | F. Hoffmann-La Roche AG | Galactoengineered immunoglobulin 1 antibodies |
| EP3191518B1 (en) | 2014-09-12 | 2020-01-15 | Genentech, Inc. | Anti-b7-h4 antibodies and immunoconjugates |
| KR102508173B1 (ko) | 2014-09-12 | 2023-03-10 | 제넨테크, 인크. | 항-her2 항체 및 면역콘주게이트 |
| US9751946B2 (en) | 2014-09-12 | 2017-09-05 | Genentech, Inc. | Anti-CLL-1 antibodies and immunoconjugates |
| EP3193932B1 (en) | 2014-09-15 | 2023-04-26 | F. Hoffmann-La Roche AG | Antibody formulations |
| HK1243629A1 (zh) | 2014-09-17 | 2018-07-20 | 基因泰克公司 | 包含抗her2抗体和吡咯并苯并二氮杂䓬的免疫缀合物 |
| EP3689910A3 (en) | 2014-09-23 | 2020-12-02 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
| CN107074938A (zh) | 2014-10-16 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 抗‑α‑突触核蛋白抗体和使用方法 |
| EP3209695A4 (en) | 2014-10-23 | 2018-05-30 | DendroCyte BioTech Pty Ltd | Cd83 binding proteins and uses thereof |
| WO2016070001A1 (en) | 2014-10-31 | 2016-05-06 | Jounce Therapeutics, Inc. | Methods of treating conditions with antibodies that bind b7-h4 |
| CA2966523A1 (en) | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Assays for detecting t cell immune subsets and methods of use thereof |
| SG11201703521UA (en) | 2014-11-03 | 2017-05-30 | Genentech Inc | Methods and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment |
| KR20170080675A (ko) | 2014-11-05 | 2017-07-10 | 제넨테크, 인크. | 항-fgfr2/3 항체 및 이의 이용 방법 |
| KR20170076697A (ko) | 2014-11-06 | 2017-07-04 | 에프. 호프만-라 로슈 아게 | 개질된 FCRN-결합 특성 및 단백질 A-결합 특성을 가진 Fc-영역 변이체 |
| KR20170072343A (ko) | 2014-11-06 | 2017-06-26 | 제넨테크, 인크. | Ox40 결합 효능제 및 tigit 억제제를 포함하는 병용 요법 |
| HUE045466T2 (hu) | 2014-11-06 | 2019-12-30 | Hoffmann La Roche | Fc-régió-variánsok módosított FcRn-kötéssel és alkalmazási eljárások |
| EP3552488A1 (en) | 2014-11-10 | 2019-10-16 | F. Hoffmann-La Roche AG | Animal model for nephropathy and agents for treating the same |
| MX2017006094A (es) | 2014-11-10 | 2017-07-19 | Genentech Inc | Anticuerpos anti-interleucina-33 y sus usos. |
| TWI757803B (zh) | 2014-11-14 | 2022-03-11 | 瑞士商赫孚孟拉羅股份公司 | 包含tnf家族配位三聚體之抗原結合分子 |
| EP3875481B1 (en) | 2014-11-14 | 2025-01-22 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use |
| EP3221360A1 (en) | 2014-11-17 | 2017-09-27 | F. Hoffmann-La Roche AG | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| US10508151B2 (en) | 2014-11-19 | 2019-12-17 | Genentech, Inc. | Anti-transferrin receptor antibodies and methods of use |
| JP6993228B2 (ja) | 2014-11-19 | 2022-03-03 | ジェネンテック, インコーポレイテッド | 抗トランスフェリン受容体/抗bace1多重特異性抗体および使用方法 |
| CN107108745B (zh) | 2014-11-19 | 2021-01-12 | 基因泰克公司 | 抗bace1的抗体和其用于神经疾病免疫疗法的用途 |
| DK3221357T3 (da) | 2014-11-20 | 2020-08-10 | Hoffmann La Roche | Fælles letkæder og fremgangsmåder til anvendelse |
| DK4141032T3 (da) | 2014-11-20 | 2024-08-05 | Hoffmann La Roche | Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler og PD-1-aksebindende antagonister |
| DK3221356T3 (da) | 2014-11-20 | 2020-11-02 | Hoffmann La Roche | T-celleaktiverende, bispecifikke, antigenbindende molekyler mod folr1 og cd3 |
| WO2016087416A1 (en) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
| SG11201704449VA (en) | 2014-12-05 | 2017-06-29 | Genentech Inc | ANTI-CD79b ANTIBODIES AND METHODS OF USE |
| EP3230317A2 (en) | 2014-12-10 | 2017-10-18 | F. Hoffmann-La Roche AG | Blood brain barrier receptor antibodies and methods of use |
| AR103162A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-c5 y métodos para su uso |
| IL278014B2 (en) | 2014-12-19 | 2023-10-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variable FC regions and methods of use |
| US20160200815A1 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| MX2017009254A (es) | 2015-01-16 | 2017-10-12 | Juno Therapeutics Inc | Anticuerpos y receptores de antigeno quimerico especificos para ror1. |
| JP2018511557A (ja) | 2015-01-22 | 2018-04-26 | 中外製薬株式会社 | 2種以上の抗c5抗体の組み合わせおよび使用方法 |
| AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| CA2975875A1 (en) | 2015-02-04 | 2016-08-11 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| SG10201907215QA (en) | 2015-02-05 | 2019-09-27 | Chugai Pharmaceutical Co Ltd | Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof |
| WO2016138160A1 (en) | 2015-02-24 | 2016-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use |
| CA2977285A1 (en) | 2015-03-16 | 2016-09-22 | F. Hoffmann-La Roche Ag | Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases |
| WO2016146833A1 (en) | 2015-03-19 | 2016-09-22 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance |
| PT3271389T (pt) | 2015-03-20 | 2020-05-13 | Us Health | Anticorpos neutralizantes dirigidos contra a gp120 e sua utilização |
| AU2016235362B2 (en) | 2015-03-23 | 2021-12-16 | Jounce Therapeutics, Inc. | Antibodies to ICOS |
| EP3628688A1 (en) | 2015-03-23 | 2020-04-01 | Bayer Pharma Aktiengesellschaft | Anti-ceacam6 antibodies and uses thereof |
| RU2021124437A (ru) | 2015-04-03 | 2021-09-29 | Еурека Терапьютикс, Инк. | Конструкции, направленные на комплексы пептида afp/mhc, и виды их использования |
| CN115932273A (zh) | 2015-04-24 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 鉴定包含结合多肽的细菌的方法 |
| WO2016174917A1 (ja) * | 2015-04-30 | 2016-11-03 | 富士フイルム株式会社 | 装飾シート |
| CN107709363A (zh) | 2015-05-01 | 2018-02-16 | 基因泰克公司 | 掩蔽抗cd3抗体和使用方法 |
| WO2016179194A1 (en) | 2015-05-04 | 2016-11-10 | Jounce Therapeutics, Inc. | Lilra3 and method of using the same |
| EP4238994A3 (en) | 2015-05-11 | 2024-02-07 | F. Hoffmann-La Roche AG | Compositions and methods of treating lupus nephritis |
| RS61152B2 (sr) | 2015-05-12 | 2024-06-28 | Hoffmann La Roche | Terapeutski i dijagnostički postupci za lečenje raka |
| WO2016196343A1 (en) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Humanized anti-ebola virus glycoprotein antibodies and methods of use |
| HK1248773A1 (zh) | 2015-05-29 | 2018-10-19 | 豪夫迈‧罗氏有限公司 | 用於癌症的治疗和诊断方法 |
| JP2018516933A (ja) | 2015-06-02 | 2018-06-28 | ジェネンテック, インコーポレイテッド | 抗il−34抗体を使用して神経学的疾患を治療するための組成物及び方法 |
| WO2016196975A1 (en) | 2015-06-03 | 2016-12-08 | The United States Of America, As Represented By The Secretary Department Of Health & Human Services | Neutralizing antibodies to hiv-1 env and their use |
| EA033821B1 (ru) | 2015-06-04 | 2019-11-29 | Ospedale San Raffaele Srl | Применение ингибитора оси igfbp3/tmem219 для лечения диабета |
| CN107921094B (zh) | 2015-06-04 | 2022-03-01 | 圣拉斐尔医院有限公司 | Igfbp3及其用途 |
| EP4465050A3 (en) | 2015-06-05 | 2025-06-11 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| JP2018521019A (ja) | 2015-06-08 | 2018-08-02 | ジェネンテック, インコーポレイテッド | 抗ox40抗体を使用して癌を治療する方法 |
| JP2018518483A (ja) | 2015-06-08 | 2018-07-12 | ジェネンテック, インコーポレイテッド | 抗ox40抗体及びpd−1軸結合アンタゴニストを使用して癌を治療する方法 |
| JP2018524295A (ja) | 2015-06-15 | 2018-08-30 | ジェネンテック, インコーポレイテッド | 抗体及び免疫複合体 |
| EP3310378B1 (en) | 2015-06-16 | 2024-01-24 | F. Hoffmann-La Roche AG | Anti-cll-1 antibodies and methods of use |
| CN107849132B (zh) | 2015-06-16 | 2022-03-08 | 豪夫迈·罗氏有限公司 | 人源化的和亲和力成熟的针对FcRH5的抗体和使用方法 |
| EP3916018A1 (en) | 2015-06-16 | 2021-12-01 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| JP2018524312A (ja) | 2015-06-17 | 2018-08-30 | ジェネンテック, インコーポレイテッド | 抗her2抗体及び使用方法 |
| WO2016205567A1 (en) | 2015-06-17 | 2016-12-22 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| IL256080B2 (en) | 2015-06-17 | 2025-06-01 | Genentech Inc | Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes |
| EP3313890A1 (en) | 2015-06-24 | 2018-05-02 | H. Hoffnabb-La Roche Ag | Trispecific antibodies specific for her2 and a blood brain barrier receptor and methods of use |
| UA123053C2 (uk) | 2015-06-24 | 2021-02-10 | Ф. Хоффманн-Ля Рош Аг | Антитіло до рецептора трансферину зі спеціально підібраною афінністю |
| EP3108897A1 (en) | 2015-06-24 | 2016-12-28 | F. Hoffmann-La Roche AG | Antibodies against human csf-1r for use in inducing lymphocytosis in lymphomas or leukemias |
| KR20180012873A (ko) * | 2015-06-24 | 2018-02-06 | 에프. 호프만-라 로슈 아게 | 림프종 또는 백혈병에서 림프구증가증의 유도에 사용하기 위한 인간 csf-1r에 대한 항체 |
| CA2990305A1 (en) | 2015-06-26 | 2016-12-29 | Mab Discovery Gmbh | Monoclonal anti-il-1racp antibodies |
| EP3514174B1 (en) | 2015-06-29 | 2021-03-31 | Ventana Medical Systems, Inc. | Materials and methods for performing histochemical assays for human pro-epiregulin and amphiregulin |
| CA2989936A1 (en) | 2015-06-29 | 2017-01-05 | Genentech, Inc. | Type ii anti-cd20 antibody for use in organ transplantation |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| EP3932953A1 (en) | 2015-08-28 | 2022-01-05 | F. Hoffmann-La Roche AG | Anti-hypusine antibodies and uses thereof |
| JP6904947B2 (ja) | 2015-09-22 | 2021-07-21 | スプリング バイオサイエンス コーポレーション | 抗ox40抗体及びその診断用途 |
| KR102725051B1 (ko) | 2015-09-23 | 2024-11-04 | 제넨테크, 인크. | 항-vegf 항체의 최적화된 변이체들 |
| CN108289954B (zh) | 2015-09-24 | 2022-05-31 | 阿布维特罗有限责任公司 | Hiv抗体组合物和使用方法 |
| KR20230125094A (ko) | 2015-09-25 | 2023-08-28 | 제넨테크, 인크. | 항-tigit 항체 및 이의 이용 방법 |
| WO2017058944A1 (en) | 2015-09-29 | 2017-04-06 | Amgen Inc. | Asgr inhibitors |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| MA43023A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Anticorps de récepteur de la transferrine humaine/anti-humaine cd20 bispécifique et leurs procédés d'utilisation |
| RS62258B1 (sr) | 2015-10-02 | 2021-09-30 | Hoffmann La Roche | Bispecifična antitela specifična za pd1 i tim3 |
| KR20180073561A (ko) | 2015-10-02 | 2018-07-02 | 에프. 호프만-라 로슈 아게 | 이중특이적 항-ceaxcd3 t 세포 활성화 항원 결합 분자 |
| EP3150636A1 (en) | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Tetravalent multispecific antibodies |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| KR20180053674A (ko) | 2015-10-02 | 2018-05-23 | 에프. 호프만-라 로슈 아게 | 공자극 tnf 수용체에 특이적인 이중특이성 항체 |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| WO2017062748A1 (en) | 2015-10-07 | 2017-04-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Il-7r-alpha specific antibodies for treating acute lymphoblastic leukemia |
| EP3359568B1 (en) | 2015-10-07 | 2022-03-09 | F. Hoffmann-La Roche AG | Bispecific antibodies with tetravalency for a costimulatory tnf receptor |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| KR20180066236A (ko) | 2015-10-22 | 2018-06-18 | 조운스 테라퓨틱스, 인크. | Icos 발현을 계측하기 위한 유전자 특질 |
| EP3184547A1 (en) | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anti-tpbg antibodies and methods of use |
| JP6949016B2 (ja) | 2015-10-29 | 2021-10-13 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗バリアントFc領域抗体および使用法 |
| WO2017075173A2 (en) | 2015-10-30 | 2017-05-04 | Genentech, Inc. | Anti-factor d antibodies and conjugates |
| RU2750285C2 (ru) | 2015-10-30 | 2021-06-25 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ НtrА1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| WO2017079479A1 (en) | 2015-11-03 | 2017-05-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human | Neutralizing antibodies to hiv-1 gp41 and their use |
| CN108602884B (zh) | 2015-11-08 | 2024-06-25 | 豪夫迈·罗氏有限公司 | 筛选多特异性抗体的方法 |
| KR20250034528A (ko) | 2015-11-23 | 2025-03-11 | 파이브 프라임 테라퓨틱스, 인크. | 암 치료에서의 단독의, 또는 면역 자극제와 병용한, fgfr2 억제제 |
| KR102850929B1 (ko) * | 2015-12-09 | 2025-08-27 | 에프. 호프만-라 로슈 아게 | 항-약물 항체의 형성을 감소시키기 위한 ii형 항-cd20 항체 |
| EP3178848A1 (en) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
| IL259256B2 (en) | 2015-12-18 | 2023-02-01 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
| CA3002422C (en) | 2015-12-18 | 2024-04-16 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| ES2837428T3 (es) | 2016-01-08 | 2021-06-30 | Hoffmann La Roche | Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3 |
| CN114019170A (zh) | 2016-01-20 | 2022-02-08 | 基因泰克公司 | 用于阿尔茨海默氏病的高剂量治疗 |
| JP2019509721A (ja) | 2016-02-04 | 2019-04-11 | キュリス,インコーポレイテッド | 突然変異体スムースンド及びその使用方法 |
| KR102500659B1 (ko) | 2016-02-29 | 2023-02-16 | 제넨테크, 인크. | 암에 대한 치료 및 진단 방법 |
| EP3423491A1 (en) * | 2016-03-01 | 2019-01-09 | H. Hoffnabb-La Roche Ag | Obinutuzumab variants having altered cell death induction |
| KR20180114210A (ko) | 2016-03-08 | 2018-10-17 | 아카데미아 시니카 | N-글리칸의 모듈 합성 방법 및 그의 어레이 |
| EP3430054B1 (en) | 2016-03-15 | 2021-12-29 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
| JP7015244B2 (ja) | 2016-03-22 | 2022-02-02 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | プロテアーゼ活性化t細胞二重特異性分子 |
| CN108700598A (zh) | 2016-03-25 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 多路总抗体和抗体缀合的药物量化测定法 |
| SG11201807279QA (en) * | 2016-03-31 | 2018-09-27 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| US20170319688A1 (en) | 2016-04-14 | 2017-11-09 | Genentech, Inc. | Anti-rspo3 antibodies and methods of use |
| JP7503887B2 (ja) | 2016-04-15 | 2024-06-21 | ジェネンテック, インコーポレイテッド | がんを監視及び治療するための方法 |
| CN109563164A (zh) | 2016-04-15 | 2019-04-02 | 生物蛋白有限公司 | 抗axl抗体、抗体片段和它们的免疫缀合物以及其用途 |
| CA3020718A1 (en) | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Methods for monitoring and treating cancer |
| WO2017192589A1 (en) | 2016-05-02 | 2017-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to influenza ha and their use and identification |
| CR20180509A (es) | 2016-05-02 | 2019-02-15 | Hoffmann La Roche | Contorsbody - un ligante de diana monocatenario |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| JP7089483B2 (ja) | 2016-05-11 | 2022-06-22 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 修飾された抗テネイシン抗体及び使用方法 |
| WO2017194442A1 (en) | 2016-05-11 | 2017-11-16 | F. Hoffmann-La Roche Ag | Antigen binding molecules comprising a tnf family ligand trimer and a tenascin binding moiety |
| EP3243836A1 (en) | 2016-05-11 | 2017-11-15 | F. Hoffmann-La Roche AG | C-terminally fused tnf family ligand trimer-containing antigen binding molecules |
| TWI844509B (zh) | 2016-05-13 | 2024-06-11 | 美商拜奧亞特拉公司 | 抗-ror2抗體、抗體片段、其免疫結合物及其用途 |
| EP3243832A1 (en) | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| CN109313200B (zh) | 2016-05-27 | 2022-10-04 | 豪夫迈·罗氏有限公司 | 用于表征位点特异性抗体-药物缀合物的生物分析性方法 |
| EP3252078A1 (en) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer |
| AU2018276419A1 (en) | 2016-06-02 | 2019-10-17 | F. Hoffmann-La Roche Ag | Type II anti-CD20 antibody and anti-CD20/CD3 bispecific antibody for treatment of cancer |
| KR102376582B1 (ko) | 2016-06-17 | 2022-03-18 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체 및 사용 방법 |
| EP3257866A1 (en) | 2016-06-17 | 2017-12-20 | Academisch Medisch Centrum | Modified anti-tnf antibody and use thereof in the treatment of ibd |
| WO2017223405A1 (en) | 2016-06-24 | 2017-12-28 | Genentech, Inc. | Anti-polyubiquitin multispecific antibodies |
| CN109476749A (zh) * | 2016-06-30 | 2019-03-15 | 豪夫迈·罗氏有限公司 | 改良的过继性t细胞疗法 |
| DK3478830T3 (da) | 2016-07-01 | 2024-05-21 | Resolve Therapeutics Llc | Optimerede binucleasefusioner og metoder |
| JP6983824B2 (ja) | 2016-07-04 | 2021-12-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規抗体フォーマット |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| KR20230107408A (ko) | 2016-07-29 | 2023-07-14 | 주노 쎄러퓨티크스 인코퍼레이티드 | 항-cd19 항체에 대한 항-이디오타입 항체 |
| CN109415444B (zh) | 2016-07-29 | 2024-03-01 | 中外制药株式会社 | 显示增加的备选fviii辅因子功能活性的双特异性抗体 |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| JP7250674B2 (ja) | 2016-08-08 | 2023-04-03 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | がんの治療及び診断方法 |
| US10538592B2 (en) | 2016-08-22 | 2020-01-21 | Cho Pharma, Inc. | Antibodies, binding fragments, and methods of use |
| CN107384932B (zh) | 2016-08-31 | 2020-10-20 | 北京天广实生物技术股份有限公司 | 抗人cd20人源化单克隆抗体mil62、其制备方法及用途 |
| WO2018045379A1 (en) | 2016-09-02 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Composition and methods of treating b cell disorders |
| EP3510046A4 (en) | 2016-09-07 | 2020-05-06 | The Regents of the University of California | ANTIBODIES AGAINST OXIDATION-SPECIFIC EPITOPES |
| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
| CN116731197A (zh) | 2016-09-19 | 2023-09-12 | 豪夫迈·罗氏有限公司 | 基于补体因子的亲和层析 |
| HRP20231015T1 (hr) | 2016-09-23 | 2023-12-08 | F. Hoffmann-La Roche Ag | Upotreba antagonista il-13 u liječenju atopičnog dermatitisa |
| ES2897217T3 (es) | 2016-09-30 | 2022-02-28 | Hoffmann La Roche | Anticuerpos biespecíficos frente a p95HER2 |
| KR20190062505A (ko) | 2016-10-03 | 2019-06-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Hpv-특이적 결합 분자 |
| EP3522933B1 (en) | 2016-10-05 | 2021-12-15 | F. Hoffmann-La Roche AG | Methods for preparing antibody drug conjugates |
| MX2019003934A (es) | 2016-10-06 | 2019-07-10 | Genentech Inc | Métodos terapéuticos y de diagnóstico para el cáncer. |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| JP2019535250A (ja) | 2016-10-29 | 2019-12-12 | ジェネンテック, インコーポレイテッド | 抗mic抗体及び使用方法 |
| CN110392694B (zh) | 2016-11-02 | 2023-08-04 | 震动疗法股份有限公司 | 针对pd-1的抗体及其用途 |
| CN109923128A (zh) | 2016-11-15 | 2019-06-21 | 基因泰克公司 | 用于用抗cd20/抗cd3双特异性抗体进行治疗的给药 |
| JOP20190100A1 (ar) | 2016-11-19 | 2019-05-01 | Potenza Therapeutics Inc | بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها |
| WO2018091724A1 (en) | 2016-11-21 | 2018-05-24 | Cureab Gmbh | Anti-gp73 antibodies and immunoconjugates |
| EP3551220B1 (en) | 2016-12-07 | 2025-01-29 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| CN110248959B (zh) | 2016-12-07 | 2023-06-30 | 基因泰克公司 | 抗tau抗体和使用方法 |
| EP3551663A1 (en) | 2016-12-12 | 2019-10-16 | H. Hoffnabb-La Roche Ag | Methods of treating cancer using anti-pd-l1 antibodies and antiandrogens |
| CN110087682B (zh) | 2016-12-19 | 2023-12-15 | 豪夫迈·罗氏有限公司 | 用靶向性4-1bb(cd137)激动剂的组合疗法 |
| JP7247091B2 (ja) | 2016-12-20 | 2023-03-28 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗cd20/抗cd3二重特異性抗体と4-1bb(cd137)アゴニストの併用療法 |
| JOP20190134A1 (ar) | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
| EP3565843A1 (en) | 2017-01-03 | 2019-11-13 | H. Hoffnabb-La Roche Ag | Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9 |
| TW201825515A (zh) | 2017-01-04 | 2018-07-16 | 美商伊繆諾金公司 | Met抗體以及其免疫結合物及用途 |
| TW201831517A (zh) | 2017-01-12 | 2018-09-01 | 美商優瑞科生物技術公司 | 靶向組織蛋白h3肽/mhc複合體之構築體及其用途 |
| EP3580235B1 (en) | 2017-02-10 | 2024-05-01 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
| TWI778018B (zh) | 2017-02-10 | 2022-09-21 | 美商建南德克公司 | 抗類胰蛋白酶抗體、其組合物及其用途 |
| ES2953595T3 (es) | 2017-03-01 | 2023-11-14 | Hoffmann La Roche | Procedimientos diagnósticos y terapéuticos para el cáncer |
| AR111249A1 (es) | 2017-03-22 | 2019-06-19 | Genentech Inc | Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares |
| KR20190133162A (ko) | 2017-03-28 | 2019-12-02 | 제넨테크, 인크. | 신경퇴행성 질병의 치료 방법 |
| JP7196094B2 (ja) | 2017-03-29 | 2022-12-26 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 共刺激tnf受容体のための二重特異性抗原結合分子 |
| JP7205995B2 (ja) | 2017-03-29 | 2023-01-17 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 共刺激性tnf受容体に対する二重特異性抗原結合分子 |
| JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
| EP3606956B1 (en) | 2017-04-04 | 2024-07-31 | F. Hoffmann-La Roche AG | Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap |
| US11285207B2 (en) | 2017-04-05 | 2022-03-29 | Hoffmann-La Roche Inc. | Bispecific antibodies specifically binding to PD1 and LAG3 |
| KR20240165484A (ko) | 2017-04-11 | 2024-11-22 | 인히브릭스 바이오사이언스, 인크. | 제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 이를 이용한 방법 |
| JP2020516253A (ja) | 2017-04-14 | 2020-06-11 | ジェネンテック, インコーポレイテッド | がんのための診断及び治療方法 |
| EP3612215B1 (en) | 2017-04-20 | 2024-08-28 | aTyr Pharma, Inc. | Compositions for treating lung inflammation |
| JP7248588B2 (ja) | 2017-04-21 | 2023-03-29 | ジェネンテック, インコーポレイテッド | 疾患の治療のためのklk5アンタゴニストの使用 |
| AU2018258049B2 (en) | 2017-04-26 | 2025-03-27 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
| KR102769634B1 (ko) | 2017-04-27 | 2025-02-19 | 테사로, 인코포레이티드 | 림프구 활성화 유전자-3 (lag-3)에 대한 항체 작용제 및 그의 용도 |
| EA201992626A1 (ru) | 2017-05-05 | 2020-04-24 | Аллакос Инк. | Способы и композиции для лечения аллергических заболеваний глаз |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| PT3624837T (pt) | 2017-05-16 | 2025-10-01 | Five Prime Therapeutics Inc | Anticorpos anti-fgfr2 em combinação com agentes quimioterapêuticos no tratamento do cancro |
| US11634488B2 (en) | 2017-07-10 | 2023-04-25 | International—Drug—Development—Biotech | Treatment of B cell malignancies using afucosylated pro-apoptotic anti-CD19 antibodies in combination with anti CD20 antibodies or chemotherapeutics |
| IL271888B2 (en) | 2017-07-21 | 2024-09-01 | Genentech Inc | Therapeutic and diagnostic methods for cancer |
| WO2019023247A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND |
| CN110869391A (zh) | 2017-07-26 | 2020-03-06 | 豪夫迈·罗氏有限公司 | 用BET抑制剂,Bcl-2抑制剂和抗CD20抗体的组合疗法 |
| CN111448210B (zh) | 2017-07-26 | 2024-05-14 | 四十七公司 | 抗SIRP-α抗体及相关方法 |
| CA3071618A1 (en) | 2017-08-08 | 2019-02-14 | F. Hoffmann-La Roche Ag | Obinutuzumab treatment of a dlbcl patient subgroup |
| CN107881160A (zh) * | 2017-08-11 | 2018-04-06 | 百奥泰生物科技(广州)有限公司 | 一种由基因组被编辑的cho宿主细胞产生的具有独特糖谱的重组抗体及其制备方法 |
| WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
| MX2020002070A (es) | 2017-08-22 | 2020-03-24 | Sanabio Llc | Receptores solubles de interferon y usos de los mismos. |
| EP4424707A3 (en) * | 2017-09-19 | 2024-11-13 | Tillotts Pharma AG | Antibody variants |
| US20200216542A1 (en) | 2017-09-20 | 2020-07-09 | Chugai Seiyaku Kabushiki Kaisha | Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent |
| EP3692063A1 (en) | 2017-10-03 | 2020-08-12 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| CN111372950B (zh) | 2017-10-12 | 2024-11-05 | 免疫苏醒公司 | Vegfr-抗体轻链融合蛋白 |
| KR20240157135A (ko) | 2017-10-19 | 2024-10-31 | 에프. 호프만-라 로슈 아게 | 오비누투주맙에 의한 cd20-양성 b 세포 림프종의 치료 |
| KR20200074997A (ko) | 2017-11-01 | 2020-06-25 | 주노 쎄러퓨티크스 인코퍼레이티드 | B-세포 성숙 항원에 특이적인 항체 및 키메릭 항원 수용체 |
| CN111246884A (zh) | 2017-11-01 | 2020-06-05 | 豪夫迈·罗氏有限公司 | 新颖的含有tnf家族配体三聚体的抗原结合分子 |
| CA3079036A1 (en) | 2017-11-01 | 2019-05-09 | F. Hoffmann-La Roche Ag | Combination therapy with targeted ox40 agonists |
| BR112020006443A2 (pt) | 2017-11-01 | 2020-09-29 | F. Hoffmann-La Roche Ag | anticorpos biespecíficos, ácido nucleico isolado, vetor ou célula hospedeira, método para produzir um anticorpo biespecífico e para tratar um indivíduo, composição farmacêutica e uso do anticorpo |
| CA3077664A1 (en) | 2017-11-06 | 2019-05-09 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| EP4640703A2 (en) | 2017-11-14 | 2025-10-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibodies and methods of use |
| JP7391839B2 (ja) | 2017-12-01 | 2023-12-05 | ファイザー・インク | 抗cxcr5抗体、その組成物及びその使用 |
| EP3723799A1 (en) | 2017-12-14 | 2020-10-21 | H. Hoffnabb-La Roche Ag | Use of a cea cd3 bispecific antibody and a pd-1 axis binding antagonist in a dosage regime to treat cancer |
| CN112204048A (zh) | 2017-12-15 | 2021-01-08 | 朱诺治疗学股份有限公司 | 抗cct5结合分子及其使用方法 |
| EP3502140A1 (en) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
| WO2019126472A1 (en) | 2017-12-22 | 2019-06-27 | Genentech, Inc. | Use of pilra binding agents for treatment of a disease |
| CN111699196A (zh) | 2017-12-22 | 2020-09-22 | 震动疗法公司 | 针对lilrb2的抗体 |
| JP7383617B2 (ja) | 2017-12-28 | 2023-11-20 | ナンジン レジェンド バイオテック カンパニー,リミテッド | Pd-l1に対する抗体及びそのバリアント |
| JP7369127B2 (ja) | 2017-12-28 | 2023-10-25 | ナンジン レジェンド バイオテック カンパニー,リミテッド | Tigitに対する単一ドメイン抗体及びその変異体 |
| WO2019136029A1 (en) | 2018-01-02 | 2019-07-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use |
| KR20200118029A (ko) | 2018-01-04 | 2020-10-14 | 아이코닉 테라퓨틱스, 인코포레이티드 | 항-조직 인자 항체, 항체-약물 결합체, 및 관련 방법 |
| CA3086879A1 (en) | 2018-01-05 | 2019-07-11 | Ac Immune Sa | Misfolded tdp-43 binding molecules |
| EP3508499A1 (en) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| KR20250114571A (ko) | 2018-01-15 | 2025-07-29 | 난징 레전드 바이오테크 씨오., 엘티디. | Pd-1에 대한 단일-도메인 항체 및 이의 변이체 |
| WO2019143636A1 (en) | 2018-01-16 | 2019-07-25 | Lakepharma, Inc. | Bispecific antibody that binds cd3 and another target |
| AR114565A1 (es) | 2018-01-26 | 2020-09-23 | Genentech Inc | Proteínas de fusión fc il-22 y métodos de uso |
| CA3088763A1 (en) | 2018-01-26 | 2019-08-01 | Genentech, Inc. | Compositions and methods of use |
| CA3081125C (en) | 2018-02-01 | 2025-09-16 | Innovent Biologics (Suzhou) Co., Ltd. | All-Human Single-Chain Variable Fragment Anti-Antigen for B Lymphocyte Maturation (BCMA), and Associated Application |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| CN118772288A (zh) | 2018-02-08 | 2024-10-15 | 豪夫迈·罗氏有限公司 | 双特异性抗原结合分子和使用方法 |
| WO2019157358A1 (en) | 2018-02-09 | 2019-08-15 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
| CA3091646A1 (en) | 2018-02-14 | 2019-08-22 | Abba Therapeutics Ag | Anti-human pd-l2 antibodies |
| WO2019165122A1 (en) | 2018-02-21 | 2019-08-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| RU2020128111A (ru) | 2018-02-21 | 2022-03-21 | Дженентек, Инк. | ВЕДЕНИЕ БЕЛКОВ СЛИЯНИЯ IL-22 Fc ДЛЯ ЛЕЧЕНИЯ |
| CA3092108A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| TWI841551B (zh) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 使用靶向4-1bb (cd137)之促效劑的組合療法 |
| MX2020009468A (es) | 2018-03-13 | 2020-10-22 | Hoffmann La Roche | Terapias de combinacion de agonistas de 4-1bb con anticuerpos anti-cd20. |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| US20200040103A1 (en) | 2018-03-14 | 2020-02-06 | Genentech, Inc. | Anti-klk5 antibodies and methods of use |
| TW202003562A (zh) | 2018-03-14 | 2020-01-16 | 中國大陸商北京軒義醫藥科技有限公司 | 抗密連蛋白18.2(cldn18.2)抗體 |
| TWI887899B (zh) | 2018-03-15 | 2025-06-21 | 日商中外製藥股份有限公司 | 對茲卡病毒具有交叉反應性的抗登革病毒抗體之用途 |
| PE20210290A1 (es) | 2018-03-21 | 2021-02-11 | Five Prime Therapeutics Inc | ANTICUERPOS DE UNION A VISTA A pH ACIDO |
| US11958903B2 (en) | 2018-03-30 | 2024-04-16 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies against LAG-3 and uses thereof |
| TW202011029A (zh) | 2018-04-04 | 2020-03-16 | 美商建南德克公司 | 偵測及定量fgf21之方法 |
| KR102764123B1 (ko) | 2018-04-05 | 2025-02-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Τ 세포 수용체 및 이를 발현하는 조작된 세포 |
| EP3773913A1 (en) | 2018-04-11 | 2021-02-17 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| BR112020016997A2 (pt) | 2018-04-13 | 2021-01-19 | F. Hoffmann-La Roche Ag | Moléculas de ligação e de ácido nucleico isolada, vetor, célula hospedeira, métodos para produzir a molécula de ligação, para tratar um indivíduo com câncer e para regular positivamente ou prolongar a atividade de células t, composição farmacêutica e uso da molécula de ligação |
| EP3560945A1 (en) | 2018-04-27 | 2019-10-30 | F. Hoffmann-La Roche AG | Methods for purification of polypeptides using polysorbates |
| WO2019228514A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and uses thereof for treating disease or condition |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| EP3805400A4 (en) | 2018-06-04 | 2022-06-29 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule showing changed half-life in cytoplasm |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| SG11202012342WA (en) | 2018-06-18 | 2021-01-28 | Eureka Therapeutics Inc | Constructs targeting prostate-specific membrane antigen (psma) and uses thereof |
| US12275797B2 (en) | 2018-06-22 | 2025-04-15 | Genmab Holding B.V. | Anti-CD37 antibodies and anti-CD20 antibodies, compositions and methods of use thereof |
| AU2019288728A1 (en) | 2018-06-23 | 2021-01-14 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| CN112424228B (zh) | 2018-07-04 | 2024-08-09 | 豪夫迈·罗氏有限公司 | 新型双特异性激动性4-1bb抗原结合分子 |
| CN113056483B (zh) | 2018-07-09 | 2025-08-01 | 戊瑞治疗有限公司 | 结合到ilt4的抗体 |
| EP3820475A4 (en) | 2018-07-09 | 2022-04-13 | Takeda Pharmaceutical Company Limited | Administration of sumo-activating enzyme inhibitor and anti-cd20 antibodies |
| WO2020014306A1 (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| EP3820902A2 (en) | 2018-07-11 | 2021-05-19 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
| TW202011991A (zh) | 2018-07-18 | 2020-04-01 | 美商建南德克公司 | 用pd-1軸結合拮抗劑、抗代謝劑及鉑劑治療肺癌之方法 |
| MX2021000745A (es) | 2018-07-20 | 2021-03-26 | Surface Oncology Inc | Composiciones anti-cd112r y metodos. |
| US12195533B2 (en) | 2018-07-24 | 2025-01-14 | Inhibrx Biosciences, Inc. | Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same |
| CN113286824A (zh) | 2018-08-03 | 2021-08-20 | 中外制药株式会社 | 包含两个彼此连接的抗原结合结构域的抗原结合分子 |
| US12172106B2 (en) | 2018-08-09 | 2024-12-24 | Regeneron Pharmaceuticals, Inc. | Methods for assessing binding affinity of an antibody variant to the neonatal Fc receptor |
| MX2021001431A (es) | 2018-08-10 | 2021-05-12 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno anti grupo de diferenciacion 137 (cd137) y su uso. |
| CN112584863B (zh) | 2018-08-17 | 2025-10-28 | Ab工作室有限公司 | 催化抗体和其使用方法 |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| CN112673022B (zh) | 2018-09-10 | 2024-07-09 | 南京传奇生物科技有限公司 | 针对cd33的单结构域抗体及其构建体 |
| CN112955747A (zh) | 2018-09-19 | 2021-06-11 | 豪夫迈·罗氏有限公司 | 膀胱癌的治疗和诊断方法 |
| ES2955032T3 (es) | 2018-09-21 | 2023-11-28 | Hoffmann La Roche | Métodos de diagnóstico para el cáncer de mama triple negativo |
| US20220002370A1 (en) | 2018-09-27 | 2022-01-06 | Xilio Development, Inc. | Masked cytokine polypeptides |
| EP3861026A1 (en) | 2018-10-01 | 2021-08-11 | F. Hoffmann-La Roche AG | Bispecific antigen binding molecules comprising anti-fap clone 212 |
| EP3861025A1 (en) | 2018-10-01 | 2021-08-11 | F. Hoffmann-La Roche AG | Bispecific antigen binding molecules with trivalent binding to cd40 |
| EP3632929A1 (en) | 2018-10-02 | 2020-04-08 | Ospedale San Raffaele S.r.l. | Antibodies and uses thereof |
| US20220010020A1 (en) | 2018-10-05 | 2022-01-13 | Five Prime Therapeutics, Inc. | Anti-FGFR2 Antibody Formulations |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3864049A1 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
| WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
| AU2019361983A1 (en) | 2018-10-18 | 2021-05-20 | Genentech, Inc. | Diagnostic and therapeutic methods for sarcomatoid kidney cancer |
| CA3118312A1 (en) * | 2018-10-29 | 2020-05-07 | Tigatx, Inc. | Compositions and methods comprising iga antibody constructs |
| US20210395390A1 (en) | 2018-10-31 | 2021-12-23 | Bayer Aktiengesellschaft | Reversal agents for neutralizing the therapeutic activity of anti-fxia antibodies |
| EP4640698A2 (en) | 2018-11-16 | 2025-10-29 | Memorial Sloan Kettering Cancer Center | Antibodies to mucin-16 and methods of use thereof |
| CA3120729A1 (en) | 2018-11-27 | 2020-06-04 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing granulocyte-macrophage colony stimulating factor receptor alpha and uses thereof |
| EP4198057A1 (en) | 2018-12-05 | 2023-06-21 | F. Hoffmann-La Roche AG | Diagnostic methods and compositions for cancer immunotherapy |
| WO2020117257A1 (en) | 2018-12-06 | 2020-06-11 | Genentech, Inc. | Combination therapy of diffuse large b-cell lymphoma comprising an anti-cd79b immunoconjugates, an alkylating agent and an anti-cd20 antibody |
| JP2022513198A (ja) | 2018-12-10 | 2022-02-07 | ジェネンテック, インコーポレイテッド | Fc含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド |
| WO2020132230A2 (en) | 2018-12-20 | 2020-06-25 | Genentech, Inc. | Modified antibody fcs and methods of use |
| WO2020132214A2 (en) | 2018-12-20 | 2020-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ebola virus glycoprotein-specific monoclonal antibodies and uses thereof |
| US11608376B2 (en) | 2018-12-21 | 2023-03-21 | Hoffmann-La Roche Inc. | Tumor-targeted agonistic CD28 antigen binding molecules |
| CN113286822A (zh) | 2018-12-21 | 2021-08-20 | 豪夫迈·罗氏有限公司 | 靶向肿瘤的超激动性cd28抗原结合分子 |
| KR20210142594A (ko) | 2018-12-26 | 2021-11-25 | 시티 오브 호프 | 활성화 가능한 차폐된 항-ctla4 결합 단백질 |
| CN113272327A (zh) | 2018-12-30 | 2021-08-17 | 豪夫迈·罗氏有限公司 | 抗兔cd19抗体及其使用方法 |
| JP2022518399A (ja) | 2019-01-14 | 2022-03-15 | ジェネンテック, インコーポレイテッド | Pd-1軸結合アンタゴニスト及びrnaワクチンを用いてがんを処置する方法 |
| EP3911675A1 (en) | 2019-01-17 | 2021-11-24 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc) |
| CN113795511B (zh) | 2019-01-23 | 2024-07-23 | 大有华夏生物医药集团有限公司 | 抗pd-l1双抗体及其用途 |
| WO2020153467A1 (ja) | 2019-01-24 | 2020-07-30 | 中外製薬株式会社 | 新規がん抗原及びそれらの抗原に対する抗体 |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| WO2020160050A1 (en) | 2019-01-29 | 2020-08-06 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1) |
| EP3918323A4 (en) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | ANTI-GAL3 ANTIBODIES AND USES THEREOF |
| CN119661722A (zh) | 2019-02-21 | 2025-03-21 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| JP2022521773A (ja) | 2019-02-27 | 2022-04-12 | ジェネンテック, インコーポレイテッド | 抗tigit抗体と抗cd20抗体又は抗cd38抗体とによる処置のための投薬 |
| EP3935385A1 (en) | 2019-03-08 | 2022-01-12 | F. Hoffmann-La Roche AG | Methods for detecting and quantifying membrane-associated proteins on extracellular vesicles |
| CR20210467A (es) | 2019-03-14 | 2021-10-07 | Genentech Inc | Tratamiento de cáncer con anticuerpos biespecíficos contra her2xcd3 en combinación con mab anti-her2 |
| WO2020208049A1 (en) | 2019-04-12 | 2020-10-15 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecules comprising lipocalin muteins |
| AU2020257748A1 (en) | 2019-04-19 | 2021-11-18 | Chugai Seiyaku Kabushiki Kaisha | Chimeric receptor recognizing modification site of antibody |
| BR112021020867A2 (pt) | 2019-04-19 | 2022-01-04 | Genentech Inc | Anticorpos, ácido nucleico, vetor, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, usos do anticorpo, método de tratamento de um indivíduo com câncer e método para reduzir a depuração |
| EP3962523A2 (en) | 2019-05-03 | 2022-03-09 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
| KR20220004744A (ko) | 2019-05-03 | 2022-01-11 | 제넨테크, 인크. | 항-pd-l1 항체를 이용하여 암을 치료하는 방법 |
| EP3968993A1 (en) | 2019-05-14 | 2022-03-23 | F. Hoffmann-La Roche AG | Methods of using anti-cd79b immunoconjugates to treat follicular lymphoma |
| US20230085439A1 (en) | 2019-05-21 | 2023-03-16 | University Of Georgia Research Foundation, Inc. | Antibodies that bind human metapneumovirus fusion protein and their use |
| MX2021014274A (es) | 2019-05-23 | 2022-01-06 | Ac Immune Sa | Moleculas de union anti-tdp-43 y usos de las mismas. |
| BR112021023735A2 (pt) * | 2019-06-05 | 2022-01-04 | Chugai Pharmaceutical Co Ltd | Molécula de ligação de sítio de clivagem de anti-corpo |
| BR112021026293A2 (pt) | 2019-06-26 | 2022-03-03 | Hoffmann La Roche | Moléculas de ligação, anticorpos humanizados, ácido nucleico isolado, célula hospedeira, métodos para produzir a molécula de ligação ao antígeno, para tratar um indivíduo e suprarregular ou prolongar a atividade de células t citotóxicas, composição farmacêutica e uso da molécula |
| JP7354306B2 (ja) | 2019-06-27 | 2023-10-02 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 新規icos抗体及びそれらを含む腫瘍標的化抗原結合分子 |
| JP2022539589A (ja) | 2019-07-02 | 2022-09-12 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ | EGFRvIIIと結合するモノクローナル抗体およびその使用 |
| US20220372138A1 (en) | 2019-07-05 | 2022-11-24 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
| AU2020311511B2 (en) | 2019-07-09 | 2024-08-29 | Beijing Solobio Genetechnology Co., Ltd. | Antibodies specifically recognizing Pseudomonas PcrV and uses thereof |
| EP3998083A4 (en) | 2019-07-12 | 2023-08-23 | Chugai Seiyaku Kabushiki Kaisha | Anti-mutation type fgfr3 antibody and use therefor |
| TWI832183B (zh) | 2019-08-06 | 2024-02-11 | 香港商新旭生技股份有限公司 | 結合至病理性tau種類之抗體及其用途 |
| MX2022002963A (es) | 2019-09-12 | 2022-04-06 | Genentech Inc | Composiciones y metodos para tratar nefritis lupica. |
| PE20220566A1 (es) | 2019-09-19 | 2022-04-13 | Bristol Myers Squibb Co | ANTICUERPOS DE UNION A VISTA A pH ACIDO |
| US20220348687A1 (en) | 2019-09-20 | 2022-11-03 | Genentech, Inc. | Dosing for anti-tryptase antibodies |
| CR20220127A (es) | 2019-09-27 | 2022-05-27 | Genentech Inc | Administración de dosis para tratamiento con anticuerpos antagonistas anti-tigit y anti-pd-l1 |
| CA3153880A1 (en) | 2019-10-18 | 2020-06-09 | Juana Elva HERNANDEZ MONTALVO | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma |
| US20220389103A1 (en) | 2019-11-06 | 2022-12-08 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers |
| EP4058593A4 (en) | 2019-11-12 | 2023-11-15 | Foundation Medicine, Inc. | METHOD FOR DETECTING A FUSION GENE CODING A NEOANTIGEN |
| KR20220100611A (ko) | 2019-11-15 | 2022-07-15 | 엔테라 에스.알.엘. | Tmem219 항체 및 이의 치료 용도 |
| EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
| CN114746442B (zh) | 2019-11-21 | 2025-08-26 | 恩瑟拉有限责任公司 | Igfbp3抗体及其治疗性用途 |
| US20230192869A1 (en) | 2019-12-06 | 2023-06-22 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods |
| JP2023504740A (ja) | 2019-12-06 | 2023-02-06 | ジュノー セラピューティクス インコーポレイテッド | Bcma標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法 |
| KR20220113790A (ko) | 2019-12-13 | 2022-08-16 | 제넨테크, 인크. | 항-ly6g6d 항체 및 사용 방법 |
| IL294226B2 (en) | 2019-12-27 | 2025-05-01 | Chugai Pharmaceutical Co Ltd | Anti-CTLA-4 antibodies and their use |
| CN113045655A (zh) | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| GB2609554B (en) | 2020-01-03 | 2025-08-20 | Marengo Therapeutics Inc | Anti-TCR antibody molecules and uses thereof |
| CA3162009A1 (en) | 2020-01-09 | 2021-07-15 | F. Hoffmann-La Roche Ag | New 4-1bbl trimer-containing antigen binding molecules |
| CN110818795B (zh) | 2020-01-10 | 2020-04-24 | 上海复宏汉霖生物技术股份有限公司 | 抗tigit抗体和使用方法 |
| WO2022050954A1 (en) | 2020-09-04 | 2022-03-10 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| WO2021194481A1 (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| IL294879A (en) | 2020-01-29 | 2022-09-01 | Inhibrx Inc | Cd28 single domain antibodies and multivalent and multispecific constructs thereof |
| CA3165319A1 (en) | 2020-01-31 | 2021-08-05 | Vincent K. Tuohy | Anti-mullerian hormone receptor 2 antibodies and methods of use |
| BR112022015077A2 (pt) | 2020-01-31 | 2022-10-04 | Genentech Inc | Métodos para induzir células t cd8+ específicas de neoepítopos em um indivíduo com um tumor e para induzir o tráfico de células t cd8+, vacinas de rna, vacina de rna para uso e antagonistas de ligação |
| TWI895351B (zh) | 2020-02-12 | 2025-09-01 | 日商中外製藥股份有限公司 | 用於癌症之治療的抗cd137抗原結合分子 |
| MX2022009947A (es) | 2020-02-14 | 2022-11-07 | Jounce Therapeutics Inc | Anticuerpos y proteinas de fusion que se unen a ccr8 y usos de estos. |
| US20230348568A1 (en) | 2020-02-20 | 2023-11-02 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Epstein-barr virus monoclonal antibodies and uses thereof |
| EP3868396A1 (en) | 2020-02-20 | 2021-08-25 | Enthera S.R.L. | Inhibitors and uses thereof |
| KR20220145859A (ko) | 2020-02-28 | 2022-10-31 | 상하이 헨리우스 바이오테크, 인크. | 항cd137 작제물, 다중 특이적 항체 및 그 용도 |
| CN115066440A (zh) | 2020-02-28 | 2022-09-16 | 上海复宏汉霖生物技术股份有限公司 | 抗cd137构建体及其用途 |
| EP4118114A1 (en) | 2020-03-13 | 2023-01-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| US11919948B2 (en) | 2020-03-19 | 2024-03-05 | Genentech, Inc. | Isoform-selective anti-TGFβ antibodies and methods of use |
| WO2021194865A1 (en) | 2020-03-23 | 2021-09-30 | Genentech, Inc. | Method for treating pneumonia, including covid-19 pneumonia, with an il6 antagonist |
| JP2023518812A (ja) | 2020-03-23 | 2023-05-08 | ジェネンテック, インコーポレイテッド | Covid19肺炎を治療するための、トシリズマブとレムデシビルとの組み合わせ |
| CN115867577A (zh) | 2020-03-23 | 2023-03-28 | 基因泰克公司 | 用于预测covid-19肺炎中对il-6拮抗剂反应的生物标志物 |
| PE20230414A1 (es) | 2020-03-24 | 2023-03-07 | Genentech Inc | Agentes de fijacion a tie2 y metodos de uso |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| WO2021202959A1 (en) | 2020-04-03 | 2021-10-07 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
| WO2021207662A1 (en) | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome |
| IL297541A (en) | 2020-04-24 | 2022-12-01 | Genentech Inc | Methods for using anti-cd79b immunoconjugates |
| CA3172880A1 (en) | 2020-04-27 | 2021-11-04 | Sotirios Tsimikas | Isoform-independent antibodies to lipoprotein(a) |
| EP4143345A1 (en) | 2020-04-28 | 2023-03-08 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
| IL297830A (en) | 2020-05-03 | 2023-01-01 | Levena Suzhou Biopharma Co Ltd | Antibody-drug conjugates (adcs) comprising an anti-trop-2 antibody, compositions comprising such adcs, as well as methods of making and using the same |
| JP2023525085A (ja) | 2020-05-13 | 2023-06-14 | アダジーン アーゲー | がんを治療するための組成物および方法 |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| WO2021238886A1 (en) | 2020-05-27 | 2021-12-02 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing nerve growth factor and uses thereof |
| TW202210515A (zh) | 2020-06-02 | 2022-03-16 | 美商當康生物科技有限公司 | 抗cd39之構築體及其用途 |
| CN116529260A (zh) | 2020-06-02 | 2023-08-01 | 当康生物技术有限责任公司 | 抗cd93构建体及其用途 |
| JP2023529206A (ja) | 2020-06-12 | 2023-07-07 | ジェネンテック, インコーポレイテッド | がん免疫療法のための方法及び組成物 |
| CA3181820A1 (en) | 2020-06-16 | 2021-12-23 | Genentech, Inc. | Methods and compositions for treating triple-negative breast cancer |
| WO2021257124A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| BR112022025856A2 (pt) | 2020-06-19 | 2023-01-10 | Hoffmann La Roche | Anticorpo que se liga a cd3 e cd19, polinucleotídeo isolado, célula hospedeira, método de produção de um anticorpo que se liga a cd3 e cd19, composição farmacêutica, uso do anticorpo, método para tratar uma doença em um indivíduo e invenção |
| PE20231361A1 (es) | 2020-06-23 | 2023-09-05 | Hoffmann La Roche | Moleculas agonistas de union al antigeno cd28 que se dirigen a her2 |
| EP4172203A1 (en) | 2020-06-25 | 2023-05-03 | F. Hoffmann-La Roche AG | Anti-cd3/anti-cd28 bispecific antigen binding molecules |
| EP4175668A1 (en) | 2020-07-06 | 2023-05-10 | iOmx Therapeutics AG | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
| JP2023532764A (ja) | 2020-07-07 | 2023-07-31 | エフ. ホフマン-ラ ロシュ アーゲー | 治療用タンパク質製剤の安定剤としての代替界面活性剤 |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| CN116783215A (zh) | 2020-07-29 | 2023-09-19 | 当康生物技术有限责任公司 | 抗cd93构建体及其用途 |
| WO2022031749A1 (en) | 2020-08-03 | 2022-02-10 | Genentech, Inc. | Diagnostic and therapeutic methods for lymphoma |
| WO2022029660A1 (en) | 2020-08-05 | 2022-02-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods |
| WO2022031876A1 (en) | 2020-08-07 | 2022-02-10 | Genentech, Inc. | Flt3 ligand fusion proteins and methods of use |
| EP4196162A1 (en) | 2020-08-14 | 2023-06-21 | AC Immune SA | Humanized anti-tdp-43 binding molecules and uses thereof |
| WO2022043517A2 (en) | 2020-08-27 | 2022-03-03 | Cureab Gmbh | Anti-golph2 antibodies for macrophage and dendritic cell differentiation |
| CN116249719A (zh) | 2020-09-15 | 2023-06-09 | 拜耳公司 | 新的抗a2ap抗体及其用途 |
| CN116685351A (zh) | 2020-09-17 | 2023-09-01 | 基因泰克公司 | Empacta的结果:一项用于评估托珠单抗在患有covid-19肺炎的住院患者中的功效和安全性的随机、双盲、安慰剂对照、多中心研究 |
| AU2021348613A1 (en) | 2020-09-28 | 2023-06-08 | Angitia Incorporated Limited | Anti-sclerostin constructs and uses thereof |
| JP2023544407A (ja) | 2020-10-05 | 2023-10-23 | ジェネンテック, インコーポレイテッド | 抗FcRH5/抗CD3二重特異性抗体による処置のための投与 |
| JP2023545566A (ja) | 2020-10-20 | 2023-10-30 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Pd-1軸結合アンタゴニストとlrrk2阻害剤との併用療法 |
| WO2022084400A1 (en) | 2020-10-20 | 2022-04-28 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments specifically binding to gremlin-1 and uses thereof |
| WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
| AU2021374803A1 (en) | 2020-11-03 | 2023-06-22 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Target-cell restricted, costimulatory, bispecific and bivalent anti-cd28 antibodies |
| WO2022098638A2 (en) | 2020-11-04 | 2022-05-12 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| US20220153842A1 (en) | 2020-11-04 | 2022-05-19 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
| MX2023005130A (es) | 2020-11-04 | 2023-05-25 | Genentech Inc | Dosis subcutanea de anticuerpos biespecificos anti-cd20/anti-cd3. |
| JP2023549316A (ja) | 2020-11-16 | 2023-11-24 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Fapを標的としたcd40アゴニストとの併用療法 |
| TW202235431A (zh) | 2020-11-25 | 2022-09-16 | 美商艾希利歐發展股份有限公司 | 腫瘤特異性可裂解連接子 |
| TW202237638A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 烏苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法 |
| TW202237639A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 鳥苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法 |
| WO2022132904A1 (en) | 2020-12-17 | 2022-06-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies targeting sars-cov-2 |
| JP2024503826A (ja) | 2021-01-06 | 2024-01-29 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Pd1-lag3二重特異性抗体及びcd20 t細胞二重特異性抗体を用いる併用療法 |
| WO2022162587A1 (en) | 2021-01-27 | 2022-08-04 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| WO2022162203A1 (en) | 2021-01-28 | 2022-08-04 | Vaccinvent Gmbh | Method and means for modulating b-cell mediated immune responses |
| AU2022212599A1 (en) | 2021-01-28 | 2023-08-17 | Universität Ulm | Method and means for modulating b-cell mediated immune responses |
| CN117120084A (zh) | 2021-01-28 | 2023-11-24 | 维肯芬特有限责任公司 | 用于调节b细胞介导的免疫应答的方法和手段 |
| AU2022221297A1 (en) | 2021-02-09 | 2023-08-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies targeting the spike protein of coronaviruses |
| CA3210753A1 (en) | 2021-02-09 | 2022-08-18 | University Of Georgia Research Foundation, Inc. | Human monoclonal antibodies against pneumococcal antigens |
| US20240226295A9 (en) | 2021-02-15 | 2024-07-11 | Takeda Pharmaceutical Company Limited | Cell therapy compositions and methods for modulating tgf-b signaling |
| WO2022180172A1 (en) | 2021-02-26 | 2022-09-01 | Bayer Aktiengesellschaft | Inhibitors of il-11 or il-11ra for use in the treatment of abnormal uterine bleeding |
| EP4301467A1 (en) | 2021-03-01 | 2024-01-10 | Xilio Development, Inc. | Combination of ctla4 and pd1/pdl1 antibodies for treating cancer |
| CA3209364A1 (en) | 2021-03-01 | 2022-09-09 | Jennifer O'neil | Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer |
| EP4301418A1 (en) | 2021-03-03 | 2024-01-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates comprising an anti-bcma antibody |
| CN117715933A (zh) | 2021-03-05 | 2024-03-15 | 当康生物技术有限责任公司 | 抗vista的构建体及其用途 |
| TW202300521A (zh) | 2021-03-15 | 2023-01-01 | 美商建南德克公司 | 治療狼瘡性腎炎的組成物及方法 |
| WO2022197877A1 (en) | 2021-03-19 | 2022-09-22 | Genentech, Inc. | Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents |
| JP2024511424A (ja) | 2021-03-25 | 2024-03-13 | ダイナミキュア バイオテクノロジー エルエルシー | 抗igfbp7構築物およびその使用 |
| IL307233A (en) | 2021-03-30 | 2023-11-01 | Bayer Ag | Anti-SEMA3A antibodies and uses thereof |
| AR125344A1 (es) | 2021-04-15 | 2023-07-05 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-c1s |
| TW202244059A (zh) | 2021-04-30 | 2022-11-16 | 瑞士商赫孚孟拉羅股份公司 | 用抗cd20/抗cd3雙特異性抗體進行治療之給藥 |
| EP4330282A1 (en) | 2021-04-30 | 2024-03-06 | F. Hoffmann-La Roche AG | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| CA3218170A1 (en) | 2021-05-12 | 2022-11-17 | Jamie Harue HIRATA | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma |
| KR20240007171A (ko) | 2021-05-14 | 2024-01-16 | 제넨테크, 인크. | 모수네투주맙 및 폴라투주맙 베도틴을 이용한 cd20 양성 증식성 장애의 치료 방법 |
| TW202306993A (zh) | 2021-05-14 | 2023-02-16 | 美商建南德克公司 | Trem2之促效劑 |
| WO2022243261A1 (en) | 2021-05-19 | 2022-11-24 | F. Hoffmann-La Roche Ag | Agonistic cd40 antigen binding molecules targeting cea |
| AR126009A1 (es) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam |
| TW202306994A (zh) | 2021-06-04 | 2023-02-16 | 日商中外製藥股份有限公司 | 抗ddr2抗體及其用途 |
| CA3216220A1 (en) | 2021-06-09 | 2022-12-15 | F. Hoffmann-La Roche Ag | Combination of a particular braf inhibitor (paradox breaker) and a pd-1 axis binding antagonist for use in the treatment of cancer |
| MX2023014658A (es) | 2021-06-11 | 2024-01-12 | Genentech Inc | Metodo para tratar la enfermedad pulmonar obstructiva cronica con un antagonista de st2. |
| WO2022263638A1 (en) | 2021-06-17 | 2022-12-22 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| US12227574B2 (en) | 2021-06-17 | 2025-02-18 | Amberstone Biosciences, Inc. | Anti-CD3 constructs and uses thereof |
| CA3220353A1 (en) | 2021-06-25 | 2022-12-29 | Chugai Seiyaku Kabushiki Kaisha | Use of anti-ctla-4 antibody |
| CR20240026A (es) | 2021-06-25 | 2024-03-14 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-ctla-4 |
| US20250011448A1 (en) | 2021-07-08 | 2025-01-09 | Staidson Biopharma Inc. | Antibodies specifically recognizing tnfr2 and uses thereof |
| JP2024525769A (ja) | 2021-07-14 | 2024-07-12 | 舒泰神(北京)生物製薬股フン有限公司 | Cd40を特異的に認識する抗体およびその使用 |
| JP2024526880A (ja) | 2021-07-22 | 2024-07-19 | ジェネンテック, インコーポレイテッド | 脳標的化組成物及びその使用方法 |
| US20240336697A1 (en) | 2021-08-07 | 2024-10-10 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma |
| WO2023019239A1 (en) | 2021-08-13 | 2023-02-16 | Genentech, Inc. | Dosing for anti-tryptase antibodies |
| JP2024534067A (ja) | 2021-08-19 | 2024-09-18 | エフ. ホフマン-ラ ロシュ アーゲー | 多価抗バリアントfc領域抗体および使用方法 |
| IL310382A (en) | 2021-08-27 | 2024-03-01 | Genentech Inc | Methods for treating tau pathologies |
| MX2024002611A (es) | 2021-08-30 | 2024-05-29 | Lassen Therapeutics 1 Inc | Anticuerpos anti-il-11ra. |
| TW202325727A (zh) | 2021-08-30 | 2023-07-01 | 美商建南德克公司 | 抗聚泛素多特異性抗體 |
| WO2023044272A1 (en) | 2021-09-17 | 2023-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies |
| EP4405398A4 (en) | 2021-09-21 | 2025-10-29 | Qilu Puget Sound Biotherapeutics Corp | FC HETERODIMERS ALLOWING THE MANUFACTURE OF FUSION PROTEINS AND BI-SPECIFIC ANTIBODIES |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法 |
| KR20240082388A (ko) | 2021-10-08 | 2024-06-10 | 추가이 세이야쿠 가부시키가이샤 | 프리필드 시린지 제제의 조제 방법 |
| AU2022379952A1 (en) | 2021-11-05 | 2024-05-16 | Mab Biotec, Inc. | Monoclonal antibodies against carcinoembryonic antigens, and their uses |
| EP4430072A1 (en) | 2021-11-10 | 2024-09-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| MX2024005680A (es) | 2021-11-16 | 2024-05-30 | Genentech Inc | Metodos y composiciones para tratar lupus eritematoso sistemico (sle) con mosunetuzumab. |
| TW202334202A (zh) | 2021-11-16 | 2023-09-01 | 瑞士商Ac免疫有限公司 | 用於治療和診斷的新分子 |
| EP4445911A4 (en) | 2021-12-06 | 2025-10-22 | Beijing Solobio Genetechnology Co Ltd | BISPECIFIC ANTIBODY THAT BINDS SPECIFICALLY TO KLEBSIELLA PNEUMONIAE O1 AND O2 ANTIGENS AND COMPOSITION |
| WO2023109901A1 (en) | 2021-12-17 | 2023-06-22 | Shanghai Henlius Biotech, Inc. | Anti-ox40 antibodies and methods of use |
| KR20240116755A (ko) | 2021-12-17 | 2024-07-30 | 상하이 헨리우스 바이오테크, 인크. | 항-ox40 항체, 다중 특이적 항체 및 이의 사용 방법 |
| CR20240246A (es) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| UY40097A (es) | 2022-01-07 | 2023-07-14 | Johnson & Johnson Entpr Innovation Inc | Materiales y métodos de proteínas de unión a il-1b |
| JP2025506172A (ja) | 2022-02-10 | 2025-03-07 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | コロナウイルスを広く標的とするヒトモノクローナル抗体 |
| EP4479426A1 (en) | 2022-02-16 | 2024-12-25 | AC Immune SA | Humanized anti-tdp-43 binding molecules and uses thereof |
| JP2025508739A (ja) | 2022-02-18 | 2025-04-10 | ラクテン・メディカル,インコーポレイテッド | 抗プログラム細胞死リガンド1(pd-l1)抗体分子、それをコードするポリヌクレオチド、および使用方法 |
| WO2023173026A1 (en) | 2022-03-10 | 2023-09-14 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| EP4496631A1 (en) | 2022-03-23 | 2025-01-29 | F. Hoffmann-La Roche AG | Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy |
| WO2023179740A1 (en) | 2022-03-25 | 2023-09-28 | Shanghai Henlius Biotech , Inc. | Anti-msln antibodies and methods of use |
| EP4499227A1 (en) | 2022-03-26 | 2025-02-05 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Bispecific antibodies to hiv-1 env and their use |
| US20250197483A1 (en) | 2022-03-28 | 2025-06-19 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Neutralizing antibodies to hiv-1 env and their use |
| CN119095880A (zh) | 2022-03-28 | 2024-12-06 | 豪夫迈·罗氏有限公司 | 干扰素γ变体以及包含这些变体的抗原结合分子 |
| WO2023191816A1 (en) | 2022-04-01 | 2023-10-05 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| JP2025513799A (ja) | 2022-04-08 | 2025-04-30 | エイシー イミューン ソシエテ アノニム | 抗tdp-43結合分子 |
| EP4508087A1 (en) | 2022-04-13 | 2025-02-19 | Genentech, Inc. | Pharmaceutical compositions of therapeutic proteins and methods of use |
| TW202404637A (zh) | 2022-04-13 | 2024-02-01 | 瑞士商赫孚孟拉羅股份公司 | 抗cd20/抗cd3雙特異性抗體之醫藥組成物及使用方法 |
| CA3243581A1 (en) | 2022-04-20 | 2023-10-26 | Kantonsspital St. Gallen | ANTIBODIES OR ANTIGEN-BINDING FRAGMENTS THAT BIND PANSPECIFICALLY TO GREMLIN-1 AND GREMLIN-2 AND RELATED USES |
| PE20242350A1 (es) | 2022-05-03 | 2024-12-16 | Genentech Inc | Anticuerpos anti-ly6e, inmunoconjugados y usos de estos |
| WO2023217068A1 (zh) | 2022-05-09 | 2023-11-16 | 舒泰神(北京)生物制药股份有限公司 | 特异性识别gdf15的抗体及其应用 |
| CA3251472A1 (en) | 2022-05-11 | 2023-11-16 | Genentech, Inc. | DOSAGE FOR TREATMENT WITH ANTI-FCRH5/ANTI-CD3 BISPECIFIC ANTIBODIES |
| WO2023235699A1 (en) | 2022-05-31 | 2023-12-07 | Jounce Therapeutics, Inc. | Antibodies to lilrb4 and uses thereof |
| US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11807689B1 (en) * | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| KR20250022049A (ko) | 2022-06-07 | 2025-02-14 | 제넨테크, 인크. | 항-pd-l1 길항제 및 항-tigit 길항제 항체를 포함하는, 폐암 치료의 효율을 결정하는 방법 |
| US20250382354A1 (en) | 2022-06-08 | 2025-12-18 | Institute For Research In Biomedicine (Irb) | Cross-specific antibodies, uses and methods for discovery thereof |
| CN119585308A (zh) | 2022-07-13 | 2025-03-07 | 基因泰克公司 | 针对用抗fcrh5/抗cd3双特异性抗体进行的治疗的给药 |
| TW202417503A (zh) | 2022-07-19 | 2024-05-01 | 美商舒泰神(加州)生物科技有限公司 | 特異性識別b和t淋巴細胞衰減器(btla)的抗體及其應用 |
| EP4558524A1 (en) | 2022-07-19 | 2025-05-28 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| EP4558529A1 (en) | 2022-07-22 | 2025-05-28 | Bristol-Myers Squibb Company | Antibodies binding to human pad4 and uses thereof |
| CR20250056A (es) | 2022-07-22 | 2025-03-19 | Genentech Inc | Moléculas de unión al antígeno anti-steap1 y sus usos. |
| EP4565329A1 (en) | 2022-08-01 | 2025-06-11 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Monoclonal antibodies that bind to the underside of influenza viral neuraminidase |
| EP4565330A1 (en) | 2022-08-05 | 2025-06-11 | Janssen Biotech, Inc. | Transferrin receptor binding proteins for treating brain tumors |
| EP4565331A1 (en) | 2022-08-05 | 2025-06-11 | Janssen Biotech, Inc. | Cd98 binding constructs for treating brain tumors |
| CA3265385A1 (en) | 2022-08-22 | 2024-02-29 | Abdera Therapeutics Inc. | DLL3 BINDING MOLECULES AND THEIR USES |
| AU2023329484A1 (en) | 2022-08-26 | 2025-02-20 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for delta-like ligand 3 (dll3) |
| CN120153254A (zh) | 2022-09-01 | 2025-06-13 | 基因泰克公司 | 膀胱癌的治疗和诊断方法 |
| WO2024054929A1 (en) | 2022-09-07 | 2024-03-14 | Dynamicure Biotechnology Llc | Anti-vista constructs and uses thereof |
| WO2024054822A1 (en) | 2022-09-07 | 2024-03-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Engineered sars-cov-2 antibodies with increased neutralization breadth |
| AU2023345467A1 (en) | 2022-09-21 | 2025-05-08 | Sanofi Biotechnology | Humanized anti-il-1r3 antibody and methods of use |
| WO2024064826A1 (en) | 2022-09-22 | 2024-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
| CN119998321A (zh) | 2022-09-27 | 2025-05-13 | 舒泰神(北京)生物制药股份有限公司 | 特异性识别light的抗体及其应用 |
| WO2024068996A1 (en) | 2022-09-30 | 2024-04-04 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| JP2025535386A (ja) | 2022-10-20 | 2025-10-24 | 北京三▲諾▼佳邑生物技▲術▼有限▲責▼任公司 | TRAILまたはFasLに特異的に結合する抗体の組み合わせおよび二重特異性抗体 |
| WO2024091991A1 (en) | 2022-10-25 | 2024-05-02 | Genentech, Inc. | Therapeutic and diagnostic methods for multiple myeloma |
| WO2024094741A1 (en) | 2022-11-03 | 2024-05-10 | F. Hoffmann-La Roche Ag | Combination therapy with anti-cd19/anti-cd28 bispecific antibody |
| JP2025537137A (ja) | 2022-11-04 | 2025-11-14 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ccr8抗体、化学療法及び免疫療法の組み合わせを使用する抗がん療法 |
| AU2023375342A1 (en) | 2022-11-08 | 2025-04-24 | F. Hoffmann-La Roche Ag | Compositions and methods of treating childhood onset idiopathic nephrotic syndrome |
| WO2024100200A1 (en) | 2022-11-09 | 2024-05-16 | Cis Pharma Ag | Anti-l1-cam antibodies and their uses for diagnostic and therapeutic applications |
| KR20250106304A (ko) | 2022-11-17 | 2025-07-09 | 사노피 | Ceacam5 항체-약물 접합체 및 이의 사용 방법 |
| CN120265651A (zh) | 2022-11-25 | 2025-07-04 | 中外制药株式会社 | 用于生产蛋白质的方法 |
| WO2024137381A1 (en) | 2022-12-19 | 2024-06-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies for treating sars-cov-2 infection |
| EP4491230A1 (en) | 2023-07-14 | 2025-01-15 | iOmx Therapeutics AG | Cross-specific antigen binding proteins (abp) targeting leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2, combinations and uses thereof |
| EP4637924A2 (en) | 2022-12-23 | 2025-10-29 | iOmx Therapeutics AG | Cross-specific antigen binding proteins (abp) targeting leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2, combinations and uses thereof |
| EP4646441A1 (en) | 2023-01-06 | 2025-11-12 | Lassen Therapeutics, Inc. | Anti-il-11r alpha antibodies for treating thyroid eye disease |
| KR20250133728A (ko) | 2023-01-06 | 2025-09-08 | 라센 테라퓨틱스, 인코포레이티드 | 항-il-18bp 항체 |
| TW202430560A (zh) | 2023-01-06 | 2024-08-01 | 美商拉森醫療公司 | 抗il-18bp抗體 |
| WO2024184494A1 (en) | 2023-03-08 | 2024-09-12 | Ac Immune Sa | Anti-tdp-43 binding molecules and uses thereof |
| EP4428158A1 (en) | 2023-03-10 | 2024-09-11 | Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. | Lung cancer targeting human antibodies and therapeutic uses thereof |
| EP4428159A1 (en) | 2023-03-10 | 2024-09-11 | Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. | Melanoma targeting human antibodies and therapeutic uses thereof |
| CN120835901A (zh) | 2023-03-13 | 2025-10-24 | 豪夫迈·罗氏有限公司 | 采用pd1-lag3双特异性抗体和hla-g t细胞双特异性抗体的组合疗法 |
| WO2024211234A1 (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| WO2024211235A1 (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| WO2024211236A2 (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| WO2024212827A1 (en) | 2023-04-12 | 2024-10-17 | Shanghai Kangabio Co., Limited | Multifunctional molecules comprising masked interleukin 12 and methods of use |
| WO2024220546A2 (en) | 2023-04-17 | 2024-10-24 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
| AU2024270495A1 (en) | 2023-05-05 | 2025-10-09 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| AU2024268933A1 (en) | 2023-05-10 | 2025-11-20 | Chugai Seiyaku Kabushiki Kaisha | Methods and compositions for treating cancer |
| WO2024243355A1 (en) | 2023-05-24 | 2024-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that target the rh5 complex of blood-stage plasmodium falciparum |
| TW202504918A (zh) | 2023-06-01 | 2025-02-01 | 瑞士商赫孚孟拉羅股份公司 | 靶向bcma及cd28的雙特異性抗體 |
| AR132805A1 (es) | 2023-06-01 | 2025-07-30 | Hoffmann La Roche | Moléculas de unión al antígeno inmunoestimuladoras que se unen específicamente a bcma |
| WO2024254455A1 (en) | 2023-06-08 | 2024-12-12 | Genentech, Inc. | Macrophage signatures for diagnostic and therapeutic methods for lymphoma |
| WO2024261013A1 (en) | 2023-06-21 | 2024-12-26 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
| WO2024263845A1 (en) | 2023-06-22 | 2024-12-26 | Genentech, Inc. | Treatment of multiple myeloma |
| WO2025014896A1 (en) | 2023-07-07 | 2025-01-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Humanized 40h3 antibody |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2025024233A1 (en) | 2023-07-21 | 2025-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bispecific antibodies that broadly target coronaviruses |
| WO2025021790A2 (en) | 2023-07-24 | 2025-01-30 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
| WO2025034806A1 (en) | 2023-08-08 | 2025-02-13 | Wisconsin Alumni Research Foundation | Single-domain antibodies and variants thereof against fibroblast activation protein |
| WO2025032070A1 (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Anti-a-beta protein antibodies, methods and uses thereof |
| WO2025032069A1 (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof |
| WO2025032071A1 (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof |
| WO2025038492A1 (en) | 2023-08-11 | 2025-02-20 | Abalytics Oncology, Inc. | Anti-ctla-4 antibodies and related binding molecules and methods and uses thereof |
| WO2025045251A2 (en) | 2023-09-03 | 2025-03-06 | Kira Pharmaceuticals (Us) Llc | Multispecific constructs comprising anti-factor d moiety |
| WO2025064539A1 (en) | 2023-09-19 | 2025-03-27 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Herv-e antibodies and methods of their use |
| EP4537907A1 (en) | 2023-10-10 | 2025-04-16 | Enthera S.r.l. | Cd248 inhibitors and uses thereof |
| WO2025085489A1 (en) | 2023-10-17 | 2025-04-24 | Bristol-Myers Squibb Company | Gspt1-degrading compounds, anti-cd33 antibodies and antibody-drug conjugates and uses thereof |
| TW202517674A (zh) | 2023-10-19 | 2025-05-01 | 德商拜耳廠股份有限公司 | 抗gpc3抗體及其放射性結合物 |
| WO2025106474A1 (en) | 2023-11-14 | 2025-05-22 | Genentech, Inc. | Therapeutic and diagnostic methods for treating cancer with anti-fcrh5/anti-cd3 bispecific antibodies |
| WO2025106427A1 (en) | 2023-11-14 | 2025-05-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing and protective monoclonal antibodies against respiratory syncytial virus (rsv) |
| WO2025111402A1 (en) | 2023-11-21 | 2025-05-30 | Board Of Regents Of The University Of Nebraska | Anti-amyloid beta antibodies and related compositions and methods thereof |
| WO2025117384A1 (en) | 2023-12-01 | 2025-06-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly neutralizing influenza hemagglutinin stem-directed antibodies |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
| WO2025137284A2 (en) | 2023-12-21 | 2025-06-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly neutralizing antibodies against sars-cov-2 and sars-cov variants |
| WO2025174974A1 (en) | 2024-02-14 | 2025-08-21 | Bristol-Myers Squibb Company | Anti-cd33 antibodies and uses thereof |
| WO2025179281A1 (en) | 2024-02-23 | 2025-08-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Treatment of cardiovascular disease with antxr1 antibodies |
| WO2025184416A1 (en) | 2024-02-27 | 2025-09-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single-domain antibodies and bispecific antibodies against hiv-1 and their use |
| WO2025184421A1 (en) | 2024-02-28 | 2025-09-04 | Juno Therapeutics, Inc. | Chimeric antigen receptors and antibodies specific for delta-like ligand 3 (dll3) and related methods |
| WO2025199352A2 (en) | 2024-03-20 | 2025-09-25 | Juno Therapeutics, Inc. | Antibodies specific for solute carrier family 34 member 2 (slc34a2) |
| US20250295801A1 (en) | 2024-03-21 | 2025-09-25 | Seagen Inc. | Cd25 antibodies, antibody drug conjugates, and uses thereof |
| WO2025215124A2 (en) | 2024-04-12 | 2025-10-16 | F. Hoffmann-La Roche Ag | Combination treatment of glofitamab and chemotherapy |
| WO2025218725A1 (zh) * | 2024-04-18 | 2025-10-23 | 徕特康(苏州)生物制药有限公司 | 靶向cd20和cd89的髓细胞衔接子抗体及其用途 |
| WO2025226808A1 (en) | 2024-04-24 | 2025-10-30 | Genentech, Inc. | Compositions and methods of treating lupus nephritis |
| WO2025238187A1 (en) | 2024-05-15 | 2025-11-20 | Cis Biopharma Ag | Immunoconjugates targeting l1-cam |
| WO2025240670A2 (en) | 2024-05-15 | 2025-11-20 | Abalytics Oncology, Inc. | Anti-pd-1 antibodies and related binding molecules and methods and uses thereof |
| WO2025242909A1 (en) | 2024-05-24 | 2025-11-27 | Paul Scherrer Institut | CD30-targeting antibody-radioligand conjugates and their therapeutic use |
| WO2025250969A1 (en) | 2024-05-31 | 2025-12-04 | Vertex Pharmaceuticals Incorporated | Anti-cd74 antibodies, conjugates and uses thereof |
Family Cites Families (174)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7097A (en) | 1850-02-19 | Elevating- and lowering carriage-tops | ||
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6893625B1 (en) * | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5262296A (en) | 1988-03-30 | 1993-11-16 | Toray Industries, Inc. | Freeze-dried composition containing enzyme-labeled anti-human interferon-β antibody and enzyme immunoassay kit containing the composition |
| US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| EP0556285A4 (en) | 1990-11-05 | 1993-10-27 | Bristol-Myers Squibb Company | Synergistic therapy with combinations of anti-tumor antibodies and biologically active agents |
| US7744877B2 (en) * | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
| PT752248E (pt) * | 1992-11-13 | 2001-01-31 | Idec Pharma Corp | Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US20030180290A1 (en) * | 1995-06-07 | 2003-09-25 | Idec Pharmaceuticals Corporation | Anti-CD80 antibody having ADCC activity for ADCC mediated killing of B cell lymphoma cells alone or in combination with other therapies |
| DK1516628T3 (da) | 1995-07-27 | 2013-09-08 | Genentech Inc | Stabil, isotonisk lyofiliseret proteinformulering |
| US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
| JP2000516594A (ja) | 1996-07-26 | 2000-12-12 | スミスクライン・ビーチャム・コーポレイション | 免疫細胞介在全身性疾患の改良された治療法 |
| UA76934C2 (en) * | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
| ES2335365T3 (es) | 1996-11-27 | 2010-03-25 | Genentech, Inc. | Purificacion por afinidad de polipeptido en una matriz de proteina a. |
| US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6991790B1 (en) | 1997-06-13 | 2006-01-31 | Genentech, Inc. | Antibody formulation |
| EP0999853B1 (en) | 1997-06-13 | 2003-01-02 | Genentech, Inc. | Stabilized antibody formulation |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US20040191256A1 (en) * | 1997-06-24 | 2004-09-30 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
| JP2002506353A (ja) | 1997-06-24 | 2002-02-26 | ジェネンテック・インコーポレーテッド | ガラクトシル化糖タンパク質の方法及び組成物 |
| WO1999022764A1 (en) | 1997-10-31 | 1999-05-14 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| ATE512225T1 (de) * | 1998-04-03 | 2011-06-15 | Chugai Pharmaceutical Co Ltd | Humanisierter antikörper gegen den menschlichen gewebefaktor (tf) und verfahren für die konstruktion eines solchen humanisierten antikörpers. |
| PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| KR100960211B1 (ko) | 1998-05-06 | 2010-05-27 | 제넨테크, 인크. | 이온 교환 크로마토그래피에 의한 단백질 정제 방법 |
| DE69939939D1 (de) | 1998-08-11 | 2009-01-02 | Idec Pharma Corp | Kombinationstherapien gegen b-zell-lymphome beinhaltend die verabreichung von anti-cd20-antikörpern |
| WO2000010007A2 (en) | 1998-08-17 | 2000-02-24 | California Institute Of Technology | Devices and methods for analysis of non-ionic solutes |
| US6224866B1 (en) | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
| ES2351149T3 (es) * | 1998-11-09 | 2011-02-01 | Biogen Idec Inc. | Anticuerpo quimérico dirigido contra cd20, el rituxan, para uso en el tratamiento de la leucemia linfocítica crónica. |
| TR200101302T2 (tr) * | 1998-11-09 | 2001-10-22 | Idec Pharmaceuticals Corporation | BMT yada PBSC transplantı alan hastalarda in vitro ya da in vivo temizleyici madde olarak kimerik anti-CD20 antikorunun kullanımı. |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
| WO2000061739A1 (fr) | 1999-04-09 | 2000-10-19 | Kyowa Hakko Kogyo Co., Ltd. | Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle |
| IL146005A0 (en) | 1999-05-07 | 2002-07-25 | Genentech Inc | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| KR20020020730A (ko) | 1999-06-09 | 2002-03-15 | 오트리브 데이비스 더블유 | B-세포를 표적하는 항체를 이용한 자가면역질환의 면역치료 |
| KR20020027490A (ko) | 1999-07-12 | 2002-04-13 | 제넨테크, 인크. | Cd20에 결합하는 길항제를 사용한 외래 항원에 대한면역 반응 차단 방법 |
| US6451284B1 (en) | 1999-08-11 | 2002-09-17 | Idec Pharmaceuticals Corporation | Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy |
| JP2003513012A (ja) | 1999-08-11 | 2003-04-08 | アイデック ファーマスーティカルズ コーポレイション | 抗cd20抗体による骨髄病変を伴う非ホジキンリンパ腫を有する患者の治療 |
| US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
| CN1169952C (zh) | 1999-10-10 | 2004-10-06 | 中国医学科学院中国协和医科大学血液学研究所血液病医院 | 抗cd20单克隆抗体的重链和轻链可变区基因及其应用 |
| US20020028178A1 (en) * | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| KR20020072277A (ko) * | 1999-11-08 | 2002-09-14 | 아이덱 파마슈티칼즈 코포레이션 | 항-cd20 항체 및/또는 화학요법 및 방사선요법과결합하여 항-cd40l 항체를 이용한 b세포 악성종양의치료방법 |
| US20020006404A1 (en) * | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| US20040038339A1 (en) | 2000-03-24 | 2004-02-26 | Peter Kufer | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| CN1981868A (zh) * | 2000-03-31 | 2007-06-20 | 拜奥根Idec公司 | 抗细胞因子抗体或拮抗剂与抗-cd20在b细胞淋巴瘤治疗中的联合应用 |
| CA2405632A1 (en) | 2000-04-25 | 2001-11-01 | Idec Pharmaceutical Corporation | Intrathecal administration of rituximab for treatment of central nervous system lymphomas |
| JP2004512262A (ja) * | 2000-06-20 | 2004-04-22 | アイデック ファーマスーティカルズ コーポレイション | 非放射性抗cd20抗体/放射標識抗cd22抗体の組合せ |
| CA2415100A1 (en) | 2000-07-12 | 2002-01-17 | Idec Pharmaceutical Corporation | Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications |
| NZ523912A (en) * | 2000-07-31 | 2005-03-24 | Biolex Inc | Expression of biologically active polypeptides in duckweed |
| DE10043452A1 (de) | 2000-09-04 | 2002-03-14 | Basf Ag | Formkörper mit einer tonmineralischen Beschichtung |
| KR20040023565A (ko) * | 2000-09-18 | 2004-03-18 | 아이덱 파마슈티칼즈 코포레이션 | B 세포 고갈/면역조절 항체 조합을 이용한 자가면역질환의 치료를 위한 조합 요법 |
| WO2002034790A1 (en) | 2000-10-20 | 2002-05-02 | Idec Pharmaceuticals Corporation | Variant igg3 rituxan r and therapeutic use thereof |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030103971A1 (en) * | 2001-11-09 | 2003-06-05 | Kandasamy Hariharan | Immunoregulatory antibodies and uses thereof |
| US20020159996A1 (en) * | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| US20030211107A1 (en) * | 2002-01-31 | 2003-11-13 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| JP4463475B2 (ja) * | 2001-01-31 | 2010-05-19 | バイオジェン アイデック インコーポレイテッド | 腫瘍疾患の治療における免疫調節性抗体の使用 |
| US20020147312A1 (en) | 2001-02-02 | 2002-10-10 | O'keefe Theresa | Hybrid antibodies and uses thereof |
| US20030077826A1 (en) | 2001-02-02 | 2003-04-24 | Lena Edelman | Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC) |
| AU2002307037B2 (en) * | 2001-04-02 | 2008-08-07 | Biogen Idec Inc. | Recombinant antibodies coexpressed with GnTIII |
| EP2359849A1 (en) | 2001-04-02 | 2011-08-24 | Genentech, Inc. | Combination therapy |
| WO2003061694A1 (en) | 2001-05-10 | 2003-07-31 | Seattle Genetics, Inc. | Immunosuppression of the humoral immune response by anti-cd20 antibodies |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| JP2005538706A (ja) * | 2001-07-12 | 2005-12-22 | ジェファーソン フーテ, | スーパーヒト化抗体 |
| CA2838062C (en) * | 2001-08-03 | 2015-12-22 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| US7192586B2 (en) * | 2001-09-20 | 2007-03-20 | Cornell Research Foundation, Inc. | Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate specific membrane antigen |
| NZ532526A (en) * | 2001-10-25 | 2007-01-26 | Genentech Inc | Compositions comprising a glycoprotein having a Fc region |
| US20040093621A1 (en) * | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| MXPA04006357A (es) | 2001-12-27 | 2005-03-31 | Glycofi Inc | Metodos para disenar estructuras de carbohidrato del tipo de mamifero. |
| KR101033196B1 (ko) * | 2002-02-14 | 2011-05-09 | 이뮤노메딕스, 인코오포레이티드 | 항-cd20 항체 및 그 융합 단백질 및 이들의 이용방법 |
| US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US20030180292A1 (en) * | 2002-03-14 | 2003-09-25 | Idec Pharmaceuticals | Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy |
| CN1665934B (zh) | 2002-03-19 | 2010-05-26 | 国际植物研究所 | GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达 |
| CN1283662C (zh) | 2002-03-21 | 2006-11-08 | 伊莱利利公司 | 拮抗性抗hFAS配基人类抗体及其片段 |
| WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| US20030190689A1 (en) * | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
| AU2003236019A1 (en) * | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kirin Co., Ltd. | Drug containing antibody composition appropriate for patient suffering from Fc Gamma RIIIa polymorphism |
| WO2003084569A1 (en) * | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Drug containing antibody composition |
| WO2004000102A2 (en) * | 2002-06-19 | 2003-12-31 | Abgenix, Inc. | Method for predicting response to epidermal growth factor receptor-directed therapy |
| JP4459810B2 (ja) | 2002-08-14 | 2010-04-28 | マクロジェニクス,インコーポレーテッド | FcγRIIB特異的抗体とその利用法 |
| ATE472604T1 (de) | 2002-09-12 | 2010-07-15 | Greenovation Biotech Gmbh | Verfahren zur herstellung von proteinen |
| PT1558648E (pt) | 2002-10-17 | 2012-04-23 | Genmab As | Anticorpos monoclonais humanos contra cd20 |
| EP1578947A4 (en) * | 2002-12-02 | 2006-12-06 | Abgenix Inc | ANTIBODIES TAKEN AGAINST PHOSPHOLIPASE A2 AND USES THEREOF |
| KR20050084317A (ko) | 2002-12-16 | 2005-08-26 | 제넨테크, 인크. | 인간 cd20 및(또는) cd16을 발현하는 트랜스제닉마우스 |
| AR042485A1 (es) * | 2002-12-16 | 2005-06-22 | Genentech Inc | Anticuerpo humanizado que se une al cd20 humano |
| AU2003294912B2 (en) | 2002-12-20 | 2009-06-04 | Greenovation Biotech Gmbh | Production of heterologous glycosylated proteins in bryophyte cells |
| JP2006524039A (ja) * | 2003-01-09 | 2006-10-26 | マクロジェニクス,インコーポレーテッド | 変異型Fc領域を含む抗体の同定および作製ならびにその利用法 |
| US7960512B2 (en) * | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| PL222220B1 (pl) | 2003-01-22 | 2016-07-29 | Glycart Biotechnology Ag | Komórka gospodarza i sposób wytwarzania polipeptydu w komórce gospodarza |
| US7575893B2 (en) * | 2003-01-23 | 2009-08-18 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| CA2518980A1 (en) * | 2003-03-14 | 2004-09-30 | Pharmacia Corporation | Antibodies to igf-i receptor for the treatment of cancers |
| MXPA05010778A (es) * | 2003-04-09 | 2005-12-12 | Genentech Inc | Terapia para enfermedad autoinmune en un paciente con una respuesta inadecuada a un inhibidor tnf-alfa. |
| AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| NZ543712A (en) | 2003-06-05 | 2008-06-30 | Genentech Inc | Combination therapy for B cell disorders |
| US20050163775A1 (en) * | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
| WO2005017529A1 (en) | 2003-07-29 | 2005-02-24 | Genentech, Inc. | Assay for human anti cd20 antibodies and uses therefor |
| US20050042664A1 (en) * | 2003-08-22 | 2005-02-24 | Medimmune, Inc. | Humanization of antibodies |
| JP2007504138A (ja) * | 2003-08-29 | 2007-03-01 | ジェネンテック・インコーポレーテッド | 眼疾患の治療法 |
| TR201809892T4 (tr) | 2003-11-05 | 2018-07-23 | Roche Glycart Ag | Fc reseptörüne bağlanma afinitesi ve artırılmış efektör fonksiyonu bulunan antijen bağlayan moleküller. |
| EP1696955A2 (en) * | 2003-12-19 | 2006-09-06 | Genentech, Inc. | Detection of cd20 in therapy of autoimmune diseases |
| AU2004303848A1 (en) | 2003-12-19 | 2005-07-07 | Genentech, Inc. | Detection of CD20 in transplant rejection |
| WO2005062955A2 (en) | 2003-12-23 | 2005-07-14 | Rinat Neuroscience Corp. | Agonist anti-trkc antibodies and methods using same |
| WO2005079479A2 (en) | 2004-02-17 | 2005-09-01 | Absalus, Inc. | Super-humanized antibodies against respiratory syncytial virus |
| AU2005244751A1 (en) | 2004-04-16 | 2005-12-01 | Genentech, Inc. | Method for augmenting B cell depletion |
| BRPI0509419A (pt) * | 2004-04-16 | 2007-09-04 | Genentech Inc | método de ensaio imunossorvente ligado por enzimas, anticorpos, hibridoma e kit de imunoensaio |
| EP1742660A2 (en) * | 2004-04-16 | 2007-01-17 | Genentech, Inc. | Treatment of disorders |
| CN1980697A (zh) | 2004-05-05 | 2007-06-13 | 健泰科生物技术公司 | 通过使用抗cd20抗体预防自身免疫病 |
| WO2005114218A2 (en) | 2004-05-15 | 2005-12-01 | Genentech, Inc. | Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule |
| AR049292A1 (es) | 2004-06-04 | 2006-07-12 | Genentech Inc | Metodo para tratar lupus con un anticuerpo cd20 |
| AU2005249566B2 (en) | 2004-06-04 | 2010-11-11 | Genentech, Inc. | Method for treating multiple sclerosis |
| US7501121B2 (en) * | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| EP1781378A2 (en) | 2004-07-22 | 2007-05-09 | Genentech, Inc. | Method of treating sjögren's syndrome |
| KR20070057839A (ko) | 2004-08-19 | 2007-06-07 | 제넨테크, 인크. | 변경된 이펙터 기능을 갖는 폴리펩티드 변이체 |
| AU2005282397A1 (en) | 2004-09-08 | 2006-03-16 | Genentech, Inc. | Methods of using death receptor ligands and CD20 antibodies |
| BRPI0515615A (pt) | 2004-09-08 | 2008-07-29 | Genentech Inc | métodos para tratar células cancerosas e doença imune relacionada |
| MX2007002883A (es) * | 2004-09-13 | 2007-06-15 | Macrogenics Inc | Anticuerpos humanizados contra el virus de nilo occidental y usos terapeuticos y profilacticos del mismo. |
| ZA200702335B (en) * | 2004-10-05 | 2009-05-27 | Genentech Inc | Method for treating vasculitis |
| ES2434732T3 (es) | 2004-12-15 | 2013-12-17 | Janssen Alzheimer Immunotherapy | Anticuerpos para beta-amiloide humanizados para su uso en mejorar la cognición |
| RU2007126970A (ru) * | 2004-12-17 | 2009-01-27 | Джинентех, Инк. (US) | Антиагиогенная терапия аутоиммунного заболевания у пациентов, предшествующее лечение которых не дало результата |
| JP2008525041A (ja) * | 2004-12-22 | 2008-07-17 | ジェネンテック・インコーポレーテッド | 可溶性多膜貫通型タンパク質の産生方法 |
| US20060188495A1 (en) | 2005-01-13 | 2006-08-24 | Genentech, Inc. | Treatment method |
| DOP2006000029A (es) | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
| TW200714289A (en) | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
| AR053579A1 (es) | 2005-04-15 | 2007-05-09 | Genentech Inc | Tratamiento de la enfermedad inflamatoria intestinal (eii) |
| KR20070122497A (ko) | 2005-04-22 | 2007-12-31 | 제넨테크, 인크. | Cd20 항체로 치매 또는 알츠하이머병을 치료하는 방법 |
| WO2006125140A2 (en) | 2005-05-18 | 2006-11-23 | Biogen Idec Inc. | Methods for treating fibrotic conditions |
| CN101223448B (zh) | 2005-05-20 | 2012-01-18 | 健泰科生物技术公司 | 来自自身免疫病受试者的生物学样品的预处理 |
| AU2006255085A1 (en) | 2005-06-03 | 2006-12-14 | Genentech, Inc. | Method of producing antibodies with modified fucosylation level |
| NO345919B1 (no) * | 2005-08-26 | 2021-10-18 | Roche Glycart Ag | Modifiserte antigen-bindende molekyler med endret celle-signaliseringsaktivitet |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| ES2618543T3 (es) | 2005-11-23 | 2017-06-21 | Genentech, Inc. | Métodos y composiciones relacionados con ensayos de linfocitos B |
| US20070136826A1 (en) | 2005-12-02 | 2007-06-14 | Biogen Idec Inc. | Anti-mouse CD20 antibodies and uses thereof |
| US7708944B1 (en) | 2006-06-13 | 2010-05-04 | Research Foundation Of State University Of New York | Ultra-sensitive, portable capillary sensor |
| CN101711286A (zh) | 2007-04-02 | 2010-05-19 | 健泰科生物技术公司 | 预示类风湿性关节炎对b细胞拮抗剂的响应的生物学标志物 |
| US20090004189A1 (en) | 2007-06-18 | 2009-01-01 | Genentech, Inc. | Biological markers predictive of rheumatoid arthritis response to b-cell antagonists |
| HUE046992T2 (hu) | 2007-07-09 | 2020-04-28 | Genentech Inc | Diszulfidkötés redukciójának megelõzése polipeptidek rekombináns elõállítása során |
| KR100898362B1 (ko) | 2007-07-10 | 2009-05-18 | 주식회사 그리폰 | 다목적 신발 |
| US20110243931A1 (en) | 2007-09-02 | 2011-10-06 | Thomas Friess | Combination therapy with type i and type ii anti-cd20 antibodies |
| GB0718684D0 (en) | 2007-09-24 | 2007-10-31 | Roche Products Ltd | Treatment method |
| US20090214561A1 (en) | 2007-09-24 | 2009-08-27 | David Robert Close | Treatment method |
| US20090098118A1 (en) | 2007-10-15 | 2009-04-16 | Thomas Friess | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
| US20090110688A1 (en) | 2007-10-24 | 2009-04-30 | Georg Fertig | Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor |
| US20090148435A1 (en) | 2007-10-30 | 2009-06-11 | Genentech, Inc. | Antibody purification by cation exchange chromatography |
| AU2008342956A1 (en) | 2007-12-21 | 2009-07-09 | Genentech, Inc. | Therapy of rituximab-refractory rheumatoid arthritis patients |
| US20090162351A1 (en) | 2007-12-21 | 2009-06-25 | Depuy Spine, Inc. | Transdiscal administration of inhibitors of p38 MAP kinase |
| AU2008340429C1 (en) | 2007-12-21 | 2016-09-08 | F. Hoffmann-La Roche Ag | Antibody formulation |
| CA2708951A1 (en) | 2007-12-21 | 2009-07-09 | Genetech, Inc. | Crystallization of anti-cd20 antibodies |
| HUE028828T2 (en) | 2008-03-25 | 2017-01-30 | Roche Glycart Ag | Use of type II anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity (ADDC) in combination with cyclophosphamide, vincristine, and doxorubicin for the treatment of non-hodgkin's lymphomas |
| WO2009134738A1 (en) | 2008-04-29 | 2009-11-05 | Genentech, Inc. | Responses to immunizations in rheumatoid arthritis patients treated with a cd20 antibody |
| US8021850B2 (en) | 2008-07-14 | 2011-09-20 | Ribo Guo | Universal tandem solid-phases based immunoassay |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | Genentech Inc | 治療進展型多發性硬化症之方法 |
| KR20140133588A (ko) | 2008-11-17 | 2014-11-19 | 제넨테크, 인크. | 생리적 조건하에 거대분자의 응집을 감소시키는 방법 및 제제 |
| BRPI0916072A2 (pt) | 2008-11-17 | 2015-11-10 | Genentech Inc | "uso de uma formulação, formulação farmacêutica, usos de um anticorpo 2h7 humanizado, método, método para aumentar a biodisponibilidade de um anticorpo e método de diálise in vitro" |
| US20100247484A1 (en) | 2009-03-31 | 2010-09-30 | Heinrich Barchet | Combination therapy of an afucosylated antibody and one or more of the cytokines gm csf, m csf and/or il3 |
| TWI409079B (zh) | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法 |
| WO2011018225A1 (en) | 2009-08-14 | 2011-02-17 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with fludarabine and/or mitoxantrone |
| MX2012002766A (es) | 2009-09-03 | 2012-04-02 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| WO2011131749A1 (en) | 2010-04-23 | 2011-10-27 | Glaxo Group Limited | New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases |
| RU2013106216A (ru) | 2010-08-03 | 2014-09-10 | Ф. Хоффманн-Ля Рош Аг | Биомаркеры хронической лимфоцитарной лейкемии |
| AR082693A1 (es) | 2010-08-17 | 2012-12-26 | Roche Glycart Ag | Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf |
| WO2012118750A2 (en) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Biological markers and methods for predicting response to b-cell antagonists |
| US8592156B2 (en) | 2011-08-08 | 2013-11-26 | Roche Molecular Systems, Inc. | Predicting response to anti-CD20 therapy in DLBCL patients |
| US20140172120A1 (en) | 2012-09-06 | 2014-06-19 | Freedom Innovations, Llc | Method and system for a prosthetic device with multiple levels of functionality enabled through multiple control systems |
| HK1212240A1 (en) | 2012-09-07 | 2016-06-10 | 吉宁特有限公司 | Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor |
-
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/11/2004, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |