JP4095895B2 - Ｒｎａ干渉を媒介する短鎖ｒｎａ分子 - Google Patents

Ｒｎａ干渉を媒介する短鎖ｒｎａ分子 Download PDF

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JP4095895B2
JP4095895B2 JP2002546670A JP2002546670A JP4095895B2 JP 4095895 B2 JP4095895 B2 JP 4095895B2 JP 2002546670 A JP2002546670 A JP 2002546670A JP 2002546670 A JP2002546670 A JP 2002546670A JP 4095895 B2 JP4095895 B2 JP 4095895B2
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rna
dsrna
gene
sirna
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JP2004526422A5 (https=
JP2004526422A (ja
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トゥシュル，トーマス
エルバッシャー，セイダ
レンデッケル，ウィンフリード
ウィルム，マティアス
ルールマン，ラインハルト
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マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー．ヴェー．
ユーロペーイシェ ラボラトリウム フュール モレキュラーバイオロジー（イーエムビーエル）
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Priority claimed from PCT/US2001/010188 external-priority patent/WO2001075164A2/en
Application filed by マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー．ヴェー．, ユーロペーイシェ ラボラトリウム フュール モレキュラーバイオロジー（イーエムビーエル） filed Critical マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー．ヴェー．
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JP2002546670A 2000-12-01 2001-11-29 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子 Expired - Lifetime JP4095895B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00126325 2000-12-01
US27966101P 2001-03-30 2001-03-30
PCT/US2001/010188 WO2001075164A2 (en) 2000-03-30 2001-03-30 Rna sequence-specific mediators of rna interference
PCT/EP2001/013968 WO2002044321A2 (en) 2000-12-01 2001-11-29 Rna interference mediating small rna molecules

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JP2004526422A JP2004526422A (ja) 2004-09-02
JP2004526422A5 JP2004526422A5 (https=) 2006-06-08
JP4095895B2 true JP4095895B2 (ja) 2008-06-04

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JP2002546670A Expired - Lifetime JP4095895B2 (ja) 2000-12-01 2001-11-29 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
JP2006317758A Expired - Lifetime JP4494392B2 (ja) 2000-12-01 2006-11-24 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
JP2009210276A Expired - Lifetime JP6189576B2 (ja) 2000-12-01 2009-09-11 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
JP2010046471A Expired - Lifetime JP5749892B2 (ja) 2000-12-01 2010-03-03 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
JP2014251819A Expired - Lifetime JP6325974B2 (ja) 2000-12-01 2014-12-12 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子

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JP2006317758A Expired - Lifetime JP4494392B2 (ja) 2000-12-01 2006-11-24 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
JP2009210276A Expired - Lifetime JP6189576B2 (ja) 2000-12-01 2009-09-11 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
JP2010046471A Expired - Lifetime JP5749892B2 (ja) 2000-12-01 2010-03-03 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
JP2014251819A Expired - Lifetime JP6325974B2 (ja) 2000-12-01 2014-12-12 Ｒｎａ干渉を媒介する短鎖ｒｎａ分子

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US (25) US20040259247A1 (https=)
EP (3) EP2348133B1 (https=)
JP (5) JP4095895B2 (https=)
KR (2) KR100909681B1 (https=)
CN (1) CN100523215C (https=)
AT (1) ATE373724T2 (https=)
AU (3) AU2002235744B8 (https=)
BR (1) BRPI0115814B8 (https=)
CA (1) CA2429814C (https=)
CY (1) CY1119062T1 (https=)
CZ (2) CZ302719B6 (https=)
DE (1) DE60130583T3 (https=)
DK (2) DK1407044T4 (https=)
ES (2) ES2215494T5 (https=)
HU (1) HU230458B1 (https=)
IL (3) IL155991A0 (https=)
LT (1) LTPA2021005I1 (https=)
MX (1) MXPA03004836A (https=)
NO (2) NO333713B1 (https=)
NZ (1) NZ525888A (https=)
PL (1) PL218876B1 (https=)
PT (1) PT1407044E (https=)
RU (2) RU2322500C2 (https=)
SI (1) SI1407044T2 (https=)
TR (1) TR200401292T3 (https=)
WO (1) WO2002044321A2 (https=)
ZA (1) ZA200303929B (https=)

Cited By (20)

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US8084600B2 (en) 2006-05-04 2011-12-27 Novartis Ag Short interfering ribonucleic acid (siRNA) with improved pharmacological properties
US8097716B2 (en) 2003-08-28 2012-01-17 Novartis Ag Interfering RNA duplex having blunt-ends and 3′-modifications
US8664189B2 (en) 2008-09-22 2014-03-04 Rxi Pharmaceuticals Corporation RNA interference in skin indications
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
US9074211B2 (en) 2008-11-19 2015-07-07 Rxi Pharmaceuticals Corporation Inhibition of MAP4K4 through RNAI
US9080171B2 (en) 2010-03-24 2015-07-14 RXi Parmaceuticals Corporation Reduced size self-delivering RNAi compounds
US9095504B2 (en) 2010-03-24 2015-08-04 Rxi Pharmaceuticals Corporation RNA interference in ocular indications
US9200276B2 (en) 2009-06-01 2015-12-01 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent RNA interference, compositions and methods of use thereof
US9340786B2 (en) 2010-03-24 2016-05-17 Rxi Pharmaceuticals Corporation RNA interference in dermal and fibrotic indications
US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
US10131904B2 (en) 2008-02-11 2018-11-20 Rxi Pharmaceuticals Corporation Modified RNAi polynucleotides and uses thereof
US10731157B2 (en) 2015-08-24 2020-08-04 Halo-Bio Rnai Therapeutics, Inc. Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
US10808247B2 (en) 2015-07-06 2020-10-20 Phio Pharmaceuticals Corp. Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
US10900039B2 (en) 2014-09-05 2021-01-26 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
US10934550B2 (en) 2013-12-02 2021-03-02 Phio Pharmaceuticals Corp. Immunotherapy of cancer
US11001845B2 (en) 2015-07-06 2021-05-11 Phio Pharmaceuticals Corp. Nucleic acid molecules targeting superoxide dismutase 1 (SOD1)
US11021707B2 (en) 2015-10-19 2021-06-01 Phio Pharmaceuticals Corp. Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
US11279934B2 (en) 2014-04-28 2022-03-22 Phio Pharmaceuticals Corp. Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
US12544344B2 (en) 2017-04-19 2026-02-10 Phio Pharmaceuticals Corp. Topical delivery of nucleic acid compounds

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US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
US5639647A (en) * 1994-03-29 1997-06-17 Ribozyme Pharmaceuticals, Inc. 2'-deoxy-2'alkylnucleotide containing nucleic acid
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20040219569A1 (en) * 1999-07-06 2004-11-04 Fruma Yehiely Gene identification method
US20110003879A1 (en) * 2005-03-11 2011-01-06 Vincent Mark D Antisense oligonucleotides targeted to the coding region of thymidylate synthase and uses thereof
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
EP1071753A2 (en) * 1998-04-20 2001-01-31 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
CA2361201A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US7601494B2 (en) 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
US6656698B1 (en) * 1999-06-30 2003-12-02 Millennium Pharmaceuticals, Inc. 12832, a novel human kinase-like molecule and uses thereof
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
US8128922B2 (en) * 1999-10-20 2012-03-06 Johns Hopkins University Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
GB9925459D0 (en) 1999-10-27 1999-12-29 Plant Bioscience Ltd Gene silencing
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