|
EP0642589A4
(en)
*
|
1992-05-11 |
1997-05-21 |
Ribozyme Pharm Inc |
METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
|
|
US20030206887A1
(en)
*
|
1992-05-14 |
2003-11-06 |
David Morrissey |
RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
|
|
US5639647A
(en)
*
|
1994-03-29 |
1997-06-17 |
Ribozyme Pharmaceuticals, Inc. |
2'-deoxy-2'alkylnucleotide containing nucleic acid
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US20040219569A1
(en)
*
|
1999-07-06 |
2004-11-04 |
Fruma Yehiely |
Gene identification method
|
|
US20110003879A1
(en)
*
|
2005-03-11 |
2011-01-06 |
Vincent Mark D |
Antisense oligonucleotides targeted to the coding region of thymidylate synthase and uses thereof
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
|
CN101818145A
(zh)
|
1998-03-20 |
2010-09-01 |
联邦科学和工业研究组织 |
控制基因表达
|
|
EP1071753A2
(en)
*
|
1998-04-20 |
2001-01-31 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
CA2361201A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
US7601494B2
(en)
|
1999-03-17 |
2009-10-13 |
The University Of North Carolina At Chapel Hill |
Method of screening candidate compounds for susceptibility to biliary excretion
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
US6656698B1
(en)
*
|
1999-06-30 |
2003-12-02 |
Millennium Pharmaceuticals, Inc. |
12832, a novel human kinase-like molecule and uses thereof
|
|
US6423885B1
(en)
|
1999-08-13 |
2002-07-23 |
Commonwealth Scientific And Industrial Research Organization (Csiro) |
Methods for obtaining modified phenotypes in plant cells
|
|
US8128922B2
(en)
*
|
1999-10-20 |
2012-03-06 |
Johns Hopkins University |
Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
|
|
GB9925459D0
(en)
|
1999-10-27 |
1999-12-29 |
Plant Bioscience Ltd |
Gene silencing
|
|
DE10100586C1
(de)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
|
DE10160151A1
(de)
*
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
US7829693B2
(en)
*
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
US7179796B2
(en)
|
2000-01-18 |
2007-02-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20050032733A1
(en)
*
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
|
US8273866B2
(en)
*
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
US20080039414A1
(en)
*
|
2002-02-20 |
2008-02-14 |
Sima Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US8202979B2
(en)
*
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US20030084471A1
(en)
*
|
2000-03-16 |
2003-05-01 |
David Beach |
Methods and compositions for RNA interference
|
|
EP1272630A2
(en)
|
2000-03-16 |
2003-01-08 |
Genetica, Inc. |
Methods and compositions for rna interference
|
|
US8202846B2
(en)
|
2000-03-16 |
2012-06-19 |
Cold Spring Harbor Laboratory |
Methods and compositions for RNA interference
|
|
ES2336887T5
(es)
|
2000-03-30 |
2019-03-06 |
Whitehead Inst Biomedical Res |
Mediadores de interferencia por ARN específicos de secuencias de ARN
|
|
EP2796553B1
(en)
*
|
2000-03-30 |
2019-06-19 |
Whitehead Institute for Biomedical Research |
RNA sequence-specific mediators of RNA interference
|
|
US20080242627A1
(en)
*
|
2000-08-02 |
2008-10-02 |
University Of Southern California |
Novel rna interference methods using dna-rna duplex constructs
|
|
US7662791B2
(en)
|
2000-08-02 |
2010-02-16 |
University Of Southern California |
Gene silencing using mRNA-cDNA hybrids
|
|
JP5087201B2
(ja)
*
|
2000-08-03 |
2012-12-05 |
ジョンズ・ホプキンス・ユニバーシティ |
抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン
|
|
US20030190635A1
(en)
*
|
2002-02-20 |
2003-10-09 |
Mcswiggen James A. |
RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
|
|
US20080032942A1
(en)
|
2000-08-30 |
2008-02-07 |
Mcswiggen James |
RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
|
|
US20020165192A1
(en)
|
2000-09-19 |
2002-11-07 |
Kerr William G. |
Control of NK cell function and survival by modulation of ship activity
|
|
US7691821B2
(en)
|
2001-09-19 |
2010-04-06 |
University Of South Florida |
Inhibition of SHIP to enhance stem cell harvest and transplantation
|
|
WO2009042910A2
(en)
*
|
2007-09-26 |
2009-04-02 |
University Of South Florida |
Ship inhibition to direct hematopoietic stem cells and induce extramedullary hematopoiesis
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
CA2429814C
(en)
*
|
2000-12-01 |
2014-02-18 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
|
CA2369944A1
(en)
*
|
2001-01-31 |
2002-07-31 |
Nucleonics Inc. |
Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
|
|
EP1386004A4
(en)
*
|
2001-04-05 |
2005-02-16 |
Ribozyme Pharm Inc |
MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
|
|
US20060211642A1
(en)
*
|
2001-05-18 |
2006-09-21 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
|
US20050164967A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
|
|
US20050159379A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc |
RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA)
|
|
US20050233996A1
(en)
*
|
2002-02-20 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
|
|
AU2004266311B2
(en)
*
|
2001-05-18 |
2009-07-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20050222066A1
(en)
*
|
2001-05-18 |
2005-10-06 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20070093437A1
(en)
*
|
2001-05-18 |
2007-04-26 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina)
|
|
US20050054596A1
(en)
*
|
2001-11-30 |
2005-03-10 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20050159382A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
|
|
US7517864B2
(en)
|
2001-05-18 |
2009-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20050176025A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
|
|
US20080161256A1
(en)
*
|
2001-05-18 |
2008-07-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
|
US20050159380A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA)
|
|
US20050048529A1
(en)
*
|
2002-02-20 |
2005-03-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
|
|
US20050176663A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sima Therapeutics, Inc. |
RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA)
|
|
US20050196767A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)
|
|
US20050267058A1
(en)
*
|
2001-05-18 |
2005-12-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA)
|
|
WO2005014811A2
(en)
*
|
2003-08-08 |
2005-02-17 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF XIAP GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20050191618A1
(en)
*
|
2001-05-18 |
2005-09-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
|
|
US20030175950A1
(en)
*
|
2001-05-29 |
2003-09-18 |
Mcswiggen James A. |
RNA interference mediated inhibition of HIV gene expression using short interfering RNA
|
|
US20050176024A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA)
|
|
US20080188430A1
(en)
*
|
2001-05-18 |
2008-08-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
|
US20050196765A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
|
|
US20050137155A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA)
|
|
US20070042983A1
(en)
*
|
2001-05-18 |
2007-02-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
|
US20050176666A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA)
|
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20050233997A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
|
US20050287128A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20050233344A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
|
|
US20050209180A1
(en)
*
|
2001-05-18 |
2005-09-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
|
US20050153914A1
(en)
*
|
2001-05-18 |
2005-07-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA)
|
|
US20050182007A1
(en)
*
|
2001-05-18 |
2005-08-18 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
|
US20050288242A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA)
|
|
US20090299045A1
(en)
*
|
2001-05-18 |
2009-12-03 |
Sirna Therapeutics, Inc. |
RNA Interference Mediated Inhibition Of Interleukin and Interleukin Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
|
US20040198682A1
(en)
*
|
2001-11-30 |
2004-10-07 |
Mcswiggen James |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA)
|
|
US20070270579A1
(en)
*
|
2001-05-18 |
2007-11-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
|
US20050124566A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
|
|
US20040019001A1
(en)
*
|
2002-02-20 |
2004-01-29 |
Mcswiggen James A. |
RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
|
|
US7109165B2
(en)
*
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
US20050014172A1
(en)
|
2002-02-20 |
2005-01-20 |
Ivan Richards |
RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA)
|
|
US9994853B2
(en)
|
2001-05-18 |
2018-06-12 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
|
US20050136436A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of G72 and D-amino acid oxidase (DAAO) gene expression using short interfering nucleic acid (siNA)
|
|
US20050261219A1
(en)
*
|
2001-05-18 |
2005-11-24 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20050143333A1
(en)
*
|
2001-05-18 |
2005-06-30 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
|
US20050124569A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
|
|
US20050196781A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of STAT3 gene expression using short interfering nucleic acid (siNA)
|
|
US20050187174A1
(en)
*
|
2001-05-18 |
2005-08-25 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
|
|
US20050176664A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA)
|
|
US20050239731A1
(en)
*
|
2001-05-18 |
2005-10-27 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)
|
|
US20040219671A1
(en)
*
|
2002-02-20 |
2004-11-04 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of parkinson disease using short interfering nucleic acid (siNA)
|
|
US20050256068A1
(en)
*
|
2001-05-18 |
2005-11-17 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
|
|
US20050203040A1
(en)
*
|
2001-05-18 |
2005-09-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
|
|
US20050119212A1
(en)
*
|
2001-05-18 |
2005-06-02 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA)
|
|
US20050159381A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA)
|
|
WO2002097114A2
(en)
*
|
2001-05-29 |
2002-12-05 |
Sirna Therapeutics, Inc. |
Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
|
|
US20050158735A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA)
|
|
US20050164224A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
|
|
US20050282188A1
(en)
*
|
2001-05-18 |
2005-12-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
|
US20050164968A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA)
|
|
US20060148743A1
(en)
*
|
2001-05-18 |
2006-07-06 |
Vasant Jadhav |
RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA)
|
|
US20050079610A1
(en)
*
|
2001-05-18 |
2005-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
|
|
US20060142225A1
(en)
*
|
2001-05-18 |
2006-06-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)
|
|
US20050159378A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
|
|
US8008472B2
(en)
|
2001-05-29 |
2011-08-30 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
|
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
EP2221376B1
(en)
|
2001-06-21 |
2012-11-21 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
IL159756A0
(en)
|
2001-07-12 |
2004-06-20 |
Univ Massachusetts |
IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
|
|
DE10133858A1
(de)
*
|
2001-07-12 |
2003-02-06 |
Aventis Pharma Gmbh |
Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
|
|
US10590418B2
(en)
|
2001-07-23 |
2020-03-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for RNAi mediated inhibition of gene expression in mammals
|
|
DK2280070T3
(en)
*
|
2001-07-23 |
2015-08-24 |
Univ Leland Stanford Junior |
Methods and compositions for use in RNAi-mediated inhibition of gene expression in mammals
|
|
US20090247606A1
(en)
*
|
2001-08-28 |
2009-10-01 |
Sirna Therapeutics, Inc. |
RNA Interference Mediated Inhibition of Adenosine A1 Receptor (ADORA1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
|
US20030198627A1
(en)
*
|
2001-09-01 |
2003-10-23 |
Gert-Jan Arts |
siRNA knockout assay method and constructs
|
|
US7745418B2
(en)
|
2001-10-12 |
2010-06-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting viral replication
|
|
DE10163098B4
(de)
|
2001-10-12 |
2005-06-02 |
Alnylam Europe Ag |
Verfahren zur Hemmung der Replikation von Viren
|
|
US20050119202A1
(en)
*
|
2001-10-26 |
2005-06-02 |
Roland Kreutzer |
Medicament to treat a fibrotic disease
|
|
WO2003035083A1
(de)
*
|
2001-10-26 |
2003-05-01 |
Ribopharma Ag |
Medikament zur behandlung einer fibrotischen erkrankung durch rna interferenz
|
|
WO2003035870A1
(de)
*
|
2001-10-26 |
2003-05-01 |
Ribopharma Ag |
Medikament zur behandlung eines pankreaskarzinoms
|
|
DE10230996A1
(de)
*
|
2001-10-26 |
2003-07-17 |
Ribopharma Ag |
Medikament zur Behandlung eines Pankreaskarzinoms
|
|
US20040063654A1
(en)
*
|
2001-11-02 |
2004-04-01 |
Davis Mark E. |
Methods and compositions for therapeutic use of RNA interference
|
|
AU2002348163A1
(en)
*
|
2001-11-02 |
2003-05-19 |
Intradigm Corporation |
Therapeutic methods for nucleic acid delivery vehicles
|
|
US20030157030A1
(en)
*
|
2001-11-02 |
2003-08-21 |
Insert Therapeutics, Inc. |
Methods and compositions for therapeutic use of rna interference
|
|
EP1445312B1
(en)
*
|
2001-11-21 |
2012-12-26 |
Astellas Pharma Inc. |
Method of inhibiting gene expression
|
|
US20040138163A1
(en)
*
|
2002-05-29 |
2004-07-15 |
Mcswiggen James |
RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20050075304A1
(en)
*
|
2001-11-30 |
2005-04-07 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20070203333A1
(en)
*
|
2001-11-30 |
2007-08-30 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US7294504B1
(en)
|
2001-12-27 |
2007-11-13 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Methods and compositions for DNA mediated gene silencing
|
|
WO2003062421A1
(en)
*
|
2002-01-17 |
2003-07-31 |
The University Of British Columbia |
Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same
|
|
DE10202419A1
(de)
|
2002-01-22 |
2003-08-07 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens
|
|
GB0201477D0
(en)
*
|
2002-01-23 |
2002-03-13 |
Novartis Forschungsstiftung |
Methods of obtaining isoform specific expression in mammalian cells
|
|
EP1572902B1
(en)
*
|
2002-02-01 |
2014-06-11 |
Life Technologies Corporation |
HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
|
|
ATE556714T1
(de)
|
2002-02-01 |
2012-05-15 |
Life Technologies Corp |
Doppelsträngige oligonukleotide
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
US20050096289A1
(en)
*
|
2002-02-07 |
2005-05-05 |
Hans Prydz |
Methods and compositions for modulating tissue factor
|
|
IL163547A0
(en)
*
|
2002-02-12 |
2005-12-18 |
Quark Biotech Inc |
Use of the axl receptor for diagnosis and treatment of renal disease
|
|
EP1474512A2
(en)
*
|
2002-02-13 |
2004-11-10 |
Axordia Limited |
Method to modify differentiation of pluripotential stem cells
|
|
US7820632B2
(en)
|
2002-02-14 |
2010-10-26 |
City Of Hope |
Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
|
|
US7928218B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
|
|
AU2003220136A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US7893248B2
(en)
|
2002-02-20 |
2011-02-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
|
|
US20090247613A1
(en)
*
|
2002-02-20 |
2009-10-01 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
EP1501853A4
(en)
*
|
2002-02-20 |
2005-11-16 |
Sirna Therapeutics Inc |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION OF AN EPIDERMAL GROWTH FACTOR RECEPTOR USING SHORT INTERFERING NUCLEIC ACIDS
|
|
US20090093439A1
(en)
*
|
2002-02-20 |
2009-04-09 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20090253774A1
(en)
|
2002-02-20 |
2009-10-08 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF PLATELET DERIVED GROWTH FACTOR (PDGF) AND PLATELET DERIVED GROWTH FACTOR RECEPTOR (PDGFR) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US7910724B2
(en)
|
2002-02-20 |
2011-03-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
|
|
US7700760B2
(en)
|
2002-02-20 |
2010-04-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
|
|
US20100240730A1
(en)
*
|
2002-02-20 |
2010-09-23 |
Merck Sharp And Dohme Corp. |
RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
|
|
AU2003213005A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc |
RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US7667030B2
(en)
|
2002-02-20 |
2010-02-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
|
US7662952B2
(en)
|
2002-02-20 |
2010-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)
|
|
US7795422B2
(en)
|
2002-02-20 |
2010-09-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
|
US7928220B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)
|
|
US7897753B2
(en)
|
2002-02-20 |
2011-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA)
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20090192105A1
(en)
|
2002-02-20 |
2009-07-30 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA)
|
|
US7928219B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA)
|
|
US20090306182A1
(en)
*
|
2002-02-20 |
2009-12-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MAP KINASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
EP1474433A4
(en)
*
|
2002-02-20 |
2005-02-23 |
Sirna Therapeutics Inc |
TARGET LOCALIZATION TARGETED BY RNA INTERFERENCE AND TARGET VALIDATION WITH SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20050096284A1
(en)
*
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US7897757B2
(en)
|
2002-02-20 |
2011-03-01 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
|
|
US7678897B2
(en)
|
2002-02-20 |
2010-03-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
|
|
US20090233983A1
(en)
*
|
2002-02-20 |
2009-09-17 |
Sirna Therapeutics Inc. |
RNA Interference Mediated Inhibition of Protein Tyrosine Phosphatase-1B (PTP-1B) Gene Expression Using Short Interfering RNA
|
|
EP1432724A4
(en)
|
2002-02-20 |
2006-02-01 |
Sirna Therapeutics Inc |
RNA inhibition mediated inhibition of MAP KINASE GENES
|
|
WO2003106476A1
(en)
*
|
2002-02-20 |
2003-12-24 |
Sirna Therapeutics, Inc |
Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity
|
|
US7935812B2
(en)
|
2002-02-20 |
2011-05-03 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
|
US7897752B2
(en)
|
2002-02-20 |
2011-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
|
|
US7683166B2
(en)
*
|
2002-02-20 |
2010-03-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
|
AU2003219817B2
(en)
*
|
2002-02-20 |
2006-08-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis C virus
|
|
AU2003216265A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Ribozyme Pharmaceuticals, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF G72 AND D-AMINO ACID OXIDASE (DAAO) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20090099117A1
(en)
|
2002-02-20 |
2009-04-16 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MYOSTATIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20090137509A1
(en)
*
|
2002-02-20 |
2009-05-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF PROLIFERATION CELL NUCLEAR ANTIGEN (PCNA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US8067575B2
(en)
|
2002-02-20 |
2011-11-29 |
Merck, Sharp & Dohme Corp. |
RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
|
|
US8232383B2
(en)
*
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
EP1478730A4
(en)
*
|
2002-02-20 |
2006-01-25 |
Sirna Therapeutics Inc |
INTERFERENCE RNA-INDUCED INHIBITION OF THE GENE EXPRESSION OF SUPERFAMILY TFN AND TFN RECEPTOR SUPERFAMILY USING SHORT INTERFERENCE NUCLEIC ACID (SINA)
|
|
US8258288B2
(en)
|
2002-02-20 |
2012-09-04 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA)
|
|
US7683165B2
(en)
|
2002-02-20 |
2010-03-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
|
US8013143B2
(en)
*
|
2002-02-20 |
2011-09-06 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
|
|
US20090253773A1
(en)
|
2002-02-20 |
2009-10-08 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US7667029B2
(en)
|
2002-02-20 |
2010-02-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
|
|
US7691999B2
(en)
|
2002-02-20 |
2010-04-06 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA)
|
|
AU2003219900A1
(en)
*
|
2002-02-22 |
2003-09-09 |
James R. Eshleman |
Antigene locks and therapeutic uses thereof
|
|
AU2003223214B2
(en)
*
|
2002-03-01 |
2008-09-18 |
Celltech R & D, Inc. |
Methods to increase or decrease bone density
|
|
WO2003076592A2
(en)
*
|
2002-03-06 |
2003-09-18 |
Rigel Pharmaceuticals, Inc. |
Novel method for delivery and intracellular synthesis of sirna molecules
|
|
US7274703B2
(en)
*
|
2002-03-11 |
2007-09-25 |
3Com Corporation |
Stackable network units with resiliency facility
|
|
AU2003224725A1
(en)
*
|
2002-03-20 |
2003-10-08 |
Brigham And Women's Hospital, Inc. |
Hiv therapeutic
|
|
US7357928B2
(en)
|
2002-04-08 |
2008-04-15 |
University Of Louisville Research Foundation, Inc. |
Method for the diagnosis and prognosis of malignant diseases
|
|
EP1495120B1
(en)
*
|
2002-04-18 |
2012-10-10 |
Acuity Pharmaceuticals, Inc |
Means and methods for the specific modulation of target genes in the eye
|
|
US8137910B2
(en)
|
2002-05-03 |
2012-03-20 |
Duke University |
Method of regulating gene expression
|
|
US7199107B2
(en)
*
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
|
US7399586B2
(en)
|
2002-05-23 |
2008-07-15 |
Ceptyr, Inc. |
Modulation of biological signal transduction by RNA interference
|
|
AU2003237686A1
(en)
*
|
2002-05-24 |
2003-12-12 |
Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Rna interference mediating small rna molecules
|
|
GB2406169B
(en)
*
|
2002-06-12 |
2006-11-01 |
Ambion Inc |
Methods and compositions relating to labeled rna molecules that reduce gene expression
|
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
|
WO2003106636A2
(en)
*
|
2002-06-14 |
2003-12-24 |
Mirus Corporation |
Novel methods for the delivery of polynucleotides to cells
|
|
WO2004001044A1
(en)
*
|
2002-06-21 |
2003-12-31 |
Sinogenomax Company Ltd. |
Randomised dna libraries and double-stranded rna libraries, use and method of production thereof
|
|
AU2003256325A1
(en)
*
|
2002-06-26 |
2004-01-19 |
The Penn State Research Foundation |
Methods and materials for treating human papillomavirus infections
|
|
EP1519714B1
(en)
|
2002-06-28 |
2010-10-20 |
Protiva Biotherapeutics Inc. |
Method and apparatus for producing liposomes
|
|
US8101348B2
(en)
|
2002-07-10 |
2012-01-24 |
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. |
RNA-interference by single-stranded RNA molecules
|
|
US7148342B2
(en)
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
|
AU2015264957B2
(en)
*
|
2002-08-05 |
2017-10-26 |
Silence Therapeutics Gmbh |
Further novel forms of interfering rna molecules
|
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
|
AU2012216354B2
(en)
*
|
2002-08-05 |
2016-01-14 |
Silence Therapeutics Gmbh |
Further novel forms of interfering RNA molecules
|
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
|
US20040241854A1
(en)
|
2002-08-05 |
2004-12-02 |
Davidson Beverly L. |
siRNA-mediated gene silencing
|
|
DK1389637T3
(da)
|
2002-08-05 |
2012-09-03 |
Silence Therapeutics Ag |
Interfererende RNA-molekyler med stumpe ender
|
|
DE60310944T3
(de)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Weitere neue formen von interferierende rns moleküle
|
|
TR201816291T4
(tr)
*
|
2002-08-05 |
2018-11-21 |
Silence Therapeutics Gmbh |
Müdahaleci rna moleküllerinin ilave yeni biçimleri.
|
|
AU2003258100A1
(en)
*
|
2002-08-06 |
2004-02-23 |
Intradigm Corporation |
Methods of down regulating target gene expression in vivo by introduction of interfering rna
|
|
CA2501719C
(en)
*
|
2002-08-06 |
2013-02-05 |
Toray Industries, Inc. |
Remedy or preventive for kidney disease and method of diagnosing kidney disease
|
|
AU2003261449A1
(en)
*
|
2002-08-07 |
2004-02-25 |
|
Compositions for rna interference and methods of use thereof
|
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
|
PT1536827E
(pt)
*
|
2002-08-14 |
2009-03-20 |
Silence Therapeutics Ag |
Utilização de proteína cinase n beta
|
|
KR101238701B1
(ko)
*
|
2002-08-21 |
2013-03-05 |
더 유니버시티 오브 브리티쉬 콜롬비아 |
암-관련 단백질을 표적으로 하는 알엔에이아이 프로브
|
|
US7923547B2
(en)
*
|
2002-09-05 |
2011-04-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20060287269A1
(en)
*
|
2002-09-09 |
2006-12-21 |
The Regents Of The University Of California |
Short interfering nucleic acid hybrids and methods thereof
|
|
US20080260744A1
(en)
|
2002-09-09 |
2008-10-23 |
Omeros Corporation |
G protein coupled receptors and uses thereof
|
|
US20040138119A1
(en)
*
|
2002-09-18 |
2004-07-15 |
Ingo Tamm |
Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis
|
|
US20060257380A1
(en)
*
|
2002-09-19 |
2006-11-16 |
Inst.Nat. De La Sante Et De La Recherche MED |
Use of sirnas for gene silencing in antigen presenting cells
|
|
CA2881743A1
(en)
|
2002-09-25 |
2004-04-08 |
University Of Massachusetts |
In vivo gene silencing by chemically modified and stable sirna
|
|
US20050008617A1
(en)
*
|
2002-09-28 |
2005-01-13 |
Massachusetts Institute Of Technology |
Compositions and methods for delivery of short interfering RNA and short hairpin RNA
|
|
US20040242518A1
(en)
*
|
2002-09-28 |
2004-12-02 |
Massachusetts Institute Of Technology |
Influenza therapeutic
|
|
US20060160759A1
(en)
*
|
2002-09-28 |
2006-07-20 |
Jianzhu Chen |
Influenza therapeutic
|
|
US20060240425A1
(en)
*
|
2002-09-30 |
2006-10-26 |
Oncotherapy Science, Inc |
Genes and polypeptides relating to myeloid leukemia
|
|
US7422853B1
(en)
*
|
2002-10-04 |
2008-09-09 |
Myriad Genetics, Inc. |
RNA interference using a universal target
|
|
ZA200502612B
(en)
|
2002-10-08 |
2007-07-25 |
Rinat Neuroscience Corp |
Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same
|
|
WO2005000194A2
(en)
|
2002-10-08 |
2005-01-06 |
Rinat Neuroscience Corp. |
Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same
|
|
NZ540779A
(en)
*
|
2002-11-01 |
2008-05-30 |
Univ Pennsylvania |
Compositions and methods for siRNA inhibition of HIF-1 alpha
|
|
US7892793B2
(en)
|
2002-11-04 |
2011-02-22 |
University Of Massachusetts |
Allele-specific RNA interference
|
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
WO2004041889A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
AU2003287464A1
(en)
*
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
2'-fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
|
DE10322662A1
(de)
*
|
2002-11-06 |
2004-10-07 |
Grünenthal GmbH |
Wirksame und stabile DNA-Enzyme
|
|
US7635770B2
(en)
|
2002-11-14 |
2009-12-22 |
Dharmacon, Inc. |
siRNA targeting protein kinase N-3 (PKN-3)
|
|
US7592442B2
(en)
|
2002-11-14 |
2009-09-22 |
Dharmacon, Inc. |
siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2)
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
US10011836B2
(en)
|
2002-11-14 |
2018-07-03 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
US9771586B2
(en)
|
2002-11-14 |
2017-09-26 |
Thermo Fisher Scientific Inc. |
RNAi targeting ZNF205
|
|
US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
US7655785B1
(en)
|
2002-11-14 |
2010-02-02 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
|
US8198427B1
(en)
|
2002-11-14 |
2012-06-12 |
Dharmacon, Inc. |
SiRNA targeting catenin, beta-1 (CTNNB1)
|
|
US20090227780A1
(en)
*
|
2002-11-14 |
2009-09-10 |
Dharmacon, Inc. |
siRNA targeting connexin 43
|
|
US7977471B2
(en)
*
|
2002-11-14 |
2011-07-12 |
Dharmacon, Inc. |
siRNA targeting TNFα
|
|
US7951935B2
(en)
|
2002-11-14 |
2011-05-31 |
Dharmacon, Inc. |
siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)
|
|
US20100113307A1
(en)
*
|
2002-11-14 |
2010-05-06 |
Dharmacon, Inc. |
siRNA targeting vascular endothelial growth factor (VEGF)
|
|
US7612196B2
(en)
*
|
2002-11-14 |
2009-11-03 |
Dharmacon, Inc. |
siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
|
|
US9719092B2
(en)
|
2002-11-14 |
2017-08-01 |
Thermo Fisher Scientific Inc. |
RNAi targeting CNTD2
|
|
US7691998B2
(en)
|
2002-11-14 |
2010-04-06 |
Dharmacon, Inc. |
siRNA targeting nucleoporin 62kDa (Nup62)
|
|
US8163896B1
(en)
|
2002-11-14 |
2012-04-24 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US9719094B2
(en)
|
2002-11-14 |
2017-08-01 |
Thermo Fisher Scientific Inc. |
RNAi targeting SEC61G
|
|
US9839649B2
(en)
|
2002-11-14 |
2017-12-12 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
US20090005548A1
(en)
*
|
2002-11-14 |
2009-01-01 |
Dharmacon, Inc. |
siRNA targeting nuclear receptor interacting protein 1 (NRIP1)
|
|
US7781575B2
(en)
|
2002-11-14 |
2010-08-24 |
Dharmacon, Inc. |
siRNA targeting tumor protein 53 (p53)
|
|
US10920226B2
(en)
*
|
2002-11-14 |
2021-02-16 |
Thermo Fisher Scientific Inc. |
siRNA targeting LDHA
|
|
AU2003295600A1
(en)
*
|
2002-11-14 |
2004-06-15 |
Dharmacon, Inc. |
Functional and hyperfunctional sirna
|
|
US7619081B2
(en)
|
2002-11-14 |
2009-11-17 |
Dharmacon, Inc. |
siRNA targeting coatomer protein complex, subunit beta 2 (COPB2)
|
|
US20080268457A1
(en)
*
|
2002-11-14 |
2008-10-30 |
Dharmacon, Inc. |
siRNA targeting forkhead box P3 (FOXP3)
|
|
US9879266B2
(en)
|
2002-11-14 |
2018-01-30 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
EP1613724A4
(en)
|
2002-11-18 |
2010-09-01 |
Us Gov Health & Human Serv |
CELL LINES AND NUCLEAR ACIDIC ACIDS IN CONNECTION WITH INFECTION DISEASES
|
|
US7064337B2
(en)
|
2002-11-19 |
2006-06-20 |
The Regents Of The University Of California |
Radiation detection system for portable gamma-ray spectroscopy
|
|
DE10254214A1
(de)
*
|
2002-11-20 |
2004-06-09 |
Beiersdorf Ag |
Oligoribonukleotide zur Behandlung von degenerativen Hauterscheinungen durch RNA-Interferenz
|
|
JP3839453B2
(ja)
*
|
2002-11-22 |
2006-11-01 |
株式会社バイオシンクタンク |
Rna干渉の標的塩基配列検索方法、rna干渉を生じさせるポリヌクレオチドの塩基配列設計方法、2本鎖ポリヌクレオチドの作製方法、遺伝子の発現抑制方法、塩基配列処理装置、塩基配列処理方法をコンピュータに実行させるプログラム、記録媒体、および、塩基配列処理システム
|
|
JP4526228B2
(ja)
*
|
2002-11-22 |
2010-08-18 |
隆 森田 |
RNAiによる新規治療法および治療剤
|
|
AU2003298718A1
(en)
*
|
2002-11-22 |
2004-06-18 |
University Of Massachusetts |
Modulation of hiv replication by rna interference
|
|
US7618948B2
(en)
|
2002-11-26 |
2009-11-17 |
Medtronic, Inc. |
Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
|
|
EP1585756B1
(en)
*
|
2002-11-26 |
2010-04-21 |
University of Massachusetts |
Delivery of sirnas
|
|
US20130130231A1
(en)
|
2002-11-26 |
2013-05-23 |
Isaac Bentwich |
Bioinformatically detectable group of novel viral regulatory genes and uses thereof
|
|
US7217807B2
(en)
|
2002-11-26 |
2007-05-15 |
Rosetta Genomics Ltd |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
|
|
US7605249B2
(en)
|
2002-11-26 |
2009-10-20 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
|
US7696334B1
(en)
|
2002-12-05 |
2010-04-13 |
Rosetta Genomics, Ltd. |
Bioinformatically detectable human herpesvirus 5 regulatory gene
|
|
US7829694B2
(en)
|
2002-11-26 |
2010-11-09 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
|
CN1301263C
(zh)
|
2002-12-18 |
2007-02-21 |
北京昭衍新药研究中心 |
一组抗hiv感染及防治艾滋病的核苷酸序列及其应用
|
|
US9498530B2
(en)
|
2002-12-24 |
2016-11-22 |
Rinat Neuroscience Corp. |
Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
|
|
DK2270048T3
(en)
|
2002-12-24 |
2016-01-18 |
Rinat Neuroscience Corp |
Anti-NGF antibodies and methods for their use
|
|
US7569364B2
(en)
|
2002-12-24 |
2009-08-04 |
Pfizer Inc. |
Anti-NGF antibodies and methods using same
|
|
WO2004063331A2
(en)
*
|
2003-01-03 |
2004-07-29 |
Gencia Corporation |
SiRNA MEDIATED POST-TRANSRIPTIONAL GENE SILENCING OF GENES INVOLVED IN ALOPECIA
|
|
JP2007524349A
(ja)
*
|
2003-01-16 |
2007-08-30 |
ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア |
ICAM−1のsiRNA阻害のための組成物及び方法
|
|
US7629323B2
(en)
*
|
2003-01-21 |
2009-12-08 |
Northwestern University |
Manipulation of neuronal ion channels
|
|
US20060178297A1
(en)
*
|
2003-01-28 |
2006-08-10 |
Troy Carol M |
Systems and methods for silencing expression of a gene in a cell and uses thereof
|
|
US20040147027A1
(en)
*
|
2003-01-28 |
2004-07-29 |
Troy Carol M. |
Complex for facilitating delivery of dsRNA into a cell and uses thereof
|
|
US7732591B2
(en)
|
2003-11-25 |
2010-06-08 |
Medtronic, Inc. |
Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
|
|
US7994149B2
(en)
|
2003-02-03 |
2011-08-09 |
Medtronic, Inc. |
Method for treatment of Huntington's disease through intracranial delivery of sirna
|
|
WO2004071430A2
(en)
*
|
2003-02-05 |
2004-08-26 |
University Of Massachusetts |
RNAi TARGETING OF VIRUSES
|
|
FR2850971B1
(fr)
*
|
2003-02-10 |
2006-08-11 |
Aventis Pharma Sa |
Oligonucleotide antisens inhibant l'expression de la proteine ob-rgrp et procede de detection de composes modifiant l'interaction entre la famille de la proteine ob-rgrp et le recepteur de la leptine
|
|
US20070104688A1
(en)
|
2003-02-13 |
2007-05-10 |
City Of Hope |
Small interfering RNA mediated transcriptional gene silencing in mammalian cells
|
|
US20040162235A1
(en)
*
|
2003-02-18 |
2004-08-19 |
Trubetskoy Vladimir S. |
Delivery of siRNA to cells using polyampholytes
|
|
BRPI0407375A
(pt)
|
2003-02-19 |
2006-02-07 |
Rinat Neuroscience Corp |
Métodos para tratar dor por meio da administração de um antagonista do fator de crescimento neural e u nsaid e composições contendo os mesmos
|
|
WO2005017127A2
(en)
*
|
2003-02-21 |
2005-02-24 |
The Penn State Research Foundation |
Rna interference compositions and methods
|
|
US8796235B2
(en)
*
|
2003-02-21 |
2014-08-05 |
University Of South Florida |
Methods for attenuating dengue virus infection
|
|
ATE554185T1
(de)
|
2003-02-27 |
2012-05-15 |
Alnylam Pharmaceuticals Inc |
Verfahren und konstrukte zur bewertung von rnai- zielen und effektormolekülen
|
|
WO2004076663A1
(ja)
*
|
2003-02-27 |
2004-09-10 |
National Institute Of Advanced Industrial Science And Technology |
哺乳動物細胞におけるdsRNAによるCpG配列へのメチル化誘導
|
|
AU2004217437B2
(en)
*
|
2003-03-05 |
2009-11-19 |
Senesco Technologies, Inc. |
Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
|
|
WO2004078941A2
(en)
*
|
2003-03-06 |
2004-09-16 |
Oligo Engine, Inc. |
Modulation of gene expression using dna-rna hybrids
|
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
|
EP1606305A4
(en)
*
|
2003-03-12 |
2009-06-24 |
Vasgene Therapeutics Inc |
NUCLEIC ACID COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND TUMOR GROWTH
|
|
ATE443765T1
(de)
|
2003-03-21 |
2009-10-15 |
Santaris Pharma As |
Analoga kurzer interferierender rna (sirna)
|
|
US20040198640A1
(en)
*
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
|
JP4605799B2
(ja)
*
|
2003-04-02 |
2011-01-05 |
ダーマコン, インコーポレイテッド |
Rna干渉において使用するための修飾ポリヌクレオチド
|
|
ATE536408T1
(de)
*
|
2003-04-02 |
2011-12-15 |
Dharmacon Inc |
Modifizierte polynukleotide zur verwendung bei rna-interferenz
|
|
WO2004091572A2
(en)
|
2003-04-09 |
2004-10-28 |
Biodelivery Sciences International, Inc. |
Cochleate compositions directed against expression of proteins
|
|
CA2521464C
(en)
|
2003-04-09 |
2013-02-05 |
Alnylam Pharmaceuticals, Inc. |
Irna conjugates
|
|
WO2004092383A2
(en)
*
|
2003-04-15 |
2004-10-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS) VIRUS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
US7723509B2
(en)
|
2003-04-17 |
2010-05-25 |
Alnylam Pharmaceuticals |
IRNA agents with biocleavable tethers
|
|
US8017762B2
(en)
|
2003-04-17 |
2011-09-13 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
|
JP4991288B2
(ja)
|
2003-04-17 |
2012-08-01 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
二本鎖iRNA剤、および二本鎖iRNA剤の対合の安定性を調節する方法。
|
|
US8796436B2
(en)
|
2003-04-17 |
2014-08-05 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
AU2004233043A1
(en)
*
|
2003-04-18 |
2004-11-04 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for siRNA inhibition of angiopoietin 1 and 2 and their receptor Tie2
|
|
WO2005032595A2
(en)
*
|
2003-04-23 |
2005-04-14 |
Georgetown University |
Methods and compositions for the inhibition of stat5 in prostate cancer cells
|
|
US9701725B2
(en)
*
|
2003-05-05 |
2017-07-11 |
The Johns Hopkins University |
Anti-cancer DNA vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
|
|
WO2004101756A2
(en)
|
2003-05-09 |
2004-11-25 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
|
CA2523785A1
(en)
|
2003-05-09 |
2004-11-25 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Small interfering rna libraries and methods of synthesis and use
|
|
AU2003241409A1
(en)
*
|
2003-05-12 |
2005-01-21 |
Potomac Pharmaceuticals, Inc. |
Gene expression suppression agents
|
|
US20050148531A1
(en)
*
|
2003-05-15 |
2005-07-07 |
Todd Hauser |
Modulation of gene expression using DNA-DNA hybrids
|
|
WO2005018534A2
(en)
*
|
2003-05-16 |
2005-03-03 |
Rosetta Inpharmatics, Llc |
Methods and compositions for rna interference
|
|
JP4299299B2
(ja)
*
|
2003-05-19 |
2009-07-22 |
株式会社ジーンケア研究所 |
癌細胞に対するアポトーシス誘導剤
|
|
WO2004106511A1
(ja)
|
2003-05-30 |
2004-12-09 |
Nippon Shinyaku Co., Ltd. |
Bcl−2の発現抑制をするオリゴ二本鎖RNAとそれを含有する医薬組成物
|
|
EP1637144A4
(en)
*
|
2003-05-30 |
2010-01-13 |
Nippon Shinyaku Co Ltd |
OLIGONUCLEIC ACID CONTAINING COMPOSITE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
|
|
PT1633767T
(pt)
|
2003-06-02 |
2019-02-27 |
Univ Massachusetts |
Métodos e composições para controlar a eficácia do silenciamento de arn
|
|
US7750144B2
(en)
*
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
EP1633890B2
(en)
*
|
2003-06-02 |
2020-11-18 |
University of Massachusetts |
METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi
|
|
JP4579911B2
(ja)
|
2003-06-03 |
2010-11-10 |
アイシス・ファーマシューティカルズ・インコーポレイテッド |
スルビビン発現の調節
|
|
US20050019918A1
(en)
*
|
2003-06-03 |
2005-01-27 |
Hidetoshi Sumimoto |
Treatment of cancer by inhibiting BRAF expression
|
|
US7595306B2
(en)
*
|
2003-06-09 |
2009-09-29 |
Alnylam Pharmaceuticals Inc |
Method of treating neurodegenerative disease
|
|
US8575327B2
(en)
|
2003-06-12 |
2013-11-05 |
Alnylam Pharmaceuticals, Inc. |
Conserved HBV and HCV sequences useful for gene silencing
|
|
EP1486564A1
(de)
*
|
2003-06-13 |
2004-12-15 |
Ribopharma AG |
SiRNA mit erhöhter Stabilität in Serum
|
|
AU2004263830B2
(en)
|
2003-06-13 |
2008-12-18 |
Alnylam Pharmaceuticals, Inc. |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
|
EP1644475A4
(en)
*
|
2003-06-20 |
2009-06-03 |
Isis Pharmaceuticals Inc |
DOUBLE-STRAND COMPOSITIONS WITH A 3'-ENDO-MODIFIED STRING FOR USE IN GENE MODULATION
|
|
EP1636342A4
(en)
*
|
2003-06-20 |
2008-10-08 |
Isis Pharmaceuticals Inc |
OLIGOMER COMPOUNDS FOR USE IN THE MODULATION OF GENES
|
|
EP1692153A4
(en)
*
|
2003-07-03 |
2007-03-21 |
Univ Pennsylvania |
INHIBITION OF EXPRESSION OF SYK-KINASE
|
|
US20050136430A1
(en)
*
|
2003-07-15 |
2005-06-23 |
California Institute Of Technology |
Inhibitor nucleic acids
|
|
US20050256071A1
(en)
*
|
2003-07-15 |
2005-11-17 |
California Institute Of Technology |
Inhibitor nucleic acids
|
|
CA2532228C
(en)
*
|
2003-07-16 |
2017-02-14 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
WO2005010188A2
(en)
*
|
2003-07-21 |
2005-02-03 |
Whitehead Institute For Biomedical Research |
Rnas able to modulate chromatin silencing
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
WO2005019422A2
(en)
*
|
2003-08-13 |
2005-03-03 |
The Board Of Trustees Of The University Of Illinois |
Silencing of tgf-beta receptor type ii expression by sirna
|
|
US7888497B2
(en)
|
2003-08-13 |
2011-02-15 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
|
US7825235B2
(en)
*
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
WO2005035759A2
(en)
*
|
2003-08-20 |
2005-04-21 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HYPOXIA INDUCIBLE FACTOR 1 (HIF1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20050136437A1
(en)
*
|
2003-08-25 |
2005-06-23 |
Nastech Pharmaceutical Company Inc. |
Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
|
|
EP1660657A1
(en)
|
2003-08-28 |
2006-05-31 |
Novartis AG |
Interfering rna duplex having blunt-ends and 3'-modifications
|
|
US8501705B2
(en)
*
|
2003-09-11 |
2013-08-06 |
The Board Of Regents Of The University Of Texas System |
Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
|
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
DK2821085T3
(da)
*
|
2003-09-12 |
2020-08-03 |
Univ Massachusetts |
Rna-interferens til behandling af "gain-of-function"-forstyrrelser
|
|
EP2256201A3
(en)
|
2003-09-18 |
2012-07-04 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E expression
|
|
EP1670955A2
(en)
*
|
2003-09-22 |
2006-06-21 |
Rosetta Inpharmatics LLC. |
Synthetic lethal screen using rna interference
|
|
WO2005033310A1
(de)
*
|
2003-10-01 |
2005-04-14 |
Grünenthal GmbH |
Pim-1-spezifische dsrna-verbindungen
|
|
US20080249038A1
(en)
*
|
2003-10-07 |
2008-10-09 |
Quark Biotech, Inc. |
Bone Morphogenetic Protein (Bmp) 2A and Uses Thereof
|
|
US20050120415A1
(en)
|
2003-10-09 |
2005-06-02 |
E.I. Du Pont De Nemours And Company |
Gene silencing
|
|
WO2005045032A2
(en)
*
|
2003-10-20 |
2005-05-19 |
Sima Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF EARLY GROWTH RESPONSE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
WO2005044981A2
(en)
*
|
2003-10-23 |
2005-05-19 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
|
CA2543029A1
(en)
*
|
2003-10-23 |
2005-05-19 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gpra and aaa1 gene expression using short nucleic acid (sina)
|
|
CN1926551B
(zh)
|
2003-10-27 |
2010-06-16 |
罗斯塔生化科技有限责任公司 |
用于基因沉默的siRNA的设计方法
|
|
US8227434B1
(en)
|
2003-11-04 |
2012-07-24 |
H. Lee Moffitt Cancer Center & Research Institute, Inc. |
Materials and methods for treating oncological disorders
|
|
US20070275918A1
(en)
*
|
2003-11-07 |
2007-11-29 |
The Board Of Trustees Of The University Of Illinois |
Induction of Cellular Senescence by Cdk4 Disruption for Tumor Suppression and Regression
|
|
WO2005047507A1
(en)
*
|
2003-11-12 |
2005-05-26 |
The Austin Research Institute |
Dna-carrier conjugate
|
|
US7763592B1
(en)
|
2003-11-20 |
2010-07-27 |
University Of South Florida |
SHIP-deficiency to increase megakaryocyte progenitor production
|
|
JP2005168485A
(ja)
*
|
2003-11-20 |
2005-06-30 |
Tsutomu Suzuki |
siRNAの設計方法
|
|
US7807646B1
(en)
*
|
2003-11-20 |
2010-10-05 |
University Of South Florida |
SHIP-deficiency to increase megakaryocyte progenitor production
|
|
US20050208658A1
(en)
*
|
2003-11-21 |
2005-09-22 |
The University Of Maryland |
RNA interference mediated inhibition of 11beta hydroxysteriod dehydrogenase-1 (11beta HSD-1) gene expression
|
|
US20100145038A1
(en)
*
|
2003-11-24 |
2010-06-10 |
Merck & Co., Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
GB2424887B
(en)
*
|
2003-11-26 |
2008-05-21 |
Univ Massachusetts |
Sequence-specific inhibition of small RNA function
|
|
US20080171051A1
(en)
*
|
2003-11-26 |
2008-07-17 |
Patrick Gerard Johnston |
Cancer Treatment
|
|
CA2548150A1
(en)
*
|
2003-12-04 |
2005-06-23 |
University Of South Florida |
Polynucleotides for reducing respiratory syncytial virus gene expression
|
|
JP2007513968A
(ja)
*
|
2003-12-12 |
2007-05-31 |
ウイスコンシン アラムニ リサーチ ファンデーション |
哺乳動物神経細胞へのsiRNAのデリバリー
|
|
JPWO2005068630A1
(ja)
*
|
2003-12-16 |
2007-07-26 |
独立行政法人産業技術総合研究所 |
干渉用二重鎖rna
|
|
US20060134787A1
(en)
|
2004-12-22 |
2006-06-22 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
|
|
AU2004308484A1
(en)
*
|
2003-12-23 |
2005-07-14 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for combined therapy of disease
|
|
JP4767019B2
(ja)
*
|
2004-01-16 |
2011-09-07 |
武田薬品工業株式会社 |
動脈硬化の予防・治療用医薬
|
|
WO2005072057A2
(en)
|
2004-01-30 |
2005-08-11 |
Quark Biotech, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
|
|
WO2005073378A1
(en)
*
|
2004-01-30 |
2005-08-11 |
Santaris Pharma A/S |
MODIFIED SHORT INTERFERING RNA (MODIFIED siRNA)
|
|
WO2005078094A2
(en)
*
|
2004-02-06 |
2005-08-25 |
Dharmacon, Inc. |
Stabilized rnas as transfection controls and silencing reagents
|
|
ATE452188T1
(de)
*
|
2004-02-10 |
2010-01-15 |
Sirna Therapeutics Inc |
Rna-interferenz-vermittelte hemmung der genexpression unter verwendung multifunktioneller sina (short interfering nucleic acid)
|
|
US20060019914A1
(en)
|
2004-02-11 |
2006-01-26 |
University Of Tennessee Research Foundation |
Inhibition of tumor growth and invasion by anti-matrix metalloproteinase DNAzymes
|
|
US20060069050A1
(en)
*
|
2004-02-17 |
2006-03-30 |
University Of Massachusetts |
Methods and compositions for mediating gene silencing
|
|
WO2005079532A2
(en)
*
|
2004-02-17 |
2005-09-01 |
University Of Massachusetts |
Methods and compositions for enhancing risc activity in vitro and in vivo
|
|
JP2007523214A
(ja)
*
|
2004-02-23 |
2007-08-16 |
ジェンザイム コーポレイション |
デスレセプターリガンド誘導アポトーシスのmuc1アンタゴニスト増強方法
|
|
EP1566202A1
(en)
*
|
2004-02-23 |
2005-08-24 |
Sahltech I Göteborg AB |
Use of resistin antagonists in the treatment of rheumatoid arthritis
|
|
US20070087008A1
(en)
|
2004-02-24 |
2007-04-19 |
The Government Of The United States Of America As |
Rab9a, rab11a, and modulators thereof related to infectious disease
|
|
US7691823B2
(en)
*
|
2004-03-05 |
2010-04-06 |
University Of Massachusetts |
RIP140 regulation of glucose transport
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
US20050202075A1
(en)
*
|
2004-03-12 |
2005-09-15 |
Pardridge William M. |
Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers
|
|
ES2423060T3
(es)
|
2004-03-12 |
2013-09-17 |
Alnylam Pharmaceuticals, Inc. |
Agentes iRNA que tienen como diana al VEGF
|
|
US20070265220A1
(en)
|
2004-03-15 |
2007-11-15 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
|
CA2559955C
(en)
*
|
2004-03-15 |
2016-02-16 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded rna
|
|
US20050208090A1
(en)
*
|
2004-03-18 |
2005-09-22 |
Medtronic, Inc. |
Methods and systems for treatment of neurological diseases of the central nervous system
|
|
US20050272682A1
(en)
*
|
2004-03-22 |
2005-12-08 |
Evers Bernard M |
SiRNA targeting PI3K signal transduction pathway and siRNA-based therapy
|
|
US7851452B2
(en)
*
|
2004-03-22 |
2010-12-14 |
The Trustees Of The University Of Pennsylvania |
Methods of use of bcl-6-derived nucleotides to induce apoptosis
|
|
WO2005097207A2
(en)
*
|
2004-03-26 |
2005-10-20 |
Curis, Inc. |
Rna interference modulators of hedgehog signaling and uses thereof
|
|
WO2005095622A2
(en)
*
|
2004-03-26 |
2005-10-13 |
Van Andel Research Institute |
c-met siRNA ADENOVIRUS VECTORS INHIBIT CANCER CELL GROWTH, INVASION AND TUMORIGENICITY
|
|
WO2005095647A1
(ja)
*
|
2004-03-31 |
2005-10-13 |
Takara Bio Inc. |
siRNAのスクリーニング方法
|
|
JP2005312428A
(ja)
*
|
2004-03-31 |
2005-11-10 |
Keio Gijuku |
Skp−2発現抑制を利用した癌の治療
|
|
KR101147147B1
(ko)
*
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
JP2007531794A
(ja)
|
2004-04-05 |
2007-11-08 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
|
|
EP3372614B1
(en)
|
2004-04-07 |
2022-06-08 |
Rinat Neuroscience Corp. |
Methods for treating bone cancer pain by administering a nerve growth factor antagonist
|
|
EP2520652B1
(en)
|
2004-04-09 |
2015-06-10 |
Genecare Research Institute Co., Ltd |
Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associates genes
|
|
US20060078902A1
(en)
*
|
2004-04-15 |
2006-04-13 |
Michaeline Bunting |
Method and compositions for RNA interference
|
|
US20060014289A1
(en)
*
|
2004-04-20 |
2006-01-19 |
Nastech Pharmaceutical Company Inc. |
Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
|
|
EP1747022A4
(en)
|
2004-04-23 |
2010-03-31 |
Univ Columbia |
INHIBITION OF HAIRLESS PROTEIN MRNA
|
|
EP1768998A2
(en)
|
2004-04-27 |
2007-04-04 |
Alnylam Pharmaceuticals Inc. |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
|
|
US8029815B2
(en)
|
2004-04-28 |
2011-10-04 |
Elford Howard L |
Methods for treating or preventing restenosis and other vascular proliferative disorders
|
|
AU2005323437B2
(en)
|
2004-04-30 |
2011-10-06 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a C5-modified pyrimidine
|
|
US20060040882A1
(en)
*
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
|
WO2006069782A2
(en)
|
2004-12-27 |
2006-07-06 |
Silence Therapeutics Ag. |
Lipid complexes coated with peg and their use
|
|
US20060030003A1
(en)
*
|
2004-05-12 |
2006-02-09 |
Simon Michael R |
Composition and method for introduction of RNA interference sequences into targeted cells and tissues
|
|
US7605250B2
(en)
*
|
2004-05-12 |
2009-10-20 |
Dharmacon, Inc. |
siRNA targeting cAMP-specific phosphodiesterase 4D
|
|
US20110117088A1
(en)
*
|
2004-05-12 |
2011-05-19 |
Simon Michael R |
Composition and method for introduction of rna interference sequences into targeted cells and tissues
|
|
US20050260214A1
(en)
*
|
2004-05-12 |
2005-11-24 |
Simon Michael R |
Composition and method for introduction of RNA interference sequences into targeted cells and tissues
|
|
WO2005110464A2
(en)
*
|
2004-05-14 |
2005-11-24 |
Oregon Health & Science University |
Irx5 inhibition as treatment for hyperproliferative disorders
|
|
US7687616B1
(en)
|
2004-05-14 |
2010-03-30 |
Rosetta Genomics Ltd |
Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
|
|
JP5697297B2
(ja)
|
2004-05-14 |
2015-04-08 |
ロゼッタ ジノミクス リミテッド |
マイクロnasおよびその使用
|
|
US10508277B2
(en)
|
2004-05-24 |
2019-12-17 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
|
EP1773303A2
(en)
*
|
2004-05-25 |
2007-04-18 |
Chimeracore, Inc. |
Self-assembling nanoparticle drug delivery system
|
|
US7795419B2
(en)
*
|
2004-05-26 |
2010-09-14 |
Rosetta Genomics Ltd. |
Viral and viral associated miRNAs and uses thereof
|
|
EP2290073A3
(en)
*
|
2004-05-28 |
2011-08-31 |
Asuragen, Inc. |
Methods and compositions involving microRNA
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
EP1602926A1
(en)
|
2004-06-04 |
2005-12-07 |
University of Geneva |
Novel means and methods for the treatment of hearing loss and phantom hearing
|
|
CA2569664C
(en)
|
2004-06-07 |
2013-07-16 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
JP4764426B2
(ja)
*
|
2004-06-07 |
2011-09-07 |
プロチバ バイオセラピューティクス インコーポレイティッド |
カチオン性脂質および使用方法
|
|
US20060008907A1
(en)
*
|
2004-06-09 |
2006-01-12 |
The Curators Of The University Of Missouri |
Control of gene expression via light activated RNA interference
|
|
US20090215860A1
(en)
*
|
2004-06-17 |
2009-08-27 |
The Regents Of The University Of California |
Compositions and methods for regulating gene transcription
|
|
WO2006012222A2
(en)
*
|
2004-06-25 |
2006-02-02 |
The J. David Gladstone Institutes |
Methods of treating smooth muscle cell disorders
|
|
EP1789553B1
(en)
|
2004-06-30 |
2014-03-26 |
Alnylam Pharmaceuticals Inc. |
Oligonucleotides comprising a non-phosphate backbone linkage
|
|
EP1773857A4
(en)
*
|
2004-07-02 |
2009-05-13 |
Protiva Biotherapeutics Inc |
THE IMMUNE SYSTEM STIMULATING SIRNA MOLECULES AND APPLICATIONS THEREOF
|
|
EP1765378B1
(en)
|
2004-07-12 |
2014-04-16 |
Medical Research Fund of Tel Aviv Sourasky Medical Center |
Agent capable of downregulating an msf-a-dependent hif-1a and use thereof in cancer treatment
|
|
JP2008522951A
(ja)
*
|
2004-07-19 |
2008-07-03 |
ベイラー・カレツジ・オブ・メデイシン |
サイトカインシグナル伝達調節物質の調節および免疫療法のための応用
|
|
WO2006020231A2
(en)
*
|
2004-07-21 |
2006-02-23 |
Medtronic, Inc. |
Medical devices and methods for reducing localized fibrosis
|
|
US20060030538A1
(en)
*
|
2004-07-21 |
2006-02-09 |
Medtronic, Inc. |
Methods for reducing or preventing localized fibrosis using SiRNA
|
|
WO2006093526A2
(en)
|
2004-07-21 |
2006-09-08 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a modified or non-natural nucleobase
|
|
US20100132058A1
(en)
|
2004-07-23 |
2010-05-27 |
Diatchenko Luda B |
Methods and materials for determining pain sensitivity and predicting and treating related disorders
|
|
AU2005330637B2
(en)
|
2004-08-04 |
2012-09-20 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
|
|
EP1791567B1
(en)
|
2004-08-10 |
2015-07-29 |
Alnylam Pharmaceuticals Inc. |
Chemically modified oligonucleotides
|
|
WO2006020557A2
(en)
*
|
2004-08-10 |
2006-02-23 |
Immusol, Inc. |
Methods of using or identifying agents that inhibit cancer growth
|
|
EP1789592A4
(en)
*
|
2004-08-13 |
2009-12-23 |
Univ Delaware |
METHOD FOR IDENTIFYING AND QUANTIFYING SHORT OR SMALL ARN
|
|
EP2319925B1
(en)
|
2004-08-16 |
2018-07-25 |
Quark Pharmaceuticals, Inc. |
Therapeutic uses of inhibitors of RTP801
|
|
US20070021366A1
(en)
*
|
2004-11-19 |
2007-01-25 |
Srivastava Satish K |
Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
|
|
HUE033977T2
(en)
|
2004-08-23 |
2018-02-28 |
Sylentis Sau |
Treatment of eye disorders with siRNAs characterized by increased intraocular pressure
|
|
US7323310B2
(en)
|
2004-08-31 |
2008-01-29 |
Qiagen North American Holdings, Inc. |
Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase
|
|
MX2007002423A
(es)
*
|
2004-08-31 |
2007-08-07 |
Sylentis Sau |
Metodos y composiciones para inhibir la expresion del receptor p2x7.
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
WO2006031901A2
(en)
|
2004-09-10 |
2006-03-23 |
Somagenics, Inc. |
SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF
|
|
WO2006033965A2
(en)
*
|
2004-09-16 |
2006-03-30 |
The Trustees Of The University Of Pennsylvania |
Nadph oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities
|
|
FI20041204A0
(fi)
|
2004-09-16 |
2004-09-16 |
Riikka Lund |
Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi
|
|
EP2377873B1
(en)
|
2004-09-24 |
2014-08-20 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of ApoB and uses thereof
|
|
AU2005288522B2
(en)
|
2004-09-28 |
2012-06-28 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
|
|
EP1796686A4
(en)
*
|
2004-09-30 |
2008-05-14 |
Centocor Inc |
EMMPRINE ANTAGONISTS AND ITS USES
|
|
NZ582988A
(en)
|
2004-10-21 |
2011-07-29 |
Venganza Inc |
Methods and materials for conferring resistance to pests and pathogens of plants
|
|
US7790878B2
(en)
*
|
2004-10-22 |
2010-09-07 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
|
|
EP1802755A1
(en)
*
|
2004-10-22 |
2007-07-04 |
Neuregenix Limited |
Neuron regeneration
|
|
US20060089324A1
(en)
*
|
2004-10-22 |
2006-04-27 |
Sailen Barik |
RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
|
|
US20060110440A1
(en)
*
|
2004-10-22 |
2006-05-25 |
Kiminobu Sugaya |
Method and system for biasing cellular development
|
|
AR051829A1
(es)
*
|
2004-10-27 |
2007-02-14 |
Schering Corp |
Composiciones y metodos para inhibicion de nav 1 mediante arn corto de interferencia
|
|
WO2006047673A2
(en)
|
2004-10-27 |
2006-05-04 |
Vanderbilt University |
Mammalian genes involved in infection
|
|
CN101048139A
(zh)
*
|
2004-10-28 |
2007-10-03 |
艾德克斯实验室公司 |
药物活性化合物的控释组合物
|
|
US20060094676A1
(en)
*
|
2004-10-29 |
2006-05-04 |
Ronit Lahav |
Compositions and methods for treating cancer using compositions comprising an inhibitor of endothelin receptor activity
|
|
WO2007001448A2
(en)
|
2004-11-04 |
2007-01-04 |
Massachusetts Institute Of Technology |
Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
|
|
EP2302055B1
(en)
|
2004-11-12 |
2014-08-27 |
Asuragen, Inc. |
Methods and compositions involving miRNA and miRNA inhibitor molecules
|
|
US20060105052A1
(en)
*
|
2004-11-15 |
2006-05-18 |
Acar Havva Y |
Cationic nanoparticle having an inorganic core
|
|
US8809287B2
(en)
*
|
2004-11-15 |
2014-08-19 |
Icahn School Of Medicine At Mount Sinai |
Compositions and methods for altering Wnt autocrine signaling
|
|
CA2587411A1
(en)
*
|
2004-11-17 |
2006-05-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of apolipoprotein b
|
|
ES2556272T3
(es)
*
|
2004-11-18 |
2016-01-14 |
The Board Of Trustees Of The University Of Illinois |
Constructos de ARNsi multicistrónico para inhibir tumores
|
|
KR101330229B1
(ko)
*
|
2004-11-19 |
2013-11-15 |
가부시키가이샤 진케어켄큐쇼 |
암세포 특이적 세포증식 억제제
|
|
US20060166234A1
(en)
*
|
2004-11-22 |
2006-07-27 |
Barbara Robertson |
Apparatus and system having dry control gene silencing compositions
|
|
US7923207B2
(en)
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing pools
|
|
US7935811B2
(en)
|
2004-11-22 |
2011-05-03 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing compositions
|
|
CA2587697A1
(en)
*
|
2004-11-24 |
2006-07-13 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of the bcr-abl fusion gene and uses thereof
|
|
JP2008521909A
(ja)
*
|
2004-12-02 |
2008-06-26 |
ビー−ブリッジ インターナショナル,インコーポレーテッド |
短鎖干渉rna、アンチセンスポリヌクレオチド、および他のハイブリッド形成化ポリヌクレオチドの設計方法
|
|
US20060165667A1
(en)
*
|
2004-12-03 |
2006-07-27 |
Case Western Reserve University |
Novel methods, compositions and devices for inducing neovascularization
|
|
EP1824872B1
(en)
*
|
2004-12-14 |
2012-02-08 |
Alnylam Pharmaceuticals Inc. |
Rnai modulation of mll-af4 and uses thereof
|
|
US20090123426A1
(en)
|
2004-12-17 |
2009-05-14 |
Chiang Li |
Compositions for Bacterial Mediated Gene Silencing and Methods of Using the Same
|
|
GB0427916D0
(en)
*
|
2004-12-21 |
2005-01-19 |
Astrazeneca Ab |
Method
|
|
TWI386225B
(zh)
|
2004-12-23 |
2013-02-21 |
Alcon Inc |
用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術
|
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
US20090005332A1
(en)
*
|
2004-12-30 |
2009-01-01 |
Hauser Todd M |
Compositions and Methods for Modulating Gene Expression Using Self-Protected Oligonucleotides
|
|
CA2594040A1
(en)
*
|
2005-01-06 |
2006-07-13 |
The Johns Hopkins University |
Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines
|
|
EP2230517A1
(en)
|
2005-01-07 |
2010-09-22 |
Diadexus, Inc. |
OVR110 antibody compositions and methods of use
|
|
CN102600480B
(zh)
*
|
2005-01-07 |
2015-07-22 |
阿尔尼拉姆医药品有限公司 |
RSV的RNAi调节及其治疗应用
|
|
EP1841464B1
(en)
*
|
2005-01-24 |
2012-06-27 |
Alnylam Pharmaceuticals Inc. |
Rnai modulation of the nogo-l or nogo-r gene and uses thereof
|
|
CA2595726A1
(en)
*
|
2005-01-26 |
2006-08-03 |
The Johns Hopkins University |
Anti-cancer dna vaccine employing plasmids encoding mutant oncoprotein antigen and calreticulin
|
|
TW200639252A
(en)
*
|
2005-02-01 |
2006-11-16 |
Alcon Inc |
RNAi-mediated inhibition of ocular hypertension targets
|
|
WO2006085700A2
(en)
*
|
2005-02-14 |
2006-08-17 |
Hvc Stragetic Research Institute, Inc. |
Pharmaceutical agents for preventing metastasis of cancer
|
|
US7745389B2
(en)
|
2005-02-14 |
2010-06-29 |
University Of Iowa Research Foundation |
Methods for treatment of age-related macular degeneration
|
|
EP2157182A3
(en)
|
2005-03-08 |
2012-04-25 |
Qiagen GmbH |
Modified short interfering RNA
|
|
WO2006099353A1
(en)
|
2005-03-11 |
2006-09-21 |
Alcon, Inc. |
Rnai-mediated inhibition of frizzled related protein-1 for treatment of glaucoma
|
|
US8999943B2
(en)
*
|
2005-03-14 |
2015-04-07 |
Board Of Regents, The University Of Texas System |
Antigene oligomers inhibit transcription
|
|
GB0505081D0
(en)
*
|
2005-03-14 |
2005-04-20 |
Genomica Sau |
Downregulation of interleukin-12 expression by means of rnai technology
|
|
JP4585342B2
(ja)
*
|
2005-03-18 |
2010-11-24 |
株式会社資生堂 |
不全角化を抑制する物質のスクリーニング方法、同方法によりスクリーニングされた物質及び不全角化を抑制する方法
|
|
EP1877556B1
(en)
*
|
2005-03-25 |
2011-09-14 |
Medtronic, Inc. |
Use of anti-tnf or anti-il1 rnai to suppress pro- inflammatory cytokine actions locally to treat pain
|
|
JP2008537551A
(ja)
*
|
2005-03-31 |
2008-09-18 |
カランド ファーマシューティカルズ, インコーポレイテッド |
リボヌクレオチドレダクターゼサブユニット2の阻害剤およびその使用
|
|
WO2006113743A2
(en)
*
|
2005-04-18 |
2006-10-26 |
Massachusetts Institute Of Technology |
Compositions and methods for rna interference with sialidase expression and uses thereof
|
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
|
WO2006121960A2
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
|
WO2007008300A2
(en)
*
|
2005-05-31 |
2007-01-18 |
ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE |
Triblock copolymers for cytoplasmic delivery of gene-based drugs
|
|
US20070048293A1
(en)
*
|
2005-05-31 |
2007-03-01 |
The Trustees Of The University Of Pennsylvania |
Manipulation of PTEN in T cells as a strategy to modulate immune responses
|
|
JP5371424B2
(ja)
|
2005-06-01 |
2013-12-18 |
ポリプラス トランスフェクション エスアー |
Rna干渉のためのオリゴヌクレオチドおよびその生物学的適用
|
|
WO2006130716A2
(en)
*
|
2005-06-01 |
2006-12-07 |
Duke University |
Method of inhibiting intimal hyperplasia
|
|
WO2006131925A2
(en)
*
|
2005-06-10 |
2006-12-14 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
|
|
CN100445381C
(zh)
*
|
2005-06-10 |
2008-12-24 |
中国人民解放军军事医学科学院基础医学研究所 |
带有单链polyA尾巴的siRNA分子制备方法和应用
|
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
US7838503B2
(en)
*
|
2005-06-15 |
2010-11-23 |
Children's Medical Center Corporation |
Methods for extending the replicative lifespan of cells
|
|
FI20050640A0
(fi)
*
|
2005-06-16 |
2005-06-16 |
Faron Pharmaceuticals Oy |
Yhdisteitä amiinioksidaasista riippuvien sairauksien tai häiriöiden hoitoon tai estoon
|
|
US7868159B2
(en)
*
|
2005-06-23 |
2011-01-11 |
Baylor College Of Medicine |
Modulation of negative immune regulators and applications for immunotherapy
|
|
WO2007002718A2
(en)
*
|
2005-06-27 |
2007-01-04 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of hif-1 and theraputic uses thereof
|
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
|
ES2435774T3
(es)
|
2005-07-07 |
2013-12-23 |
Yissum Research Development Company, Of The Hebrew University Of Jerusalem |
Agentes de ácido nucleico para la regulación negativa de H19, y métodos de uso del mismo
|
|
US8703769B2
(en)
|
2005-07-15 |
2014-04-22 |
The University Of North Carolina At Chapel Hill |
Use of EGFR inhibitors to prevent or treat obesity
|
|
EP1910528A2
(de)
*
|
2005-07-25 |
2008-04-16 |
Technische Universität Dresden |
Rna-abhängige rna-polymerase, verfahren und kits zur amplifikation und / oder markierung von rna
|
|
WO2007014370A2
(en)
*
|
2005-07-28 |
2007-02-01 |
University Of Delaware |
Small regulatory rnas and methods of use
|
|
US7919583B2
(en)
|
2005-08-08 |
2011-04-05 |
Discovery Genomics, Inc. |
Integration-site directed vector systems
|
|
US20070213257A1
(en)
*
|
2005-08-12 |
2007-09-13 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for complexes of nucleic acids and peptides
|
|
RU2418068C2
(ru)
*
|
2005-08-17 |
2011-05-10 |
Сирна Терапьютикс, Инк. |
Молекулы химически модифицированной короткой интерферирующей нуклеиновой кислоты, которые опосредуют интерференцию рнк
|
|
EP1937066A4
(en)
|
2005-08-18 |
2008-12-24 |
Alnylam Pharmaceuticals Inc |
METHOD AND COMPOSITIONS FOR THE TREATMENT OF NERVOUS DISEASES
|
|
US20070054873A1
(en)
*
|
2005-08-26 |
2007-03-08 |
Protiva Biotherapeutics, Inc. |
Glucocorticoid modulation of nucleic acid-mediated immune stimulation
|
|
US8501703B2
(en)
|
2005-08-30 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
WO2007030167A1
(en)
*
|
2005-09-02 |
2007-03-15 |
Nastech Pharmaceutical Company Inc. |
Modification of double-stranded ribonucleic acid molecules
|
|
WO2007033058A2
(en)
*
|
2005-09-13 |
2007-03-22 |
Trustees Of Dartmouth College |
Compositions and methods for regulating rna translation via cd154 ca-dinucleotide repeat
|
|
WO2007039454A1
(en)
|
2005-09-20 |
2007-04-12 |
Basf Plant Science Gmbh |
Methods for controlling gene expression using ta-siran
|
|
FR2890859B1
(fr)
*
|
2005-09-21 |
2012-12-21 |
Oreal |
Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase
|
|
US8933043B2
(en)
*
|
2005-09-30 |
2015-01-13 |
St. Jude Children's Research Hospital |
Methods for regulation of p53 translation and function
|
|
US8168584B2
(en)
|
2005-10-08 |
2012-05-01 |
Potentia Pharmaceuticals, Inc. |
Methods of treating age-related macular degeneration by compstatin and analogs thereof
|
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
|
WO2007048046A2
(en)
*
|
2005-10-20 |
2007-04-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of filovirus gene expression
|
|
GB0521351D0
(en)
*
|
2005-10-20 |
2005-11-30 |
Genomica Sau |
Modulation of TRPV expression levels
|
|
GB0521716D0
(en)
*
|
2005-10-25 |
2005-11-30 |
Genomica Sau |
Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
|
|
WO2007049690A1
(ja)
*
|
2005-10-27 |
2007-05-03 |
National University Corporation NARA Institute of Science and Technology |
Singarの発現または機能の抑制による神経軸索の形成・伸長と神経再生への応用
|
|
JP5111385B2
(ja)
|
2005-10-28 |
2013-01-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ハンチンチン遺伝子の発現を抑制するための組成物および方法
|
|
CN101346393B
(zh)
|
2005-11-02 |
2015-07-22 |
普洛体维生物治疗公司 |
修饰的siRNA分子及其应用
|
|
CA2626584A1
(en)
*
|
2005-11-04 |
2007-05-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of nav1.8 gene
|
|
CA2628477A1
(en)
*
|
2005-11-07 |
2007-05-10 |
Bc Cancer Agency |
Inhibition of autophagy genes in cancer chemotherapy
|
|
US20100069461A1
(en)
*
|
2005-11-09 |
2010-03-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor v leiden mutant gene
|
|
WO2007086990A2
(en)
*
|
2005-11-17 |
2007-08-02 |
Board Of Regents, The University Of Texas System |
Modulation of gene expression by oligomers targeted to chromosomal dna
|
|
US8603991B2
(en)
|
2005-11-18 |
2013-12-10 |
Gradalis, Inc. |
Individualized cancer therapy
|
|
US8916530B2
(en)
|
2005-11-18 |
2014-12-23 |
Gradalis, Inc. |
Individualized cancer therapy
|
|
US20080125384A1
(en)
*
|
2005-11-21 |
2008-05-29 |
Shuewi Yang |
Simultaneous silencing and restoration of gene function
|
|
WO2007061022A1
(ja)
*
|
2005-11-24 |
2007-05-31 |
Jichi Medical University |
プロヒビチン2(phb2)のミトコンドリア機能
|
|
WO2007070682A2
(en)
|
2005-12-15 |
2007-06-21 |
Massachusetts Institute Of Technology |
System for screening particles
|
|
AU2006337093B2
(en)
*
|
2005-12-22 |
2013-03-14 |
Opko Pharmaceuticals, Llc. |
Compositions and methods for regulating complement system
|
|
AR057252A1
(es)
*
|
2005-12-27 |
2007-11-21 |
Alcon Mfg Ltd |
Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares
|
|
JP5713377B2
(ja)
|
2005-12-28 |
2015-05-07 |
ザ スクリプス リサーチ インスティテュート |
薬物標的としての天然アンチセンスおよび非コードrna転写物
|
|
US8673873B1
(en)
*
|
2005-12-28 |
2014-03-18 |
Alcon Research, Ltd. |
RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of cAMP-related ocular disorders
|
|
EP1973574B1
(en)
*
|
2005-12-30 |
2014-04-02 |
Institut Gustave Roussy |
Use of inhibitors of scinderin and/or of ephrin-a1 for treating tumors
|
|
US20090060921A1
(en)
*
|
2006-01-17 |
2009-03-05 |
Biolex Therapeutics, Inc. |
Glycan-optimized anti-cd20 antibodies
|
|
JP2009526520A
(ja)
|
2006-01-17 |
2009-07-23 |
バイオレックス セラピュティックス インク |
植物中でのn−グリカンのヒト化及び最適化のための組成物及び方法
|
|
NL2000439C2
(nl)
|
2006-01-20 |
2009-03-16 |
Quark Biotech |
Therapeutische toepassingen van inhibitoren van RTP801.
|
|
US20120208824A1
(en)
|
2006-01-20 |
2012-08-16 |
Cell Signaling Technology, Inc. |
ROS Kinase in Lung Cancer
|
|
US7825099B2
(en)
|
2006-01-20 |
2010-11-02 |
Quark Pharmaceuticals, Inc. |
Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
|
|
WO2007084631A2
(en)
|
2006-01-20 |
2007-07-26 |
Cell Signaling Technology, Inc. |
Translocation and mutant ros kinase in human non-small cell lung carcinoma
|
|
US20070259827A1
(en)
*
|
2006-01-25 |
2007-11-08 |
University Of Massachusetts |
Compositions and methods for enhancing discriminatory RNA interference
|
|
WO2007085485A2
(en)
*
|
2006-01-27 |
2007-08-02 |
Santaris Pharma A/S |
Lna modified phosphorothiolated oligonucleotides
|
|
US8229398B2
(en)
*
|
2006-01-30 |
2012-07-24 |
Qualcomm Incorporated |
GSM authentication in a CDMA network
|
|
EP1989307B1
(en)
*
|
2006-02-08 |
2012-08-08 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
|
US7910566B2
(en)
|
2006-03-09 |
2011-03-22 |
Quark Pharmaceuticals Inc. |
Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
|
|
FI20060246A0
(fi)
*
|
2006-03-16 |
2006-03-16 |
Jukka Westermarck |
Uusi kasvua stimuloiva proteiini ja sen käyttö
|
|
WO2007109609A2
(en)
*
|
2006-03-17 |
2007-09-27 |
The Board Of Trustees Of The University Of Illinois |
Method for inhibiting angiogenesis
|
|
WO2007107162A2
(en)
|
2006-03-23 |
2007-09-27 |
Santaris Pharma A/S |
Small internally segmented interfering rna
|
|
KR20080106554A
(ko)
*
|
2006-03-24 |
2008-12-08 |
노파르티스 아게 |
Hpv 감염을 치료하기 위한 dsrna 조성물 및 방법
|
|
FR2898908A1
(fr)
|
2006-03-24 |
2007-09-28 |
Agronomique Inst Nat Rech |
Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence
|
|
WO2007115047A2
(en)
*
|
2006-03-29 |
2007-10-11 |
Senesco Technologies, Inc. |
Inhibition of hiv replication and expression of p24 with eif-5a
|
|
CA2648099C
(en)
|
2006-03-31 |
2012-05-29 |
The Brigham And Women's Hospital, Inc |
System for targeted delivery of therapeutic agents
|
|
NZ571568A
(en)
|
2006-03-31 |
2010-11-26 |
Alnylam Pharmaceuticals Inc |
Double-stranded RNA molecule compositions and methods for inhibiting expression of Eg5 gene
|
|
US20090226446A1
(en)
*
|
2006-04-06 |
2009-09-10 |
Deutsches Krebsforschungszentrum Stiftung Des Offentilchen Rechts |
Method to Inhibit the Propagation of an Undesired Cell Population
|
|
WO2007117657A2
(en)
|
2006-04-07 |
2007-10-18 |
The Research Foundation Of State University Of New York |
Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
|
|
CA2648581A1
(en)
*
|
2006-04-07 |
2008-09-12 |
Chimeros, Inc. |
Compositions and methods for treating b- cell malignancies
|
|
US9044461B2
(en)
|
2006-04-07 |
2015-06-02 |
The Research Foundation Of State University Of New York |
Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
|
|
US8076306B2
(en)
*
|
2006-04-12 |
2011-12-13 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to hepcidin
|
|
US20100055116A1
(en)
*
|
2006-04-13 |
2010-03-04 |
Liou Hsiou-Chi |
Methods and Compositions for Targeting c-Rel
|
|
PT2450437T
(pt)
|
2006-04-14 |
2017-08-25 |
Cell Signaling Technology Inc |
Defeitos de genes e cinase alk mutante em tumores sólidos humanos
|
|
AU2007238608A1
(en)
|
2006-04-14 |
2007-10-25 |
Massachusetts Institute Of Technology |
Identifying and modulating molecular pathways that mediate nervous system plasticity
|
|
WO2007127919A2
(en)
|
2006-04-28 |
2007-11-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the jc virus
|
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
|
CN101484588B
(zh)
|
2006-05-11 |
2013-11-06 |
阿尔尼拉姆医药品有限公司 |
抑制pcsk9基因表达的组合物和方法
|
|
US20090130212A1
(en)
*
|
2006-05-15 |
2009-05-21 |
Physical Pharmaceutica, Llc |
Composition and improved method for preparation of small particles
|
|
JP5630998B2
(ja)
|
2006-05-15 |
2014-11-26 |
マサチューセッツ インスティテュート オブ テクノロジー |
機能的粒子のためのポリマー
|
|
US20070269892A1
(en)
*
|
2006-05-18 |
2007-11-22 |
Nastech Pharmaceutical Company Inc. |
FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA
|
|
CN101489566B
(zh)
*
|
2006-05-19 |
2012-04-18 |
阿尔尼拉姆医药品有限公司 |
Aha基因的RNAi调控及其治疗性应用
|
|
KR20090019790A
(ko)
*
|
2006-05-19 |
2009-02-25 |
더 스크립스 리서치 인스티튜트 |
단백질 미스폴딩의 치료
|
|
WO2007137220A2
(en)
*
|
2006-05-22 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
|
US9273356B2
(en)
|
2006-05-24 |
2016-03-01 |
Medtronic, Inc. |
Methods and kits for linking polymorphic sequences to expanded repeat mutations
|
|
US20070275923A1
(en)
*
|
2006-05-25 |
2007-11-29 |
Nastech Pharmaceutical Company Inc. |
CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY
|
|
US8598333B2
(en)
*
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
|
GB0610542D0
(en)
*
|
2006-05-26 |
2006-07-05 |
Medical Res Council |
Screening method
|
|
WO2007141796A2
(en)
|
2006-06-09 |
2007-12-13 |
Quark Pharmaceuticals, Inc. |
Therapeutic uses of inhibitors of rtp801l
|
|
US7915399B2
(en)
|
2006-06-09 |
2011-03-29 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
|
DK2029746T3
(da)
*
|
2006-06-12 |
2012-10-08 |
Exegenics Inc D B A Opko Health Inc |
Sammensætninger og fremgangsmåder til siRNA-hæmning af angiogenese
|
|
WO2007147067A2
(en)
*
|
2006-06-14 |
2007-12-21 |
Rosetta Inpharmatics Llc |
Methods and compositions for regulating cell cycle progression
|
|
WO2007150030A2
(en)
|
2006-06-23 |
2007-12-27 |
Massachusetts Institute Of Technology |
Microfluidic synthesis of organic nanoparticles
|
|
WO2008008719A2
(en)
*
|
2006-07-10 |
2008-01-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the myc gene
|
|
GB0613753D0
(en)
*
|
2006-07-11 |
2006-08-23 |
Norwegian Radium Hospital Res |
Method
|
|
EP2479284B1
(en)
|
2006-07-13 |
2017-09-20 |
University of Iowa Research Foundation |
Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration
|
|
JP4756271B2
(ja)
*
|
2006-07-18 |
2011-08-24 |
独立行政法人産業技術総合研究所 |
ガン細胞の老化、アポトーシス誘導剤
|
|
KR101670085B1
(ko)
*
|
2006-07-21 |
2016-10-28 |
사일런스 테라퓨틱스 게엠베하 |
단백질 키나아제 3의 발현을 억제하기 위한 수단
|
|
US20080039415A1
(en)
*
|
2006-08-11 |
2008-02-14 |
Gregory Robert Stewart |
Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
|
|
US20100330105A1
(en)
*
|
2006-08-22 |
2010-12-30 |
John Hopkins University |
Anticancer Combination Therapies
|
|
DE102006039479A1
(de)
|
2006-08-23 |
2008-03-06 |
Febit Biotech Gmbh |
Programmierbare Oligonukleotidsynthese
|
|
US7872118B2
(en)
*
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
|
WO2008036776A2
(en)
*
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
|
|
AU2007299804A1
(en)
*
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
MiR-200 regulated genes and pathways as targets for therapeutic intervention
|
|
EP2066687A4
(en)
|
2006-09-21 |
2010-12-08 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF HAMP GENE
|
|
AU2007299705B2
(en)
|
2006-09-22 |
2012-09-06 |
Dharmacon, Inc. |
Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
|
|
JP2010505897A
(ja)
*
|
2006-10-11 |
2010-02-25 |
マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ |
インフルエンザターゲット
|
|
WO2008063760A2
(en)
*
|
2006-10-18 |
2008-05-29 |
The University Of Texas M.D. Anderson Cancer Center |
Methods for treating cancer targeting transglutaminase
|
|
JP2010507387A
(ja)
*
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のsiRNAおよびその使用方法
|
|
WO2008052774A2
(en)
|
2006-10-31 |
2008-05-08 |
Noxxon Pharma Ag |
Methods for detection of a single- or double-stranded nucleic acid molecule
|
|
ATE508191T1
(de)
|
2006-11-01 |
2011-05-15 |
Medical Res And Infrastructure Fund Of The Tel Aviv Sourasky Medical Ct |
Adipozytenspezifische konstrukte und verfahren zur hemmung der expression von blutplättchen-typ- 12-lipoxygenase
|
|
US8324367B2
(en)
|
2006-11-03 |
2012-12-04 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
|
US9375440B2
(en)
|
2006-11-03 |
2016-06-28 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
|
US8252526B2
(en)
|
2006-11-09 |
2012-08-28 |
Gradalis, Inc. |
ShRNA molecules and methods of use thereof
|
|
US8906874B2
(en)
|
2006-11-09 |
2014-12-09 |
Gradalis, Inc. |
Bi-functional shRNA targeting Stathmin 1 and uses thereof
|
|
US8758998B2
(en)
|
2006-11-09 |
2014-06-24 |
Gradalis, Inc. |
Construction of bifunctional short hairpin RNA
|
|
US7988668B2
(en)
|
2006-11-21 |
2011-08-02 |
Medtronic, Inc. |
Microsyringe for pre-packaged delivery of pharmaceuticals
|
|
US8034921B2
(en)
*
|
2006-11-21 |
2011-10-11 |
Alnylam Pharmaceuticals, Inc. |
IRNA agents targeting CCR5 expressing cells and uses thereof
|
|
US7819842B2
(en)
|
2006-11-21 |
2010-10-26 |
Medtronic, Inc. |
Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
|
|
WO2008062909A1
(en)
*
|
2006-11-22 |
2008-05-29 |
The University Of Tokyo |
ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-BRIDGED POLYMERIC MICELLE
|
|
EP2101813B1
(en)
|
2006-11-27 |
2014-04-02 |
Patrys Limited |
Novel glycosylated peptide target in neoplastic cells
|
|
JP5391073B2
(ja)
|
2006-11-27 |
2014-01-15 |
ディアデクサス インコーポレーテッド |
Ovr110抗体組成物および使用方法
|
|
US20080171719A1
(en)
*
|
2006-11-28 |
2008-07-17 |
Alcon Manufacturing, Ltd. |
RNAi-MEDIATED INHIBITION OF AQUAPORIN 1 FOR TREATMENT OF IOP-RELATED CONDITIONS
|
|
US20090048195A1
(en)
*
|
2006-11-30 |
2009-02-19 |
University Of Southern California |
Compositions and methods of sphingosine kinase inhibitors for use thereof in cancer therapy
|
|
AU2007333107A1
(en)
*
|
2006-12-08 |
2008-06-19 |
Asuragen, Inc. |
miR-21 regulated genes and pathways as targets for therapeutic intervention
|
|
AU2007333109A1
(en)
*
|
2006-12-08 |
2008-06-19 |
Asuragen, Inc. |
Functions and targets of let-7 micro RNAs
|
|
MX2009006310A
(es)
*
|
2006-12-14 |
2009-07-22 |
Novartis Ag |
Composiciones y metodos para tratar trastornos musculares y cardiovasculares.
|
|
CA2671270A1
(en)
*
|
2006-12-29 |
2008-07-17 |
Asuragen, Inc. |
Mir-16 regulated genes and pathways as targets for therapeutic intervention
|
|
US7754698B2
(en)
*
|
2007-01-09 |
2010-07-13 |
Isis Pharmaceuticals, Inc. |
Modulation of FR-alpha expression
|
|
US9896511B2
(en)
|
2007-01-10 |
2018-02-20 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
|
WO2008087641A2
(en)
*
|
2007-01-16 |
2008-07-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
H19 silencing nucleic acid agents for treating rheumatoid arthritis
|
|
US20080171906A1
(en)
*
|
2007-01-16 |
2008-07-17 |
Everaerts Frank J L |
Tissue performance via hydrolysis and cross-linking
|
|
CA2712056C
(en)
|
2007-01-16 |
2016-06-21 |
The University Of Queensland |
Method of inducing an immune response
|
|
WO2008088836A2
(en)
*
|
2007-01-16 |
2008-07-24 |
The Burnham Institute For Medical Research |
Compositions and methods for treatment of colorectal cancer
|
|
WO2008087558A2
(en)
*
|
2007-01-17 |
2008-07-24 |
Institut De Recherches Cliniques De Montreal |
Nucleoside and nucleotide analogues with quaternary carbon centers and methods of use
|
|
CN101641010A
(zh)
|
2007-01-26 |
2010-02-03 |
路易斯维尔大学研究基金会公司 |
用作疫苗的外来体组分的修饰
|
|
US20100196403A1
(en)
*
|
2007-01-29 |
2010-08-05 |
Jacob Hochman |
Antibody conjugates for circumventing multi-drug resistance
|
|
WO2008094860A2
(en)
*
|
2007-01-30 |
2008-08-07 |
Allergan, Inc. |
Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists
|
|
EP2121987B1
(en)
|
2007-02-09 |
2012-06-13 |
Northwestern University |
Particles for detecting intracellular targets
|
|
EP2134830A2
(en)
|
2007-02-09 |
2009-12-23 |
Massachusetts Institute of Technology |
Oscillating cell culture bioreactor
|
|
DE102007008596B4
(de)
|
2007-02-15 |
2010-09-02 |
Friedrich-Schiller-Universität Jena |
Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
|
|
EP2115141A4
(en)
|
2007-02-20 |
2010-08-04 |
Monsanto Technology Llc |
miRNA FROM INVERTEBRATES
|
|
US7872119B2
(en)
|
2007-02-26 |
2011-01-18 |
Quark Pharmaceuticals, Inc. |
Inhibitors of RTP801 and their use in disease treatment
|
|
US20100292301A1
(en)
*
|
2007-02-28 |
2010-11-18 |
Elena Feinstein |
Novel sirna structures
|
|
US20080299659A1
(en)
*
|
2007-03-02 |
2008-12-04 |
Nastech Pharmaceutical Company Inc. |
Nucleic acid compounds for inhibiting apob gene expression and uses thereof
|
|
JP2010519913A
(ja)
*
|
2007-03-02 |
2010-06-10 |
エムディーアールエヌエー,インコーポレイテッド |
Wnt遺伝子の発現を抑制するための核酸化合物およびその使用
|
|
US9018163B2
(en)
*
|
2007-03-02 |
2015-04-28 |
The Trustees Of The University Of Pennsylvania |
Modulating PDX-1 with PCIF1, methods and uses thereof
|
|
US9085638B2
(en)
|
2007-03-07 |
2015-07-21 |
The Johns Hopkins University |
DNA vaccine enhancement with MHC class II activators
|
|
US20080260765A1
(en)
*
|
2007-03-15 |
2008-10-23 |
Johns Hopkins University |
HPV DNA Vaccines and Methods of Use Thereof
|
|
EP2129680B1
(en)
|
2007-03-21 |
2015-05-06 |
Brookhaven Science Associates, LLC |
Combined hairpin-antisense compositions and methods for modulating expression
|
|
US7812002B2
(en)
|
2007-03-21 |
2010-10-12 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer
|
|
PE20090064A1
(es)
*
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
|
|
EP2905336A1
(en)
|
2007-03-29 |
2015-08-12 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inhibiting expression of a gene from the ebola
|
|
JP2010523595A
(ja)
*
|
2007-04-04 |
2010-07-15 |
マサチューセッツ インスティテュート オブ テクノロジー |
ポリ(アミノ酸)ターゲッティング部分
|
|
WO2008124634A1
(en)
|
2007-04-04 |
2008-10-16 |
Massachusetts Institute Of Technology |
Polymer-encapsulated reverse micelles
|
|
CA2683063A1
(en)
*
|
2007-04-09 |
2008-10-16 |
Chimeros, Inc. |
Self-assembling nanoparticle drug delivery system
|
|
CA2678055C
(en)
|
2007-04-10 |
2016-02-16 |
Qiagen Gmbh |
Rna interference tags
|
|
CN101686939B
(zh)
*
|
2007-04-17 |
2013-03-27 |
巴克斯特国际公司 |
用于肺部投送的核酸微粒
|
|
CA2685127C
(en)
|
2007-04-23 |
2019-01-08 |
Alnylam Pharmaceuticals, Inc. |
Glycoconjugates of rna interference agents
|
|
WO2008143774A2
(en)
*
|
2007-05-01 |
2008-11-27 |
University Of Massachusetts |
Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy
|
|
EP2607477B1
(en)
|
2007-05-03 |
2020-09-23 |
The Brigham and Women's Hospital, Inc. |
Multipotent stem cells and uses thereof
|
|
JP5296328B2
(ja)
*
|
2007-05-09 |
2013-09-25 |
独立行政法人理化学研究所 |
1本鎖環状rnaおよびその製造方法
|
|
CA2684920A1
(en)
*
|
2007-05-15 |
2008-11-27 |
Helicon Therapeutics, Inc. |
Methods of treating cognitive disorders by inhibition of gpr12
|
|
BRPI0811623A2
(pt)
*
|
2007-05-15 |
2014-11-11 |
Helicon Therapeutics Inc |
Métodos para identificar genes envolvidos na formação de memória usando pequeno rna interferente (sirna)
|
|
KR101629017B1
(ko)
|
2007-05-22 |
2016-06-10 |
아크투루스 쎄라퓨틱스, 인크. |
히드록시메틸 치환된 rna 올리고뉴클레오티드 및 rna 복합체
|
|
US20090131354A1
(en)
*
|
2007-05-22 |
2009-05-21 |
Bader Andreas G |
miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
|
|
EP2160464B1
(en)
|
2007-05-30 |
2014-05-21 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
EP2581081A3
(en)
|
2007-06-01 |
2013-07-31 |
The Trustees Of Princeton University |
Treatment of viral infections by modulation of host cell metabolic pathways
|
|
KR101363928B1
(ko)
*
|
2007-06-11 |
2014-02-19 |
고쿠리츠다이가쿠호진 미에다이가쿠 |
특이적 유전자 발현 방법
|
|
AR066984A1
(es)
*
|
2007-06-15 |
2009-09-23 |
Novartis Ag |
Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
|
|
WO2008152636A2
(en)
*
|
2007-06-15 |
2008-12-18 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for inhibiting nadph oxidase expression
|
|
WO2009001359A2
(en)
|
2007-06-27 |
2008-12-31 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of pro-apoptotic genes
|
|
EP3711755A1
(en)
|
2007-06-29 |
2020-09-23 |
Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. |
Method of fixing and expressing physiologically active substance
|
|
EP2316943B1
(en)
*
|
2007-07-05 |
2013-06-19 |
Novartis AG |
DSRNA for treating viral infection
|
|
JP2010532989A
(ja)
*
|
2007-07-10 |
2010-10-21 |
ニューリム ファーマシューティカルズ (1991) リミテッド |
神経変性疾患におけるcd44スプライスバリアント
|
|
US8828960B2
(en)
*
|
2007-07-17 |
2014-09-09 |
Idexx Laboratories, Inc. |
Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
|
|
JP2009033986A
(ja)
*
|
2007-07-31 |
2009-02-19 |
Sumitomo Chemical Co Ltd |
RNA干渉による遺伝子発現抑制のためのターゲット遺伝子としてのcar遺伝子の使用
|
|
EP2030615A3
(en)
|
2007-08-13 |
2009-12-02 |
ELFORD, Howard L. |
Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases
|
|
US8501929B2
(en)
*
|
2007-08-17 |
2013-08-06 |
Biochrom Pharma Inc. |
PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
|
|
EP3889261A1
(en)
*
|
2007-08-27 |
2021-10-06 |
1Globe Health Institute LLC |
Compositions of asymmetric interfering rna and uses thereof
|
|
CA2747020A1
(en)
*
|
2007-08-30 |
2009-03-05 |
Virexx Medical Corp. |
Antigenic compositions and use of same in the targeted delivery of nucleic acids
|
|
US20090081789A1
(en)
*
|
2007-08-31 |
2009-03-26 |
Greenville Hospital System |
Activation of nuclear factor kappa B
|
|
WO2009033027A2
(en)
|
2007-09-05 |
2009-03-12 |
Medtronic, Inc. |
Suppression of scn9a gene expression and/or function for the treatment of pain
|
|
CN101970012A
(zh)
*
|
2007-09-14 |
2011-02-09 |
日东电工株式会社 |
药物载体
|
|
WO2009036332A1
(en)
|
2007-09-14 |
2009-03-19 |
Asuragen, Inc. |
Micrornas differentially expressed in cervical cancer and uses thereof
|
|
JP5049713B2
(ja)
*
|
2007-09-14 |
2012-10-17 |
株式会社コナミデジタルエンタテインメント |
ゲームシステム並びにこれを構成するゲーム装置及び課題報知装置
|
|
EP2195428B1
(en)
|
2007-09-19 |
2013-12-11 |
Applied Biosystems, LLC |
SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF
|
|
WO2009042625A1
(en)
*
|
2007-09-25 |
2009-04-02 |
Idexx Laboratories, Inc. |
Pharmaceutical compositions for administering oligonucleotides
|
|
EP2436376B1
(en)
|
2007-09-28 |
2014-07-09 |
BIND Therapeutics, Inc. |
Cancer cell targeting using nanoparticles
|
|
US20120082659A1
(en)
*
|
2007-10-02 |
2012-04-05 |
Hartmut Land |
Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
|
|
RU2487716C2
(ru)
|
2007-10-03 |
2013-07-20 |
Кварк Фармасьютикалс, Инк. |
Новые структуры малых интерферирующих рнк (sirna)
|
|
AU2008308499A1
(en)
*
|
2007-10-04 |
2009-04-09 |
Board Of Regents, The University Of Texas System |
Modulating gene expression with agRNA and gapmers targeting antisense transcripts
|
|
JP2011500569A
(ja)
|
2007-10-12 |
2011-01-06 |
マサチューセッツ インスティテュート オブ テクノロジー |
ワクチンナノテクノロジー
|
|
JP5769968B2
(ja)
|
2007-10-18 |
2015-08-26 |
セル・シグナリング・テクノロジー・インコーポレイテツド |
ヒト非小細胞肺癌における転座および変異rosキナーゼ
|
|
US8097712B2
(en)
*
|
2007-11-07 |
2012-01-17 |
Beelogics Inc. |
Compositions for conferring tolerance to viral disease in social insects, and the use thereof
|
|
US20100098664A1
(en)
*
|
2007-11-28 |
2010-04-22 |
Mathieu Jean-Francois Desclaux |
Lentiviral vectors allowing RNAi mediated inhibition of GFAP and vimentin expression
|
|
JP2011505144A
(ja)
*
|
2007-11-30 |
2011-02-24 |
ベイラー カレッジ オブ メディシン |
樹状細胞ワクチン組成物およびその使用
|
|
WO2009070805A2
(en)
*
|
2007-12-01 |
2009-06-04 |
Asuragen, Inc. |
Mir-124 regulated genes and pathways as targets for therapeutic intervention
|
|
WO2010070380A2
(en)
|
2007-12-03 |
2010-06-24 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health |
Doc1 compositions and methods for treating cancer
|
|
WO2009073809A2
(en)
|
2007-12-04 |
2009-06-11 |
Alnylam Pharmaceuticals, Inc. |
Carbohydrate conjugates as delivery agents for oligonucleotides
|
|
WO2009082606A2
(en)
*
|
2007-12-04 |
2009-07-02 |
Alnylam Pharmaceuticals, Inc. |
Folate conjugates
|
|
CA2707042A1
(en)
|
2007-12-10 |
2009-06-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor vii gene
|
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
|
US20110105584A1
(en)
*
|
2007-12-12 |
2011-05-05 |
Elena Feinstein |
Rtp80il sirna compounds and methods of use thereof
|
|
NZ585784A
(en)
|
2007-12-13 |
2012-09-28 |
Alnylam Pharmaceuticals Inc |
siRNAs for the treatment and prevention of respiratory syncytial virus (RSV) infection
|
|
US20090176729A1
(en)
*
|
2007-12-14 |
2009-07-09 |
Alnylam Pharmaceuticals, Inc. |
Method of treating neurodegenerative disease
|
|
US7845686B2
(en)
*
|
2007-12-17 |
2010-12-07 |
S & B Technical Products, Inc. |
Restrained pipe joining system for plastic pipe
|
|
KR100949791B1
(ko)
*
|
2007-12-18 |
2010-03-30 |
이동기 |
오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도
|
|
WO2009086156A2
(en)
*
|
2007-12-21 |
2009-07-09 |
Asuragen, Inc. |
Mir-10 regulated genes and pathways as targets for therapeutic intervention
|
|
EP2242854A4
(en)
*
|
2008-01-15 |
2012-08-15 |
Quark Pharmaceuticals Inc |
COMPOUNDS AND USES THEREOF
|
|
CA2713379A1
(en)
*
|
2008-01-31 |
2009-11-05 |
Alnylam Pharmaceuticals, Inc. |
Optimized methods for delivery of dsrna targeting the pcsk9 gene
|
|
EP2260110B1
(en)
*
|
2008-02-08 |
2014-11-12 |
Asuragen, INC. |
miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
|
|
CA2715289C
(en)
|
2008-02-11 |
2019-12-24 |
Rxi Pharmaceuticals Corporation |
Modified rnai polynucleotides and uses thereof
|
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
|
US7977321B2
(en)
*
|
2008-02-12 |
2011-07-12 |
University Of Tennessee Research Foundation |
Small interfering RNAs targeting feline herpes virus
|
|
US8288525B2
(en)
*
|
2008-02-12 |
2012-10-16 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of CD45 gene
|
|
JP2011515072A
(ja)
*
|
2008-02-13 |
2011-05-19 |
エラン ファーマ インターナショナル リミテッド |
α−シヌクレインキナーゼ
|
|
DE102009043743B4
(de)
|
2009-03-13 |
2016-10-13 |
Friedrich-Schiller-Universität Jena |
Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
|
|
WO2009103067A2
(en)
*
|
2008-02-14 |
2009-08-20 |
The Children's Hospital Of Philadelphia |
Compositions and methods to treat asthma
|
|
KR101397407B1
(ko)
|
2008-03-05 |
2014-06-19 |
알닐람 파마슈티칼스 인코포레이티드 |
Eg5 및 VEGF 유전자의 발현을 억제하기 위한 조성물 및 방법
|
|
WO2009111643A2
(en)
*
|
2008-03-06 |
2009-09-11 |
Asuragen, Inc. |
Microrna markers for recurrence of colorectal cancer
|
|
EP2265291B1
(en)
*
|
2008-03-17 |
2016-10-19 |
The Board of Regents of The University of Texas System |
Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration
|
|
CA2718765A1
(en)
*
|
2008-03-20 |
2009-09-24 |
Quark Pharmaceuticals, Inc. |
Novel sirna compounds for inhibiting rtp801
|
|
EP2271757A2
(en)
*
|
2008-03-26 |
2011-01-12 |
Asuragen, INC. |
Compositions and methods related to mir-16 and therapy of prostate cancer
|
|
EP2105145A1
(en)
*
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Method for muscle-specific delivery lipid-conjugated oligonucleotides
|
|
EP2264167B1
(en)
*
|
2008-03-31 |
2016-10-12 |
National Institute of Advanced Industrial Science and Technology |
Double-stranded lipid-modified rna having high rna interference effect
|
|
TWI348916B
(en)
*
|
2008-04-03 |
2011-09-21 |
Univ Nat Taiwan |
A novel treatment tool for cancer: rna interference of bcas2
|
|
WO2009126726A1
(en)
*
|
2008-04-08 |
2009-10-15 |
Asuragen, Inc |
Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
|
|
WO2009126913A1
(en)
|
2008-04-11 |
2009-10-15 |
Cedars-Sinai Medical Center |
Poly(beta malic acid) with pendant leu-leu-leu tripeptide for effective cytoplasmic drug delivery
|
|
CA2721183C
(en)
|
2008-04-11 |
2019-07-16 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
EP2285385A4
(en)
*
|
2008-04-15 |
2013-01-16 |
Quark Pharmaceuticals Inc |
COMPOUNDS BASED ON RNSI TO INHIBIT NRF2
|
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
|
US20090285861A1
(en)
*
|
2008-04-17 |
2009-11-19 |
Tzyy-Choou Wu |
Tumor cell-based cancer immunotherapeutic compositions and methods
|
|
US7875711B2
(en)
*
|
2008-04-17 |
2011-01-25 |
Alnylam Pharamaceuticals, Inc. |
Compositions and methods for inhibiting expression of XBP-1 gene
|
|
USRE48948E1
(en)
|
2008-04-18 |
2022-03-01 |
Warsaw Orthopedic, Inc. |
Clonidine compounds in a biodegradable polymer
|
|
BRPI0910686A2
(pt)
|
2008-04-21 |
2015-09-29 |
Tissue Regeneration Therapeutics Inc |
células perivasculares do cordão umbilical humano geneticamente modificadas para a profilaxia contra agentes biológicos e químicos ou para o tratamento dos mesmos.
|
|
US8324366B2
(en)
|
2008-04-29 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for delivering RNAI using lipoproteins
|
|
US8173616B2
(en)
*
|
2008-05-02 |
2012-05-08 |
The Brigham And Women's Hospital, Inc. |
RNA-induced translational silencing and cellular apoptosis
|
|
WO2009137807A2
(en)
|
2008-05-08 |
2009-11-12 |
Asuragen, Inc. |
Compositions and methods related to mirna modulation of neovascularization or angiogenesis
|
|
US20090291073A1
(en)
*
|
2008-05-20 |
2009-11-26 |
Ward Keith W |
Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same
|
|
US20100009451A1
(en)
*
|
2008-05-30 |
2010-01-14 |
Sigma Aldrich Company |
Compositions and methods for specifically silencing a target nucleic acid
|
|
US8222221B2
(en)
|
2008-06-04 |
2012-07-17 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small RNA targeting of gene promoters
|
|
US20090305611A1
(en)
*
|
2008-06-06 |
2009-12-10 |
Flow International Corporation |
Device and method for improving accuracy of a high-pressure fluid jet apparatus
|
|
WO2009147684A2
(en)
|
2008-06-06 |
2009-12-10 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treatment of ear disorders
|
|
US20110053226A1
(en)
*
|
2008-06-13 |
2011-03-03 |
Riboxx Gmbh |
Method for enzymatic synthesis of chemically modified rna
|
|
WO2010005741A1
(en)
*
|
2008-06-16 |
2010-01-14 |
Georgia Tech Research Corporation |
Nanogels for cellular delivery of therapeutics
|
|
TWI455944B
(zh)
|
2008-07-01 |
2014-10-11 |
Daiichi Sankyo Co Ltd |
雙股多核苷酸
|
|
US20110184046A1
(en)
|
2008-07-11 |
2011-07-28 |
Dinah Wen-Yee Sah |
Compositions And Methods For Inhibiting Expression Of GSK-3 Genes
|
|
WO2010008562A2
(en)
|
2008-07-16 |
2010-01-21 |
Recombinetics |
Methods and materials for producing transgenic animals
|
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
|
US8039658B2
(en)
*
|
2008-07-25 |
2011-10-18 |
Air Products And Chemicals, Inc. |
Removal of trace arsenic impurities from triethylphosphate (TEPO)
|
|
US8212019B2
(en)
*
|
2008-07-30 |
2012-07-03 |
University Of Massachusetts |
Nucleic acid silencing sequences
|
|
WO2010021720A1
(en)
|
2008-08-19 |
2010-02-25 |
Nektar Therapeutics |
Conjugates of small-interfering nucleic acids
|
|
NZ601660A
(en)
|
2008-08-25 |
2014-05-30 |
Excaliard Pharmaceuticals Inc |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
|
WO2011028218A1
(en)
|
2009-09-02 |
2011-03-10 |
Alnylam Pharmaceuticals, Inc. |
Process for triphosphate oligonucleotide synthesis
|
|
US8383604B2
(en)
|
2008-09-15 |
2013-02-26 |
Children's Medical Center Corporation |
Modulation of BCL11A for treatment of hemoglobinopathies
|
|
EP2342340A1
(en)
|
2008-09-22 |
2011-07-13 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
|
AU2009298802A1
(en)
|
2008-09-23 |
2010-04-08 |
Alnylam Pharmaceuticals, Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
|
AU2009296395A1
(en)
|
2008-09-25 |
2010-04-01 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Serum Amyloid A gene
|
|
EP2344638A1
(en)
|
2008-10-06 |
2011-07-20 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of an rna from west nile virus
|
|
US9388413B2
(en)
|
2008-10-08 |
2016-07-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
|
US8802646B2
(en)
*
|
2008-10-08 |
2014-08-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease
|
|
WO2010042292A1
(en)
*
|
2008-10-08 |
2010-04-15 |
Trustees Of Dartmouth College |
Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease
|
|
US9149492B2
(en)
|
2008-10-08 |
2015-10-06 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
|
|
US9388414B2
(en)
|
2008-10-08 |
2016-07-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
|
CA2740000C
(en)
|
2008-10-09 |
2017-12-12 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
US8591905B2
(en)
|
2008-10-12 |
2013-11-26 |
The Brigham And Women's Hospital, Inc. |
Nicotine immunonanotherapeutics
|
|
US8343498B2
(en)
|
2008-10-12 |
2013-01-01 |
Massachusetts Institute Of Technology |
Adjuvant incorporation in immunonanotherapeutics
|
|
US8343497B2
(en)
|
2008-10-12 |
2013-01-01 |
The Brigham And Women's Hospital, Inc. |
Targeting of antigen presenting cells with immunonanotherapeutics
|
|
US8277812B2
(en)
|
2008-10-12 |
2012-10-02 |
Massachusetts Institute Of Technology |
Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
|
|
US9458472B2
(en)
*
|
2008-10-15 |
2016-10-04 |
Massachusetts Institute Of Technology |
Detection and destruction of cancer cells using programmed genetic vectors
|
|
JP2012505657A
(ja)
|
2008-10-15 |
2012-03-08 |
ソマジェニックス インク. |
遺伝子発現の阻害のためのショートヘアピンrna
|
|
MX360460B
(es)
|
2008-10-20 |
2018-11-05 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para inhibir la expresion de transtiretina.
|
|
WO2010046889A1
(en)
*
|
2008-10-23 |
2010-04-29 |
Quark Pharmaceuticals, Inc. |
Methods for delivery of sirna to bone marrow cells and uses thereof
|
|
EP2350277A1
(en)
*
|
2008-10-23 |
2011-08-03 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules
|
|
CN111808084A
(zh)
|
2008-11-10 |
2020-10-23 |
阿布特斯生物制药公司 |
用于递送治疗剂的新型脂质和组合物
|
|
WO2010056737A2
(en)
*
|
2008-11-11 |
2010-05-20 |
Mirna Therapeutics, Inc. |
Methods and compositions involving mirnas in cancer stem cells
|
|
AU2009313851A1
(en)
*
|
2008-11-13 |
2010-05-20 |
Modgene, Llc |
Modification of amyloid-beta load in non-brain tissue
|
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
|
WO2010059575A2
(en)
|
2008-11-21 |
2010-05-27 |
Isis Pharmaceuticals, Inc. |
Combination therapy for the treatment of cancer
|
|
EP2365803B1
(en)
|
2008-11-24 |
2017-11-01 |
Northwestern University |
Polyvalent rna-nanoparticle compositions
|
|
EP2191834A1
(en)
*
|
2008-11-26 |
2010-06-02 |
Centre National De La Recherche Scientifique (Cnrs) |
Compositions and methods for treating retrovirus infections
|
|
SG171879A1
(en)
|
2008-12-03 |
2011-07-28 |
Marina Biotech Inc |
Usirna complexes
|
|
AU2009322279A1
(en)
|
2008-12-04 |
2011-07-14 |
Opko Pharmaceuticals, Llc |
Compositions and methods for selective inhibition of pro-angiogenic VEGF isoforms
|
|
US20100291188A1
(en)
*
|
2008-12-04 |
2010-11-18 |
Musc Foundation For Research Development |
Periostin Inhibitory Compositions for Myocardial Regeneration, Methods of Delivery, and Methods of Using Same
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
CA2746514C
(en)
|
2008-12-10 |
2018-11-27 |
Alnylam Pharmaceuticals, Inc. |
Gnaq targeted dsrna compositions and methods for inhibiting expression
|
|
WO2010066112A1
(en)
*
|
2008-12-11 |
2010-06-17 |
The University Of Hong Kong |
siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION
|
|
WO2010067882A1
(ja)
*
|
2008-12-12 |
2010-06-17 |
株式会社クレハ |
癌及び喘息治療のための医薬組成物
|
|
EP2370175A2
(en)
|
2008-12-16 |
2011-10-05 |
Bristol-Myers Squibb Company |
Methods of inhibiting quiescent tumor proliferation
|
|
WO2010080452A2
(en)
|
2008-12-18 |
2010-07-15 |
Quark Pharmaceuticals, Inc. |
siRNA COMPOUNDS AND METHODS OF USE THEREOF
|
|
WO2010074540A2
(ko)
|
2008-12-26 |
2010-07-01 |
주식회사 삼양사 |
음이온성 약물 함유 약제학적 조성물 및 그 제조방법
|
|
WO2010078536A1
(en)
|
2009-01-05 |
2010-07-08 |
Rxi Pharmaceuticals Corporation |
Inhibition of pcsk9 through rnai
|
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
|
US8980820B2
(en)
*
|
2009-01-19 |
2015-03-17 |
The Research Foundation For The State University Of New York |
Fatty acid binding proteins as drug targets for endocannabinoids
|
|
WO2010084134A1
(en)
*
|
2009-01-20 |
2010-07-29 |
Vib Vzw |
Phd2 inhibition for blood vessel normalization, and uses thereof
|
|
US9023820B2
(en)
|
2009-01-26 |
2015-05-05 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein C-III expression
|
|
AU2010211133A1
(en)
*
|
2009-02-03 |
2011-07-21 |
F. Hoffmann-La Roche Ag |
Compositions and methods for inhibiting expression of PTP1B genes
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
EP3266795A1
(en)
|
2009-02-12 |
2018-01-10 |
Cell Signaling Technology, Inc. |
Method for detecting a fig-ros fusion polynucleotide
|
|
EP2401375B1
(en)
*
|
2009-02-24 |
2017-08-23 |
RiboxX GmbH |
Improved design of small-interfering rna
|
|
AU2010221419B2
(en)
|
2009-03-02 |
2015-10-01 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
|
JP2012520684A
(ja)
*
|
2009-03-19 |
2012-09-10 |
メルク・シャープ・エンド・ドーム・コーポレイション |
低分子干渉核酸(siNA)を用いたBTBandCNCHomology1(塩基性ロイシンジッパー転写因子1)(Bach1)遺伝子発現のRNA干渉媒介性阻害
|
|
US20100239632A1
(en)
|
2009-03-23 |
2010-09-23 |
Warsaw Orthopedic, Inc. |
Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
|
|
EP2411413B1
(en)
|
2009-03-23 |
2016-05-11 |
Quark Pharmaceuticals, Inc. |
Compounds compositions and methods of treating cancer and fibrotic diseases
|
|
WO2010120874A2
(en)
|
2009-04-14 |
2010-10-21 |
Chimeros, Inc. |
Chimeric therapeutics, compositions, and methods for using same
|
|
WO2010124231A2
(en)
*
|
2009-04-24 |
2010-10-28 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
|
US8367350B2
(en)
|
2009-04-29 |
2013-02-05 |
Morehouse School Of Medicine |
Compositions and methods for diagnosis, prognosis and management of malaria
|
|
US8933049B2
(en)
*
|
2009-05-05 |
2015-01-13 |
Medical Diagnostic Laboratories, Llc |
Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
|
|
EP2427180B1
(en)
|
2009-05-05 |
2016-04-13 |
Beeologics Inc. |
Prevention and treatment of nosema disease in bees
|
|
US9255266B2
(en)
*
|
2009-05-06 |
2016-02-09 |
Rutgers, The State University Of New Jersey |
RNA targeting in alpha-synucleinopathies
|
|
JP2012526533A
(ja)
*
|
2009-05-15 |
2012-11-01 |
エフ.ホフマン−ラ ロシュ アーゲー |
グルココルチコイドレセプター(gcr)遺伝子の発現を阻害するための組成物及び方法
|
|
WO2011005363A2
(en)
*
|
2009-05-18 |
2011-01-13 |
Ensysce Biosciences, Inc. |
Carbon nanotubes complexed with multiple bioactive agents and methods related thereto
|
|
WO2011019423A2
(en)
|
2009-05-20 |
2011-02-17 |
Schering Corporation |
Modulation of pilr receptors to treat microbial infections
|
|
WO2010135669A1
(en)
*
|
2009-05-22 |
2010-11-25 |
Sabiosciences Corporation |
Arrays and methods for reverse genetic functional analysis
|
|
WO2010141511A2
(en)
|
2009-06-01 |
2010-12-09 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotides for multivalent rna interference, compositions and methods of use thereof
|
|
WO2010140024A1
(en)
*
|
2009-06-03 |
2010-12-09 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods for diagnosing and treating a renal disease in an individual
|
|
AU2010256356B2
(en)
|
2009-06-05 |
2015-07-16 |
University Of Florida Research Foundation, Inc. |
Isolation and targeted suppression of lignin biosynthetic genes from sugarcane
|
|
CN102458418B
(zh)
|
2009-06-08 |
2015-09-16 |
夸克制药公司 |
一种寡核苷酸化合物的制药用途
|
|
KR101766408B1
(ko)
|
2009-06-10 |
2017-08-10 |
알닐람 파마슈티칼스 인코포레이티드 |
향상된 지질 조성물
|
|
EP2440666B1
(en)
|
2009-06-10 |
2017-03-01 |
Temasek Life Sciences Laboratory Limited |
Virus induced gene silencing (vigs) for functional analysis of genes in cotton
|
|
US9051567B2
(en)
|
2009-06-15 |
2015-06-09 |
Tekmira Pharmaceuticals Corporation |
Methods for increasing efficacy of lipid formulated siRNA
|
|
JP5894913B2
(ja)
|
2009-06-15 |
2016-03-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Pcsk9遺伝子を標的とする、脂質で製剤化されたdsrna
|
|
US20100324124A1
(en)
*
|
2009-06-17 |
2010-12-23 |
Massachusetts Institute Of Technology |
Compositions and methods relating to DNA-based particles
|
|
US20100323018A1
(en)
*
|
2009-06-17 |
2010-12-23 |
Massachusetts Institute Of Technology |
Branched DNA/RNA monomers and uses thereof
|
|
GB0910723D0
(en)
*
|
2009-06-22 |
2009-08-05 |
Sylentis Sau |
Novel drugs for inhibition of gene expression
|
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
WO2011000107A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
|
EP2454371B1
(en)
|
2009-07-13 |
2021-01-20 |
Somagenics, Inc. |
Chemical modification of small hairpin rnas for inhibition of gene expression
|
|
PT2769737T
(pt)
|
2009-07-20 |
2017-06-29 |
Bristol Myers Squibb Co |
Combinação de um anticorpo anti-ctla4 com etopósido para o tratamento sinérgico de doenças proliferativas
|
|
US8716464B2
(en)
|
2009-07-20 |
2014-05-06 |
Thomas W. Geisbert |
Compositions and methods for silencing Ebola virus gene expression
|
|
CA2769822C
(en)
|
2009-08-13 |
2019-02-19 |
The Johns Hopkins University |
Methods of modulating immune function
|
|
AP2015008874A0
(en)
|
2009-08-14 |
2015-11-30 |
Alnylam Pharmaceuticals Inc |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
|
JP2013503162A
(ja)
|
2009-08-24 |
2013-01-31 |
ファイジェニクス インコーポレイテッド |
乳癌の治療を目的としたpax2ターゲティング
|
|
EP2475388B1
(en)
|
2009-09-10 |
2017-11-08 |
Merck Sharp & Dohme Corp. |
Use of il-33 antagonists to treat fibrotic disease
|
|
EP2295543A1
(en)
|
2009-09-11 |
2011-03-16 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Method for the preparation of an influenza virus
|
|
WO2011032100A1
(en)
|
2009-09-11 |
2011-03-17 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Inhibitors of kshv vil6 and human il6
|
|
CN107519133A
(zh)
|
2009-09-15 |
2017-12-29 |
阿尔尼拉姆医药品有限公司 |
脂质配制的组合物及抑制Eg5和VEGF基因的表达的方法
|
|
WO2011035065A1
(en)
|
2009-09-17 |
2011-03-24 |
Nektar Therapeutics |
Monoconjugated chitosans as delivery agents for small interfering nucleic acids
|
|
US9187746B2
(en)
|
2009-09-22 |
2015-11-17 |
Alnylam Pharmaceuticals, Inc. |
Dual targeting siRNA agents
|
|
US9222086B2
(en)
*
|
2009-09-23 |
2015-12-29 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing genes expressed in cancer
|
|
US20150025122A1
(en)
|
2009-10-12 |
2015-01-22 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
|
US8962584B2
(en)
|
2009-10-14 |
2015-02-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Compositions for controlling Varroa mites in bees
|
|
CA2779099C
(en)
|
2009-10-30 |
2021-08-10 |
Northwestern University |
Templated nanoconjugates
|
|
US9101643B2
(en)
|
2009-11-03 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of transthyretin (TTR)
|
|
US9799416B2
(en)
*
|
2009-11-06 |
2017-10-24 |
Terrapower, Llc |
Methods and systems for migrating fuel assemblies in a nuclear fission reactor
|
|
WO2011057171A1
(en)
|
2009-11-08 |
2011-05-12 |
Quark Pharmaceuticals, Inc. |
METHODS FOR DELIVERY OF siRNA TO THE SPINAL CORD AND THERAPIES ARISING THEREFROM
|
|
US9260517B2
(en)
|
2009-11-17 |
2016-02-16 |
Musc Foundation For Research Development |
Human monoclonal antibodies to human nucleolin
|
|
AU2010324658A1
(en)
|
2009-11-26 |
2012-05-03 |
Quark Pharmaceuticals, Inc. |
siRNA compounds comprising terminal substitutions
|
|
EP3296398A1
(en)
|
2009-12-07 |
2018-03-21 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
|
WO2011072082A2
(en)
*
|
2009-12-09 |
2011-06-16 |
Nitto Denko Corporation |
Modulation of hsp47 expression
|
|
EP2862929B1
(en)
|
2009-12-09 |
2017-09-06 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treating diseases, disorders or injury of the CNS
|
|
WO2011072240A1
(en)
|
2009-12-10 |
2011-06-16 |
Cedars-Sinai Medical Center |
Drug delivery of temozolomide for systemic based treatment of cancer
|
|
EP2336171A1
(en)
|
2009-12-11 |
2011-06-22 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Novel targets for the treatment of proliferative diseases
|
|
EP2513308B1
(en)
|
2009-12-17 |
2017-01-18 |
Merck Sharp & Dohme Corp. |
Modulation of pilr to treat immune disorders
|
|
EP3000885B1
(en)
|
2009-12-18 |
2018-07-25 |
Arrowhead Pharmaceuticals, Inc. |
Organic compositions to treat hsf1-related diseases
|
|
EP3494963A1
(en)
|
2009-12-18 |
2019-06-12 |
The University of British Columbia |
Methods and compositions for delivery of nucleic acids
|
|
WO2011076873A1
(en)
|
2009-12-23 |
2011-06-30 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Influenza targets
|
|
SG181880A1
(en)
|
2009-12-23 |
2012-07-30 |
Gradalis Inc |
Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
|
|
US20130023578A1
(en)
|
2009-12-31 |
2013-01-24 |
Samyang Biopharmaceuticals Corporation |
siRNA for inhibition of c-Met expression and anticancer composition containing the same
|
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
|
TW201124159A
(en)
*
|
2010-01-07 |
2011-07-16 |
Univ Nat Cheng Kung |
Small interference RNA molecule and applications thereof
|
|
JP6027893B2
(ja)
*
|
2010-01-11 |
2016-11-16 |
カッパーアールエヌエー,インコーポレイテッド |
性ホルモン結合グロブリン(shbg)に対する天然アンチセンス転写物の阻害による性ホルモン結合グロブリン(shbg)関連疾患の治療
|
|
WO2011088058A1
(en)
*
|
2010-01-12 |
2011-07-21 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expressions of factor vii and pten genes
|
|
DE102010004957A1
(de)
|
2010-01-14 |
2011-07-21 |
Universitätsklinikum Jena, 07743 |
Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
|
|
US9198972B2
(en)
|
2010-01-28 |
2015-12-01 |
Alnylam Pharmaceuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
|
US8722641B2
(en)
|
2010-01-29 |
2014-05-13 |
St. Jude Children's Research Hospital |
Oligonucleotides which inhibit p53 induction in response to cellular stress
|
|
US20120296403A1
(en)
|
2010-02-10 |
2012-11-22 |
Novartis Ag |
Methods and compounds for muscle growth
|
|
CA2793521A1
(en)
|
2010-03-19 |
2011-09-22 |
University Of South Alabama |
Use of antisense gli1 for reducing the dosage of a therapeutic compound to treat needed to treat a cancer
|
|
RU2615143C2
(ru)
|
2010-03-24 |
2017-04-04 |
Адвирна |
Самодоставляющие PHKi соединения уменьшенного размера
|
|
CN103200945B
(zh)
|
2010-03-24 |
2016-07-06 |
雷克西制药公司 |
眼部症候中的rna干扰
|
|
EP3560503B1
(en)
|
2010-03-24 |
2021-11-17 |
Phio Pharmaceuticals Corp. |
Rna interference in dermal and fibrotic indications
|
|
US8455455B1
(en)
|
2010-03-31 |
2013-06-04 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing genes involved in hemorrhagic fever
|
|
US9102938B2
(en)
|
2010-04-01 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
2′ and 5′ modified monomers and oligonucleotides
|
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
|
WO2011133658A1
(en)
|
2010-04-22 |
2011-10-27 |
Boston Medical Center Corporation |
Compositions and methods for targeting and delivering therapeutics into cells
|
|
PL2563920T3
(pl)
|
2010-04-29 |
2017-08-31 |
Ionis Pharmaceuticals, Inc. |
Modulacja ekspresji transtyretyny
|
|
EP2563359A1
(en)
|
2010-04-30 |
2013-03-06 |
Allergan, Inc. |
Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
|
|
KR20190000385A
(ko)
|
2010-05-04 |
2019-01-02 |
더 브리검 앤드 우먼즈 하스피털, 인크. |
섬유증의 검출 및 치료
|
|
US8563243B2
(en)
*
|
2010-05-12 |
2013-10-22 |
University Of South Carolina |
Methods for affecting homology-directed DNA double stranded break repair
|
|
CA2798739A1
(en)
|
2010-05-26 |
2011-12-01 |
Selecta Biosciences, Inc. |
Nanocarrier compositions with uncoupled adjuvant
|
|
EP2390327A1
(en)
|
2010-05-27 |
2011-11-30 |
Sylentis S.A. |
siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
|
DE102010022937A1
(de)
|
2010-06-04 |
2011-12-08 |
Universitätsklinikum Jena |
Zellspezifisch aktivierbare biologisch wirksame Moleküle auf Grundlage von siRNA, Verfahren zu deren Aktivierung sowie Applikationskit zur Verabreichung
|
|
US20130236968A1
(en)
|
2010-06-21 |
2013-09-12 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
|
CN103097534B
(zh)
|
2010-06-24 |
2017-07-28 |
夸克制药公司 |
针对rhoa的双链rna化合物及其用途
|
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
US20120101108A1
(en)
|
2010-08-06 |
2012-04-26 |
Cell Signaling Technology, Inc. |
Anaplastic Lymphoma Kinase In Kidney Cancer
|
|
US9243246B2
(en)
|
2010-08-24 |
2016-01-26 |
Sirna Therapeutics, Inc. |
Single-stranded RNAi agents containing an internal, non-nucleic acid spacer
|
|
EP2622076A1
(en)
|
2010-09-30 |
2013-08-07 |
University of Zürich |
Treatment of b-cell lymphoma with microrna
|
|
US20140315973A1
(en)
*
|
2010-10-07 |
2014-10-23 |
Agency For Science, Technology And Research |
Parp-1 inhibitors
|
|
WO2012051491A1
(en)
|
2010-10-14 |
2012-04-19 |
The United States Of America, As Represented By The Secretary National Institutes Of Health |
Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
|
|
DK2631291T3
(da)
|
2010-10-22 |
2019-06-11 |
Olix Pharmaceuticals Inc |
Nukleinsyremolekyler, der inducerer rna-interferens, og anvendelser deraf
|
|
WO2012058210A1
(en)
|
2010-10-29 |
2012-05-03 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
|
|
WO2012071436A1
(en)
|
2010-11-24 |
2012-05-31 |
Genentech, Inc. |
Method of treating autoimmune inflammatory disorders using il-23r loss-of-function mutants
|
|
AU2011338682B2
(en)
|
2010-12-06 |
2017-04-27 |
Quark Pharmaceuticals, Inc. |
Double stranded oligonucleotide compounds comprising threose modifications
|
|
WO2012102793A2
(en)
|
2010-12-10 |
2012-08-02 |
Zirus, Inc. |
Mammalian genes involved in toxicity and infection
|
|
US8575328B2
(en)
*
|
2010-12-14 |
2013-11-05 |
The United States Of America, As Represented By The Secretary Of Agriculture |
Formicidae (ant) control using double-stranded RNA constructs
|
|
US9623041B2
(en)
|
2010-12-30 |
2017-04-18 |
Cedars-Sinai Medical Center |
Polymalic acid-based nanobiopolymer compositions
|
|
AU2012205718B2
(en)
|
2011-01-10 |
2017-07-06 |
The Regents Of The University Of Michigan |
Stem cell factor inhibitor
|
|
US20150018408A1
(en)
|
2013-07-10 |
2015-01-15 |
The Regents Of The University Of Michigan |
Therapeutic antibodies and uses thereof
|
|
CA2824526C
(en)
|
2011-01-11 |
2020-07-07 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
|
DE102011009470A1
(de)
|
2011-01-21 |
2012-08-09 |
Friedrich-Schiller-Universität Jena |
Biologisch wirksame Nukleotid-Moleküle zur gezielten Abtötung von Zellen, Verwendung derselben sowie Applikationskit
|
|
PT2670411T
(pt)
|
2011-02-02 |
2019-06-18 |
Excaliard Pharmaceuticals Inc |
Compostos anti sentido visando um fator de crescimento do tecido conetivo (ctfg) para utilização num método de tratamento de queloides ou cicatrizes hipertróficas
|
|
JP2014506789A
(ja)
|
2011-02-03 |
2014-03-20 |
マーナ セラピューティクス インコーポレイテッド |
miR−124の合成模倣体
|
|
CA2828544A1
(en)
*
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
|
US9796979B2
(en)
|
2011-03-03 |
2017-10-24 |
Quark Pharmaceuticals Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
|
US9233121B2
(en)
*
|
2011-03-11 |
2016-01-12 |
Board Of Regents Of The University Of Nebraska |
Compositions and methods for the treatment of cancer
|
|
BR112013023724A2
(pt)
|
2011-03-15 |
2019-09-24 |
Univ Utah Res Found |
métodos para tratar doença ou sintoma, detriagem para um agente ou uma combinação de agentes, e para determinar a eficácia de um agente e de um tratamento
|
|
US9458456B2
(en)
*
|
2011-04-01 |
2016-10-04 |
University Of South Alabama |
Methods and compositions for the diagnosis, classification, and treatment of cancer
|
|
EP2686342A2
(en)
|
2011-04-12 |
2014-01-22 |
The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services |
Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
|
|
CN103547588B
(zh)
|
2011-04-13 |
2016-06-29 |
Isis制药公司 |
Ptp1b表达的反义调节
|
|
WO2012142622A1
(en)
|
2011-04-15 |
2012-10-18 |
Molecular Transfer, Inc. |
Agents for improved delivery of nucleic acids to eukaryotic cells
|
|
US8716257B2
(en)
*
|
2011-04-15 |
2014-05-06 |
Sutter West Bay Hospitals |
CMV gene products promote cancer stem cell growth
|
|
WO2012161856A1
(en)
|
2011-05-20 |
2012-11-29 |
Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services |
Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof
|
|
PL3446714T3
(pl)
|
2011-06-02 |
2021-11-22 |
University Of Louisville Research Foundation, Inc. |
Nanocząstki sprzężone z cząsteczką skierowaną przeciwko nukleolinie
|
|
EP3388068A1
(en)
|
2011-06-21 |
2018-10-17 |
Alnylam Pharmaceuticals, Inc. |
Composition and methods for inhibition of expression of protein c (proc) genes
|
|
EP2723758B1
(en)
|
2011-06-21 |
2018-06-20 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof
|
|
MX390699B
(es)
|
2011-06-21 |
2025-03-21 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para inhibicion de genes para apolipoproteina c-iii (apoc3).
|
|
EP2723861A4
(en)
|
2011-06-21 |
2014-12-10 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR INHIBITING HEPCIDINE ANTIMICROBIAL PEPTIDE (HAMP) OR THE ASSOCIATED GENE EXPRESSION
|
|
US20140227293A1
(en)
|
2011-06-30 |
2014-08-14 |
Trustees Of Boston University |
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
|
|
WO2013001372A2
(en)
|
2011-06-30 |
2013-01-03 |
University Of Oslo |
Methods and compositions for inhibition of activation of regulatory t cells
|
|
EA029234B1
(ru)
|
2011-07-06 |
2018-02-28 |
Сюкехусет Сёрланнет Хф |
Нацеленная на egfr терапия
|
|
WO2013006861A1
(en)
|
2011-07-07 |
2013-01-10 |
University Of Georgia Research Foundation, Inc. |
Sorghum grain shattering gene and uses thereof in altering seed dispersal
|
|
US8853181B2
(en)
|
2011-07-21 |
2014-10-07 |
Albert Einstein College Of Medicine Of Yeshiva University |
Fidgetin-like 2 as a target to enhance wound healing
|
|
US9120858B2
(en)
|
2011-07-22 |
2015-09-01 |
The Research Foundation Of State University Of New York |
Antibodies to the B12-transcobalamin receptor
|
|
DE102011118024A1
(de)
|
2011-08-01 |
2013-02-07 |
Technische Universität Dresden |
Inhibitor der Expression der Pro-Caspase 1
|
|
EP2753696B1
(en)
|
2011-09-06 |
2017-11-22 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
The mirna-212/132 family as a therapeutic target
|
|
CA2847888A1
(en)
|
2011-09-09 |
2013-03-14 |
Biomed Realty, L.P. |
Methods and compositions for controlling assembly of viral proteins
|
|
WO2013040251A2
(en)
|
2011-09-13 |
2013-03-21 |
Asurgen, Inc. |
Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
|
|
US9951349B2
(en)
|
2011-09-27 |
2018-04-24 |
Yale University |
Compositions and methods for transient expression of recombinant RNA
|
|
EP3456317B1
(en)
|
2011-09-27 |
2025-09-24 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
|
CN107266391B
(zh)
|
2011-10-18 |
2020-04-17 |
迪克纳制药公司 |
胺阳离子脂质及其用途
|
|
US20140323549A1
(en)
|
2011-11-08 |
2014-10-30 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the nervous system
|
|
EP2725103A3
(en)
|
2011-11-14 |
2016-01-06 |
Silenseed Ltd |
Methods and compositions for treating prostate cancer
|
|
EP3730618A1
(en)
|
2011-11-18 |
2020-10-28 |
Alnylam Pharmaceuticals, Inc. |
Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases
|
|
WO2013082529A1
(en)
|
2011-12-02 |
2013-06-06 |
Yale University |
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
|
|
JP2015509085A
(ja)
|
2012-01-01 |
2015-03-26 |
キュービーアイ エンタープライゼズ リミテッドQbi Enterprises Ltd. |
治療剤および診断剤の選択的送達のためのendo180を標的とする粒子
|
|
WO2013103401A1
(en)
*
|
2012-01-06 |
2013-07-11 |
University Of South Alabama |
Methods and compositions for the treatment of cancer
|
|
EP2802658A2
(en)
|
2012-01-09 |
2014-11-19 |
Novartis AG |
Rnai agents to treat beta-catenin related diseases
|
|
BR112014016937A2
(pt)
|
2012-01-12 |
2017-06-13 |
Quark Pharmaceuticals Inc |
terapia de combinação para o tratamento de desordens de audição e do equilíbrio
|
|
WO2013112458A1
(en)
|
2012-01-24 |
2013-08-01 |
Beth Israel Deaconess Medical Center, Inc. |
Novel chrebp isoforms and methods using the same
|
|
WO2013138456A1
(en)
|
2012-03-14 |
2013-09-19 |
University Of Central Florida Research Foundation, Inc. |
Lim kinasemodulating agents for neurofibromatoses therapy and methods for screening for same
|
|
HK1210211A1
(en)
|
2012-03-15 |
2016-04-15 |
科纳公司 |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
|
PL2838998T3
(pl)
|
2012-04-18 |
2018-04-30 |
Cell Signaling Technology, Inc. |
EGFR i ROS1 w nowotworze
|
|
US9980942B2
(en)
|
2012-05-02 |
2018-05-29 |
Children's Hospital Medical Center |
Rejuvenation of precursor cells
|
|
US20150299696A1
(en)
|
2012-05-02 |
2015-10-22 |
Sirna Therapeutics, Inc. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
|
KR101567576B1
(ko)
|
2012-05-22 |
2015-11-10 |
올릭스 주식회사 |
세포 내 관통능을 가지고 rna 간섭을 유도하는 핵산 분자 및 그 용도
|
|
EP2867368B1
(en)
|
2012-07-06 |
2022-01-12 |
Institut Gustave Roussy |
Simultaneous detection of cannibalism and senescence as prognostic marker for cancer
|
|
WO2014018375A1
(en)
|
2012-07-23 |
2014-01-30 |
Xenon Pharmaceuticals Inc. |
Cyp8b1 and uses thereof in therapeutic and diagnostic methods
|
|
US9655977B2
(en)
|
2012-08-31 |
2017-05-23 |
The General Hospital Corporation |
Biotin complexes for treatment and diagnosis of alzheimer's disease
|
|
AU2012389270B2
(en)
|
2012-09-05 |
2018-11-08 |
Sylentis S.A.U. |
siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
|
GB201215857D0
(en)
|
2012-09-05 |
2012-10-24 |
Sylentis Sau |
siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
|
ES2704855T3
(es)
|
2012-09-12 |
2019-03-20 |
Quark Pharmaceuticals Inc |
Moléculas de oligonucleótido de doble cadena para p53 y métodos de uso de las mismas
|
|
EP2895607B1
(en)
|
2012-09-12 |
2021-05-05 |
Quark Pharmaceuticals, Inc. |
Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof
|
|
PL2897620T3
(pl)
|
2012-09-21 |
2020-11-02 |
Intensity Therapeutics, Inc |
Sposób leczenia nowotworu złośliwego
|
|
WO2014055624A1
(en)
*
|
2012-10-02 |
2014-04-10 |
The General Hospital Corporation D/B/A Massachusetts General Hospital |
Methods relating to dna-sensing pathway related conditions
|
|
WO2014055825A1
(en)
|
2012-10-04 |
2014-04-10 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
A formulation of mycobacterial components as an adjuvant for inducing th17 responses
|
|
WO2014068072A1
(en)
|
2012-10-31 |
2014-05-08 |
Institut Gustave-Roussy |
Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
|
|
CN105051192B
(zh)
*
|
2012-11-13 |
2020-04-17 |
科迪艾克生物科学公司 |
治疗剂的递送
|
|
MX366404B
(es)
|
2012-11-15 |
2019-07-08 |
Apellis Pharmaceuticals Inc |
Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados.
|
|
DE102012022596B4
(de)
|
2012-11-15 |
2017-05-04 |
Friedrich-Schiller-Universität Jena |
Neue zellspezifisch wirksame Nukleotid-Moleküle und Applikationskit zu deren Anwendung
|
|
CN109554350B
(zh)
|
2012-11-27 |
2022-09-23 |
儿童医疗中心有限公司 |
用于胎儿血红蛋白再诱导的靶向bcl11a远端调控元件
|
|
IL292159B1
(en)
|
2012-12-05 |
2026-04-01 |
Alnylam Pharmaceuticals Inc |
PCSK9 iRNA compositions and methods of using them
|
|
WO2014093688A1
(en)
|
2012-12-12 |
2014-06-19 |
1Massachusetts Institute Of Technology |
Compositions and methods for functional nucleic acid delivery
|
|
CA2891855A1
(en)
|
2012-12-21 |
2014-06-26 |
Sykehuset Sorlandet Hf |
Egfr targeted therapy of neurological disorders and pain
|
|
US9206423B2
(en)
*
|
2012-12-30 |
2015-12-08 |
The Regents Of The University Of California |
Methods of modulating compliance of the trabecular meshwork
|
|
WO2014113541A1
(en)
|
2013-01-16 |
2014-07-24 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Attenuated chlamydia vaccine
|
|
DE102013003869B4
(de)
|
2013-02-27 |
2016-11-24 |
Friedrich-Schiller-Universität Jena |
Verfahren zur gezielten Abtötung von Zellen durch zur mRNA-Anbindung ausgerichtete Nukleotid-Moleküle sowie Nukleotid-Moleküle und Applikationskit für solche Verwendung
|
|
CN105142614A
(zh)
|
2013-03-14 |
2015-12-09 |
迪克纳制药公司 |
用于配制阴离子试剂的方法
|
|
WO2014150751A2
(en)
*
|
2013-03-15 |
2014-09-25 |
Novartis Ag |
Biomarkers associated with brm inhibition
|
|
WO2014152391A1
(en)
|
2013-03-15 |
2014-09-25 |
Apellis Pharmaceuticals, Inc. |
Cell-penetrating compstatin analogs and uses thereof
|
|
JP2016519672A
(ja)
*
|
2013-03-15 |
2016-07-07 |
ジェネンテック, インコーポレイテッド |
ブロモドメイン含有タンパク質brd7およびbrd9の阻害によるth2媒介性疾患の治療
|
|
US9937231B2
(en)
|
2013-03-27 |
2018-04-10 |
The General Hospital Corporation |
Methods and agents for treating Alzheimer's disease
|
|
CA2912801A1
(en)
|
2013-05-17 |
2014-11-20 |
Medimmune, Llc |
Receptors for b7-h4
|
|
CA2916533C
(en)
|
2013-06-25 |
2022-12-20 |
University Of Canberra |
Methods and compositions for modulating cancer stem cells
|
|
TW201534578A
(zh)
|
2013-07-08 |
2015-09-16 |
Daiichi Sankyo Co Ltd |
新穎脂質
|
|
RU2703498C2
(ru)
|
2013-07-19 |
2019-10-17 |
Монсанто Текнолоджи Ллс |
Композиции и способы борьбы с leptinotarsa
|
|
WO2015013510A1
(en)
|
2013-07-25 |
2015-01-29 |
Ecole Polytechnique Federale De Lausanne Epfl |
High aspect ratio nanofibril materials
|
|
CN105452465B
(zh)
|
2013-07-31 |
2019-06-21 |
奇比艾企业有限公司 |
鞘脂-聚烷基胺-寡核苷酸化合物
|
|
EP3027223A1
(en)
|
2013-07-31 |
2016-06-08 |
QBI Enterprises Ltd. |
Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
|
|
KR102365486B1
(ko)
*
|
2013-08-28 |
2022-02-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
프리칼리크레인 (pkk) 발현의 조절
|
|
IL312865B2
(en)
|
2013-09-11 |
2025-06-01 |
Eagle Biologics Inc |
Liquid protein formulations containing viscosity-lowering agents
|
|
ES2851724T3
(es)
|
2013-09-18 |
2021-09-08 |
Epiaxis Therapeutics Pty Ltd |
Modulación de células madre
|
|
EP3052464B1
(en)
|
2013-10-04 |
2020-04-15 |
Novartis AG |
3'end caps for rna-interferring agents for use in rna interference
|
|
HK1221912A1
(zh)
|
2013-10-04 |
2017-06-16 |
Novartis Ag |
用於治疗乙肝病毒的有机化合物
|
|
EP2865758A1
(en)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA and their use in methods and compositions for inhibiting the expression of the ORAI1 gene
|
|
EP2865757A1
(en)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA and their use in methods and compositions for inhibiting the expression of the PDK1 gene.
|
|
EP2865756A1
(en)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA and their use in methods and compositions for inhibiting the expression of the FLAP gene.
|
|
US10004814B2
(en)
|
2013-11-11 |
2018-06-26 |
Sirna Therapeutics, Inc. |
Systemic delivery of myostatin short interfering nucleic acids (siNA) conjugated to a lipophilic moiety
|
|
EP3071590A4
(en)
|
2013-11-21 |
2017-07-19 |
SeNA Research, Inc. |
Methods for structural determination of selenium derivatized nucleic acid complexes
|
|
CN106061488B
(zh)
|
2013-12-02 |
2021-04-09 |
菲奥医药公司 |
癌症的免疫治疗
|
|
US10150965B2
(en)
|
2013-12-06 |
2018-12-11 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA
|
|
CN104830906B
(zh)
|
2014-02-12 |
2018-09-04 |
北京维通达生物技术有限公司 |
一种重编程获得功能性人肝脏实质细胞的方法
|
|
US10011837B2
(en)
|
2014-03-04 |
2018-07-03 |
Sylentis Sau |
SiRNAs and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
|
JP6681837B2
(ja)
|
2014-03-11 |
2020-04-15 |
セレクティスCellectis |
同種移植に適合するt細胞を作製するための方法
|
|
EP3119887B1
(en)
*
|
2014-03-20 |
2019-02-20 |
Oommen Varghese |
Improved small interfering ribonucleic acid molecules
|
|
US9856475B2
(en)
|
2014-03-25 |
2018-01-02 |
Arcturus Therapeutics, Inc. |
Formulations for treating amyloidosis
|
|
JP6771387B2
(ja)
|
2014-03-25 |
2020-10-21 |
アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. |
遺伝子サイレンシング用トランスサイレチン対立遺伝子選択的unaオリゴマー
|
|
AU2015236215B2
(en)
|
2014-03-25 |
2020-03-19 |
Arcturus Therapeutics, Inc. |
UNA oligomers having reduced off-target effects in gene silencing
|
|
BR112016022711A2
(pt)
|
2014-04-01 |
2017-10-31 |
Monsanto Technology Llc |
composições e métodos para controle de pragas de inseto
|
|
HUE050704T2
(hu)
|
2014-04-01 |
2020-12-28 |
Biogen Ma Inc |
Összetételek a SOD-1 expressziójának modulálására
|
|
MX375592B
(es)
|
2014-04-25 |
2025-03-06 |
The Children´S Medical Center Corp |
Composiciones y su uso para tratar hemoglobinopatias.
|
|
WO2015168108A2
(en)
|
2014-04-28 |
2015-11-05 |
Rxi Pharmaceuticals Corporation |
Methods for treating cancer using nucleic targeting mdm2 or mycn
|
|
HUE052709T2
(hu)
|
2014-05-01 |
2021-05-28 |
Ionis Pharmaceuticals Inc |
Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására
|
|
US20170073401A1
(en)
|
2014-05-02 |
2017-03-16 |
Research Institute At Nationwide Children's Hospital |
Compositions and methods for anti-lyst immunomodulation
|
|
US10335500B2
(en)
|
2014-05-12 |
2019-07-02 |
The Johns Hopkins University |
Highly stable biodegradable gene vector platforms for overcoming biological barriers
|
|
JP6763780B2
(ja)
|
2014-05-12 |
2020-09-30 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
合成脳浸透遺伝子ベクターの操作
|
|
US10100308B2
(en)
|
2014-05-29 |
2018-10-16 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
|
TR201908550T4
(tr)
|
2014-06-04 |
2019-07-22 |
Exicure Inc |
Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
|
|
TW201620526A
(zh)
|
2014-06-17 |
2016-06-16 |
愛羅海德研究公司 |
用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
|
|
CN104120127B
(zh)
*
|
2014-07-01 |
2016-09-21 |
清华大学 |
分离的寡核苷酸及其应用
|
|
RU2021123470A
(ru)
|
2014-07-29 |
2021-09-06 |
Монсанто Текнолоджи Ллс |
Композиции и способы борьбы с насекомыми-вредителями
|
|
WO2016019126A1
(en)
|
2014-07-30 |
2016-02-04 |
The Research Foundation For The State University Of New York |
System and method for delivering genetic material or protein to cells
|
|
US20200230251A1
(en)
|
2014-08-14 |
2020-07-23 |
Friedrich-Schiller-Universitaet Jena |
Peptide for use in the reduction of side effects in the form of immunostimulatory reactions/effects
|
|
WO2016028940A1
(en)
|
2014-08-19 |
2016-02-25 |
Northwestern University |
Protein/oligonucleotide core-shell nanoparticle therapeutics
|
|
CA2958704A1
(en)
|
2014-08-25 |
2016-03-03 |
University Of Canberra |
Compositions for modulating cancer stem cells and uses therefor
|
|
CN113599539A
(zh)
|
2014-08-29 |
2021-11-05 |
阿尔尼拉姆医药品有限公司 |
治疗甲状腺素运载蛋白(ttr)介导的淀粉样变性的方法
|
|
US10900039B2
(en)
|
2014-09-05 |
2021-01-26 |
Phio Pharmaceuticals Corp. |
Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
|
|
EP3194581A4
(en)
|
2014-09-15 |
2018-04-25 |
Children's Medical Center Corporation |
Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
|
|
CA2962406A1
(en)
|
2014-09-25 |
2016-03-31 |
Cold Spring Harbor Laboratory |
Treatment of rett syndrome
|
|
AU2015325055B2
(en)
|
2014-10-01 |
2021-02-25 |
Eagle Biologics, Inc. |
Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
|
|
WO2016057693A1
(en)
|
2014-10-10 |
2016-04-14 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
|
JP6991857B2
(ja)
|
2014-10-10 |
2022-01-13 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Tlr9アゴニストをチェックポイント阻害剤と共に用いるがんの治療
|
|
TW202503057A
(zh)
|
2014-10-10 |
2025-01-16 |
美商艾爾妮蘭製藥公司 |
用於抑制hao1(羥酸氧化酶1(乙醇酸鹽氧化酶))基因表現的組合物及方法
|
|
US10538762B2
(en)
*
|
2014-10-14 |
2020-01-21 |
The Board Of Regents Of The University Of Texas System |
Allele selective inhibition of mutant C9orf72 foci expression by duplex RNAS targeting the expanded hexanucleotide repeat
|
|
EP3209794A1
(en)
|
2014-10-22 |
2017-08-30 |
Katholieke Universiteit Leuven KU Leuven Research & Development |
Modulating adipose tissue and adipogenesis
|
|
KR102545316B1
(ko)
|
2014-11-10 |
2023-06-22 |
알닐람 파마슈티칼스 인코포레이티드 |
B형 간염 바이러스(hbv) irna 조성물 및 그의 이용 방법
|
|
WO2016077624A1
(en)
|
2014-11-12 |
2016-05-19 |
Nmc, Inc. |
Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same
|
|
JP2017535552A
(ja)
|
2014-11-17 |
2017-11-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
アポリポタンパク質C3(APOC3)iRNA組成物およびその使用方法
|
|
WO2016081621A1
(en)
|
2014-11-18 |
2016-05-26 |
Yale University |
Formulations for targeted release of agents under low ph conditions and methods of use thereof
|
|
US11213593B2
(en)
|
2014-11-21 |
2022-01-04 |
Northwestern University |
Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
|
US20190002876A1
(en)
*
|
2014-12-09 |
2019-01-03 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods for treatment of friedreich's ataxia
|
|
US20180002702A1
(en)
*
|
2014-12-26 |
2018-01-04 |
Nitto Denko Corporation |
Methods and compositions for treating malignant tumors associated with kras mutation
|
|
US10264976B2
(en)
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
|
US10792299B2
(en)
|
2014-12-26 |
2020-10-06 |
Nitto Denko Corporation |
Methods and compositions for treating malignant tumors associated with kras mutation
|
|
JP6942632B2
(ja)
|
2015-01-22 |
2021-09-29 |
モンサント テクノロジー エルエルシー |
Leptinotarsa防除用組成物及びその方法
|
|
US10519447B2
(en)
|
2015-04-01 |
2019-12-31 |
Arcturus Therapeutics, Inc. |
Therapeutic UNA oligomers and uses thereof
|
|
US20160319278A1
(en)
|
2015-04-03 |
2016-11-03 |
University Of Massachusetts |
Fully stabilized asymmetric sirna
|
|
CN115927335A
(zh)
|
2015-04-13 |
2023-04-07 |
阿尔尼拉姆医药品有限公司 |
类血管生成素3(ANGPTL3)iRNA组合物及其使用方法
|
|
WO2016168197A1
(en)
|
2015-04-15 |
2016-10-20 |
Yale University |
Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof
|
|
HK1251488A1
(zh)
|
2015-05-05 |
2019-02-01 |
The University Of Louisville Research Foundation, Inc. |
作为放射致敏剂以及mri和/或x光造影剂的结合纳米粒子的抗核仁素剂
|
|
US11572543B2
(en)
|
2015-05-08 |
2023-02-07 |
The Children's Medical Center. Corporation |
Targeting BCL11A enhancer functional regions for fetal hemoglobin reinduction
|
|
EP3302710A4
(en)
|
2015-06-03 |
2019-02-20 |
The University of Queensland |
MOBILIZERS AND USE THEREOF
|
|
EP3307890A1
(en)
|
2015-06-10 |
2018-04-18 |
Board of Regents, The University of Texas System |
Use of exosomes for the treatment of disease
|
|
WO2017002928A1
(ja)
|
2015-06-30 |
2017-01-05 |
岸本 忠三 |
新規な肺疾患治療剤および/またはそのスクリーニング方法
|
|
EP3862005A1
(en)
|
2015-07-06 |
2021-08-11 |
Phio Pharmaceuticals Corp. |
Nucleic acid molecules targeting superoxide dismutase 1 (sod1)
|
|
US10808247B2
(en)
|
2015-07-06 |
2020-10-20 |
Phio Pharmaceuticals Corp. |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
MX2018000412A
(es)
|
2015-07-10 |
2018-03-14 |
Ionis Pharmaceuticals Inc |
Moduladores de diaciglicerol aciltransferasa 2 (dgat2).
|
|
WO2017015671A1
(en)
|
2015-07-23 |
2017-01-26 |
Arcturus Therapeutics, Inc. |
Compositions for treating amyloidosis
|
|
PT3329002T
(pt)
|
2015-07-31 |
2021-01-12 |
Alnylam Pharmaceuticals Inc |
Composições de iarn de transtirretina (ttr) e métodos de seu uso para tratamento ou prevenção de doenças associadas à ttr
|
|
WO2017030973A1
(en)
|
2015-08-14 |
2017-02-23 |
University Of Massachusetts |
Bioactive conjugates for oligonucleotide delivery
|
|
WO2017035278A1
(en)
|
2015-08-24 |
2017-03-02 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
|
|
US10752896B2
(en)
|
2015-09-08 |
2020-08-25 |
Sylentis Sau |
siRNA and their use in methods and compositions for inhibiting the expression of the NRARP gene
|
|
GB201516685D0
(en)
*
|
2015-09-21 |
2015-11-04 |
Varghese Oommen P And Oommen Oommen P |
Nucleic acid molecules with enhanced activity
|
|
WO2017053851A1
(en)
|
2015-09-23 |
2017-03-30 |
Massachusetts Institute Of Technology |
Compositions and methods for modified dendrimer nanoparticle vaccine delivery
|
|
US10383935B2
(en)
|
2015-09-23 |
2019-08-20 |
Regents Of The University Of Minnesota |
Methods of making and using live attenuated viruses
|
|
US10086063B2
(en)
|
2015-09-23 |
2018-10-02 |
Regents Of The University Of Minnesota |
Methods of making and using live attenuated viruses
|
|
EP3356415B1
(en)
|
2015-09-29 |
2024-05-01 |
Amgen Inc. |
Asgr inhibitors for reduzing cholesterol levels
|
|
JOP20160211B1
(ar)
|
2015-10-01 |
2021-08-17 |
Arrowhead Pharmaceuticals Inc |
تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
|
|
US11903994B2
(en)
|
2015-10-07 |
2024-02-20 |
Apellis Pharmaceuticals, Inc. |
Dosing regimens
|
|
WO2017070151A1
(en)
|
2015-10-19 |
2017-04-27 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
|
|
JP7027311B2
(ja)
|
2015-11-16 |
2022-03-01 |
オリックス ファーマシューティカルズ,インコーポレーテッド |
MyD88又はTLR3を標的とするRNA複合体を使用した加齢黄斑変性の治療
|
|
WO2017095751A1
(en)
|
2015-12-02 |
2017-06-08 |
Partikula Llc |
Compositions and methods for modulating cancer cell metabolism
|
|
US11299537B2
(en)
|
2015-12-10 |
2022-04-12 |
Fibrogen, Inc. |
Methods for treatment of motor neuron diseases
|
|
PT3391875T
(pt)
|
2015-12-18 |
2021-12-20 |
Samyang Holdings Corp |
Método para preparar micelas poliméricas contendo fármaco aniónico
|
|
BR102017001164A2
(pt)
|
2016-01-26 |
2019-03-06 |
Embrapa - Empresa Brasileira De Pesquisa Agropecuária |
Composições de rna de fita dupla para controle de diaphorina citri e métodos de uso.
|
|
US10478503B2
(en)
|
2016-01-31 |
2019-11-19 |
University Of Massachusetts |
Branched oligonucleotides
|
|
JP6944942B2
(ja)
|
2016-02-02 |
2021-10-06 |
オリックス ファーマシューティカルズ,インコーポレーテッド |
IL4Rα、TRPA1、またはF2RL1を標的とするRNA複合体を用いたアトピー性皮膚炎および喘息の治療
|
|
CN108779464B
(zh)
|
2016-02-02 |
2022-05-17 |
奥利克斯医药有限公司 |
使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病
|
|
US12447166B2
(en)
|
2016-02-25 |
2025-10-21 |
Applied Biological Laboratories, Inc. |
Compositions and methods for protecting against airborne pathogens and irritants
|
|
EP3419629A4
(en)
|
2016-02-25 |
2019-10-30 |
Applied Biological Laboratories, Inc. |
COMPOSITIONS AND PROCEDURES FOR PROTECTION AGAINST AIRBORNE PATHOGENES AND IRRITATES
|
|
WO2017147594A1
(en)
|
2016-02-26 |
2017-08-31 |
Yale University |
COMPOSITIONS AND METHODS OF USING piRNAS IN CANCER DIAGNOSTICS AND THERAPEUTICS
|
|
US20210189062A1
(en)
|
2016-03-01 |
2021-06-24 |
Alexion Pharmaceuticals, Inc. |
Biodegradable activated polymers for therapeutic delivery
|
|
WO2017152073A1
(en)
|
2016-03-04 |
2017-09-08 |
University Of Louisville Research Foundation, Inc. |
Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (vsels)
|
|
CA3011946A1
(en)
|
2016-03-07 |
2017-09-14 |
Arrowhead Pharmaceuticals, Inc. |
Targeting ligands for therapeutic compounds
|
|
JP7137474B2
(ja)
|
2016-03-15 |
2022-09-14 |
メルサナ セラピューティクス,インコーポレイティド |
NaPi2b標的化抗体-薬物コンジュゲート及びその使用方法
|
|
US20190117799A1
(en)
|
2016-04-01 |
2019-04-25 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
|
WO2017173301A1
(en)
|
2016-04-01 |
2017-10-05 |
Avidity Biosciences Llc |
Egfr nucleic acids and uses thereof
|
|
EP3436585B1
(en)
|
2016-04-01 |
2022-07-20 |
Avidity Biosciences, Inc. |
Kras nucleic acids and uses thereof
|
|
JP2019513371A
(ja)
|
2016-04-01 |
2019-05-30 |
アビディティー バイオサイエンシーズ エルエルシー |
核酸ポリペプチド組成物とその使用
|
|
WO2017173297A1
(en)
|
2016-04-01 |
2017-10-05 |
Avidity Biosciences Llc |
Beta-catenin nucleic acids and uses thereof
|
|
EP3440090B1
(en)
|
2016-04-06 |
2022-09-28 |
Ohio State Innovation Foundation |
Rna ligand-displaying exosomes for specific delivery of therapeutics to cell by rna nanotechnology
|
|
JP7049262B2
(ja)
|
2016-04-11 |
2022-04-06 |
オリックス ファーマシューティカルズ,インコーポレーテッド |
結合組織成長因子を標的とするrna複合体を用いた特発性肺胞線維症の治療
|
|
NZ747314A
(en)
*
|
2016-04-14 |
2022-07-29 |
Benitec Ip Holdings Inc |
Reagents for treatment of oculopharyngeal muscular dystrophy (opmd) and use thereof
|
|
WO2017189870A1
(en)
|
2016-04-27 |
2017-11-02 |
Massachusetts Institute Of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
|
WO2017197128A1
(en)
|
2016-05-11 |
2017-11-16 |
Yale University |
Poly(amine-co-ester) nanoparticles and methods of use thereof
|
|
KR101916652B1
(ko)
|
2016-06-29 |
2018-11-08 |
올릭스 주식회사 |
작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
|
|
AU2017290828A1
(en)
|
2016-06-30 |
2019-01-24 |
Virogin Biotech Canada Ltd |
Pseudotyped oncolytic viral delivery of therapeutic polypeptides
|
|
RU2627179C1
(ru)
*
|
2016-07-28 |
2017-08-03 |
федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации |
ТЕСТ-СИСТЕМА ДЛЯ ОПРЕДЕЛЕНИЯ РНК ИНТЕРФЕРОНА λ, ИНТЕРЛЕЙКИНА IL23 И ПРОТИВОВИРУСНОГО БЕЛКА MxA
|
|
US20190367930A1
(en)
|
2016-07-29 |
2019-12-05 |
Danmarks Tekniske Universitet |
Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides
|
|
CN110087665A
(zh)
|
2016-08-03 |
2019-08-02 |
H·李·莫菲特癌症中心与研究所公司 |
Tlr9靶向治疗
|
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
|
HUE059718T2
(hu)
|
2016-09-02 |
2022-12-28 |
Dicerna Pharmaceuticals Inc |
4'-foszfát analógok és azokat tartalmazó oligonukleotidok
|
|
SG11201901841TA
(en)
|
2016-09-02 |
2019-03-28 |
Arrowhead Pharmaceuticals Inc |
Targeting ligands
|
|
WO2018057575A1
(en)
|
2016-09-21 |
2018-03-29 |
Alnylam Pharmaceuticals, Inc |
Myostatin irna compositions and methods of use thereof
|
|
US11260134B2
(en)
|
2016-09-29 |
2022-03-01 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded nucleic acid complex having overhang
|
|
WO2018098352A2
(en)
|
2016-11-22 |
2018-05-31 |
Jun Oishi |
Targeting kras induced immune checkpoint expression
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
US11723912B2
(en)
|
2016-12-08 |
2023-08-15 |
University Of Utah Research Foundation |
Staufen1 agents and associated methods
|
|
WO2018112470A1
(en)
|
2016-12-16 |
2018-06-21 |
The Brigham And Women's Hospital, Inc. |
Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
|
|
CN110268060B
(zh)
|
2017-01-10 |
2024-07-26 |
箭头药业股份有限公司 |
α-1抗胰蛋白酶(AAT)RNAi物质、包含AAT RNAi物质的组合物和使用方法
|
|
EP3580339A4
(en)
*
|
2017-02-10 |
2020-12-23 |
Research & Business Foundation Sungkyunkwan University |
LONG DOUBLE STRAND RNA FOR RNA INTERFERENCE
|
|
DE102017103383A1
(de)
|
2017-02-20 |
2018-08-23 |
aReNA-Bio GbR (vertretungsberechtigter Gesellschafter: Dr. Heribert Bohlen, 50733 Köln) |
System und Verfahren zur Zelltyp-spezifischen Translation von RNA-Molekülen in Eukaryoten
|
|
WO2018152523A1
(en)
*
|
2017-02-20 |
2018-08-23 |
Northwestern University |
Use of trinucleotide repeat rnas to treat cancer
|
|
US20180271996A1
(en)
|
2017-02-28 |
2018-09-27 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
|
US11261441B2
(en)
|
2017-03-29 |
2022-03-01 |
Bluebird Bio, Inc. |
Vectors and compositions for treating hemoglobinopathies
|
|
IL269844B2
(en)
|
2017-04-07 |
2025-01-01 |
Apellis Pharmaceuticals Inc |
Dosage regimens and related compositions and methods
|
|
CN110945128B
(zh)
|
2017-04-14 |
2023-11-03 |
代表亚利桑那大学的亚利桑那董事会 |
用于治疗肺纤维化的组合物和方法
|
|
US11324820B2
(en)
|
2017-04-18 |
2022-05-10 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
|
|
US12544344B2
(en)
|
2017-04-19 |
2026-02-10 |
Phio Pharmaceuticals Corp. |
Topical delivery of nucleic acid compounds
|
|
WO2018209270A1
(en)
|
2017-05-11 |
2018-11-15 |
Northwestern University |
Adoptive cell therapy using spherical nucleic acids (snas)
|
|
US11788087B2
(en)
|
2017-05-25 |
2023-10-17 |
The Children's Medical Center Corporation |
BCL11A guide delivery
|
|
CA3064632A1
(en)
*
|
2017-06-20 |
2018-12-27 |
Dana-Farber Cancer Institute, Inc. |
Methods for modulating regulatory t cells, regulatory b cells, and immune responses using modulators of the april-taci interaction
|
|
JP7406793B2
(ja)
*
|
2017-06-23 |
2023-12-28 |
ユニバーシティー オブ マサチューセッツ |
2テイル自己デリバリー型siRNAおよび関連方法
|
|
TN2019000308A1
(en)
|
2017-07-06 |
2021-05-07 |
Arrowhead Pharmaceuticals Inc |
RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE
|
|
CA3069451A1
(en)
|
2017-07-13 |
2019-01-17 |
Alnylam Pharmaceuticals, Inc. |
Methods for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
|
US11110114B2
(en)
|
2017-07-17 |
2021-09-07 |
Oxford University Innovation Limited |
Dinucleotides
|
|
US11104700B2
(en)
|
2017-07-17 |
2021-08-31 |
Oxford University Innovation Limited |
Oligonucleotides
|
|
KR20240161202A
(ko)
|
2017-09-11 |
2024-11-12 |
애로우헤드 파마슈티컬스 인코포레이티드 |
아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물
|
|
BR112020005230A2
(pt)
|
2017-09-19 |
2020-09-24 |
Alnylam Pharmaceuticals, Inc. |
composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
|
|
WO2019068326A1
(en)
|
2017-10-05 |
2019-04-11 |
Université D'aix-Marseille |
INHIBITORS OF LSD1 FOR THE TREATMENT AND PREVENTION OF CARDIOMYOPATHIES
|
|
UA128786C2
(uk)
|
2017-10-20 |
2024-10-23 |
Дайсерна Фармасьютикалз, Інк |
Олігонуклеотид для лікування інфекції гепатиту в
|
|
EP3713644B1
(en)
|
2017-11-20 |
2024-08-07 |
University of Georgia Research Foundation, Inc. |
Compositions and methods for modulating hif-2a to improve muscle generation and repair
|
|
WO2019104289A1
(en)
|
2017-11-27 |
2019-05-31 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
KR102723989B1
(ko)
*
|
2017-12-01 |
2024-11-01 |
더 텍사스 에이 & 엠 유니버시티 시스템 |
엔젤만 증후군 안티센스 치료
|
|
AU2018378812B2
(en)
|
2017-12-06 |
2025-05-22 |
Avidity Biosciences, Inc. |
Compositions and methods of treating muscle atrophy and myotonic dystrophy
|
|
WO2019118938A1
(en)
|
2017-12-15 |
2019-06-20 |
Apellis Pharmaceuticals, Inc. |
Dosing regimens and related compositions and methods
|
|
EP3728281A1
(en)
|
2017-12-21 |
2020-10-28 |
Alnylam Pharmaceuticals Inc. |
Chirally-enriched double-stranded rna agents
|
|
CN111757757A
(zh)
|
2017-12-21 |
2020-10-09 |
梅尔莎纳医疗公司 |
吡咯并苯并二氮呯抗体共轭物
|
|
US10960086B2
(en)
|
2017-12-28 |
2021-03-30 |
Augusta University Research Institute, Inc. |
Aptamer compositions and methods of use thereof
|
|
EP3731850A4
(en)
|
2017-12-29 |
2021-12-01 |
Oncorus, Inc. |
ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES
|
|
US11813280B2
(en)
|
2018-01-05 |
2023-11-14 |
Dicerna Pharmaceuticals, Inc. |
Reducing beta-catenin and IDO expression to potentiate immunotherapy
|
|
KR20200109311A
(ko)
|
2018-01-16 |
2020-09-22 |
다이서나 파마수이티컬, 인크. |
Aldh2 발현을 억제하기 위한 조성물 및 방법
|
|
BR112020016170A2
(pt)
|
2018-02-09 |
2020-12-15 |
Genentech, Inc. |
Oligonucleotídeos terapêutico e antissenso, conjugado, sal farmaceuticamente aceitável, composição farmacêutica, método in vitro ou in vivo para modular a expressão de tmem106b, método para tratar ou prevenir uma doença, uso do oligonucleotídeo e uso ou método
|
|
WO2019213273A1
(en)
|
2018-05-01 |
2019-11-07 |
The Children's Medical Center Corporation |
Enhanced bcl11a rnp / crispr delivery & editing using a 3xnls-cas9
|
|
WO2019213013A1
(en)
|
2018-05-02 |
2019-11-07 |
The Children's Medical Center Corporation |
Improved bcl11a micrornas for treating hemoglobinopathies
|
|
CN112105745A
(zh)
|
2018-05-07 |
2020-12-18 |
罗氏创新中心哥本哈根有限公司 |
用于寡核苷酸治疗剂的大规模平行发现方法
|
|
WO2019215330A1
(en)
|
2018-05-10 |
2019-11-14 |
The University Of Manchester |
Methods for assessing macular degeneration
|
|
AU2019275071B2
(en)
|
2018-05-24 |
2022-12-15 |
Sirnaomics, Inc. |
Composition and methods of controllable co-coupling polypeptide nanoparticle delivery system for nucleic acid therapeutics
|
|
EP3807291A4
(en)
|
2018-06-14 |
2022-02-23 |
University of Utah Research Foundation |
STAUFEN1 REGULATORY AGENTS AND ASSOCIATED PROCEDURES
|
|
CN112534055A
(zh)
|
2018-07-13 |
2021-03-19 |
豪夫迈·罗氏有限公司 |
用于调节rtel1表达的寡核苷酸
|
|
JP7625512B2
(ja)
|
2018-08-13 |
2025-02-03 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
B型肝炎ウイルス(HBV)dsRNA物質組成物およびその使用方法
|
|
US11279930B2
(en)
|
2018-08-23 |
2022-03-22 |
University Of Massachusetts |
O-methyl rich fully stabilized oligonucleotides
|
|
WO2020051231A1
(en)
|
2018-09-04 |
2020-03-12 |
H. Lee Moffitt Cancer Center & Research Institute Inc. |
Use of delta-tocotrienol for treating cancer
|
|
WO2020051507A1
(en)
|
2018-09-06 |
2020-03-12 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
CN113365664A
(zh)
|
2018-10-29 |
2021-09-07 |
梅尔莎纳医疗公司 |
具有含肽接头的半胱氨酸工程化的抗体-药物缀合物
|
|
WO2020128816A2
(en)
|
2018-12-20 |
2020-06-25 |
Pfizer Inc. |
Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
|
|
KR20220030203A
(ko)
|
2018-12-27 |
2022-03-10 |
서나오믹스, 인크. |
암 치료를 위한 면역 체크포인트 억제제와 조합하여 전달된 siRNA를 사용하는 TGF-베타1 및 COX2의 사일런싱
|
|
CN113614232A
(zh)
|
2019-01-18 |
2021-11-05 |
马萨诸塞大学 |
动态药代动力学修饰锚
|
|
EP3908661A1
(en)
|
2019-02-12 |
2021-11-17 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for inhibiting expression of cyp27a1
|
|
BR112021018739A2
(pt)
|
2019-03-29 |
2022-05-03 |
Dicerna Pharmaceuticals Inc |
Composições e métodos para o tratamento de doenças ou distúrbios associados a kras
|
|
BR112021019793A2
(pt)
|
2019-04-04 |
2021-12-07 |
Dicerna Pharmaceuticals Inc |
Composições e métodos para inibir expressão de gene no sistema nervoso central
|
|
US11814464B2
(en)
|
2019-04-29 |
2023-11-14 |
Yale University |
Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
|
|
AU2020268798A1
(en)
|
2019-05-03 |
2021-11-04 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
|
JP7606758B2
(ja)
*
|
2019-05-22 |
2024-12-26 |
スーチョウ リボ ライフ サイエンス カンパニー、リミテッド |
核酸、薬物組成物及び複合体ならびに調製方法と使用
|
|
US20200369759A1
(en)
|
2019-05-23 |
2020-11-26 |
Fibrogen, Inc. |
Methods of treatment of muscular dystrophies
|
|
MX2021015003A
(es)
|
2019-06-06 |
2022-01-24 |
Arrowhead Pharmaceuticals Inc |
Metodos para el tratamiento de la deficiencia de alfa-1 antitripsina (aatd).
|
|
WO2020261227A1
(en)
|
2019-06-26 |
2020-12-30 |
Biorchestra Co., Ltd. |
Micellar nanoparticles and uses thereof
|
|
CA3145913A1
(en)
|
2019-07-29 |
2021-02-04 |
James Everett Dahlman |
Nanomaterials containing constrained lipids and uses thereof
|
|
KR20220047989A
(ko)
|
2019-08-09 |
2022-04-19 |
유니버시티 오브 매사추세츠 |
Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
|
|
CN114450027A
(zh)
|
2019-08-16 |
2022-05-06 |
儿童医院医疗中心 |
用cdc42特异性抑制剂治疗受试者的方法
|
|
WO2021042060A1
(en)
|
2019-08-30 |
2021-03-04 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
IL291251B1
(en)
|
2019-09-10 |
2026-02-01 |
Daiichi Sankyo Co Ltd |
Oligonucleotide-galnac conjugate for targeted delivery to the liver and method for its production
|
|
US12365894B2
(en)
|
2019-09-16 |
2025-07-22 |
University Of Massachusetts |
Branched lipid conjugates of siRNA for specific tissue delivery
|
|
AU2020358016A1
(en)
|
2019-10-02 |
2022-04-21 |
Dicerna Pharmaceuticals, Inc. |
Chemical modifications of small interfering RNA with minimal fluorine content
|
|
US11017851B1
(en)
|
2019-11-26 |
2021-05-25 |
Cypress Semiconductor Corporation |
Silicon-oxide-nitride-oxide-silicon based multi level non-volatile memory device and methods of operation thereof
|
|
MX2022007908A
(es)
|
2019-12-24 |
2022-07-21 |
Hoffmann La Roche |
Combinacion farmaceutica de un oligonucleotido terapeutico que actua sobre hbv y un agonista de tlr7 para el tratamiento de hbv.
|
|
EP4081217A1
(en)
|
2019-12-24 |
2022-11-02 |
F. Hoffmann-La Roche AG |
Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
|
|
IL294318A
(en)
|
2020-01-09 |
2022-08-01 |
Guide Therapeutics Llc |
Nanomaterials
|
|
KR20220141299A
(ko)
|
2020-01-14 |
2022-10-19 |
신테카인, 인크. |
Il2 오르토로그 및 사용 방법
|
|
US20210222128A1
(en)
|
2020-01-22 |
2021-07-22 |
Massachusetts Institute Of Technology |
Inducible tissue constructs and uses thereof
|
|
JP7735288B2
(ja)
|
2020-02-18 |
2025-09-08 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アポリポタンパク質C3(APOC3)iRNA組成物およびその使用法
|
|
US11642407B2
(en)
|
2020-02-28 |
2023-05-09 |
Massachusetts Institute Of Technology |
Identification of variable influenza residues and uses thereof
|
|
US20230287425A1
(en)
|
2020-03-18 |
2023-09-14 |
Dicerna Pharmacuticals Inc. |
Compositions and methods for inhibiting angptl3 expression
|
|
WO2021188390A1
(en)
|
2020-03-19 |
2021-09-23 |
Avidity Biosciences, Inc. |
Compositions and methods of treating facioscapulohumeral muscular dystrophy
|
|
SI4126066T1
(sl)
|
2020-03-27 |
2026-04-30 |
Avidity Biosciences, Inc. |
Sestavki in postopki zdravljenja mišične distrofije
|
|
CN115997008A
(zh)
|
2020-04-22 |
2023-04-21 |
艾欧凡斯生物治疗公司 |
协调用于患者特异性免疫疗法的细胞的制造的系统和方法
|
|
WO2021242883A1
(en)
|
2020-05-26 |
2021-12-02 |
University Of Massachusetts |
Synthetic oligonucleotides having regions of block and cluster modifications
|
|
WO2021255262A1
(en)
|
2020-06-19 |
2021-12-23 |
Sylentis Sau |
siRNA AND COMPOSITIONS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT OF VIRUS DISEASES
|
|
AU2021293780A1
(en)
|
2020-06-19 |
2023-02-02 |
Yale University |
Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery
|
|
MX2023000124A
(es)
*
|
2020-06-30 |
2023-03-08 |
Univ Court Univ Of Edinburgh |
Sistema de expresion de transgenes.
|
|
IL299826A
(en)
|
2020-07-15 |
2023-03-01 |
Cerebral Therapeutics Inc |
A medical device with a non-filtered CSF withdrawal path
|
|
US20220031633A1
(en)
|
2020-07-28 |
2022-02-03 |
Yale University |
Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
|
|
TW202221120A
(zh)
|
2020-08-04 |
2022-06-01 |
美商黛瑟納製藥公司 |
用於治療代謝症候群之組成物及方法
|
|
CA3190481A1
(en)
|
2020-08-04 |
2022-02-10 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting plp1 expression
|
|
KR20230061389A
(ko)
|
2020-08-04 |
2023-05-08 |
다이서나 파마수이티컬, 인크. |
올리고뉴클레오티드의 전신 전달
|
|
TW202221122A
(zh)
|
2020-08-05 |
2022-06-01 |
瑞士商赫孚孟拉羅股份公司 |
B型肝炎患者之寡核苷酸治療
|
|
US12435336B2
(en)
|
2020-08-05 |
2025-10-07 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting LPA expression
|
|
CN116529266A
(zh)
|
2020-08-31 |
2023-08-01 |
耶鲁大学 |
用于将核酸递送到细胞的组合物和方法
|
|
EP3964204A1
(en)
|
2020-09-08 |
2022-03-09 |
Université d'Aix-Marseille |
Lsd1 inhibitors for use in the treatment and prevention of fibrosis of tissues
|
|
EP4214515A1
(en)
|
2020-09-16 |
2023-07-26 |
Complement Therapeutics Limited |
Complementome assay
|
|
JP2023546359A
(ja)
|
2020-10-06 |
2023-11-02 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球療法によるnsclc患者の治療
|
|
KR20230107625A
(ko)
|
2020-11-13 |
2023-07-17 |
알닐람 파마슈티칼스 인코포레이티드 |
응고 인자 V(F5) iRNA 조성물 및 이의 사용 방법
|
|
WO2022115645A1
(en)
|
2020-11-25 |
2022-06-02 |
Akagera Medicines, Inc. |
Lipid nanoparticles for delivery of nucleic acids, and related methods of use
|
|
CN117295753A
(zh)
|
2020-12-04 |
2023-12-26 |
基那奥生物公司 |
用于将核酸递送到细胞的组合物和方法
|
|
EP4015634A1
(en)
|
2020-12-15 |
2022-06-22 |
Sylentis, S.A.U. |
Sirna and compositions for prophylactic and therapeutic treatment of virus diseases
|
|
EP4281080A4
(en)
|
2021-01-20 |
2025-09-24 |
Beam Therapeutics Inc |
NANOMATERIALS COMPRISING A BIODEGRADABLE ELEMENT
|
|
JP2024508896A
(ja)
|
2021-03-04 |
2024-02-28 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アンジオポエチン様3(ANGPTL3)iRNA組成物およびその使用方法
|
|
JP2024512029A
(ja)
|
2021-03-25 |
2024-03-18 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
T細胞共培養効力アッセイのための方法及び組成物、ならびに細胞療法製品との使用
|
|
WO2022211740A1
(en)
|
2021-03-31 |
2022-10-06 |
Carmine Therapeutics Pte. Ltd. |
Extracellular vesicles loaded with at least two different nucleic acids
|
|
PE20250400A1
(es)
|
2021-04-12 |
2025-02-11 |
Dicerna Pharmaceuticals Inc |
Composiciones y metodos para inhibir cetohexoquinasa
|
|
CA3209418A1
(en)
|
2021-04-14 |
2022-10-20 |
Utsav SAXENA |
Compositions and methods for modulating pnpla3 expression
|
|
WO2022223515A2
(en)
|
2021-04-19 |
2022-10-27 |
Novo Nordisk A/S |
Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression
|
|
EP4347820A1
(en)
|
2021-05-28 |
2024-04-10 |
Novo Nordisk A/S |
Compositions and methods for inhibiting mitochondria amidoxime reducing component 1 (marc1) expression
|
|
EP4347828A1
(en)
|
2021-05-29 |
2024-04-10 |
1Globe Health Institute LLC |
Short duplex dna as a novel gene silencing technology and use thereof
|
|
KR20240014532A
(ko)
|
2021-05-29 |
2024-02-01 |
1글로브 헬스 인스티튜트 엘엘씨 |
신규한 유전자 침묵 기술로서의 비대칭의 짧은 듀플렉스 dna 및 이의 용도
|
|
CN117677699A
(zh)
|
2021-06-23 |
2024-03-08 |
马萨诸塞大学 |
用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
|
|
CA3227852A1
(en)
|
2021-08-03 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof
|
|
WO2023021046A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
|
EP4392556A1
(en)
|
2021-08-25 |
2024-07-03 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting ?lpha-1 antitrypsin expression
|
|
WO2023049743A1
(en)
|
2021-09-21 |
2023-03-30 |
The Johns Hopkins University |
Dendrimer conjugates of small molecule biologics for intracellular delivery
|
|
KR20240101580A9
(ko)
|
2021-11-11 |
2025-12-10 |
에프. 호프만-라 로슈 아게 |
Hbv 치료를 위한 약학 조합물
|
|
EP4340893A1
(en)
|
2021-11-19 |
2024-03-27 |
KIST (Korea Institute of Science and Technology) |
Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell
|
|
JP2024543195A
(ja)
|
2021-12-01 |
2024-11-19 |
ディセルナ ファーマシューティカルズ インコーポレイテッド |
Apoc3発現を調節するための組成物及び方法
|
|
WO2023118546A2
(en)
|
2021-12-23 |
2023-06-29 |
Boehringer Ingelheim International Gmbh |
METHODS AND MOLECULES FOR RNA INTERFERENCE (RNAi)
|
|
US12605537B2
(en)
|
2022-02-15 |
2026-04-21 |
Biogen Ma Inc. |
Implantable medical device for use with or having recording electrode
|
|
WO2023159189A1
(en)
|
2022-02-18 |
2023-08-24 |
Yale University |
Branched poly(amine-co-ester) polymers for more efficient nucleic expression
|
|
GB202203627D0
(en)
|
2022-03-16 |
2022-04-27 |
Univ Manchester |
Agents for treating complement-related disorders
|
|
US20230302423A1
(en)
|
2022-03-28 |
2023-09-28 |
Massachusetts Institute Of Technology |
Rna scaffolded wireframe origami and methods thereof
|
|
GB202204884D0
(en)
|
2022-04-04 |
2022-05-18 |
Fondo Ricerca Medica S R I |
Sirna targeting kcna1
|
|
US20230374522A1
(en)
|
2022-04-15 |
2023-11-23 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for modulating scap activity
|
|
JP2025512401A
(ja)
|
2022-04-15 |
2025-04-17 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
特定のサイトカインの組み合わせ及び/またはAKTi処理を使用したTIL拡張プロセス
|
|
CN119173631A
(zh)
|
2022-05-12 |
2024-12-20 |
迪克纳制药公司 |
用于抑制mapt表达的组合物和方法
|
|
IL316843A
(en)
|
2022-05-13 |
2025-01-01 |
Dicerna Pharmaceuticals Inc |
Compounds and methods for inhibiting SNCA deactivation
|
|
CA3256897A1
(en)
|
2022-05-25 |
2023-11-30 |
Akagera Medicines, Inc. |
Lipid nanoparticles for the administration of nucleic acids and their methods of use
|
|
TWI868755B
(zh)
|
2022-06-24 |
2025-01-01 |
丹麥商諾佛 儂迪克股份有限公司 |
抑制跨膜絲胺酸蛋白酶6(tmprss6)表現的組成物及方法
|
|
CA3260437A1
(en)
|
2022-07-20 |
2024-01-25 |
Beam Therapeutics Inc. |
NANOMATERIALS INCLUDING TRIOLS
|
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
|
EP4602078A2
(en)
|
2022-10-11 |
2025-08-20 |
Yale University |
Compositions and methods of using cell-penetrating antibodies
|
|
TW202430637A
(zh)
|
2022-11-16 |
2024-08-01 |
美商戴瑟納製藥股份有限公司 |
Stat3靶向性寡核苷酸及其用途
|
|
EP4619524A1
(en)
|
2022-11-18 |
2025-09-24 |
Genkardia Inc. |
Methods and compositions for preventing, treating, or reversing cardiac diastolic dysfunction
|
|
JP2025539816A
(ja)
|
2022-11-21 |
2025-12-09 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の増幅のための2次元プロセス及びそれからの治療法
|
|
GB202219829D0
(en)
|
2022-12-29 |
2023-02-15 |
Ivy Farm Tech Limited |
Genetically manipulated cells
|
|
EP4649087A2
(en)
|
2023-01-11 |
2025-11-19 |
Engage Biologics Inc. |
Non-viral expression systems and methods of use thereof
|
|
WO2024175588A1
(en)
|
2023-02-21 |
2024-08-29 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
|
EP4669750A2
(en)
|
2023-02-21 |
2025-12-31 |
Vib Vzw |
SYNAPTOGYRIN-3 EXPRESSION INHIBITORS
|
|
EP4687988A2
(en)
|
2023-03-28 |
2026-02-11 |
KIST (Korea Institute of Science and Technology) |
Therapeutic compounds for inhibiting and reducing the expression of cell surface proteins
|
|
WO2024263649A1
(en)
|
2023-06-19 |
2024-12-26 |
Yale University |
Methods and compositions for enrichment and sequencing of expansion-specific rna transcripts
|
|
WO2025012473A1
(en)
|
2023-07-13 |
2025-01-16 |
Hummingbird Bioscience Pte. Ltd. |
Methods for antibody production
|
|
WO2025015189A1
(en)
|
2023-07-13 |
2025-01-16 |
Comanche Biopharma Corp. |
Formulations of nucleic acid compounds and uses thereof
|
|
TW202517141A
(zh)
|
2023-07-13 |
2025-05-01 |
新加坡商蜂鳥生物科技私人有限公司 |
生產抗體的方法
|
|
IL326017A
(en)
|
2023-07-28 |
2026-03-01 |
Novo Nordisk As |
Compositions and methods for expressing programmed death ligand receptor (PD-L1)
|
|
WO2025054459A1
(en)
|
2023-09-08 |
2025-03-13 |
Dicerna Pharmaceuticals, Inc. |
Rnai oligonucleotide conjugates
|
|
WO2025101580A1
(en)
|
2023-11-06 |
2025-05-15 |
Yale University |
Half-antibodies and other antibody fragments for attachment to degradable polymer nanoparticles
|
|
EP4560019A1
(en)
|
2023-11-22 |
2025-05-28 |
Sylentis S.A.U. |
Sirna and compositions for prophylactic and therapeutic treatment of ocular retinal conditions
|
|
EP4560020A1
(en)
|
2023-11-22 |
2025-05-28 |
Sylentis S.A.U. |
Sirna and compositions for prophylactic and therapeutic treatment of ocular retinal conditions
|
|
WO2025215354A1
(en)
|
2024-04-08 |
2025-10-16 |
Ivy Farm Technologies Limited |
Method of culturing an animal cell
|
|
EP4640682A3
(en)
|
2024-04-25 |
2025-12-31 |
The University Of Hong Kong |
AGPAT4 INHIBITOR COMPOSITIONS AND THEIR METHODS OF USE FOR TREATING CANCER
|
|
WO2025224715A1
(en)
|
2024-04-26 |
2025-10-30 |
King Abdullah Univeristy Of Science And Technology |
Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing
|
|
WO2026006832A1
(en)
|
2024-06-28 |
2026-01-02 |
University Of Connecticut |
Gene modulation for treating cancer
|
|
US20260055414A1
(en)
|
2024-08-21 |
2026-02-26 |
Novo Nordisk A/S |
Compositions and methods for inhibiting xdh expression
|