IL111660A - Oligonucleoside compounds for effecting rnaseh-mediated cleavage of a target ribonucleic acid sequence and a pharmaceutical composition containing them - Google Patents
Oligonucleoside compounds for effecting rnaseh-mediated cleavage of a target ribonucleic acid sequence and a pharmaceutical composition containing themInfo
- Publication number
- IL111660A IL111660A IL11166094A IL11166094A IL111660A IL 111660 A IL111660 A IL 111660A IL 11166094 A IL11166094 A IL 11166094A IL 11166094 A IL11166094 A IL 11166094A IL 111660 A IL111660 A IL 111660A
- Authority
- IL
- Israel
- Prior art keywords
- rnaseh
- effecting
- acid sequence
- pharmaceutical composition
- composition containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12865894A IL128658A (en) | 1993-11-16 | 1994-11-16 | Oligonucleoside compounds for effecting rnaseh mediated cleavage of a target ribonucleic acid sequence and a pharmaceutical composition containing them |
IL12865899A IL128658A0 (en) | 1993-11-16 | 1999-02-23 | Oligonucleoside compounds for effecting RNaseH mediated cleavage of a target ribonucleic acid sequence |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15401493A | 1993-11-16 | 1993-11-16 | |
US15401393A | 1993-11-16 | 1993-11-16 | |
US23377894A | 1994-04-26 | 1994-04-26 | |
US23817794A | 1994-05-04 | 1994-05-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL111660A0 IL111660A0 (en) | 1995-01-24 |
IL111660A true IL111660A (en) | 2005-05-17 |
Family
ID=27496113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11166094A IL111660A (en) | 1993-11-16 | 1994-11-16 | Oligonucleoside compounds for effecting rnaseh-mediated cleavage of a target ribonucleic acid sequence and a pharmaceutical composition containing them |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0743859A4 (en) |
JP (1) | JPH09506248A (en) |
KR (1) | KR960705589A (en) |
AU (1) | AU689182B2 (en) |
CA (1) | CA2176259A1 (en) |
IL (1) | IL111660A (en) |
NZ (1) | NZ277617A (en) |
WO (1) | WO1995013834A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996031600A1 (en) * | 1995-04-03 | 1996-10-10 | Hybridon, Inc. | Method of modulating gene expression without depleting complement |
US6509149B2 (en) * | 1995-06-06 | 2003-01-21 | Hybridon, Inc. | HPV-specific oligonucleotides |
US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US20010049436A1 (en) * | 1998-04-01 | 2001-12-06 | Wen-Qiang Zhou | Mixed-backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content |
US6277967B1 (en) | 1998-07-14 | 2001-08-21 | Isis Pharmaceuticals, Inc. | Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages |
DK1309726T4 (en) | 2000-03-30 | 2019-01-28 | Whitehead Inst Biomedical Res | RNA Sequence-Specific Mediators of RNA Interference |
ES2461765T3 (en) † | 2000-03-30 | 2014-05-21 | The Whitehead Institute For Biomedical Research | Production procedures of silenced cells or silenced organisms by means of specific RNA sequence mediators of RNA interference and uses thereof. |
CZ308053B6 (en) | 2000-12-01 | 2019-11-27 | Max Planck Gesellschaft | Isolated double-stranded RNA molecule, process for producing it and its use |
PT3222724T (en) * | 2002-08-05 | 2018-12-17 | Silence Therapeutics Gmbh | Further novel forms of interfering rna molecules |
SI3222724T1 (en) | 2002-08-05 | 2019-03-29 | Silence Therapeutics Gmbh | Further novel forms of interfering rna molecules |
US9827263B2 (en) | 2002-11-05 | 2017-11-28 | Ionis Pharmaceuticals, Inc. | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations |
US9150606B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
US9150605B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2′-modified nucleosides for use in gene modulation |
EP2742056B2 (en) * | 2011-08-11 | 2020-06-10 | Ionis Pharmaceuticals, Inc. | Selective antisense compounds and uses thereof |
WO2018051762A1 (en) * | 2016-09-14 | 2018-03-22 | レナセラピューティクス株式会社 | Antisense oligonucleotide with reduced side effects |
EP4031242A4 (en) * | 2019-09-19 | 2023-12-20 | Arnay Sciences, Llc | Compounds and methods useful for modulating gene splicing |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5212295A (en) * | 1990-01-11 | 1993-05-18 | Isis Pharmaceuticals | Monomers for preparation of oligonucleotides having chiral phosphorus linkages |
US5149797A (en) * | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
DE69233599T2 (en) * | 1991-12-24 | 2006-12-14 | Isis Pharmaceuticals, Inc., Carlsbad | Broken 2'-modified oligonucleotides |
-
1994
- 1994-11-16 WO PCT/US1994/013387 patent/WO1995013834A1/en not_active Application Discontinuation
- 1994-11-16 CA CA002176259A patent/CA2176259A1/en not_active Abandoned
- 1994-11-16 IL IL11166094A patent/IL111660A/en not_active IP Right Cessation
- 1994-11-16 NZ NZ277617A patent/NZ277617A/en unknown
- 1994-11-16 EP EP95904098A patent/EP0743859A4/en not_active Withdrawn
- 1994-11-16 JP JP7514646A patent/JPH09506248A/en active Pending
- 1994-11-16 KR KR1019960702552A patent/KR960705589A/en not_active Application Discontinuation
- 1994-11-16 AU AU12916/95A patent/AU689182B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
IL111660A0 (en) | 1995-01-24 |
CA2176259A1 (en) | 1995-05-26 |
NZ277617A (en) | 1998-01-26 |
EP0743859A1 (en) | 1996-11-27 |
WO1995013834A1 (en) | 1995-05-26 |
AU1291695A (en) | 1995-06-06 |
EP0743859A4 (en) | 1998-10-21 |
AU689182B2 (en) | 1998-03-26 |
KR960705589A (en) | 1996-11-08 |
JPH09506248A (en) | 1997-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9K | Patent not in force due to non-payment of renewal fees |