ATE554185T1 - Verfahren und konstrukte zur bewertung von rnai- zielen und effektormolekülen - Google Patents
Verfahren und konstrukte zur bewertung von rnai- zielen und effektormolekülenInfo
- Publication number
- ATE554185T1 ATE554185T1 AT04714072T AT04714072T ATE554185T1 AT E554185 T1 ATE554185 T1 AT E554185T1 AT 04714072 T AT04714072 T AT 04714072T AT 04714072 T AT04714072 T AT 04714072T AT E554185 T1 ATE554185 T1 AT E554185T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- constructs
- evaluation
- effector molecules
- rnai
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108091030071 RNAI Proteins 0.000 title 1
- 239000012636 effector Substances 0.000 title 1
- 238000011156 evaluation Methods 0.000 title 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 3
- 230000009368 gene silencing by RNA Effects 0.000 abstract 3
- 230000032361 posttranscriptional gene silencing Effects 0.000 abstract 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45107003P | 2003-02-27 | 2003-02-27 | |
| PCT/US2004/005065 WO2004076629A2 (en) | 2003-02-27 | 2004-02-24 | METHODS AND CONSTRUCTS FOR EVALUATION OF RNAi TARGETS AND EFFECTOR MOLECULES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE554185T1 true ATE554185T1 (de) | 2012-05-15 |
Family
ID=32927699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04714072T ATE554185T1 (de) | 2003-02-27 | 2004-02-24 | Verfahren und konstrukte zur bewertung von rnai- zielen und effektormolekülen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060263764A1 (de) |
| EP (1) | EP1597351B1 (de) |
| AT (1) | ATE554185T1 (de) |
| AU (1) | AU2004214954A1 (de) |
| CA (1) | CA2517235A1 (de) |
| WO (1) | WO2004076629A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077563A1 (en) * | 2003-08-29 | 2007-04-05 | Takara Bio Inc. | Method of searching for functional nucleotide molecule |
| WO2005038054A1 (en) * | 2003-10-20 | 2005-04-28 | Zicai Liang | METHOD OF MEASURING THE EFFICACY OF siRNA MOLECULES |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| EP2514758B2 (de) | 2004-03-15 | 2021-06-23 | City of Hope | Verfahren und Zusammensetzungen zur spezifischen Inhibition der Genexpression durch doppelsträngige RNA |
| EP2169072A1 (de) | 2004-08-23 | 2010-03-31 | Alnylam Pharmaceuticals, Inc | Expressionskonstrukte mit mehreren RNA-Polymerase-III-Promotoren |
| CA2824308A1 (en) | 2004-09-24 | 2006-04-06 | Alnylam Pharmaceuticals, Inc. | Targeting opposite strand replication intermediates of single-stranded viruses by rnai |
| ATE507293T1 (de) | 2004-12-22 | 2011-05-15 | Alnylam Pharmaceuticals Inc | Zum gen-silencing geeignete konservierte hbv- und hcv-sequenzen |
| JP2009516525A (ja) * | 2005-11-22 | 2009-04-23 | プラント リサーチ インターナショナル ベー． フェー． | 複合的核酸検出法 |
| DK2548438T3 (en) | 2006-11-08 | 2015-10-19 | Veritas Bio LLC | IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL |
| WO2008112127A2 (en) * | 2007-03-08 | 2008-09-18 | Switchgear Genomics | Functional arrays for high throughput characterization of regulatory elements in untranslated regions of genes |
| KR101142209B1 (ko) | 2007-09-22 | 2012-05-04 | 재단법인서울대학교산학협력재단 | 섭취 ＲＮＡｉ를 이용한 꼬마선충에서 두 유전자의동시발현 억제방법 |
| CN101173294B (zh) * | 2007-10-12 | 2011-01-26 | 中山大学 | 一种基因微链载体及其构建方法和应用 |
| US8815779B2 (en) | 2009-09-16 | 2014-08-26 | SwitchGear Genomics, Inc. | Transcription biomarkers of biological responses and methods |
| UA118951C2 (uk) | 2011-04-21 | 2019-04-10 | Айоніс Фармасьютікалз, Інк. | Модулювання експресії вірусу гепатиту b (hbv) |
| US10307226B2 (en) | 2013-03-14 | 2019-06-04 | National Dentex, Llc | Bone foundation guide and method of use |
| US10278789B2 (en) | 2013-03-14 | 2019-05-07 | National Dentex, Llc | Bone foundation guide system and method |
| US10398530B2 (en) | 2013-03-14 | 2019-09-03 | National Dentex, Llc | Bone foundation guide system and method |
| EP3265107B1 (de) | 2015-03-02 | 2024-10-02 | 180 Therapeutics LP | Verfahren zur behandlung einer lokalisierten fibrotischen störung mit einem tnf-rezeptor-2-antagonisten |
| EP3364908A1 (de) | 2015-10-23 | 2018-08-29 | Daniel R. Llop | Knochenfundamentführungssystem und -verfahren |
| WO2017155823A1 (en) | 2016-03-05 | 2017-09-14 | National Dentex, Llc | Bone foundation guide system and method |
| WO2018102397A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| KR102234135B1 (ko) * | 2019-10-30 | 2021-03-31 | 서울대학교산학협력단 | GFP 유전자의 발현을 억제하는 dsRNA 및 이의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5738985A (en) * | 1993-04-02 | 1998-04-14 | Ribogene, Inc. | Method for selective inactivation of viral replication |
| US6013447A (en) | 1997-11-21 | 2000-01-11 | Innovir Laboratories, Inc. | Random intracellular method for obtaining optimally active nucleic acid molecules |
| US20020002278A1 (en) * | 1999-11-05 | 2002-01-03 | Timothy W. Nilsen | Random intracellular method for obtaining optimally active nucleic acid molecules |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| CA2369944A1 (en) * | 2001-01-31 | 2002-07-31 | Nucleonics Inc. | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| WO2002090498A2 (en) * | 2001-05-04 | 2002-11-14 | Health Research, Inc. | A high throughput assay for identification of gene expression modifiers |
-
2004
- 2004-02-24 CA CA002517235A patent/CA2517235A1/en not_active Abandoned
- 2004-02-24 EP EP04714072A patent/EP1597351B1/de not_active Expired - Lifetime
- 2004-02-24 US US10/547,256 patent/US20060263764A1/en not_active Abandoned
- 2004-02-24 AU AU2004214954A patent/AU2004214954A1/en not_active Abandoned
- 2004-02-24 WO PCT/US2004/005065 patent/WO2004076629A2/en not_active Ceased
- 2004-02-24 AT AT04714072T patent/ATE554185T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004076629A2 (en) | 2004-09-10 |
| EP1597351B1 (de) | 2012-04-18 |
| US20060263764A1 (en) | 2006-11-23 |
| AU2004214954A1 (en) | 2004-09-10 |
| CA2517235A1 (en) | 2004-09-10 |
| WO2004076629A3 (en) | 2005-10-27 |
| EP1597351A2 (de) | 2005-11-23 |
| EP1597351A4 (de) | 2006-06-14 |
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