JPH08500481A
(ja)
*
|
1992-05-11 |
1996-01-23 |
リボザイム・ファーマシューティカルズ・インコーポレーテッド |
ウイルスの複製を阻害するための方法および薬剤
|
US20030206887A1
(en)
*
|
1992-05-14 |
2003-11-06 |
David Morrissey |
RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
|
US5639647A
(en)
*
|
1994-03-29 |
1997-06-17 |
Ribozyme Pharmaceuticals, Inc. |
2'-deoxy-2'alkylnucleotide containing nucleic acid
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20040219569A1
(en)
*
|
1999-07-06 |
2004-11-04 |
Fruma Yehiely |
Gene identification method
|
US20110003879A1
(en)
*
|
2005-03-11 |
2011-01-06 |
Vincent Mark D |
Antisense oligonucleotides targeted to the coding region of thymidylate synthase and uses thereof
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
BRPI9908967B1
(pt)
|
1998-03-20 |
2017-05-30 |
Benitec Australia Ltd |
processos para reprimir, retardar ou de outro modo reduzir a expressão de um gene alvo em uma célula de planta
|
EP1071753A2
(en)
*
|
1998-04-20 |
2001-01-31 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
CA2361201A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
US7601494B2
(en)
|
1999-03-17 |
2009-10-13 |
The University Of North Carolina At Chapel Hill |
Method of screening candidate compounds for susceptibility to biliary excretion
|
PT1176195E
(pt)
|
1999-04-09 |
2013-07-18 |
Kyowa Hakko Kirin Co Ltd |
Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
|
US6656698B1
(en)
*
|
1999-06-30 |
2003-12-02 |
Millennium Pharmaceuticals, Inc. |
12832, a novel human kinase-like molecule and uses thereof
|
US6423885B1
(en)
|
1999-08-13 |
2002-07-23 |
Commonwealth Scientific And Industrial Research Organization (Csiro) |
Methods for obtaining modified phenotypes in plant cells
|
US8128922B2
(en)
|
1999-10-20 |
2012-03-06 |
Johns Hopkins University |
Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
|
GB9925459D0
(en)
*
|
1999-10-27 |
1999-12-29 |
Plant Bioscience Ltd |
Gene silencing
|
DE10100586C1
(de)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
US7829693B2
(en)
*
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
DE10160151A1
(de)
*
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
US7179796B2
(en)
*
|
2000-01-18 |
2007-02-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
US20050032733A1
(en)
*
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
US8202979B2
(en)
*
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
US20080039414A1
(en)
*
|
2002-02-20 |
2008-02-14 |
Sima Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
WO2002081628A2
(en)
*
|
2001-04-05 |
2002-10-17 |
Ribozyme Pharmaceuticals, Incorporated |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
|
US8202846B2
(en)
|
2000-03-16 |
2012-06-19 |
Cold Spring Harbor Laboratory |
Methods and compositions for RNA interference
|
JP2003526367A
(ja)
|
2000-03-16 |
2003-09-09 |
ジェネティカ インコーポレイテッド |
Rna干渉の方法とrna干渉組成物
|
US20030084471A1
(en)
*
|
2000-03-16 |
2003-05-01 |
David Beach |
Methods and compositions for RNA interference
|
EP2345742B1
(en)
*
|
2000-03-30 |
2014-06-11 |
The Whitehead Institute for Biomedical Research |
RNA sequence-specific mediators of RNA interference
|
DK2361981T4
(da)
*
|
2000-03-30 |
2019-05-13 |
The Whitehead Institute For Biomedical Res |
Rna-sekvensspecifikke mediatorer af rna-interferens
|
US20080242627A1
(en)
*
|
2000-08-02 |
2008-10-02 |
University Of Southern California |
Novel rna interference methods using dna-rna duplex constructs
|
US7662791B2
(en)
*
|
2000-08-02 |
2010-02-16 |
University Of Southern California |
Gene silencing using mRNA-cDNA hybrids
|
JP5087201B2
(ja)
*
|
2000-08-03 |
2012-12-05 |
ジョンズ・ホプキンス・ユニバーシティ |
抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン
|
US20080032942A1
(en)
|
2000-08-30 |
2008-02-07 |
Mcswiggen James |
RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
|
US20030190635A1
(en)
*
|
2002-02-20 |
2003-10-09 |
Mcswiggen James A. |
RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
|
US7691821B2
(en)
|
2001-09-19 |
2010-04-06 |
University Of South Florida |
Inhibition of SHIP to enhance stem cell harvest and transplantation
|
US20020165192A1
(en)
*
|
2000-09-19 |
2002-11-07 |
Kerr William G. |
Control of NK cell function and survival by modulation of ship activity
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
ES2728168T3
(es)
*
|
2000-12-01 |
2019-10-22 |
Max Planck Gesellschaft |
Moléculas pequeñas de ARN que median en la interferencia de ARN
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
US20020132257A1
(en)
*
|
2001-01-31 |
2002-09-19 |
Tony Giordano |
Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
|
US20050191618A1
(en)
*
|
2001-05-18 |
2005-09-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
|
US20050014172A1
(en)
|
2002-02-20 |
2005-01-20 |
Ivan Richards |
RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA)
|
US20050196767A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)
|
US20050153914A1
(en)
*
|
2001-05-18 |
2005-07-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA)
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050159379A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc |
RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA)
|
US20040219671A1
(en)
*
|
2002-02-20 |
2004-11-04 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of parkinson disease using short interfering nucleic acid (siNA)
|
US20080188430A1
(en)
*
|
2001-05-18 |
2008-08-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
US20050054596A1
(en)
*
|
2001-11-30 |
2005-03-10 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050196781A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of STAT3 gene expression using short interfering nucleic acid (siNA)
|
WO2003070743A1
(en)
*
|
2002-02-20 |
2003-08-28 |
Ribozyme Pharmaceuticals, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF G72 AND D-AMINO ACID OXIDASE (DAAO) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20050239731A1
(en)
*
|
2001-05-18 |
2005-10-27 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)
|
US20050233997A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
US20030124513A1
(en)
*
|
2001-05-29 |
2003-07-03 |
Mcswiggen James |
Enzymatic nucleic acid treatment of diseases or conditions related to levels of HIV
|
WO2005078097A2
(en)
*
|
2004-02-10 |
2005-08-25 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING MULTIFUNCTIONAL SHORT INTERFERING NUCLEIC ACID (Multifunctional siNA)
|
US20050261219A1
(en)
*
|
2001-05-18 |
2005-11-24 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
US20050196765A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
|
US20050233996A1
(en)
*
|
2002-02-20 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
|
US20050187174A1
(en)
*
|
2001-05-18 |
2005-08-25 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
|
US20090299045A1
(en)
*
|
2001-05-18 |
2009-12-03 |
Sirna Therapeutics, Inc. |
RNA Interference Mediated Inhibition Of Interleukin and Interleukin Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
US20070042983A1
(en)
*
|
2001-05-18 |
2007-02-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
WO2005014811A2
(en)
*
|
2003-08-08 |
2005-02-17 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF XIAP GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20030175950A1
(en)
*
|
2001-05-29 |
2003-09-18 |
Mcswiggen James A. |
RNA interference mediated inhibition of HIV gene expression using short interfering RNA
|
US7517864B2
(en)
|
2001-05-18 |
2009-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050159378A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
|
US20050176663A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sima Therapeutics, Inc. |
RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA)
|
US20050209180A1
(en)
*
|
2001-05-18 |
2005-09-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
US20040198682A1
(en)
*
|
2001-11-30 |
2004-10-07 |
Mcswiggen James |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA)
|
US20060142225A1
(en)
*
|
2001-05-18 |
2006-06-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)
|
US20060148743A1
(en)
*
|
2001-05-18 |
2006-07-06 |
Vasant Jadhav |
RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA)
|
US20050282188A1
(en)
*
|
2001-05-18 |
2005-12-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050048529A1
(en)
*
|
2002-02-20 |
2005-03-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
|
US20050176666A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA)
|
US20040019001A1
(en)
*
|
2002-02-20 |
2004-01-29 |
Mcswiggen James A. |
RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
|
US20050176024A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA)
|
US20050143333A1
(en)
*
|
2001-05-18 |
2005-06-30 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
US20070270579A1
(en)
*
|
2001-05-18 |
2007-11-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050164967A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
|
US20050124569A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
|
US20080161256A1
(en)
*
|
2001-05-18 |
2008-07-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050182007A1
(en)
*
|
2001-05-18 |
2005-08-18 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
US20070093437A1
(en)
*
|
2001-05-18 |
2007-04-26 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina)
|
US20050136436A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of G72 and D-amino acid oxidase (DAAO) gene expression using short interfering nucleic acid (siNA)
|
US20050203040A1
(en)
*
|
2001-05-18 |
2005-09-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
|
US20050222066A1
(en)
*
|
2001-05-18 |
2005-10-06 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050119212A1
(en)
*
|
2001-05-18 |
2005-06-02 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA)
|
US20050159380A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA)
|
US20050164968A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA)
|
US20060211642A1
(en)
*
|
2001-05-18 |
2006-09-21 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
US20050233344A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
|
US20050124566A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
|
WO2003070197A2
(en)
*
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20050176025A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
|
US20050164224A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
|
US20050176664A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA)
|
US20050159382A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
|
US20050267058A1
(en)
*
|
2001-05-18 |
2005-12-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA)
|
US20050158735A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA)
|
US7109165B2
(en)
*
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
US20050079610A1
(en)
*
|
2001-05-18 |
2005-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
|
US20050137155A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA)
|
US20050256068A1
(en)
*
|
2001-05-18 |
2005-11-17 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
|
US20050288242A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA)
|
US9994853B2
(en)
|
2001-05-18 |
2018-06-12 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
US20050159381A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA)
|
US20050287128A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
|
EP1627061B1
(en)
*
|
2001-05-18 |
2009-08-12 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8008472B2
(en)
|
2001-05-29 |
2011-08-30 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
|
EP2270024B1
(en)
|
2001-06-21 |
2018-10-24 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
US20050019915A1
(en)
*
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
EP1412371B1
(en)
|
2001-07-12 |
2016-02-24 |
University of Massachusetts |
IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
|
DE10133858A1
(de)
*
|
2001-07-12 |
2003-02-06 |
Aventis Pharma Gmbh |
Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
|
ES2546829T3
(es)
|
2001-07-23 |
2015-09-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Métodos y composiciones para la inhibición mediada por iARN de la expresión génica en mamíferos
|
US10590418B2
(en)
*
|
2001-07-23 |
2020-03-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for RNAi mediated inhibition of gene expression in mammals
|
US20090247606A1
(en)
*
|
2001-08-28 |
2009-10-01 |
Sirna Therapeutics, Inc. |
RNA Interference Mediated Inhibition of Adenosine A1 Receptor (ADORA1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
US20030198627A1
(en)
*
|
2001-09-01 |
2003-10-23 |
Gert-Jan Arts |
siRNA knockout assay method and constructs
|
US7745418B2
(en)
|
2001-10-12 |
2010-06-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting viral replication
|
DE10163098B4
(de)
*
|
2001-10-12 |
2005-06-02 |
Alnylam Europe Ag |
Verfahren zur Hemmung der Replikation von Viren
|
WO2003035870A1
(de)
*
|
2001-10-26 |
2003-05-01 |
Ribopharma Ag |
Medikament zur behandlung eines pankreaskarzinoms
|
CN1604783A
(zh)
*
|
2001-10-26 |
2005-04-06 |
里伯药品公司 |
通过rna干扰治疗纤维化疾病的药物
|
DE10230996A1
(de)
*
|
2001-10-26 |
2003-07-17 |
Ribopharma Ag |
Medikament zur Behandlung eines Pankreaskarzinoms
|
JP2005506087A
(ja)
*
|
2001-10-26 |
2005-03-03 |
リボファーマ アーゲー |
プラス鎖rnaウイルスによる感染症を処置するための2本鎖リボ核酸の使用
|
IL161733A0
(en)
*
|
2001-11-02 |
2005-11-20 |
Insert Therapeutics Inc |
Methods and compositions for therapeutic use of rna interference
|
US20040063654A1
(en)
*
|
2001-11-02 |
2004-04-01 |
Davis Mark E. |
Methods and compositions for therapeutic use of RNA interference
|
AU2002348163A1
(en)
*
|
2001-11-02 |
2003-05-19 |
Intradigm Corporation |
Therapeutic methods for nucleic acid delivery vehicles
|
KR20100087400A
(ko)
*
|
2001-11-21 |
2010-08-04 |
가오루 사이고 |
유전자 발현 억제 방법
|
US20050075304A1
(en)
*
|
2001-11-30 |
2005-04-07 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20040138163A1
(en)
*
|
2002-05-29 |
2004-07-15 |
Mcswiggen James |
RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20070203333A1
(en)
*
|
2001-11-30 |
2007-08-30 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US7294504B1
(en)
|
2001-12-27 |
2007-11-13 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Methods and compositions for DNA mediated gene silencing
|
ATE402999T1
(de)
*
|
2002-01-17 |
2008-08-15 |
Univ British Columbia |
Bispezifische antisense oligonukleotide die igfbp-2 und igfbp-5 inhibieren und deren verwendung
|
DE10202419A1
(de)
|
2002-01-22 |
2003-08-07 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens
|
GB0201477D0
(en)
*
|
2002-01-23 |
2002-03-13 |
Novartis Forschungsstiftung |
Methods of obtaining isoform specific expression in mammalian cells
|
US20030166282A1
(en)
*
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
US20060009409A1
(en)
*
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
EP2213292B2
(en)
*
|
2002-02-01 |
2016-06-22 |
Life Technologies Corporation |
Double-stranded oligonucleotides
|
US20050096289A1
(en)
*
|
2002-02-07 |
2005-05-05 |
Hans Prydz |
Methods and compositions for modulating tissue factor
|
AU2003223172A1
(en)
*
|
2002-02-12 |
2003-09-04 |
Quark Biotech, Inc. |
Use of the axl receptor for diagnosis and treatment of renal disease
|
US20050202428A1
(en)
*
|
2002-02-13 |
2005-09-15 |
Axordia Limited |
Pluripotential stem cells
|
DE60323340D1
(de)
|
2002-02-14 |
2008-10-16 |
Hope City |
Verfahren zur herstellung interferierender rna-moleküle in säugetierzellen und therapeutische anwendungen solcher moleküle
|
JP2005517433A
(ja)
*
|
2002-02-20 |
2005-06-16 |
サーナ・セラピューティクス・インコーポレイテッド |
短干渉核酸(siNA)を用いるTNFおよびTNFレセプタースーパーファミリー遺伝子発現のRNA干渉媒介性阻害
|
US7667029B2
(en)
|
2002-02-20 |
2010-02-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
|
US20090253773A1
(en)
|
2002-02-20 |
2009-10-08 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8258288B2
(en)
|
2002-02-20 |
2012-09-04 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA)
|
US7910724B2
(en)
|
2002-02-20 |
2011-03-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
|
US7683165B2
(en)
|
2002-02-20 |
2010-03-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
WO2003106476A1
(en)
*
|
2002-02-20 |
2003-12-24 |
Sirna Therapeutics, Inc |
Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity
|
US7897757B2
(en)
|
2002-02-20 |
2011-03-01 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
|
US20090099117A1
(en)
|
2002-02-20 |
2009-04-16 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MYOSTATIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7928219B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA)
|
US7928220B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)
|
US7893248B2
(en)
|
2002-02-20 |
2011-02-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
|
US20090093439A1
(en)
*
|
2002-02-20 |
2009-04-09 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20090137509A1
(en)
*
|
2002-02-20 |
2009-05-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF PROLIFERATION CELL NUCLEAR ANTIGEN (PCNA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7935812B2
(en)
|
2002-02-20 |
2011-05-03 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
US7897753B2
(en)
|
2002-02-20 |
2011-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA)
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
AU2003219818A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Ribozyme Pharmaceuticals, Incorporated |
RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20100240730A1
(en)
*
|
2002-02-20 |
2010-09-23 |
Merck Sharp And Dohme Corp. |
RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
|
AU2003213005A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc |
RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
US20090192105A1
(en)
|
2002-02-20 |
2009-07-30 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA)
|
US20090233983A1
(en)
*
|
2002-02-20 |
2009-09-17 |
Sirna Therapeutics Inc. |
RNA Interference Mediated Inhibition of Protein Tyrosine Phosphatase-1B (PTP-1B) Gene Expression Using Short Interfering RNA
|
AU2003211058A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED TARGET DISCOVERY AND TARGET VALIDATION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7662952B2
(en)
*
|
2002-02-20 |
2010-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)
|
US7897752B2
(en)
|
2002-02-20 |
2011-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
|
US7683166B2
(en)
|
2002-02-20 |
2010-03-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
US8013143B2
(en)
|
2002-02-20 |
2011-09-06 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US7928218B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
|
US20090253774A1
(en)
|
2002-02-20 |
2009-10-08 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF PLATELET DERIVED GROWTH FACTOR (PDGF) AND PLATELET DERIVED GROWTH FACTOR RECEPTOR (PDGFR) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20090247613A1
(en)
*
|
2002-02-20 |
2009-10-01 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8232383B2
(en)
*
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US8067575B2
(en)
|
2002-02-20 |
2011-11-29 |
Merck, Sharp & Dohme Corp. |
RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
|
US7667030B2
(en)
|
2002-02-20 |
2010-02-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
US7795422B2
(en)
|
2002-02-20 |
2010-09-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
US7700760B2
(en)
|
2002-02-20 |
2010-04-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
|
US20050096284A1
(en)
*
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
US20090306182A1
(en)
*
|
2002-02-20 |
2009-12-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MAP KINASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7691999B2
(en)
|
2002-02-20 |
2010-04-06 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA)
|
CA2457528C
(en)
*
|
2002-02-20 |
2011-07-12 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of hepatitis c virus (hcv) gene expression using short interfering nucleic acid (sina)
|
US7678897B2
(en)
|
2002-02-20 |
2010-03-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
|
US20060111312A1
(en)
*
|
2002-02-22 |
2006-05-25 |
The John Hopkins University |
Antigene locks and therapeutic uses thereof
|
US7332276B2
(en)
*
|
2002-03-01 |
2008-02-19 |
Celltech R&D, Inc. |
Methods to increase or decrease bone density
|
EP1572923A4
(en)
*
|
2002-03-06 |
2007-10-31 |
Rigel Pharmaceuticals Inc |
NEW METHOD FOR THE INTRODUCTION AND INTRA-CELLULAR SYNTHESIS OF SIRNA MOLECULES
|
US7274703B2
(en)
*
|
2002-03-11 |
2007-09-25 |
3Com Corporation |
Stackable network units with resiliency facility
|
JP2005521393A
(ja)
*
|
2002-03-20 |
2005-07-21 |
マサチューセッツ インスティテュート オブ テクノロジー |
Hiv治療
|
US7357928B2
(en)
|
2002-04-08 |
2008-04-15 |
University Of Louisville Research Foundation, Inc. |
Method for the diagnosis and prognosis of malignant diseases
|
MXPA04010282A
(es)
*
|
2002-04-18 |
2005-08-18 |
Acuity Pharmaceuticals Inc |
Medios y metodos para la inhibicion especifica de genes en celulas y tejido de cns y/u ojo.
|
PT1504126E
(pt)
|
2002-05-03 |
2014-06-02 |
Univ Duke |
Um método para regular a expressão génica
|
US7399586B2
(en)
|
2002-05-23 |
2008-07-15 |
Ceptyr, Inc. |
Modulation of biological signal transduction by RNA interference
|
US7199107B2
(en)
*
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
AU2003237686A1
(en)
*
|
2002-05-24 |
2003-12-12 |
Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Rna interference mediating small rna molecules
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
US20040033602A1
(en)
*
|
2002-06-12 |
2004-02-19 |
Ambion, Inc. |
Methods and compositions relating to polypeptides with RNase III domains that mediate RNA interference
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
US20030235916A1
(en)
*
|
2002-06-14 |
2003-12-25 |
Monahan Sean D. |
Novel methods for the delivery of polynucleotides to cells
|
US20100009856A1
(en)
*
|
2002-06-21 |
2010-01-14 |
Sinogenomax Sompany LTD. |
Randomized dna libraries and double-stranded rna libraries, use and method of production thereof
|
JP2005537028A
(ja)
*
|
2002-06-26 |
2005-12-08 |
ザ ペン ステート リサーチ ファウンデーション |
ヒト乳頭腫ウイルス感染症を治療する方法及び材料
|
DK1519714T3
(da)
|
2002-06-28 |
2011-01-31 |
Protiva Biotherapeutics Inc |
Fremgangsmåde og apparat til fremstilling af liposomer
|
US8101348B2
(en)
*
|
2002-07-10 |
2012-01-24 |
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. |
RNA-interference by single-stranded RNA molecules
|
US7148342B2
(en)
*
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
US20040241854A1
(en)
|
2002-08-05 |
2004-12-02 |
Davidson Beverly L. |
siRNA-mediated gene silencing
|
AU2015264957B2
(en)
*
|
2002-08-05 |
2017-10-26 |
Silence Therapeutics Gmbh |
Further novel forms of interfering rna molecules
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
AU2012216354B2
(en)
*
|
2002-08-05 |
2016-01-14 |
Silence Therapeutics Gmbh |
Further novel forms of interfering RNA molecules
|
ES2389024T3
(es)
|
2002-08-05 |
2012-10-22 |
Silence Therapeutics Aktiengesellschaft |
Moléculas de RNA interferentes de extremos romos
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
MXPA05001355A
(es)
|
2002-08-05 |
2005-09-30 |
Atugen Ag |
Formas nuevas adicionales de moleculas de arn de interferencia.
|
ES2627779T5
(es)
*
|
2002-08-05 |
2021-05-04 |
Silence Therapeutics Gmbh |
Nuevas formas adicionales de moléculas de ARN de interferencia
|
US20060293256A1
(en)
*
|
2002-08-06 |
2006-12-28 |
Masateru Yamada |
Remedy or preventive for kidney disease and method of diagnosing kidney disease
|
WO2004013310A2
(en)
*
|
2002-08-06 |
2004-02-12 |
Intradigm Corporation |
Methods of down regulating target gene expression in vivo by introduction of interfering rna
|
WO2004014933A1
(en)
*
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
BRPI0313733A8
(pt)
|
2002-08-14 |
2016-08-16 |
Atugen Ag |
Uso da proteína n beta cinase
|
KR101212512B1
(ko)
*
|
2002-08-21 |
2012-12-26 |
더 유니버시티 오브 브리티쉬 콜롬비아 |
암-관련 단백질을 표적으로 하는 알엔에이아이 프로브
|
US7923547B2
(en)
*
|
2002-09-05 |
2011-04-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US20060287269A1
(en)
*
|
2002-09-09 |
2006-12-21 |
The Regents Of The University Of California |
Short interfering nucleic acid hybrids and methods thereof
|
US20080260744A1
(en)
|
2002-09-09 |
2008-10-23 |
Omeros Corporation |
G protein coupled receptors and uses thereof
|
US20040138119A1
(en)
*
|
2002-09-18 |
2004-07-15 |
Ingo Tamm |
Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis
|
US20060257380A1
(en)
*
|
2002-09-19 |
2006-11-16 |
Inst.Nat. De La Sante Et De La Recherche MED |
Use of sirnas for gene silencing in antigen presenting cells
|
AU2003282877B9
(en)
*
|
2002-09-25 |
2011-05-12 |
University Of Massachusetts |
In Vivo gene silencing by chemically modified and stable siRNA
|
US20060160759A1
(en)
*
|
2002-09-28 |
2006-07-20 |
Jianzhu Chen |
Influenza therapeutic
|
US20040242518A1
(en)
*
|
2002-09-28 |
2004-12-02 |
Massachusetts Institute Of Technology |
Influenza therapeutic
|
JP2006512906A
(ja)
*
|
2002-09-28 |
2006-04-20 |
マサチューセッツ インスティチュート オブ テクノロジー |
インフルエンザ治療剤
|
US20060240425A1
(en)
*
|
2002-09-30 |
2006-10-26 |
Oncotherapy Science, Inc |
Genes and polypeptides relating to myeloid leukemia
|
US7422853B1
(en)
*
|
2002-10-04 |
2008-09-09 |
Myriad Genetics, Inc. |
RNA interference using a universal target
|
NZ540779A
(en)
*
|
2002-11-01 |
2008-05-30 |
Univ Pennsylvania |
Compositions and methods for siRNA inhibition of HIF-1 alpha
|
US7892793B2
(en)
|
2002-11-04 |
2011-02-22 |
University Of Massachusetts |
Allele-specific RNA interference
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
EP1562971B1
(en)
|
2002-11-05 |
2014-02-12 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
WO2004044132A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
WO2004043978A2
(en)
*
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
DE10322662A1
(de)
*
|
2002-11-06 |
2004-10-07 |
Grünenthal GmbH |
Wirksame und stabile DNA-Enzyme
|
US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
US7977471B2
(en)
*
|
2002-11-14 |
2011-07-12 |
Dharmacon, Inc. |
siRNA targeting TNFα
|
US8163896B1
(en)
|
2002-11-14 |
2012-04-24 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
US9719092B2
(en)
|
2002-11-14 |
2017-08-01 |
Thermo Fisher Scientific Inc. |
RNAi targeting CNTD2
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
US7619081B2
(en)
|
2002-11-14 |
2009-11-17 |
Dharmacon, Inc. |
siRNA targeting coatomer protein complex, subunit beta 2 (COPB2)
|
US9879266B2
(en)
|
2002-11-14 |
2018-01-30 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
US7592442B2
(en)
|
2002-11-14 |
2009-09-22 |
Dharmacon, Inc. |
siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2)
|
US20090005548A1
(en)
*
|
2002-11-14 |
2009-01-01 |
Dharmacon, Inc. |
siRNA targeting nuclear receptor interacting protein 1 (NRIP1)
|
US9771586B2
(en)
|
2002-11-14 |
2017-09-26 |
Thermo Fisher Scientific Inc. |
RNAi targeting ZNF205
|
US7655785B1
(en)
|
2002-11-14 |
2010-02-02 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
US10920226B2
(en)
*
|
2002-11-14 |
2021-02-16 |
Thermo Fisher Scientific Inc. |
siRNA targeting LDHA
|
US7951935B2
(en)
|
2002-11-14 |
2011-05-31 |
Dharmacon, Inc. |
siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)
|
US20100113307A1
(en)
*
|
2002-11-14 |
2010-05-06 |
Dharmacon, Inc. |
siRNA targeting vascular endothelial growth factor (VEGF)
|
US10011836B2
(en)
|
2002-11-14 |
2018-07-03 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
US8198427B1
(en)
|
2002-11-14 |
2012-06-12 |
Dharmacon, Inc. |
SiRNA targeting catenin, beta-1 (CTNNB1)
|
US20090227780A1
(en)
*
|
2002-11-14 |
2009-09-10 |
Dharmacon, Inc. |
siRNA targeting connexin 43
|
US7691998B2
(en)
*
|
2002-11-14 |
2010-04-06 |
Dharmacon, Inc. |
siRNA targeting nucleoporin 62kDa (Nup62)
|
US7612196B2
(en)
*
|
2002-11-14 |
2009-11-03 |
Dharmacon, Inc. |
siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
|
US7781575B2
(en)
|
2002-11-14 |
2010-08-24 |
Dharmacon, Inc. |
siRNA targeting tumor protein 53 (p53)
|
US9839649B2
(en)
|
2002-11-14 |
2017-12-12 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
AU2003295600A1
(en)
|
2002-11-14 |
2004-06-15 |
Dharmacon, Inc. |
Functional and hyperfunctional sirna
|
US9719094B2
(en)
|
2002-11-14 |
2017-08-01 |
Thermo Fisher Scientific Inc. |
RNAi targeting SEC61G
|
US20080268457A1
(en)
*
|
2002-11-14 |
2008-10-30 |
Dharmacon, Inc. |
siRNA targeting forkhead box P3 (FOXP3)
|
US7635770B2
(en)
|
2002-11-14 |
2009-12-22 |
Dharmacon, Inc. |
siRNA targeting protein kinase N-3 (PKN-3)
|
US7927793B2
(en)
|
2002-11-18 |
2011-04-19 |
The United States Of America As Represented By The Department Of Health And Human Services |
Cell lines and host nucleic acid sequences related to infectious disease
|
US7064337B2
(en)
|
2002-11-19 |
2006-06-20 |
The Regents Of The University Of California |
Radiation detection system for portable gamma-ray spectroscopy
|
DE10254214A1
(de)
*
|
2002-11-20 |
2004-06-09 |
Beiersdorf Ag |
Oligoribonukleotide zur Behandlung von degenerativen Hauterscheinungen durch RNA-Interferenz
|
JP4526228B2
(ja)
*
|
2002-11-22 |
2010-08-18 |
隆 森田 |
RNAiによる新規治療法および治療剤
|
WO2004047764A2
(en)
*
|
2002-11-22 |
2004-06-10 |
University Of Massachusetts |
Modulation of hiv replication by rna interference
|
AU2003284624B2
(en)
*
|
2002-11-22 |
2010-06-03 |
Bio-Think Tank Co. Ltd |
Method for searching target base sequence of RNA interference, method for designing base sequence of polynucleotide for causing RNA interference, method for producing double-stranded polynucleotide, method for inhibiting gene expression, base sequence processing apparatus, program for running base sequence processing method on computer, recording medium, and base sequence processing system
|
US7605249B2
(en)
|
2002-11-26 |
2009-10-20 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
AU2003298724B2
(en)
*
|
2002-11-26 |
2009-12-24 |
University Of Massachusetts |
Delivery of siRNAs
|
US20130130231A1
(en)
|
2002-11-26 |
2013-05-23 |
Isaac Bentwich |
Bioinformatically detectable group of novel viral regulatory genes and uses thereof
|
US7618948B2
(en)
|
2002-11-26 |
2009-11-17 |
Medtronic, Inc. |
Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
|
US7790867B2
(en)
|
2002-12-05 |
2010-09-07 |
Rosetta Genomics Inc. |
Vaccinia virus-related nucleic acids and microRNA
|
US7829694B2
(en)
|
2002-11-26 |
2010-11-09 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
US7696334B1
(en)
|
2002-12-05 |
2010-04-13 |
Rosetta Genomics, Ltd. |
Bioinformatically detectable human herpesvirus 5 regulatory gene
|
CN1301263C
(zh)
*
|
2002-12-18 |
2007-02-21 |
北京昭衍新药研究中心 |
一组抗hiv感染及防治艾滋病的核苷酸序列及其应用
|
US9498530B2
(en)
|
2002-12-24 |
2016-11-22 |
Rinat Neuroscience Corp. |
Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
|
SI2263692T1
(sl)
|
2002-12-24 |
2020-10-30 |
Rinat Neuroscience Corp. |
Anti-NGF protitelesa in postopki, v katerih se le-ta uporabljajo
|
WO2004063331A2
(en)
*
|
2003-01-03 |
2004-07-29 |
Gencia Corporation |
SiRNA MEDIATED POST-TRANSRIPTIONAL GENE SILENCING OF GENES INVOLVED IN ALOPECIA
|
ATE477337T1
(de)
|
2003-01-16 |
2010-08-15 |
Univ Pennsylvania |
Zusammensetzungen und verfahren zur sirna-hemmung von icam-1
|
US7629323B2
(en)
*
|
2003-01-21 |
2009-12-08 |
Northwestern University |
Manipulation of neuronal ion channels
|
US20040147027A1
(en)
*
|
2003-01-28 |
2004-07-29 |
Troy Carol M. |
Complex for facilitating delivery of dsRNA into a cell and uses thereof
|
US20060178297A1
(en)
*
|
2003-01-28 |
2006-08-10 |
Troy Carol M |
Systems and methods for silencing expression of a gene in a cell and uses thereof
|
US7732591B2
(en)
|
2003-11-25 |
2010-06-08 |
Medtronic, Inc. |
Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
|
US7994149B2
(en)
|
2003-02-03 |
2011-08-09 |
Medtronic, Inc. |
Method for treatment of Huntington's disease through intracranial delivery of sirna
|
WO2004071430A2
(en)
*
|
2003-02-05 |
2004-08-26 |
University Of Massachusetts |
RNAi TARGETING OF VIRUSES
|
FR2850971B1
(fr)
*
|
2003-02-10 |
2006-08-11 |
Aventis Pharma Sa |
Oligonucleotide antisens inhibant l'expression de la proteine ob-rgrp et procede de detection de composes modifiant l'interaction entre la famille de la proteine ob-rgrp et le recepteur de la leptine
|
US20070104688A1
(en)
|
2003-02-13 |
2007-05-10 |
City Of Hope |
Small interfering RNA mediated transcriptional gene silencing in mammalian cells
|
US20040162235A1
(en)
*
|
2003-02-18 |
2004-08-19 |
Trubetskoy Vladimir S. |
Delivery of siRNA to cells using polyampholytes
|
DE602004030535D1
(de)
|
2003-02-19 |
2011-01-27 |
Rinat Neuroscience Corp |
Verfahren zur behandlung von schmerzen durch verabreichung eines nervenwachstumsfaktor-antagonisten und eines nsaid und diese enthaltende zusammensetzung
|
WO2005017127A2
(en)
*
|
2003-02-21 |
2005-02-24 |
The Penn State Research Foundation |
Rna interference compositions and methods
|
US8796235B2
(en)
*
|
2003-02-21 |
2014-08-05 |
University Of South Florida |
Methods for attenuating dengue virus infection
|
CA2517259A1
(en)
*
|
2003-02-27 |
2004-09-10 |
National Institute Of Advanced Industrial Science And Technology |
Induction of methylation of cpg sequences by dsrnas in mammalian cells
|
ATE554185T1
(de)
*
|
2003-02-27 |
2012-05-15 |
Alnylam Pharmaceuticals Inc |
Verfahren und konstrukte zur bewertung von rnai- zielen und effektormolekülen
|
AU2004217437B2
(en)
*
|
2003-03-05 |
2009-11-19 |
Senesco Technologies, Inc. |
Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
|
WO2004078941A2
(en)
*
|
2003-03-06 |
2004-09-16 |
Oligo Engine, Inc. |
Modulation of gene expression using dna-rna hybrids
|
EP2216407B1
(en)
|
2003-03-07 |
2016-01-13 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
JP4762889B2
(ja)
*
|
2003-03-12 |
2011-08-31 |
バスジーン セラピューティクス,インコーポレイテッド |
血管形成及び腫瘍成長を阻止するための核酸化合物
|
DE602004023279D1
(de)
|
2003-03-21 |
2009-11-05 |
Santaris Pharma As |
Analoga kurzer interferierender rna (sirna)
|
ATE536408T1
(de)
*
|
2003-04-02 |
2011-12-15 |
Dharmacon Inc |
Modifizierte polynukleotide zur verwendung bei rna-interferenz
|
WO2004090105A2
(en)
*
|
2003-04-02 |
2004-10-21 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
US20040198640A1
(en)
*
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
CA2521464C
(en)
|
2003-04-09 |
2013-02-05 |
Alnylam Pharmaceuticals, Inc. |
Irna conjugates
|
EP1631669A2
(en)
*
|
2003-04-09 |
2006-03-08 |
Biodelivery Sciences International, Inc. |
Cochleate compositions directed against expression of proteins
|
US20070270360A1
(en)
*
|
2003-04-15 |
2007-11-22 |
Sirna Therapeutics, Inc. |
Rna Interference Mediated Inhibition of Severe Acute Respiratory Syndrome (Sars) Gene Expression Using Short Interfering Nucleic Acid
|
AU2004232964B2
(en)
|
2003-04-17 |
2011-09-22 |
Alnylam Pharmaceuticals, Inc. |
Protected monomers
|
US8796436B2
(en)
|
2003-04-17 |
2014-08-05 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
US8017762B2
(en)
|
2003-04-17 |
2011-09-13 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
US7723509B2
(en)
|
2003-04-17 |
2010-05-25 |
Alnylam Pharmaceuticals |
IRNA agents with biocleavable tethers
|
EP1620544B1
(en)
|
2003-04-17 |
2018-09-19 |
Alnylam Pharmaceuticals Inc. |
MODIFIED iRNA AGENTS
|
CA2522730A1
(en)
*
|
2003-04-18 |
2004-11-04 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for sirna inhibition of angiopoietin 1 and 2 and their receptor tie2
|
WO2005032595A2
(en)
*
|
2003-04-23 |
2005-04-14 |
Georgetown University |
Methods and compositions for the inhibition of stat5 in prostate cancer cells
|
EP1644048B1
(en)
*
|
2003-05-05 |
2015-04-29 |
Johns Hopkins University |
Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
|
EP1623032A2
(en)
|
2003-05-09 |
2006-02-08 |
University of Pittsburgh of the Commonwealth System of Higher Education |
Small interfering rna libraries and methods of synthesis and use
|
JP4884224B2
(ja)
|
2003-05-09 |
2012-02-29 |
ディアデクサス インコーポレーテッド |
Ovr110抗体組成物および使用方法
|
AU2003241409A1
(en)
*
|
2003-05-12 |
2005-01-21 |
Potomac Pharmaceuticals, Inc. |
Gene expression suppression agents
|
WO2004104199A2
(en)
*
|
2003-05-15 |
2004-12-02 |
Oligo Engine, Inc. |
Modulation of gene expression using dna-dna hybrids
|
CA2525619A1
(en)
*
|
2003-05-16 |
2005-03-03 |
Rosetta Inpharmatics, Llc |
Methods and compositions for rna interference
|
US20070243570A1
(en)
|
2003-05-19 |
2007-10-18 |
Genecare Research Institute Co., Ltd |
Apoptosis Inducer for Cancer Cell
|
EP1640452A4
(en)
|
2003-05-30 |
2009-12-23 |
Nippon Shinyaku Co Ltd |
OLIGOBICATENARY RNA INHIBITING BCL-2 EXPRESSION AND MEDICINAL COMPOSITION CONTAINING THE SAME
|
WO2004105774A1
(ja)
*
|
2003-05-30 |
2004-12-09 |
Nippon Shinyaku Co., Ltd. |
オリゴ核酸担持複合体、当該複合体を含有する医薬組成物
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
PL1633767T3
(pl)
*
|
2003-06-02 |
2019-07-31 |
University Of Massachusetts |
Sposoby i kompozycje do kontrolowania wydajności wyciszania rna
|
WO2005001043A2
(en)
|
2003-06-02 |
2005-01-06 |
University Of Massachusetts |
METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi
|
US20050019918A1
(en)
*
|
2003-06-03 |
2005-01-27 |
Hidetoshi Sumimoto |
Treatment of cancer by inhibiting BRAF expression
|
BRPI0410886A
(pt)
*
|
2003-06-03 |
2006-07-04 |
Isis Pharmaceuticals Inc |
composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único
|
US7595306B2
(en)
*
|
2003-06-09 |
2009-09-29 |
Alnylam Pharmaceuticals Inc |
Method of treating neurodegenerative disease
|
US8575327B2
(en)
|
2003-06-12 |
2013-11-05 |
Alnylam Pharmaceuticals, Inc. |
Conserved HBV and HCV sequences useful for gene silencing
|
EP1633770B1
(en)
*
|
2003-06-13 |
2015-04-29 |
Alnylam Europe AG |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
EP1486564A1
(de)
*
|
2003-06-13 |
2004-12-15 |
Ribopharma AG |
SiRNA mit erhöhter Stabilität in Serum
|
EP1636342A4
(en)
*
|
2003-06-20 |
2008-10-08 |
Isis Pharmaceuticals Inc |
OLIGOMERIC COMPOUNDS FOR GENE MODULATION
|
WO2004113496A2
(en)
*
|
2003-06-20 |
2004-12-29 |
Isis Pharmaceuticals, Inc. |
Double stranded compositions comprising a 3’-endo modified strand for use in gene modulation
|
WO2005007623A2
(en)
*
|
2003-07-03 |
2005-01-27 |
The Trustees Of The University Of Pennsylvania |
Inhibition of syk kinase expression
|
US20050256071A1
(en)
*
|
2003-07-15 |
2005-11-17 |
California Institute Of Technology |
Inhibitor nucleic acids
|
WO2006001810A2
(en)
*
|
2003-07-15 |
2006-01-05 |
California Institute Of Technology |
Improved inhibitor nucleic acids
|
NZ544637A
(en)
*
|
2003-07-16 |
2010-04-30 |
Protiva Biotherapeutics Inc |
Lipid encapsulated interfering RNA
|
US20050079614A1
(en)
*
|
2003-07-21 |
2005-04-14 |
Reinhart Brenda J. |
RNAs able to modulate chromatin silencing
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
NZ545544A
(en)
*
|
2003-08-13 |
2009-04-30 |
Univ Illinois |
Silencing of TGF-beta receptor type II expression by sirna
|
US7888497B2
(en)
|
2003-08-13 |
2011-02-15 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
WO2005035759A2
(en)
*
|
2003-08-20 |
2005-04-21 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HYPOXIA INDUCIBLE FACTOR 1 (HIF1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20050136437A1
(en)
*
|
2003-08-25 |
2005-06-23 |
Nastech Pharmaceutical Company Inc. |
Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
|
KR20110007263A
(ko)
|
2003-08-28 |
2011-01-21 |
노파르티스 아게 |
블런트-말단 및 3'-변형체를 갖는 간섭 rna 이중나선
|
US8501705B2
(en)
*
|
2003-09-11 |
2013-08-06 |
The Board Of Regents Of The University Of Texas System |
Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
|
EP2821085B1
(en)
*
|
2003-09-12 |
2020-04-29 |
University of Massachusetts |
Rna interference for the treatment of gain-of-function disorders
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
CA2539181A1
(en)
|
2003-09-18 |
2005-03-31 |
Isis Pharmaceuticals, Inc. |
Modulation of eif4e expression
|
CA2539651A1
(en)
*
|
2003-09-22 |
2005-04-07 |
Rosetta Inpharmatics Llc |
Synthetic lethal screen using rna interference
|
WO2005033310A1
(de)
*
|
2003-10-01 |
2005-04-14 |
Grünenthal GmbH |
Pim-1-spezifische dsrna-verbindungen
|
JP2007517498A
(ja)
*
|
2003-10-07 |
2007-07-05 |
アステラス製薬株式会社 |
骨形態形成タンパク質(bmp)2a及びその使用
|
WO2005035769A2
(en)
|
2003-10-09 |
2005-04-21 |
E. I. Du Pont De Nemours And Company |
Gene silencing by using micro-rna molecules
|
WO2005045032A2
(en)
*
|
2003-10-20 |
2005-05-19 |
Sima Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF EARLY GROWTH RESPONSE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
EP1694838A2
(en)
*
|
2003-10-23 |
2006-08-30 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GPRA AND AAA1 GENE EXPRESSION USING SHORT NUCLEIC ACID (siNA)
|
WO2005044981A2
(en)
*
|
2003-10-23 |
2005-05-19 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
CN1926551B
(zh)
|
2003-10-27 |
2010-06-16 |
罗斯塔生化科技有限责任公司 |
用于基因沉默的siRNA的设计方法
|
US8227434B1
(en)
|
2003-11-04 |
2012-07-24 |
H. Lee Moffitt Cancer Center & Research Institute, Inc. |
Materials and methods for treating oncological disorders
|
WO2005047504A1
(en)
*
|
2003-11-07 |
2005-05-26 |
The Board Of Trustees Of The University Of Illinois |
Induction of cellular senescence by cdk4 disruption for tumor suppression and regression
|
EP1697515A4
(en)
*
|
2003-11-12 |
2008-02-06 |
Austin Research Inst |
CONJUGATE DNA-EXCIPIENT
|
JP2005168485A
(ja)
*
|
2003-11-20 |
2005-06-30 |
Tsutomu Suzuki |
siRNAの設計方法
|
US7763592B1
(en)
*
|
2003-11-20 |
2010-07-27 |
University Of South Florida |
SHIP-deficiency to increase megakaryocyte progenitor production
|
US7807646B1
(en)
|
2003-11-20 |
2010-10-05 |
University Of South Florida |
SHIP-deficiency to increase megakaryocyte progenitor production
|
US20050208658A1
(en)
*
|
2003-11-21 |
2005-09-22 |
The University Of Maryland |
RNA interference mediated inhibition of 11beta hydroxysteriod dehydrogenase-1 (11beta HSD-1) gene expression
|
US20100145038A1
(en)
*
|
2003-11-24 |
2010-06-10 |
Merck & Co., Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
JP2007513611A
(ja)
*
|
2003-11-26 |
2007-05-31 |
ザ クイーンズ ユニヴァーシティ オブ ベルファスト |
癌治療
|
JP5654722B2
(ja)
|
2003-11-26 |
2015-01-14 |
ユニバーシティ オブ マサチューセッツ |
短鎖rna機能の配列特異的阻害法
|
EP1689414A4
(en)
|
2003-12-04 |
2009-04-08 |
Univ South Florida Res Foundat |
POLYNUCLEOTIDES FOR REDUCING GENE EXPRESSION OF THE RESPIRATORY SYNCYTIAL VIRUS
|
CA2548972A1
(en)
*
|
2003-12-12 |
2005-06-30 |
Wisconsin Alumni Research Foundation |
Treatment of mammals by sirna delivery into mammalian nerve cells
|
WO2005068630A1
(ja)
*
|
2003-12-16 |
2005-07-28 |
National Institute Of Advanced Industrial Science And Technology |
干渉用二重鎖rna
|
US20060134787A1
(en)
*
|
2004-12-22 |
2006-06-22 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
|
AU2004308484A1
(en)
*
|
2003-12-23 |
2005-07-14 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for combined therapy of disease
|
JP4767019B2
(ja)
*
|
2004-01-16 |
2011-09-07 |
武田薬品工業株式会社 |
動脈硬化の予防・治療用医薬
|
DK1713912T3
(da)
*
|
2004-01-30 |
2013-12-16 |
Santaris Pharma As |
Modificerede Korte Interfererende RNA (Modificerede siRNA)
|
EP2330111A3
(en)
|
2004-01-30 |
2011-08-17 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
|
US20070269889A1
(en)
*
|
2004-02-06 |
2007-11-22 |
Dharmacon, Inc. |
Stabilized siRNAs as transfection controls and silencing reagents
|
WO2005078848A2
(en)
|
2004-02-11 |
2005-08-25 |
University Of Tennessee Research Foundation |
Inhibition of tumor growth and invasion by anti-matrix metalloproteinase dnazymes
|
WO2005079533A2
(en)
*
|
2004-02-17 |
2005-09-01 |
University Of Massachusetts |
Methods and compositions for mediating gene silencing
|
WO2005079532A2
(en)
*
|
2004-02-17 |
2005-09-01 |
University Of Massachusetts |
Methods and compositions for enhancing risc activity in vitro and in vivo
|
EP1566202A1
(en)
*
|
2004-02-23 |
2005-08-24 |
Sahltech I Göteborg AB |
Use of resistin antagonists in the treatment of rheumatoid arthritis
|
CA2556729A1
(en)
*
|
2004-02-23 |
2005-09-09 |
Genzyme Corporation |
Muc1 antagonist enhancement of death receptor ligand-induced apoptosis
|
EP1723177A2
(en)
|
2004-02-24 |
2006-11-22 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Rab9a, rab11a, and modulators thereof related to infectious disease
|
US7691823B2
(en)
*
|
2004-03-05 |
2010-04-06 |
University Of Massachusetts |
RIP140 regulation of glucose transport
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
US20050202075A1
(en)
*
|
2004-03-12 |
2005-09-15 |
Pardridge William M. |
Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers
|
EP2899278A1
(en)
|
2004-03-12 |
2015-07-29 |
Alnylam Pharmaceuticals Inc. |
iRNA agents targeting VEGF
|
US20070265220A1
(en)
*
|
2004-03-15 |
2007-11-15 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
US8084599B2
(en)
*
|
2004-03-15 |
2011-12-27 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
US20050208090A1
(en)
*
|
2004-03-18 |
2005-09-22 |
Medtronic, Inc. |
Methods and systems for treatment of neurological diseases of the central nervous system
|
US7851452B2
(en)
*
|
2004-03-22 |
2010-12-14 |
The Trustees Of The University Of Pennsylvania |
Methods of use of bcl-6-derived nucleotides to induce apoptosis
|
US20050272682A1
(en)
*
|
2004-03-22 |
2005-12-08 |
Evers Bernard M |
SiRNA targeting PI3K signal transduction pathway and siRNA-based therapy
|
WO2005095622A2
(en)
*
|
2004-03-26 |
2005-10-13 |
Van Andel Research Institute |
c-met siRNA ADENOVIRUS VECTORS INHIBIT CANCER CELL GROWTH, INVASION AND TUMORIGENICITY
|
DK1730280T3
(en)
*
|
2004-03-26 |
2019-02-04 |
Curis Inc |
RNA interference modulators for hedgehog signaling and applications thereof
|
JP2005312428A
(ja)
*
|
2004-03-31 |
2005-11-10 |
Keio Gijuku |
Skp−2発現抑制を利用した癌の治療
|
WO2005095647A1
(ja)
*
|
2004-03-31 |
2005-10-13 |
Takara Bio Inc. |
siRNAのスクリーニング方法
|
KR101147147B1
(ko)
*
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
JP2007531794A
(ja)
|
2004-04-05 |
2007-11-08 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
|
EP2520652B1
(en)
|
2004-04-09 |
2015-06-10 |
Genecare Research Institute Co., Ltd |
Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associates genes
|
US20060078902A1
(en)
*
|
2004-04-15 |
2006-04-13 |
Michaeline Bunting |
Method and compositions for RNA interference
|
EP2145957B1
(en)
*
|
2004-04-20 |
2013-12-25 |
Marina Biotech, Inc. |
Compositions for enhancing delivery of double-stranded RNA to regulate gene expression in mammalian cells
|
AU2005238034A1
(en)
|
2004-04-23 |
2005-11-10 |
The Trustees Of Columbia University In The City Of New York |
Inhibition of hairless protein mRNA
|
CA2562685C
(en)
|
2004-04-27 |
2013-09-17 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
|
US8029815B2
(en)
|
2004-04-28 |
2011-10-04 |
Elford Howard L |
Methods for treating or preventing restenosis and other vascular proliferative disorders
|
JP4584987B2
(ja)
|
2004-04-30 |
2010-11-24 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
C5修飾ピリミジンを含むオリゴヌクレオチド
|
US20060040882A1
(en)
*
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
US20110117088A1
(en)
*
|
2004-05-12 |
2011-05-19 |
Simon Michael R |
Composition and method for introduction of rna interference sequences into targeted cells and tissues
|
US20060030003A1
(en)
*
|
2004-05-12 |
2006-02-09 |
Simon Michael R |
Composition and method for introduction of RNA interference sequences into targeted cells and tissues
|
US20050260214A1
(en)
*
|
2004-05-12 |
2005-11-24 |
Simon Michael R |
Composition and method for introduction of RNA interference sequences into targeted cells and tissues
|
US7605250B2
(en)
*
|
2004-05-12 |
2009-10-20 |
Dharmacon, Inc. |
siRNA targeting cAMP-specific phosphodiesterase 4D
|
CA2566519C
(en)
|
2004-05-14 |
2020-04-21 |
Rosetta Genomics Ltd. |
Micrornas and uses thereof
|
WO2005110464A2
(en)
*
|
2004-05-14 |
2005-11-24 |
Oregon Health & Science University |
Irx5 inhibition as treatment for hyperproliferative disorders
|
US7687616B1
(en)
|
2004-05-14 |
2010-03-30 |
Rosetta Genomics Ltd |
Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
|
US10508277B2
(en)
|
2004-05-24 |
2019-12-17 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
WO2006033679A2
(en)
*
|
2004-05-25 |
2006-03-30 |
Chimeracore, Inc. |
Self-assembling nanoparticle drug delivery system
|
US7795419B2
(en)
|
2004-05-26 |
2010-09-14 |
Rosetta Genomics Ltd. |
Viral and viral associated miRNAs and uses thereof
|
EP2290074B1
(en)
|
2004-05-28 |
2014-12-17 |
Asuragen, Inc. |
Methods and compositions involving microRNA
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
EP1602926A1
(en)
|
2004-06-04 |
2005-12-07 |
University of Geneva |
Novel means and methods for the treatment of hearing loss and phantom hearing
|
ATE536418T1
(de)
*
|
2004-06-07 |
2011-12-15 |
Protiva Biotherapeutics Inc |
Lipidverkapselte interferenz-rna
|
EP1781593B1
(en)
*
|
2004-06-07 |
2011-12-14 |
Protiva Biotherapeutics Inc. |
Cationic lipids and methods of use
|
US20060008907A1
(en)
*
|
2004-06-09 |
2006-01-12 |
The Curators Of The University Of Missouri |
Control of gene expression via light activated RNA interference
|
US20090215860A1
(en)
*
|
2004-06-17 |
2009-08-27 |
The Regents Of The University Of California |
Compositions and methods for regulating gene transcription
|
US20060051815A1
(en)
*
|
2004-06-25 |
2006-03-09 |
The J. David Gladstone Institutes |
Methods of treating smooth muscle cell disorders
|
US7615618B2
(en)
|
2004-06-30 |
2009-11-10 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a non-phosphate backbone linkage
|
CA2572439A1
(en)
*
|
2004-07-02 |
2006-01-12 |
Protiva Biotherapeutics, Inc. |
Immunostimulatory sirna molecules and uses therefor
|
CA2576293C
(en)
*
|
2004-07-12 |
2016-10-04 |
Nicola J. Mabjeesh |
Agents capable of downregulating an msf-a-dependent hif-1alpha and use thereof in cancer treatment
|
AU2005330703A1
(en)
*
|
2004-07-19 |
2006-10-26 |
Baylor College Of Medicine |
Modulation of cytokine signaling regulators and applications for immunotherapy
|
CA2574086A1
(en)
*
|
2004-07-21 |
2006-02-23 |
Medtronic, Inc. |
Medical devices and methods for reducing localized fibrosis
|
EP1773993A2
(en)
*
|
2004-07-21 |
2007-04-18 |
Medtronic, Inc. |
METHODS FOR REDUCING OR PREVENTING LOCALIZED FIBROSIS USING SiRNA
|
WO2006093526A2
(en)
|
2004-07-21 |
2006-09-08 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a modified or non-natural nucleobase
|
EP2484780A1
(en)
|
2004-07-23 |
2012-08-08 |
The University of North Carolina At Chapel Hill |
Methods and materials for determining pain sensibility and predicting and treating related disorders
|
US7632932B2
(en)
|
2004-08-04 |
2009-12-15 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
|
WO2006020557A2
(en)
*
|
2004-08-10 |
2006-02-23 |
Immusol, Inc. |
Methods of using or identifying agents that inhibit cancer growth
|
AU2005272816B2
(en)
|
2004-08-10 |
2011-08-11 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides
|
WO2006110161A2
(en)
*
|
2004-08-13 |
2006-10-19 |
University Of Delaware |
Method for identification and quantification of short or small rna molecules
|
CA2577423C
(en)
|
2004-08-16 |
2012-11-06 |
Quark Biotech, Inc. |
Therapeutic uses of inhibitors of rtp801
|
WO2006021817A2
(en)
*
|
2004-08-23 |
2006-03-02 |
Sylentis S.A.U. |
Treatment of eye disorders characterized by an elevated introacular pressure by sirnas
|
US20070021366A1
(en)
*
|
2004-11-19 |
2007-01-25 |
Srivastava Satish K |
Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
|
WO2006024880A2
(en)
*
|
2004-08-31 |
2006-03-09 |
Sylentis S.A.U. |
Methods and compositions to inhibit p2x7 receptor expression
|
US7323310B2
(en)
|
2004-08-31 |
2008-01-29 |
Qiagen North American Holdings, Inc. |
Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
US20090170794A1
(en)
*
|
2004-09-10 |
2009-07-02 |
Somagenics Inc. |
Small interfering rnas that efficiently inhibit viral expression and methods of use thereof
|
FI20041204A0
(fi)
|
2004-09-16 |
2004-09-16 |
Riikka Lund |
Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi
|
US8569374B2
(en)
*
|
2004-09-16 |
2013-10-29 |
The Trustees Of The University Of Pennsylvania |
NADPH oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities
|
WO2006036916A2
(en)
|
2004-09-24 |
2006-04-06 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of apob and uses thereof
|
DK1799269T3
(en)
|
2004-09-28 |
2016-10-03 |
Quark Pharmaceuticals Inc |
Oligoribonucleotides and methods of use thereof for treating alopecia, acute renal failure, and other diseases
|
WO2006039343A2
(en)
*
|
2004-09-30 |
2006-04-13 |
Centocor, Inc. |
Emmprin antagonists and uses thereof
|
CA2584960A1
(en)
|
2004-10-21 |
2006-05-04 |
Charles L. Niblett |
Methods and materials for conferring resistance to pests and pathogens of plants
|
US7943755B2
(en)
*
|
2004-10-22 |
2011-05-17 |
Neuregenix Limited |
Neuron regeneration
|
US7592322B2
(en)
*
|
2004-10-22 |
2009-09-22 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
|
US20060110440A1
(en)
*
|
2004-10-22 |
2006-05-25 |
Kiminobu Sugaya |
Method and system for biasing cellular development
|
US7790878B2
(en)
*
|
2004-10-22 |
2010-09-07 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
|
JP2008520191A
(ja)
|
2004-10-27 |
2008-06-19 |
バンダービルト・ユニバーシティ |
感染に関与する哺乳動物遺伝子
|
EP2371954A1
(en)
*
|
2004-10-27 |
2011-10-05 |
Schering Corporation |
Compositions and methods for short interfering nucleic acid inhibition of NAv1.8
|
EP1804771A2
(en)
*
|
2004-10-28 |
2007-07-11 |
Idexx Laboratories, Inc. |
Compositions for controlled delivery of pharmaceutically active compounds
|
US20060094676A1
(en)
*
|
2004-10-29 |
2006-05-04 |
Ronit Lahav |
Compositions and methods for treating cancer using compositions comprising an inhibitor of endothelin receptor activity
|
WO2007001448A2
(en)
|
2004-11-04 |
2007-01-04 |
Massachusetts Institute Of Technology |
Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
|
EP2287303B1
(en)
|
2004-11-12 |
2014-07-02 |
Asuragen, Inc. |
Methods and compositions involving miRNA and miRNA inhibitor molecules
|
JP2008520583A
(ja)
*
|
2004-11-15 |
2008-06-19 |
マウント シナイ スクール オブ メディスン オブ ニューヨーク ユニバーシティー |
Wnt自己分泌シグナル伝達を改変するための組成物および方法
|
US20060105052A1
(en)
*
|
2004-11-15 |
2006-05-18 |
Acar Havva Y |
Cationic nanoparticle having an inorganic core
|
WO2006053430A1
(en)
*
|
2004-11-17 |
2006-05-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of apolipoprotein b
|
EP2189469B1
(en)
*
|
2004-11-18 |
2015-09-16 |
The Board Of Trustees Of The University Of Illinois |
Multicistronic siRNA constructs to inhibit tumors
|
KR101330229B1
(ko)
*
|
2004-11-19 |
2013-11-15 |
가부시키가이샤 진케어켄큐쇼 |
암세포 특이적 세포증식 억제제
|
US7923206B2
(en)
*
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Method of determining a cellular response to a biological agent
|
US7923207B2
(en)
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing pools
|
US7935811B2
(en)
|
2004-11-22 |
2011-05-03 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing compositions
|
EP1814597A4
(en)
*
|
2004-11-24 |
2009-04-22 |
Alnylam Pharmaceuticals Inc |
RNAI MODULATION OF BCR-ABL FUSION GENE AND APPLICATIONS THEREOF
|
WO2006060454A2
(en)
*
|
2004-12-02 |
2006-06-08 |
B-Bridge International, Inc. |
Methods of designing small interfering rnas, antisense polynucleotides, and other hybridizing polynucleotides
|
US20060165667A1
(en)
*
|
2004-12-03 |
2006-07-27 |
Case Western Reserve University |
Novel methods, compositions and devices for inducing neovascularization
|
WO2006066158A2
(en)
*
|
2004-12-14 |
2006-06-22 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of mll-af4 and uses thereof
|
ATE479740T1
(de)
|
2004-12-17 |
2010-09-15 |
Beth Israel Hospital |
Zusammensetzungen für bakteriell vermitteltes gen-silencing sowie verfahren zur verwendung davon
|
GB0427916D0
(en)
*
|
2004-12-21 |
2005-01-19 |
Astrazeneca Ab |
Method
|
TWI386225B
(zh)
|
2004-12-23 |
2013-02-21 |
Alcon Inc |
用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術
|
US20060142228A1
(en)
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
EP2992902A1
(en)
|
2004-12-27 |
2016-03-09 |
Silence Therapeutics GmbH |
Lipid complexes coated with peg and their uses
|
EP1838875A4
(en)
*
|
2004-12-30 |
2010-08-25 |
Todd M Hauser |
COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING SELF-PROTECTED OLIGONUCLEOTIDES
|
WO2006073970A2
(en)
*
|
2005-01-06 |
2006-07-13 |
The Johns Hopkins University |
Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines
|
DE602006013275D1
(de)
|
2005-01-07 |
2010-05-12 |
Diadexus Inc |
Ovr110-antikörperzusammensetzungen und verwendungsverfahren dafür
|
EP2487243A3
(en)
*
|
2005-01-07 |
2013-08-28 |
Alnylam Pharmaceuticals Inc. |
RNAI modulation of RSV and therapeutic uses thereof
|
EP1841464B1
(en)
*
|
2005-01-24 |
2012-06-27 |
Alnylam Pharmaceuticals Inc. |
Rnai modulation of the nogo-l or nogo-r gene and uses thereof
|
EP1846026A4
(en)
*
|
2005-01-26 |
2008-07-02 |
Univ Johns Hopkins |
ANTICANCER DNA VACCINE USING PLASMID CODING ANTIGEN AND CALRETICULIN SUCH AS MUTANT ONCOPROTEINS
|
TW200639252A
(en)
*
|
2005-02-01 |
2006-11-16 |
Alcon Inc |
RNAi-mediated inhibition of ocular hypertension targets
|
WO2006085700A2
(en)
*
|
2005-02-14 |
2006-08-17 |
Hvc Stragetic Research Institute, Inc. |
Pharmaceutical agents for preventing metastasis of cancer
|
US7745389B2
(en)
|
2005-02-14 |
2010-06-29 |
University Of Iowa Research Foundation |
Methods for treatment of age-related macular degeneration
|
US8859749B2
(en)
|
2005-03-08 |
2014-10-14 |
Qiagen Gmbh |
Modified short interfering RNA
|
JP2008533050A
(ja)
|
2005-03-11 |
2008-08-21 |
アルコン,インコーポレイテッド |
緑内障を処置するためのフリッツルド関連蛋白質―1のrnai媒介性阻害
|
GB0505081D0
(en)
*
|
2005-03-14 |
2005-04-20 |
Genomica Sau |
Downregulation of interleukin-12 expression by means of rnai technology
|
US8999943B2
(en)
*
|
2005-03-14 |
2015-04-07 |
Board Of Regents, The University Of Texas System |
Antigene oligomers inhibit transcription
|
JP4585342B2
(ja)
*
|
2005-03-18 |
2010-11-24 |
株式会社資生堂 |
不全角化を抑制する物質のスクリーニング方法、同方法によりスクリーニングされた物質及び不全角化を抑制する方法
|
EP1877556B1
(en)
*
|
2005-03-25 |
2011-09-14 |
Medtronic, Inc. |
Use of anti-tnf or anti-il1 rnai to suppress pro- inflammatory cytokine actions locally to treat pain
|
JP2008537551A
(ja)
*
|
2005-03-31 |
2008-09-18 |
カランド ファーマシューティカルズ, インコーポレイテッド |
リボヌクレオチドレダクターゼサブユニット2の阻害剤およびその使用
|
WO2006113743A2
(en)
*
|
2005-04-18 |
2006-10-26 |
Massachusetts Institute Of Technology |
Compositions and methods for rna interference with sialidase expression and uses thereof
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
WO2006121960A2
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
US9505867B2
(en)
*
|
2005-05-31 |
2016-11-29 |
Ecole Polytechmique Fédérale De Lausanne |
Triblock copolymers for cytoplasmic delivery of gene-based drugs
|
US20070048293A1
(en)
*
|
2005-05-31 |
2007-03-01 |
The Trustees Of The University Of Pennsylvania |
Manipulation of PTEN in T cells as a strategy to modulate immune responses
|
JP2008545749A
(ja)
*
|
2005-06-01 |
2008-12-18 |
デューク ユニバーシティ |
血管内膜過形成を阻害する方法
|
JP5371424B2
(ja)
*
|
2005-06-01 |
2013-12-18 |
ポリプラス トランスフェクション エスアー |
Rna干渉のためのオリゴヌクレオチドおよびその生物学的適用
|
WO2006131925A2
(en)
*
|
2005-06-10 |
2006-12-14 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
|
CN100445381C
(zh)
*
|
2005-06-10 |
2008-12-24 |
中国人民解放军军事医学科学院基础医学研究所 |
带有单链polyA尾巴的siRNA分子制备方法和应用
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
US7838503B2
(en)
*
|
2005-06-15 |
2010-11-23 |
Children's Medical Center Corporation |
Methods for extending the replicative lifespan of cells
|
FI20050640A0
(fi)
*
|
2005-06-16 |
2005-06-16 |
Faron Pharmaceuticals Oy |
Yhdisteitä amiinioksidaasista riippuvien sairauksien tai häiriöiden hoitoon tai estoon
|
US7868159B2
(en)
*
|
2005-06-23 |
2011-01-11 |
Baylor College Of Medicine |
Modulation of negative immune regulators and applications for immunotherapy
|
EP1896084A4
(en)
*
|
2005-06-27 |
2010-10-20 |
Alnylam Pharmaceuticals Inc |
RNAI MODULATION OF HIF-1 AND THERAPEUTIC APPLICATIONS THEREOF
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
JP5383186B2
(ja)
|
2005-07-07 |
2014-01-08 |
イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム リミテッド |
H19をダウンレギュレートする核酸薬剤、及びそれを使用する方法
|
US8703769B2
(en)
|
2005-07-15 |
2014-04-22 |
The University Of North Carolina At Chapel Hill |
Use of EGFR inhibitors to prevent or treat obesity
|
CN101228268A
(zh)
*
|
2005-07-25 |
2008-07-23 |
德累斯顿工业大学 |
Rna扩增和/或rna标记用的rna依赖的rna聚合酶,方法及试剂盒
|
WO2007014370A2
(en)
*
|
2005-07-28 |
2007-02-01 |
University Of Delaware |
Small regulatory rnas and methods of use
|
US7919583B2
(en)
|
2005-08-08 |
2011-04-05 |
Discovery Genomics, Inc. |
Integration-site directed vector systems
|
US20070213257A1
(en)
*
|
2005-08-12 |
2007-09-13 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for complexes of nucleic acids and peptides
|
WO2007022470A2
(en)
|
2005-08-18 |
2007-02-22 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating neurological disease
|
US20070054873A1
(en)
*
|
2005-08-26 |
2007-03-08 |
Protiva Biotherapeutics, Inc. |
Glucocorticoid modulation of nucleic acid-mediated immune stimulation
|
EP1937312B1
(en)
*
|
2005-08-30 |
2016-06-29 |
Ionis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
US20090018097A1
(en)
*
|
2005-09-02 |
2009-01-15 |
Mdrna, Inc |
Modification of double-stranded ribonucleic acid molecules
|
US20090221673A1
(en)
*
|
2005-09-13 |
2009-09-03 |
Rigby William F C |
Compositions and Methods for Regulating RNA Translation via CD154 CA-Dinucleotide Repeat
|
CA2620387C
(en)
|
2005-09-20 |
2018-09-18 |
Basf Plant Science Gmbh |
Methods for controlling gene expression using ta-sirna
|
FR2890859B1
(fr)
|
2005-09-21 |
2012-12-21 |
Oreal |
Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase
|
WO2007041213A2
(en)
*
|
2005-09-30 |
2007-04-12 |
St. Jude Children's Research Hospital |
Methods for regulation of p53 translation and function
|
US8168584B2
(en)
|
2005-10-08 |
2012-05-01 |
Potentia Pharmaceuticals, Inc. |
Methods of treating age-related macular degeneration by compstatin and analogs thereof
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
US7838658B2
(en)
*
|
2005-10-20 |
2010-11-23 |
Ian Maclachlan |
siRNA silencing of filovirus gene expression
|
GB0521351D0
(en)
*
|
2005-10-20 |
2005-11-30 |
Genomica Sau |
Modulation of TRPV expression levels
|
GB0521716D0
(en)
*
|
2005-10-25 |
2005-11-30 |
Genomica Sau |
Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
|
JP4952944B2
(ja)
*
|
2005-10-27 |
2012-06-13 |
国立大学法人 奈良先端科学技術大学院大学 |
Singarの発現または機能の抑制による神経軸索の形成・伸長と神経再生への応用
|
US7320965B2
(en)
|
2005-10-28 |
2008-01-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Huntingtin gene
|
CA2628300C
(en)
|
2005-11-02 |
2018-04-17 |
Protiva Biotherapeutics, Inc. |
Modified sirna molecules and uses thereof
|
AU2006311725B2
(en)
*
|
2005-11-04 |
2011-11-24 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of NAV1.8 gene
|
EP1951318B1
(en)
*
|
2005-11-07 |
2012-10-17 |
British Columbia Cancer Agency |
Inhibition of autophagy genes in cancer chemotherapy
|
EP2363134B1
(en)
*
|
2005-11-09 |
2014-01-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor V Leiden mutant gene
|
EP2431467A3
(en)
|
2005-11-17 |
2012-05-02 |
Board Of Regents, The University Of Texas |
Modulation of gene expression by oligomers targeted to chromosomal DNA
|
US8603991B2
(en)
|
2005-11-18 |
2013-12-10 |
Gradalis, Inc. |
Individualized cancer therapy
|
US8916530B2
(en)
*
|
2005-11-18 |
2014-12-23 |
Gradalis, Inc. |
Individualized cancer therapy
|
US20080125384A1
(en)
*
|
2005-11-21 |
2008-05-29 |
Shuewi Yang |
Simultaneous silencing and restoration of gene function
|
US8153362B2
(en)
*
|
2005-11-24 |
2012-04-10 |
Jichi Medical University |
Mitochondrial function of prohibitin 2 (PHB2)
|
US9267937B2
(en)
|
2005-12-15 |
2016-02-23 |
Massachusetts Institute Of Technology |
System for screening particles
|
CA2634286A1
(en)
*
|
2005-12-22 |
2007-08-09 |
Samuel Jotham Reich |
Compositions and methods for regulating complement system
|
AR057252A1
(es)
*
|
2005-12-27 |
2007-11-21 |
Alcon Mfg Ltd |
Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares
|
US8673873B1
(en)
*
|
2005-12-28 |
2014-03-18 |
Alcon Research, Ltd. |
RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of cAMP-related ocular disorders
|
EP1976567B1
(en)
*
|
2005-12-28 |
2020-05-13 |
The Scripps Research Institute |
Natural antisense and non-coding rna transcripts as drug targets
|
US8058252B2
(en)
*
|
2005-12-30 |
2011-11-15 |
Institut Gustave Roussy |
Use of inhibitors of scinderin and/or ephrin-A1 for treating tumors
|
US20090060921A1
(en)
*
|
2006-01-17 |
2009-03-05 |
Biolex Therapeutics, Inc. |
Glycan-optimized anti-cd20 antibodies
|
CA2637254A1
(en)
|
2006-01-17 |
2007-07-26 |
Biolex Therapeutics, Inc. |
Compositions and methods for humanization and optimization of n-glycans in plants
|
WO2009051846A2
(en)
|
2007-10-18 |
2009-04-23 |
Cell Signaling Technology, Inc. |
Translocation and mutant ros kinase in human non-small cell lung carcinoma
|
US7825099B2
(en)
|
2006-01-20 |
2010-11-02 |
Quark Pharmaceuticals, Inc. |
Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
|
ES2539830T3
(es)
|
2006-01-20 |
2015-07-06 |
Cell Signaling Technology, Inc. |
ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano
|
NL2000439C2
(nl)
|
2006-01-20 |
2009-03-16 |
Quark Biotech |
Therapeutische toepassingen van inhibitoren van RTP801.
|
US20120208824A1
(en)
|
2006-01-20 |
2012-08-16 |
Cell Signaling Technology, Inc. |
ROS Kinase in Lung Cancer
|
WO2007087451A2
(en)
*
|
2006-01-25 |
2007-08-02 |
University Of Massachusetts |
Compositions and methods for enhancing discriminatory rna interference
|
WO2007085485A2
(en)
*
|
2006-01-27 |
2007-08-02 |
Santaris Pharma A/S |
Lna modified phosphorothiolated oligonucleotides
|
US8229398B2
(en)
*
|
2006-01-30 |
2012-07-24 |
Qualcomm Incorporated |
GSM authentication in a CDMA network
|
WO2007091269A2
(en)
*
|
2006-02-08 |
2007-08-16 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
US7910566B2
(en)
|
2006-03-09 |
2011-03-22 |
Quark Pharmaceuticals Inc. |
Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
|
FI20060246A0
(fi)
|
2006-03-16 |
2006-03-16 |
Jukka Westermarck |
Uusi kasvua stimuloiva proteiini ja sen käyttö
|
WO2007109609A2
(en)
*
|
2006-03-17 |
2007-09-27 |
The Board Of Trustees Of The University Of Illinois |
Method for inhibiting angiogenesis
|
AU2007229161B2
(en)
|
2006-03-23 |
2012-07-12 |
Roche Innovation Center Copenhagen A/S |
Small internally segmented interfering RNA
|
FR2898908A1
(fr)
|
2006-03-24 |
2007-09-28 |
Agronomique Inst Nat Rech |
Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence
|
BRPI0709147A2
(pt)
*
|
2006-03-24 |
2011-06-28 |
Novartis Ag |
composições de dsrna e métodos para tratamento de infecção por hpv
|
WO2007115047A2
(en)
*
|
2006-03-29 |
2007-10-11 |
Senesco Technologies, Inc. |
Inhibition of hiv replication and expression of p24 with eif-5a
|
JP2009534309A
(ja)
|
2006-03-31 |
2009-09-24 |
マサチューセッツ インスティテュート オブ テクノロジー |
治療剤の標的化送達のためのシステム
|
NZ571568A
(en)
|
2006-03-31 |
2010-11-26 |
Alnylam Pharmaceuticals Inc |
Double-stranded RNA molecule compositions and methods for inhibiting expression of Eg5 gene
|
EP2007891A2
(en)
*
|
2006-04-06 |
2008-12-31 |
DKFZ Deutsches Krebsforschungszentrum |
Method to inhibit the propagation of an undesired cell population
|
WO2008108776A1
(en)
*
|
2006-04-07 |
2008-09-12 |
Chimeros, Inc. |
Compositions and methods for treating b- cell malignancies
|
JP5524610B2
(ja)
|
2006-04-07 |
2014-06-18 |
ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク |
トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法
|
US9044461B2
(en)
|
2006-04-07 |
2015-06-02 |
The Research Foundation Of State University Of New York |
Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
|
EP2371957A1
(en)
*
|
2006-04-12 |
2011-10-05 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to hepcidin
|
US20100055116A1
(en)
*
|
2006-04-13 |
2010-03-04 |
Liou Hsiou-Chi |
Methods and Compositions for Targeting c-Rel
|
WO2007120847A2
(en)
|
2006-04-14 |
2007-10-25 |
Massachusetts Institute Of Technology |
Identifying and modulating molecular pathways that mediate nervous system plasticity
|
DK2447359T3
(en)
|
2006-04-14 |
2016-02-08 |
Cell Signaling Technology Inc |
Genetic defects and mutated ALK kinase in human solid tumors
|
WO2007127919A2
(en)
*
|
2006-04-28 |
2007-11-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the jc virus
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
CN101484588B
(zh)
|
2006-05-11 |
2013-11-06 |
阿尔尼拉姆医药品有限公司 |
抑制pcsk9基因表达的组合物和方法
|
JP5630998B2
(ja)
|
2006-05-15 |
2014-11-26 |
マサチューセッツ インスティテュート オブ テクノロジー |
機能的粒子のためのポリマー
|
US20090130212A1
(en)
*
|
2006-05-15 |
2009-05-21 |
Physical Pharmaceutica, Llc |
Composition and improved method for preparation of small particles
|
US20070269892A1
(en)
*
|
2006-05-18 |
2007-11-22 |
Nastech Pharmaceutical Company Inc. |
FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA
|
WO2007137239A2
(en)
*
|
2006-05-19 |
2007-11-29 |
The Scripps Research Institute |
Treatment of protein misfolding
|
EP2392583A1
(en)
*
|
2006-05-19 |
2011-12-07 |
Alnylam Europe AG. |
RNAi modulation of Aha and therapeutic uses thereof
|
CA2653451C
(en)
*
|
2006-05-22 |
2015-12-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
US9273356B2
(en)
|
2006-05-24 |
2016-03-01 |
Medtronic, Inc. |
Methods and kits for linking polymorphic sequences to expanded repeat mutations
|
US20070275923A1
(en)
*
|
2006-05-25 |
2007-11-29 |
Nastech Pharmaceutical Company Inc. |
CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY
|
US8598333B2
(en)
*
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
GB0610542D0
(en)
*
|
2006-05-26 |
2006-07-05 |
Medical Res Council |
Screening method
|
EP2026843A4
(en)
|
2006-06-09 |
2011-06-22 |
Quark Pharmaceuticals Inc |
THERAPEUTIC USES OF RTP801L INHIBITORS
|
US7915399B2
(en)
|
2006-06-09 |
2011-03-29 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
US20080152654A1
(en)
*
|
2006-06-12 |
2008-06-26 |
Exegenics, Inc., D/B/A Opko Health, Inc. |
COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS
|
WO2007147067A2
(en)
*
|
2006-06-14 |
2007-12-21 |
Rosetta Inpharmatics Llc |
Methods and compositions for regulating cell cycle progression
|
WO2007150030A2
(en)
|
2006-06-23 |
2007-12-27 |
Massachusetts Institute Of Technology |
Microfluidic synthesis of organic nanoparticles
|
WO2008008719A2
(en)
*
|
2006-07-10 |
2008-01-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the myc gene
|
GB0613753D0
(en)
*
|
2006-07-11 |
2006-08-23 |
Norwegian Radium Hospital Res |
Method
|
WO2008008986A2
(en)
|
2006-07-13 |
2008-01-17 |
University Of Iowa Research Foundation |
Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration
|
JP4756271B2
(ja)
*
|
2006-07-18 |
2011-08-24 |
独立行政法人産業技術総合研究所 |
ガン細胞の老化、アポトーシス誘導剤
|
CA2658550C
(en)
|
2006-07-21 |
2018-06-19 |
Silence Therapeutics Ag |
Means for inhibiting the expression of protein kinase 3
|
US20080039415A1
(en)
*
|
2006-08-11 |
2008-02-14 |
Gregory Robert Stewart |
Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
|
WO2008024844A2
(en)
*
|
2006-08-22 |
2008-02-28 |
The Johns Hopkins University |
Anticancer combination therapies
|
DE102006039479A1
(de)
|
2006-08-23 |
2008-03-06 |
Febit Biotech Gmbh |
Programmierbare Oligonukleotidsynthese
|
US7872118B2
(en)
*
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
CA2663962A1
(en)
*
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
|
CA2663878A1
(en)
*
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Mir-200 regulated genes and pathways as targets for therapeutic intervention
|
CA2663581C
(en)
|
2006-09-21 |
2016-03-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the hamp gene
|
AU2007299705B2
(en)
|
2006-09-22 |
2012-09-06 |
Dharmacon, Inc. |
Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
|
CA2666185A1
(en)
*
|
2006-10-11 |
2008-04-17 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Influenza targets
|
WO2008063760A2
(en)
*
|
2006-10-18 |
2008-05-29 |
The University Of Texas M.D. Anderson Cancer Center |
Methods for treating cancer targeting transglutaminase
|
JP2010507387A
(ja)
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のsiRNAおよびその使用方法
|
WO2008052774A2
(en)
|
2006-10-31 |
2008-05-08 |
Noxxon Pharma Ag |
Methods for detection of a single- or double-stranded nucleic acid molecule
|
US9279127B2
(en)
|
2006-11-01 |
2016-03-08 |
The Medical Research Fund At The Tel-Aviv Sourasky Medical Center |
Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression
|
US9375440B2
(en)
|
2006-11-03 |
2016-06-28 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
US8324367B2
(en)
|
2006-11-03 |
2012-12-04 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
US8252526B2
(en)
*
|
2006-11-09 |
2012-08-28 |
Gradalis, Inc. |
ShRNA molecules and methods of use thereof
|
US8758998B2
(en)
|
2006-11-09 |
2014-06-24 |
Gradalis, Inc. |
Construction of bifunctional short hairpin RNA
|
US8906874B2
(en)
|
2006-11-09 |
2014-12-09 |
Gradalis, Inc. |
Bi-functional shRNA targeting Stathmin 1 and uses thereof
|
US8034921B2
(en)
*
|
2006-11-21 |
2011-10-11 |
Alnylam Pharmaceuticals, Inc. |
IRNA agents targeting CCR5 expressing cells and uses thereof
|
US7819842B2
(en)
|
2006-11-21 |
2010-10-26 |
Medtronic, Inc. |
Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
|
US7988668B2
(en)
|
2006-11-21 |
2011-08-02 |
Medtronic, Inc. |
Microsyringe for pre-packaged delivery of pharmaceuticals
|
JP5271715B2
(ja)
*
|
2006-11-22 |
2013-08-21 |
国立大学法人 東京大学 |
ジスルフィド架橋高分子ミセルを用いた環境応答性siRNAキャリア
|
US20080199475A1
(en)
|
2006-11-27 |
2008-08-21 |
Patrys Limited |
Novel glycosylated peptide target in neoplastic cells
|
CA2670696A1
(en)
|
2006-11-27 |
2008-06-05 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
WO2008067373A2
(en)
*
|
2006-11-28 |
2008-06-05 |
Alcon Research, Ltd. |
RNAi-MEDIATED INHIBITION OF AQUAPORIN 1 FOR TREATMENT OF IOP-RELATED CONDITIONS
|
WO2008067526A2
(en)
*
|
2006-11-30 |
2008-06-05 |
University Of Southern California Usc Stevens |
Compositions and methods of sphingosine kinase inhibitors in radiation therapy of various cancers
|
AU2007333107A1
(en)
*
|
2006-12-08 |
2008-06-19 |
Asuragen, Inc. |
miR-21 regulated genes and pathways as targets for therapeutic intervention
|
CA2671299A1
(en)
*
|
2006-12-08 |
2008-06-19 |
Asuragen, Inc. |
Functions and targets of let-7 micro rnas
|
EA201101361A1
(ru)
*
|
2006-12-14 |
2012-11-30 |
Новартис Аг |
Композиции и способы, предназначенные для лечения мышечных и сердечно-сосудистых нарушений
|
US20090175827A1
(en)
*
|
2006-12-29 |
2009-07-09 |
Byrom Mike W |
miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
|
US7754698B2
(en)
*
|
2007-01-09 |
2010-07-13 |
Isis Pharmaceuticals, Inc. |
Modulation of FR-alpha expression
|
US9896511B2
(en)
|
2007-01-10 |
2018-02-20 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
CA2675967A1
(en)
*
|
2007-01-16 |
2008-07-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusale M |
Nucleic acid constructs and methods for specific silencing of h19
|
US20080171906A1
(en)
*
|
2007-01-16 |
2008-07-17 |
Everaerts Frank J L |
Tissue performance via hydrolysis and cross-linking
|
CA2712056C
(en)
|
2007-01-16 |
2016-06-21 |
The University Of Queensland |
Method of inducing an immune response
|
US20090074785A1
(en)
*
|
2007-01-16 |
2009-03-19 |
Smith Jeffrey W |
Compositions and methods for treatment of colorectal cancer
|
JP2010519179A
(ja)
*
|
2007-01-17 |
2010-06-03 |
アンスティトゥ・ドゥ・ルシェルシュ・クリニーク・ドゥ・モントリオール |
ヌクレオシドおよび四級炭素中心を有するヌクレオチド類似体ならびに使用方法
|
JP2010516786A
(ja)
|
2007-01-26 |
2010-05-20 |
ユニバーシティー オブ ルイヴィル リサーチ ファウンデーション,インコーポレーテッド |
ワクチンとしての使用のためのエキソソーム成分の改変
|
US20100196403A1
(en)
*
|
2007-01-29 |
2010-08-05 |
Jacob Hochman |
Antibody conjugates for circumventing multi-drug resistance
|
WO2008094860A2
(en)
*
|
2007-01-30 |
2008-08-07 |
Allergan, Inc. |
Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists
|
WO2008098248A2
(en)
|
2007-02-09 |
2008-08-14 |
Northwestern University |
Particles for detecting intracellular targets
|
WO2008098165A2
(en)
|
2007-02-09 |
2008-08-14 |
Massachusetts Institute Of Technology |
Oscillating cell culture bioreactor
|
DE102007008596B4
(de)
|
2007-02-15 |
2010-09-02 |
Friedrich-Schiller-Universität Jena |
Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
|
US8410334B2
(en)
*
|
2007-02-20 |
2013-04-02 |
Monsanto Technology Llc |
Invertebrate microRNAs
|
US7872119B2
(en)
|
2007-02-26 |
2011-01-18 |
Quark Pharmaceuticals, Inc. |
Inhibitors of RTP801 and their use in disease treatment
|
US20100292301A1
(en)
*
|
2007-02-28 |
2010-11-18 |
Elena Feinstein |
Novel sirna structures
|
JP2010519913A
(ja)
*
|
2007-03-02 |
2010-06-10 |
エムディーアールエヌエー,インコーポレイテッド |
Wnt遺伝子の発現を抑制するための核酸化合物およびその使用
|
US9018163B2
(en)
*
|
2007-03-02 |
2015-04-28 |
The Trustees Of The University Of Pennsylvania |
Modulating PDX-1 with PCIF1, methods and uses thereof
|
US20080299659A1
(en)
*
|
2007-03-02 |
2008-12-04 |
Nastech Pharmaceutical Company Inc. |
Nucleic acid compounds for inhibiting apob gene expression and uses thereof
|
US9085638B2
(en)
|
2007-03-07 |
2015-07-21 |
The Johns Hopkins University |
DNA vaccine enhancement with MHC class II activators
|
US20080260765A1
(en)
*
|
2007-03-15 |
2008-10-23 |
Johns Hopkins University |
HPV DNA Vaccines and Methods of Use Thereof
|
US7812002B2
(en)
|
2007-03-21 |
2010-10-12 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer
|
AU2008228814B2
(en)
|
2007-03-21 |
2014-03-06 |
Brookhaven Science Associates, Llc |
Combined hairpin-antisense compositions and methods for modulating expression
|
PE20090064A1
(es)
*
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
|
US7759320B2
(en)
*
|
2007-03-29 |
2010-07-20 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the Ebola
|
WO2008124634A1
(en)
|
2007-04-04 |
2008-10-16 |
Massachusetts Institute Of Technology |
Polymer-encapsulated reverse micelles
|
JP2010523595A
(ja)
|
2007-04-04 |
2010-07-15 |
マサチューセッツ インスティテュート オブ テクノロジー |
ポリ(アミノ酸)ターゲッティング部分
|
EP2134740A2
(en)
*
|
2007-04-09 |
2009-12-23 |
Chimeros, Inc. |
Self-assembling nanoparticle drug delivery system
|
JP5258874B2
(ja)
|
2007-04-10 |
2013-08-07 |
キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Rna干渉タグ
|
AU2008242842B2
(en)
*
|
2007-04-17 |
2014-06-05 |
Baxter Healthcare Sa |
Nucleic acid microparticles for pulmonary delivery
|
US8877917B2
(en)
*
|
2007-04-23 |
2014-11-04 |
Alnylam Pharmaceuticals, Inc. |
Glycoconjugates of RNA interference agents
|
WO2008143774A2
(en)
*
|
2007-05-01 |
2008-11-27 |
University Of Massachusetts |
Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy
|
US20100291042A1
(en)
|
2007-05-03 |
2010-11-18 |
The Brigham And Women's Hospital, Inc. |
Multipotent stem cells and uses thereof
|
JP5296328B2
(ja)
*
|
2007-05-09 |
2013-09-25 |
独立行政法人理化学研究所 |
1本鎖環状rnaおよびその製造方法
|
JP2010527375A
(ja)
*
|
2007-05-15 |
2010-08-12 |
ヘリコン セラピューティクス,インコーポレイテッド |
Gpr12の阻害による認知障害の治療方法
|
EP2152275A4
(en)
*
|
2007-05-15 |
2011-08-03 |
Helicon Therapeutics Inc |
METHODS OF IDENTIFYING GENES INVOLVED IN MEMORY FORMATION USING SMALL INTERFERING RNA (SIARN)
|
US20090131354A1
(en)
*
|
2007-05-22 |
2009-05-21 |
Bader Andreas G |
miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
|
PL2162538T3
(pl)
|
2007-05-22 |
2016-10-31 |
|
Oligomery do zastosowań terapeutycznych
|
CA3055145A1
(en)
|
2007-05-30 |
2008-12-11 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
CN101820757A
(zh)
|
2007-06-01 |
2010-09-01 |
普林斯顿大学托管委员会 |
通过调节宿主细胞代谢途径治疗病毒感染
|
WO2008153029A1
(ja)
|
2007-06-11 |
2008-12-18 |
Takara Bio Inc. |
特異的遺伝子発現方法
|
WO2008152636A2
(en)
*
|
2007-06-15 |
2008-12-18 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for inhibiting nadph oxidase expression
|
AR066984A1
(es)
|
2007-06-15 |
2009-09-23 |
Novartis Ag |
Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
|
SI2170403T1
(sl)
|
2007-06-27 |
2014-07-31 |
Quark Pharmaceuticals, Inc. |
Sestavki in postopki za inhibicijo ekspresije pro-apoptotskih genov
|
JP5547964B2
(ja)
|
2007-06-29 |
2014-07-16 |
株式会社ステリック再生医科学研究所 |
生理活性物質を定着および発現させる方法
|
CA2692503C
(en)
*
|
2007-07-05 |
2013-09-24 |
Novartis Ag |
Dsrna for treating viral infection
|
US9018180B2
(en)
*
|
2007-07-10 |
2015-04-28 |
Neurim Pharmaceuticals (1991) Ltd. |
CD44 splice variants in neurodegenerative diseases
|
US8828960B2
(en)
*
|
2007-07-17 |
2014-09-09 |
Idexx Laboratories, Inc. |
Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
|
JP2009033986A
(ja)
*
|
2007-07-31 |
2009-02-19 |
Sumitomo Chemical Co Ltd |
RNA干渉による遺伝子発現抑制のためのターゲット遺伝子としてのcar遺伝子の使用
|
EP2030615A3
(en)
|
2007-08-13 |
2009-12-02 |
ELFORD, Howard L. |
Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases
|
US8501929B2
(en)
*
|
2007-08-17 |
2013-08-06 |
Biochrom Pharma Inc. |
PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
|
CA2735166C
(en)
|
2007-08-27 |
2020-12-01 |
Boston Biomedical, Inc. |
Compositions of asymmetric interfering rna and uses thereof
|
KR20100047343A
(ko)
*
|
2007-08-30 |
2010-05-07 |
바이렉스 메디칼 코포레이션 |
항원 조성물 및 핵산의 표적화된 전달에서의 이의 용도
|
WO2009032364A1
(en)
*
|
2007-08-31 |
2009-03-12 |
Ghc Research Development Corporation |
Activation of nuclear factor-kappa b
|
US8183221B2
(en)
|
2007-09-05 |
2012-05-22 |
Medtronic, Inc. |
Suppression of SCN9A gene expression and/or function for the treatment of pain
|
AU2008298592A1
(en)
*
|
2007-09-14 |
2009-03-19 |
Nitto Denko Corporation |
Drug carriers
|
EP2198050A1
(en)
|
2007-09-14 |
2010-06-23 |
Asuragen, INC. |
Micrornas differentially expressed in cervical cancer and uses thereof
|
JP5049713B2
(ja)
*
|
2007-09-14 |
2012-10-17 |
株式会社コナミデジタルエンタテインメント |
ゲームシステム並びにこれを構成するゲーム装置及び課題報知装置
|
DK2195428T3
(en)
|
2007-09-19 |
2014-03-03 |
Applied Biosystems Llc |
SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF
|
US20100204303A1
(en)
*
|
2007-09-25 |
2010-08-12 |
Idexx Laboratories, Inc. |
Pharmaceutical Compositions for Administering Oligonucleotides
|
US20100136026A1
(en)
*
|
2007-09-26 |
2010-06-03 |
Kerr William G |
Ship Inhibition to Direct Hematopoietic Stem Cells and Induce Extramedullary Hematopoiesis
|
ES2376175T3
(es)
|
2007-09-28 |
2012-03-09 |
Bind Biosciences, Inc. |
Direccionamiento a células de c�?ncer usando nanopart�?culas.
|
US20120082659A1
(en)
*
|
2007-10-02 |
2012-04-05 |
Hartmut Land |
Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
|
CN101815521B
(zh)
*
|
2007-10-03 |
2014-12-10 |
夸克制药公司 |
新siRNA结构
|
EP2205746A4
(en)
*
|
2007-10-04 |
2010-12-22 |
Univ Texas |
MODULATION OF GENE EXPRESSION WITH AGRNA AND GAPS WITH ANTISENSE TRANSCRIPTS AS A TARGET
|
US10736848B2
(en)
|
2007-10-12 |
2020-08-11 |
Massachusetts Institute Of Technology |
Vaccine nanotechnology
|
US8097712B2
(en)
|
2007-11-07 |
2012-01-17 |
Beelogics Inc. |
Compositions for conferring tolerance to viral disease in social insects, and the use thereof
|
US20100098664A1
(en)
*
|
2007-11-28 |
2010-04-22 |
Mathieu Jean-Francois Desclaux |
Lentiviral vectors allowing RNAi mediated inhibition of GFAP and vimentin expression
|
JP2011505144A
(ja)
*
|
2007-11-30 |
2011-02-24 |
ベイラー カレッジ オブ メディシン |
樹状細胞ワクチン組成物およびその使用
|
US8071562B2
(en)
*
|
2007-12-01 |
2011-12-06 |
Mirna Therapeutics, Inc. |
MiR-124 regulated genes and pathways as targets for therapeutic intervention
|
US8501912B2
(en)
|
2007-12-03 |
2013-08-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Filipil compositions and methods for treating cancer
|
WO2009082606A2
(en)
*
|
2007-12-04 |
2009-07-02 |
Alnylam Pharmaceuticals, Inc. |
Folate conjugates
|
US20090247608A1
(en)
|
2007-12-04 |
2009-10-01 |
Alnylam Pharmaceuticals, Inc. |
Targeting Lipids
|
JP5530933B2
(ja)
|
2007-12-10 |
2014-06-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
第vii因子遺伝子発現阻害のための組成物及び方法
|
WO2009074990A2
(en)
*
|
2007-12-12 |
2009-06-18 |
Quark Pharmaceuticals, Inc. |
Rtp801l sirna compounds and methods of use thereof
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
JP2011506484A
(ja)
*
|
2007-12-13 |
2011-03-03 |
アルニラム ファーマシューティカルズ, インコーポレイテッド |
Rsv感染の予防または治療のための方法および組成物
|
US20090176729A1
(en)
*
|
2007-12-14 |
2009-07-09 |
Alnylam Pharmaceuticals, Inc. |
Method of treating neurodegenerative disease
|
US7845686B2
(en)
*
|
2007-12-17 |
2010-12-07 |
S & B Technical Products, Inc. |
Restrained pipe joining system for plastic pipe
|
KR100949791B1
(ko)
*
|
2007-12-18 |
2010-03-30 |
이동기 |
오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도
|
US20090192114A1
(en)
*
|
2007-12-21 |
2009-07-30 |
Dmitriy Ovcharenko |
miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
|
WO2009090639A2
(en)
*
|
2008-01-15 |
2009-07-23 |
Quark Pharmaceuticals, Inc. |
Sirna compounds and methods of use thereof
|
MX2010008394A
(es)
*
|
2008-01-31 |
2010-11-12 |
Alnylam Pharmaceuticals Inc |
Metodos optimizados para administracion de arndc focalizando el gen pcsk9.
|
US20090263803A1
(en)
*
|
2008-02-08 |
2009-10-22 |
Sylvie Beaudenon |
Mirnas differentially expressed in lymph nodes from cancer patients
|
EP3643782A1
(en)
|
2008-02-11 |
2020-04-29 |
Phio Pharmaceuticals Corp. |
Modified rnai polynucleotides and uses thereof
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
US7977321B2
(en)
*
|
2008-02-12 |
2011-07-12 |
University Of Tennessee Research Foundation |
Small interfering RNAs targeting feline herpes virus
|
US8288525B2
(en)
*
|
2008-02-12 |
2012-10-16 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of CD45 gene
|
JP2011515072A
(ja)
*
|
2008-02-13 |
2011-05-19 |
エラン ファーマ インターナショナル リミテッド |
α−シヌクレインキナーゼ
|
DE102009043743B4
(de)
|
2009-03-13 |
2016-10-13 |
Friedrich-Schiller-Universität Jena |
Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
|
WO2009103067A2
(en)
*
|
2008-02-14 |
2009-08-20 |
The Children's Hospital Of Philadelphia |
Compositions and methods to treat asthma
|
AU2009221775B2
(en)
|
2008-03-05 |
2015-05-07 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Eg5 and VEGF genes
|
EP2268832A2
(en)
*
|
2008-03-06 |
2011-01-05 |
Asuragen, INC. |
Microrna markers for recurrence of colorectal cancer
|
CN102036689B
(zh)
*
|
2008-03-17 |
2014-08-06 |
得克萨斯系统大学董事会 |
神经肌肉突触维持和再生中涉及的微小rna的鉴定
|
KR20100132531A
(ko)
*
|
2008-03-20 |
2010-12-17 |
쿠아크 파마수티칼스 인코퍼레이티드 |
RTP801을 억제하기 위한 신규 siRNA 화합물
|
EP2271757A2
(en)
*
|
2008-03-26 |
2011-01-12 |
Asuragen, INC. |
Compositions and methods related to mir-16 and therapy of prostate cancer
|
EP2105145A1
(en)
*
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Method for muscle-specific delivery lipid-conjugated oligonucleotides
|
RU2501859C2
(ru)
*
|
2008-03-31 |
2013-12-20 |
Нэшнл Инститьют Оф Эдванст Индастриал Сайенс Энд Текнолоджи |
Модифицированная липидами двухцепочечная рнк, обладающая мощным эффектом рнк-интерференции
|
TWI348916B
(en)
*
|
2008-04-03 |
2011-09-21 |
Univ Nat Taiwan |
A novel treatment tool for cancer: rna interference of bcas2
|
US20090258928A1
(en)
*
|
2008-04-08 |
2009-10-15 |
Asuragen, Inc. |
Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
|
EP2271368B1
(en)
|
2008-04-11 |
2018-12-05 |
Cedars-Sinai Medical Center |
Poly(beta malic acid) with pendant leu-leu-leu tripeptide for effective cytoplasmic drug delivery
|
JP5788312B2
(ja)
|
2008-04-11 |
2015-09-30 |
アルニラム ファーマスーティカルズ インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
標的リガンドをエンドソーム分解性成分と組み合わせることによる核酸の部位特異的送達
|
PL2279254T3
(pl)
|
2008-04-15 |
2017-11-30 |
Protiva Biotherapeutics Inc. |
Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
|
WO2009144704A2
(en)
*
|
2008-04-15 |
2009-12-03 |
Quark Pharmaceuticals, Inc. |
siRNA COMPOUNDS FOR INHIBITING NRF2
|
US20090285861A1
(en)
*
|
2008-04-17 |
2009-11-19 |
Tzyy-Choou Wu |
Tumor cell-based cancer immunotherapeutic compositions and methods
|
WO2009129465A2
(en)
*
|
2008-04-17 |
2009-10-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of xbp-1 gene
|
USRE48948E1
(en)
|
2008-04-18 |
2022-03-01 |
Warsaw Orthopedic, Inc. |
Clonidine compounds in a biodegradable polymer
|
WO2009129616A1
(en)
|
2008-04-21 |
2009-10-29 |
Tissue Regeneration Therapeutics, Inc. |
Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents
|
US8324366B2
(en)
|
2008-04-29 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for delivering RNAI using lipoproteins
|
WO2009134443A2
(en)
*
|
2008-05-02 |
2009-11-05 |
The Brigham And Women's Hospital, Inc. |
Rna-induced translational silencing and cellular apoptosis
|
US8258111B2
(en)
|
2008-05-08 |
2012-09-04 |
The Johns Hopkins University |
Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
|
US20090291073A1
(en)
*
|
2008-05-20 |
2009-11-26 |
Ward Keith W |
Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same
|
US20100009451A1
(en)
*
|
2008-05-30 |
2010-01-14 |
Sigma Aldrich Company |
Compositions and methods for specifically silencing a target nucleic acid
|
WO2009149182A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
EP2293800B1
(en)
|
2008-06-06 |
2016-10-05 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treatment of ear disorders
|
US20090305611A1
(en)
*
|
2008-06-06 |
2009-12-10 |
Flow International Corporation |
Device and method for improving accuracy of a high-pressure fluid jet apparatus
|
JP2011522552A
(ja)
*
|
2008-06-13 |
2011-08-04 |
リボックス・ゲーエムベーハー |
化学的に修飾されたrnaの酵素的合成のための方法
|
WO2010005741A1
(en)
*
|
2008-06-16 |
2010-01-14 |
Georgia Tech Research Corporation |
Nanogels for cellular delivery of therapeutics
|
TWI455944B
(zh)
|
2008-07-01 |
2014-10-11 |
Daiichi Sankyo Co Ltd |
雙股多核苷酸
|
US20110184046A1
(en)
*
|
2008-07-11 |
2011-07-28 |
Dinah Wen-Yee Sah |
Compositions And Methods For Inhibiting Expression Of GSK-3 Genes
|
WO2010008562A2
(en)
|
2008-07-16 |
2010-01-21 |
Recombinetics |
Methods and materials for producing transgenic animals
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
US8039658B2
(en)
*
|
2008-07-25 |
2011-10-18 |
Air Products And Chemicals, Inc. |
Removal of trace arsenic impurities from triethylphosphate (TEPO)
|
WO2010014857A2
(en)
*
|
2008-07-30 |
2010-02-04 |
University Of Massachusetts |
Chromosome therapy
|
EP2323695B1
(en)
|
2008-08-19 |
2018-12-05 |
Nektar Therapeutics |
Complexes of small-interfering nucleic acids
|
KR101877698B1
(ko)
*
|
2008-08-25 |
2018-07-12 |
엑스칼리아드 파마슈티컬즈, 인코포레이티드 |
결합 조직 성장 인자에 대한 안티센스 올리고뉴클레오타이드 및 그의 용도
|
WO2011028218A1
(en)
|
2009-09-02 |
2011-03-10 |
Alnylam Pharmaceuticals, Inc. |
Process for triphosphate oligonucleotide synthesis
|
WO2010030963A2
(en)
|
2008-09-15 |
2010-03-18 |
Children's Medical Center Corporation |
Modulation of bcl11a for treatment of hemoglobinopathies
|
US8664189B2
(en)
|
2008-09-22 |
2014-03-04 |
Rxi Pharmaceuticals Corporation |
RNA interference in skin indications
|
JP2012513953A
(ja)
|
2008-09-23 |
2012-06-21 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
|
CA2739170A1
(en)
|
2008-09-25 |
2010-04-01 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
|
EP2344638A1
(en)
*
|
2008-10-06 |
2011-07-20 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of an rna from west nile virus
|
US8802646B2
(en)
*
|
2008-10-08 |
2014-08-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease
|
WO2010042292A1
(en)
*
|
2008-10-08 |
2010-04-15 |
Trustees Of Dartmouth College |
Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease
|
US9149492B2
(en)
|
2008-10-08 |
2015-10-06 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
|
US9388413B2
(en)
|
2008-10-08 |
2016-07-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
US9388414B2
(en)
|
2008-10-08 |
2016-07-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
EP2350043B9
(en)
|
2008-10-09 |
2014-08-20 |
TEKMIRA Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
US8343498B2
(en)
|
2008-10-12 |
2013-01-01 |
Massachusetts Institute Of Technology |
Adjuvant incorporation in immunonanotherapeutics
|
US8343497B2
(en)
|
2008-10-12 |
2013-01-01 |
The Brigham And Women's Hospital, Inc. |
Targeting of antigen presenting cells with immunonanotherapeutics
|
US8591905B2
(en)
|
2008-10-12 |
2013-11-26 |
The Brigham And Women's Hospital, Inc. |
Nicotine immunonanotherapeutics
|
US8277812B2
(en)
|
2008-10-12 |
2012-10-02 |
Massachusetts Institute Of Technology |
Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
|
US9458472B2
(en)
*
|
2008-10-15 |
2016-10-04 |
Massachusetts Institute Of Technology |
Detection and destruction of cancer cells using programmed genetic vectors
|
CN102245772A
(zh)
|
2008-10-15 |
2011-11-16 |
索马根尼科斯公司 |
抑制基因表达的短发卡rna
|
ES2656516T3
(es)
|
2008-10-20 |
2018-02-27 |
Alnylam Pharmaceuticals, Inc. |
Composiciones y métodos para inhibir la expresión de transtiretina
|
EP2350277A1
(en)
*
|
2008-10-23 |
2011-08-03 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules
|
WO2010046889A1
(en)
*
|
2008-10-23 |
2010-04-29 |
Quark Pharmaceuticals, Inc. |
Methods for delivery of sirna to bone marrow cells and uses thereof
|
KR102264822B1
(ko)
|
2008-11-10 |
2021-06-14 |
알닐람 파마슈티칼스 인코포레이티드 |
치료제 운반용 신규 지질 및 조성물
|
US20100179213A1
(en)
*
|
2008-11-11 |
2010-07-15 |
Mirna Therapeutics, Inc. |
Methods and Compositions Involving miRNAs In Cancer Stem Cells
|
JP2012508770A
(ja)
*
|
2008-11-13 |
2012-04-12 |
モッドジーン リミテッド ライアビリティ カンパニー |
非脳組織におけるアミロイドβ負荷の変更
|
US9074211B2
(en)
|
2008-11-19 |
2015-07-07 |
Rxi Pharmaceuticals Corporation |
Inhibition of MAP4K4 through RNAI
|
AU2009316853A1
(en)
|
2008-11-21 |
2010-05-27 |
Isis Pharmaceuticals, Inc. |
Combination therapy for the treatment of cancer
|
CN106955360A
(zh)
|
2008-11-24 |
2017-07-18 |
西北大学 |
多价rna纳米颗粒组合物
|
EP2191834A1
(en)
*
|
2008-11-26 |
2010-06-02 |
Centre National De La Recherche Scientifique (Cnrs) |
Compositions and methods for treating retrovirus infections
|
AU2009322290B2
(en)
|
2008-12-03 |
2016-06-16 |
Arcturus Therapeutics, Inc. |
Una oligomer structures for therapeutic agents
|
US8470792B2
(en)
|
2008-12-04 |
2013-06-25 |
Opko Pharmaceuticals, Llc. |
Compositions and methods for selective inhibition of VEGF
|
US20100291188A1
(en)
*
|
2008-12-04 |
2010-11-18 |
Musc Foundation For Research Development |
Periostin Inhibitory Compositions for Myocardial Regeneration, Methods of Delivery, and Methods of Using Same
|
HUE034832T2
(hu)
|
2008-12-09 |
2021-12-28 |
Hoffmann La Roche |
Anti-PD-L1 antitestek és alkalmazásuk T-sejt-funkció fokozására
|
AU2009324534B2
(en)
*
|
2008-12-10 |
2015-07-30 |
Alnylam Pharmaceuticals, Inc. |
GNAQ targeted dsRNA compositions and methods for inhibiting expression
|
CN103397031A
(zh)
*
|
2008-12-11 |
2013-11-20 |
香雪集团(香港)有限公司 |
有效抑制病毒感染的siRNA组合物及方法
|
JPWO2010067882A1
(ja)
*
|
2008-12-12 |
2012-05-24 |
株式会社クレハ |
癌及び喘息治療のための医薬組成物
|
WO2010077894A2
(en)
|
2008-12-16 |
2010-07-08 |
Bristol-Myers Squibb Company |
Methods of inhibiting quiescent tumor proliferation
|
US20110288155A1
(en)
|
2008-12-18 |
2011-11-24 |
Elena Feinstein |
Sirna compounds and methods of use thereof
|
CN102300556B
(zh)
|
2008-12-26 |
2015-04-29 |
株式会社三养生物制药 |
含有阴离子药物的药物组合物及其制备方法
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
US8980820B2
(en)
*
|
2009-01-19 |
2015-03-17 |
The Research Foundation For The State University Of New York |
Fatty acid binding proteins as drug targets for endocannabinoids
|
WO2010084134A1
(en)
*
|
2009-01-20 |
2010-07-29 |
Vib Vzw |
Phd2 inhibition for blood vessel normalization, and uses thereof
|
CA2750561C
(en)
|
2009-01-26 |
2017-10-10 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein c-iii expression
|
KR20110100316A
(ko)
*
|
2009-02-03 |
2011-09-09 |
에프. 호프만-라 로슈 아게 |
Ptp1b 유전자의 발현을 억제하기 위한 조성물 및 방법
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
ES2637174T3
(es)
|
2009-02-12 |
2017-10-11 |
Cell Signaling Technology, Inc. |
Expresión de ROS mutante en el cáncer de hígado humano
|
JP2012518401A
(ja)
*
|
2009-02-24 |
2012-08-16 |
リボックス・ゲーエムベーハー |
低分子干渉rnaの改善された設計
|
EP2403863B1
(en)
|
2009-03-02 |
2013-08-28 |
Alnylam Pharmaceuticals Inc. |
Nucleic acid chemical modifications
|
WO2010107955A2
(en)
*
|
2009-03-19 |
2010-09-23 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF BTB AND CNC HOMOLOGY 1, BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR 1 (BACH 1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) SEQUENCE LISTING
|
US8444983B2
(en)
|
2009-03-23 |
2013-05-21 |
Quark Pharmaceuticals, Inc. |
Composition of anti-ENDO180 antibodies and methods of use for the treatment of cancer and fibrotic diseases
|
US20100239632A1
(en)
|
2009-03-23 |
2010-09-23 |
Warsaw Orthopedic, Inc. |
Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
|
WO2010120874A2
(en)
|
2009-04-14 |
2010-10-21 |
Chimeros, Inc. |
Chimeric therapeutics, compositions, and methods for using same
|
WO2010124231A2
(en)
*
|
2009-04-24 |
2010-10-28 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
US8367350B2
(en)
|
2009-04-29 |
2013-02-05 |
Morehouse School Of Medicine |
Compositions and methods for diagnosis, prognosis and management of malaria
|
BRPI1007708A2
(pt)
|
2009-05-05 |
2020-08-18 |
Beeologics Inc |
agente do ácido nucleico isolado, construção de ácido nucleico, ácido nucleico isolado, composição ingerível pelas abelhas, método para reduzir a susceptibilidade de uma abelha a infecção por nosema e método para reduzir a susceptibilidade das abelhas melíferas à infecçção por nosema
|
US8933049B2
(en)
*
|
2009-05-05 |
2015-01-13 |
Medical Diagnostic Laboratories, Llc |
Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
|
US9255266B2
(en)
|
2009-05-06 |
2016-02-09 |
Rutgers, The State University Of New Jersey |
RNA targeting in alpha-synucleinopathies
|
WO2010130771A2
(en)
*
|
2009-05-15 |
2010-11-18 |
F. Hoffmann-La Roche Ag |
Compositions and methods for inhibiting expression of glucocorticoid receptor (gcr) genes
|
US20120114710A1
(en)
*
|
2009-05-18 |
2012-05-10 |
Lynn Kirkpatrick |
Carbon nanotubes complexed with multiple bioactive agents and methods related thereto
|
EP2432499A2
(en)
|
2009-05-20 |
2012-03-28 |
Schering Corporation |
Modulation of pilr receptors to treat microbial infections
|
US20100304995A1
(en)
*
|
2009-05-22 |
2010-12-02 |
Li Shen |
Arrays and Methods for Reverse Genetic Functional Analysis
|
WO2010141511A2
(en)
|
2009-06-01 |
2010-12-09 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotides for multivalent rna interference, compositions and methods of use thereof
|
WO2010140024A1
(en)
*
|
2009-06-03 |
2010-12-09 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods for diagnosing and treating a renal disease in an individual
|
CA2764503A1
(en)
|
2009-06-05 |
2010-12-09 |
University Of Florida Research Foundation, Inc. |
Isolation and targeted suppression of lignin biosynthetic genes from sugarcane
|
CA2763537A1
(en)
|
2009-06-08 |
2010-12-16 |
Quark Pharmaceuticals, Inc. |
Methods for treating chronic kidney disease
|
EA028860B1
(ru)
|
2009-06-10 |
2018-01-31 |
Арбутус Биофарма Корпорэйшн |
Улучшенная липидная композиция
|
AU2010259295B2
(en)
|
2009-06-10 |
2015-05-07 |
Temasek Life Sciences Laboratory Limited |
Virus induced gene silencing (VIGS) for functional analysis of genes in cotton.
|
WO2010148013A2
(en)
*
|
2009-06-15 |
2010-12-23 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated dsrna targeting the pcsk9 gene
|
WO2010147992A1
(en)
|
2009-06-15 |
2010-12-23 |
Alnylam Pharmaceuticals, Inc. |
Methods for increasing efficacy of lipid formulated sirna
|
US20100324124A1
(en)
*
|
2009-06-17 |
2010-12-23 |
Massachusetts Institute Of Technology |
Compositions and methods relating to DNA-based particles
|
US20100323018A1
(en)
*
|
2009-06-17 |
2010-12-23 |
Massachusetts Institute Of Technology |
Branched DNA/RNA monomers and uses thereof
|
GB0910723D0
(en)
*
|
2009-06-22 |
2009-08-05 |
Sylentis Sau |
Novel drugs for inhibition of gene expression
|
JP5766188B2
(ja)
|
2009-07-01 |
2015-08-19 |
プロチバ バイオセラピューティクス インコーポレイティッド |
固形腫瘍に治療剤を送達するための脂質製剤
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
US8871730B2
(en)
|
2009-07-13 |
2014-10-28 |
Somagenics Inc. |
Chemical modification of short small hairpin RNAs for inhibition of gene expression
|
US8716464B2
(en)
|
2009-07-20 |
2014-05-06 |
Thomas W. Geisbert |
Compositions and methods for silencing Ebola virus gene expression
|
KR101733255B1
(ko)
|
2009-07-20 |
2017-05-08 |
브리스톨-마이어스 스큅 컴퍼니 |
증식성 질환의 상승작용적 치료를 위한 항ctla4 항체와 다양한 치료 요법의 조합
|
EP2464661B1
(en)
|
2009-08-13 |
2018-01-17 |
The Johns Hopkins University |
Methods of modulating immune function with anti-b7-h7cr antibodies
|
AP3574A
(en)
|
2009-08-14 |
2016-02-08 |
Alnylam Pharmaceuticals Inc |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
EP3811950A1
(en)
|
2009-08-24 |
2021-04-28 |
Phigenix, Inc. |
Targeting pax2 for the treatment of breast cancer
|
ES2655079T3
(es)
|
2009-09-10 |
2018-02-16 |
Merck Sharp & Dohme Corp. |
Uso de antagonistas de IL-33 para tratar enfermedades fibróticas
|
WO2011032100A1
(en)
|
2009-09-11 |
2011-03-17 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Inhibitors of kshv vil6 and human il6
|
EP2295543A1
(en)
|
2009-09-11 |
2011-03-16 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Method for the preparation of an influenza virus
|
US8859516B2
(en)
|
2009-09-15 |
2014-10-14 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
|
US8916693B2
(en)
|
2009-09-17 |
2014-12-23 |
Nektar Therapeutics |
Monoconjugated chitosans as delivery agents for small interfering nucleic acids
|
WO2011038031A1
(en)
|
2009-09-22 |
2011-03-31 |
Alnylam Pharmaceuticals, Inc. |
Dual targeting sirna agents
|
CA2775092A1
(en)
*
|
2009-09-23 |
2011-03-31 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing genes expressed in cancer
|
US20150025122A1
(en)
|
2009-10-12 |
2015-01-22 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
US8962584B2
(en)
|
2009-10-14 |
2015-02-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Compositions for controlling Varroa mites in bees
|
JP5866119B2
(ja)
|
2009-10-30 |
2016-02-17 |
ノースウェスタン ユニバーシティ |
鋳型ナノ複合体
|
US9101643B2
(en)
|
2009-11-03 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of transthyretin (TTR)
|
US9799416B2
(en)
*
|
2009-11-06 |
2017-10-24 |
Terrapower, Llc |
Methods and systems for migrating fuel assemblies in a nuclear fission reactor
|
US8901097B2
(en)
|
2009-11-08 |
2014-12-02 |
Quark Pharmaceuticals, Inc. |
Methods for delivery of siRNA to the spinal cord and therapies arising therefrom
|
WO2011062997A2
(en)
|
2009-11-17 |
2011-05-26 |
Musc Foundation For Research Development |
Human monoclonal antibodies to human nucleolin
|
EP2504435B1
(en)
|
2009-11-26 |
2019-11-13 |
Quark Pharmaceuticals, Inc. |
Sirna compounds comprising terminal substitutions
|
EP3296398A1
(en)
|
2009-12-07 |
2018-03-21 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
EP2510098B1
(en)
|
2009-12-09 |
2015-02-11 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the cns
|
KR101692063B1
(ko)
*
|
2009-12-09 |
2017-01-03 |
닛토덴코 가부시키가이샤 |
hsp47 발현의 조절
|
WO2011072240A1
(en)
|
2009-12-10 |
2011-06-16 |
Cedars-Sinai Medical Center |
Drug delivery of temozolomide for systemic based treatment of cancer
|
EP2336171A1
(en)
|
2009-12-11 |
2011-06-22 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Novel targets for the treatment of proliferative diseases
|
US8691227B2
(en)
|
2009-12-17 |
2014-04-08 |
Merck Sharp & Dohme Corp. |
Methods of treating multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease using agonists antibodies to PILR-α
|
AR079494A1
(es)
*
|
2009-12-18 |
2012-02-01 |
Novartis Ag |
Composiciones organicas para tratar las enfermedades relacionadas con el factor de choque por calor 1 hsf1
|
AU2010330814B2
(en)
|
2009-12-18 |
2017-01-12 |
Acuitas Therapeutics Inc. |
Methods and compositions for delivery of nucleic acids
|
WO2011079077A1
(en)
|
2009-12-23 |
2011-06-30 |
Gradalis, Inc. |
Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
|
SG181823A1
(en)
|
2009-12-23 |
2012-07-30 |
Max Planck Gesellschaft |
Influenza targets
|
US20130023578A1
(en)
|
2009-12-31 |
2013-01-24 |
Samyang Biopharmaceuticals Corporation |
siRNA for inhibition of c-Met expression and anticancer composition containing the same
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
TW201124159A
(en)
*
|
2010-01-07 |
2011-07-16 |
Univ Nat Cheng Kung |
Small interference RNA molecule and applications thereof
|
RU2611191C2
(ru)
*
|
2010-01-11 |
2017-02-21 |
Курна, Инк. |
Лечение заболеваний, связанных со связывающим половые гормоны глобулином (гспг), путем ингибирования природного антисмыслового транскрипта к гспг
|
WO2011088058A1
(en)
*
|
2010-01-12 |
2011-07-21 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expressions of factor vii and pten genes
|
DE102010004957A1
(de)
|
2010-01-14 |
2011-07-21 |
Universitätsklinikum Jena, 07743 |
Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
US9198972B2
(en)
|
2010-01-28 |
2015-12-01 |
Alnylam Pharmaceuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
WO2011094546A2
(en)
|
2010-01-29 |
2011-08-04 |
St. Jude Children's Research Hospital |
Oligonucleotides which inhibit p53 induction in response to cellular stress
|
WO2011098449A1
(en)
|
2010-02-10 |
2011-08-18 |
Novartis Ag |
Methods and compounds for muscle growth
|
AU2011227050B2
(en)
|
2010-03-19 |
2016-12-08 |
University Of South Alabama |
Methods and compositions for the treatment of cancer
|
CN105131067B
(zh)
|
2010-03-24 |
2019-02-19 |
雷克西制药公司 |
皮肤与纤维化症候中的rna干扰
|
WO2011119852A1
(en)
|
2010-03-24 |
2011-09-29 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering rnai compounds
|
WO2011119871A1
(en)
|
2010-03-24 |
2011-09-29 |
Rxi Phrmaceuticals Corporation |
Rna interference in ocular indications
|
US8455455B1
(en)
|
2010-03-31 |
2013-06-04 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing genes involved in hemorrhagic fever
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
US20130260460A1
(en)
|
2010-04-22 |
2013-10-03 |
Isis Pharmaceuticals Inc |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
WO2011133658A1
(en)
|
2010-04-22 |
2011-10-27 |
Boston Medical Center Corporation |
Compositions and methods for targeting and delivering therapeutics into cells
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
NZ603339A
(en)
|
2010-04-29 |
2015-01-30 |
Isis Pharmaceuticals Inc |
Modulation of transthyretin expression
|
WO2011137363A1
(en)
|
2010-04-30 |
2011-11-03 |
Allergan, Inc. |
Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
|
ES2596431T3
(es)
|
2010-05-04 |
2017-01-09 |
The Brigham And Women's Hospital, Inc. |
Antagonista de cadherina-11 para el tratamiento de fibrosis
|
US8563243B2
(en)
*
|
2010-05-12 |
2013-10-22 |
University Of South Carolina |
Methods for affecting homology-directed DNA double stranded break repair
|
US20110293700A1
(en)
|
2010-05-26 |
2011-12-01 |
Selecta Biosciences, Inc. |
Nanocarrier compositions with uncoupled adjuvant
|
EP2390327A1
(en)
|
2010-05-27 |
2011-11-30 |
Sylentis S.A. |
siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
DE102010022937A1
(de)
|
2010-06-04 |
2011-12-08 |
Universitätsklinikum Jena |
Zellspezifisch aktivierbare biologisch wirksame Moleküle auf Grundlage von siRNA, Verfahren zu deren Aktivierung sowie Applikationskit zur Verabreichung
|
US20130236968A1
(en)
|
2010-06-21 |
2013-09-12 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
CN103097534B
(zh)
|
2010-06-24 |
2017-07-28 |
夸克制药公司 |
针对rhoa的双链rna化合物及其用途
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US20130202652A1
(en)
|
2010-07-30 |
2013-08-08 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US20120101108A1
(en)
|
2010-08-06 |
2012-04-26 |
Cell Signaling Technology, Inc. |
Anaplastic Lymphoma Kinase In Kidney Cancer
|
WO2012027206A1
(en)
|
2010-08-24 |
2012-03-01 |
Merck Sharp & Dohme Corp. |
SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER
|
US8933051B2
(en)
|
2010-09-30 |
2015-01-13 |
University Of Zurich |
Treatment of B-cell lymphoma with microRNA
|
US20140315973A1
(en)
*
|
2010-10-07 |
2014-10-23 |
Agency For Science, Technology And Research |
Parp-1 inhibitors
|
WO2012051491A1
(en)
|
2010-10-14 |
2012-04-19 |
The United States Of America, As Represented By The Secretary National Institutes Of Health |
Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
|
CN103328633B
(zh)
*
|
2010-10-22 |
2018-07-10 |
成均馆大学校产学协力团 |
诱导rna干扰的核酸分子及其用途
|
EP3327125B1
(en)
|
2010-10-29 |
2020-08-05 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
|
WO2012071436A1
(en)
|
2010-11-24 |
2012-05-31 |
Genentech, Inc. |
Method of treating autoimmune inflammatory disorders using il-23r loss-of-function mutants
|
AU2011338682B2
(en)
|
2010-12-06 |
2017-04-27 |
Quark Pharmaceuticals, Inc. |
Double stranded oligonucleotide compounds comprising threose modifications
|
WO2012102793A2
(en)
|
2010-12-10 |
2012-08-02 |
Zirus, Inc. |
Mammalian genes involved in toxicity and infection
|
US8575328B2
(en)
*
|
2010-12-14 |
2013-11-05 |
The United States Of America, As Represented By The Secretary Of Agriculture |
Formicidae (ant) control using double-stranded RNA constructs
|
US9623041B2
(en)
|
2010-12-30 |
2017-04-18 |
Cedars-Sinai Medical Center |
Polymalic acid-based nanobiopolymer compositions
|
GB2502462B
(en)
|
2011-01-10 |
2018-08-08 |
Univ Michigan Regents |
Stem cell factor inhibitor
|
AU2012207606B2
(en)
|
2011-01-11 |
2017-02-23 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
DE102011009470A1
(de)
|
2011-01-21 |
2012-08-09 |
Friedrich-Schiller-Universität Jena |
Biologisch wirksame Nukleotid-Moleküle zur gezielten Abtötung von Zellen, Verwendung derselben sowie Applikationskit
|
MX365647B
(es)
|
2011-02-02 |
2019-06-10 |
Excaliard Pharmaceuticals Inc |
El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas.
|
JP2014506789A
(ja)
|
2011-02-03 |
2014-03-20 |
マーナ セラピューティクス インコーポレイテッド |
miR−124の合成模倣体
|
US9796979B2
(en)
|
2011-03-03 |
2017-10-24 |
Quark Pharmaceuticals Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
CA2828544A1
(en)
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
US9233121B2
(en)
*
|
2011-03-11 |
2016-01-12 |
Board Of Regents Of The University Of Nebraska |
Compositions and methods for the treatment of cancer
|
WO2012125872A2
(en)
|
2011-03-15 |
2012-09-20 |
University Of Utah Research Foundation |
Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
|
US9458456B2
(en)
*
|
2011-04-01 |
2016-10-04 |
University Of South Alabama |
Methods and compositions for the diagnosis, classification, and treatment of cancer
|
CA2832073A1
(en)
|
2011-04-12 |
2012-10-18 |
Terrence R. Burke |
Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
|
CA2832972C
(en)
|
2011-04-13 |
2019-04-30 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of ptp1b expression
|
EP2696678B1
(en)
|
2011-04-15 |
2019-11-20 |
Molecular Transfer, Inc. |
Agents for improved delivery of nucleic acids to eukaryotic cells
|
US8716257B2
(en)
*
|
2011-04-15 |
2014-05-06 |
Sutter West Bay Hospitals |
CMV gene products promote cancer stem cell growth
|
EP2709664A4
(en)
|
2011-05-20 |
2015-06-10 |
Us Government |
BLOCKADE OF TL1A-DR3 INTERACTIONS FOR THE TREATMENT OF T-CELL-MEDIATED DISEASES AND ANTIBODIES THEREOF
|
EP3011974B1
(en)
|
2011-06-02 |
2018-08-08 |
University Of Louisville Research Foundation, Inc. |
Anti-nucleolin agent-conjugated nanoparticles
|
CA3191066A1
(en)
|
2011-06-21 |
2012-12-27 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inhibition of expression of apolipoprotein c-iii (apoc3) genes
|
EP4092120A1
(en)
|
2011-06-21 |
2022-11-23 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (anglptl3) irna compositions and methods of use thereof
|
WO2012177949A2
(en)
|
2011-06-21 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of protein c (proc) genes
|
EP2723861A4
(en)
|
2011-06-21 |
2014-12-10 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR INHIBITING HEPCIDINE ANTIMICROBIAL PEPTIDE (HAMP) OR THE ASSOCIATED GENE EXPRESSION
|
WO2013001372A2
(en)
|
2011-06-30 |
2013-01-03 |
University Of Oslo |
Methods and compositions for inhibition of activation of regulatory t cells
|
WO2013003697A1
(en)
|
2011-06-30 |
2013-01-03 |
Trustees Of Boston University |
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
|
KR20160084505A
(ko)
|
2011-07-06 |
2016-07-13 |
쉬케후세트 솔란데트 에이치에프 |
Egfr 표적화 요법
|
WO2013006861A1
(en)
|
2011-07-07 |
2013-01-10 |
University Of Georgia Research Foundation, Inc. |
Sorghum grain shattering gene and uses thereof in altering seed dispersal
|
US8853181B2
(en)
|
2011-07-21 |
2014-10-07 |
Albert Einstein College Of Medicine Of Yeshiva University |
Fidgetin-like 2 as a target to enhance wound healing
|
US9120858B2
(en)
|
2011-07-22 |
2015-09-01 |
The Research Foundation Of State University Of New York |
Antibodies to the B12-transcobalamin receptor
|
DE102011118024A1
(de)
|
2011-08-01 |
2013-02-07 |
Technische Universität Dresden |
Inhibitor der Expression der Pro-Caspase 1
|
EP3301178B1
(en)
|
2011-09-06 |
2021-10-13 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
The mirna-212/132 family as a therapeutic target
|
EP2747774A4
(en)
|
2011-09-09 |
2015-02-11 |
Biomed Realty L P |
METHOD AND COMPOSITIONS FOR CONTROLLING VIRUS PROTECTION
|
US9644241B2
(en)
|
2011-09-13 |
2017-05-09 |
Interpace Diagnostics, Llc |
Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
|
EP3456317A1
(en)
|
2011-09-27 |
2019-03-20 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
WO2013049389A1
(en)
|
2011-09-27 |
2013-04-04 |
Yale University |
Compositions and methods for transient expression of recombinant rna
|
EP3960726A1
(en)
|
2011-10-18 |
2022-03-02 |
Dicerna Pharmaceuticals, Inc. |
Amine cationic lipids and uses thereof
|
WO2013070821A1
(en)
|
2011-11-08 |
2013-05-16 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the nervous system
|
EP2592146A3
(en)
|
2011-11-14 |
2013-07-24 |
Silenseed Ltd |
Methods and compositions for treating prostate cancer
|
IN2014CN03463A
(no)
|
2011-11-18 |
2015-10-09 |
Alnylam Pharmaceuticals Inc |
|
WO2013082529A1
(en)
|
2011-12-02 |
2013-06-06 |
Yale University |
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
|
US20150216998A1
(en)
|
2012-01-01 |
2015-08-06 |
Ramot At Tel-Aviv University Ltd. |
Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
|
WO2013103401A1
(en)
*
|
2012-01-06 |
2013-07-11 |
University Of South Alabama |
Methods and compositions for the treatment of cancer
|
BR112014016870A2
(pt)
|
2012-01-09 |
2017-06-27 |
Huesken Dieter |
composições orgânicas para tratar doenças relacionadas com beta-catenina
|
EP2802657B1
(en)
|
2012-01-12 |
2018-05-02 |
Quark Pharmaceuticals, Inc. |
Combination therapy for treating hearing and balance disorders
|
WO2013112458A1
(en)
|
2012-01-24 |
2013-08-01 |
Beth Israel Deaconess Medical Center, Inc. |
Novel chrebp isoforms and methods using the same
|
US9408832B2
(en)
|
2012-03-14 |
2016-08-09 |
University Of Central Florida Research Foundation, Inc. |
LIM kinasemodulating agents for neurofibromatoses therapy and methods for screening for same
|
WO2013138374A2
(en)
|
2012-03-15 |
2013-09-19 |
Curna, Inc. |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
DK2838998T3
(en)
|
2012-04-18 |
2018-01-15 |
Cell Signaling Technology Inc |
EGFR AND ROS1 IN CANCER
|
WO2013166043A1
(en)
|
2012-05-02 |
2013-11-07 |
Children's Hospital Medical Center |
Rejuvenation of precursor cells
|
EP3453762B1
(en)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
ES2716818T3
(es)
|
2012-05-22 |
2019-06-17 |
Olix Pharmaceuticals Inc |
Molécula de ácido nucleico inductora de interferencias de arn capaz de penetrar en las células y uso de la misma
|
DK2867368T3
(da)
|
2012-07-06 |
2022-01-31 |
Roussy Inst Gustave |
Samtidig detektering af kannibalisme og senescens som prognostisk markør for cancer
|
WO2014018375A1
(en)
|
2012-07-23 |
2014-01-30 |
Xenon Pharmaceuticals Inc. |
Cyp8b1 and uses thereof in therapeutic and diagnostic methods
|
JP6431480B2
(ja)
*
|
2012-08-31 |
2018-11-28 |
ザ ジェネラル ホスピタル コーポレイション |
アルツハイマー病の治療および診断のためのビオチン複合体
|
KR102120060B1
(ko)
|
2012-09-05 |
2020-06-09 |
실렌티스 에스.에이.유. |
눈 컨디션의 치료 및/또는 예방을 위한 조성물 및 방법에 있어서 siRNA 및 이의 용도
|
GB201215857D0
(en)
|
2012-09-05 |
2012-10-24 |
Sylentis Sau |
siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
WO2014043289A2
(en)
|
2012-09-12 |
2014-03-20 |
Quark Pharmaceuticals, Inc. |
Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof
|
EP2895608B1
(en)
|
2012-09-12 |
2018-12-05 |
Quark Pharmaceuticals, Inc. |
Double-stranded oligonucleotide molecules to p53 and methods of use thereof
|
JP6374388B2
(ja)
|
2012-09-21 |
2018-08-15 |
インテンシティ セラピューティクス, インク.Intensity Therapeutics, Inc. |
癌の治療方法
|
EP2904119B1
(en)
*
|
2012-10-02 |
2020-06-17 |
The General Hospital Corporation d/b/a Massachusetts General Hospital |
Methods relating to dna-sensing pathway related conditions
|
WO2014055825A1
(en)
|
2012-10-04 |
2014-04-10 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
A formulation of mycobacterial components as an adjuvant for inducing th17 responses
|
WO2014068072A1
(en)
|
2012-10-31 |
2014-05-08 |
Institut Gustave-Roussy |
Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
|
CA2930339A1
(en)
|
2012-11-13 |
2014-05-22 |
Jan Lotvall |
Delivery of therapeutic agent
|
DE102012022596B4
(de)
|
2012-11-15 |
2017-05-04 |
Friedrich-Schiller-Universität Jena |
Neue zellspezifisch wirksame Nukleotid-Moleküle und Applikationskit zu deren Anwendung
|
RS62243B9
(sr)
|
2012-11-15 |
2022-11-30 |
Apellis Pharmaceuticals Inc |
Analozi kompstatina sa produženim trajanjem dejstva i njihove kompozicije i postupci
|
BR112015011995B1
(pt)
|
2012-11-27 |
2023-02-07 |
Children's Medical Center Corporation |
Método para a produção de uma célula progenitora hematopoiética tendo bcl11a diminuído ou para aumentar seus níveis de hemoglobina fetal, composição e uso das mesmas
|
US9970002B2
(en)
|
2012-12-12 |
2018-05-15 |
Massachusetts Institute Of Technology |
Compositions and methods for functional nucleic acid delivery
|
WO2014095088A1
(en)
|
2012-12-21 |
2014-06-26 |
Sykehuset Sørlandet Hf |
Egfr targeted therapy of neurological disorders and pain
|
US9206423B2
(en)
*
|
2012-12-30 |
2015-12-08 |
The Regents Of The University Of California |
Methods of modulating compliance of the trabecular meshwork
|
US10258682B2
(en)
|
2013-01-16 |
2019-04-16 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Attenuated chlamydia vaccine
|
DE102013003869B4
(de)
|
2013-02-27 |
2016-11-24 |
Friedrich-Schiller-Universität Jena |
Verfahren zur gezielten Abtötung von Zellen durch zur mRNA-Anbindung ausgerichtete Nukleotid-Moleküle sowie Nukleotid-Moleküle und Applikationskit für solche Verwendung
|
CN105142614A
(zh)
|
2013-03-14 |
2015-12-09 |
迪克纳制药公司 |
用于配制阴离子试剂的方法
|
US10308687B2
(en)
|
2013-03-15 |
2019-06-04 |
Apellis Pharmaceuticals, Inc. |
Cell-penetrating compstatin analogs and uses thereof
|
WO2014150751A2
(en)
*
|
2013-03-15 |
2014-09-25 |
Novartis Ag |
Biomarkers associated with brm inhibition
|
WO2014144721A2
(en)
*
|
2013-03-15 |
2014-09-18 |
Genentech, Inc. |
Treating th2-mediated diseases by inhibition of bromodomains
|
WO2014160871A2
(en)
|
2013-03-27 |
2014-10-02 |
The General Hospital Corporation |
Methods and agents for treating alzheimer's disease
|
US20160146806A1
(en)
|
2013-05-17 |
2016-05-26 |
Amplimmune, Inc. |
Receptors for b7-h4
|
EP3013424A4
(en)
|
2013-06-25 |
2017-03-29 |
University of Canberra |
Methods and compositions for modulating cancer stem cells
|
TW201534578A
(zh)
|
2013-07-08 |
2015-09-16 |
Daiichi Sankyo Co Ltd |
新穎脂質
|
WO2015006554A1
(en)
|
2013-07-10 |
2015-01-15 |
The Regents Of The University Of Michigan |
Therapeutic antibodies and uses thereof
|
UA122662C2
(uk)
|
2013-07-19 |
2020-12-28 |
Монсанто Текнолоджі Ллс |
Композиція та спосіб боротьби з leptinotarsa
|
US10711106B2
(en)
|
2013-07-25 |
2020-07-14 |
The University Of Chicago |
High aspect ratio nanofibril materials
|
US20160208247A1
(en)
|
2013-07-31 |
2016-07-21 |
Qbi Enterprises Ltd. |
Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
|
EP3027222A1
(en)
|
2013-07-31 |
2016-06-08 |
QBI Enterprises Ltd. |
Sphingolipid-polyalkylamine-oligonucleotide compounds
|
US9670492B2
(en)
|
2013-08-28 |
2017-06-06 |
Ionis Pharmaceuticals, Inc. |
Modulation of prekallikrein (PKK) expression
|
CN110559435B
(zh)
|
2013-09-11 |
2023-10-20 |
伊戈尔生物药品股份有限公司 |
包含离子性液体的液体蛋白质制剂
|
SG11201601408PA
(en)
|
2013-09-18 |
2016-04-28 |
Univ Canberra |
Stem cell modulation ii
|
JP6546161B2
(ja)
|
2013-10-04 |
2019-07-17 |
ノバルティス アーゲー |
B型肝炎ウイルスを治療するための有機化合物
|
JP6694811B2
(ja)
|
2013-10-04 |
2020-05-20 |
ノバルティス アーゲー |
RNA干渉に使用するためのRNAi剤用の3’末端キャップ
|
EP2865757A1
(en)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA and their use in methods and compositions for inhibiting the expression of the PDK1 gene.
|
EP2865758A1
(en)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA and their use in methods and compositions for inhibiting the expression of the ORAI1 gene
|
EP2865756A1
(en)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA and their use in methods and compositions for inhibiting the expression of the FLAP gene.
|
JP6672156B2
(ja)
|
2013-11-11 |
2020-03-25 |
サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. |
親油性部分にコンジュゲートされたミオスタチン低分子干渉核酸(siNA)の全身性送達
|
WO2015077566A1
(en)
|
2013-11-21 |
2015-05-28 |
Huang Zhen |
Methods for structural determination of selenium derivatized nucleic acid complexes
|
JP6772062B2
(ja)
|
2013-12-02 |
2020-10-21 |
フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. |
癌の免疫療法
|
US10150965B2
(en)
|
2013-12-06 |
2018-12-11 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA
|
CN104830906B
(zh)
|
2014-02-12 |
2018-09-04 |
北京维通达生物技术有限公司 |
一种重编程获得功能性人肝脏实质细胞的方法
|
WO2015132303A1
(en)
|
2014-03-04 |
2015-09-11 |
Sylentis Sau |
Sirnas and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
CN106103475B
(zh)
|
2014-03-11 |
2021-01-12 |
塞勒克提斯公司 |
产生同种异体移植相容的t细胞的方法
|
ES2727078T3
(es)
*
|
2014-03-20 |
2019-10-14 |
Oommen Varghese |
Moléculas de ácido ribonucleico pequeño de interferencia mejoradas
|
EP3122365B1
(en)
|
2014-03-25 |
2023-05-03 |
Arcturus Therapeutics, Inc. |
Transthyretin allele selective una oligomers for gene silencing
|
WO2015148580A2
(en)
|
2014-03-25 |
2015-10-01 |
Arcturus Therapeutics, Inc. |
Una oligomers having reduced off-target effects in gene silencing
|
US9856475B2
(en)
|
2014-03-25 |
2018-01-02 |
Arcturus Therapeutics, Inc. |
Formulations for treating amyloidosis
|
HRP20220798T1
(hr)
|
2014-04-01 |
2022-10-14 |
Biogen Ma Inc. |
Pripravci za modulaciju ekspresije sod-1
|
WO2015153339A2
(en)
|
2014-04-01 |
2015-10-08 |
Monsanto Technology Llc |
Compositions and methods for controlling insect pests
|
SG10201809290SA
(en)
|
2014-04-25 |
2019-01-30 |
Childrens Medical Ct Corp |
Compositions and Methods to Treating Hemoglobinopathies
|
EP3137119B1
(en)
|
2014-04-28 |
2020-07-01 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using a nucleic acid targeting mdm2
|
AU2015252917B2
(en)
|
2014-05-01 |
2019-09-26 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating PKK expression
|
ES2883837T3
(es)
|
2014-05-02 |
2021-12-09 |
The Res Institute At Nationwide Childrens Hospital |
Composiciones y métodos para inmunomodulación de anti-LYST
|
CA2948844C
(en)
|
2014-05-12 |
2020-06-30 |
The Johns Hopkins University |
Engineering synthetic brain penetrating gene vectors
|
US10335500B2
(en)
|
2014-05-12 |
2019-07-02 |
The Johns Hopkins University |
Highly stable biodegradable gene vector platforms for overcoming biological barriers
|
US10100308B2
(en)
|
2014-05-29 |
2018-10-16 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
TR201908550T4
(tr)
|
2014-06-04 |
2019-07-22 |
Exicure Inc |
Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
|
CN104120127B
(zh)
*
|
2014-07-01 |
2016-09-21 |
清华大学 |
分离的寡核苷酸及其应用
|
CN106604993A
(zh)
|
2014-07-29 |
2017-04-26 |
孟山都技术公司 |
用于控制昆虫害虫的组合物和方法
|
WO2016019126A1
(en)
|
2014-07-30 |
2016-02-04 |
The Research Foundation For The State University Of New York |
System and method for delivering genetic material or protein to cells
|
EP3180033B1
(de)
|
2014-08-14 |
2023-06-07 |
Friedrich-Schiller-Universität Jena |
Peptid zur verwendung in der reduktion von nebenwirkungen in form von immunstimulatorischen reaktionen/effekten
|
CA2958704A1
(en)
|
2014-08-25 |
2016-03-03 |
University Of Canberra |
Compositions for modulating cancer stem cells and uses therefor
|
JP6672270B2
(ja)
|
2014-08-29 |
2020-03-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
トランスサイレチン(ttr)媒介アミロイドーシスの治療方法
|
CN107073294A
(zh)
|
2014-09-05 |
2017-08-18 |
阿克赛医药公司 |
使用靶向tyr或mmp1的核酸治疗老化和皮肤病症的方法
|
US11390885B2
(en)
|
2014-09-15 |
2022-07-19 |
Children's Medical Center Corporation |
Methods and compositions to increase somatic cell nuclear transfer (SCNT) efficiency by removing histone H3-lysine trimethylation
|
CA2962406A1
(en)
|
2014-09-25 |
2016-03-31 |
Cold Spring Harbor Laboratory |
Treatment of rett syndrome
|
AU2015325055B2
(en)
|
2014-10-01 |
2021-02-25 |
Eagle Biologics, Inc. |
Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
|
EP4029508A1
(en)
|
2014-10-10 |
2022-07-20 |
Idera Pharmaceuticals, Inc. |
Treatment of cancer using tlr9 agonists and checkpoint inhibitors
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
WO2016057693A1
(en)
|
2014-10-10 |
2016-04-14 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
US10538762B2
(en)
*
|
2014-10-14 |
2020-01-21 |
The Board Of Regents Of The University Of Texas System |
Allele selective inhibition of mutant C9orf72 foci expression by duplex RNAS targeting the expanded hexanucleotide repeat
|
WO2016061642A1
(en)
|
2014-10-22 |
2016-04-28 |
Katholieke Universiteit Leuven Ku Leuven Research & Development |
Modulating adipose tissue and adipogenesis
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
WO2016077624A1
(en)
|
2014-11-12 |
2016-05-19 |
Nmc, Inc. |
Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same
|
WO2016081444A1
(en)
|
2014-11-17 |
2016-05-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
WO2016081621A1
(en)
|
2014-11-18 |
2016-05-26 |
Yale University |
Formulations for targeted release of agents under low ph conditions and methods of use thereof
|
AU2015349680A1
(en)
|
2014-11-21 |
2017-06-08 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
WO2016094374A1
(en)
*
|
2014-12-09 |
2016-06-16 |
The Board Of Regents Of The University Of Texas System |
Compositions and mentods for treatment of friedreich's ataxia
|
US20180002702A1
(en)
|
2014-12-26 |
2018-01-04 |
Nitto Denko Corporation |
Methods and compositions for treating malignant tumors associated with kras mutation
|
US10792299B2
(en)
|
2014-12-26 |
2020-10-06 |
Nitto Denko Corporation |
Methods and compositions for treating malignant tumors associated with kras mutation
|
US10264976B2
(en)
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
BR112017015705A2
(pt)
|
2015-01-22 |
2018-03-20 |
Monsanto Technology Llc |
composições e métodos para controle de leptinotarsa
|
WO2016161299A1
(en)
|
2015-04-01 |
2016-10-06 |
Arcturus Therapeutics, Inc. |
Therapeutic una oligomers and uses thereof
|
IL295159A
(en)
|
2015-04-13 |
2022-09-01 |
Alnylam Pharmaceuticals Inc |
Preparations of angiopoietin-like 3 irna and methods of using them
|
WO2016168197A1
(en)
|
2015-04-15 |
2016-10-20 |
Yale University |
Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof
|
EP3291839A1
(en)
|
2015-05-05 |
2018-03-14 |
The University of Louisville Research Foundation, Inc. |
Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents
|
ES2835861T3
(es)
|
2015-05-08 |
2021-06-23 |
Childrens Medical Ct Corp |
Direccionamiento de regiones funcionales del potenciador de BCL11A para la reinducción de hemoglobina fetal
|
WO2016191811A1
(en)
|
2015-06-03 |
2016-12-08 |
The University Of Queensland |
Mobilizing agents and uses therefor
|
EP3307890A1
(en)
|
2015-06-10 |
2018-04-18 |
Board of Regents, The University of Texas System |
Use of exosomes for the treatment of disease
|
EP3318275A4
(en)
*
|
2015-06-30 |
2019-02-06 |
Tadamitsu Kishimoto |
NOVEL THERAPEUTIC AGENT AGAINST PULMONARY DISEASES AND / OR SCREENING METHOD THEREOF
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
CN108135923B
(zh)
|
2015-07-06 |
2021-03-02 |
菲奥医药公司 |
靶向超氧化物歧化酶1(sod1)的核酸分子
|
KR102640776B1
(ko)
|
2015-07-10 |
2024-02-23 |
아이오니스 파마수티컬즈, 인코포레이티드 |
디아실글리세롤 아실전이효소 2(dgat2) 조절제
|
WO2017015671A1
(en)
|
2015-07-23 |
2017-01-26 |
Arcturus Therapeutics, Inc. |
Compositions for treating amyloidosis
|
MA43335B1
(fr)
|
2015-07-31 |
2021-01-29 |
Alnylam Pharmaceuticals Inc |
Compositions d'arni de transthyrétine (ttr) et procédés pour les utiliser pour le traitement ou la prévention de maladies associées à ttr
|
MX2018002090A
(es)
|
2015-08-24 |
2018-09-12 |
Halo Bio Rnai Therapeutics Inc |
Nanoparticulas de polinucleótido para modulación de expresión génica y sus usos.
|
MA44908A
(fr)
|
2015-09-08 |
2018-07-18 |
Sylentis Sau |
Molécules d'arnsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène nrarp
|
GB201516685D0
(en)
*
|
2015-09-21 |
2015-11-04 |
Varghese Oommen P And Oommen Oommen P |
Nucleic acid molecules with enhanced activity
|
US10383935B2
(en)
|
2015-09-23 |
2019-08-20 |
Regents Of The University Of Minnesota |
Methods of making and using live attenuated viruses
|
US10086063B2
(en)
|
2015-09-23 |
2018-10-02 |
Regents Of The University Of Minnesota |
Methods of making and using live attenuated viruses
|
US10548959B2
(en)
|
2015-09-23 |
2020-02-04 |
Massachusetts Institute Of Technology |
Compositions and methods for modified dendrimer nanoparticle delivery
|
US10358497B2
(en)
|
2015-09-29 |
2019-07-23 |
Amgen Inc. |
Methods of treating cardiovascular disease with an ASGR inhibitor
|
JOP20210043A1
(ar)
*
|
2015-10-01 |
2017-06-16 |
Arrowhead Pharmaceuticals Inc |
تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
|
KR20180090785A
(ko)
|
2015-10-07 |
2018-08-13 |
아펠리스 파마슈티컬스 인코포레이티드 |
투여 요법
|
CN109563509B
(zh)
|
2015-10-19 |
2022-08-09 |
菲奥医药公司 |
靶向长非编码rna的减小尺寸的自递送核酸化合物
|
CN108699556B
(zh)
|
2015-11-16 |
2023-02-17 |
奥利克斯医药有限公司 |
使用靶向myd88或tlr3的rna复合物治疗老年性黄斑变性
|
WO2017095751A1
(en)
|
2015-12-02 |
2017-06-08 |
Partikula Llc |
Compositions and methods for modulating cancer cell metabolism
|
WO2017100193A1
(en)
|
2015-12-10 |
2017-06-15 |
Fibrogen, Inc. |
Methods for treatment of motor neuron diseases
|
CN108366964B
(zh)
|
2015-12-18 |
2022-04-08 |
三养控股公司 |
制备含阴离子药物的聚合物胶束的方法
|
BR102017001164A2
(pt)
|
2016-01-26 |
2019-03-06 |
Embrapa - Empresa Brasileira De Pesquisa Agropecuária |
Composições de rna de fita dupla para controle de diaphorina citri e métodos de uso.
|
CA3011894A1
(en)
|
2016-01-31 |
2017-08-03 |
University Of Massachusetts |
Branched oligonucleotides
|
WO2017134525A1
(en)
|
2016-02-02 |
2017-08-10 |
Olix Pharmaceuticals, Inc. |
TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGET lL4Rα, TRPA1, OR F2RL1
|
JP7003044B2
(ja)
|
2016-02-02 |
2022-01-20 |
オリックス ファーマシューティカルズ,インコーポレーテッド |
Angpt2およびpdgfbを標的化するrna複合体を用いる血管新生関連疾患の処置
|
MX2018010198A
(es)
|
2016-02-25 |
2019-06-12 |
Applied Biological Laboratories Inc |
Composiciones y metodos para proteger contra patogenos e irritantes transportados por el aire.
|
US20170360815A1
(en)
|
2016-02-25 |
2017-12-21 |
Applied Biological Laboratories, Inc. |
Compositions and methods for protecting against airborne pathogens and irritants
|
WO2017147594A1
(en)
|
2016-02-26 |
2017-08-31 |
Yale University |
COMPOSITIONS AND METHODS OF USING piRNAS IN CANCER DIAGNOSTICS AND THERAPEUTICS
|
US20210189062A1
(en)
|
2016-03-01 |
2021-06-24 |
Alexion Pharmaceuticals, Inc. |
Biodegradable activated polymers for therapeutic delivery
|
US11072777B2
(en)
|
2016-03-04 |
2021-07-27 |
University Of Louisville Research Foundation, Inc. |
Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (VSELs)
|
TWI783434B
(zh)
|
2016-03-07 |
2022-11-11 |
美商愛羅海德製藥公司 |
治療性化合物之標靶性配體
|
CN109310885B
(zh)
|
2016-03-15 |
2022-05-31 |
梅尔莎纳医疗公司 |
NaPi2b靶向抗体-药物缀合物及其使用方法
|
US20190117799A1
(en)
|
2016-04-01 |
2019-04-25 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
MA45470A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques kras et leurs utilisations
|
MA45349A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques egfr et leurs utilisations
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
MA45469A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques de bêta-caténine et leurs utilisations
|
EP3440090B1
(en)
|
2016-04-06 |
2022-09-28 |
Ohio State Innovation Foundation |
Rna ligand-displaying exosomes for specific delivery of therapeutics to cell by rna nanotechnology
|
EP3443093A4
(en)
|
2016-04-11 |
2020-01-01 |
Olix Pharmaceuticals, Inc. |
TREATMENT OF IDIOPATHIC LUNG FIBROSIS WITH RNA COMPLEXES TARGETED AGAINST THE TISSUE GROWTH FACTOR
|
BR112018071186A8
(pt)
*
|
2016-04-14 |
2023-03-28 |
Benitec Biopharma Ltd |
Rna, pluralidade de rnas, construto de interferência por rna dirigida por dna, composição, método para inibir a expressão de uma proteína, método para tratar distrofia muscular oculofaríngea e kit
|
EP3448997B1
(en)
|
2016-04-27 |
2020-10-14 |
Massachusetts Institute of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
WO2017197128A1
(en)
|
2016-05-11 |
2017-11-16 |
Yale University |
Poly(amine-co-ester) nanoparticles and methods of use thereof
|
KR101916652B1
(ko)
|
2016-06-29 |
2018-11-08 |
올릭스 주식회사 |
작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
|
BR112019000015A2
(pt)
|
2016-06-30 |
2019-04-24 |
Oncorus, Inc. |
distribuição por vírus oncolítico pseudotipado de polipeptídeos terapêuticos
|
RU2627179C1
(ru)
*
|
2016-07-28 |
2017-08-03 |
федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации |
ТЕСТ-СИСТЕМА ДЛЯ ОПРЕДЕЛЕНИЯ РНК ИНТЕРФЕРОНА λ, ИНТЕРЛЕЙКИНА IL23 И ПРОТИВОВИРУСНОГО БЕЛКА MxA
|
WO2018020012A1
(en)
|
2016-07-29 |
2018-02-01 |
Danmarks Tekniske Universitet |
Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides
|
WO2018026943A1
(en)
|
2016-08-03 |
2018-02-08 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Tlr9 targeted therapeutics
|
US11364304B2
(en)
|
2016-08-25 |
2022-06-21 |
Northwestern University |
Crosslinked micellar spherical nucleic acids
|
JOP20170056B1
(ar)
|
2016-09-02 |
2021-08-17 |
Arrowhead Pharmaceuticals Inc |
مركبات ترابطية مستهدفة
|
KR102493872B1
(ko)
|
2016-09-02 |
2023-01-30 |
다이서나 파마수이티컬, 인크. |
4'-포스페이트 유사체 및 이를 포함하는 올리고뉴클레오타이드
|
WO2018057575A1
(en)
|
2016-09-21 |
2018-03-29 |
Alnylam Pharmaceuticals, Inc |
Myostatin irna compositions and methods of use thereof
|
WO2018062510A1
(ja)
|
2016-09-29 |
2018-04-05 |
国立大学法人東京医科歯科大学 |
オーバーハングを有する二本鎖核酸複合体
|
WO2018098352A2
(en)
|
2016-11-22 |
2018-05-31 |
Jun Oishi |
Targeting kras induced immune checkpoint expression
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
EP3551641A4
(en)
|
2016-12-08 |
2021-01-13 |
University of Utah Research Foundation |
STAUFEN1 ACTIVE SUBSTANCES AND RELATED PROCEDURES
|
US20200085758A1
(en)
|
2016-12-16 |
2020-03-19 |
The Brigham And Women's Hospital, Inc. |
Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
|
EP3568482A4
(en)
|
2017-01-10 |
2020-12-16 |
Arrowhead Pharmaceuticals, Inc. |
ALPHA-1 ANTITRYPSIN (AAT) RNA INTERFERENCE (RNA) AGENTS, COMPOSITIONS CONTAINING THEM, AND PROCEDURES FOR USE THEREOF
|
WO2018146557A2
(en)
*
|
2017-02-10 |
2018-08-16 |
Dong Ki Lee |
Long double-stranded rna for rna interference
|
DE102017103383A1
(de)
|
2017-02-20 |
2018-08-23 |
aReNA-Bio GbR (vertretungsberechtigter Gesellschafter: Dr. Heribert Bohlen, 50733 Köln) |
System und Verfahren zur Zelltyp-spezifischen Translation von RNA-Molekülen in Eukaryoten
|
WO2018152524A1
(en)
*
|
2017-02-20 |
2018-08-23 |
Northwestern University |
Toxic rnai active seed sequences for killing cancer cells
|
WO2018160538A1
(en)
|
2017-02-28 |
2018-09-07 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
US11261441B2
(en)
|
2017-03-29 |
2022-03-01 |
Bluebird Bio, Inc. |
Vectors and compositions for treating hemoglobinopathies
|
CN110831544B
(zh)
|
2017-04-07 |
2022-11-18 |
阿佩利斯制药有限公司 |
长效坎普他汀类似物、其组合物的给药方案及其医药用途
|
CA3060080C
(en)
|
2017-04-14 |
2024-01-23 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Compositions and methods for treating pulmonary fibrosis
|
US11324820B2
(en)
|
2017-04-18 |
2022-05-10 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
|
WO2018209270A1
(en)
|
2017-05-11 |
2018-11-15 |
Northwestern University |
Adoptive cell therapy using spherical nucleic acids (snas)
|
WO2018218135A1
(en)
|
2017-05-25 |
2018-11-29 |
The Children's Medical Center Corporation |
Bcl11a guide delivery
|
AU2018289493A1
(en)
*
|
2017-06-20 |
2019-12-12 |
Dana-Farber Cancer Institute, Inc. |
Methods for modulating regulatory T cells, regulatory B cells, and immune responses using modulators of the APRIL-TACI interaction
|
CA3064590A1
(en)
*
|
2017-06-23 |
2018-12-27 |
University Of Massachusetts |
Two-tailed self-delivering sirna and related methods
|
US10590416B2
(en)
|
2017-07-06 |
2020-03-17 |
Arrowhead Pharmaceuticals, Inc. |
RNAi agents for inhibiting expression of alpha-ENaC and methods of use
|
EP3651775A4
(en)
|
2017-07-13 |
2021-04-07 |
Alnylam Pharmaceuticals, Inc. |
METHOD FOR INHIBITION OF HAO1 (HYDROXYIC ACID OXIDASE-1 (GLYCOLATE OXIDASE) GENE EXPRESSION
|
US11110114B2
(en)
|
2017-07-17 |
2021-09-07 |
Oxford University Innovation Limited |
Dinucleotides
|
US11104700B2
(en)
|
2017-07-17 |
2021-08-31 |
Oxford University Innovation Limited |
Oligonucleotides
|
KR20200044013A
(ko)
|
2017-09-11 |
2020-04-28 |
애로우헤드 파마슈티컬스 인코포레이티드 |
아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물
|
US11806360B2
(en)
|
2017-09-19 |
2023-11-07 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating transthyretin (TTR) mediated amyloidosis
|
WO2019068326A1
(en)
|
2017-10-05 |
2019-04-11 |
Université D'aix-Marseille |
INHIBITORS OF LSD1 FOR THE TREATMENT AND PREVENTION OF CARDIOMYOPATHIES
|
DK3684377T3
(da)
|
2017-10-20 |
2023-02-13 |
Dicerna Pharmaceuticals Inc |
Fremgangsmåder til behandling af hepatitis-b-infektion
|
US10953036B2
(en)
|
2017-11-20 |
2021-03-23 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods of modulating HIF-2A to improve muscle generation and repair
|
WO2019104289A1
(en)
|
2017-11-27 |
2019-05-31 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
MX2020005680A
(es)
|
2017-12-01 |
2020-08-20 |
Texas A & M Univ Sys |
Tratamiento antisentido del sindrome de angelman.
|
CA3083526A1
(en)
|
2017-12-06 |
2019-06-13 |
Andrew John Geall |
Compositions and methods of treating muscle atrophy and myotonic dystrophy
|
AU2018392782B2
(en)
|
2017-12-21 |
2023-08-31 |
Alnylam Pharmaceuticals, Inc. |
Chirally-enriched double-stranded RNA agents
|
EP3727463A1
(en)
|
2017-12-21 |
2020-10-28 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
US10960086B2
(en)
|
2017-12-28 |
2021-03-30 |
Augusta University Research Institute, Inc. |
Aptamer compositions and methods of use thereof
|
JP2021508477A
(ja)
|
2017-12-29 |
2021-03-11 |
オンコラス, インコーポレイテッド |
治療用ポリペプチドの腫瘍溶解性ウイルス送達
|
CA3084829A1
(en)
|
2018-01-05 |
2019-07-11 |
Dicerna Pharmaceuticals, Inc. |
Reducing beta-catenin and ido expression to potentiate immunotherapy
|
MX2020007582A
(es)
|
2018-01-16 |
2020-09-03 |
Dicerna Pharmaceuticals Inc |
Composiciones y metodos para inhibir la expresion de aldehido deshidrogenasa mitocondrial 2 (aldh2).
|
KR20200108315A
(ko)
|
2018-02-09 |
2020-09-17 |
제넨테크, 인크. |
Tmem106b의 발현을 조절하기 위한 올리고뉴클레오티드
|
EP3790991A1
(en)
|
2018-05-07 |
2021-03-17 |
Roche Innovation Center Copenhagen A/S |
Massively parallel discovery methods for oligonucleotide therapeutics
|
JP7467355B2
(ja)
|
2018-05-10 |
2024-04-15 |
コンプリメント・セラピューティクス・リミテッド |
黄斑変性症を評価するための方法
|
WO2019241734A1
(en)
*
|
2018-06-14 |
2019-12-19 |
University Of Utah Research Foundation |
Staufen1 regulating agents and associated methods
|
SG11202100715WA
(en)
|
2018-08-13 |
2021-02-25 |
Alnylam Pharmaceuticals Inc |
HEPATITIS B VIRUS (HBV) dsRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2020051231A1
(en)
|
2018-09-04 |
2020-03-12 |
H. Lee Moffitt Cancer Center & Research Institute Inc. |
Use of delta-tocotrienol for treating cancer
|
US20210317479A1
(en)
|
2018-09-06 |
2021-10-14 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
EA202191175A1
(ru)
|
2018-10-29 |
2021-09-08 |
Мерсана Терапьютикс, Инк. |
Сконструированные с цистеином конъюгаты антитело-лекарственное средство, содержащие пептидсодержащие линкеры
|
CA3128059A1
(en)
|
2019-02-12 |
2020-08-20 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for inhibiting expression of cyp27a1
|
US20220154189A1
(en)
|
2019-03-29 |
2022-05-19 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for the treatment of kras associated diseases or disorders
|
WO2020206350A1
(en)
|
2019-04-04 |
2020-10-08 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting gene expression in the central nervous system
|
US11814464B2
(en)
|
2019-04-29 |
2023-11-14 |
Yale University |
Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
|
EP3963072A1
(en)
|
2019-05-03 |
2022-03-09 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
US20200369759A1
(en)
|
2019-05-23 |
2020-11-26 |
Fibrogen, Inc. |
Methods of treatment of muscular dystrophies
|
MX2022000045A
(es)
|
2019-06-26 |
2022-04-20 |
Biorchestra Co Ltd |
Nanoparticulas micelares y sus usos.
|
MX2022002342A
(es)
|
2019-08-30 |
2022-06-14 |
Univ Yale |
Composiciones y metodos para suministro de acidos nucleicos a celulas.
|
CN114616332A
(zh)
|
2019-09-10 |
2022-06-10 |
第一三共株式会社 |
用于递送至肝脏的GalNAc-寡核苷酸偶联物及其制备方法
|
US20220389430A1
(en)
|
2019-10-02 |
2022-12-08 |
Dicema Pharmaceuticals, Inc. |
Chemical modifications of small interfering rna with minimal fluorine content
|
US11355185B2
(en)
|
2019-11-26 |
2022-06-07 |
Cypress Semiconductor Corporation |
Silicon-oxide-nitride-oxide-silicon multi-level non-volatile memory device and methods of fabrication thereof
|
MX2022007909A
(es)
|
2019-12-24 |
2022-07-21 |
Hoffmann La Roche |
Combinacion farmaceutica de agentes antivirales que actuan sobre hbv y/o un inmunomodulador para el tratamiento de hbv.
|
MX2022007908A
(es)
|
2019-12-24 |
2022-07-21 |
Hoffmann La Roche |
Combinacion farmaceutica de un oligonucleotido terapeutico que actua sobre hbv y un agonista de tlr7 para el tratamiento de hbv.
|
IL294388A
(en)
|
2020-01-14 |
2022-08-01 |
Synthekine Inc |
il2 orthologs and methods of use
|
WO2021150300A1
(en)
|
2020-01-22 |
2021-07-29 |
Massachusetts Institute Of Technology |
Inducible tissue constructs and uses thereof
|
US11642407B2
(en)
|
2020-02-28 |
2023-05-09 |
Massachusetts Institute Of Technology |
Identification of variable influenza residues and uses thereof
|
JP7398007B2
(ja)
|
2020-03-18 |
2023-12-13 |
ディセルナ ファーマシューティカルズ インコーポレイテッド |
Angptl3発現を阻害する組成物及び方法
|
JP2023537798A
(ja)
|
2020-03-19 |
2023-09-06 |
アビディティー バイオサイエンシーズ,インク. |
顔面肩甲上腕型筋ジストロフィーを処置するための組成物および方法
|
US11446387B2
(en)
|
2020-03-27 |
2022-09-20 |
Avidity Biosciences, Inc. |
Compositions and methods of treating muscle dystrophy
|
WO2021216920A1
(en)
|
2020-04-22 |
2021-10-28 |
Iovance Biotherapeutics, Inc. |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
WO2021255262A1
(en)
|
2020-06-19 |
2021-12-23 |
Sylentis Sau |
siRNA AND COMPOSITIONS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT OF VIRUS DISEASES
|
MX2022016581A
(es)
|
2020-06-19 |
2023-02-01 |
Univ Yale |
Polimeros de poli(amina-co-ester) con grupos de extremo modificado y liberacion pulmonar mejorada.
|
US20220031633A1
(en)
|
2020-07-28 |
2022-02-03 |
Yale University |
Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
|
WO2022031847A2
(en)
|
2020-08-04 |
2022-02-10 |
Dicerna Pharmaceuticals Inc. |
Compositions and methods for inhibiting plp1 expression
|
TW202221120A
(zh)
|
2020-08-04 |
2022-06-01 |
美商黛瑟納製藥公司 |
用於治療代謝症候群之組成物及方法
|
WO2022031433A1
(en)
|
2020-08-04 |
2022-02-10 |
Dicerna Pharmaceuticals, Inc. |
Systemic delivery of oligonucleotides
|
AU2021322891A1
(en)
|
2020-08-05 |
2023-03-09 |
Dicerna Pharmaceuticals, Inc. |
Oligonucleotide treatment of hepatitis B patients
|
BR112023001957A2
(pt)
|
2020-08-05 |
2023-04-25 |
Dicerna Pharmaceuticals Inc |
Composições e métodos para inibir expressão de lpa
|
WO2022047424A1
(en)
|
2020-08-31 |
2022-03-03 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
EP3964204A1
(en)
|
2020-09-08 |
2022-03-09 |
Université d'Aix-Marseille |
Lsd1 inhibitors for use in the treatment and prevention of fibrosis of tissues
|
EP4214515A1
(en)
|
2020-09-16 |
2023-07-26 |
Complement Therapeutics Limited |
Complementome assay
|
KR20230124927A
(ko)
|
2020-11-25 |
2023-08-28 |
아카제라 메디신즈, 인크. |
핵산 전달을 위한 지질 나노입자, 및 관련 사용 방법
|
CN117295753A
(zh)
|
2020-12-04 |
2023-12-26 |
基那奥生物公司 |
用于将核酸递送到细胞的组合物和方法
|
EP4015634A1
(en)
|
2020-12-15 |
2022-06-22 |
Sylentis, S.A.U. |
Sirna and compositions for prophylactic and therapeutic treatment of virus diseases
|
IL305414A
(en)
|
2021-03-04 |
2023-10-01 |
Alnylam Pharmaceuticals Inc |
Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them
|
WO2022211740A1
(en)
|
2021-03-31 |
2022-10-06 |
Carmine Therapeutics Pte. Ltd. |
Extracellular vesicles loaded with at least two different nucleic acids
|
KR20230170732A
(ko)
|
2021-04-12 |
2023-12-19 |
베링거 인겔하임 인터내셔날 게엠베하 |
케토헥소키나제 (khk)를 억제하기 위한 조성물 및 방법
|
IL307625A
(en)
|
2021-04-14 |
2023-12-01 |
Dicerna Pharmaceuticals Inc |
Compounds and methods for modulating pnpla3 expression
|
EP4326872A2
(en)
|
2021-04-19 |
2024-02-28 |
Novo Nordisk A/S |
Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression
|
BR112023023807A2
(pt)
|
2021-05-28 |
2024-02-20 |
Dicerna Pharmaceuticals Inc |
Composições e métodos para inibir a expressão do componente redutor da amidoxima mitocondrial 1 (marc1)
|
WO2022256354A1
(en)
|
2021-05-29 |
2022-12-08 |
1Globe Health Institute Llc |
Short duplex dna as a novel gene silencing technology and use thereof
|
AU2022285661A1
(en)
|
2021-05-29 |
2023-12-21 |
1Globe Health Institute Llc |
Asymmetric short duplex dna as a novel gene silencing technology and use thereof
|
WO2022271786A1
(en)
|
2021-06-23 |
2022-12-29 |
University Of Massachusetts |
Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
|
CN117795074A
(zh)
|
2021-08-03 |
2024-03-29 |
阿尔尼拉姆医药品有限公司 |
转甲状腺素蛋白(TTR)iRNA组合物和其使用方法
|
WO2023021046A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
TW202308660A
(zh)
|
2021-08-25 |
2023-03-01 |
美商戴瑟納製藥股份有限公司 |
用於抑制α-1抗胰蛋白酶表現之組合物及方法
|
CA3232054A1
(en)
|
2021-09-21 |
2023-03-30 |
Kannan Rangaramanujam |
Dendrimer conjugates of small molecule biologics for intracellular delivery
|
CA3234478A1
(en)
|
2021-11-11 |
2023-05-19 |
Souphalone LUANGSAY |
Pharmaceutical combinations for treatment of hbv
|
EP4340893A1
(en)
|
2021-11-19 |
2024-03-27 |
KIST (Korea Institute of Science and Technology) |
Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell
|
AR127843A1
(es)
|
2021-12-01 |
2024-03-06 |
Dicerna Pharmaceuticals Inc |
Composiciones y métodos para modular la expresión de apoc3
|
WO2023118546A2
(en)
|
2021-12-23 |
2023-06-29 |
Boehringer Ingelheim International Gmbh |
METHODS AND MOLECULES FOR RNA INTERFERENCE (RNAi)
|
WO2023159189A1
(en)
|
2022-02-18 |
2023-08-24 |
Yale University |
Branched poly(amine-co-ester) polymers for more efficient nucleic expression
|
GB202203627D0
(en)
|
2022-03-16 |
2022-04-27 |
Univ Manchester |
Agents for treating complement-related disorders
|
US20230302423A1
(en)
|
2022-03-28 |
2023-09-28 |
Massachusetts Institute Of Technology |
Rna scaffolded wireframe origami and methods thereof
|
GB202204884D0
(en)
|
2022-04-04 |
2022-05-18 |
Fondo Ricerca Medica S R I |
Sirna targeting kcna1
|
TW202345873A
(zh)
|
2022-04-15 |
2023-12-01 |
美商戴瑟納製藥股份有限公司 |
調節scap活性之組合物及方法
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
TW202400792A
(zh)
|
2022-05-12 |
2024-01-01 |
美商戴瑟納製藥股份有限公司 |
用於抑制mapt表現之組合物及方法
|
US20230416743A1
(en)
|
2022-05-13 |
2023-12-28 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting snca expression
|
TW202400193A
(zh)
|
2022-06-24 |
2024-01-01 |
丹麥商諾佛 儂迪克股份有限公司 |
抑制跨膜絲胺酸蛋白酶6(tmprss6)表現的組成物及方法
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
WO2024081736A2
(en)
|
2022-10-11 |
2024-04-18 |
Yale University |
Compositions and methods of using cell-penetrating antibodies
|
WO2024107993A1
(en)
|
2022-11-16 |
2024-05-23 |
Dicerna Pharmaceuticals, Inc. |
Stat3 targeting oligonucleotides and uses thereof
|
WO2024108217A1
(en)
|
2022-11-18 |
2024-05-23 |
Genkardia Inc. |
Methods and compositions for preventing, treating, or reversing cardiac diastolic dysfunction
|
WO2024112571A2
(en)
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2022-11-21 |
2024-05-30 |
Iovance Biotherapeutics, Inc. |
Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
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