DK2361981T4 - Rna-sekvensspecifikke mediatorer af rna-interferens - Google Patents

Rna-sekvensspecifikke mediatorer af rna-interferens Download PDF

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Publication number
DK2361981T4
DK2361981T4 DK10184660.8T DK10184660T DK2361981T4 DK 2361981 T4 DK2361981 T4 DK 2361981T4 DK 10184660 T DK10184660 T DK 10184660T DK 2361981 T4 DK2361981 T4 DK 2361981T4
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DK
Denmark
Prior art keywords
rna
dsrna
rnai
sequence
specific mediators
Prior art date
Application number
DK10184660.8T
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English (en)
Other versions
DK2361981T3 (da
Inventor
Thomas Tuschl
Phillip A Sharp
David P Bartel
Philip D Zamore
Original Assignee
The Whitehead Institute For Biomedical Res
Max Planck Gesellschaft
Massachusetts Inst Technology
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41655850&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2361981(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Whitehead Institute For Biomedical Res, Max Planck Gesellschaft, Massachusetts Inst Technology, Univ Massachusetts filed Critical The Whitehead Institute For Biomedical Res
Priority claimed from EP20080168152 external-priority patent/EP2028278B1/en
Application granted granted Critical
Publication of DK2361981T3 publication Critical patent/DK2361981T3/da
Publication of DK2361981T4 publication Critical patent/DK2361981T4/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK10184660.8T 2000-03-30 2001-03-30 Rna-sekvensspecifikke mediatorer af rna-interferens DK2361981T4 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19359400P 2000-03-30 2000-03-30
EP00126325 2000-12-01
US26523201P 2001-01-31 2001-01-31
EP20080168152 EP2028278B1 (en) 2000-03-30 2001-03-30 RNA sequence-specific mediators of RNA interference

Publications (2)

Publication Number Publication Date
DK2361981T3 DK2361981T3 (da) 2013-06-24
DK2361981T4 true DK2361981T4 (da) 2019-05-13

Family

ID=41655850

Family Applications (7)

Application Number Title Priority Date Filing Date
DK10184660.8T DK2361981T4 (da) 2000-03-30 2001-03-30 Rna-sekvensspecifikke mediatorer af rna-interferens
DK10184711.9T DK2345742T3 (da) 2000-03-30 2001-03-30 RNA-sekvensspecifikke formidlere af RNA-interferens
DK08168152.0T DK2028278T3 (da) 2000-03-30 2001-03-30 RNA-sekvensspecifikke formidlere af RNA-interferens
DK10184520.4T DK2360253T3 (da) 2000-03-30 2001-03-30 Fremgangsmåde til fremstilling af knockdown-celler eller knockdown-organismer ved hjælp af RNA-sekvensspecifikke formidlere af RNA-interferens og anvendelser deraf
DK10179952.6T DK2348133T3 (da) 2000-12-01 2001-11-29 Små RNA-molekyler, som formidler RNA-interferens
DK10179947.6T DK2351852T4 (da) 2000-12-01 2001-11-29 Små RNA-molekyler, som medierer RNA-interferens
DK10180025.8T DK2348134T3 (da) 2000-12-01 2001-11-29 Små RNA-molekyler, som formidler RNA-interferens

Family Applications After (6)

Application Number Title Priority Date Filing Date
DK10184711.9T DK2345742T3 (da) 2000-03-30 2001-03-30 RNA-sekvensspecifikke formidlere af RNA-interferens
DK08168152.0T DK2028278T3 (da) 2000-03-30 2001-03-30 RNA-sekvensspecifikke formidlere af RNA-interferens
DK10184520.4T DK2360253T3 (da) 2000-03-30 2001-03-30 Fremgangsmåde til fremstilling af knockdown-celler eller knockdown-organismer ved hjælp af RNA-sekvensspecifikke formidlere af RNA-interferens og anvendelser deraf
DK10179952.6T DK2348133T3 (da) 2000-12-01 2001-11-29 Små RNA-molekyler, som formidler RNA-interferens
DK10179947.6T DK2351852T4 (da) 2000-12-01 2001-11-29 Små RNA-molekyler, som medierer RNA-interferens
DK10180025.8T DK2348134T3 (da) 2000-12-01 2001-11-29 Små RNA-molekyler, som formidler RNA-interferens

Country Status (11)

Country Link
EP (7) EP2360253B1 (da)
CN (2) CN101654672B (da)
AT (1) ATE542899T1 (da)
BR (4) BRPI0117341B1 (da)
CA (1) CA2791831C (da)
DK (7) DK2361981T4 (da)
ES (9) ES2461765T3 (da)
LT (1) LT2813582T (da)
PL (1) PL218881B1 (da)
PT (8) PT2345742E (da)
SI (4) SI2348133T1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2404890C (en) 2000-03-30 2013-11-19 Whitehead Institute For Biomedical Research Rna sequence-specific mediators of rna interference
CZ302719B6 (cs) 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
EP1478656B1 (en) 2002-02-01 2009-09-16 Life Technologies Corporation Oligonucleotide compositions with enhanced efficiency
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
MA45470A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques kras et leurs utilisations
MA45349A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques egfr et leurs utilisations
MA45469A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques de bêta-caténine et leurs utilisations
DE102018001134A1 (de) * 2017-06-26 2018-12-27 Martin-Luther-Universität Halle-Wittenberg Methode zur gezielten Identifizierung hocheffizienter "small interfering RNAs" ("eRNAs") zur Anwendung in Pflanzen und anderen Zielorganismen
IL319835A (en) 2017-12-06 2025-05-01 Avidity Biosciences Inc Compositions and methods for treating muscular dystrophy and myotonic dystrophy
IL296387B2 (en) 2020-03-19 2024-08-01 Avidity Biosciences Inc Preparations and methods for the treatment of facial, back and arm muscle atrophy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59198885A (ja) 1983-04-25 1984-11-10 Nec Corp 圧電アクチェータ励振回路
US5652355A (en) † 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
CA2176259A1 (en) † 1993-11-16 1995-05-26 Lyle J. Arnold, Jr. Chimeric oligonucleoside compounds
US6506559B1 (en) † 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
JP2003525017A (ja) † 1998-04-20 2003-08-26 リボザイム・ファーマシューティカルズ・インコーポレーテッド 遺伝子発現を調節しうる新規な化学組成を有する核酸分子
DE19956568A1 (de) † 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
AU2001245793A1 (en) * 2000-03-16 2001-09-24 Cold Spring Harbor Laboratory Methods and compositions for rna interference
CA2404890C (en) * 2000-03-30 2013-11-19 Whitehead Institute For Biomedical Research Rna sequence-specific mediators of rna interference
CZ302719B6 (cs) * 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití

Also Published As

Publication number Publication date
SI2813582T1 (sl) 2017-08-31
PT2813582T (pt) 2017-07-17
EP2351852B2 (en) 2020-07-01
BRPI0117338B1 (pt) 2016-06-21
EP2361981B2 (en) 2019-01-23
CN101654673A (zh) 2010-02-24
DK2348134T3 (da) 2014-07-14
PT2360253E (pt) 2014-05-29
LT2813582T (lt) 2017-07-25
BRPI0117341B1 (pt) 2016-06-21
EP2361981B1 (en) 2013-03-06
DK2360253T3 (da) 2014-06-16
EP2360253A1 (en) 2011-08-24
ES2380171T3 (es) 2012-05-09
ES2410907T5 (es) 2019-08-20
CN101654672A (zh) 2010-02-24
PT2345742E (pt) 2014-09-03
ES2632957T3 (es) 2017-09-18
EP2796553B1 (en) 2019-06-19
SI2348133T1 (sl) 2014-11-28
EP3199631A1 (en) 2017-08-02
ES2437390T3 (es) 2014-01-10
DK2351852T3 (da) 2014-01-06
DK2345742T3 (da) 2014-09-15
EP2351852A1 (en) 2011-08-03
PL218881B1 (pl) 2015-02-27
ATE542899T1 (de) 2012-02-15
DK2348133T3 (da) 2014-10-13
ES2437390T5 (es) 2021-02-05
SI2348134T1 (sl) 2014-08-29
BRPI0117339B1 (pt) 2016-03-15
DK2351852T4 (da) 2020-08-24
EP2348134A1 (en) 2011-07-27
BRPI0117338A2 (pt) 2011-08-02
PT2351852E (pt) 2014-01-03
EP2348134B1 (en) 2014-04-16
ES2500923T3 (es) 2014-10-01
BRPI0117340B1 (pt) 2016-10-18
PT2028278E (pt) 2014-05-28
PT2348133E (pt) 2014-10-14
EP2361981A1 (en) 2011-08-31
ES2410907T3 (es) 2013-07-03
SI2351852T1 (sl) 2013-12-31
BRPI0117341A2 (pt) 2011-08-02
ES2461765T3 (es) 2014-05-21
PT2348134E (pt) 2014-07-16
EP2360253B1 (en) 2014-03-19
CA2791831C (en) 2015-06-23
EP3199631B1 (en) 2019-01-30
PT2361981E (pt) 2013-06-12
EP2796553A1 (en) 2014-10-29
ES2462716T3 (es) 2014-05-26
EP2351852B1 (en) 2013-10-02
CN101643789B (zh) 2013-04-24
CA2791831A1 (en) 2002-06-06
ES2498747T3 (es) 2014-09-25
DK2028278T3 (da) 2014-06-23
DK2361981T3 (da) 2013-06-24
CN101643789A (zh) 2010-02-10
EP2813582B1 (en) 2017-04-12
ES2461715T3 (es) 2014-05-21
SI2351852T2 (sl) 2020-10-30
CN101654672B (zh) 2013-06-05
EP2813582A1 (en) 2014-12-17

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