PT2028278E - Mediadores de interferência por rna específicos de sequência de rna - Google Patents

Mediadores de interferência por rna específicos de sequência de rna Download PDF

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Publication number
PT2028278E
PT2028278E PT81681520T PT08168152T PT2028278E PT 2028278 E PT2028278 E PT 2028278E PT 81681520 T PT81681520 T PT 81681520T PT 08168152 T PT08168152 T PT 08168152T PT 2028278 E PT2028278 E PT 2028278E
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PT
Portugal
Prior art keywords
rna
dsrna
sequence
rnai
specific mediators
Prior art date
Application number
PT81681520T
Other languages
English (en)
Inventor
Thomas Tuschl
Phillip A Sharp
Phillip D Zamore
David P Bartel
Original Assignee
Max Planck Ges Zur Förderung Der Wissenschaften E V
Whitehead Biomedical Inst
Massachusetts Inst Technology
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41655850&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2028278(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Max Planck Ges Zur Förderung Der Wissenschaften E V, Whitehead Biomedical Inst, Massachusetts Inst Technology, Univ Massachusetts filed Critical Max Planck Ges Zur Förderung Der Wissenschaften E V
Publication of PT2028278E publication Critical patent/PT2028278E/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT81681520T 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna PT2028278E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19359400P 2000-03-30 2000-03-30
EP00126325 2000-12-01
US26523201P 2001-01-31 2001-01-31

Publications (1)

Publication Number Publication Date
PT2028278E true PT2028278E (pt) 2014-05-28

Family

ID=41655850

Family Applications (8)

Application Number Title Priority Date Filing Date
PT101846608T PT2361981E (pt) 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna
PT101847119T PT2345742E (pt) 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna
PT101845204T PT2360253E (pt) 2000-03-30 2001-03-30 Métodos de produção de células ou organismos knockdown através de interferência por rna com mediadores de rna específicos de sequência e usos dos mesmos
PT81681520T PT2028278E (pt) 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna
PT141766055T PT2813582T (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn
PT101799476T PT2351852E (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn
PT101800258T PT2348134E (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn
PT101799526T PT2348133E (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PT101846608T PT2361981E (pt) 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna
PT101847119T PT2345742E (pt) 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna
PT101845204T PT2360253E (pt) 2000-03-30 2001-03-30 Métodos de produção de células ou organismos knockdown através de interferência por rna com mediadores de rna específicos de sequência e usos dos mesmos

Family Applications After (4)

Application Number Title Priority Date Filing Date
PT141766055T PT2813582T (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn
PT101799476T PT2351852E (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn
PT101800258T PT2348134E (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn
PT101799526T PT2348133E (pt) 2000-12-01 2001-11-29 Moléculas curtas de arn que medeiam a interferência de arn

Country Status (11)

Country Link
EP (7) EP2796553B1 (pt)
CN (2) CN101643789B (pt)
AT (1) ATE542899T1 (pt)
BR (4) BRPI0117341B1 (pt)
CA (1) CA2791831C (pt)
DK (7) DK2345742T3 (pt)
ES (9) ES2461765T3 (pt)
LT (1) LT2813582T (pt)
PL (1) PL218881B1 (pt)
PT (8) PT2361981E (pt)
SI (4) SI2348134T1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001249622B2 (en) 2000-03-30 2007-06-07 Massachusetts Institute Of Technology RNA sequence-specific mediators of RNA interference
WO2002044321A2 (en) 2000-12-01 2002-06-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Rna interference mediating small rna molecules
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US20040014956A1 (en) 2002-02-01 2004-01-22 Sequitur, Inc. Double-stranded oligonucleotides
MA45470A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques kras et leurs utilisations
MA45469A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques de bêta-caténine et leurs utilisations
MA45349A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques egfr et leurs utilisations
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
DE102018001134A1 (de) * 2017-06-26 2018-12-27 Martin-Luther-Universität Halle-Wittenberg Methode zur gezielten Identifizierung hocheffizienter "small interfering RNAs" ("eRNAs") zur Anwendung in Pflanzen und anderen Zielorganismen
MX2020005860A (es) 2017-12-06 2020-09-09 Avidity Biosciences Inc Composiciones y metodos de tratamiento de atrofia muscular y distrofia miotonica.
CA3172111A1 (en) 2020-03-19 2021-09-23 Barbora MALECOVA Compositions and methods of treating facioscapulohumeral muscular dystrophy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59198885A (ja) 1983-04-25 1984-11-10 Nec Corp 圧電アクチェータ励振回路
US5652355A (en) † 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
EP0743859A4 (en) † 1993-11-16 1998-10-21 Genta Inc CHEMICAL OLIGONUCLEOSIDE COMPOUNDS
US6506559B1 (en) † 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP1071753A2 (en) † 1998-04-20 2001-01-31 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
JP2003526367A (ja) * 2000-03-16 2003-09-09 ジェネティカ インコーポレイテッド Ｒｎａ干渉の方法とｒｎａ干渉組成物
AU2001249622B2 (en) * 2000-03-30 2007-06-07 Massachusetts Institute Of Technology RNA sequence-specific mediators of RNA interference
WO2002044321A2 (en) * 2000-12-01 2002-06-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Rna interference mediating small rna molecules

Also Published As

Publication number Publication date
BRPI0117340B1 (pt) 2016-10-18
ES2410907T3 (es) 2013-07-03
EP2360253A1 (en) 2011-08-24
CA2791831C (en) 2015-06-23
CN101654672B (zh) 2013-06-05
BRPI0117338A2 (pt) 2011-08-02
CN101643789A (zh) 2010-02-10
SI2351852T2 (sl) 2020-10-30
SI2351852T1 (sl) 2013-12-31
ATE542899T1 (de) 2012-02-15
EP3199631A1 (en) 2017-08-02
DK2360253T3 (da) 2014-06-16
ES2462716T3 (es) 2014-05-26
EP2351852B1 (en) 2013-10-02
DK2348133T3 (da) 2014-10-13
ES2437390T5 (es) 2021-02-05
EP2361981B1 (en) 2013-03-06
SI2348134T1 (sl) 2014-08-29
ES2498747T3 (es) 2014-09-25
ES2461715T3 (es) 2014-05-21
DK2361981T4 (da) 2019-05-13
SI2813582T1 (sl) 2017-08-31
PT2348133E (pt) 2014-10-14
EP2348134A1 (en) 2011-07-27
PL218881B1 (pl) 2015-02-27
PT2351852E (pt) 2014-01-03
DK2345742T3 (da) 2014-09-15
EP2813582A1 (en) 2014-12-17
DK2028278T3 (da) 2014-06-23
ES2410907T5 (es) 2019-08-20
DK2351852T4 (da) 2020-08-24
EP2796553A1 (en) 2014-10-29
CA2791831A1 (en) 2002-06-06
EP3199631B1 (en) 2019-01-30
PT2361981E (pt) 2013-06-12
BRPI0117341B1 (pt) 2016-06-21
PT2345742E (pt) 2014-09-03
EP2351852A1 (en) 2011-08-03
ES2380171T3 (es) 2012-05-09
EP2813582B1 (en) 2017-04-12
ES2437390T3 (es) 2014-01-10
EP2351852B2 (en) 2020-07-01
ES2461765T3 (es) 2014-05-21
ES2632957T3 (es) 2017-09-18
PT2348134E (pt) 2014-07-16
DK2348134T3 (da) 2014-07-14
CN101654672A (zh) 2010-02-24
DK2361981T3 (da) 2013-06-24
PT2813582T (pt) 2017-07-17
PT2360253E (pt) 2014-05-29
EP2361981B2 (en) 2019-01-23
EP2360253B1 (en) 2014-03-19
DK2351852T3 (da) 2014-01-06
EP2361981A1 (en) 2011-08-31
BRPI0117338B1 (pt) 2016-06-21
EP2348134B1 (en) 2014-04-16
SI2348133T1 (sl) 2014-11-28
BRPI0117341A2 (pt) 2011-08-02
BRPI0117339B1 (pt) 2016-03-15
CN101643789B (zh) 2013-04-24
EP2796553B1 (en) 2019-06-19
ES2500923T3 (es) 2014-10-01
LT2813582T (lt) 2017-07-25
CN101654673A (zh) 2010-02-24

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