PT2351852E - Moléculas curtas de arn que medeiam a interferência de arn - Google Patents
Moléculas curtas de arn que medeiam a interferência de arn Download PDFInfo
- Publication number
- PT2351852E PT2351852E PT101799476T PT10179947T PT2351852E PT 2351852 E PT2351852 E PT 2351852E PT 101799476 T PT101799476 T PT 101799476T PT 10179947 T PT10179947 T PT 10179947T PT 2351852 E PT2351852 E PT 2351852E
- Authority
- PT
- Portugal
- Prior art keywords
- rna
- dsrna
- rnai
- sequence
- target rna
- Prior art date
Links
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 title abstract 4
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 4
- 108091032955 Bacterial small RNA Proteins 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 6
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 4
- 108020004459 Small interfering RNA Proteins 0.000 abstract 4
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 abstract 1
- 230000007022 RNA scission Effects 0.000 abstract 1
- 102000006382 Ribonucleases Human genes 0.000 abstract 1
- 108010083644 Ribonucleases Proteins 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000006166 lysate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000032361 posttranscriptional gene silencing Effects 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00126325 | 2000-12-01 | ||
US27966101P | 2001-03-30 | 2001-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2351852E true PT2351852E (pt) | 2014-01-03 |
Family
ID=41655850
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT101846608T PT2361981E (pt) | 2000-03-30 | 2001-03-30 | Mediadores de interferência por rna específicos de sequência de rna |
PT101847119T PT2345742E (pt) | 2000-03-30 | 2001-03-30 | Mediadores de interferência por rna específicos de sequência de rna |
PT101845204T PT2360253E (pt) | 2000-03-30 | 2001-03-30 | Métodos de produção de células ou organismos knockdown através de interferência por rna com mediadores de rna específicos de sequência e usos dos mesmos |
PT81681520T PT2028278E (pt) | 2000-03-30 | 2001-03-30 | Mediadores de interferência por rna específicos de sequência de rna |
PT141766055T PT2813582T (pt) | 2000-12-01 | 2001-11-29 | Moléculas curtas de arn que medeiam a interferência de arn |
PT101799476T PT2351852E (pt) | 2000-12-01 | 2001-11-29 | Moléculas curtas de arn que medeiam a interferência de arn |
PT101800258T PT2348134E (pt) | 2000-12-01 | 2001-11-29 | Moléculas curtas de arn que medeiam a interferência de arn |
PT101799526T PT2348133E (pt) | 2000-12-01 | 2001-11-29 | Moléculas curtas de arn que medeiam a interferência de arn |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT101846608T PT2361981E (pt) | 2000-03-30 | 2001-03-30 | Mediadores de interferência por rna específicos de sequência de rna |
PT101847119T PT2345742E (pt) | 2000-03-30 | 2001-03-30 | Mediadores de interferência por rna específicos de sequência de rna |
PT101845204T PT2360253E (pt) | 2000-03-30 | 2001-03-30 | Métodos de produção de células ou organismos knockdown através de interferência por rna com mediadores de rna específicos de sequência e usos dos mesmos |
PT81681520T PT2028278E (pt) | 2000-03-30 | 2001-03-30 | Mediadores de interferência por rna específicos de sequência de rna |
PT141766055T PT2813582T (pt) | 2000-12-01 | 2001-11-29 | Moléculas curtas de arn que medeiam a interferência de arn |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT101800258T PT2348134E (pt) | 2000-12-01 | 2001-11-29 | Moléculas curtas de arn que medeiam a interferência de arn |
PT101799526T PT2348133E (pt) | 2000-12-01 | 2001-11-29 | Moléculas curtas de arn que medeiam a interferência de arn |
Country Status (11)
Country | Link |
---|---|
EP (7) | EP2796553B1 (pt) |
CN (2) | CN101643789B (pt) |
AT (1) | ATE542899T1 (pt) |
BR (4) | BRPI0117341B1 (pt) |
CA (1) | CA2791831C (pt) |
DK (7) | DK2345742T3 (pt) |
ES (9) | ES2461765T3 (pt) |
LT (1) | LT2813582T (pt) |
PL (1) | PL218881B1 (pt) |
PT (8) | PT2361981E (pt) |
SI (4) | SI2348134T1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001249622B2 (en) | 2000-03-30 | 2007-06-07 | Massachusetts Institute Of Technology | RNA sequence-specific mediators of RNA interference |
WO2002044321A2 (en) | 2000-12-01 | 2002-06-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Rna interference mediating small rna molecules |
US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
US20040014956A1 (en) | 2002-02-01 | 2004-01-22 | Sequitur, Inc. | Double-stranded oligonucleotides |
MA45470A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques kras et leurs utilisations |
MA45469A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques de bêta-caténine et leurs utilisations |
MA45349A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques egfr et leurs utilisations |
MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
DE102018001134A1 (de) * | 2017-06-26 | 2018-12-27 | Martin-Luther-Universität Halle-Wittenberg | Methode zur gezielten Identifizierung hocheffizienter "small interfering RNAs" ("eRNAs") zur Anwendung in Pflanzen und anderen Zielorganismen |
MX2020005860A (es) | 2017-12-06 | 2020-09-09 | Avidity Biosciences Inc | Composiciones y metodos de tratamiento de atrofia muscular y distrofia miotonica. |
CA3172111A1 (en) | 2020-03-19 | 2021-09-23 | Barbora MALECOVA | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59198885A (ja) | 1983-04-25 | 1984-11-10 | Nec Corp | 圧電アクチェータ励振回路 |
US5652355A (en) † | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
EP0743859A4 (en) † | 1993-11-16 | 1998-10-21 | Genta Inc | CHEMICAL OLIGONUCLEOSIDE COMPOUNDS |
US6506559B1 (en) † | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
EP1071753A2 (en) † | 1998-04-20 | 2001-01-31 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
JP2003526367A (ja) * | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Rna干渉の方法とrna干渉組成物 |
AU2001249622B2 (en) * | 2000-03-30 | 2007-06-07 | Massachusetts Institute Of Technology | RNA sequence-specific mediators of RNA interference |
WO2002044321A2 (en) * | 2000-12-01 | 2002-06-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Rna interference mediating small rna molecules |
-
2001
- 2001-03-30 PT PT101846608T patent/PT2361981E/pt unknown
- 2001-03-30 BR BRPI0117341A patent/BRPI0117341B1/pt active IP Right Grant
- 2001-03-30 ES ES10184520.4T patent/ES2461765T3/es not_active Expired - Lifetime
- 2001-03-30 BR BRPI0117339A patent/BRPI0117339B1/pt active IP Right Grant
- 2001-03-30 DK DK10184711.9T patent/DK2345742T3/da active
- 2001-03-30 EP EP14164227.2A patent/EP2796553B1/en not_active Expired - Lifetime
- 2001-03-30 PT PT101847119T patent/PT2345742E/pt unknown
- 2001-03-30 EP EP10184660.8A patent/EP2361981B2/en not_active Expired - Lifetime
- 2001-03-30 ES ES10184711.9T patent/ES2500923T3/es not_active Expired - Lifetime
- 2001-03-30 PT PT101845204T patent/PT2360253E/pt unknown
- 2001-03-30 BR BRPI0117338A patent/BRPI0117338B1/pt active IP Right Grant
- 2001-03-30 EP EP10184520.4A patent/EP2360253B1/en not_active Expired - Lifetime
- 2001-03-30 BR BRPI0117340A patent/BRPI0117340B1/pt active IP Right Grant
- 2001-03-30 ES ES10184660T patent/ES2410907T5/es not_active Expired - Lifetime
- 2001-03-30 DK DK10184520.4T patent/DK2360253T3/da active
- 2001-03-30 PT PT81681520T patent/PT2028278E/pt unknown
- 2001-03-30 DK DK08168152.0T patent/DK2028278T3/da active
- 2001-03-30 ES ES08168152.0T patent/ES2461715T3/es not_active Expired - Lifetime
- 2001-03-30 DK DK10184660.8T patent/DK2361981T4/da active
- 2001-11-29 DK DK10180025.8T patent/DK2348134T3/da active
- 2001-11-29 ES ES14176605.5T patent/ES2632957T3/es not_active Expired - Lifetime
- 2001-11-29 SI SI200131034T patent/SI2348134T1/sl unknown
- 2001-11-29 DK DK10179947.6T patent/DK2351852T4/da active
- 2001-11-29 ES ES10179952.6T patent/ES2498747T3/es not_active Expired - Lifetime
- 2001-11-29 PL PL384789A patent/PL218881B1/pl unknown
- 2001-11-29 AT AT07014533T patent/ATE542899T1/de active
- 2001-11-29 SI SI200131035T patent/SI2348133T1/sl unknown
- 2001-11-29 PT PT141766055T patent/PT2813582T/pt unknown
- 2001-11-29 ES ES07014533T patent/ES2380171T3/es not_active Expired - Lifetime
- 2001-11-29 PT PT101799476T patent/PT2351852E/pt unknown
- 2001-11-29 EP EP14176605.5A patent/EP2813582B1/en not_active Expired - Lifetime
- 2001-11-29 SI SI200131063T patent/SI2813582T1/sl unknown
- 2001-11-29 ES ES10179947T patent/ES2437390T5/es not_active Expired - Lifetime
- 2001-11-29 SI SI200131028T patent/SI2351852T2/sl unknown
- 2001-11-29 EP EP10180025.8A patent/EP2348134B1/en not_active Expired - Lifetime
- 2001-11-29 CN CN2009101488863A patent/CN101643789B/zh not_active Expired - Lifetime
- 2001-11-29 LT LTEP14176605.5T patent/LT2813582T/lt unknown
- 2001-11-29 EP EP17160119.8A patent/EP3199631B1/en not_active Expired - Lifetime
- 2001-11-29 PT PT101800258T patent/PT2348134E/pt unknown
- 2001-11-29 PT PT101799526T patent/PT2348133E/pt unknown
- 2001-11-29 ES ES10180025.8T patent/ES2462716T3/es not_active Expired - Lifetime
- 2001-11-29 CN CN2009101488878A patent/CN101654672B/zh not_active Expired - Lifetime
- 2001-11-29 CA CA2791831A patent/CA2791831C/en not_active Expired - Lifetime
- 2001-11-29 EP EP10179947.6A patent/EP2351852B2/en not_active Expired - Lifetime
- 2001-11-29 DK DK10179952.6T patent/DK2348133T3/da active
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