HRP20221191T1 - Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene - Google Patents
Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene Download PDFInfo
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- HRP20221191T1 HRP20221191T1 HRP20221191TT HRP20221191T HRP20221191T1 HR P20221191 T1 HRP20221191 T1 HR P20221191T1 HR P20221191T T HRP20221191T T HR P20221191TT HR P20221191 T HRP20221191 T HR P20221191T HR P20221191 T1 HRP20221191 T1 HR P20221191T1
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- 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 title 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 title 1
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 claims 43
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 8
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 7
- 230000028993 immune response Effects 0.000 claims 5
- 230000004936 stimulating effect Effects 0.000 claims 3
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 101150030213 Lag3 gene Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 208000009060 clear cell adenocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (26)
1. Anti-LAG-3 antitijelo i dodatno imunostimulatorno antitijelo za primjenu u postupku stimuliranja imunog odgovora kod pojedinca, pri čemu postupak obuhvaća administriranje pojedincu anti-LAG-3 antitijela i dodatnog imunostimulatornog antitijela, i pri čemu dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo, anti-PD-L1 antitijelo, ili anti-CTLA-4 antitijelo.
2. Anti-LAG-3 antitijelo za primjenu u postupku stimuliranja imunog odgovora kod pojedinca, pri čemu postupak obuhvaća administriranje pojedincu anti-LAG-3 antitijela i dodatnog imunostimulatornog antitijela, i pri čemu dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo, anti-PD-L1 antitijelo, ili anti-CTLA-4 antitijelo.
3. Imunostimulatorno antitijelo za primjenu u postupku stimuliranja imunog odgovora kod pojedinca, pri čemu postupak obuhvaća administriranje pojedincu imunostimulatornog antitijela dodatno anti-LAG-3 antitijelu, i pri čemu dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo, anti-PD-L1 antitijelo, ili anti-CTLA-4 antitijelo.
4. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-3, pri čemu imuni odgovor je antigen-specifičan T stanični odgovor.
5. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-4, pri čemu imuni odgovor je protiv tumora.
6. Anti-LAG-3 antitijelo i dodatno imunostimulatorno antitijelo za primjenu u postupku liječenja raka kod pojedinca koji obuhvaća administriranje pojedincu anti-LAG-3 antitijela i dodatnog imunostimulatornog antitijela, i pri čemu dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo, anti-PD-L1 antitijelo, ili anti-CTLA-4 antitijelo.
7. Anti-LAG-3 antitijelo za primjenu u postupku liječenja raka kod pojedinca koji obuhvaća administriranje pojedincu anti-LAG-3 antitijela i dodatnog imunostimulatornog antitijela, i pri čemu dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo, anti-PD-L1 antitijelo, ili anti-CTLA-4 antitijelo.
8. Imunostimulatorno antitijelo za primjenu u postupku liječenja raka kod pojedinca koji obuhvaća administriranje pojedincu imunostimulatornog antitijela dodatno anti-LAG-3 antitijelu, i pri čemu dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo, anti-PD-L1 antitijelo, ili anti-CTLA-4 antitijelo.
9. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 6-8, pri čemu rak je metastatski rak.
10. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 6-8, pri čemu rak je refraktorni ili rekurentni malignitet.
11. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 6-8, pri čemu rak je melanom (npr, metastatski maligni melanom), renalni rak (npr. karcinom svijetlih stanica), rak prostate (npr. hormonski refraktoran adenokarcinom prostate), rak dojke, rak debelog crijeva, ili pluća (npr. nesitnostanični rak pluća).
12. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 6-10, pri čemu rak je kutani ili intraokularni maligni melanom.
13. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-12, pri čemu anti-LAG-3 antitijelo ima sposobnost inhibiranja vezivanje LAG-3 za molekule glavne histokompatibilnosti (MHC) klase II
14. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-13, pri čemu anti-LAG-3 antitijelo ima sposobnost stimuliranja proizvodnje interleukina-2 (IL-2) u antigen-specifičnom T staničnom odgovoru
15. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-14, pri čemu anti-LAG-3 antitijelo je humano, himerno ili humanizirano antitijelo.
16. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-15, pri čemu anti-LAG-3 antitijelo je IgG4 izotip.
17. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-16, pri čemu dodatno imunostimulatorno antitijelo je humano, himerno ili humanizirano antitijelo.
18. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-17, pri čemu dodatno imunostimulatorno antitijelo je anti-PD-1 antitijelo.
19. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-17, pri čemu dodatno imunostimulatorno antitijelo je anti-PD-L1 antitijelo.
20. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-17, pri čemu dodatno imunostimulatorno antitijelo je anti-CTLA-4 antitijelo.
21. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-20, pri čemu anti-LAG-3 antitijelo je zajednički administrirano sa dodatnim imunostimulatornim antitijelom.
22. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-20, pri čemu su anti-LAG-3 antitijelo i dodatno imunostimulatorno antitijelo administrirani istovremeno kao jedna kompozicija u farmaceutski prihvatljivom nosaču, ili istovremeno kao zasebne kompozicije sa svakim antitijelom u farmaceutski prihvatljivom nosaču.
23. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-20, pri čemu anti-LAG-3 antitijelo i dodatno imunostimulatorno antitijelo su administrirani sekvencijalno.
24. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-23, koja dalje obuhvaća administriranje kemoterapijskog agensa.
25. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-23, koja dalje obuhvaća zračenje, operaciju, ili hormonsku deprivaciju.
26. Anti-LAG-3 antitijelo i/ili imunostimulatorno antitijelo za primjenu iz bilo kojeg od patentnih zahtjeva 1-23, koja dalje obuhvaća administriranje inhibitora angiogeneze.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18854808P | 2008-08-11 | 2008-08-11 | |
EP19186310.9A EP3597216B1 (en) | 2008-08-11 | 2009-08-11 | Human antibodies that bind lymphocyte activation gene-3 (lag-3) and uses thereof |
Publications (1)
Publication Number | Publication Date |
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HRP20221191T1 true HRP20221191T1 (hr) | 2022-12-09 |
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ID=41669613
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20221191TT HRP20221191T1 (hr) | 2008-08-11 | 2009-08-11 | Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene |
HRP20150453TT HRP20150453T1 (hr) | 2008-08-11 | 2015-04-27 | Humana antitijela koja vežu gen aktivacije limfocita 3 (lag-3) i njihova primjena |
HRP20200070TT HRP20200070T8 (hr) | 2008-08-11 | 2020-01-17 | Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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HRP20150453TT HRP20150453T1 (hr) | 2008-08-11 | 2015-04-27 | Humana antitijela koja vežu gen aktivacije limfocita 3 (lag-3) i njihova primjena |
HRP20200070TT HRP20200070T8 (hr) | 2008-08-11 | 2020-01-17 | Humana antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3) i njihove primjene |
Country Status (32)
Country | Link |
---|---|
US (13) | US20110150892A1 (hr) |
EP (4) | EP2905030B1 (hr) |
JP (6) | JP5647981B2 (hr) |
KR (6) | KR101700459B1 (hr) |
CN (4) | CN113773386A (hr) |
AR (3) | AR072999A1 (hr) |
AU (2) | AU2009282134B2 (hr) |
BR (1) | BRPI0917470B8 (hr) |
CA (1) | CA2734335C (hr) |
CL (4) | CL2011000308A1 (hr) |
CO (1) | CO6351751A2 (hr) |
CY (2) | CY1116582T1 (hr) |
DK (3) | DK2905030T3 (hr) |
EA (2) | EA201590777A1 (hr) |
ES (3) | ES2927547T3 (hr) |
HK (2) | HK1151985A1 (hr) |
HR (3) | HRP20221191T1 (hr) |
HU (2) | HUE060029T2 (hr) |
IL (4) | IL210731A (hr) |
LT (2) | LT3597216T (hr) |
MX (2) | MX2011001250A (hr) |
NZ (3) | NZ602780A (hr) |
PE (3) | PE20190373A1 (hr) |
PL (3) | PL3597216T3 (hr) |
PT (3) | PT3597216T (hr) |
SG (1) | SG10201706497QA (hr) |
SI (2) | SI2320940T1 (hr) |
SM (1) | SMT201500125B (hr) |
TN (1) | TN2011000025A1 (hr) |
TW (1) | TWI491408B (hr) |
WO (1) | WO2010019570A2 (hr) |
ZA (1) | ZA201101009B (hr) |
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KR101373464B1 (ko) | 2005-12-08 | 2014-03-14 | 메다렉스, 엘.엘.시. | 단백질 티로신 키나제 7(ptk7)에 대한 인간 단일클론항체 및 그의 용도 |
AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
JP6278598B2 (ja) | 2010-11-30 | 2018-02-14 | 中外製薬株式会社 | 細胞傷害誘導治療剤 |
JP6029470B2 (ja) * | 2010-12-06 | 2016-11-24 | 大日本住友製薬株式会社 | ヒトモノクローナル抗体 |
US8440797B2 (en) | 2010-12-06 | 2013-05-14 | Dainippon Sumitomo Pharma Co., Ltd. | Human monoclonal antibody |
US9428567B2 (en) | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
ES2694749T3 (es) * | 2011-06-30 | 2018-12-27 | Genzyme Corporation | Inhibidores de la activación de células T |
JP6105578B2 (ja) | 2011-07-21 | 2017-03-29 | トレロ ファーマシューティカルズ, インコーポレイテッド | 複素環式プロテインキナーゼ阻害剤 |
AR091649A1 (es) * | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
CN105209494B (zh) | 2013-03-15 | 2019-04-09 | 葛兰素史克知识产权开发有限公司 | 抗lag-3结合蛋白 |
EP3404116B1 (en) | 2013-03-15 | 2022-10-19 | The University of Chicago | Methods and compositions related to t-cell activity |
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