MX2023002884A - Vacuna heterologa de estimulo primario. - Google Patents

Vacuna heterologa de estimulo primario.

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Publication number
MX2023002884A
MX2023002884A MX2023002884A MX2023002884A MX2023002884A MX 2023002884 A MX2023002884 A MX 2023002884A MX 2023002884 A MX2023002884 A MX 2023002884A MX 2023002884 A MX2023002884 A MX 2023002884A MX 2023002884 A MX2023002884 A MX 2023002884A
Authority
MX
Mexico
Prior art keywords
component
antigenic domain
vaccine
prime boost
heterologous prime
Prior art date
Application number
MX2023002884A
Other languages
English (en)
Inventor
Madiha Derouazi
Elodie Belnoue
Guido Wollmann
Krishna Das
Knut Elbers
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2023002884A publication Critical patent/MX2023002884A/es

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    • A—HUMAN NECESSITIES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/766—Rhabdovirus, e.g. vesicular stomatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
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    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

La presente invención se refiere a la provisión de una vacuna que comprende un primer componente (K) y un segundo componente (V), en donde el primer componente (K) comprende un complejo en el que un péptido de penetración celular, un dominio antigénico y un agonista de TLR están unidos funcionalmente y el segundo componente (V) comprende un virus de la estomatitis vesicular recombinante oncolítico que expresa un dominio antigénico. La invención se refiere además al uso de la vacuna inventiva en el tratamiento del cáncer. La invención también proporciona un virus de la estomatitis vesicular recombinante que expresa un dominio antigénico y su uso en vacunas contra el cáncer.
MX2023002884A 2020-09-14 2021-09-14 Vacuna heterologa de estimulo primario. MX2023002884A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP20195872 2020-09-14
EP20210671 2020-11-30
EP21155814 2021-02-08
EP21176373 2021-05-27
PCT/EP2021/075184 WO2022053703A1 (en) 2020-09-14 2021-09-14 Heterologous prime boost vaccine

Publications (1)

Publication Number Publication Date
MX2023002884A true MX2023002884A (es) 2023-03-31

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ID=77897647

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002884A MX2023002884A (es) 2020-09-14 2021-09-14 Vacuna heterologa de estimulo primario.

Country Status (18)

Country Link
US (1) US20220088162A1 (es)
EP (1) EP4210734A1 (es)
JP (1) JP2023542297A (es)
KR (1) KR20230069956A (es)
CN (1) CN116348137A (es)
AU (1) AU2021341521A1 (es)
BR (1) BR112023001864A2 (es)
CA (1) CA3188236A1 (es)
CL (1) CL2023000642A1 (es)
CO (1) CO2023004596A2 (es)
CR (1) CR20230155A (es)
DO (1) DOP2023000053A (es)
EC (1) ECSP23027542A (es)
IL (1) IL300060A (es)
MX (1) MX2023002884A (es)
PE (1) PE20240492A1 (es)
TW (1) TW202227126A (es)
WO (1) WO2022053703A1 (es)

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1768698A4 (en) 2004-06-17 2009-01-28 Medimmune Inc IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES
DE102004034461B4 (de) 2004-07-16 2008-02-07 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Gentherapie solider Tumore durch retrovirale, mit Arenavirus-Glykoprotein pseudotypisierte Vektoren
ES2427646T5 (es) 2005-05-09 2017-08-22 Ono Pharmaceutical Co., Ltd. Anticuerpos monoclonales humanos contra muerte programada 1 (PD1) y métodos para el tratamiento del cáncer mediante el uso de anticuerpos anti-PD-1 solos o combinados con otros agentes inmunoterapéuticos
ES2291071B1 (es) 2005-06-13 2009-03-16 Proyecto De Biomedicina Cima, S.L. Agentes y metodos basados en el uso del dominio eda de la fibronectina.
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
RS53072B (en) 2007-06-18 2014-04-30 Merck Sharp & Dohme B.V. HUMAN RECEPTOR ANTIBODIES PROGRAMMED DEATH PD-1
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
PT2242773T (pt) 2008-02-11 2017-09-15 Cure Tech Ltd Anticorpos monoclonais para o tratamento de tumores
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
DE09780481T1 (de) 2008-07-11 2012-01-26 Medizinische Universität Innsbruck Agonisten von nr2f6 zur immunsuppression
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
DE102008050860A1 (de) 2008-10-08 2010-04-15 Dorothee Von Laer LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virenproduzentenzellen zur Therapie von Tumoren
HUE034832T2 (hu) 2008-12-09 2021-12-28 Hoffmann La Roche Anti-PD-L1 antitestek és alkalmazásuk T-sejt-funkció fokozására
JP5964233B2 (ja) 2009-09-11 2016-08-03 プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダＰｒｏｙｅｃｔｏ Ｄｅ Ｂｉｏｍｅｄｉｃｉｎａ Ｃｉｍａ， Ｓ．Ｌ． Ｈｐｖにより惹起される疾患の治療用組成物
ES2646863T3 (es) 2009-11-24 2017-12-18 Medimmune Limited Agentes de unión específica contra B7-H1
WO2011101332A1 (en) 2010-02-16 2011-08-25 Proyecto De Biomedicina Cima, S.L. Compositions based on the fibronectin extracellular domain a for the treatment of melanoma
WO2012015979A2 (en) 2010-07-27 2012-02-02 The Regents Of The University Of California Hmgb1-derived peptides enhance immune response to antigens
US9555074B2 (en) 2010-10-08 2017-01-31 Regents Of The University Of Minnesota Annexin II compositions
JP6138813B2 (ja) 2011-11-28 2017-05-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 抗ｐｄ−ｌ１抗体及びその使用
CN104244968B (zh) 2011-12-30 2017-07-25 哈洛齐梅公司 Ph20多肽变体、配制物及其应用
US9597393B2 (en) 2012-02-09 2017-03-21 Av Therapeutics, Inc. Synthetic toll-like receptor-4 (TLR-4) agonist peptides
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
EP4378957A2 (en) 2015-07-29 2024-06-05 Novartis AG Combination therapies comprising antibody molecules to pd-1

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CO2023004596A2 (es) 2023-07-10
CA3188236A1 (en) 2022-03-17
CL2023000642A1 (es) 2023-10-30
WO2022053703A1 (en) 2022-03-17
TW202227126A (zh) 2022-07-16
CN116348137A (zh) 2023-06-27
US20220088162A1 (en) 2022-03-24
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