JP6144355B2 - 化学修飾ｍＲＮＡ - Google Patents

化学修飾ｍＲＮＡ Download PDF

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Publication number
JP6144355B2
JP6144355B2 JP2015544065A JP2015544065A JP6144355B2 JP 6144355 B2 JP6144355 B2 JP 6144355B2 JP 2015544065 A JP2015544065 A JP 2015544065A JP 2015544065 A JP2015544065 A JP 2015544065A JP 6144355 B2 JP6144355 B2 JP 6144355B2
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mir
mrna
modified
utr
sequence
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Japanese (ja)
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JP2015535430A (ja
Inventor
チャクラボルティ、ティルタ
バンセル、ステファヌ
ジー． ホーグ、スティーブン
ジー． ホーグ、スティーブン
ロイ、アタヌ
フジェローレ、アントニン ドゥ
フジェローレ、アントニン ドゥ
ビー． アフェヤン、ヌバール
ビー． アフェヤン、ヌバール
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ModernaTx Inc
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ModernaTx Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
JP2015544065A 2012-11-26 2013-10-02 化学修飾ｍＲＮＡ Active JP6144355B2 (ja)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201261729933P 2012-11-26 2012-11-26
US61/729,933 2012-11-26
US201261737224P 2012-12-14 2012-12-14
US61/737,224 2012-12-14
US201361758921P 2013-01-31 2013-01-31
US61/758,921 2013-01-31
US201361775509P 2013-03-09 2013-03-09
US61/775,509 2013-03-09
US201361781139P 2013-03-14 2013-03-14
US61/781,139 2013-03-14
US201361829372P 2013-05-31 2013-05-31
US201361829359P 2013-05-31 2013-05-31
US61/829,372 2013-05-31
US61/829,359 2013-05-31
US201361839903P 2013-06-27 2013-06-27
US61/839,903 2013-06-27
US201361842709P 2013-07-03 2013-07-03
US61/842,709 2013-07-03
US201361857436P 2013-07-23 2013-07-23
US61/857,436 2013-07-23
PCT/US2013/062943 WO2014081507A1 (en) 2012-11-26 2013-10-02 Terminally modified rna

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017093692A Division JP6377804B2 (ja) 2012-11-26 2017-05-10 末端修飾ｒｎａ

Publications (2)

Publication Number Publication Date
JP2015535430A JP2015535430A (ja) 2015-12-14
JP6144355B2 true JP6144355B2 (ja) 2017-06-07

Family

ID=49447811

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2015544065A Active JP6144355B2 (ja) 2012-11-26 2013-10-02 化学修飾ｍＲＮＡ
JP2017093692A Expired - Fee Related JP6377804B2 (ja) 2012-11-26 2017-05-10 末端修飾ｒｎａ
JP2018138949A Active JP6666391B2 (ja) 2012-11-26 2018-07-25 化学修飾ｍＲＮＡ
JP2020026728A Active JP7047002B2 (ja) 2012-11-26 2020-02-20 化学修飾ｍＲＮＡ
JP2022046812A Pending JP2022093332A (ja) 2012-11-26 2022-03-23 化学修飾ｍＲＮＡ

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2017093692A Expired - Fee Related JP6377804B2 (ja) 2012-11-26 2017-05-10 末端修飾ｒｎａ
JP2018138949A Active JP6666391B2 (ja) 2012-11-26 2018-07-25 化学修飾ｍＲＮＡ
JP2020026728A Active JP7047002B2 (ja) 2012-11-26 2020-02-20 化学修飾ｍＲＮＡ
JP2022046812A Pending JP2022093332A (ja) 2012-11-26 2022-03-23 化学修飾ｍＲＮＡ

Country Status (16)

Country Link
US (5) US9597380B2 (https=)
EP (2) EP2922554B1 (https=)
JP (5) JP6144355B2 (https=)
AU (3) AU2017202228B2 (https=)
CA (1) CA2892529C (https=)
CY (1) CY1125236T1 (https=)
DK (1) DK2922554T3 (https=)
ES (1) ES2921623T3 (https=)
HR (1) HRP20220607T1 (https=)
LT (1) LT2922554T (https=)
PL (1) PL2922554T3 (https=)
PT (1) PT2922554T (https=)
RS (1) RS63237B1 (https=)
SI (1) SI2922554T1 (https=)
SM (1) SMT202200337T1 (https=)
WO (1) WO2014081507A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3312494B2 (ja) 1994-08-31 2002-08-05 富士ゼロックス株式会社 データ処理装置

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