|
US1073811A
(en)
|
1913-04-24 |
1913-09-23 |
Carl G Miller |
Fly-trap.
|
|
JPS5144499B1
(cg-RX-API-DMAC10.html)
|
1970-08-29 |
1976-11-29 |
|
|
|
JPS5334319B2
(cg-RX-API-DMAC10.html)
|
1971-12-28 |
1978-09-20 |
|
|
|
JPS5717624B2
(cg-RX-API-DMAC10.html)
|
1974-04-17 |
1982-04-12 |
|
|
|
US4208479A
(en)
|
1977-07-14 |
1980-06-17 |
Syva Company |
Label modified immunoassays
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
|
DE3377363D1
(en)
|
1982-03-31 |
1988-08-18 |
Ajinomoto Kk |
Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
|
|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
JPH0234615Y2
(cg-RX-API-DMAC10.html)
|
1986-08-08 |
1990-09-18 |
|
|
|
JPH06104071B2
(ja)
|
1986-08-24 |
1994-12-21 |
財団法人化学及血清療法研究所 |
第▲ix▼因子コンホメ−シヨン特異性モノクロ−ナル抗体
|
|
US5260203A
(en)
*
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
JPS63149900A
(ja)
|
1986-12-15 |
1988-06-22 |
Toshiba Corp |
半導体メモリ
|
|
US4851341A
(en)
|
1986-12-19 |
1989-07-25 |
Immunex Corporation |
Immunoaffinity purification system
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
JPH01144991A
(ja)
|
1987-12-02 |
1989-06-07 |
Kagaku Oyobi Ketsusei Riyouhou Kenkyusho |
血液凝固第8因子の精製方法
|
|
US5670373A
(en)
*
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
|
US5322678A
(en)
*
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
|
JPH0250497A
(ja)
|
1988-08-12 |
1990-02-20 |
Tokin Corp |
電波吸収体とその製造方法
|
|
IL91778A
(en)
|
1988-09-28 |
1994-10-07 |
Lilly Co Eli |
A method for reducing the heterogeneity of monoclonal antibodies
|
|
US5126250A
(en)
*
|
1988-09-28 |
1992-06-30 |
Eli Lilly And Company |
Method for the reduction of heterogeneity of monoclonal antibodies
|
|
IL89491A0
(en)
|
1988-11-17 |
1989-09-10 |
Hybritech Inc |
Bifunctional chimeric antibodies
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
GB8916400D0
(en)
|
1989-07-18 |
1989-09-06 |
Dynal As |
Modified igg3
|
|
JPH0636741B2
(ja)
|
1989-11-08 |
1994-05-18 |
帝人株式会社 |
ヒト・プロテインcの分離方法
|
|
EP0505357B1
(en)
|
1989-12-11 |
1999-03-10 |
Immunomedics, Inc. |
Method for antibody targeting of diagnostic or therapeutic agents
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
WO1996033735A1
(en)
|
1995-04-27 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5130129A
(en)
|
1990-03-06 |
1992-07-14 |
The Regents Of The University Of California |
Method for enhancing antibody transport through capillary barriers
|
|
TW212184B
(cg-RX-API-DMAC10.html)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
|
JPH05184383A
(ja)
|
1990-06-19 |
1993-07-27 |
Dainabotsuto Kk |
二重特異性抗体
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
AU665190B2
(en)
|
1990-07-10 |
1995-12-21 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
JPH05199894A
(ja)
|
1990-08-20 |
1993-08-10 |
Takeda Chem Ind Ltd |
二重特異性抗体および抗体含有薬剤
|
|
DK0814159T3
(da)
|
1990-08-29 |
2005-10-24 |
Genpharm Int |
Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
|
|
GB9022547D0
(en)
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Purified immunoglobulin
|
|
US5795965A
(en)
|
1991-04-25 |
1998-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human to human interleukin-6 receptor
|
|
JPH05304992A
(ja)
|
1991-06-20 |
1993-11-19 |
Takeda Chem Ind Ltd |
ハイブリッド・モノクローナル抗体および抗体含有薬剤
|
|
US5468634A
(en)
*
|
1991-06-24 |
1995-11-21 |
The University Of North Carolina At Chapel Hill |
Axl oncogene
|
|
US6136310A
(en)
|
1991-07-25 |
2000-10-24 |
Idec Pharmaceuticals Corporation |
Recombinant anti-CD4 antibodies for human therapy
|
|
ATE181571T1
(de)
|
1991-09-23 |
1999-07-15 |
Medical Res Council |
Methoden zur herstellung humanisierter antikörper
|
|
WO1993011161A1
(en)
|
1991-11-25 |
1993-06-10 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
US5885793A
(en)
|
1991-12-02 |
1999-03-23 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
|
EP0746609A4
(en)
|
1991-12-17 |
1997-12-17 |
Genpharm Int |
NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
JPH05203652A
(ja)
|
1992-01-28 |
1993-08-10 |
Fuji Photo Film Co Ltd |
抗体酵素免疫分析法
|
|
JPH05213775A
(ja)
|
1992-02-05 |
1993-08-24 |
Otsuka Pharmaceut Co Ltd |
Bfa抗体
|
|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
|
JP3507073B2
(ja)
|
1992-03-24 |
2004-03-15 |
ケンブリッジ アンティボディー テクノロジー リミティド |
特異的結合対の成員の製造方法
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
US5744446A
(en)
|
1992-04-07 |
1998-04-28 |
Emory University |
Hybrid human/animal factor VIII
|
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
ATE381614T1
(de)
|
1992-07-24 |
2008-01-15 |
Amgen Fremont Inc |
Bildung von xenogenen antikörpern
|
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
BR9204244A
(pt)
|
1992-10-26 |
1994-05-03 |
Cofap |
Ferro fundido cinzento
|
|
FI952658A0
(fi)
|
1992-12-01 |
1995-05-31 |
Protein Design Labs Inc |
L-selektiinin kanssa reaktiivisia humanisoituja vasta-aineita
|
|
AU690528B2
(en)
|
1992-12-04 |
1998-04-30 |
Medical Research Council |
Multivalent and multispecific binding proteins, their manufacture and use
|
|
US7393682B1
(en)
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
|
JPH09507829A
(ja)
|
1993-03-19 |
1997-08-12 |
ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン |
増殖分化因子−8
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
AU7214294A
(en)
|
1993-07-01 |
1995-01-24 |
Dade International Inc. |
Process for the preparation of factor x depleted plasma
|
|
GB9314271D0
(en)
|
1993-07-09 |
1993-08-18 |
Inst Of Cancer The Research |
Cell growth factor receptors
|
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
|
AU7967294A
(en)
|
1993-10-06 |
1995-05-01 |
Board Of Regents, The University Of Texas System |
A monoclonal anti-human il-6 receptor antibody
|
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
|
US6214613B1
(en)
|
1993-12-03 |
2001-04-10 |
Ashai Kasei Kogyo Kabushiki Kaisha |
Expression screening vector
|
|
EP0731842A1
(en)
|
1993-12-03 |
1996-09-18 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
|
US5945311A
(en)
*
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
|
DE4419399C1
(de)
|
1994-06-03 |
1995-03-09 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
|
US8017121B2
(en)
*
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
WO1996001653A1
(en)
|
1994-07-11 |
1996-01-25 |
Board Of Regents, The University Of Texas System |
Methods and compositions for the specific coagulation of vasculature
|
|
TW416960B
(en)
|
1994-07-13 |
2001-01-01 |
Chugai Pharmaceutical Co Ltd |
Reshaped human antibody to human interleukin-8
|
|
HU221385B1
(en)
|
1994-07-13 |
2002-09-28 |
Chugai Pharmaceutical Co Ltd |
Reconstituted human antibody against human interleukin-8
|
|
US6048972A
(en)
|
1994-07-13 |
2000-04-11 |
Chugai Pharmaceutical Co., Ltd. |
Recombinant materials for producing humanized anti-IL-8 antibodies
|
|
JP3865418B2
(ja)
|
1994-07-13 |
2007-01-10 |
中外製薬株式会社 |
ヒトインターロイキン−8に対する再構成ヒト抗体
|
|
CN1156460A
(zh)
|
1994-07-13 |
1997-08-06 |
中外制药株式会社 |
抗人白细胞介素-8的重构人抗体
|
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
|
CN101601861A
(zh)
|
1994-10-07 |
2009-12-16 |
中外制药株式会社 |
以il-6拮抗剂作为有效成分治疗慢性类风湿性关节炎
|
|
EP2319535A3
(en)
|
1994-10-21 |
2011-08-31 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition for treatment of diseases caused by IL-6 production
|
|
JPH10511085A
(ja)
|
1994-12-02 |
1998-10-27 |
カイロン コーポレイション |
二重特異性抗体を用いる免疫応答を促進する方法
|
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
|
US5876950A
(en)
|
1995-01-26 |
1999-03-02 |
Bristol-Myers Squibb Company |
Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
|
|
CA2210309C
(en)
|
1995-02-28 |
2002-04-16 |
The Procter & Gamble Company |
Preparation of noncarbonated beverage products having superior microbial stability
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
CA2205007C
(en)
|
1995-09-11 |
2010-12-14 |
Masamichi Koike |
Antibody against human interleukin-5 receptor .alpha. chain
|
|
MA24512A1
(fr)
|
1996-01-17 |
1998-12-31 |
Univ Vermont And State Agrienl |
Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
JP3032287U
(ja)
|
1996-06-10 |
1996-12-17 |
幸喜 高橋 |
人 形
|
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
|
ZA976326B
(en)
*
|
1996-07-19 |
1998-02-03 |
Amgen Inc |
Analogs of cationic proteins.
|
|
US7247302B1
(en)
|
1996-08-02 |
2007-07-24 |
Bristol-Myers Squibb Company |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
WO1998005787A1
(en)
|
1996-08-02 |
1998-02-12 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
WO1998013388A1
(en)
|
1996-09-26 |
1998-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody against human parathormone related peptides
|
|
JPH10165184A
(ja)
|
1996-12-16 |
1998-06-23 |
Tosoh Corp |
抗体、遺伝子及びキメラ抗体の製法
|
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
|
US6025158A
(en)
|
1997-02-21 |
2000-02-15 |
Genentech, Inc. |
Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
AU736282B2
(en)
|
1997-03-21 |
2001-07-26 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
|
|
US6884879B1
(en)
*
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US20070059302A1
(en)
*
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
FR2761994B1
(fr)
|
1997-04-11 |
1999-06-18 |
Centre Nat Rech Scient |
Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
|
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
JP4213224B2
(ja)
|
1997-05-02 |
2009-01-21 |
ジェネンテック,インコーポレーテッド |
ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
|
|
DE19725586C2
(de)
|
1997-06-17 |
1999-06-24 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper
|
|
CN1068524C
(zh)
|
1997-06-23 |
2001-07-18 |
叶庆炜 |
一种治疗顽症牛皮癣的药物
|
|
US5980893A
(en)
|
1997-07-17 |
1999-11-09 |
Beth Israel Deaconess Medical Center, Inc. |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
|
|
US6207805B1
(en)
|
1997-07-18 |
2001-03-27 |
University Of Iowa Research Foundation |
Prostate cell surface antigen-specific antibodies
|
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
PT1004315E
(pt)
|
1997-08-15 |
2008-07-09 |
Chugai Pharmaceutical Co Ltd |
Profilácticos e/ou medicamentos contendo anticorpos neutralizantes anti-receptor de il-6 para reduzir a excreção de proteínas urinárias no lúpus eritematoso sistémico
|
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
|
IL135221A0
(en)
*
|
1997-10-03 |
2001-05-20 |
Chugai Pharmaceutical Co Ltd |
Natural humanized antibody and methods for the preparation thereof
|
|
US6458355B1
(en)
|
1998-01-22 |
2002-10-01 |
Genentech, Inc. |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
|
|
ES2299241T3
(es)
|
1998-03-17 |
2008-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6.
|
|
JP2002510481A
(ja)
|
1998-04-02 |
2002-04-09 |
ジェネンテック・インコーポレーテッド |
抗体変異体及びその断片
|
|
KR20010042435A
(ko)
|
1998-04-03 |
2001-05-25 |
나가야마 오사무 |
인간조직인자(티에프)에 대한 인간형화항체 및인간형화항체의 제조방법
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
WO2000009560A2
(en)
*
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
CN1214043C
(zh)
*
|
1998-12-01 |
2005-08-10 |
蛋白质设计实验室股份有限公司 |
抗γ-干扰素的人化抗体
|
|
CA2342967A1
(en)
|
1998-12-08 |
2000-06-15 |
Biovation Limited |
Modifying protein immunogenicity
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
ES2694002T3
(es)
|
1999-01-15 |
2018-12-17 |
Genentech, Inc. |
Polipéptido que comprende una región Fc de IgG1 humana variante
|
|
US6972125B2
(en)
*
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
|
AU2006225302B2
(en)
|
1999-03-25 |
2010-08-12 |
AbbVie Deutschland GmbH & Co. KG |
Human antibodies that bind human IL-12 and methods for producing
|
|
EP2135953B1
(en)
|
1999-06-02 |
2014-04-23 |
Chugai Seiyaku Kabushiki Kaisha |
Novel hemopoietin receptor protein, Nr. 10
|
|
SK782002A3
(en)
*
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
AT411997B
(de)
|
1999-09-14 |
2004-08-26 |
Baxter Ag |
Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
|
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
|
AU2001249835A1
(en)
*
|
2000-04-03 |
2001-10-15 |
Oxford Glycosciences (Uk) Ltd. |
Diagnosis and treatment of alzheimer's disease
|
|
AU5391401A
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences Inc |
Targeted modification of chromatin structure
|
|
CZ20023913A3
(cs)
|
2000-05-03 |
2003-09-17 |
Munich Biotech Ag |
Kationtová diagnostická, zobrazovací a terapeutická činidla spojená s aktivovanými cévními místy
|
|
EP1299419A2
(en)
|
2000-05-24 |
2003-04-09 |
Imclone Systems, Inc. |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
AU2001271066A1
(en)
|
2000-07-17 |
2002-01-30 |
Chugai Seiyaku Kabushiki Kaisha |
Method for screening ligand having biological activity
|
|
AU2011244851A1
(en)
|
2000-07-27 |
2011-11-24 |
The John Hopkins University School Of Medicine |
Promyostatin peptides and methods of using same
|
|
ATE449791T1
(de)
|
2000-10-10 |
2009-12-15 |
Genentech Inc |
Inhibierung von c5 komplement-aktivierung für die behandlung und vorbeugung von xeno-transplantat oder akute vaskuläre abstossung
|
|
WO2002030463A2
(en)
|
2000-10-12 |
2002-04-18 |
Genentech, Inc. |
Reduced-viscosity concentrated protein formulations
|
|
EP1327681A4
(en)
|
2000-10-20 |
2004-09-01 |
Chugai Pharmaceutical Co Ltd |
Degraded agonist antibodies
|
|
ATE387215T1
(de)
|
2000-10-25 |
2008-03-15 |
Chugai Pharmaceutical Co Ltd |
Mittel zur prävention oder behandlung von psoriasis mit einem il-6-antagonist als wirkstoff
|
|
AU2000279625A1
(en)
*
|
2000-10-27 |
2002-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
|
|
ES2727425T3
(es)
|
2000-12-12 |
2019-10-16 |
Medimmune Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
|
RU2179862C1
(ru)
|
2000-12-26 |
2002-02-27 |
Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" |
Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
|
|
EP1366067B1
(en)
|
2001-03-07 |
2012-09-26 |
Merck Patent GmbH |
Expression technology for proteins containing a hybrid isotype antibody moiety
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
YU80903A
(sh)
*
|
2001-04-13 |
2006-05-25 |
Biogen Inc. |
Antitela vla-1
|
|
KR100953520B1
(ko)
|
2001-06-22 |
2010-04-21 |
츄가이 세이야꾸 가부시키가이샤 |
항글리피칸 3항체를 포함하는 항암제
|
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
|
MXPA04001301A
(es)
|
2001-08-17 |
2004-07-08 |
Tanox Inc |
Inhibidores de la ruta del complemento que se unen a c5 y c5a son evitar la formacion de c5b.
|
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
ATE430580T1
(de)
|
2001-10-25 |
2009-05-15 |
Genentech Inc |
Glycoprotein-zusammensetzungen
|
|
US20030190705A1
(en)
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
|
PT1562968E
(pt)
|
2001-11-14 |
2013-10-23 |
Janssen Biotech Inc |
Anticorpos anti-il-6, composições, métodos e utilizações
|
|
EP1461423B1
(en)
|
2001-12-03 |
2008-05-14 |
Amgen Fremont Inc. |
Antibody categorization based on binding characteristics
|
|
AU2002362197A1
(en)
|
2001-12-28 |
2003-07-24 |
Chugai Seiyaku Kabushiki Kaisha |
Method of stabilizing protein
|
|
DE60333963D1
(de)
|
2002-01-18 |
2010-10-07 |
Zymogenetics Inc |
Zytokin Ligand zur Behandlung von Asthma und Atemwegsüberreaktivität
|
|
ATE547430T1
(de)
*
|
2002-01-18 |
2012-03-15 |
Zymogenetics Inc |
Multimere des cytokinrezeptors zcytor17
|
|
KR20040082421A
(ko)
*
|
2002-02-11 |
2004-09-24 |
제넨테크, 인크. |
빠른 항원 결합 속도를 갖는 항체 변이체
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US8188231B2
(en)
*
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
US8093357B2
(en)
|
2002-03-01 |
2012-01-10 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20030216551A1
(en)
|
2002-03-08 |
2003-11-20 |
Diabetogen Biosciences Inc. |
Fully human anti-CD3 monoclonal antibodies
|
|
US7736652B2
(en)
|
2002-03-21 |
2010-06-15 |
The Regents Of The University Of California |
Antibody fusion proteins: effective adjuvants of protein vaccination
|
|
AU2003227504A1
(en)
|
2002-04-15 |
2003-10-27 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD OF CONSTRUCTING scDb LIBRARY
|
|
AU2003222664A1
(en)
|
2002-04-18 |
2003-11-03 |
Genencor International, Inc. |
Production of functional antibodies in filamentous fungi
|
|
AU2003235833A1
(en)
|
2002-04-26 |
2003-11-10 |
Chugai Seiyaku Kabushiki Kaisha |
Method of screening agonistic antibody
|
|
WO2003107218A1
(ja)
|
2002-05-31 |
2003-12-24 |
セレスター・レキシコ・サイエンシズ株式会社 |
相互作用予測装置
|
|
JP2004086862A
(ja)
|
2002-05-31 |
2004-03-18 |
Celestar Lexico-Sciences Inc |
タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
|
|
WO2003102580A1
(en)
|
2002-05-31 |
2003-12-11 |
Biacore Ab |
Method of coupling binding agents to a substrate surface
|
|
EP1511861A4
(en)
|
2002-06-12 |
2007-12-05 |
Genencor Int |
METHODS AND BINDING COMPOSITIONS DEPENDENT FROM THE MEDIUM OF A TARGET AGENT TO A TARGET
|
|
ATE426815T1
(de)
|
2002-06-12 |
2009-04-15 |
Genencor Int |
Verfahren zur verbesserung einer bindungseigenschaft eines molekuls
|
|
ITMI20021527A1
(it)
|
2002-07-11 |
2004-01-12 |
Consiglio Nazionale Ricerche |
Anticorpi anti componente c5 del complemento e loro uso
|
|
EP1382969A1
(en)
|
2002-07-17 |
2004-01-21 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Diagnosis and prevention of cancer cell invasion
|
|
CN100480260C
(zh)
|
2002-07-18 |
2009-04-22 |
克鲁塞尔荷兰公司 |
抗体混合物的重组生产
|
|
TW200407335A
(en)
*
|
2002-07-22 |
2004-05-16 |
Chugai Pharmaceutical Co Ltd |
Non-neutralizing antibody to inhibit the inactivation of activated protein C
|
|
CA2492524A1
(en)
|
2002-08-15 |
2004-02-26 |
Epitomics, Inc. |
Humanized rabbit antibodies
|
|
JP4463104B2
(ja)
|
2002-08-30 |
2010-05-12 |
財団法人化学及血清療法研究所 |
ヒト抗ヒトインターロイキン−6抗体及び該抗体フラグメント
|
|
MXPA05002648A
(es)
|
2002-09-16 |
2005-08-19 |
Wyeth Corp |
Activacion de miostatina por metaloproteasa, y metodos para modular la actividad de miostatina.
|
|
ES2562177T3
(es)
|
2002-09-27 |
2016-03-02 |
Xencor Inc. |
Variantes de Fc optimizadas y métodos para su generación
|
|
EP1562972B1
(en)
|
2002-10-15 |
2010-09-08 |
Facet Biotech Corporation |
ALTERATION OF FcRn BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
GB0224082D0
(en)
|
2002-10-16 |
2002-11-27 |
Celltech R&D Ltd |
Biological products
|
|
US7261893B2
(en)
|
2002-10-22 |
2007-08-28 |
Wyeth |
Neutralizing antibodies against GDF-8 and uses therefor
|
|
NZ541050A
(en)
|
2002-12-16 |
2010-06-25 |
Genmab As |
Human monoclonal antibodies against interleukin 8 (IL-8)
|
|
KR101410692B1
(ko)
|
2002-12-24 |
2014-06-24 |
리나트 뉴로사이언스 코프. |
항-ngf 항체 및 그것을 이용하는 방법
|
|
AU2003303543A1
(en)
|
2002-12-26 |
2004-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
Agonist antibody against heteroreceptor
|
|
EP1605058B1
(en)
|
2003-01-21 |
2009-05-13 |
Chugai Seiyaku Kabushiki Kaisha |
Method of screening light chain of antibody light chains
|
|
CA2515081A1
(en)
|
2003-02-07 |
2004-08-19 |
Protein Design Labs, Inc. |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
|
US20040223970A1
(en)
*
|
2003-02-28 |
2004-11-11 |
Daniel Afar |
Antibodies against SLC15A2 and uses thereof
|
|
CA2517396A1
(en)
|
2003-02-28 |
2005-03-10 |
Antigenics Inc. |
Use of lectins to promote oligomerization of glycoproteins and antigenic molecules
|
|
JP4607010B2
(ja)
|
2003-02-28 |
2011-01-05 |
中外製薬株式会社 |
タンパク質含有安定化製剤
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
ES2527414T3
(es)
|
2003-03-04 |
2015-01-23 |
Alexion Pharmaceuticals, Inc. |
Método para el tratamiento de una enfermedad autoinmune mediante la inducción de la presentación de antígeno mediante células presentadoras de antígeno que inducen tolerancia
|
|
GB0306098D0
(en)
*
|
2003-03-18 |
2003-04-23 |
Platform Diagnostics Group Ltd |
Sample testing device
|
|
CN103864934A
(zh)
|
2003-03-24 |
2014-06-18 |
津莫吉尼蒂克斯公司 |
抗il-22ra抗体和结合伴侣以及在炎症中的使用方法
|
|
GB2400851B
(en)
|
2003-04-25 |
2004-12-15 |
Bioinvent Int Ab |
Identifying binding of a polypeptide to a polypeptide target
|
|
JP2004321100A
(ja)
|
2003-04-25 |
2004-11-18 |
Rikogaku Shinkokai |
IgGのFc領域を含むタンパク質の変異体
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
US9051373B2
(en)
|
2003-05-02 |
2015-06-09 |
Xencor, Inc. |
Optimized Fc variants
|
|
WO2005000900A1
(en)
|
2003-05-30 |
2005-01-06 |
Genentech, Inc. |
Treatment with anti-vegf antibodies
|
|
CA2527694C
(en)
*
|
2003-05-30 |
2015-07-14 |
Hendricus Renerus Jacobus Mattheus Hoogenboom |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
KR20060026860A
(ko)
|
2003-06-02 |
2006-03-24 |
와이어쓰 |
신경근 장애의 치료를 위한, 코르티코스테로이드와 조합된미오스타틴 (gdf8) 저해제의 용도
|
|
EP1629001A2
(en)
|
2003-06-05 |
2006-03-01 |
Genentech, Inc. |
Blys antagonists and uses thereof
|
|
US8597911B2
(en)
|
2003-06-11 |
2013-12-03 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibodies
|
|
WO2004113387A2
(en)
|
2003-06-24 |
2004-12-29 |
Merck Patent Gmbh |
Tumour necrosis factor receptor molecules with reduced immunogenicity
|
|
WO2005005604A2
(en)
|
2003-06-30 |
2005-01-20 |
Centocor, Inc. |
Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
|
|
WO2005023193A2
(en)
|
2003-09-04 |
2005-03-17 |
Interleukin Genetics, Inc. |
Methods of treating endometriosis
|
|
US7297336B2
(en)
|
2003-09-12 |
2007-11-20 |
Baxter International Inc. |
Factor IXa specific antibodies displaying factor VIIIa like activity
|
|
JP2005101105A
(ja)
|
2003-09-22 |
2005-04-14 |
Canon Inc |
位置決め装置、露光装置、デバイス製造方法
|
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
|
JP2005112514A
(ja)
|
2003-10-06 |
2005-04-28 |
Tadano Ltd |
伸縮ブーム
|
|
AU2003271174A1
(en)
*
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
|
US20080075712A1
(en)
*
|
2003-10-14 |
2008-03-27 |
Kunihiro Hattori |
Double Specific Antibodies Substituting For Functional Proteins
|
|
JP2007531707A
(ja)
|
2003-10-15 |
2007-11-08 |
ピーディーエル バイオファーマ, インコーポレイテッド |
IGの重鎖定常領域の位置250、314および/または428の変異誘発によるFc融合タンパク質血清半減期の改変
|
|
JP4651541B2
(ja)
|
2003-10-17 |
2011-03-16 |
中外製薬株式会社 |
中皮腫治療剤
|
|
CA2545603A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
|
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
|
EP1701979A2
(en)
|
2003-12-03 |
2006-09-20 |
Xencor, Inc. |
Optimized antibodies that target the epidermal growth factor receptor
|
|
WO2005056759A2
(en)
|
2003-12-04 |
2005-06-23 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
|
HUE025328T2
(en)
*
|
2003-12-10 |
2016-03-29 |
Squibb & Sons Llc |
IP-10 antibodies and their use
|
|
US7741449B2
(en)
|
2003-12-10 |
2010-06-22 |
Medarex, Inc. |
Anti-interferon alpha antibodies
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
EP1697748A4
(en)
|
2003-12-22 |
2007-07-04 |
Centocor Inc |
METHODS FOR GENERATING MULTIMEDIA MOLECULES
|
|
WO2005077981A2
(en)
|
2003-12-22 |
2005-08-25 |
Xencor, Inc. |
Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
|
|
EP1707627B1
(en)
|
2003-12-25 |
2012-11-14 |
Kyowa Hakko Kirin Co., Ltd. |
Antagonistic anti-CD40 antibody mutant
|
|
EP1699822B1
(en)
|
2003-12-30 |
2008-04-23 |
MERCK PATENT GmbH |
Il-7 fusion proteins with antibody portions, their preparation and their use
|
|
BRPI0418317A
(pt)
|
2003-12-31 |
2007-05-02 |
Schering Plough Ltd |
vacina de aumento de crescimento à base de epitopo de neutralização
|
|
US20050266425A1
(en)
*
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
|
ITMI20040003A1
(it)
|
2004-01-07 |
2004-04-07 |
Zambon Spa |
Processo per la preparazione di 6-fluoro-2-metil-1-indanone
|
|
ES2362667T3
(es)
|
2004-01-09 |
2011-07-11 |
Pfizer Inc. |
ANTICUERPOS FRENTE A MAdCAM.
|
|
BRPI0506771A
(pt)
|
2004-01-12 |
2007-05-22 |
Applied Molecular Evolution |
anticorpo, e, composição farmacêutica
|
|
US20050169921A1
(en)
|
2004-02-03 |
2005-08-04 |
Leonard Bell |
Method of treating hemolytic disease
|
|
US20070116710A1
(en)
|
2004-02-03 |
2007-05-24 |
Leonard Bell |
Methods of treating hemolytic anemia
|
|
DE602005020743D1
(de)
|
2004-02-11 |
2010-06-02 |
Warner Lambert Co |
Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern
|
|
ES2384176T3
(es)
|
2004-03-23 |
2012-07-02 |
Eli Lilly & Company |
Anticuerpos anti-miostatina
|
|
EP1737890A2
(en)
|
2004-03-24 |
2007-01-03 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
|
US8398980B2
(en)
|
2004-03-24 |
2013-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleuken-6 receptor
|
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
KR20070035482A
(ko)
|
2004-03-24 |
2007-03-30 |
추가이 세이야쿠 가부시키가이샤 |
인터로킨-6 안타고니스트를 활성성분으로 함유하는내이장해 치료제
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
|
WO2005115452A2
(en)
|
2004-04-16 |
2005-12-08 |
Macrogenics, Inc. |
Fcϝriib-specific antibodies and methods of use thereof
|
|
KR100620554B1
(ko)
*
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
AU2005259992A1
(en)
|
2004-06-25 |
2006-01-12 |
Medimmune, Llc |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
|
CA2572917C
(en)
|
2004-07-06 |
2012-04-03 |
Bioren Inc. |
Look-through mutagenesis for developing altered polypeptides with enhanced properties
|
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
|
CA2544692C
(en)
|
2004-07-09 |
2014-04-01 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-glypican 3 antibody
|
|
CN103172731A
(zh)
|
2004-07-15 |
2013-06-26 |
赞科股份有限公司 |
优化的Fc变体
|
|
DK2213683T3
(da)
|
2004-08-04 |
2013-09-02 |
Mentrik Biotech Llc |
VARIANT-Fc-REGIONER
|
|
US20060040325A1
(en)
|
2004-08-16 |
2006-02-23 |
Medimmune, Inc. |
Integrin antagonists with enhanced antibody dependent cell-mediated cytoxicity activity
|
|
CA2577133A1
(en)
|
2004-08-19 |
2006-03-23 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
JP2008511337A
(ja)
*
|
2004-09-02 |
2008-04-17 |
ジェネンテック・インコーポレーテッド |
ヘテロ多量体分子
|
|
CA2579142A1
(en)
|
2004-09-13 |
2006-03-23 |
Macrogenics, Inc. |
Humanized antibodies against west nile virus and therapeutic and prophylactic uses thereof
|
|
WO2006031994A2
(en)
|
2004-09-14 |
2006-03-23 |
Xencor, Inc. |
Monomeric immunoglobulin fc domains
|
|
US20080233131A1
(en)
|
2004-09-14 |
2008-09-25 |
Richard John Stebbings |
Vaccine
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ox40l抗體
|
|
WO2006033386A1
(ja)
|
2004-09-22 |
2006-03-30 |
Kirin Beer Kabushiki Kaisha |
安定化されたヒトIgG4抗体
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
WO2007084253A2
(en)
|
2005-11-28 |
2007-07-26 |
Medimmune, Inc. |
High affinity antibodies against hmgb1 and methods of use thereof
|
|
KR20070090890A
(ko)
|
2004-10-22 |
2007-09-06 |
메디뮨 인코포레이티드 |
Hmgb1에 대한 고 친화성 항체 및 이의 사용 방법
|
|
JP5553963B2
(ja)
*
|
2004-10-22 |
2014-07-23 |
アムジエン・インコーポレーテツド |
組換え抗体をリフォールディングする方法
|
|
WO2006050166A2
(en)
|
2004-10-29 |
2006-05-11 |
Medimmune, Inc. |
Methods of preventing and treating rsv infections and related conditions
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
US7632497B2
(en)
*
|
2004-11-10 |
2009-12-15 |
Macrogenics, Inc. |
Engineering Fc Antibody regions to confer effector function
|
|
CN101098890B
(zh)
|
2004-11-12 |
2012-07-18 |
赞科股份有限公司 |
对FcRn的结合被改变的Fc变体
|
|
EP2325206B1
(en)
|
2004-11-12 |
2014-03-19 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
CA2586803C
(en)
|
2004-12-14 |
2012-12-11 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
US8329186B2
(en)
|
2004-12-20 |
2012-12-11 |
Isu Abxis Co., Ltd |
Treatment of inflammation using BST2 inhibitor
|
|
US8728828B2
(en)
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
US20090061485A1
(en)
|
2004-12-22 |
2009-03-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
|
|
EP1833510A4
(en)
|
2004-12-27 |
2010-02-10 |
Progenics Pharmaceuticals Neva |
ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME
|
|
WO2006070286A2
(en)
|
2004-12-28 |
2006-07-06 |
Innate Pharma S.A. |
Monoclonal antibodies against nkg2a
|
|
WO2006076594A2
(en)
*
|
2005-01-12 |
2006-07-20 |
Xencor, Inc. |
Antibodies and fc fusion proteins with altered immunogenicity
|
|
WO2006075668A1
(ja)
|
2005-01-12 |
2006-07-20 |
Kirin Beer Kabushiki Kaisha |
安定化されたヒトIgG2およびIgG3抗体
|
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
|
AU2006214404B2
(en)
|
2005-02-14 |
2012-03-08 |
Bristol-Myers Squibb Company |
Methods of treating skin disorders using an IL-31RA antagonist
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
JP5153613B2
(ja)
|
2005-03-18 |
2013-02-27 |
メディミューン,エルエルシー |
抗体のフレームワーク・シャッフル
|
|
CA2602663A1
(en)
|
2005-03-31 |
2006-10-05 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
CN101198698B
(zh)
|
2005-03-31 |
2014-03-19 |
中外制药株式会社 |
通过调节多肽缔合制备多肽的方法
|
|
EP1870458B1
(en)
|
2005-03-31 |
2018-05-09 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2 STRUCTURAL ISOMERS
|
|
PT1876236E
(pt)
|
2005-04-08 |
2014-10-22 |
Chugai Pharmaceutical Co Ltd |
Anticorpos para substituição da função do factor de coagulação sanguínea viii
|
|
SG161281A1
(en)
|
2005-04-15 |
2010-05-27 |
Genentech Inc |
Hgf beta chain variants
|
|
JP4909988B2
(ja)
|
2005-04-20 |
2012-04-04 |
アムジエン・フレモント・インコーポレイテツド |
インターロイキン‐8に対する高親和性の完全ヒトモノクローナル抗体、およびそのような抗体のエピトープ
|
|
EA015534B1
(ru)
|
2005-04-25 |
2011-08-30 |
Пфайзер Инк. |
Антитела к миостатину и способы их применения
|
|
JP5255435B2
(ja)
|
2005-04-26 |
2013-08-07 |
メディミューン,エルエルシー |
ヒンジドメイン操作による抗体エフェクター機能の調節
|
|
PE20061324A1
(es)
|
2005-04-29 |
2007-01-15 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, metodos y usos
|
|
MY148086A
(en)
|
2005-04-29 |
2013-02-28 |
Rinat Neuroscience Corp |
Antibodies directed against amyloid-beta peptide and methods using same
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
JP5047947B2
(ja)
|
2005-05-05 |
2012-10-10 |
デューク ユニバーシティ |
自己免疫疾患のための抗cd19抗体治療
|
|
WO2007143231A2
(en)
*
|
2006-01-10 |
2007-12-13 |
Zymogenetics, Inc. |
Methods of treating pain and inflammation in neuronal tissue using il-31 antagonists
|
|
US8163881B2
(en)
|
2005-05-31 |
2012-04-24 |
The Board Of Regents Of The University Of Texas System |
Immunoglobulin molecules with improved characteristics
|
|
JP5068167B2
(ja)
*
|
2005-06-10 |
2012-11-07 |
中外製薬株式会社 |
メグルミンを含有するタンパク質製剤の安定化剤、およびその利用
|
|
EP1900814A4
(en)
|
2005-06-10 |
2010-07-21 |
Chugai Pharmaceutical Co Ltd |
SCREED SC (FV) 2-MUTANTE
|
|
JP2008546805A
(ja)
|
2005-06-23 |
2008-12-25 |
メディミューン,エルエルシー |
最適な凝集および断片化プロフィールを有する抗体製剤
|
|
WO2007008943A2
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc. |
Optimized anti-ep-cam antibodies
|
|
CA2614766A1
(en)
|
2005-07-11 |
2007-01-18 |
Macrogenics, Inc. |
Methods of treating autoimmune disease using humanized anti-cd16a antibodies
|
|
CA2618681C
(en)
|
2005-08-10 |
2015-10-27 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
|
ES2534760T3
(es)
|
2005-08-19 |
2015-04-28 |
Wyeth Llc |
Anticuerpos antagonistas contra GDF-8 y sus usos en el tratamiento de ELA y otros trastornos asociados con GDF-8
|
|
WO2007032634A1
(en)
|
2005-09-12 |
2007-03-22 |
Industry Foundation Of Chonnam National University |
A method for production of mature natural killer cell
|
|
AU2006297173A1
(en)
|
2005-09-29 |
2007-04-12 |
Viral Logic Systems Technology Corp. |
Immunomodulatory compositions and uses therefor
|
|
CA2624189A1
(en)
|
2005-10-03 |
2007-04-12 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
|
CN101277976B
(zh)
|
2005-10-06 |
2012-04-11 |
伊莱利利公司 |
抗肌抑制素抗体
|
|
JP4860703B2
(ja)
|
2005-10-06 |
2012-01-25 |
ゼンコー・インコーポレイテッド |
最適化された抗cd30抗体
|
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
|
WO2007043641A1
(ja)
|
2005-10-14 |
2007-04-19 |
Fukuoka University |
膵島移植における移植膵島障害抑制剤
|
|
RU2450830C2
(ru)
|
2005-10-21 |
2012-05-20 |
Чугаи Сейяку Кабусики Кайся |
Средства для лечения кардиопатии
|
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
KR20080084818A
(ko)
|
2005-11-25 |
2008-09-19 |
각고호우징 게이오기주크 |
전립선암 치료제
|
|
AU2006326283B2
(en)
|
2005-12-12 |
2012-01-19 |
Ac Immune S.A. |
Therapeutic vaccine
|
|
US9084777B2
(en)
|
2005-12-28 |
2015-07-21 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized antibody-containing formulations
|
|
NZ599035A
(en)
*
|
2006-01-12 |
2013-12-20 |
Alexion Pharma Inc |
Antibodies to ox-2/cd200 and uses thereof
|
|
EP3135298B1
(en)
|
2006-01-27 |
2018-06-06 |
Keio University |
Therapeutic agents for diseases involving choroidal neovascularization
|
|
KR20080098504A
(ko)
|
2006-02-03 |
2008-11-10 |
메디뮨 엘엘씨 |
단백질 제제
|
|
US20070190056A1
(en)
|
2006-02-07 |
2007-08-16 |
Ravi Kambadur |
Muscle regeneration compositions and uses therefor
|
|
JP4179517B2
(ja)
|
2006-02-21 |
2008-11-12 |
プロテノバ株式会社 |
イムノグロブリン親和性リガンド
|
|
US8674073B2
(en)
|
2006-02-21 |
2014-03-18 |
Protenova Co., Ltd. |
Immunoglobulin affinity ligand
|
|
PT1988882E
(pt)
|
2006-03-02 |
2015-02-17 |
Alexion Pharma Inc |
Prolongamento da sobrevivência de um aloenxerto por inibição da atividade do complemento
|
|
KR101513308B1
(ko)
|
2006-03-08 |
2015-04-28 |
아케믹스 엘엘씨 |
안질환의 치료에 유용한 보체 결합 앱타머 및 항-c5 제제
|
|
EP2359834B1
(en)
|
2006-03-15 |
2016-11-09 |
Alexion Pharmaceuticals, Inc. |
Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
|
|
BRPI0709598A8
(pt)
|
2006-03-17 |
2019-01-08 |
Biogen Idec Inc |
composições de polipeptídeos estabilizados
|
|
US8048421B2
(en)
*
|
2006-03-23 |
2011-11-01 |
Kyowa Hakko Kirin Co., Ltd. |
Agonist antibody to human thrombopoietin receptor
|
|
MY169492A
(en)
|
2006-03-23 |
2019-04-15 |
Bioarctic Neuroscience Ab |
Improved protofibril selective antibodies and the use thereof
|
|
MX2008012146A
(es)
|
2006-03-28 |
2008-10-03 |
Biogen Idec Inc |
Anticuerpos anti-receptor 1 de factor de crecimiento tipo insulina (igf-1r) y uso de los mismos.
|
|
DK2009101T3
(en)
|
2006-03-31 |
2018-01-15 |
Chugai Pharmaceutical Co Ltd |
Antibody modification method for purification of a bispecific antibody
|
|
IN2014DN10515A
(cg-RX-API-DMAC10.html)
|
2006-03-31 |
2015-08-21 |
Chugai Pharmaceutical Co Ltd |
|
|
CA2648644C
(en)
|
2006-04-07 |
2016-01-05 |
Osaka University |
Muscle regeneration promoter
|
|
TWI395754B
(zh)
|
2006-04-24 |
2013-05-11 |
Amgen Inc |
人類化之c-kit抗體
|
|
CA2652733C
(en)
|
2006-05-25 |
2016-06-21 |
Glaxo Group Limited |
Modified humanised anti-interleukin-18 antibodies
|
|
HRP20120175T1
(hr)
|
2006-06-02 |
2012-03-31 |
Regeneron Pharmaceuticals |
Antitijela s visokim afinitetom za humani il-6 receptor
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
KR20090024243A
(ko)
|
2006-06-08 |
2009-03-06 |
추가이 세이야쿠 가부시키가이샤 |
염증성 질환의 예방 또는 치료제
|
|
ES2415655T3
(es)
*
|
2006-06-15 |
2013-07-26 |
The Board Of Trustees Of The University Of Arkansas |
Anticuerpos monoclonales que reconocen selectivamente Metanfetamina y compuestos similares a Metanfetamina
|
|
EP2035456A1
(en)
|
2006-06-22 |
2009-03-18 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
PE20080943A1
(es)
|
2006-06-23 |
2008-09-27 |
Smithkline Beecham Corp |
Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8
|
|
AR062223A1
(es)
|
2006-08-09 |
2008-10-22 |
Glycart Biotechnology Ag |
Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
|
|
AU2007285976B2
(en)
|
2006-08-14 |
2011-08-18 |
Xencor, Inc |
Optimized antibodies that target CD19
|
|
HRP20130320T1
(en)
|
2006-09-05 |
2013-05-31 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
|
CA2662340C
(en)
|
2006-09-08 |
2016-08-02 |
Medimmune, Llc |
Humanized anti-cd19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
|
|
JP5562031B2
(ja)
|
2006-09-18 |
2014-07-30 |
ゼンコー・インコーポレイテッド |
Hm1.24を標的とする最適化抗体
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
WO2008121160A2
(en)
|
2006-11-21 |
2008-10-09 |
Xencor, Inc. |
Optimized antibodies that target cd5
|
|
CN100455598C
(zh)
|
2006-11-29 |
2009-01-28 |
中国抗体制药有限公司 |
功能人源化抗人cd20抗体及其应用
|
|
WO2008091798A2
(en)
|
2007-01-22 |
2008-07-31 |
Xencor, Inc. |
Optimized ca9 antibodies and methods of using the same
|
|
EP2125893A2
(en)
|
2007-01-23 |
2009-12-02 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
|
AU2008208321B2
(en)
|
2007-01-23 |
2013-03-21 |
Chugai Seiyaku Kabushiki Kaisha |
Chronic rejection inhibitor
|
|
WO2008090960A1
(ja)
|
2007-01-24 |
2008-07-31 |
Kyowa Hakko Kirin Co., Ltd. |
ガングリオシドgm2に特異的に結合する遺伝子組換え抗体組成物
|
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
|
WO2008098115A2
(en)
|
2007-02-07 |
2008-08-14 |
Xencor, Inc. |
Optimized igf-1r antibodies and methods of using the same
|
|
ATE494306T1
(de)
*
|
2007-02-14 |
2011-01-15 |
Vaccinex Inc |
Humanisierte anti-cd100-antikörper
|
|
DK2426144T3
(en)
|
2007-02-23 |
2019-01-07 |
Merck Sharp & Dohme |
Manipulated Anti-IL-23P19 Antibodies
|
|
WO2008114733A1
(ja)
|
2007-03-16 |
2008-09-25 |
Kyowa Hakko Kirin Co., Ltd. |
抗Claudin-4抗体
|
|
EP2129681A2
(en)
|
2007-03-22 |
2009-12-09 |
Novartis Ag |
C5 antigens and uses thereof
|
|
US8114967B2
(en)
|
2007-03-27 |
2012-02-14 |
Sea Lane Biotechnologies Llc |
Constructs and libraries comprising antibody surrogate light chain sequences
|
|
WO2008119353A1
(en)
|
2007-03-29 |
2008-10-09 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
|
CL2008001071A1
(es)
|
2007-04-17 |
2009-05-22 |
Smithkline Beecham Corp |
Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
|
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
|
US20090252729A1
(en)
|
2007-05-14 |
2009-10-08 |
Farrington Graham K |
Single-chain Fc (scFc) regions, binding polypeptides comprising same, and methods related thereto
|
|
EP2176298B1
(en)
|
2007-05-30 |
2017-11-15 |
Xencor, Inc. |
Methods and compositions for inhibiting cd32b expressing cells
|
|
AU2008255352B2
(en)
|
2007-05-31 |
2014-05-22 |
Genmab A/S |
Stable IgG4 antibodies
|
|
US20100291023A1
(en)
|
2007-05-31 |
2010-11-18 |
Genmab A/S |
Method for extending the half-life of exogenous or endogenous soluble molecules
|
|
KR101530723B1
(ko)
|
2007-06-25 |
2015-06-22 |
에스바테크 - 어 노바티스 컴파니 엘엘씨 |
단일 쇄 항체의 서열에 기초한 공학처리 및 최적화
|
|
RU2540150C2
(ru)
|
2007-06-25 |
2015-02-10 |
Эсбатек, Эн Элкон Биомедикал Рисёрч Юнит Ллк |
Способы модификации антител и модифицированные антитела с улучшенными функциональными свойствами
|
|
MX2010000537A
(es)
|
2007-07-17 |
2010-03-25 |
Medarex Inc |
Anticuerpos monoclonales contra glipicano-3.
|
|
EP3246045B1
(en)
|
2007-07-26 |
2025-09-03 |
Osaka University |
Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient
|
|
US20110105724A1
(en)
|
2007-08-16 |
2011-05-05 |
Stephanie Jane Clegg |
Novel compounds
|
|
EP2197490A2
(en)
|
2007-08-28 |
2010-06-23 |
Biogen Idec MA, Inc. |
Compositions that bind multiple epitopes of igf-1r
|
|
WO2009032145A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Anti-igf-1r antibodies and uses thereof
|
|
EP2031064A1
(de)
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
|
ES3006441T3
(en)
|
2007-09-14 |
2025-03-18 |
Amgen Inc |
Homogeneous antibody populations
|
|
KR101922788B1
(ko)
|
2007-09-26 |
2018-11-27 |
추가이 세이야쿠 가부시키가이샤 |
항체 정상영역 개변체
|
|
MX2010003329A
(es)
|
2007-09-26 |
2010-04-27 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti-receptor de il-6.
|
|
JP5334319B2
(ja)
|
2007-09-26 |
2013-11-06 |
中外製薬株式会社 |
Cdrのアミノ酸置換により抗体の等電点を改変する方法
|
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
|
KR20100085067A
(ko)
|
2007-09-28 |
2010-07-28 |
추가이 세이야쿠 가부시키가이샤 |
혈장 중 반응속도가 개선된 항-글리피칸-3 항체
|
|
RU2490025C2
(ru)
|
2007-10-02 |
2013-08-20 |
Чугаи Сейяку Кабусики Кайся |
Терапевтические средства, используемые против реакции трансплантат против хозяина, содержащие в качестве активного ингредиента ингибитор рецептора интерлейкина-6
|
|
KR100888133B1
(ko)
|
2007-10-02 |
2009-03-13 |
에스케이에너지 주식회사 |
4종의 금속성분으로 구성된 다성분계 비스무스몰리브데이트 촉매 제조방법 및 상기촉매를 이용하여1,3-부타디엔을 제조하는 방법
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
JP2011500756A
(ja)
|
2007-10-22 |
2011-01-06 |
メルク セローノ ソシエテ アノニム |
Fc融合タンパク質を精製する方法
|
|
JP5314033B2
(ja)
|
2007-10-22 |
2013-10-16 |
メルク セローノ ソシエテ アノニム |
突然変異IgGFcフラグメントと融合した単一IFN−ベータ
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
PE20091024A1
(es)
*
|
2007-11-15 |
2009-08-12 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos monoclonales que se unen a anexelekto y sus usos
|
|
MX2010006097A
(es)
|
2007-12-05 |
2010-08-04 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para tratar el prurito.
|
|
EP2236604B1
(en)
*
|
2007-12-05 |
2016-07-06 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-nr10 antibody and use thereof
|
|
KR101672271B1
(ko)
|
2007-12-18 |
2016-11-03 |
바이오얼라이언스 씨.브이. |
암세포에서 발현된 cd-43 및 cea 상의 탄수화물 함유 에피토프를 인식하는 항체 및 그것의 사용 방법
|
|
ES2742268T3
(es)
|
2007-12-26 |
2020-02-13 |
Xencor Inc |
Variantes de Fc con unión alterada a FcRn
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
AU2009204501B2
(en)
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
CA2710439C
(en)
|
2008-01-18 |
2016-04-12 |
Stichting Sanquin Bloedvoorziening |
Methods for increasing the therapeutic efficacy of immunoglobulin g class 3 (igg3) antibodies
|
|
US20110183861A1
(en)
|
2008-01-29 |
2011-07-28 |
Ablynn N.V. |
Methods to stabilize proteins and polypeptides
|
|
BRPI0907735B1
(pt)
|
2008-02-08 |
2021-10-05 |
Astrazeneca Ab |
Anticorpo monoclonal de classe igg modificado específico para ifnar1, ácido nucleico isolado e composição farmacêutica
|
|
WO2009125825A1
(ja)
|
2008-04-11 |
2009-10-15 |
中外製薬株式会社 |
複数分子の抗原に繰り返し結合する抗原結合分子
|
|
AU2015227424A1
(en)
|
2008-04-11 |
2015-10-01 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
|
ES2487846T3
(es)
|
2008-05-01 |
2014-08-25 |
Amgen, Inc. |
Anticuerpos anti-hepcindina y métodos de uso
|
|
CN102088995B
(zh)
|
2008-05-14 |
2016-01-20 |
维多利亚农业服务控股公司 |
血管生成素和血管生成素激动剂用于治疗疾病和障碍的用途
|
|
CN102256623A
(zh)
|
2008-06-05 |
2011-11-23 |
独立行政法人国立癌症研究中心 |
神经浸润抑制剂
|
|
AU2009279197B2
(en)
|
2008-08-05 |
2013-12-12 |
Novartis Ag |
Compositions and methods for antibodies targeting complement protein C5
|
|
AU2009293143C1
(en)
|
2008-09-17 |
2015-07-23 |
Xencor, Inc. |
Novel compositons and methods for treating IgE-mediated disorders
|
|
JP5028372B2
(ja)
|
2008-09-26 |
2012-09-19 |
京セラドキュメントソリューションズ株式会社 |
画像処理装置、画像処理方法及び画像処理プログラム
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
JP5229888B2
(ja)
|
2008-09-30 |
2013-07-03 |
独立行政法人産業技術総合研究所 |
弱酸性域での易解離性を向上したプロテインa変異型タンパク質及び抗体捕捉剤
|
|
EA032828B1
(ru)
|
2008-10-10 |
2019-07-31 |
Аптево Рисёрч Энд Девелопмент Ллс |
Иммунотерапевтические средства против комплекса tcr
|
|
BRPI0914091B1
(pt)
|
2008-10-14 |
2022-05-10 |
Genentech Inc |
Igg variante, composição farmacêutica, kit e usos de um igg variante
|
|
EP2894166A1
(en)
|
2008-11-10 |
2015-07-15 |
Alexion Pharmaceuticals, Inc. |
Methods and compositions for treating complement-associated disorders
|
|
JP5807300B2
(ja)
|
2008-11-18 |
2015-11-10 |
株式会社シノテスト |
試料中のc反応性蛋白質の測定方法及び測定試薬
|
|
JP5898496B2
(ja)
|
2008-11-25 |
2016-04-06 |
アルダーバイオ ホールディングス エルエルシー |
Il−6に対する抗体およびその使用
|
|
WO2010064090A1
(en)
|
2008-12-02 |
2010-06-10 |
Pierre Fabre Medicament |
Process for the modulation of the antagonistic activity of a monoclonal antibody
|
|
AR074438A1
(es)
|
2008-12-02 |
2011-01-19 |
Pf Medicament |
Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal
|
|
KR20160062207A
(ko)
|
2008-12-05 |
2016-06-01 |
추가이 세이야쿠 가부시키가이샤 |
항nr10 항체 및 그의 이용
|
|
TW201029662A
(en)
|
2008-12-19 |
2010-08-16 |
Glaxo Group Ltd |
Novel antigen binding proteins
|
|
US20100189651A1
(en)
|
2009-01-12 |
2010-07-29 |
Cytomx Therapeutics, Llc |
Modified antibody compositions, methods of making and using thereof
|
|
US20120149875A1
(en)
|
2009-01-12 |
2012-06-14 |
Ge Healthcare Bio-Sciences Ab |
Affinity chromatography matrix
|
|
EP2389192A4
(en)
|
2009-01-23 |
2013-01-16 |
Biogen Idec Inc |
STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHOD OF USE
|
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
|
US20120071634A1
(en)
|
2009-03-19 |
2012-03-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody Constant Region Variant
|
|
WO2010107110A1
(ja)
|
2009-03-19 |
2010-09-23 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
RU2565809C2
(ru)
|
2009-03-19 |
2015-10-20 |
Чугаи Сейяку Кабусики Кайся |
Фармацевтический состав, содержащий молекулы антител с улучшенными свойствами
|
|
KR101314880B1
(ko)
|
2009-03-19 |
2013-10-04 |
추가이 세이야쿠 가부시키가이샤 |
관절류머티즘 치료제
|
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
|
JP5616428B2
(ja)
|
2009-04-07 |
2014-10-29 |
ロシュ グリクアート アクチェンゲゼルシャフト |
三価の二重特異性抗体
|
|
AU2010201495B2
(en)
|
2009-04-16 |
2012-04-12 |
Accenture Global Services Limited |
Touchpoint customization system
|
|
WO2010129304A2
(en)
|
2009-04-27 |
2010-11-11 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
EP2431393B1
(en)
|
2009-05-15 |
2018-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-axl antibody
|
|
US8609097B2
(en)
|
2009-06-10 |
2013-12-17 |
Hoffmann-La Roche Inc. |
Use of an anti-Tau pS422 antibody for the treatment of brain diseases
|
|
NZ597259A
(en)
|
2009-06-23 |
2014-04-30 |
Alexion Pharma Inc |
Bispecific antibodies that bind to complement proteins
|
|
US8945511B2
(en)
|
2009-06-25 |
2015-02-03 |
Paul Weinberger |
Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
|
|
MY164121A
(en)
|
2009-06-26 |
2017-11-30 |
Regeneron Pharma |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
GB0914691D0
(en)
|
2009-08-21 |
2009-09-30 |
Lonza Biologics Plc |
Immunoglobulin variants
|
|
WO2011025964A2
(en)
|
2009-08-29 |
2011-03-03 |
Abbott Laboratories |
Therapeutic dll4 binding proteins
|
|
CA3067609A1
(en)
|
2009-09-03 |
2011-03-10 |
Merck Sharp & Dohme Corp. |
Anti-gitr antibodies
|
|
EP2481752B1
(en)
*
|
2009-09-24 |
2016-11-09 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
|
US8568726B2
(en)
|
2009-10-06 |
2013-10-29 |
Medimmune Limited |
RSV specific binding molecule
|
|
NZ599148A
(en)
|
2009-10-06 |
2014-08-29 |
Medimmune Ltd |
Rsv-specific binding molecule
|
|
TR201804897T4
(tr)
|
2009-10-07 |
2018-06-21 |
Macrogenics Inc |
Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler
|
|
JP6095368B2
(ja)
|
2009-10-27 |
2017-03-15 |
ユセベ ファルマ ソシエテ アノニム |
機能改変するNav1.7抗体
|
|
CN101875696B
(zh)
|
2009-11-11 |
2012-02-08 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗体及其制备方法与应用
|
|
EP2327725A1
(en)
|
2009-11-26 |
2011-06-01 |
InflaRx GmbH |
Anti-C5a binding moieties with high blocking activity
|
|
KR102380315B1
(ko)
|
2009-12-25 |
2022-03-29 |
추가이 세이야쿠 가부시키가이샤 |
폴리펩티드 다량체를 정제하기 위한 폴리펩티드의 개변방법
|
|
CN105693861A
(zh)
|
2009-12-29 |
2016-06-22 |
新兴产品开发西雅图有限公司 |
异二聚体结合蛋白及其应用
|
|
TWI505838B
(zh)
|
2010-01-20 |
2015-11-01 |
Chugai Pharmaceutical Co Ltd |
Stabilized antibody solution containing
|
|
WO2011091181A1
(en)
|
2010-01-20 |
2011-07-28 |
Tolerx, Inc. |
Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
|
|
US9023997B2
(en)
|
2010-01-20 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Anti-ILT5 antibodies and ILT5-binding antibody fragments
|
|
WO2011094593A2
(en)
|
2010-01-28 |
2011-08-04 |
Ab Biosciences, Inc. |
Novel lowered affinity antibodies and methods of marking the same
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
US20120315267A1
(en)
|
2010-02-09 |
2012-12-13 |
Glaxosmithkline Llc |
Novel uses
|
|
SMT202000572T1
(it)
|
2010-02-19 |
2021-01-05 |
Xencor Inc |
Nuove immunoadesine ctla4-ig
|
|
SG183541A1
(en)
|
2010-03-01 |
2012-10-30 |
Alexion Pharma Inc |
Methods and compositions for treating degos' disease
|
|
EP2543727B1
(en)
|
2010-03-02 |
2016-08-31 |
Kyowa Hakko Kirin Co., Ltd. |
Modified antibody composition
|
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
TW201206466A
(en)
|
2010-03-11 |
2012-02-16 |
Rinat Neuroscience Corp |
Antibodies with pH dependent antigen binding
|
|
JP2011184418A
(ja)
|
2010-03-11 |
2011-09-22 |
Tokyo Institute Of Technology |
親和性可変抗体
|
|
KR20150002894A
(ko)
|
2010-03-11 |
2015-01-07 |
리나트 뉴로사이언스 코프. |
pH 의존성 항원 결합을 갖는 항체
|
|
TWI667257B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
JP5998050B2
(ja)
|
2010-03-31 |
2016-09-28 |
Jsr株式会社 |
アフィニティークロマトグラフィー用充填剤
|
|
CN110066339A
(zh)
|
2010-04-20 |
2019-07-30 |
根马布股份公司 |
含异二聚体抗体fc的蛋白及其制备方法
|
|
BR112012027001A2
(pt)
|
2010-04-23 |
2016-07-19 |
Genentech Inc |
produção de proteínas heteromultiméricas
|
|
US20140206849A1
(en)
|
2010-04-30 |
2014-07-24 |
Alexion Pharmaceuticals, Inc. |
Antibodies having reduced immunogenicity in a human
|
|
JP6022444B2
(ja)
|
2010-05-14 |
2016-11-09 |
ライナット ニューロサイエンス コーポレイション |
ヘテロ二量体タンパク質ならびにそれを生産および精製するための方法
|
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
|
US20130149302A1
(en)
|
2010-05-28 |
2013-06-13 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for pancreatic cancer
|
|
TW201210612A
(en)
|
2010-06-03 |
2012-03-16 |
Glaxo Group Ltd |
Humanised antigen binding proteins
|
|
JP5953303B2
(ja)
|
2010-07-29 |
2016-07-20 |
ゼンコア インコーポレイテッド |
改変された等電点を有する抗体
|
|
EP2603526A1
(en)
|
2010-08-13 |
2013-06-19 |
Medimmune Limited |
Monomeric polypeptides comprising variant fc regions and methods of use
|
|
JP2013537425A
(ja)
|
2010-08-16 |
2013-10-03 |
アムジエン・インコーポレーテツド |
ミオスタチンに結合するポリペプチド、組成物および方法
|
|
EP2614086A1
(en)
|
2010-09-08 |
2013-07-17 |
Halozyme, Inc. |
Methods for assessing and identifying or evolving conditionally active therapeutic proteins
|
|
WO2012032181A2
(en)
|
2010-09-10 |
2012-03-15 |
Allozyne, Inc |
Novel antibody derivatives
|
|
HUE047228T2
(hu)
|
2010-11-05 |
2020-04-28 |
Zymeworks Inc |
Stabil heterodimer antitest-kialakítás az FC doménben mutációval
|
|
CN104998254A
(zh)
|
2010-11-08 |
2015-10-28 |
基因技术公司 |
皮下施用的抗-il-6受体抗体
|
|
KR101962483B1
(ko)
|
2010-11-17 |
2019-03-29 |
추가이 세이야쿠 가부시키가이샤 |
혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
|
|
EP4231014A3
(en)
|
2010-11-30 |
2024-08-14 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
|
|
PT2647707T
(pt)
|
2010-11-30 |
2018-11-15 |
Chugai Pharmaceutical Co Ltd |
Agente terapêutico indutor de toxicidade
|
|
CA2822288A1
(en)
|
2010-12-22 |
2012-06-28 |
Medimmune, Llc |
Anti-c5/c5a/c5adesr antibodies and fragments
|
|
US20140080153A1
(en)
|
2011-01-07 |
2014-03-20 |
Chugai Seiyaku Kabushiki Kaisha |
Method for improving physical properties of antibody
|
|
CA2827923C
(en)
|
2011-02-25 |
2021-11-23 |
Chugai Seiyaku Kabushiki Kaisha |
Fc.gamma.riib-specific fc antibody
|
|
WO2012132067A1
(ja)
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
|
KR102899019B1
(ko)
|
2011-03-30 |
2025-12-10 |
추가이 세이야쿠 가부시키가이샤 |
항원 결합 분자의 혈장 체류성과 면역원성을 개변하는 방법
|
|
EP3825325A3
(en)
|
2011-03-30 |
2021-10-13 |
Chugai Seiyaku Kabushiki Kaisha |
Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
|
|
US20140112883A1
(en)
|
2011-04-20 |
2014-04-24 |
Liquidating Trust |
Methods for reducing an adverse immune response to a foreign antigen in a human subject with anti-cd4 antibodies or cd4-binding fragments thereof or cd4-binding molecules
|
|
US8778345B2
(en)
|
2011-04-29 |
2014-07-15 |
Apexigen, Inc. |
Anti-CD40 antibodies
|
|
RS60541B1
(sr)
|
2011-05-04 |
2020-08-31 |
Omeros Corp |
Kompozicije za inhibiciju masp-2 zavisne aktivacije komplementa
|
|
HRP20190756T1
(hr)
|
2011-05-21 |
2019-06-14 |
Macrogenics, Inc. |
Cd3-vezujuće molekule sposobne za vezanje za humani i nehumani cd3
|
|
CA2839986A1
(en)
|
2011-06-20 |
2012-12-27 |
St. Louis University |
Targeting the neuromuscular junction for treatment
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
|
CA2850194C
(en)
|
2011-09-30 |
2023-03-21 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule for promoting elimination of antigens
|
|
TW201817745A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
RU2722829C9
(ru)
|
2011-09-30 |
2020-09-22 |
Чугаи Сейяку Кабусики Кайся |
Антигенсвязывающая молекула, индуцирующая иммунный ответ на антиген-мишень
|
|
EP2762564B1
(en)
|
2011-09-30 |
2020-09-16 |
Chugai Seiyaku Kabushiki Kaisha |
Ion concentration-dependent binding molecule library
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
KR102049803B1
(ko)
|
2011-10-27 |
2019-11-29 |
젠맵 에이/에스 |
이종이량체 단백질의 생산
|
|
KR102398736B1
(ko)
|
2011-10-31 |
2022-05-16 |
추가이 세이야쿠 가부시키가이샤 |
중쇄와 경쇄의 회합이 제어된 항원 결합 분자
|
|
JP6326371B2
(ja)
|
2011-11-04 |
2018-05-16 |
ザイムワークス,インコーポレイテッド |
Fcドメインにおける変異を有する安定なヘテロ二量体抗体デザイン
|
|
CN104080909A
(zh)
|
2011-11-30 |
2014-10-01 |
中外制药株式会社 |
包含进入细胞内以形成免疫复合体的搬运体(载体)的药物
|
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
|
TWI877445B
(zh)
|
2012-02-24 |
2025-03-21 |
日商中外製藥股份有限公司 |
經FcγRIIB促進抗原消失之抗原結合分子
|
|
AU2013229613B2
(en)
|
2012-03-08 |
2015-07-30 |
F. Hoffmann-La Roche Ag |
Abeta antibody formulation
|
|
DK2825559T3
(da)
|
2012-03-13 |
2019-06-03 |
Novimmune Sa |
Letisolerbare bispecifikke antistoffer med nativt immunoglobulinformat
|
|
EP2825036B1
(en)
|
2012-03-16 |
2018-05-02 |
Regeneron Pharmaceuticals, Inc. |
Histidine engineered light chain antibodies and genetically modified rodents for generating the same
|
|
HUE045537T2
(hu)
|
2012-03-16 |
2019-12-30 |
Regeneron Pharma |
PH-érzékeny immunglobulin-szekvenciákat expresszáló rágcsálók
|
|
AU2013237929B2
(en)
|
2012-03-29 |
2017-09-14 |
Novimmune S.A. |
Anti-TLR4 antibodies and uses thereof
|
|
JP6280031B2
(ja)
|
2012-03-29 |
2018-02-14 |
中外製薬株式会社 |
抗lamp5抗体およびその利用
|
|
TWI619729B
(zh)
|
2012-04-02 |
2018-04-01 |
再生元醫藥公司 |
抗-hla-b*27抗體及其用途
|
|
EP2839019A4
(en)
|
2012-04-20 |
2016-03-30 |
Emergent Product Dev Seattle |
CD3 BINDING POLYPEPTIDES
|
|
WO2013157953A1
(en)
|
2012-04-20 |
2013-10-24 |
Merus B.V. |
Methods and means for the production of ig-like molecules
|
|
WO2013166099A1
(en)
|
2012-05-01 |
2013-11-07 |
Glaxosmithkline Llc |
Novel antibodies
|
|
US9255154B2
(en)
|
2012-05-08 |
2016-02-09 |
Alderbio Holdings, Llc |
Anti-PCSK9 antibodies and use thereof
|
|
US20140154270A1
(en)
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
|
CN104487457B
(zh)
|
2012-05-30 |
2018-01-26 |
中外制药株式会社 |
靶组织特异性抗原结合分子
|
|
ES2856272T3
(es)
|
2012-05-30 |
2021-09-27 |
Chugai Pharmaceutical Co Ltd |
Molécula de unión a antígenos para eliminar antígenos agregados
|
|
US9409994B2
(en)
|
2012-06-01 |
2016-08-09 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
High-affinity monoclonal antibodies to glypican-3 and use thereof
|
|
PE20150223A1
(es)
|
2012-06-15 |
2015-02-11 |
Pfizer |
Anticuerpos antagonistas mejorados contra factor-8 de crecimiento y diferenciacion y usos de los mismos
|
|
BR112015000167B1
(pt)
|
2012-07-06 |
2021-11-23 |
Genmab B.V. |
Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante
|
|
JP6309521B2
(ja)
|
2012-08-13 |
2018-04-11 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
pH依存性結合特性を有する抗PCSK9抗体
|
|
US9133269B2
(en)
|
2012-08-24 |
2015-09-15 |
Anaptysbio, Inc. |
Humanized antibodies directed against complement protein C5
|
|
DK2889377T3
(da)
|
2012-08-24 |
2020-03-30 |
Chugai Pharmaceutical Co Ltd |
Fc?RIIb-Specifik Fc-regionsvariant
|
|
TWI595007B
(zh)
|
2012-09-10 |
2017-08-11 |
Neotope Biosciences Ltd |
抗mcam抗體及相關使用方法
|
|
US20150297820A1
(en)
|
2012-09-10 |
2015-10-22 |
Kaneka Corporation |
Adsorbent
|
|
AU2013315482B2
(en)
|
2012-09-13 |
2018-03-15 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind to myostatin
|
|
JOP20200236A1
(ar)
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
TW201418707A
(zh)
|
2012-09-21 |
2014-05-16 |
Alexion Pharma Inc |
補體組分c5拮抗劑之篩選分析
|
|
PT2900694T
(pt)
|
2012-09-27 |
2018-11-13 |
Merus Nv |
Anticorpos de igg biespecíficos como ativadores de células t
|
|
JP6273205B2
(ja)
|
2012-10-05 |
2018-01-31 |
協和発酵キリン株式会社 |
ヘテロダイマータンパク質組成物
|
|
CA2889951C
(en)
|
2012-11-02 |
2023-04-18 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
|
SG10201704616SA
(en)
|
2012-11-06 |
2017-07-28 |
Scholar Rock Inc |
Compositions and methods for modulating cell signaling
|
|
CN103833852A
(zh)
|
2012-11-23 |
2014-06-04 |
上海市肿瘤研究所 |
针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体
|
|
EA038645B1
(ru)
|
2012-12-21 |
2021-09-28 |
Авео Фармасьютикалз, Инк. |
Антитела к gdf15
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
KR20150110659A
(ko)
|
2013-01-24 |
2015-10-02 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
Tnf-알파 항원-결합 단백질
|
|
KR101638931B1
(ko)
|
2013-01-31 |
2016-07-12 |
서울대학교산학협력단 |
보체 관련 질환의 예방 및 치료를 위한 c5 항체 및 방법
|
|
US9481725B2
(en)
|
2013-03-14 |
2016-11-01 |
Alderbio Holdings, Llc |
Antibodies to HGF and compositions containing
|
|
US20160031985A1
(en)
|
2013-03-15 |
2016-02-04 |
Katherine S. Bowdish |
Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use
|
|
EP3587448B1
(en)
|
2013-03-15 |
2021-05-19 |
Xencor, Inc. |
Heterodimeric proteins
|
|
HK1220367A1
(zh)
|
2013-03-15 |
2017-05-05 |
Amgen Inc. |
人类受试者中的肌抑素拮抗作用
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
EP2970436B1
(en)
|
2013-03-15 |
2018-09-05 |
AbbVie Biotherapeutics Inc. |
Fc variants
|
|
US20160051673A1
(en)
|
2013-03-29 |
2016-02-25 |
Alexion Pharmaceuticals, Inc. |
Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
|
|
SG11201508170TA
(en)
|
2013-04-02 |
2015-11-27 |
Chugai Pharmaceutical Co Ltd |
Fc REGION VARIANT
|
|
EP3816625B1
(en)
|
2013-05-06 |
2025-09-17 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
|
CA2911600C
(en)
|
2013-05-17 |
2025-02-04 |
Centre National De La Recherche Scientifique (Cnrs) |
Antibodies against CXCL1, CXCL7 and CXCL8 and their applications
|
|
AU2014273817B2
(en)
|
2013-05-31 |
2019-03-14 |
Zymeworks Bc Inc. |
Heteromultimers with reduced or silenced effector function
|
|
HRP20220553T1
(hr)
|
2013-07-25 |
2022-06-10 |
Cytomx Therapeutics Inc. |
Polispecifična protutijela, polispecifična protutijela koja se mogu aktivirati i postupci uporabe navedenih protutijela
|
|
US20160200818A1
(en)
|
2013-08-14 |
2016-07-14 |
Novartis Ag |
Methods of treating Sporadic Inclusion Body Myositis
|
|
EP3033093A1
(en)
|
2013-08-16 |
2016-06-22 |
Alexion Pharmaceuticals, Inc. |
Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant
|
|
US10208094B2
(en)
|
2013-09-04 |
2019-02-19 |
Protenova Co., Ltd. |
Multimeric immunoglobulin-binding domain
|
|
EP2853898B1
(en)
|
2013-09-27 |
2017-01-04 |
Medizinische Hochschule Hannover |
Analysis of myostatin in serum
|
|
RU2730594C2
(ru)
|
2013-09-27 |
2020-08-24 |
Чугаи Сейяку Кабусики Кайся |
Способ получения полипептидного гетеромультимера
|
|
WO2015046554A1
(ja)
|
2013-09-30 |
2015-04-02 |
中外製薬株式会社 |
改変されたヘルパーファージを用いて抗原結合分子を作製する方法
|
|
NZ720161A
(en)
|
2013-11-04 |
2022-07-29 |
Ichnos Sciences SA |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
|
CN105992951A
(zh)
|
2014-01-27 |
2016-10-05 |
诺华股份有限公司 |
预测肌萎缩的生物标志物、方法和用途
|
|
AU2015218903B2
(en)
|
2014-02-20 |
2020-10-15 |
Allergan, Inc. |
Complement component C5 antibodies
|
|
NZ631007A
(en)
|
2014-03-07 |
2015-10-30 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
|
AU2015244814B2
(en)
|
2014-04-07 |
2020-12-24 |
Chugai Seiyaku Kabushiki Kaisha |
Immunoactivating antigen-binding molecule
|
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
|
EA201692287A1
(ru)
|
2014-05-13 |
2017-06-30 |
Чугаи Сеияку Кабушики Каиша |
Антигенсвязывающая молекула, перенаправляющая т-клетки на клетки, обладающие иммуносупрессорной функцией
|
|
TWI831106B
(zh)
|
2014-06-20 |
2024-02-01 |
日商中外製藥股份有限公司 |
用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
|
|
ES2926376T3
(es)
|
2014-06-30 |
2022-10-25 |
Merck Patent Gmbh |
Anticuerpos anti-TNFa con unión al antígeno dependiente del pH
|
|
AR101262A1
(es)
|
2014-07-26 |
2016-12-07 |
Regeneron Pharma |
Plataforma de purificación para anticuerpos biespecíficos
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
JP6630036B2
(ja)
|
2014-09-30 |
2020-01-15 |
Jsr株式会社 |
標的物の精製方法、及び、ミックスモード用担体
|
|
JP6706617B2
(ja)
|
2014-11-06 |
2020-06-10 |
スカラー ロック インコーポレイテッドScholar Rock,Inc. |
抗プロ/潜在型−ミオスタチン抗体およびその使用
|
|
WO2016073906A2
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Transforming growth factor-related immunoassays
|
|
CA2969800A1
(en)
|
2014-12-08 |
2016-06-16 |
Novartis Ag |
Myostatin or activin antagonists for the treatment of sarcopenia
|
|
CN107207607B
(zh)
|
2014-12-19 |
2021-05-04 |
中外制药株式会社 |
抗-c5抗体及使用方法
|
|
TWI808330B
(zh)
|
2014-12-19 |
2023-07-11 |
日商中外製藥股份有限公司 |
抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法
|
|
WO2016117346A1
(en)
|
2015-01-22 |
2016-07-28 |
Chugai Seiyaku Kabushiki Kaisha |
A combination of two or more anti-c5 antibodies and methods of use
|
|
EA201791754A1
(ru)
|
2015-02-05 |
2019-01-31 |
Чугаи Сейяку Кабусики Кайся |
АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ
|
|
US10774148B2
(en)
|
2015-02-27 |
2020-09-15 |
Chugai Seiyaku Kabushiki Kaisha |
Composition for treating IL-6-related diseases
|
|
WO2016160756A2
(en)
|
2015-03-31 |
2016-10-06 |
Alexion Pharmaceuticlas, Inc. |
Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patents
|
|
EP3279216A4
(en)
|
2015-04-01 |
2019-06-19 |
Chugai Seiyaku Kabushiki Kaisha |
PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER
|
|
AU2016245887B2
(en)
|
2015-04-10 |
2021-09-23 |
Adimab, Llc. |
Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species
|
|
JP6877357B2
(ja)
|
2015-04-15 |
2021-05-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
Gdf8阻害剤を用いて、強度及び機能を増加させる方法
|
|
CN107454906B
(zh)
|
2015-04-17 |
2022-05-27 |
豪夫迈·罗氏有限公司 |
使用凝固因子和多特异性抗体的联合治疗
|
|
JP2018123055A
(ja)
|
2015-04-24 |
2018-08-09 |
公立大学法人奈良県立医科大学 |
血液凝固第viii因子(fviii)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第xi因子(fxi)異常症の予防および/または治療に用いられる医薬組成物
|
|
US20180311299A1
(en)
|
2015-05-01 |
2018-11-01 |
Alexion Pharmaceuticals, Inc. |
Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant
|
|
US20180142010A1
(en)
|
2015-06-26 |
2018-05-24 |
Alexion Pharmaceuticals, Inc. |
Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant
|
|
US10940126B2
(en)
|
2015-07-03 |
2021-03-09 |
Camilla Svensson |
Inhibition of IL-8 in the treatment of pain and/or bone loss
|
|
JP7107836B2
(ja)
|
2015-09-15 |
2022-07-27 |
スカラー ロック インコーポレイテッド |
抗プロ/潜在型ミオスタチン抗体およびその使用
|
|
TW202446797A
(zh)
|
2015-09-18 |
2024-12-01 |
日商中外製藥股份有限公司 |
Il-8結合抗體及其用途
|
|
TW201718014A
(zh)
|
2015-10-12 |
2017-06-01 |
諾華公司 |
C5抑制劑於移植相關微血管病之用途
|
|
KR20230027321A
(ko)
|
2015-12-18 |
2023-02-27 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
|
|
TW202344514A
(zh)
|
2015-12-18 |
2023-11-16 |
日商中外製藥股份有限公司 |
抗c5抗體及使用方法
|
|
JP7141336B2
(ja)
|
2015-12-25 |
2022-09-22 |
中外製薬株式会社 |
抗ミオスタチン抗体および使用方法
|
|
CN108368166B
(zh)
|
2015-12-28 |
2023-03-28 |
中外制药株式会社 |
提高含fc区多肽纯化效率的方法
|
|
CN109071645A
(zh)
|
2016-01-08 |
2018-12-21 |
供石公司 |
抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法
|
|
US20190023775A1
(en)
|
2016-01-11 |
2019-01-24 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment
|
|
JOP20170017B1
(ar)
|
2016-01-25 |
2021-08-17 |
Amgen Res Munich Gmbh |
تركيب صيدلي يتضمن تركيبات جسم مضاد ثنائي الاختصاص
|
|
WO2017132259A1
(en)
|
2016-01-25 |
2017-08-03 |
Shire Human Genetic Therapies, Inc. |
Anti-c5 antibodies with enhanced ph switch
|
|
TW202342540A
(zh)
|
2016-03-14 |
2023-11-01 |
日商中外製藥股份有限公司 |
用於癌之治療的細胞傷害誘導治療劑
|
|
JP6175590B1
(ja)
|
2016-03-14 |
2017-08-02 |
中外製薬株式会社 |
癌の治療に用いるための細胞傷害誘導治療剤
|
|
NZ746002A
(en)
|
2016-04-28 |
2025-08-29 |
Chugai Pharmaceutical Co Ltd |
Antibody-containing preparation
|
|
US10946036B2
(en)
|
2016-06-13 |
2021-03-16 |
Scholar Rock, Inc. |
Use of myostatin inhibitors and combination therapies
|
|
SG10202012243VA
(en)
|
2016-06-14 |
2021-01-28 |
Regeneron Pharma |
Anti-c5 antibodies and uses thereof
|
|
WO2017217524A1
(en)
|
2016-06-17 |
2017-12-21 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-c5 antibodies and methods of use
|
|
KR102680483B1
(ko)
|
2016-06-17 |
2024-07-01 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체 및 사용 방법
|
|
RU2766112C2
(ru)
|
2016-08-05 |
2022-02-08 |
Чугаи Сейяку Кабусики Кайся |
Композиция для профилактики или лечения связанных с il-8 заболеваний
|
|
UA129282C2
(uk)
|
2017-01-31 |
2025-03-12 |
Чугаі Сейяку Кабусікі Кайся |
Спосіб лікування або профілактики пов'язаних з c5 хвороб
|
|
AU2018236218B2
(en)
|
2017-03-14 |
2025-03-06 |
Bristol-Myers Squibb Company |
Antibodies binding to vista at acidic pH
|
|
WO2018181870A1
(ja)
|
2017-03-31 |
2018-10-04 |
公立大学法人奈良県立医科大学 |
血液凝固第viii因子の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第ix因子異常症の予防および/または治療に用いられる医薬組成物
|
|
CN111108118A
(zh)
|
2017-04-03 |
2020-05-05 |
因弗拉克斯有限责任公司 |
用C5a活性抑制剂治疗炎性疾病
|
|
BR112020005834A2
(pt)
|
2017-09-29 |
2020-09-24 |
Chugai Seiyaku Kabushiki Kaisha |
molécula multiespecífica de ligação ao antígeno tendo atividade de substituição de função de cofator do fator viii de coagulação sanguínea (fviii), e formulação farmacêutica contendo a referida molécula como ingrediente ativo
|
|
US12128101B2
(en)
|
2017-10-26 |
2024-10-29 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)
|
|
CN119161488A
(zh)
|
2017-11-01 |
2024-12-20 |
中外制药株式会社 |
具有降低的生物活性的抗体变体和同种型
|
|
SG11202005181RA
(en)
|
2017-12-04 |
2020-07-29 |
Ra Pharmaceuticals Inc |
Modulators of complement activity
|
|
KR20210038697A
(ko)
|
2018-08-01 |
2021-04-07 |
추가이 세이야쿠 가부시키가이샤 |
C5-관련 질환의 치료 또는 예방용 의약 조성물 및 c5-관련 질환을 치료 또는 예방하기 위한 방법
|
|
TW202104244A
(zh)
|
2019-04-10 |
2021-02-01 |
日商中外製藥股份有限公司 |
Fc區域改變抗體的純化方法
|
|
WO2022191306A1
(ja)
|
2021-03-12 |
2022-09-15 |
中外製薬株式会社 |
重症筋無力症の治療または予防用の医薬組成物
|
|
WO2023095305A1
(en)
|
2021-11-26 |
2023-06-01 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment of a demyelinating disease of the central nervous system (cns) with satralizumab
|
|
WO2023140269A1
(en)
|
2022-01-19 |
2023-07-27 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment of autoimmune encephalitis with satralizumab
|