SG10201704616SA - Compositions and methods for modulating cell signaling - Google Patents

Compositions and methods for modulating cell signaling

Info

Publication number
SG10201704616SA
SG10201704616SA SG10201704616SA SG10201704616SA SG10201704616SA SG 10201704616S A SG10201704616S A SG 10201704616SA SG 10201704616S A SG10201704616S A SG 10201704616SA SG 10201704616S A SG10201704616S A SG 10201704616SA SG 10201704616S A SG10201704616S A SG 10201704616SA
Authority
SG
Singapore
Prior art keywords
compositions
methods
cell signaling
modulating cell
modulating
Prior art date
Application number
SG10201704616SA
Inventor
Timothy Alan Springer
Leonard Ira Zon
Nagesh K Mahanthappa
Original Assignee
Scholar Rock Inc
Children’S Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scholar Rock Inc, Children’S Medical Center Corp filed Critical Scholar Rock Inc
Publication of SG10201704616SA publication Critical patent/SG10201704616SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201704616SA 2012-11-06 2013-11-06 Compositions and methods for modulating cell signaling SG10201704616SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261722969P 2012-11-06 2012-11-06
US201261722919P 2012-11-06 2012-11-06

Publications (1)

Publication Number Publication Date
SG10201704616SA true SG10201704616SA (en) 2017-07-28

Family

ID=50685303

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201704616SA SG10201704616SA (en) 2012-11-06 2013-11-06 Compositions and methods for modulating cell signaling
SG11201503271XA SG11201503271XA (en) 2012-11-06 2013-11-06 Compositions and methods for modulating cell signaling

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201503271XA SG11201503271XA (en) 2012-11-06 2013-11-06 Compositions and methods for modulating cell signaling

Country Status (10)

Country Link
US (2) US20150284455A1 (en)
EP (1) EP2916867A4 (en)
JP (3) JP2016500704A (en)
AU (3) AU2013341353B2 (en)
CA (2) CA2890733A1 (en)
IL (1) IL238488B (en)
MX (1) MX2015005675A (en)
SG (2) SG10201704616SA (en)
WO (1) WO2014074532A2 (en)
ZA (1) ZA201502884B (en)

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MX365235B (en) 2010-11-30 2019-05-28 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly.
JP6774164B2 (en) 2012-08-24 2020-10-21 中外製薬株式会社 Mouse FcγRII specific Fc antibody
US10919953B2 (en) 2012-08-24 2021-02-16 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific Fc region variant
WO2014141064A1 (en) 2013-03-13 2014-09-18 Novartis Ag Notch2 binding molecules for treating respiratory diseases
CN113621057A (en) 2013-04-02 2021-11-09 中外制药株式会社 Fc region variants
IL301607A (en) 2013-05-06 2023-05-01 Scholar Rock Inc Compositions and methods for growth factor modulation
CN107073090A (en) 2014-04-30 2017-08-18 哈佛学院董事会 With reference to vaccine device and kill cancer cell method
JP6706617B2 (en) * 2014-11-06 2020-06-10 スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． Anti-pro/latent-myostatin antibodies and uses thereof
EP3218005B1 (en) 2014-11-12 2023-01-04 Seagen Inc. Glycan-interacting compounds and methods of use
KR102650420B1 (en) * 2014-12-19 2024-03-21 추가이 세이야쿠 가부시키가이샤 Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
WO2016115345A1 (en) 2015-01-14 2016-07-21 The Brigham And Women's Hospital, Treatment of cancer with anti-lap monoclonal antibodies
US9969800B2 (en) 2015-02-05 2018-05-15 Chugai Seiyaku Kabushiki Kaisha IL-8 antibodies
WO2017015622A2 (en) * 2015-07-22 2017-01-26 Scholar Rock, Inc Gdf11 binding proteins and uses thereof
CN113896789A (en) 2015-09-15 2022-01-07 供石公司 Anti-pro/latent myostatin antibodies and uses thereof
DK3354729T3 (en) * 2015-09-24 2024-04-22 Daiichi Sankyo Co Ltd ANTI-GARP ANTI-STOCK
EP3373969A4 (en) 2015-11-12 2019-08-14 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
SG11201805709RA (en) 2016-01-08 2018-07-30 Scholar Rock Inc Anti-pro/latent myostatin antibodies and methods of use thereof
JP7138864B2 (en) 2016-02-06 2022-09-20 プレジデント アンド フェローズ オブ ハーバード カレッジ Recapitulation of the hematopoietic niche to reconstitute immunity
EA201891909A1 (en) 2016-03-11 2019-02-28 Сколар Рок, Инк. TGFβ1-BINDING IMMUNOGLOBULINS AND THEIR APPLICATION
AU2017240074B2 (en) * 2016-03-31 2020-01-02 Jiangsu Yahong Meditech Co., Ltd. Combinational uses of Nitroxoline and its analogues with chemotherapies and immunotherapies in the treatment of cancers
ES2830440T3 (en) 2016-06-13 2021-06-03 Scholar Rock Inc Use of myostatin inhibitors and combination therapies
CN115404196A (en) 2016-07-13 2022-11-29 哈佛学院院长等 Antigen presenting cell mimetic scaffolds and methods of making and using same
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of il-8 related diseases
WO2018053234A1 (en) * 2016-09-15 2018-03-22 Acceleron Pharma, Inc. Twisted gastrulation polypeptides and uses thereof
JP7198757B2 (en) 2017-01-06 2023-01-04 スカラー ロック インコーポレイテッド Methods for treating metabolic disorders by inhibiting myostatin activation
US11866506B2 (en) 2017-04-21 2024-01-09 Mellitus, Llc Anti-CD59 antibodies
PL3621694T3 (en) 2017-05-09 2024-02-05 Scholar Rock, Inc. Lrrc33 inhibitors and use thereof
EP3694552A1 (en) 2017-10-10 2020-08-19 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
EP3749365A4 (en) * 2018-01-29 2022-01-12 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
DK3677278T3 (en) 2018-07-11 2022-01-10 Scholar Rock Inc ISOFORM SELECTIVE TGFBETA1 INHIBITORS AND USE THEREOF
EP3863722A2 (en) 2018-10-10 2021-08-18 Tilos Theapeutics, Inc. Anti-lap antibody variants and uses thereof
BR112021015056A2 (en) 2019-01-30 2022-01-11 Scholar Rock Inc Specific inhibitors of tgf-beta ltbp complexes and uses thereof
US20240124889A1 (en) 2019-05-07 2024-04-18 Voyager Therapeutics, Inc. Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation
US20220308072A1 (en) 2019-08-12 2022-09-29 Voyager Therapeutics, Inc. High-sensitivity immunoassay for the detection of frataxin in biofluids
EP4021498A4 (en) 2019-08-28 2024-01-03 Chugai Seiyaku Kabushiki Kaisha Cross-species anti-latent tgf-beta 1 antibodies and methods of use
CN111474336B (en) * 2020-03-21 2023-07-28 南昌大学 Preparation method of nickel ferricyanide nanoparticle luminescent aptamer sensor and method for detecting 8-OhdG based on nickel ferricyanide nanoparticle luminescent aptamer sensor
WO2022099093A1 (en) * 2020-11-06 2022-05-12 President And Fellows Of Harvard College Scaffolds for enhancing neutrophils and uses thereof
US20220184114A1 (en) 2020-12-14 2022-06-16 Regeneron Pharmaceuticals, Inc. Methods Of Treating Metabolic Disorders And Cardiovascular Disease With Inhibin Subunit Beta E (INHBE) Inhibitors
CN113061575B (en) * 2021-03-25 2023-04-07 中国人民解放军陆军军医大学 Method for separating and purifying inherent lymphoid cells from colon inherent layer of old mouse
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Also Published As

Publication number Publication date
EP2916867A4 (en) 2016-10-05
IL238488A0 (en) 2015-06-30
ZA201502884B (en) 2016-01-27
JP2016500704A (en) 2016-01-14
MX2015005675A (en) 2016-02-03
CA2890733A1 (en) 2014-05-15
US20150284455A1 (en) 2015-10-08
AU2019264599A1 (en) 2019-12-05
CA3023553A1 (en) 2014-05-15
JP2019163317A (en) 2019-09-26
AU2013341353B2 (en) 2017-03-16
IL238488B (en) 2020-04-30
AU2017203805B2 (en) 2019-08-15
US20200024339A1 (en) 2020-01-23
AU2013341353A1 (en) 2015-05-28
JP2017132796A (en) 2017-08-03
SG11201503271XA (en) 2015-05-28
AU2017203805A1 (en) 2017-06-22
EP2916867A2 (en) 2015-09-16
WO2014074532A3 (en) 2014-06-26
WO2014074532A2 (en) 2014-05-15

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