DE602005020743D1 - Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern - Google Patents
Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpernInfo
- Publication number
- DE602005020743D1 DE602005020743D1 DE602005020743T DE602005020743T DE602005020743D1 DE 602005020743 D1 DE602005020743 D1 DE 602005020743D1 DE 602005020743 T DE602005020743 T DE 602005020743T DE 602005020743 T DE602005020743 T DE 602005020743T DE 602005020743 D1 DE602005020743 D1 DE 602005020743D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- treating osteoarthritis
- osteoarthritis
- treating
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54381404P | 2004-02-11 | 2004-02-11 | |
PCT/IB2005/000240 WO2005080429A2 (en) | 2004-02-11 | 2005-01-31 | Methods of treating osteoarthritis with anti-il-6 or anti-il6 receptor antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005020743D1 true DE602005020743D1 (de) | 2010-06-02 |
Family
ID=34885980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005020743T Active DE602005020743D1 (de) | 2004-02-11 | 2005-01-31 | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern |
Country Status (9)
Country | Link |
---|---|
US (2) | US20080145367A1 (de) |
EP (1) | EP1715891B2 (de) |
JP (1) | JP2008505054A (de) |
AT (1) | ATE464908T1 (de) |
BR (1) | BRPI0506679A (de) |
CA (1) | CA2555688C (de) |
DE (1) | DE602005020743D1 (de) |
ES (1) | ES2341461T5 (de) |
WO (1) | WO2005080429A2 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4342995A2 (de) | 2006-03-31 | 2024-03-27 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur kontrolle der blut-pharmazeutizität von antikörpern |
MX2008014804A (es) | 2006-06-02 | 2009-01-27 | Regeneron Pharma | Anticuerpos de afinidad elevada a receptor de il-6 humano. |
US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
CN101563365B (zh) | 2006-08-03 | 2012-10-31 | 瓦西尼斯公司 | 抗-il-6单克隆抗体及其用途 |
TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
WO2009010539A2 (de) * | 2007-07-19 | 2009-01-22 | Ablynx. N.V. | Receptor for interleukin-6 (il-6) form macaca fascicularis |
EP3127921A1 (de) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstition in cdr |
MX2010003450A (es) | 2007-09-26 | 2010-04-27 | Chugai Pharmaceutical Co Ltd | Region constante de anticuerpo modificada. |
JP2009092508A (ja) * | 2007-10-09 | 2009-04-30 | Norihiro Nishimoto | リウマチ治療剤の効果の予測方法 |
KR102269708B1 (ko) | 2008-04-11 | 2021-06-25 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
CN102089326B (zh) | 2008-05-13 | 2014-12-31 | 诺维莫尼公司 | 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
RU2011127334A (ru) | 2008-12-22 | 2013-01-27 | Де Юниверсити Оф Мельбурн | Лечение остеоартрита |
JP4885308B2 (ja) * | 2009-03-19 | 2012-02-29 | 中外製薬株式会社 | 改良された抗体分子を含有する製剤 |
WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
TWI646193B (zh) | 2009-03-19 | 2019-01-01 | 中外製藥股份有限公司 | 抗體恆定區域改變體 |
JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
TWI505838B (zh) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody solution containing |
AU2011337704B2 (en) | 2010-11-30 | 2017-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
EP2672997A4 (de) * | 2011-02-08 | 2015-05-06 | Abbvie Inc | Behandlung von osteoarthritis und schmerzen |
KR102147548B1 (ko) | 2011-02-25 | 2020-08-24 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb 특이적 Fc 항체 |
AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
EP3939996A1 (de) | 2011-09-30 | 2022-01-19 | Chugai Seiyaku Kabushiki Kaisha | Antigenbindende moleküle zur förderung der zersetzung von antigenen mit mehreren biologischen aktivitäten |
TWI589299B (zh) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
CN113416256A (zh) | 2011-11-30 | 2021-09-21 | 中外制药株式会社 | 包含进入细胞内以形成免疫复合体的搬运体(载体)的药物 |
WO2014200018A1 (ja) | 2013-06-11 | 2014-12-18 | 独立行政法人 国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
US20170266168A1 (en) * | 2014-09-18 | 2017-09-21 | Rush University Medical Center | Methods for preventing or treating osteoarthritis |
MA41294A (fr) | 2014-12-19 | 2017-11-08 | Chugai Pharmaceutical Co Ltd | Anticorps anti-myostatine, polypeptides contenant des variants de régions fc, et procédés d'utilisation |
EP3233921B1 (de) | 2014-12-19 | 2021-09-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5-antikörper und verfahren zur verwendung |
CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用 |
CA2972393A1 (en) | 2015-02-27 | 2016-09-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
ES2888801T3 (es) | 2015-05-19 | 2022-01-07 | Nat Center Neurology & Psychiatry | Método para determinar la aplicación de una terapia nueva en pacientes con esclerosis múltiple (EM) |
CN113117074A (zh) | 2015-07-31 | 2021-07-16 | 米迪缪尼有限公司 | 用于治疗海帕西啶介导的病症的方法 |
WO2017031151A1 (en) | 2015-08-18 | 2017-02-23 | Regeneron Pharmaceuticals, Inc. | Anti-pcsk9 inhibitory antibodies for treating patients with hyperlipidemia undergoing lipoprotein apheresis |
JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
CN116271014A (zh) | 2016-08-05 | 2023-06-23 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
WO2018139623A1 (en) | 2017-01-30 | 2018-08-02 | Chugai Seiyaku Kabushiki Kaisha | Anti-sclerostin antibodies and methods of use |
WO2018144773A1 (en) | 2017-02-01 | 2018-08-09 | Yale University | Treatment of diuretic resistance |
US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
EP3698808A4 (de) | 2017-10-20 | 2021-07-14 | Hyogo College Of Medicine | Anti-il-6 rezeptorantikörper enthaltende medizinische zusammensetzung zur verhinderung von postoperativer adhäsion |
US20190241650A1 (en) | 2018-01-05 | 2019-08-08 | Corvidia Therapeutics, Inc. | Methods for treating il-6 mediated inflammation without immunosuppression |
AU2020216978A1 (en) | 2019-01-31 | 2021-09-09 | Regeneron Pharmaceuticals, Inc. | Anti-il-6 receptor antibody for treating juvenile idiopathic arthritis |
US20220347182A1 (en) * | 2019-10-02 | 2022-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for the treatment of osteoarthritis |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT52962A (en) * | 1988-03-04 | 1990-09-28 | Sandoz Ag | Process for production of medical compositions eliminating bone-absorption and promoting forming of bones |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE122009000019I1 (de) * | 1991-04-25 | 2009-07-16 | Chugai Seiyaku K K 5 1 | Rekombinierte humane antikörper gegen den humanen interleukin-6 rezeptor |
US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
RU2147443C1 (ru) * | 1994-10-07 | 2000-04-20 | Чугаи Сейяку Кабусики Кайся | Лечебные средства против хронического ревматоидного артрита, содержащие антагонист il-6 в качестве эффективного компонента |
US5617790A (en) * | 1995-05-31 | 1997-04-08 | P.R. Graphics Limited | Apparatus for producing flexographic printing plates |
US20030202977A1 (en) * | 1998-11-16 | 2003-10-30 | New York University | Treatment of osteoarthritis |
AR035642A1 (es) * | 2000-05-26 | 2004-06-23 | Pharmacia Corp | Uso de una composicion de celecoxib para el alivio rapido del dolor |
EP2308888B1 (de) * | 2001-11-14 | 2017-03-01 | Janssen Biotech, Inc. | Anti-IL-6-Antikörper, Zusammensetzungen, Verfahren und Anwendungen |
-
2005
- 2005-01-31 BR BRPI0506679-4A patent/BRPI0506679A/pt not_active IP Right Cessation
- 2005-01-31 DE DE602005020743T patent/DE602005020743D1/de active Active
- 2005-01-31 CA CA2555688A patent/CA2555688C/en not_active Expired - Fee Related
- 2005-01-31 WO PCT/IB2005/000240 patent/WO2005080429A2/en active Search and Examination
- 2005-01-31 AT AT05702390T patent/ATE464908T1/de not_active IP Right Cessation
- 2005-01-31 US US10/588,911 patent/US20080145367A1/en not_active Abandoned
- 2005-01-31 ES ES05702390.5T patent/ES2341461T5/es active Active
- 2005-01-31 JP JP2006552709A patent/JP2008505054A/ja active Pending
- 2005-01-31 EP EP05702390.5A patent/EP1715891B2/de not_active Not-in-force
-
2010
- 2010-03-16 US US12/724,920 patent/US20100215654A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080145367A1 (en) | 2008-06-19 |
CA2555688A1 (en) | 2005-09-01 |
CA2555688C (en) | 2011-11-08 |
ES2341461T5 (es) | 2014-10-29 |
WO2005080429A2 (en) | 2005-09-01 |
ES2341461T3 (es) | 2010-06-21 |
EP1715891A2 (de) | 2006-11-02 |
BRPI0506679A (pt) | 2007-05-15 |
WO2005080429A3 (en) | 2006-02-23 |
US20100215654A1 (en) | 2010-08-26 |
ATE464908T1 (de) | 2010-05-15 |
EP1715891B2 (de) | 2014-08-13 |
EP1715891B1 (de) | 2010-04-21 |
JP2008505054A (ja) | 2008-02-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |