DE602005021684D1 - Verfahren zur herstellung von pimecrolimus - Google Patents
Verfahren zur herstellung von pimecrolimusInfo
- Publication number
- DE602005021684D1 DE602005021684D1 DE602005021684T DE602005021684T DE602005021684D1 DE 602005021684 D1 DE602005021684 D1 DE 602005021684D1 DE 602005021684 T DE602005021684 T DE 602005021684T DE 602005021684 T DE602005021684 T DE 602005021684T DE 602005021684 D1 DE602005021684 D1 DE 602005021684D1
- Authority
- DE
- Germany
- Prior art keywords
- pimecrolimus
- preparation
- macrolides
- tacrolimus
- crystallization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63237204P | 2004-12-01 | 2004-12-01 | |
| US63392604P | 2004-12-06 | 2004-12-06 | |
| US64169705P | 2005-01-05 | 2005-01-05 | |
| US64186905P | 2005-01-05 | 2005-01-05 | |
| US64186805P | 2005-01-05 | 2005-01-05 | |
| US66244005P | 2005-03-16 | 2005-03-16 | |
| US70568105P | 2005-08-03 | 2005-08-03 | |
| US70916005P | 2005-08-17 | 2005-08-17 | |
| PCT/US2005/043541 WO2006060614A1 (en) | 2004-12-01 | 2005-12-01 | Methods for preparing pimecrolimus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005021684D1 true DE602005021684D1 (de) | 2010-07-15 |
Family
ID=36097009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005021684T Active DE602005021684D1 (de) | 2004-12-01 | 2005-12-01 | Verfahren zur herstellung von pimecrolimus |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7589100B2 (de) |
| EP (4) | EP1817314A1 (de) |
| JP (4) | JP2007523069A (de) |
| KR (1) | KR20070060144A (de) |
| AT (1) | ATE469908T1 (de) |
| CA (4) | CA2584360A1 (de) |
| DE (1) | DE602005021684D1 (de) |
| IL (4) | IL182869A0 (de) |
| MX (2) | MX2007005221A (de) |
| TW (3) | TW200628483A (de) |
| WO (4) | WO2006060616A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| ES2339682T3 (es) * | 2004-06-01 | 2010-05-24 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procedimiento para la preparacion de la forma amorfa de un farmaco. |
| EP1817314A1 (de) * | 2004-12-01 | 2007-08-15 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Nichthygroskopisches und pulverförmiges amorphes pimecrolimus |
| EP2407471A3 (de) * | 2006-07-25 | 2012-06-20 | Abbott Laboratories | Verfahren zur Herstellung einer kristallinen Form von Rapamycinanalogen |
| US7820812B2 (en) | 2006-07-25 | 2010-10-26 | Abbott Laboratories | Methods of manufacturing crystalline forms of rapamycin analogs |
| US7812032B2 (en) | 2006-07-25 | 2010-10-12 | Abbott Laboratories | Crystalline forms of rapamycin analogs |
| WO2008057511A2 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| CA2678455C (en) | 2007-01-10 | 2019-02-12 | Board Of Regents The University Of Texas System | Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery |
| ES2393639T3 (es) | 2007-01-21 | 2012-12-26 | Hemoteq Ag | Producto médico para tratar cierres de conductos corporales y prevención de nuevos cierres |
| CN101616912A (zh) * | 2007-01-29 | 2009-12-30 | 卫材R&D管理有限公司 | 大环内酯系化合物的固体及其制造方法及其药物组合物 |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| CL2008000374A1 (es) * | 2008-02-05 | 2008-04-04 | Igloo Zone Chile S A | Composicion farmaceutica que comprende un polvo para suspension oral de tacrolimus o una de sus sales, hidratos o solvatos y excipientes farmaceuticamente aceptables; procedimiento de preparacion de dicha composicion farmaceutica; y uso para la preve |
| US20110275798A1 (en) * | 2009-01-21 | 2011-11-10 | Rakesh Bhaiyyaram Mendhe | Method for Determination of Sirolimus Stability and Process for Preparing Its Stable Form |
| IT1394309B1 (it) | 2009-05-22 | 2012-06-06 | Poli Ind Chimica Spa | Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus |
| US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
| JP5933434B2 (ja) | 2009-07-17 | 2016-06-08 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 薬剤送達バルーンの製造方法 |
| WO2011081712A1 (en) * | 2009-12-31 | 2011-07-07 | Boston Scientific Scimed, Inc. | Cryo activated drug delivery and cutting balloons |
| WO2011122573A1 (ja) * | 2010-03-29 | 2011-10-06 | ダイキン工業株式会社 | ３－クロロ－ペンタフルオロプロペンの製造方法 |
| WO2012011877A2 (en) | 2010-07-23 | 2012-01-26 | Curiox Biosystems Pte Ltd | Apparatus and method for multiple reactions in small volumes |
| US9321782B2 (en) | 2010-08-04 | 2016-04-26 | Meril Life Sciences Pvt. Ltd. | Process for preparation of novel 42-O-(heteroalkoxyalkyl) rapamicin compounds with anti-proliferative properties |
| EP2611476B1 (de) | 2010-09-02 | 2016-08-10 | Boston Scientific Scimed, Inc. | Beschichtungsverfahren für wirkstofffreisetzungsballons mit wärmeinduziertem rewrap-gedächtnis |
| US9327264B2 (en) * | 2011-01-31 | 2016-05-03 | Uchicago Argonne, Llc | Containerless synthesis of amorphous and nanophase organic materials |
| WO2013022458A1 (en) | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| EP2972258B1 (de) | 2013-03-15 | 2021-08-04 | Biosensors International Group, Ltd. | Reinigung von rapamycinderivaten |
| AR099354A1 (es) | 2013-11-15 | 2016-07-20 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos |
| US20170072058A1 (en) | 2014-11-21 | 2017-03-16 | Solipharma Llc | Pharmaceutical composition containing tacrolimus and preparation methods thereof |
| CA2998651C (en) * | 2015-11-28 | 2021-01-19 | Biopreme Medical Technologies Inc. | Negative pressure injection device |
| EP3178824A1 (de) | 2015-12-08 | 2017-06-14 | Medichem, S.A. | Verfahren zur herstellung von pimecrolimus |
| KR102592374B1 (ko) | 2017-05-01 | 2023-10-25 | 메다 파마 게엠베하 운트 코. 카게 | 조질의 아스코마이신을 정제된 피메크롤리무스로 전환하는 방법 |
| CN108948046B (zh) * | 2017-05-20 | 2020-11-10 | 鲁南制药集团股份有限公司 | 一种替西罗莫司的中间体及其制备方法 |
| CN110540567A (zh) | 2018-05-28 | 2019-12-06 | 浙江海正药业股份有限公司 | 一种天维菌素b的晶型及其制备方法和用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3244592A (en) * | 1962-06-09 | 1966-04-05 | Arai Tadashi | Ascomycin and process for its production |
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| RU2066324C1 (ru) * | 1987-07-09 | 1996-09-10 | Пфайзер Инк. | Кристаллический дигидрат азитромицина и способ его получения |
| EP0323865A1 (de) | 1988-01-07 | 1989-07-12 | Merck & Co. Inc. | Immunopressantes Mittel |
| DE68925080T2 (de) * | 1988-08-01 | 1996-05-15 | Fujisawa Pharmaceutical Co | FR-901154- und FR-901155-Derivate, Verfahren zu ihrer Herstellung |
| AU640963B2 (en) | 1989-11-09 | 1993-09-09 | MEDA Pharma S.a.r.l | Heteroatoms-containing tricyclic compounds |
| EP0480623A1 (de) | 1990-10-11 | 1992-04-15 | Merck & Co. Inc. | Halomakrolide und Derivate mit immunosuppressiver Wirkung |
| CA2103453A1 (en) | 1991-09-05 | 1993-03-06 | Jay R. Luly | Macrocyclic immunomodulators |
| DK0629209T3 (da) * | 1992-03-02 | 1997-10-13 | Pfizer | Sukkerderivater af makrolider |
| US5359060A (en) * | 1993-07-06 | 1994-10-25 | Pfizer, Inc. | Phosponated derivatives of macrolides |
| UA41884C2 (uk) * | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
| GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| ATE464900T1 (de) * | 1998-03-26 | 2010-05-15 | Astellas Pharma Inc | Retardpräparat mit makroliden wie tacrolimus |
| GB9904930D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Thiazoloindolinone compounds |
| CZ300783B6 (cs) * | 1999-05-25 | 2009-08-12 | Astellas Pharma Inc. | Zpusob oddelování sloucenin |
| TW553946B (en) * | 1999-09-08 | 2003-09-21 | Fujisawa Pharmaceutical Co | Method for separating lactone-containing high-molecular weight compounds |
| ES2177373B1 (es) | 1999-11-26 | 2003-11-01 | Astur Pharma Sa | Preparacion de azitromicina en su forma no cristalina |
| GB0012383D0 (en) | 2000-05-22 | 2000-07-12 | Novartis Ag | Organic compounds |
| PT1469833T (pt) | 2002-02-01 | 2021-07-13 | Bend Res Inc | Método para produzir dispersões de fármaco amorfo sólido seco por pulverização homogéneas utilizando aparelho de secagem por pulverização modificado |
| BR0307515A (pt) | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressão |
| JP4261365B2 (ja) * | 2002-02-13 | 2009-04-30 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | 生物学的物質からのマクロライドの抽出方法 |
| JP4298212B2 (ja) * | 2002-03-29 | 2009-07-15 | 大日本印刷株式会社 | 塩酸エピナスチン高融点型結晶の製造法 |
| US7232486B2 (en) * | 2003-03-31 | 2007-06-19 | TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság | Crystallization and purification of macrolides |
| DK1558622T3 (da) * | 2003-07-24 | 2008-02-25 | Teva Gyogyszergyar Zartkoeruee | Fremgangsmåde til oprensning af macrolider |
| WO2005019226A1 (en) | 2003-08-26 | 2005-03-03 | Biocon Limited | A process for the recovery of substantially pure tricyclic macrolide |
| ES2339682T3 (es) | 2004-06-01 | 2010-05-24 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procedimiento para la preparacion de la forma amorfa de un farmaco. |
| CN101031654A (zh) * | 2004-09-10 | 2007-09-05 | 伊瓦克斯制药有限公司 | 结晶他克莫司的分离方法 |
| EP1786915A1 (de) | 2004-09-10 | 2007-05-23 | Ivax Pharmaceuticals S.R.O. | Verfahren zur isolierung von kristallinem tacrolimus |
| GT200500282A (es) * | 2004-10-12 | 2006-05-04 | Heteroatomos conteniendo compuestos triciclicos. | |
| EP1817314A1 (de) * | 2004-12-01 | 2007-08-15 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Nichthygroskopisches und pulverförmiges amorphes pimecrolimus |
-
2005
- 2005-12-01 EP EP05826343A patent/EP1817314A1/de not_active Withdrawn
- 2005-12-01 KR KR1020077010037A patent/KR20070060144A/ko not_active Application Discontinuation
- 2005-12-01 DE DE602005021684T patent/DE602005021684D1/de active Active
- 2005-12-01 EP EP05848588A patent/EP1817316A1/de not_active Withdrawn
- 2005-12-01 WO PCT/US2005/043543 patent/WO2006060616A1/en active Application Filing
- 2005-12-01 TW TW094142326A patent/TW200628483A/zh unknown
- 2005-12-01 TW TW094142291A patent/TW200631955A/zh unknown
- 2005-12-01 CA CA002584360A patent/CA2584360A1/en not_active Abandoned
- 2005-12-01 AT AT05848723T patent/ATE469908T1/de not_active IP Right Cessation
- 2005-12-01 WO PCT/US2005/043544 patent/WO2006060617A1/en active Application Filing
- 2005-12-01 MX MX2007005221A patent/MX2007005221A/es unknown
- 2005-12-01 CA CA002584430A patent/CA2584430A1/en not_active Abandoned
- 2005-12-01 CA CA002584358A patent/CA2584358A1/en not_active Abandoned
- 2005-12-01 JP JP2006551653A patent/JP2007523069A/ja active Pending
- 2005-12-01 JP JP2006551652A patent/JP2007519757A/ja active Pending
- 2005-12-01 CA CA002584365A patent/CA2584365A1/en not_active Abandoned
- 2005-12-01 EP EP05848573A patent/EP1817315A1/de not_active Withdrawn
- 2005-12-01 US US11/293,283 patent/US7589100B2/en not_active Expired - Fee Related
- 2005-12-01 MX MX2007005222A patent/MX2007005222A/es unknown
- 2005-12-01 EP EP05848723A patent/EP1817317B1/de active Active
- 2005-12-01 US US11/293,286 patent/US7439252B2/en not_active Expired - Fee Related
- 2005-12-01 WO PCT/US2005/043541 patent/WO2006060614A1/en active Application Filing
- 2005-12-01 US US11/293,353 patent/US7279571B2/en not_active Expired - Fee Related
- 2005-12-01 WO PCT/US2005/043542 patent/WO2006060615A1/en active Application Filing
- 2005-12-01 TW TW094142290A patent/TWI315310B/zh not_active IP Right Cessation
- 2005-12-01 US US11/293,747 patent/US7645876B2/en not_active Expired - Fee Related
- 2005-12-01 JP JP2006551654A patent/JP2007519758A/ja active Pending
- 2005-12-01 JP JP2006551655A patent/JP2007523896A/ja active Pending
-
2007
- 2007-04-30 IL IL182869A patent/IL182869A0/en unknown
- 2007-04-30 IL IL182872A patent/IL182872A0/en unknown
- 2007-04-30 IL IL182870A patent/IL182870A0/en unknown
- 2007-04-30 IL IL182871A patent/IL182871A0/en unknown
- 2007-07-24 US US11/881,033 patent/US20070270451A1/en not_active Abandoned
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