PE20091024A1 - Anticuerpos monoclonales que se unen a anexelekto y sus usos - Google Patents
Anticuerpos monoclonales que se unen a anexelekto y sus usosInfo
- Publication number
- PE20091024A1 PE20091024A1 PE2008001927A PE2008001927A PE20091024A1 PE 20091024 A1 PE20091024 A1 PE 20091024A1 PE 2008001927 A PE2008001927 A PE 2008001927A PE 2008001927 A PE2008001927 A PE 2008001927A PE 20091024 A1 PE20091024 A1 PE 20091024A1
- Authority
- PE
- Peru
- Prior art keywords
- anexelekto
- monoclonal antibodies
- antibodies binding
- axl
- cdr2
- Prior art date
Links
- 208000009641 Frontonasal dysplasia Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000005907 cancer growth Effects 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
REFERIDO A UN ANTICUERPO MONOCLONAL QUIMERICO O HUMANIZADO, QUE SE UNE A FND1 DE AXL, QUE COMPRENDE CADENAS PESADAS CDR1, CDR2 Y CDR3 DE SEQ ID Nº 4, 5 Y 6 RESPECTIVAMENTE Y CADENAS LIVIANAS CDR1, CDR2 Y CDR3 DE SEQ ID Nº 8, 9 Y 10 RESPECTIVAMENTE, AMBAS CON SUSTITUCION, SUPRESION, INSERCION Y/O ADICION DE UNO O MAS AMINOACIDOS. DICHO ANTICUERPO INHIBE LA ANGIOGENESIS, SUPRIME EL CRECIMIENTO DE CELULAS CANCEROSAS, INDUCEN E INHIBEN LA FOSFORILACION DE AXL Y ES ANTICANCERIGENO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007297168 | 2007-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091024A1 true PE20091024A1 (es) | 2009-08-12 |
Family
ID=40638811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001927A PE20091024A1 (es) | 2007-11-15 | 2008-11-14 | Anticuerpos monoclonales que se unen a anexelekto y sus usos |
Country Status (18)
Country | Link |
---|---|
US (2) | US9175091B2 (es) |
EP (2) | EP2853544A1 (es) |
JP (2) | JP5554993B2 (es) |
KR (1) | KR101568051B1 (es) |
CN (1) | CN101918452A (es) |
AR (1) | AR069333A1 (es) |
AU (1) | AU2008321835B2 (es) |
BR (1) | BRPI0820543A2 (es) |
CA (1) | CA2706549A1 (es) |
CL (1) | CL2008003416A1 (es) |
IL (1) | IL205545A0 (es) |
MX (1) | MX2010005397A (es) |
PE (1) | PE20091024A1 (es) |
RU (1) | RU2559530C2 (es) |
SG (1) | SG188134A1 (es) |
TW (1) | TW200936160A (es) |
WO (1) | WO2009063965A1 (es) |
ZA (1) | ZA201003496B (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
HUE029635T2 (en) | 2007-09-26 | 2017-03-28 | Chugai Pharmaceutical Co Ltd | A method for modifying an isoelectric point of an antibody by amino acid substitution in CDR |
SG193868A1 (en) | 2007-09-26 | 2013-10-30 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
JP5554993B2 (ja) | 2007-11-15 | 2014-07-23 | 中外製薬株式会社 | Anexelektoに結合するモノクローナル抗体、およびその利用 |
DK2708559T3 (en) | 2008-04-11 | 2018-06-14 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of repeatedly binding two or more antigen molecules |
TWI682995B (zh) | 2009-03-19 | 2020-01-21 | 日商中外製藥股份有限公司 | 抗體恆定區域改變體 |
JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
MA33405B1 (fr) | 2009-05-15 | 2012-07-03 | Chugai Pharmaceutical Co Ltd | Anticorps anti-axl |
TW201106972A (en) | 2009-07-27 | 2011-03-01 | Genentech Inc | Combination treatments |
RU2577986C2 (ru) | 2010-06-18 | 2016-03-20 | Дженентек, Инк. | Антитела против axl и способы их применения |
TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
JP6120833B2 (ja) * | 2011-06-22 | 2017-04-26 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル)Inserm(Institut National Dela Sante Et De La Recherche Medicale) | 抗Axl抗体及びその使用 |
US9249228B2 (en) | 2011-06-22 | 2016-02-02 | Oribase Pharma | Anti-Axl antibodies and uses thereof |
EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
US20150252370A1 (en) * | 2014-03-04 | 2015-09-10 | Academia Sinica | Use of atx inhibitors for treatment or prevention of influenza virus a infections |
GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
GB201410825D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
IL296633A (en) | 2014-07-11 | 2022-11-01 | Genmab As | Antibodies that bind axl |
DK3186284T3 (da) | 2014-08-28 | 2022-05-09 | Bioatla Inc | Betinget aktive kimæriske antigenreceptorer til modificerede t-celler |
WO2016091891A1 (en) | 2014-12-09 | 2016-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against axl |
AU2015366213B2 (en) | 2014-12-18 | 2021-10-07 | Bergenbio Asa | Anti-Axl antagonistic antibodies |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
ME03772B (me) | 2015-07-10 | 2021-04-20 | Genmab As | Konjugati antitijela specifičnog za axl i lijeka za liječenje kancera |
CN108291669B (zh) * | 2015-12-03 | 2019-10-11 | 三菱电机株式会社 | 封闭用弹性体、空调装置及封闭方法 |
EP3402465B1 (en) | 2016-01-13 | 2024-03-13 | Genmab A/S | Formulation for antibody and drug conjugate thereof |
TWI844509B (zh) | 2016-05-13 | 2024-06-11 | 美商拜奧亞特拉公司 | 抗-ror2抗體、抗體片段、其免疫結合物及其用途 |
GB201610902D0 (en) | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
JP7280827B2 (ja) | 2017-01-18 | 2023-05-24 | エクスマ バイオテック コーポレイション | Axlまたはror2に対するキメラ抗原受容体およびその使用方法 |
BR112019021880A2 (pt) | 2017-04-20 | 2020-06-02 | Adc Therapeutics Sa | Terapia de combinação com conjugado anticorpo anti-axl-droga |
CN112218895A (zh) | 2018-04-10 | 2021-01-12 | 健玛保 | 用于癌症治疗的axl特异性抗体 |
CN110540592B (zh) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | 结合axl蛋白的抗体及其应用 |
US20220273809A1 (en) | 2019-07-19 | 2022-09-01 | Genmab A/S | Axl antibody-drug conjugates for use in treating cancer |
GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
CN110982791A (zh) * | 2019-12-26 | 2020-04-10 | 百泰生物药业有限公司 | 一种分泌axl抗体的杂交瘤细胞的制备筛选方法 |
AR121441A1 (es) | 2020-02-28 | 2022-06-08 | Symphogen As | Anticuerpos anti-axl y composiciones |
GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
WO2021204713A1 (en) | 2020-04-08 | 2021-10-14 | Bergenbio Asa | Axl inhibitors for antiviral therapy |
GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
CN116063535B (zh) * | 2022-09-14 | 2023-09-26 | 北京市疾病预防控制中心 | 一种抗体或其抗原结合片段及其制备方法和应用 |
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EP1922310A2 (en) | 2005-09-07 | 2008-05-21 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
EP1789435B1 (en) * | 2005-09-12 | 2010-02-24 | Industry Foundation of Chonnam National University | A method for production of mature natural killer cell |
US7498142B2 (en) * | 2006-01-31 | 2009-03-03 | Yeda Research And Development Co., Ltd. | Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies |
CA2641026A1 (en) * | 2006-02-01 | 2007-08-09 | The Johns Hopkins University | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
WO2008098139A2 (en) | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
HUE029635T2 (en) | 2007-09-26 | 2017-03-28 | Chugai Pharmaceutical Co Ltd | A method for modifying an isoelectric point of an antibody by amino acid substitution in CDR |
CN101939336B (zh) | 2007-11-12 | 2014-05-14 | U3制药有限公司 | Axl抗体 |
JP5554993B2 (ja) | 2007-11-15 | 2014-07-23 | 中外製薬株式会社 | Anexelektoに結合するモノクローナル抗体、およびその利用 |
MA33405B1 (fr) | 2009-05-15 | 2012-07-03 | Chugai Pharmaceutical Co Ltd | Anticorps anti-axl |
-
2008
- 2008-11-14 JP JP2009541179A patent/JP5554993B2/ja not_active Expired - Fee Related
- 2008-11-14 WO PCT/JP2008/070739 patent/WO2009063965A1/ja active Application Filing
- 2008-11-14 PE PE2008001927A patent/PE20091024A1/es not_active Application Discontinuation
- 2008-11-14 AU AU2008321835A patent/AU2008321835B2/en not_active Ceased
- 2008-11-14 MX MX2010005397A patent/MX2010005397A/es active IP Right Grant
- 2008-11-14 RU RU2010123916/10A patent/RU2559530C2/ru not_active IP Right Cessation
- 2008-11-14 US US12/742,947 patent/US9175091B2/en not_active Expired - Fee Related
- 2008-11-14 KR KR1020107012876A patent/KR101568051B1/ko not_active IP Right Cessation
- 2008-11-14 SG SG2013010061A patent/SG188134A1/en unknown
- 2008-11-14 TW TW097144034A patent/TW200936160A/zh unknown
- 2008-11-14 EP EP14177416.6A patent/EP2853544A1/en not_active Withdrawn
- 2008-11-14 EP EP08848865A patent/EP2228392A4/en not_active Withdrawn
- 2008-11-14 CA CA2706549A patent/CA2706549A1/en not_active Abandoned
- 2008-11-14 CN CN2008801252159A patent/CN101918452A/zh active Pending
- 2008-11-14 BR BRPI0820543-4A patent/BRPI0820543A2/pt not_active IP Right Cessation
- 2008-11-14 AR ARP080104986A patent/AR069333A1/es unknown
- 2008-11-17 CL CL2008003416A patent/CL2008003416A1/es unknown
-
2010
- 2010-05-05 IL IL205545A patent/IL205545A0/en unknown
- 2010-05-18 ZA ZA2010/03496A patent/ZA201003496B/en unknown
-
2014
- 2014-05-30 JP JP2014111976A patent/JP2014224116A/ja not_active Ceased
-
2015
- 2015-09-09 US US14/848,825 patent/US20160053019A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2706549A1 (en) | 2009-05-22 |
ZA201003496B (en) | 2011-08-31 |
BRPI0820543A2 (pt) | 2015-06-16 |
AR069333A1 (es) | 2010-01-13 |
AU2008321835A1 (en) | 2009-05-22 |
SG188134A1 (en) | 2013-03-28 |
JPWO2009063965A1 (ja) | 2011-03-31 |
KR101568051B1 (ko) | 2015-11-10 |
JP2014224116A (ja) | 2014-12-04 |
EP2228392A1 (en) | 2010-09-15 |
RU2559530C2 (ru) | 2015-08-10 |
WO2009063965A1 (ja) | 2009-05-22 |
US20160053019A1 (en) | 2016-02-25 |
CN101918452A (zh) | 2010-12-15 |
US9175091B2 (en) | 2015-11-03 |
US20110044984A1 (en) | 2011-02-24 |
MX2010005397A (es) | 2010-10-04 |
CL2008003416A1 (es) | 2009-10-30 |
EP2853544A1 (en) | 2015-04-01 |
JP5554993B2 (ja) | 2014-07-23 |
RU2010123916A (ru) | 2011-12-20 |
AU2008321835B2 (en) | 2014-11-20 |
TW200936160A (en) | 2009-09-01 |
IL205545A0 (en) | 2010-12-30 |
EP2228392A4 (en) | 2012-05-02 |
KR20100097688A (ko) | 2010-09-03 |
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