EA201692287A1 - Антигенсвязывающая молекула, перенаправляющая т-клетки на клетки, обладающие иммуносупрессорной функцией - Google Patents

Антигенсвязывающая молекула, перенаправляющая т-клетки на клетки, обладающие иммуносупрессорной функцией

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EA201692287A1
EA201692287A1 EA201692287A EA201692287A EA201692287A1 EA 201692287 A1 EA201692287 A1 EA 201692287A1 EA 201692287 A EA201692287 A EA 201692287A EA 201692287 A EA201692287 A EA 201692287A EA 201692287 A1 EA201692287 A1 EA 201692287A1
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cells
antigen binding
function
antigensocating
immunosupressor
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EA201692287A
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English (en)
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Томоюки Игава
Такахиро Исигуро
Симон Сакагучи
Хироёси Нисикава
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Чугаи Сеияку Кабушики Каиша
Осака Юниверсити
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Publication of EA201692287A1 publication Critical patent/EA201692287A1/ru

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Abstract

В заявке описана антигенсвязывающая молекула, которая обладает очень высоким противораковым действием, превышающим активность общепринятых антигенсвязывающих молекул, в результате того, что антигенсвязывающая молекула перекрестно сшивает Т-клетки и клетки, обладающие подавляющей иммунный ответ функцией, и индуцирует повреждение клеток, обладающих подавляющей иммунный ответ функцией. Антигенсвязывающая молекула включает (I) домен, который связывается с молекулами, экспрессируемыми на поверхности клеток, которые обладают подавляющей иммунный ответ функцией; и (II) домен, который связывается с комплексом Т-клеточного рецептора.
EA201692287A 2014-05-13 2015-05-13 Антигенсвязывающая молекула, перенаправляющая т-клетки на клетки, обладающие иммуносупрессорной функцией EA201692287A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014099707 2014-05-13
PCT/JP2015/063716 WO2015174439A1 (ja) 2014-05-13 2015-05-13 免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子

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EA201692287A1 true EA201692287A1 (ru) 2017-06-30

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US (1) US11505605B2 (ru)
EP (1) EP3144388B1 (ru)
JP (1) JP6894702B2 (ru)
KR (1) KR20170017916A (ru)
CN (1) CN106459954A (ru)
AU (1) AU2015260230A1 (ru)
BR (1) BR112016026299A2 (ru)
CA (1) CA2947157A1 (ru)
EA (1) EA201692287A1 (ru)
IL (1) IL248398A0 (ru)
MX (1) MX2016014434A (ru)
SG (1) SG11201609370QA (ru)
TW (1) TW201623333A (ru)
WO (1) WO2015174439A1 (ru)

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US11850264B2 (en) 2017-11-20 2023-12-26 University College Cardiff Consultants Ltd. Gamma delta T-cell receptor and its ligand

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