EA201692287A1 - ANTIGENSOCATING MOLECULE, T-CELL FORWARDING ON CELLS WITH IMMUNOSUPRESSOR FUNCTION - Google Patents

ANTIGENSOCATING MOLECULE, T-CELL FORWARDING ON CELLS WITH IMMUNOSUPRESSOR FUNCTION

Info

Publication number
EA201692287A1
EA201692287A1 EA201692287A EA201692287A EA201692287A1 EA 201692287 A1 EA201692287 A1 EA 201692287A1 EA 201692287 A EA201692287 A EA 201692287A EA 201692287 A EA201692287 A EA 201692287A EA 201692287 A1 EA201692287 A1 EA 201692287A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cells
antigen binding
function
antigensocating
immunosupressor
Prior art date
Application number
EA201692287A
Other languages
Russian (ru)
Inventor
Томоюки Игава
Такахиро Исигуро
Симон Сакагучи
Хироёси Нисикава
Original Assignee
Чугаи Сеияку Кабушики Каиша
Осака Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Чугаи Сеияку Кабушики Каиша, Осака Юниверсити filed Critical Чугаи Сеияку Кабушики Каиша
Publication of EA201692287A1 publication Critical patent/EA201692287A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

В заявке описана антигенсвязывающая молекула, которая обладает очень высоким противораковым действием, превышающим активность общепринятых антигенсвязывающих молекул, в результате того, что антигенсвязывающая молекула перекрестно сшивает Т-клетки и клетки, обладающие подавляющей иммунный ответ функцией, и индуцирует повреждение клеток, обладающих подавляющей иммунный ответ функцией. Антигенсвязывающая молекула включает (I) домен, который связывается с молекулами, экспрессируемыми на поверхности клеток, которые обладают подавляющей иммунный ответ функцией; и (II) домен, который связывается с комплексом Т-клеточного рецептора.The application describes an antigen binding molecule that has a very high anti-cancer effect, exceeding the activity of conventional antigen binding molecules, due to the fact that the antigen binding molecule cross-links T-cells and cells that have an inhibitory immune response function and induces damage to cells that have an inhibitory immune response function . The antigen binding molecule comprises (I) a domain that binds to molecules expressed on the surface of cells that have an inhibitory immune response function; and (ii) a domain that binds to the T-cell receptor complex.

EA201692287A 2014-05-13 2015-05-13 ANTIGENSOCATING MOLECULE, T-CELL FORWARDING ON CELLS WITH IMMUNOSUPRESSOR FUNCTION EA201692287A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014099707 2014-05-13
PCT/JP2015/063716 WO2015174439A1 (en) 2014-05-13 2015-05-13 T cell-redirected antigen-binding molecule for cells having immunosuppression function

Publications (1)

Publication Number Publication Date
EA201692287A1 true EA201692287A1 (en) 2017-06-30

Family

ID=54479976

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692287A EA201692287A1 (en) 2014-05-13 2015-05-13 ANTIGENSOCATING MOLECULE, T-CELL FORWARDING ON CELLS WITH IMMUNOSUPRESSOR FUNCTION

Country Status (14)

Country Link
US (1) US11505605B2 (en)
EP (1) EP3144388B1 (en)
JP (1) JP6894702B2 (en)
KR (1) KR20170017916A (en)
CN (1) CN106459954A (en)
AU (1) AU2015260230A1 (en)
BR (1) BR112016026299A2 (en)
CA (1) CA2947157A1 (en)
EA (1) EA201692287A1 (en)
IL (1) IL248398A0 (en)
MX (1) MX2016014434A (en)
SG (1) SG11201609370QA (en)
TW (1) TW201623333A (en)
WO (1) WO2015174439A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850264B2 (en) 2017-11-20 2023-12-26 University College Cardiff Consultants Ltd. Gamma delta T-cell receptor and its ligand

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006106905A1 (en) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
EP2006381B1 (en) 2006-03-31 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Method for controlling blood pharmacokinetics of antibodies
EP4368721A2 (en) 2007-09-26 2024-05-15 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in cdr
BR112013013311A2 (en) 2010-11-30 2017-09-19 Chugai Pharmaceutical Co Ltd cytotoxicity-inducing therapeutic agent
EP3333186B9 (en) 2012-03-28 2023-10-04 Gadeta B.V. Combinatorial gamma 9 delta 2 t cell receptor chain exchange
RU2730594C2 (en) 2013-09-27 2020-08-24 Чугаи Сейяку Кабусики Кайся Method of producing a polypeptide heteromultiters
SG11201607434WA (en) 2014-04-07 2016-10-28 Chugai Pharmaceutical Co Ltd Immunoactivating antigen-binding molecule
WO2015174439A1 (en) 2014-05-13 2015-11-19 中外製薬株式会社 T cell-redirected antigen-binding molecule for cells having immunosuppression function
MA40764A (en) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
CA2975078A1 (en) 2015-01-27 2016-08-04 Lava Therapeutics B.V. Single domain antibodies targeting cd1d
US10336824B2 (en) 2015-03-13 2019-07-02 Cytomx Therapeutics, Inc. Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of thereof
EP3279216A4 (en) 2015-04-01 2019-06-19 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
CA2984794A1 (en) 2015-05-07 2016-11-10 Agenus Inc. Anti-ox40 antibodies and methods of use thereof
MA42447A (en) 2015-07-13 2018-05-23 Cytomx Therapeutics Inc ANTI-PD-1 ANTIBODIES, ACTIVABLE ANTI-PD-1 ANTIBODIES, AND METHODS OF USE THEREOF
US20190255107A1 (en) * 2015-10-09 2019-08-22 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
EP3378487B1 (en) 2015-11-18 2022-03-16 Chugai Seiyaku Kabushiki Kaisha Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
JP6925278B2 (en) 2015-11-18 2021-08-25 中外製薬株式会社 Method of enhancing humoral immune response
IL299072A (en) * 2015-12-02 2023-02-01 Memorial Sloan Kettering Cancer Center Antibodies and methods of use thereof
JP6175590B1 (en) * 2016-03-14 2017-08-02 中外製薬株式会社 Cytotoxicity-inducing therapeutic agent for use in cancer treatment
SG11201807936VA (en) * 2016-03-14 2018-10-30 Chugai Pharmaceutical Co Ltd Cell injury inducing therapeutic drug for use in cancer therapy
KR20230091191A (en) 2016-05-27 2023-06-22 아게누스 인코포레이티드 Anti-tim-3 antibodies and methods of use thereof
CA3027124A1 (en) * 2016-06-10 2017-12-14 Umc Utrecht Holding B.V. Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response
MX2019003683A (en) 2016-10-11 2019-08-22 Agenus Inc Anti-lag-3 antibodies and methods of use thereof.
MA46770A (en) 2016-11-09 2019-09-18 Agenus Inc ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND PROCESSES FOR USE
WO2018120842A1 (en) * 2016-12-30 2018-07-05 上海欣百诺生物科技有限公司 Bifunctional molecule and use thereof
KR102089072B1 (en) * 2017-01-06 2020-03-17 주식회사 유틸렉스 Anti-human 4-1BB antibody and use thereof
TW201834688A (en) 2017-02-24 2018-10-01 日商中外製藥股份有限公司 Pharmaceutical composition, antigen-binding molecules, treatment method, and screening method
EP3596122A1 (en) * 2017-02-28 2020-01-22 Bristol-Myers Squibb Company Use of anti-ctla-4 antibodies with enhanced adcc to enhance immune response to a vaccine
HUE054316T2 (en) * 2017-03-29 2021-08-30 Shionogi & Co Pharmaceutical composition for cancer treatment
RS64576B1 (en) 2017-05-01 2023-10-31 Agenus Inc Anti-tigit antibodies and methods of use thereof
AU2018275209A1 (en) 2017-05-30 2019-10-17 Bristol-Myers Squibb Company Compositions comprising an anti-LAG-3 antibody or an anti-LAG-3 antibody and an anti-PD-1 or anti-PD-L1 antibody
HUE065242T2 (en) 2017-05-30 2024-05-28 Bristol Myers Squibb Co Treatment of lag-3 positive tumors
JP2020522495A (en) 2017-05-30 2020-07-30 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Composition comprising a combination of anti-LAG-3 antibody, PD-1 pathway inhibitor and immunotherapeutic agent
CN107099603A (en) * 2017-05-31 2017-08-29 成都克里斯博生物科技有限公司 Tumour immunity T cell detection kit and detection method
WO2018222949A1 (en) 2017-06-01 2018-12-06 Cytomx Therapeutics, Inc. Activatable anti-pdl1 antibodies, and methods of use thereof
EP3689909A4 (en) 2017-09-29 2021-12-29 Jiangsu Hengrui Medicine Co., Ltd. Tigit antibody, antigen-binding fragment thereof, and medical use thereof
US12065500B2 (en) 2018-05-16 2024-08-20 Janssen Biotech, Inc. Methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics
US20210238287A1 (en) 2018-07-26 2021-08-05 Bristol-Myers Squibb Company LAG-3 Combination Therapy for the Treatment of Cancer
JP7457007B2 (en) 2018-09-19 2024-03-27 ラヴァ・セラピューティクス・エヌ・ヴイ Dual-acting CD1d immunoglobulin
MX2021003903A (en) 2018-10-19 2021-06-04 Bristol Myers Squibb Co Combination therapy for melanoma.
EP3915581A4 (en) * 2019-01-24 2023-03-22 Chugai Seiyaku Kabushiki Kaisha Novel cancer antigens and antibodies of said antigens
EP3976831A1 (en) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Multi-tumor gene signatures for suitability to immuno-oncology therapy
CN114174537A (en) 2019-05-30 2022-03-11 百时美施贵宝公司 Cell localization features and combination therapies
EP3976832A1 (en) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy
EP4023230A4 (en) * 2019-06-05 2023-11-15 Chugai Seiyaku Kabushiki Kaisha Antibody cleavage site-binding molecule
WO2020250940A1 (en) 2019-06-11 2020-12-17 小野薬品工業株式会社 Immunosuppression agent
CR20220049A (en) * 2019-07-10 2022-03-02 Chugai Pharmaceutical Co Ltd Claudin-6 binding molecules and uses thereof
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
MX2022003197A (en) 2019-09-22 2022-04-11 Bristol Myers Squibb Co Quantitative spatial profiling for lag-3 antagonist therapy.
CN113416258B (en) * 2019-10-24 2023-08-29 北京免疫方舟医药科技有限公司 Multispecific antibody and preparation method and application thereof
WO2021092220A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
WO2021092221A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
EP4054723A1 (en) 2019-11-08 2022-09-14 Bristol-Myers Squibb Company Lag-3 antagonist therapy for melanoma
KR20220139915A (en) 2020-02-06 2022-10-17 브리스톨-마이어스 스큅 컴퍼니 IL-10 and its uses
US20240043530A1 (en) 2020-03-13 2024-02-08 Jiangsu Hengrui Pharmaceuticals Co., Ltd. PVRIG Binding Protein And Its Medical Uses
AU2021306613A1 (en) 2020-07-07 2023-02-02 BioNTech SE Therapeutic RNA for HPV-positive cancer
BR112023003427A2 (en) 2020-08-28 2023-03-21 Bristol Myers Squibb Co LAG-3 ANTAGONIST THERAPY FOR HEPATOCELLULAR CARCINOMA
WO2022047412A1 (en) 2020-08-31 2022-03-03 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
IL301907A (en) 2020-10-23 2023-06-01 Bristol Myers Squibb Co Lag-3 antagonist therapy for lung cancer
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
TW202245808A (en) 2020-12-21 2022-12-01 德商拜恩迪克公司 Therapeutic rna for treating cancer
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
EP4267172A1 (en) 2020-12-28 2023-11-01 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
EP4267105A1 (en) 2020-12-28 2023-11-01 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
CA3211501A1 (en) * 2021-02-19 2022-08-25 Janssen Biotech, Inc. Materials and methods for targeting regulatory t cells for enhancing immune surveillance
US20240181052A1 (en) 2021-03-29 2024-06-06 Juno Therapeutics, Inc. Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
AR125753A1 (en) 2021-05-04 2023-08-09 Agenus Inc ANTI-TIGIT ANTIBODIES, ANTI-CD96 ANTIBODIES AND METHODS OF USE OF THESE
WO2022240741A1 (en) 2021-05-12 2022-11-17 Dana-Farber Cancer Institute, Inc. Lag3 and gal3 inhibitory agents, xbp1, cs1, and cd138 peptides, and methods of use thereof
JP2024525758A (en) 2021-07-13 2024-07-12 ビオンテック・ソシエタス・エウロパエア Multispecific binding agents to CD40 and CD137 in combination therapy for cancer - Patents.com
EP4403573A1 (en) 2021-09-15 2024-07-24 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising anti-pvrig/tigit bispecific antibody
KR20240055080A (en) 2021-09-15 2024-04-26 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Proteins that specifically bind to PD-1 and their pharmaceutical uses
WO2023053282A1 (en) 2021-09-29 2023-04-06 中外製薬株式会社 Cytotoxicity-inducing therapeutic agent for use in treatment of cancer
TW202333802A (en) 2021-10-11 2023-09-01 德商拜恩迪克公司 Therapeutic rna for lung cancer
KR20240099362A (en) 2021-10-29 2024-06-28 브리스톨-마이어스 스큅 컴퍼니 LAG-3 antagonist therapy for hematologic malignancies
MX2024008831A (en) 2022-01-26 2024-07-25 Bristol Myers Squibb Co Combination therapy for hepatocellular carcinoma.
CN118765284A (en) 2022-02-25 2024-10-11 百时美施贵宝公司 Combination therapy for colorectal cancer
WO2023168404A1 (en) 2022-03-04 2023-09-07 Bristol-Myers Squibb Company Methods of treating a tumor
WO2023170606A1 (en) 2022-03-08 2023-09-14 Alentis Therapeutics Ag Use of anti-claudin-1 antibodies to increase t cell availability
CN118871451A (en) 2022-03-18 2024-10-29 百时美施贵宝公司 Method for isolating polypeptides
WO2023235847A1 (en) 2022-06-02 2023-12-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
CN115806629A (en) * 2022-08-03 2023-03-17 深圳市先康达生命科学有限公司 Autocrine IL-15 and anti-CTLA4 combined fusion protein and application thereof
WO2024116140A1 (en) 2022-12-01 2024-06-06 Medimmune Limited Combination therapy for treatment of cancer comprising anti-pd-l1 and anti-cd73 antibodies
WO2024126457A1 (en) 2022-12-14 2024-06-20 Astellas Pharma Europe Bv Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
WO2024137776A1 (en) 2022-12-21 2024-06-27 Bristol-Myers Squibb Company Combination therapy for lung cancer
WO2024196952A1 (en) 2023-03-20 2024-09-26 Bristol-Myers Squibb Company Tumor subtype assessment for cancer therapy

Family Cites Families (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121424A (en) 1991-11-25 2000-09-19 Enzon, Inc. Multivalent antigen-binding proteins
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
US5601819A (en) * 1988-08-11 1997-02-11 The General Hospital Corporation Bispecific antibodies for selective immune regulation and for selective immune cell binding
EP0497883B1 (en) 1989-10-27 1998-07-15 Arch Development Corporation Compositions and their use for promoting immunopotentiation
GB9206422D0 (en) 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6805869B2 (en) 1996-06-12 2004-10-19 Shanghai Cp Guojian Pharmaceutical Co., Ltd. Cellular vaccines and immunotherapeutics and methods for their preparation
IL132560A0 (en) 1997-05-02 2001-03-19 Genentech Inc A method for making multispecific antibodies having heteromultimeric and common components
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
AU4009899A (en) 1998-05-23 1999-12-13 Tanox, Inc. Molecules targeting cd40 and tumor cells
DK1100830T3 (en) * 1998-07-28 2004-01-19 Micromet Ag Straight Mini Antibodies
WO2000018806A1 (en) 1998-09-25 2000-04-06 Horst Lindhofer Bispecific and trispecific antibodies which specifically react with inducible surface antigens as operational target structures
US20030035798A1 (en) * 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
EP1141024B1 (en) 1999-01-15 2018-08-08 Genentech, Inc. POLYPEPTIDE COMPRISING A VARIANT HUMAN IgG1 Fc REGION
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
HUP0200484A2 (en) * 1999-03-11 2002-06-29 Micromet Ag Antibody and chemokine constructs that are directed to ccr5, and their use for treating autoimmune diseases
AU784012B2 (en) 1999-08-24 2006-01-12 E. R. Squibb & Sons, L.L.C. Human CTLA-4 antibodies and their uses
AU2001264946A1 (en) 2000-05-24 2001-12-03 Imclone Systems Incorporated Bispecific immunoglobulin-like antigen binding proteins and method of production
DE10034607A1 (en) 2000-07-20 2002-02-07 Gundram Jung Multi-specific reagent for the selective stimulation of cell surface receptors
PL366062A1 (en) 2000-09-08 2005-01-24 Micromet Ag Antibody and/or chemokine constructs and their use in immunological disorders
CN1294148C (en) 2001-04-11 2007-01-10 中国科学院遗传与发育生物学研究所 Single-stranded cyctic trispecific antibody
ATE430580T1 (en) 2001-10-25 2009-05-15 Genentech Inc GLYCOPROTEIN COMPOSITIONS
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
WO2003074679A2 (en) 2002-03-01 2003-09-12 Xencor Antibody optimization
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
JP2006502091A (en) 2002-03-01 2006-01-19 イミューノメディクス、インコーポレイテッド Bispecific antibody point mutations to increase clearance rate
CN1678634A (en) 2002-06-28 2005-10-05 多曼蒂斯有限公司 Immunoglobulin single variable antigen combination area and its opposite constituent
US20060235208A1 (en) 2002-09-27 2006-10-19 Xencor, Inc. Fc variants with optimized properties
MXPA05004022A (en) 2002-10-17 2005-10-05 Genmab As Human monoclonal antibodies against cd20.
EP1591527B1 (en) * 2003-01-23 2015-08-26 Ono Pharmaceutical Co., Ltd. Substance specific to human pd-1
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
CA2766627C (en) 2003-05-02 2019-12-03 Xencor, Inc. Optimized fc variants and methods for their generation
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
WO2005063815A2 (en) 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Fcϝ receptor-binding polypeptide variants and methods related thereto
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
WO2005092927A1 (en) 2004-03-23 2005-10-06 Biogen Idec Ma Inc. Receptor coupling agents and therapeutic uses thereof
GB0409799D0 (en) 2004-04-30 2004-06-09 Isis Innovation Method of generating improved immune response
EA010350B1 (en) * 2004-06-03 2008-08-29 Новиммун С.А. Anti-cd3 antibodies and methods of use thereof
ATE486610T1 (en) 2004-07-09 2010-11-15 Chugai Pharmaceutical Co Ltd ANTI-GLYPICAN-3 ANTIBODIES
DK2213683T3 (en) 2004-08-04 2013-09-02 Mentrik Biotech Llc VARIANT Fc REGIONS
EP1858925A2 (en) 2005-01-12 2007-11-28 Xencor, Inc. Antibodies and fc fusion proteins with altered immunogenicity
EP1871808A2 (en) 2005-03-31 2008-01-02 Xencor, Inc. Fc VARIANTS WITH OPTIMIZED PROPERTIES
WO2006106905A1 (en) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
EP1820513A1 (en) 2006-02-15 2007-08-22 Trion Pharma Gmbh Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
PL1999154T3 (en) 2006-03-24 2013-03-29 Merck Patent Gmbh Engineered heterodimeric protein domains
EP2006381B1 (en) 2006-03-31 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Method for controlling blood pharmacokinetics of antibodies
US20090258001A1 (en) 2006-06-06 2009-10-15 Paul Ponath Administration of anti-CD3 antibodies in the treatment of autoimmune diseases
WO2007147901A1 (en) 2006-06-22 2007-12-27 Novo Nordisk A/S Production of bispecific antibodies
EP2049151A4 (en) * 2006-07-17 2010-03-24 Quintessence Biosciences Inc Methods and compositions for the treatment of cancer
GB0620894D0 (en) 2006-10-20 2006-11-29 Univ Southampton Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
JPWO2008090960A1 (en) 2007-01-24 2010-05-20 協和発酵キリン株式会社 Recombinant antibody composition that specifically binds to ganglioside GM2
ES2593484T3 (en) 2007-03-29 2016-12-09 Genmab A/S Bispecific antibodies and their production methods
BRPI0813966A8 (en) 2007-06-29 2016-02-10 Schering Corp USES OF CDM-1
US9688762B2 (en) 2007-09-26 2017-06-27 Chugai Sciyaku Kabushiki Kaisha Modified antibody constant region
WO2009053368A1 (en) 2007-10-22 2009-04-30 Merck Serono S.A. Single ifn-beta fused to a mutated igg fc fragment
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
AU2009204501B2 (en) 2008-01-07 2015-02-12 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
EP3153526B1 (en) * 2008-01-31 2020-09-23 INSERM - Institut National de la Santé et de la Recherche Médicale Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity
EP2240204A1 (en) 2008-02-04 2010-10-20 Medarex, Inc. Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof
WO2009120922A2 (en) 2008-03-27 2009-10-01 Zymogenetics, Inc. Compositions and methods for inhibiting pdgfrbeta and vegf-a
AU2009234253C1 (en) 2008-04-11 2015-05-07 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
BRPI0910482A2 (en) 2008-04-29 2019-09-24 Abbott Lab double variable domain immunoglobins and their uses
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
WO2010034441A1 (en) 2008-09-26 2010-04-01 F. Hoffmann-La Roche Ag Bispecific anti-egfr/anti-igf-1r antibodies
EP2337795A2 (en) 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
BRPI0919840B1 (en) * 2008-10-01 2023-02-28 Amgen Research (Munich) Gmbh BISPECIFIC SINGLE CHAIN ANTIBODY MOLECULE, ITS USE, AND PHARMACEUTICAL COMPOSITION COMPRISING IT
US8927694B2 (en) 2008-11-18 2015-01-06 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
DE202008016028U1 (en) 2008-12-04 2010-04-15 Melitta Haushaltsprodukte Gmbh & Co. Kg Containers for storing objects
JP2012515556A (en) 2009-01-23 2012-07-12 バイオジェン・アイデック・エムエイ・インコーポレイテッド Stabilized Fc polypeptides with reduced effector function and methods of use
ES2738700T3 (en) 2009-02-13 2020-01-24 Immunomedics Inc Immunoconjugates with an intracellularly cleavable link
PE20160653A1 (en) 2009-03-05 2016-07-24 Abbvie Inc IL-17 BINDING PROTEINS
EP2409991B1 (en) 2009-03-19 2017-05-03 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
CN102471380B (en) 2009-04-01 2015-01-14 霍夫曼-拉罗奇有限公司 Anti-fcrh5 antibodies and immunoconjugates and methods of use
AU2010245011B2 (en) 2009-04-27 2015-09-03 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
BRPI1007602A2 (en) 2009-05-27 2016-02-16 Hoffmann La Roche "tri or tetraspecific antibody, method for preparing a trispecific or tetraspecific antibody, host cell, composition, pharmaceutical composition and method for treating a patient in need of therapy"
EP2445936A1 (en) 2009-06-26 2012-05-02 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format
SI2483310T1 (en) 2009-09-29 2014-12-31 Roche Glycart Ag Bispecific death receptor agonistic antibodies
CA2778334A1 (en) 2009-10-20 2011-04-28 Charlotte Mckee Anti-cd3 antibody dosing in autoimmune disease
US10053513B2 (en) 2009-11-30 2018-08-21 Janssen Biotech, Inc. Antibody Fc mutants with ablated effector functions
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
TWI653333B (en) * 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 Cross-species specific PSMAxCD3 bispecific single chain antibody
DK2560993T3 (en) 2010-04-20 2024-10-14 Genmab As HETERODIMERIC ANTIBODY FC-CONTAINING PROTEINS AND METHODS FOR PRODUCTION THEREOF
EP2560683B2 (en) 2010-04-23 2022-07-20 F. Hoffmann-La Roche AG Production of heteromultimeric proteins
EP2569337A1 (en) 2010-05-14 2013-03-20 Rinat Neuroscience Corp. Heterodimeric proteins and methods for producing and purifying them
WO2011147986A1 (en) 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
EP2425997B1 (en) 2010-09-01 2013-04-24 Inalfa Roof Systems Group B.V. Roof assembly for a vehicle
RS59589B1 (en) 2010-11-05 2019-12-31 Zymeworks Inc Stable heterodimeric antibody design with mutations in the fc domain
BR112013013311A2 (en) 2010-11-30 2017-09-19 Chugai Pharmaceutical Co Ltd cytotoxicity-inducing therapeutic agent
US20130295091A1 (en) 2011-01-10 2013-11-07 University Of Zurich Combination therapy including tumor associated antigen binding antibodies
WO2012109624A2 (en) 2011-02-11 2012-08-16 Zyngenia, Inc. Monovalent and multivalent multispecific complexes and uses thereof
WO2012133782A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
KR20200103845A (en) 2011-02-25 2020-09-02 추가이 세이야쿠 가부시키가이샤 FcγRIIb-specific Fc antibody
EP3536708A1 (en) 2011-04-19 2019-09-11 Pfizer Inc Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
EP2537864B1 (en) 2011-06-24 2019-08-07 Laboratoire Français du Fractionnement et des Biotechnologies Fc variants with reduced effector functions
RS57996B1 (en) * 2011-06-30 2019-01-31 Genzyme Corp Inhibitors of t-cell activation
LT2748201T (en) * 2011-08-23 2018-02-26 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
LT2748202T (en) 2011-08-23 2018-09-25 Roche Glycart Ag Bispecific antigen binding molecules
CN109134658B (en) 2011-10-31 2022-10-14 中外制药株式会社 Antigen binding molecules that control association of heavy and light chains
US20140322216A1 (en) 2011-11-08 2014-10-30 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
JP6317674B2 (en) 2011-11-17 2018-04-25 グンドラム・ユング Bispecific antibodies for medical use
BR112014015018A2 (en) 2011-12-19 2020-10-27 Synimmune Gmbh bispecific antibody molecules and their method of production, as well as pharmaceutical composition and nucleic acid molecule
CN104736174B (en) 2012-07-06 2019-06-14 根马布私人有限公司 Protein dimer with triple mutant
WO2014028560A2 (en) 2012-08-14 2014-02-20 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
JOP20200236A1 (en) * 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
PT2925350T (en) 2012-12-03 2019-03-25 Bristol Myers Squibb Co Enhancing anti-cancer activity of immunomodulatory fc fusion proteins
WO2014116846A2 (en) * 2013-01-23 2014-07-31 Abbvie, Inc. Methods and compositions for modulating an immune response
JP6420776B2 (en) * 2013-03-05 2018-11-07 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ Engager cells for immunotherapy
CA3093606A1 (en) 2013-03-15 2014-09-18 Xencor, Inc. Heterodimeric proteins for induction of t cells
US20140302037A1 (en) * 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
WO2014165818A2 (en) 2013-04-05 2014-10-09 T Cell Therapeutics, Inc. Compositions and methods for preventing and treating prostate cancer
EP3016681B1 (en) 2013-07-05 2019-12-18 Genmab A/S Humanized or chimeric cd3 antibodies
RU2730594C2 (en) 2013-09-27 2020-08-24 Чугаи Сейяку Кабусики Кайся Method of producing a polypeptide heteromultiters
AU2014343636A1 (en) 2013-11-04 2016-06-02 Glenmark Pharmaceuticals S.A. Production of T cell retargeting hetero-dimeric immunoglobulins
RS60453B1 (en) 2013-12-17 2020-07-31 Genentech Inc Anti-cd3 antibodies and methods of use
CA2936244A1 (en) 2014-01-21 2015-07-30 Medimmune, Llc Compositions and methods for modulating and redirecting immune responses
AU2015220762B2 (en) 2014-02-21 2019-05-02 Cellectis Method for in situ inhibition of regulatory T cells
WO2015149077A1 (en) * 2014-03-28 2015-10-01 Xencor, Inc. Bispecific antibodies that bind to cd38 and cd3
SG11201607434WA (en) 2014-04-07 2016-10-28 Chugai Pharmaceutical Co Ltd Immunoactivating antigen-binding molecule
WO2015174439A1 (en) 2014-05-13 2015-11-19 中外製薬株式会社 T cell-redirected antigen-binding molecule for cells having immunosuppression function
MA40764A (en) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
EP3305322A4 (en) 2015-06-05 2018-12-26 Chugai Seiyaku Kabushiki Kaisha Combined use of immune activators
WO2017010423A1 (en) 2015-07-10 2017-01-19 中外製薬株式会社 Non-human animal having human cd3 gene substituted for endogenous cd3 gene
JP6925278B2 (en) 2015-11-18 2021-08-25 中外製薬株式会社 Method of enhancing humoral immune response
EP3378487B1 (en) 2015-11-18 2022-03-16 Chugai Seiyaku Kabushiki Kaisha Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
SG11201807936VA (en) 2016-03-14 2018-10-30 Chugai Pharmaceutical Co Ltd Cell injury inducing therapeutic drug for use in cancer therapy
EP3619238A4 (en) 2017-05-02 2021-02-24 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
SG11201810270SA (en) 2017-09-29 2019-04-29 Chugai Pharmaceutical Co Ltd Multispecific antigen-binding molecules having blood coagulation factor viii (fviii) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ing
US11667713B2 (en) 2017-12-28 2023-06-06 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
US12065500B2 (en) 2018-05-16 2024-08-20 Janssen Biotech, Inc. Methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics
EP3897851A2 (en) 2018-12-17 2021-10-27 Revitope Limited Twin immune cell engager

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850264B2 (en) 2017-11-20 2023-12-26 University College Cardiff Consultants Ltd. Gamma delta T-cell receptor and its ligand

Also Published As

Publication number Publication date
MX2016014434A (en) 2017-02-23
CA2947157A1 (en) 2015-11-19
SG11201609370QA (en) 2016-12-29
AU2015260230A1 (en) 2016-11-17
IL248398A0 (en) 2016-11-30
BR112016026299A2 (en) 2018-02-20
KR20170017916A (en) 2017-02-15
WO2015174439A1 (en) 2015-11-19
US11505605B2 (en) 2022-11-22
CN106459954A (en) 2017-02-22
EP3144388B1 (en) 2020-07-01
JPWO2015174439A1 (en) 2017-04-20
JP6894702B2 (en) 2021-06-30
US20170260271A1 (en) 2017-09-14
EP3144388A4 (en) 2018-05-02
EP3144388A1 (en) 2017-03-22
TW201623333A (en) 2016-07-01

Similar Documents

Publication Publication Date Title
EA201692287A1 (en) ANTIGENSOCATING MOLECULE, T-CELL FORWARDING ON CELLS WITH IMMUNOSUPRESSOR FUNCTION
EA201791029A1 (en) ANTIBODIES AGAINST INTERLEUKIN-33 AND THEIR APPLICATION
MX2022005202A (en) Anti-pro/latent-myostatin antibodies and uses thereof.
MX2022009463A (en) Antibodies targeting g-protein coupled receptor and methods of use.
EA201691556A1 (en) ANTIBODY MOLECULES FOR TIM-3 AND THEIR APPLICATION
MX2024006565A (en) Anti-pro/latent myostatin antibodies and methods of use thereof.
BR112019012343A2 (en) il-11ra antibodies
EA201791164A1 (en) HETERODIMERIC ANTIBODIES CONNECTING CD3 AND CD38
EA202092435A3 (en) MONOCLONAL ANTIBODIES AGAINST BCMA
EA201790834A1 (en) ANTIBODY MOLECULES TO PD-L1 AND THEIR APPLICATION
EA201691765A1 (en) ANTIBODY MOLECULES AGAINST LAG-3 AND THEIR APPLICATIONS
EA201691991A1 (en) MULTI-SPECIFIC ANTIBODIES
TWD170353S (en) Necklace
EA201791139A1 (en) HETERODIMERNYE ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS
EA201591750A1 (en) ANTIBODIES AGAINST B7-H4 AND IMMUNOCONJUGATES
BR112015032224A2 (en) anti-fcrh5 antibodies
EP3561057A4 (en) Anti-cd3 antibody, and molecule containing said antibody
CL2017000506A1 (en) New anti-mfi2 antibodies and methods of use
EA201700136A1 (en) POLYMER COMPOSITION FOR LAYER ELEMENT LAYER
EP3095796A4 (en) Anti-human probdnf monoclonal antibody, and uses thereof in pains
EA201700142A1 (en) POLYMER COMPOSITION FOR LAYER ELEMENT LAYER
MX2017001895A (en) Novel antibodies directed to fc gamma receptor iib and fc epsilon receptor.
MX2016011748A (en) Humanized antibodies with increased stability.
EP3527589A4 (en) Monoclonal antibody specifically binding to thioredoxin 1, and use thereof
WO2016090163A3 (en) Anti-acetaminophen antibodies and acetaminophen protein adducts