SG11201607434WA - Immunoactivating antigen-binding molecule - Google Patents
Immunoactivating antigen-binding moleculeInfo
- Publication number
- SG11201607434WA SG11201607434WA SG11201607434WA SG11201607434WA SG11201607434WA SG 11201607434W A SG11201607434W A SG 11201607434WA SG 11201607434W A SG11201607434W A SG 11201607434WA SG 11201607434W A SG11201607434W A SG 11201607434WA SG 11201607434W A SG11201607434W A SG 11201607434WA
- Authority
- SG
- Singapore
- Prior art keywords
- immunoactivating
- antigen
- binding molecule
- molecule
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014078457 | 2014-04-07 | ||
JP2014264589 | 2014-12-26 | ||
PCT/JP2015/060794 WO2015156268A1 (en) | 2014-04-07 | 2015-04-07 | Immunoactivating antigen-binding molecule |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201607434WA true SG11201607434WA (en) | 2016-10-28 |
Family
ID=54287844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201607434WA SG11201607434WA (en) | 2014-04-07 | 2015-04-07 | Immunoactivating antigen-binding molecule |
Country Status (17)
Country | Link |
---|---|
US (2) | US11485790B2 (en) |
EP (1) | EP3130606B1 (en) |
JP (2) | JP6629187B2 (en) |
KR (1) | KR102568808B1 (en) |
CN (2) | CN118440206A (en) |
AU (1) | AU2015244814B2 (en) |
BR (1) | BR112016022912A2 (en) |
CA (1) | CA2943943C (en) |
ES (1) | ES2900898T3 (en) |
IL (1) | IL247715B (en) |
MX (1) | MX2016012552A (en) |
MY (1) | MY194892A (en) |
PL (1) | PL3130606T3 (en) |
RU (1) | RU2722788C2 (en) |
SG (1) | SG11201607434WA (en) |
TW (1) | TWI726842B (en) |
WO (1) | WO2015156268A1 (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006106905A1 (en) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
SI2202245T1 (en) | 2007-09-26 | 2016-10-28 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
PL2647707T3 (en) | 2010-11-30 | 2019-02-28 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
EP4310191A3 (en) | 2012-06-14 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing modified fc region |
EP3050896B1 (en) | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
CN113307873A (en) | 2013-11-11 | 2021-08-27 | 中外制药株式会社 | Antigen binding molecules comprising altered antibody variable regions |
ES2900898T3 (en) | 2014-04-07 | 2022-03-18 | Chugai Pharmaceutical Co Ltd | Bispecific immunoactivating antibodies |
CA2947157A1 (en) | 2014-05-13 | 2015-11-19 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
MA40764A (en) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENT INDUCING CYTOTOXICITY |
US11154615B2 (en) | 2014-11-11 | 2021-10-26 | Chugai Seiyaku Kabushiki Kaisha | Library of antigen-binding molecules including modified antibody variable region |
US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
EP4219535A1 (en) * | 2015-05-18 | 2023-08-02 | Pieris Pharmaceuticals GmbH | Anti-cancer fusion polypeptide |
US20180171017A1 (en) * | 2015-06-05 | 2018-06-21 | Chugai Seiyaku Kabushiki Kaisha | Combined use of immune activators |
US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
US11649293B2 (en) | 2015-11-18 | 2023-05-16 | Chugai Seiyaku Kabushiki Kaisha | Method for enhancing humoral immune response |
KR20180116215A (en) * | 2016-03-14 | 2018-10-24 | 추가이 세이야쿠 가부시키가이샤 | Cytotoxicity-inducing therapeutic agent for treating cancer |
MY196747A (en) * | 2016-03-14 | 2023-05-03 | Chugai Pharmaceutical Co Ltd | Cell injury inducing therapeutic drug for use in cancer therapy |
RU2018139339A (en) * | 2016-04-22 | 2020-05-22 | Эллигейтор Биосайенс Аб | NEW SPECIFIC POLYPEPTIDES AGAINST CD137 |
PE20190562A1 (en) | 2016-05-27 | 2019-04-22 | Abbvie Biotherapeutics Inc | BISPECIFIC UNION PROTEINS THAT JOIN AN IMMUNOMODULATORY PROTEIN AND A TUMOR ANTIGEN |
KR102632202B1 (en) | 2016-07-14 | 2024-02-02 | 젠맵 에이/에스 | Multispecific antibodies to CD40 and CD137 |
US20190338040A1 (en) * | 2016-07-20 | 2019-11-07 | Igm Biosciences, Inc. | Multimeric cd137/4-1bb binding molecules and uses thereof |
WO2018017763A1 (en) * | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric cd40 binding molecules and uses thereof |
NZ751956A (en) * | 2016-09-23 | 2022-01-28 | Merus Nv | Binding molecules that modulate a biological activity expressed by a cell |
TWI829628B (en) * | 2016-12-19 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | Combination therapy with targeted 4-1bb (cd137) agonists |
CR20190309A (en) * | 2017-01-03 | 2019-08-21 | Hoffmann La Roche | Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9 |
WO2019008386A1 (en) * | 2017-07-06 | 2019-01-10 | Tusk Therapeutics Ltd | Compounds and methods for tumour-specific cell depletion |
IL272103B1 (en) | 2017-07-20 | 2024-06-01 | Aptevo Res & Development Llc | Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods of treating cancer |
CA3071211A1 (en) | 2017-08-04 | 2019-02-07 | Genmab A/S | Binding agents binding to pd-l1 and cd137 and use thereof |
WO2019036855A1 (en) * | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
KR20200078527A (en) | 2017-11-08 | 2020-07-01 | 쿄와 기린 가부시키가이샤 | Bispecific antibodies that bind CD40 and EpCAM |
CN118667027A (en) * | 2017-11-13 | 2024-09-20 | 克雷森多生物制剂有限公司 | Molecules that bind to CD137 and PSMA |
WO2019109238A1 (en) * | 2017-12-05 | 2019-06-13 | Lyvgen Biopharma Co., Ltd. | Anti-cd137 antibodies and uses thereof |
US11952422B2 (en) | 2017-12-05 | 2024-04-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137 |
WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
EP3753956A4 (en) | 2018-02-14 | 2021-12-22 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule and combination |
GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
MA53742A (en) * | 2018-09-28 | 2022-01-05 | Chugai Pharmaceutical Co Ltd | ANTIGEN-BINDING MOLECULES ABLE TO BIND TO CD3 AND CD137 BUT NOT SIMULTANEOUSLY |
US20220112296A1 (en) * | 2018-09-28 | 2022-04-14 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region |
CN113891728A (en) | 2019-05-15 | 2022-01-04 | 协和麒麟株式会社 | Bispecific antibodies that bind to CD40 and FAP |
US20220220216A1 (en) | 2019-05-15 | 2022-07-14 | Kyowa Kirin Co., Ltd. | Bispecific antibody binding to cd40 and gpc3 |
CR20220008A (en) | 2019-06-10 | 2022-02-11 | Chugai Pharmaceutical Co Ltd | Anti-t cell antigen-binding molecule to be used in combination with cytokine inhibitor |
CN110452294B (en) * | 2019-08-06 | 2020-08-07 | 复旦大学 | Five hinge regions and chimeric antigen receptors and immune cells thereof |
CA3173519A1 (en) | 2020-03-31 | 2021-10-07 | Vishnu Priyanka Reddy CHICHILI | Method for producing multispecific antigen-binding molecules |
US20230147840A1 (en) | 2020-03-31 | 2023-05-11 | Chugai Seiyaku Kabushiki Kaisha | Immune activating multispecific antigen-binding molecules and uses thereof |
EP4126969A4 (en) | 2020-03-31 | 2024-05-29 | Chugai Seiyaku Kabushiki Kaisha | Dll3-targeting multispecific antigen-binding molecules and uses thereof |
TW202214286A (en) | 2020-06-19 | 2022-04-16 | 日商中外製藥股份有限公司 | Anti-t cell antigen-binding molecule for use in combination with angiogenesis inhibitor |
MX2023001120A (en) | 2020-07-31 | 2023-02-22 | Chugai Pharmaceutical Co Ltd | Pharmaceutical composition including cell expressing chimeric receptor. |
AU2022260298A1 (en) * | 2021-04-23 | 2023-11-02 | Shanghai Henlius Biotech, Inc. | Anti-gpc3 antibodies, multispecific antibodies and methods of use |
JPWO2023053282A1 (en) | 2021-09-29 | 2023-04-06 | ||
WO2024085166A1 (en) * | 2022-10-19 | 2024-04-25 | アステラス製薬株式会社 | Use of anti-cldn4-anti-cd137 bispecific antibody combined with pd-1 signal inhibitor for cancer treatment |
Family Cites Families (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3883899T3 (en) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | CHANGED ANTIBODIES. |
US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
WO1991006319A1 (en) | 1989-10-27 | 1991-05-16 | Arch Development Corporation | Methods and compositions for promoting immunopotentiation |
US6025165A (en) | 1991-11-25 | 2000-02-15 | Enzon, Inc. | Methods for producing multivalent antigen-binding proteins |
GB9206422D0 (en) | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6805869B2 (en) * | 1996-06-12 | 2004-10-19 | Shanghai Cp Guojian Pharmaceutical Co., Ltd. | Cellular vaccines and immunotherapeutics and methods for their preparation |
EP0979281B1 (en) | 1997-05-02 | 2005-07-20 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
WO1999061057A2 (en) | 1998-05-23 | 1999-12-02 | Tanox, Inc. | Molecules targeting cd40 and tumor cells |
WO2000006605A2 (en) | 1998-07-28 | 2000-02-10 | Micromet Ag | Heterominibodies |
WO2000018806A1 (en) | 1998-09-25 | 2000-04-06 | Horst Lindhofer | Bispecific and trispecific antibodies which specifically react with inducible surface antigens as operational target structures |
PL209786B1 (en) | 1999-01-15 | 2011-10-31 | Genentech Inc | Variant of mother polypeptide containing Fc region, polypeptide containing variant of Fc region with altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant |
US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
HUP0200484A2 (en) | 1999-03-11 | 2002-06-29 | Micromet Ag | Antibody and chemokine constructs that are directed to ccr5, and their use for treating autoimmune diseases |
KR20020093029A (en) | 2000-04-11 | 2002-12-12 | 제넨테크, 인크. | Multivalent Antibodies And Uses Therefor |
JP2004511430A (en) | 2000-05-24 | 2004-04-15 | イムクローン システムズ インコーポレイティド | Bispecific immunoglobulin-like antigen binding protein and production method |
DE10034607A1 (en) | 2000-07-20 | 2002-02-07 | Gundram Jung | Multi-specific reagent for the selective stimulation of cell surface receptors |
WO2002020615A2 (en) | 2000-09-08 | 2002-03-14 | Micromet Ag | Antibody and/or chemokine constructs which bind to a chemokine receptor and their use in immunological disorders |
CN1294148C (en) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | Single-stranded cyctic trispecific antibody |
MXPA04003798A (en) | 2001-10-25 | 2004-07-30 | Genentech Inc | Glycoprotein compositions. |
US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
KR20040088572A (en) | 2002-03-01 | 2004-10-16 | 이뮤노메딕스, 인코오포레이티드 | Bispecific antibody point mutations for enhancing rate of clearance |
CN1678634A (en) | 2002-06-28 | 2005-10-05 | 多曼蒂斯有限公司 | Immunoglobulin single variable antigen combination area and its opposite constituent |
US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
CN101928344B (en) | 2002-10-17 | 2014-08-13 | 根马布股份公司 | Human monoclonal antibodies against cd20 |
EP2270051B1 (en) | 2003-01-23 | 2019-05-15 | Ono Pharmaceutical Co., Ltd. | Antibody specific for human PD-1 and CD3 |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
KR100973564B1 (en) | 2003-05-02 | 2010-08-03 | 젠코어 인코포레이티드 | OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION |
US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
EP1756162A1 (en) | 2004-03-23 | 2007-02-28 | Biogen Idec MA Inc. | Receptor coupling agents and therapeutic uses thereof |
GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
SG188175A1 (en) | 2004-06-03 | 2013-03-28 | Novimmune Sa | Anti-cd3 antibodies and methods of use thereof |
EP2314317A3 (en) | 2004-07-09 | 2011-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican 3 antibody |
EP1776384B1 (en) | 2004-08-04 | 2013-06-05 | Mentrik Biotech, LLC | Variant fc regions |
WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
AU2006204791A1 (en) | 2005-01-12 | 2006-07-20 | Xencor, Inc | Antibodies and Fc fusion proteins with altered immunogenicity |
WO2006106905A1 (en) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
AU2006230413B8 (en) | 2005-03-31 | 2011-01-20 | Xencor, Inc | Fc variants with optimized properties |
EP3214095B1 (en) * | 2005-05-12 | 2019-12-11 | ZymoGenetics, Inc. | Compositions and methods for modulating immune responses |
EP1820513A1 (en) | 2006-02-15 | 2007-08-22 | Trion Pharma Gmbh | Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies |
TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
WO2007110205A2 (en) | 2006-03-24 | 2007-10-04 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
JP2009539841A (en) | 2006-06-06 | 2009-11-19 | トラークス,インコーポレイテッド | Administration of anti-CD3 antibodies in the treatment of autoimmune diseases |
US20090182127A1 (en) | 2006-06-22 | 2009-07-16 | Novo Nordisk A/S | Production of Bispecific Antibodies |
JP2009543868A (en) | 2006-07-17 | 2009-12-10 | クインテセンス バイオサイエンシーズ インコーポレーティッド | Methods and compositions for cancer treatment |
GB0620894D0 (en) * | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
US8398956B2 (en) * | 2007-01-11 | 2013-03-19 | Immunomedics, Inc. | In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents |
WO2008090960A1 (en) | 2007-01-24 | 2008-07-31 | Kyowa Hakko Kirin Co., Ltd. | Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2 |
CN104497143B (en) | 2007-03-29 | 2020-08-25 | 健玛保 | Bispecific antibody and method for producing same |
CN101802011A (en) | 2007-06-29 | 2010-08-11 | 先灵公司 | mdl-1 uses |
ES2687808T3 (en) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Constant region of modified antibody |
ES2400107T3 (en) | 2007-10-22 | 2013-04-05 | Merck Serono S.A. | Single IFN-beta fused to an Fc fragment of mutated lgG |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
EP2235064B1 (en) | 2008-01-07 | 2015-11-25 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
ES2618292T3 (en) | 2008-01-31 | 2017-06-21 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Antibodies against and use of human CD39 to inhibit the activity of regulatory T cells |
WO2009100140A1 (en) | 2008-02-04 | 2009-08-13 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
ES2456296T3 (en) | 2008-03-27 | 2014-04-21 | Zymogenetics, Inc. | Compositions and procedures for inhibiting PDGFR beta and VEGF-A |
KR20110008086A (en) * | 2008-04-11 | 2011-01-25 | 메리맥 파마슈티컬즈, 인크. | Human serum albumin linkers and conjugates thereof |
KR20110014607A (en) | 2008-04-29 | 2011-02-11 | 아보트 러보러터리즈 | Dual variable domain immunoglobulins and uses thereof |
AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
CA2736408A1 (en) | 2008-09-26 | 2010-04-01 | Roche Glycart Ag | Bispecific anti-egfr/anti-igf-1r antibodies |
BRPI0919840B1 (en) | 2008-10-01 | 2023-02-28 | Amgen Research (Munich) Gmbh | BISPECIFIC SINGLE CHAIN ANTIBODY MOLECULE, ITS USE, AND PHARMACEUTICAL COMPOSITION COMPRISING IT |
EP2337795A2 (en) | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
US8927694B2 (en) | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
DE202008016028U1 (en) | 2008-12-04 | 2010-04-15 | Melitta Haushaltsprodukte Gmbh & Co. Kg | Containers for storing objects |
US20120100140A1 (en) * | 2009-01-23 | 2012-04-26 | Biogen Idec Ma Inc. | Stabilized fc polypeptides with reduced effector function and methods of use |
HRP20221259T1 (en) | 2009-02-13 | 2022-12-09 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
NZ611324A (en) | 2009-03-05 | 2015-02-27 | Abbvie Inc | Il-17 binding proteins |
JP5717624B2 (en) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | Antibody constant region variants |
AU2010236787A1 (en) | 2009-04-01 | 2011-11-10 | Genentech, Inc. | Anti-FcRH5 antibodies and immunoconjugates and methods of use |
ES2708124T3 (en) | 2009-04-27 | 2019-04-08 | Oncomed Pharm Inc | Procedure for preparing heteromultimeric molecules |
TW201100543A (en) | 2009-05-27 | 2011-01-01 | Hoffmann La Roche | Tri-or tetraspecific antibodies |
MX342623B (en) | 2009-06-26 | 2016-10-06 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format. |
AU2010303142B2 (en) * | 2009-09-29 | 2013-05-09 | Roche Glycart Ag | Bispecific death receptor agonistic antibodies |
CA2778334A1 (en) | 2009-10-20 | 2011-04-28 | Charlotte Mckee | Anti-cd3 antibody dosing in autoimmune disease |
US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
WO2011108714A1 (en) | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | Antibody constant region variant |
TWI653333B (en) | 2010-04-01 | 2019-03-11 | 安進研究(慕尼黑)有限責任公司 | Cross-species specific PSMAxCD3 bispecific single chain antibody |
CN103097417B (en) | 2010-04-20 | 2019-04-09 | 根马布股份公司 | Albumen of the FC containing heterodimeric antibodies and preparation method thereof |
EP2560683B2 (en) | 2010-04-23 | 2022-07-20 | F. Hoffmann-La Roche AG | Production of heteromultimeric proteins |
JP6022444B2 (en) | 2010-05-14 | 2016-11-09 | ライナット ニューロサイエンス コーポレイション | Heterodimeric protein and method for producing and purifying it |
CN103154035B (en) | 2010-05-27 | 2017-05-10 | 根马布股份公司 | Monoclonal antibodies against her2 |
AU2011325833C1 (en) | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
PL2647707T3 (en) | 2010-11-30 | 2019-02-28 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
EP2654792A4 (en) | 2010-12-22 | 2016-05-11 | Abbvie Inc | Half immunoglobulin binding proteins and uses thereof |
JP5828909B2 (en) * | 2011-01-10 | 2015-12-09 | シーティー アトランティック リミテッド | Combination therapy including tumor-associated antigen-binding antibody |
EP2673297A2 (en) | 2011-02-11 | 2013-12-18 | Zyngenia, Inc. | Monovalent and multivalent multispecific complexes and uses thereof |
EP2679681B2 (en) * | 2011-02-25 | 2023-11-15 | Chugai Seiyaku Kabushiki Kaisha | FcgammaRIIB-specific FC antibody |
DK2698431T3 (en) | 2011-03-30 | 2020-11-30 | Chugai Pharmaceutical Co Ltd | Maintenance of antigen-binding molecules in blood plasma and method of modifying immunogenicity |
US20140178368A1 (en) * | 2011-04-19 | 2014-06-26 | Leslie Lynne SHARP | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
EP2537864B1 (en) * | 2011-06-24 | 2019-08-07 | Laboratoire Français du Fractionnement et des Biotechnologies | Fc variants with reduced effector functions |
PT2726101T (en) | 2011-06-30 | 2018-11-21 | Genzyme Corp | Inhibitors of t-cell activation |
BR112014003598B1 (en) | 2011-08-23 | 2022-05-31 | Roche Glycart Ag | Bispecific antigen binding molecule, pharmaceutical composition and use of the bispecific antigen binding molecule |
PE20141521A1 (en) | 2011-08-23 | 2014-10-25 | Roche Glycart Ag | T-CELL ACTIVATING ANTIGEN-BINDING BI-SPECIFIC MOLECULES |
RU2681885C2 (en) | 2011-10-31 | 2019-03-13 | Чугаи Сейяку Кабусики Кайся | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
WO2013070468A1 (en) * | 2011-11-08 | 2013-05-16 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
EP2780372B1 (en) | 2011-11-17 | 2019-01-02 | Jung, Gundram | Bi-specific antibodies for medical use |
US9718893B2 (en) | 2011-12-19 | 2017-08-01 | Synimmune Gmbh | Bispecific antibody molecule |
EP2869845B1 (en) | 2012-07-06 | 2019-08-28 | Genmab B.V. | Dimeric protein with triple mutations |
US9315567B2 (en) | 2012-08-14 | 2016-04-19 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
JOP20200236A1 (en) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof |
JP6072495B2 (en) | 2012-10-12 | 2017-02-01 | 三菱電機株式会社 | Light source lighting device and lighting system |
CN104968364A (en) | 2012-12-03 | 2015-10-07 | 百时美施贵宝公司 | Enhancing anti-cancer activity of immunomodulatory Fc fusion proteins |
WO2014116846A2 (en) * | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
WO2014138306A1 (en) | 2013-03-05 | 2014-09-12 | Baylor College Of Medicine | Engager cells for immunotherapy |
AU2014232416B2 (en) | 2013-03-15 | 2017-09-28 | Xencor, Inc. | Modulation of T Cells with Bispecific Antibodies and FC Fusions |
US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
WO2014165818A2 (en) * | 2013-04-05 | 2014-10-09 | T Cell Therapeutics, Inc. | Compositions and methods for preventing and treating prostate cancer |
KR102363220B1 (en) * | 2013-07-05 | 2022-02-15 | 젠맵 에이/에스 | Humanized or chimeric cd3 antibodies |
EP3050896B1 (en) * | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
JP2016538275A (en) | 2013-11-04 | 2016-12-08 | グレンマーク ファーマシューティカルズ, エセ.アー. | Production of T-cell retargeting heterodimeric immunoglobulins |
WO2015095392A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
CN106459182B (en) | 2013-12-30 | 2021-09-03 | 岸迈生物科技有限公司 | Tandem FAB immunoglobulins and uses thereof |
AU2015220762B2 (en) | 2014-02-21 | 2019-05-02 | Cellectis | Method for in situ inhibition of regulatory T cells |
CN111410691B (en) | 2014-03-28 | 2024-02-13 | Xencor公司 | Bispecific antibodies that bind to CD38 and CD3 |
ES2900898T3 (en) | 2014-04-07 | 2022-03-18 | Chugai Pharmaceutical Co Ltd | Bispecific immunoactivating antibodies |
CA2947157A1 (en) | 2014-05-13 | 2015-11-19 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
MA40764A (en) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENT INDUCING CYTOTOXICITY |
US20180171017A1 (en) | 2015-06-05 | 2018-06-21 | Chugai Seiyaku Kabushiki Kaisha | Combined use of immune activators |
WO2017010423A1 (en) | 2015-07-10 | 2017-01-19 | 中外製薬株式会社 | Non-human animal having human cd3 gene substituted for endogenous cd3 gene |
US11649293B2 (en) | 2015-11-18 | 2023-05-16 | Chugai Seiyaku Kabushiki Kaisha | Method for enhancing humoral immune response |
US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
KR20180116215A (en) | 2016-03-14 | 2018-10-24 | 추가이 세이야쿠 가부시키가이샤 | Cytotoxicity-inducing therapeutic agent for treating cancer |
JP2020518584A (en) | 2017-05-02 | 2020-06-25 | 中外製薬株式会社 | Cell injury-inducing therapeutic agent |
SG11201810270SA (en) | 2017-09-29 | 2019-04-29 | Chugai Pharmaceutical Co Ltd | Multispecific antigen-binding molecules having blood coagulation factor viii (fviii) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ing |
MX2020012286A (en) | 2018-05-16 | 2021-04-28 | Janssen Biotech Inc | Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy. |
-
2015
- 2015-04-07 ES ES15776419T patent/ES2900898T3/en active Active
- 2015-04-07 CA CA2943943A patent/CA2943943C/en active Active
- 2015-04-07 AU AU2015244814A patent/AU2015244814B2/en active Active
- 2015-04-07 MX MX2016012552A patent/MX2016012552A/en unknown
- 2015-04-07 MY MYPI2016703655A patent/MY194892A/en unknown
- 2015-04-07 KR KR1020167029795A patent/KR102568808B1/en active IP Right Grant
- 2015-04-07 TW TW104111074A patent/TWI726842B/en active
- 2015-04-07 RU RU2016143383A patent/RU2722788C2/en active
- 2015-04-07 JP JP2016512734A patent/JP6629187B2/en active Active
- 2015-04-07 CN CN202410651699.1A patent/CN118440206A/en active Pending
- 2015-04-07 SG SG11201607434WA patent/SG11201607434WA/en unknown
- 2015-04-07 BR BR112016022912A patent/BR112016022912A2/en not_active Application Discontinuation
- 2015-04-07 WO PCT/JP2015/060794 patent/WO2015156268A1/en active Application Filing
- 2015-04-07 US US15/302,439 patent/US11485790B2/en active Active
- 2015-04-07 CN CN201580025214.7A patent/CN106459206B/en active Active
- 2015-04-07 EP EP15776419.2A patent/EP3130606B1/en active Active
- 2015-04-07 IL IL247715A patent/IL247715B/en unknown
- 2015-04-07 PL PL15776419T patent/PL3130606T3/en unknown
-
2019
- 2019-12-04 JP JP2019219236A patent/JP7015819B2/en active Active
-
2022
- 2022-09-21 US US17/933,879 patent/US20230151112A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN118440206A (en) | 2024-08-06 |
RU2016143383A3 (en) | 2018-11-09 |
US11485790B2 (en) | 2022-11-01 |
JP7015819B2 (en) | 2022-02-03 |
AU2015244814A1 (en) | 2016-09-22 |
TW201613965A (en) | 2016-04-16 |
KR102568808B1 (en) | 2023-08-18 |
NZ724710A (en) | 2024-02-23 |
WO2015156268A1 (en) | 2015-10-15 |
EP3130606B1 (en) | 2021-10-13 |
MY194892A (en) | 2022-12-22 |
BR112016022912A2 (en) | 2017-10-17 |
RU2016143383A (en) | 2018-05-07 |
TWI726842B (en) | 2021-05-11 |
MX2016012552A (en) | 2017-01-09 |
PL3130606T3 (en) | 2022-02-07 |
IL247715A0 (en) | 2016-11-30 |
CA2943943C (en) | 2023-01-10 |
AU2015244814B2 (en) | 2020-12-24 |
KR20160142332A (en) | 2016-12-12 |
JP2020063270A (en) | 2020-04-23 |
RU2722788C2 (en) | 2020-06-03 |
ES2900898T3 (en) | 2022-03-18 |
EP3130606A4 (en) | 2017-10-25 |
US20230151112A1 (en) | 2023-05-18 |
EP3130606A1 (en) | 2017-02-15 |
CN106459206B (en) | 2024-06-07 |
JPWO2015156268A1 (en) | 2017-04-13 |
CN106459206A (en) | 2017-02-22 |
US20170022287A1 (en) | 2017-01-26 |
JP6629187B2 (en) | 2020-01-15 |
IL247715B (en) | 2022-07-01 |
CA2943943A1 (en) | 2015-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL247715A0 (en) | Immunoactivating antigen-binding molecule | |
IL285366A (en) | Multispecific antigen-binding proteins | |
IL288649A (en) | Humanized anti-tau antibodies | |
IL250583A0 (en) | Anti-tigit antibodies | |
SG11201703346PA (en) | Anti-tim-3 antibodies | |
SI3131928T2 (en) | Trifunctional antigen-binding molecule | |
GB201421379D0 (en) | Molecule | |
HK1244008A1 (en) | Improved il-6 antibodies | |
IL252422A0 (en) | Effector-deficient anti-cd32a antibodies | |
PT3101131T (en) | Anti-transthyretin humanized antibody | |
IL250374B (en) | Anti-ceramide antibodies | |
SG11201606347XA (en) | Deposition apparatus | |
TWI561682B (en) | Deposition apparatus | |
GB201409759D0 (en) | Molecule | |
GB201403479D0 (en) | Molecule | |
GB201419092D0 (en) | Anti-TIM-3 antibodies | |
GB201419089D0 (en) | Anti-TIM-3 antibodies | |
GB201417614D0 (en) | Antibodies | |
GB201414270D0 (en) | Antibodies | |
GB201405775D0 (en) | Antibodies | |
GB201401200D0 (en) | Antibodies |