CA2892529C - Terminally modified rna - Google Patents

Terminally modified rna Download PDF

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Publication number
CA2892529C
CA2892529C CA2892529A CA2892529A CA2892529C CA 2892529 C CA2892529 C CA 2892529C CA 2892529 A CA2892529 A CA 2892529A CA 2892529 A CA2892529 A CA 2892529A CA 2892529 C CA2892529 C CA 2892529C
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CA
Canada
Prior art keywords
mir
cap
microrna
mrna
utr
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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CA2892529A
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English (en)
French (fr)
Other versions
CA2892529A1 (en
Inventor
Tirtha Chakraborty
Stephane Bancel
Stephen G. HOGE
Atanu Roy
Antonin De Fougerolles
Noubar B. Afeyan
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ModernaTx Inc
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ModernaTx Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49447811&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2892529(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ModernaTx Inc filed Critical ModernaTx Inc
Publication of CA2892529A1 publication Critical patent/CA2892529A1/en
Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CA2892529A 2012-11-26 2013-10-02 Terminally modified rna Active CA2892529C (en)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201261729933P 2012-11-26 2012-11-26
US61/729,933 2012-11-26
US201261737224P 2012-12-14 2012-12-14
US61/737,224 2012-12-14
US201361758921P 2013-01-31 2013-01-31
US61/758,921 2013-01-31
US201361775509P 2013-03-09 2013-03-09
US61/775,509 2013-03-09
US201361781139P 2013-03-14 2013-03-14
US61/781,139 2013-03-14
US201361829359P 2013-05-31 2013-05-31
US201361829372P 2013-05-31 2013-05-31
US61/829,359 2013-05-31
US61/829,372 2013-05-31
US201361839903P 2013-06-27 2013-06-27
US61/839,903 2013-06-27
US201361842709P 2013-07-03 2013-07-03
US61/842,709 2013-07-03
US201361857436P 2013-07-23 2013-07-23
US61/857,436 2013-07-23
PCT/US2013/062943 WO2014081507A1 (en) 2012-11-26 2013-10-02 Terminally modified rna

Publications (2)

Publication Number Publication Date
CA2892529A1 CA2892529A1 (en) 2014-05-30
CA2892529C true CA2892529C (en) 2023-04-25

Family

ID=49447811

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2892529A Active CA2892529C (en) 2012-11-26 2013-10-02 Terminally modified rna

Country Status (16)

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US (5) US9597380B2 (enExample)
EP (2) EP4074834A1 (enExample)
JP (5) JP6144355B2 (enExample)
AU (3) AU2017202228B2 (enExample)
CA (1) CA2892529C (enExample)
CY (1) CY1125236T1 (enExample)
DK (1) DK2922554T3 (enExample)
ES (1) ES2921623T3 (enExample)
HR (1) HRP20220607T1 (enExample)
LT (1) LT2922554T (enExample)
PL (1) PL2922554T3 (enExample)
PT (1) PT2922554T (enExample)
RS (1) RS63237B1 (enExample)
SI (1) SI2922554T1 (enExample)
SM (1) SMT202200337T1 (enExample)
WO (1) WO2014081507A1 (enExample)

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* Cited by examiner, † Cited by third party
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