RU2014104090A - Липосомы с эффективным соотношением n:p для доставки молекул phk - Google Patents
Липосомы с эффективным соотношением n:p для доставки молекул phk Download PDFInfo
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- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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Abstract
1. Липосома, в которую инкапсулирована иммуноген-кодирующая РНК, где липосома содержит катионный липид, и соотношение N:P липосомы и РНК составляет от 1:1 до 20:1.2. Липосома по п.1, диаметр которой находится в интервале от 50 до 220 нм.3. Липосома по п.1, в которой РНК представляет собой самореплицирующуюся РНК.4. Липосома по п.3, в которой самореплицирующаяся РНК кодирует (i) РНК-зависимую РНК-полимеазу, которая может транскрибировать РНК из самореплицирующейся молекулы РНК и (ii) иммуноген.5. Липосома по п.4, в которой самореплицирующаяся РНК имеет две открытые рамки считывания, первая из которых кодирует репликазу альфа-вируса, а вторая кодирует иммуноген.6. Липосома по п.2, где РНК представляет собой самореплицирующуюся РНК.7. Липосома по п.6, где самореплицирующая РНК кодирует (i) РНК-зависимую РНК-полимеазу, которая может транскрибировать РНК из самореплицирующейся молекулы РНК и (ii) иммуноген.8. Липосома по п.7, в которой самореплицирующаяся РНК имеет две открытые рамки считывания, первая из которых кодирует репликазу альфа-вируса, а вторая кодирует иммуноген.9. Липосома по любому из пп.1-8, в которой длина РНК составляет от 9000 до 12000 нуклеотидов.10. Липосома по любому из пп.1-8, в которой иммуноген может индуцировать иммунный ответ in vivo против бактерии, вируса, грибка или паразита.11. Липосома по п.10, в которой иммуноген может индуцировать иммунный ответ in vivo против гликопротеина F респираторно-синцитиального вируса.12. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет от 2:1 до 18:1.13. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет от 3:1 до 11:1.14. Липосома по любому из пп.1-8, где соотношение N:P липосо�
Claims (19)
1. Липосома, в которую инкапсулирована иммуноген-кодирующая РНК, где липосома содержит катионный липид, и соотношение N:P липосомы и РНК составляет от 1:1 до 20:1.
2. Липосома по п.1, диаметр которой находится в интервале от 50 до 220 нм.
3. Липосома по п.1, в которой РНК представляет собой самореплицирующуюся РНК.
4. Липосома по п.3, в которой самореплицирующаяся РНК кодирует (i) РНК-зависимую РНК-полимеазу, которая может транскрибировать РНК из самореплицирующейся молекулы РНК и (ii) иммуноген.
5. Липосома по п.4, в которой самореплицирующаяся РНК имеет две открытые рамки считывания, первая из которых кодирует репликазу альфа-вируса, а вторая кодирует иммуноген.
6. Липосома по п.2, где РНК представляет собой самореплицирующуюся РНК.
7. Липосома по п.6, где самореплицирующая РНК кодирует (i) РНК-зависимую РНК-полимеазу, которая может транскрибировать РНК из самореплицирующейся молекулы РНК и (ii) иммуноген.
8. Липосома по п.7, в которой самореплицирующаяся РНК имеет две открытые рамки считывания, первая из которых кодирует репликазу альфа-вируса, а вторая кодирует иммуноген.
9. Липосома по любому из пп.1-8, в которой длина РНК составляет от 9000 до 12000 нуклеотидов.
10. Липосома по любому из пп.1-8, в которой иммуноген может индуцировать иммунный ответ in vivo против бактерии, вируса, грибка или паразита.
11. Липосома по п.10, в которой иммуноген может индуцировать иммунный ответ in vivo против гликопротеина F респираторно-синцитиального вируса.
12. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет от 2:1 до 18:1.
13. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет от 3:1 до 11:1.
14. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет от 4:1 до 16:1.
15. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет от 6:1 до 14:1.
16. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет от 8:1 до 12:1.
17. Липосома по любому из пп.1-8, где соотношение N:P липосомы и РНК составляет 2:1, 4:1, 8:1 или 10:1.
18. Фармацевтическая композиция, содержащая липосому по любому из пп.1-17.
19. Способ повышения защитного иммунного ответа у позвоночного, включающий стадию введения позвоночному эффективного количества липосомы по пп.1-17, или фармацевтической композиции по п.18.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505088P | 2011-07-06 | 2011-07-06 | |
| US61/505,088 | 2011-07-06 | ||
| PCT/US2012/045829 WO2013006825A1 (en) | 2011-07-06 | 2012-07-06 | Liposomes having useful n:p ratio for delivery of rna molecules |
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| Publication Number | Publication Date |
|---|---|
| RU2014104090A true RU2014104090A (ru) | 2015-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2014104090/10A RU2014104090A (ru) | 2011-07-06 | 2012-07-06 | Липосомы с эффективным соотношением n:p для доставки молекул phk |
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| Country | Link |
|---|---|
| US (2) | US20140141070A1 (ru) |
| EP (5) | EP3821879A1 (ru) |
| JP (2) | JP2014520806A (ru) |
| CN (1) | CN103764121A (ru) |
| BR (1) | BR112014000236A2 (ru) |
| CA (1) | CA2840977A1 (ru) |
| ES (1) | ES2861428T3 (ru) |
| MX (1) | MX350764B (ru) |
| RU (1) | RU2014104090A (ru) |
| SG (1) | SG10201605537XA (ru) |
| WO (1) | WO2013006825A1 (ru) |
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| EP2729126A1 (en) | 2014-05-14 |
| BR112014000236A2 (pt) | 2017-02-14 |
| US20200113831A1 (en) | 2020-04-16 |
| EP2729126B1 (en) | 2020-12-23 |
| CA2840977A1 (en) | 2013-01-10 |
| US20140141070A1 (en) | 2014-05-22 |
| WO2013006825A1 (en) | 2013-01-10 |
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