|
US6811779B2
(en)
|
1994-02-10 |
2004-11-02 |
Imclone Systems Incorporated |
Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
|
|
TW321649B
(https=)
*
|
1994-11-12 |
1997-12-01 |
Zeneca Ltd |
|
|
GB9424233D0
(en)
*
|
1994-11-30 |
1995-01-18 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9508537D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9508535D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivative
|
|
GB9508565D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
|
JPH11507329A
(ja)
*
|
1995-04-27 |
1999-06-29 |
ゼネカ リミテッド |
キナゾリン誘導体
|
|
US7060808B1
(en)
*
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
|
GB9624482D0
(en)
*
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
DE69720965T2
(de)
|
1996-02-13 |
2004-02-05 |
Astrazeneca Ab |
Chinazolinderivate und deren verwendung als vegf hemmer
|
|
GB9603097D0
(en)
*
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
NZ331191A
(en)
|
1996-03-05 |
2000-03-27 |
Zeneca Ltd |
4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
|
|
EA001595B1
(ru)
|
1996-04-12 |
2001-06-25 |
Варнер-Ламберт Компани |
Необратимые ингибиторы тирозинкиназ
|
|
GB9607729D0
(en)
*
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
CA2299471C
(en)
*
|
1997-08-15 |
2007-12-18 |
Cephalon Inc. |
Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer
|
|
ES2289791T3
(es)
|
1997-08-22 |
2008-02-01 |
Astrazeneca Ab |
Derivados de oxindolilquinazolina como inhibidores de la angiogenesis.
|
|
US20030224001A1
(en)
*
|
1998-03-19 |
2003-12-04 |
Goldstein Neil I. |
Antibody and antibody fragments for inhibiting the growth of tumors
|
|
US6887674B1
(en)
|
1998-04-13 |
2005-05-03 |
California Institute Of Technology |
Artery- and vein-specific proteins and uses therefor
|
|
US6864227B1
(en)
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
|
ZA200007412B
(en)
*
|
1998-05-15 |
2002-03-12 |
Imclone Systems Inc |
Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
|
|
US7354894B2
(en)
*
|
1998-08-18 |
2008-04-08 |
The Regents Of The University Of California |
Preventing airway mucus production by administration of EGF-R antagonists
|
|
US6270747B1
(en)
|
1998-08-18 |
2001-08-07 |
The University Of California |
In vitro and in vivo assay for agents which treat mucus hypersecretion
|
|
KR20010089171A
(ko)
|
1998-08-21 |
2001-09-29 |
추후제출 |
퀴나졸린 유도체
|
|
IL142092A0
(en)
|
1998-09-29 |
2002-03-10 |
American Cyanamid Co |
Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
|
|
US6288082B1
(en)
|
1998-09-29 |
2001-09-11 |
American Cyanamid Company |
Substituted 3-cyanoquinolines
|
|
US6297258B1
(en)
|
1998-09-29 |
2001-10-02 |
American Cyanamid Company |
Substituted 3-cyanoquinolines
|
|
ATE293989T1
(de)
*
|
1998-11-20 |
2005-05-15 |
Genentech Inc |
Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
|
|
CA2361174C
(en)
|
1999-02-27 |
2009-10-27 |
Boehringer Ingelheim Pharma Kg |
4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases
|
|
DE19911509A1
(de)
*
|
1999-03-15 |
2000-09-21 |
Boehringer Ingelheim Pharma |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
CZ20014083A3
(cs)
*
|
1999-05-14 |
2002-08-14 |
Imclone Systems Incorporated |
Léčivo pro indikaci růstu refrakterních nádorů
|
|
HK1044769B
(zh)
|
1999-06-21 |
2005-02-25 |
贝林格尔英格海姆法玛两合公司 |
雙環雜環化合物，含有該化合物的藥物組合物，該化合物的用途及其製備方法
|
|
US6432979B1
(en)
|
1999-08-12 |
2002-08-13 |
American Cyanamid Company |
Method of treating or inhibiting colonic polyps and colorectal cancer
|
|
GB9925958D0
(en)
*
|
1999-11-02 |
1999-12-29 |
Bundred Nigel J |
Therapeutic use
|
|
KR100881105B1
(ko)
*
|
1999-11-05 |
2009-02-02 |
아스트라제네카 아베 |
Ｖｅｇｆ 억제제로서의 퀴나졸린 유도체
|
|
US20020002169A1
(en)
|
1999-12-08 |
2002-01-03 |
Griffin John H. |
Protein kinase inhibitors
|
|
GB0002952D0
(en)
*
|
2000-02-09 |
2000-03-29 |
Pharma Mar Sa |
Process for producing kahalalide F compounds
|
|
GB0007371D0
(en)
|
2000-03-28 |
2000-05-17 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
GB0008368D0
(en)
*
|
2000-04-06 |
2000-05-24 |
Astrazeneca Ab |
Combination product
|
|
ES2267748T3
(es)
|
2000-04-07 |
2007-03-16 |
Astrazeneca Ab |
Compuestos de quinazolina.
|
|
EP1170011A1
(en)
*
|
2000-07-06 |
2002-01-09 |
Boehringer Ingelheim International GmbH |
Novel use of inhibitors of the epidermal growth factor receptor
|
|
WO2002011677A2
(en)
*
|
2000-08-09 |
2002-02-14 |
Imclone Systems Incorporated |
Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
|
|
US6740651B2
(en)
|
2000-08-26 |
2004-05-25 |
Boehringer Ingelheim Pharma Kg |
Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
|
|
US6656946B2
(en)
|
2000-08-26 |
2003-12-02 |
Boehringer Ingelheim Pharma Kg |
Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
|
|
DE10042059A1
(de)
*
|
2000-08-26 |
2002-03-07 |
Boehringer Ingelheim Pharma |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
US6617329B2
(en)
|
2000-08-26 |
2003-09-09 |
Boehringer Ingelheim Pharma Kg |
Aminoquinazolines and their use as medicaments
|
|
US6403580B1
(en)
|
2000-08-26 |
2002-06-11 |
Boehringer Ingelheim Pharma Kg |
Quinazolines, pharmaceutical compositions containing these compounds, their use and processes for preparing them
|
|
DE10042058A1
(de)
*
|
2000-08-26 |
2002-03-07 |
Boehringer Ingelheim Pharma |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
AU2001292137A1
(en)
*
|
2000-10-13 |
2002-04-22 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
AU9598601A
(en)
|
2000-10-20 |
2002-04-29 |
Eisai Co Ltd |
Nitrogenous aromatic ring compounds
|
|
US7776315B2
(en)
|
2000-10-31 |
2010-08-17 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pharmaceutical compositions based on anticholinergics and additional active ingredients
|
|
DE10206505A1
(de)
*
|
2002-02-16 |
2003-08-28 |
Boehringer Ingelheim Pharma |
Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern
|
|
JP4564713B2
(ja)
|
2000-11-01 |
2010-10-20 |
ミレニアム・ファーマシューティカルズ・インコーポレイテッド |
窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法
|
|
US7019012B2
(en)
|
2000-12-20 |
2006-03-28 |
Boehringer Ingelheim International Pharma Gmbh & Co. Kg |
Quinazoline derivatives and pharmaceutical compositions containing them
|
|
MX368013B
(es)
|
2001-02-19 |
2019-09-13 |
Novartis Ag |
Tratamiento de cáncer.
|
|
US20080008704A1
(en)
*
|
2001-03-16 |
2008-01-10 |
Mark Rubin |
Methods of treating colorectal cancer with anti-epidermal growth factor antibodies
|
|
CA2444867C
(en)
|
2001-05-16 |
2010-08-17 |
Novartis Ag |
Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
|
|
US7132427B2
(en)
|
2001-06-21 |
2006-11-07 |
Ariad Pharmaceuticals, Inc. |
Quinazolines and uses thereof
|
|
WO2003055491A1
(en)
*
|
2001-12-24 |
2003-07-10 |
Astrazeneca Ab |
Substituted quinazoline derivatives as inhibitors of aurora kinases
|
|
DE10204462A1
(de)
*
|
2002-02-05 |
2003-08-07 |
Boehringer Ingelheim Pharma |
Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
|
|
WO2003066602A1
(en)
|
2002-02-06 |
2003-08-14 |
Ube Industries, Ltd. |
Process for producing 4-aminoquinazoline compound
|
|
KR20040086452A
(ko)
*
|
2002-02-26 |
2004-10-08 |
아스트라제네카 아베 |
항암 화합물 ｚｄ1839의 신규한 결정질 형태
|
|
BRPI0307786B8
(pt)
|
2002-02-26 |
2021-05-25 |
Astrazeneca Ab |
composição farmacêutica, método para preparar a mesma, métodos para inibir a taxa de precipitação do agente da solução no trato gi, e para reduzir variabilidade inter-pacientes no que se refere à biodisponibilidade e/ou concentrações plásmáticas do agente, e, uso de um celulose éter solúvel em água ou de um éster de um celulose éter solúvel em água
|
|
GB0204392D0
(en)
*
|
2002-02-26 |
2002-04-10 |
Astrazeneca Ab |
Pharmaceutical compound
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
GB0206215D0
(en)
*
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
RU2345989C2
(ru)
*
|
2002-03-28 |
2009-02-10 |
Астразенека Аб |
Производные 4-анилино-хиназолина, способ их получения (варианты), фармацевтическая композиция, способ ингибирования пролиферативного действия и способ лечения рака у теплокровного животного
|
|
TWI324597B
(en)
*
|
2002-03-28 |
2010-05-11 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
US6924285B2
(en)
|
2002-03-30 |
2005-08-02 |
Boehringer Ingelheim Pharma Gmbh & Co. |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
|
|
BR0309226A
(pt)
*
|
2002-04-16 |
2005-02-09 |
Astrazeneca Ab |
Métodos para a produção de um efeito de danificação vascular em um animal de sangue quente, e para o tratamento de um câncer envolvendo um tumor sólido em um animal de sangue quente, composição farmacêutica, kit, e, usos de zd6126 ou de um seu sal farmaceuticamente aceitável, e de zd1839 ou de um seu sal farmaceuticamente aceitável
|
|
DE10221018A1
(de)
|
2002-05-11 |
2003-11-27 |
Boehringer Ingelheim Pharma |
Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
|
|
PT1505959E
(pt)
|
2002-05-16 |
2009-02-05 |
Novartis Ag |
Utilização de agentes de ligação do receptor edg em cancro
|
|
US20040048887A1
(en)
*
|
2002-07-09 |
2004-03-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
|
|
WO2004008099A2
(en)
|
2002-07-15 |
2004-01-22 |
Genentech, Inc. |
METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES
|
|
US7576074B2
(en)
|
2002-07-15 |
2009-08-18 |
Rice Kenneth D |
Receptor-type kinase modulators and methods of use
|
|
GB0221245D0
(en)
*
|
2002-09-13 |
2002-10-23 |
Astrazeneca Ab |
Chemical process
|
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
GB0223854D0
(en)
*
|
2002-10-12 |
2002-11-20 |
Astrazeneca Ab |
Therapeutic treatment
|
|
GB0304367D0
(en)
*
|
2003-02-26 |
2003-04-02 |
Pharma Mar Sau |
Methods for treating psoriasis
|
|
AU2003278383B2
(en)
*
|
2002-11-04 |
2007-06-14 |
Astrazeneca Ab |
Quinazoline derivatives as Src tyrosine kinase inhibitors
|
|
WO2004046101A2
(en)
|
2002-11-20 |
2004-06-03 |
Array Biopharma, Inc. |
Cyanoguanidines and cyanoamidines as erbb2 and egfr inhibitors
|
|
US20060167026A1
(en)
*
|
2003-01-06 |
2006-07-27 |
Hiroyuki Nawa |
Antipsychotic molecular-targeting epithelial growth factor receptor
|
|
MXPA05007485A
(es)
|
2003-01-14 |
2006-01-30 |
Arena Pharm Inc |
Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
|
|
GB0302882D0
(en)
*
|
2003-02-07 |
2003-03-12 |
Univ Cardiff |
Improvements in or relating to agents for the treatment of cardiovascular dysfunction and weight loss
|
|
US7223749B2
(en)
|
2003-02-20 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
|
|
ATE508747T1
(de)
|
2003-03-10 |
2011-05-15 |
Eisai R&D Man Co Ltd |
C-kit kinase-hemmer
|
|
EP1606305A4
(en)
*
|
2003-03-12 |
2009-06-24 |
Vasgene Therapeutics Inc |
NUCLEIC ACID COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND TUMOR GROWTH
|
|
US7381410B2
(en)
*
|
2003-03-12 |
2008-06-03 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
|
EP1622941A2
(en)
*
|
2003-03-20 |
2006-02-08 |
ImClone Systems Incorporated |
Method of producing an antibody to epidermal growth factor receptor
|
|
GB0309850D0
(en)
|
2003-04-30 |
2003-06-04 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
GB0310401D0
(en)
*
|
2003-05-07 |
2003-06-11 |
Astrazeneca Ab |
Therapeutic agent
|
|
CL2004001120A1
(es)
|
2003-05-19 |
2005-04-15 |
Irm Llc |
Compuestos derivados de amina sustituidas con heterociclos, inmunosupresores; composicion farmaceutica; y uso para tratar enfermedades mediadas por interacciones de linfocito, tales como enfermedades autoinmunes, inflamatorias, infecciosas, cancer.
|
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
|
JO2785B1
(en)
*
|
2003-05-27 |
2014-03-15 |
شركة جانسين فارماسوتيكا ان. في |
Quinazoline derivatives
|
|
CA2527680A1
(en)
|
2003-05-30 |
2005-06-02 |
Astrazeneca Uk Limited |
Markers for responsiveness to an erbb receptor tyrosine kinase inhibitor
|
|
DE10326186A1
(de)
*
|
2003-06-06 |
2004-12-23 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
WO2005001053A2
(en)
|
2003-06-09 |
2005-01-06 |
Samuel Waksal |
Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
TWI476206B
(zh)
|
2003-07-18 |
2015-03-11 |
Amgen Inc |
對肝細胞生長因子具專一性之結合劑
|
|
UY28441A1
(es)
*
|
2003-07-29 |
2005-02-28 |
Astrazeneca Ab |
Derivados de quinazolina
|
|
GB0317663D0
(en)
*
|
2003-07-29 |
2003-09-03 |
Astrazeneca Ab |
Pharmaceutical composition
|
|
GB0317665D0
(en)
|
2003-07-29 |
2003-09-03 |
Astrazeneca Ab |
Qinazoline derivatives
|
|
DK1660090T3
(da)
*
|
2003-08-14 |
2012-12-17 |
Array Biopharma Inc |
Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
|
|
GB0320793D0
(en)
*
|
2003-09-05 |
2003-10-08 |
Astrazeneca Ab |
Chemical process
|
|
GB0321066D0
(en)
*
|
2003-09-09 |
2003-10-08 |
Pharma Mar Sau |
New antitumoral compounds
|
|
EP1664030A1
(en)
*
|
2003-09-16 |
2006-06-07 |
AstraZeneca AB |
Quinazoline derivatives
|
|
ATE395346T1
(de)
|
2003-09-16 |
2008-05-15 |
Astrazeneca Ab |
Chinazolinderivate als tyrosinkinaseinhibitoren
|
|
ES2279441T3
(es)
*
|
2003-09-19 |
2007-08-16 |
Astrazeneca Ab |
Derivados de quinazolina.
|
|
CN1882570B
(zh)
*
|
2003-09-19 |
2010-12-08 |
阿斯利康(瑞典)有限公司 |
喹唑啉衍生物
|
|
WO2005030757A1
(en)
*
|
2003-09-25 |
2005-04-07 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
GB0322409D0
(en)
|
2003-09-25 |
2003-10-29 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
EP2210607B1
(en)
*
|
2003-09-26 |
2011-08-17 |
Exelixis Inc. |
N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer
|
|
US7456189B2
(en)
|
2003-09-30 |
2008-11-25 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
|
|
DE10349113A1
(de)
|
2003-10-17 |
2005-05-12 |
Boehringer Ingelheim Pharma |
Verfahren zur Herstellung von Aminocrotonylverbindungen
|
|
EP2478912B1
(en)
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
US7683172B2
(en)
|
2003-11-11 |
2010-03-23 |
Eisai R&D Management Co., Ltd. |
Urea derivative and process for preparing the same
|
|
GB0326459D0
(en)
|
2003-11-13 |
2003-12-17 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
MXPA06007017A
(es)
|
2003-12-18 |
2006-08-31 |
Janssen Pharmaceutica Nv |
Derivados de pirido y pirimidopirimidina como agentes antiproliferativos.
|
|
WO2005062041A1
(en)
*
|
2003-12-24 |
2005-07-07 |
Astrazeneca Ab |
Pharmaceutical dissolution testing using a non-ionic surfactant
|
|
WO2005070909A1
(en)
*
|
2004-01-22 |
2005-08-04 |
Natco Pharma Limited |
An improved process for the preparation of gefitinib
|
|
DE602005010824D1
(de)
|
2004-02-03 |
2008-12-18 |
Astrazeneca Ab |
Chinazolinderivate
|
|
CN101072797B
(zh)
*
|
2004-03-12 |
2012-05-09 |
瓦斯基因治疗公司 |
结合ephb4、抑制血管发生和肿瘤生长的抗体
|
|
DK1730196T3
(da)
|
2004-03-12 |
2011-03-28 |
Vasgene Therapeutics Inc |
EphB4-bindende antistoffer til inhibering af antiogenese og tumorvækst
|
|
CA2560305C
(en)
*
|
2004-03-19 |
2016-07-05 |
Imclone Systems Incorporated |
Human anti-epidermal growth factor receptor antibody
|
|
ES2425749T3
(es)
|
2004-03-31 |
2013-10-17 |
The General Hospital Corporation |
Método para determinar la respuesta del cáncer a tratamientos dirigidos al receptor del factor de crecimiento epidérmico
|
|
WO2005097134A2
(en)
*
|
2004-03-31 |
2005-10-20 |
The Scripps Research Institute |
Quinazoline based protein kinase inhibitors
|
|
DK2253614T3
(da)
|
2004-04-07 |
2013-01-07 |
Novartis Ag |
IAP-inhibitorer
|
|
BRPI0510717B8
(pt)
|
2004-05-06 |
2021-05-25 |
Bioresponse Llc |
uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr)
|
|
KR20080095915A
(ko)
*
|
2004-05-06 |
2008-10-29 |
워너-램버트 캄파니 엘엘씨 |
4-페닐아미노-퀴나졸린-6-일-아미드
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
WO2006002422A2
(en)
|
2004-06-24 |
2006-01-05 |
Novartis Vaccines And Diagnostics Inc. |
Compounds for immunopotentiation
|
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
EP2471813B1
(en)
|
2004-07-15 |
2014-12-31 |
Xencor, Inc. |
Optimized Fc variants
|
|
ATE428421T1
(de)
|
2004-09-17 |
2009-05-15 |
Eisai R&D Man Co Ltd |
Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
|
|
CA2581423A1
(en)
*
|
2004-09-23 |
2006-03-30 |
Vasgene Therapeutics, Inc. |
Polipeptide compounds for inhibiting angiogenesis and tumor growth
|
|
DK1791565T3
(en)
|
2004-09-23 |
2016-08-01 |
Genentech Inc |
Cysteingensplejsede antibodies and conjugates
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
JP2008521900A
(ja)
|
2004-11-30 |
2008-06-26 |
アムジエン・インコーポレーテツド |
キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用
|
|
NI200700147A
(es)
|
2004-12-08 |
2019-05-10 |
Janssen Pharmaceutica Nv |
Derivados de quinazolina inhibidores de cinasas dirigidos a multip
|
|
JO3088B1
(ar)
*
|
2004-12-08 |
2017-03-15 |
Janssen Pharmaceutica Nv |
مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
|
|
ATE501148T1
(de)
|
2004-12-14 |
2011-03-15 |
Astrazeneca Ab |
Pyrazolopyrimidinverbindungen als antitumormittel
|
|
ATE497762T1
(de)
|
2004-12-30 |
2011-02-15 |
Bioresponse Llc |
Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus
|
|
DOP2006000010A
(es)
|
2005-01-10 |
2006-07-31 |
Arena Pharm Inc |
Procedimiento para preparar eteres aromáticos
|
|
CN101146532B
(zh)
|
2005-01-21 |
2012-05-09 |
阿斯泰克斯治疗有限公司 |
药物化合物
|
|
CN102580084B
(zh)
|
2005-01-21 |
2016-11-23 |
健泰科生物技术公司 |
Her抗体的固定剂量给药
|
|
GB0501999D0
(en)
*
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
KR101313702B1
(ko)
|
2005-02-03 |
2013-10-04 |
와이어쓰 |
제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물
|
|
US20090155247A1
(en)
*
|
2005-02-18 |
2009-06-18 |
Ashkenazi Avi J |
Methods of Using Death Receptor Agonists and EGFR Inhibitors
|
|
US20060188498A1
(en)
*
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
WO2006090413A1
(en)
*
|
2005-02-23 |
2006-08-31 |
Natco Pharma Limited |
Novel crystalline form of gefitinib and a process for its preparation
|
|
EP1850874B1
(en)
|
2005-02-23 |
2013-10-16 |
Genentech, Inc. |
Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
|
|
KR20070107151A
(ko)
|
2005-02-26 |
2007-11-06 |
아스트라제네카 아베 |
티로신 키나제 억제제로서의 퀴나졸린 유도체
|
|
SI1859793T1
(sl)
*
|
2005-02-28 |
2011-08-31 |
Eisai R&D Man Co Ltd |
Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka
|
|
US20060216288A1
(en)
*
|
2005-03-22 |
2006-09-28 |
Amgen Inc |
Combinations for the treatment of cancer
|
|
AU2006235487B2
(en)
*
|
2005-04-12 |
2011-12-22 |
Elan Pharma International Limited |
Nanoparticulate quinazoline derivative formulations
|
|
EP1871347B1
(en)
|
2005-04-19 |
2016-08-03 |
Novartis AG |
Pharmaceutical composition
|
|
CN101175734B
(zh)
*
|
2005-05-12 |
2011-10-12 |
黄文林 |
一种作为抗肿瘤药物的喹唑啉衍生物及其制备方法
|
|
WO2006119673A1
(fr)
*
|
2005-05-12 |
2006-11-16 |
Wenlin Huang |
Procede de preparation de derives de quinazoline et application pour la fabrication pour le traitement d’une maladie tumorale
|
|
CN101175733A
(zh)
*
|
2005-05-12 |
2008-05-07 |
黄文林 |
一种酪氨酸激酶抑制剂、其制备方法及作为抗肿瘤药物的应用
|
|
EP1885187B1
(en)
|
2005-05-13 |
2013-09-25 |
Novartis AG |
Methods for treating drug resistant cancer
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
CA2612449A1
(en)
|
2005-06-17 |
2006-12-28 |
Imclone Systems Incorporated |
Receptor antagonists for treatment of metastatic bone cancer
|
|
WO2007008943A2
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc. |
Optimized anti-ep-cam antibodies
|
|
ZA200800907B
(en)
*
|
2005-07-18 |
2010-04-28 |
Bipar Sciences Inc |
Treatment of cancer
|
|
WO2007015569A1
(ja)
*
|
2005-08-01 |
2007-02-08 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質の効果を予測する方法
|
|
JP4989476B2
(ja)
|
2005-08-02 |
2012-08-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質の効果を検定する方法
|
|
JP2009505658A
(ja)
|
2005-08-24 |
2009-02-12 |
ブリストル−マイヤーズ スクイブ カンパニー |
上皮増殖因子受容体モデュレーターに対する感受性を決定するためのバイオマーカーおよび方法
|
|
CN1300118C
(zh)
*
|
2005-08-25 |
2007-02-14 |
江苏吴中苏药医药开发有限责任公司 |
4－(3－氯－4－氟苯基胺基)－7－甲氧基－6－(3－吗啉丙氧基)喹唑啉的制备方法
|
|
CA2620594C
(en)
*
|
2005-09-01 |
2012-08-21 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical composition having improved disintegratability
|
|
ATE488513T1
(de)
|
2005-09-20 |
2010-12-15 |
Astrazeneca Ab |
4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs
|
|
US20070218061A1
(en)
*
|
2005-09-23 |
2007-09-20 |
Vasgene Therapeutics, Inc. |
Use of ephrinb2 directed agents for the treatment or prevention of viral infections
|
|
EP1942937A1
(en)
|
2005-11-04 |
2008-07-16 |
Wyeth |
Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
|
|
AU2006309551B2
(en)
|
2005-11-07 |
2012-04-19 |
Eisai R & D Management Co., Ltd. |
Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
|
|
JP5688877B2
(ja)
|
2005-11-11 |
2015-03-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
癌疾患の治療用キナゾリン誘導体
|
|
NO20220050A1
(no)
|
2005-11-21 |
2008-08-12 |
Novartis Ag |
Neuroendokrin tumorbehandling
|
|
EP1964837A4
(en)
*
|
2005-11-22 |
2010-12-22 |
Eisai R&D Man Co Ltd |
Antitumor agent against multiple myeloma
|
|
US7977346B2
(en)
*
|
2006-01-17 |
2011-07-12 |
Guoqing Paul Chen |
Spiro compounds and methods of use
|
|
CN101003514A
(zh)
*
|
2006-01-20 |
2007-07-25 |
上海艾力斯医药科技有限公司 |
喹唑啉衍生物、其制备方法及用途
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
AR059066A1
(es)
*
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
|
|
PE20070978A1
(es)
*
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
|
GB0605120D0
(en)
|
2006-03-14 |
2006-04-26 |
Novartis Ag |
Organic Compounds
|
|
US20070231298A1
(en)
*
|
2006-03-31 |
2007-10-04 |
Cell Genesys, Inc. |
Cytokine-expressing cancer immunotherapy combinations
|
|
US20090098137A1
(en)
|
2006-04-05 |
2009-04-16 |
Novartis Ag |
Combinations of therapeutic agents for treating cancer
|
|
CA2644143C
(en)
|
2006-04-05 |
2013-10-01 |
Novartis Ag |
Combinations comprising bcr-abl/c-kit/pdgf-r tk inhibitors for treating cancer
|
|
AR060358A1
(es)
*
|
2006-04-06 |
2008-06-11 |
Novartis Vaccines & Diagnostic |
Quinazolinas para la inhibicion de pdk 1
|
|
AU2007240496A1
(en)
|
2006-04-19 |
2007-11-01 |
Novartis Ag |
Indazole compounds and methods for inhibition of CDC7
|
|
PE20080695A1
(es)
|
2006-04-27 |
2008-06-28 |
Banyu Pharma Co Ltd |
Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
|
|
NZ572299A
(en)
|
2006-05-09 |
2010-07-30 |
Novartis Ag |
Combination comprising a substituted 3,5-diphenyl-1,2,4-triazole and a platinum compound and use thereof
|
|
CN104706637A
(zh)
*
|
2006-05-18 |
2015-06-17 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
|
US20100279327A1
(en)
*
|
2006-06-12 |
2010-11-04 |
Bipar Sciences, Inc. |
Method of treating diseases with parp inhibitors
|
|
JP2010504079A
(ja)
*
|
2006-06-12 |
2010-02-12 |
バイパー サイエンシズ，インコーポレイティド |
Ｐａｒｐ阻害剤を用いる疾病の治療方法
|
|
JPWO2008001956A1
(ja)
*
|
2006-06-29 |
2009-12-03 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
肝線維症治療剤
|
|
JP2009542778A
(ja)
*
|
2006-07-13 |
2009-12-03 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
Ｍｔｋｉキナゾリン誘導体
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PL2383297T3
(pl)
|
2006-08-14 |
2013-06-28 |
Xencor Inc |
Zoptymalizowane przeciwciała ukierunkowane na CD19
|
|
WO2008026748A1
(en)
|
2006-08-28 |
2008-03-06 |
Eisai R & D Management Co., Ltd. |
Antitumor agent for undifferentiated gastric cancer
|
|
JP2008081492A
(ja)
|
2006-08-31 |
2008-04-10 |
Banyu Pharmaceut Co Ltd |
オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
|
|
WO2008030883A2
(en)
*
|
2006-09-05 |
2008-03-13 |
Bipar Sciences, Inc. |
Treatment of cancer
|
|
CN101534836B
(zh)
*
|
2006-09-05 |
2011-09-28 |
彼帕科学公司 |
Parp抑制剂在制备治疗肥胖症的药物中的用途
|
|
EP2061469B8
(en)
*
|
2006-09-11 |
2014-02-26 |
Curis, Inc. |
Quinazoline based egfr inhibitors
|
|
ES2372217T3
(es)
|
2006-09-12 |
2012-01-17 |
Genentech, Inc. |
Procedimientos y composiciones para el diagnóstico y tratamiento del cáncer de pulmón utilizando el gen de pdgfra, kit o kdr como marcador genético.
|
|
AU2007299080B2
(en)
|
2006-09-18 |
2013-04-18 |
Boehringer Ingelheim International Gmbh |
Method for treating cancer harboring EGFR mutations
|
|
WO2008037477A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as p13k lipid kinase inhibitors
|
|
WO2008044041A1
(en)
|
2006-10-12 |
2008-04-17 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
EP2073807A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
WO2008046242A1
(fr)
*
|
2006-10-16 |
2008-04-24 |
Institute Of Mataria Medica, Chinese Academy Of Medical Sciences |
Nouveaux dérivés quinazolines, leurs procédés de préparation et leurs utilisations
|
|
AU2007310842A1
(en)
*
|
2006-10-27 |
2008-05-02 |
Janssen Pharmaceutica Nv |
Use of a MT kinase inhibitor for treating or preventing brain cancer
|
|
US8586621B2
(en)
|
2006-10-27 |
2013-11-19 |
Michael A. Zeligs |
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
|
|
CL2007003158A1
(es)
|
2006-11-02 |
2008-05-16 |
Astrazeneca Ab |
Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion.
|
|
EP1921070A1
(de)
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
|
|
EP2125841A1
(en)
*
|
2006-12-13 |
2009-12-02 |
Gilead Sciences, Inc. |
Monophosphates as mutual prodrugs of anti-inflammatory signal transduction modulators (aistm's) and beta-agonists for the treatment of pulmonary inflammation and bronchoconstriction
|
|
AU2007338792B2
(en)
|
2006-12-20 |
2012-05-31 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
|
US7977336B2
(en)
|
2006-12-28 |
2011-07-12 |
Banyu Pharmaceutical Co. Ltd |
Aminopyrimidine derivatives as PLK1 inhibitors
|
|
AU2008205252B2
(en)
|
2007-01-09 |
2013-02-21 |
Amgen Inc. |
Bis-aryl amide derivatives useful for the treatment of cancer
|
|
CA2676796C
(en)
|
2007-01-29 |
2016-02-23 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of undifferentiated gastric cancer
|
|
AU2008212999A1
(en)
|
2007-02-06 |
2008-08-14 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
|
|
US20100069458A1
(en)
|
2007-02-15 |
2010-03-18 |
Peter Wisdom Atadja |
Combination of lbh589 with other therapeutic agents for treating cancer
|
|
MX2009008531A
(es)
|
2007-02-16 |
2009-08-26 |
Amgen Inc |
Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met.
|
|
SI2132573T1
(sl)
|
2007-03-02 |
2014-07-31 |
Genentech, Inc. |
Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3
|
|
WO2008121346A1
(en)
*
|
2007-03-30 |
2008-10-09 |
Massachusetts Institute Of Technology |
Methods for identifying compounds that modulate neurotrophic factor signaling
|
|
AU2008237749B2
(en)
|
2007-04-16 |
2013-01-17 |
Cipla Limited |
Process for the preparation of gefitinib
|
|
EP2176298B1
(en)
|
2007-05-30 |
2017-11-15 |
Xencor, Inc. |
Methods and compositions for inhibiting cd32b expressing cells
|
|
PL2171090T3
(pl)
|
2007-06-08 |
2013-09-30 |
Genentech Inc |
Markery ekspresji genów odporności guza na leczenie hamujące HER2
|
|
CA2687909C
(en)
*
|
2007-06-21 |
2015-09-15 |
Janssen Pharmaceutica Nv |
Indolin-2-ones and aza-indolin-2-ones
|
|
AU2008281849B2
(en)
|
2007-07-27 |
2013-11-28 |
Janssen Pharmaceutica Nv |
Pyrrolopyrimidines
|
|
CA2696164C
(en)
*
|
2007-08-13 |
2018-06-12 |
Vasgene Therapeutics, Inc. |
Cancer treatment using humanized antibodies that bind to ephb4
|
|
PL2188313T3
(pl)
|
2007-08-21 |
2018-04-30 |
Amgen, Inc. |
Białka wiążące ludzki antygen c-fms
|
|
WO2009035718A1
(en)
*
|
2007-09-10 |
2009-03-19 |
Curis, Inc. |
Tartrate salts or complexes of quinazoline based egfr inhibitors containing a zinc binding moiety
|
|
US8022216B2
(en)
|
2007-10-17 |
2011-09-20 |
Wyeth Llc |
Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
|
|
CN101903025A
(zh)
*
|
2007-10-19 |
2010-12-01 |
彼帕科学公司 |
利用苯并吡喃酮-型parp抑制剂治疗癌症的方法和组合物
|
|
WO2009052379A2
(en)
*
|
2007-10-19 |
2009-04-23 |
Pharma Mar, S.A. |
Improved antitumoral treatments
|
|
WO2009054332A1
(ja)
|
2007-10-23 |
2009-04-30 |
Banyu Pharmaceutical Co., Ltd. |
ピリドン置換ジヒドロピラゾロピリミジノン誘導体
|
|
US8080558B2
(en)
*
|
2007-10-29 |
2011-12-20 |
Natco Pharma Limited |
4-(tetrazol-5-yl)-quinazoline derivatives as anti-cancer agent
|
|
US8952035B2
(en)
|
2007-11-09 |
2015-02-10 |
Eisai R&D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
|
EP2217244A4
(en)
*
|
2007-11-12 |
2011-08-31 |
Bipar Sciences Inc |
TREATMENT OF NUTRITIONAL CANCER AND EGG CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTITUMOROUS MEDICINES
|
|
US7732491B2
(en)
*
|
2007-11-12 |
2010-06-08 |
Bipar Sciences, Inc. |
Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
|
|
WO2009067543A2
(en)
*
|
2007-11-19 |
2009-05-28 |
The Regents Of The University Of Colorado |
Treatment of histone deacetylase mediated disorders
|
|
CL2008003449A1
(es)
|
2007-11-21 |
2010-02-19 |
Imclone Llc |
Anticuerpo o fragmentos del mismo contra el receptor de proteína estimulante de macrófagos/ron; composición farmacéutica que lo comprende; uso para inhibir angiogénesis, crecimiento tumoral, proliferación, migración e invasión de células tumorales, activación de ron o fosforilación de mapk y/o akt; y uso para tratar cáncer.
|
|
RU2010128107A
(ru)
*
|
2007-12-07 |
2012-01-20 |
Байпар Сайенсиз, Инк. (Us) |
Лечение рака ингибиторами топоизомеразы в комбинации с ингибиторами parp
|
|
EP2240475B1
(en)
|
2007-12-20 |
2013-09-25 |
Novartis AG |
Thiazole derivatives used as pi 3 kinase inhibitors
|
|
CN101918374A
(zh)
*
|
2008-01-18 |
2010-12-15 |
纳特科制药有限公司 |
用于治疗癌症相关病症的6.7-二烷氧基喹唑啉衍生物
|
|
WO2009094216A1
(en)
|
2008-01-22 |
2009-07-30 |
Concert Pharmaceuticals Inc. |
Derivatives of gefitinib
|
|
KR101506062B1
(ko)
*
|
2008-01-29 |
2015-03-25 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
혈관 저해 물질과 탁산의 병용
|
|
EP2252315A1
(en)
*
|
2008-01-30 |
2010-11-24 |
Pharma Mar, S.A. |
Improved antitumoral treatments
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
|
|
US8497369B2
(en)
|
2008-02-07 |
2013-07-30 |
Boehringer Ingelheim International Gmbh |
Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
|
|
US20110033453A1
(en)
*
|
2008-03-05 |
2011-02-10 |
Carlos Garcia-Echeverria |
Use of pyrimidine derivatives for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
|
|
EP2262522A1
(en)
*
|
2008-03-07 |
2010-12-22 |
Pharma Mar, S.A. |
Improved antitumoral treatments
|
|
AU2009228765B2
(en)
|
2008-03-24 |
2012-05-31 |
Novartis Ag |
Arylsulfonamide-based matrix metalloprotease inhibitors
|
|
CN101544609A
(zh)
|
2008-03-25 |
2009-09-30 |
上海艾力斯医药科技有限公司 |
4-苯胺喹唑啉衍生物的结晶形式
|
|
GEP20125708B
(en)
|
2008-03-26 |
2012-12-10 |
Novartis Ag |
Hydroxamate-based inhibitors of deacetylases b
|
|
JP5739802B2
(ja)
|
2008-05-13 |
2015-06-24 |
アストラゼネカ アクチボラグ |
４−（３−クロロ−２−フルオロアニリノ）−７−メトキシ−６−｛［１−（ｎ−メチルカルバモイルメチル）ピペリジン−４−イル］オキシ｝キナゾリンのフマル酸塩
|
|
NZ589143A
(en)
|
2008-05-14 |
2012-02-24 |
Genomic Health Inc |
Colorectal cancer response prediction based on AREG EREG DUSP6 and SLC26A3 expression levels
|
|
CN101584696A
(zh)
|
2008-05-21 |
2009-11-25 |
上海艾力斯医药科技有限公司 |
包含喹唑啉衍生物的组合物及制备方法、用途
|
|
BRPI0914790A2
(pt)
|
2008-06-17 |
2015-10-20 |
Wyeth Llc |
uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma
|
|
DE102008031040A1
(de)
|
2008-06-30 |
2009-12-31 |
Alexander Priv.-Doz. Dr. Dömling |
Iressa zur Anwendung in der Organtransplantation
|
|
US8669273B2
(en)
|
2008-08-04 |
2014-03-11 |
Wyeth Llc |
Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
|
|
EP2313397B1
(de)
|
2008-08-08 |
2016-04-20 |
Boehringer Ingelheim International GmbH |
Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
|
|
CN101367793B
(zh)
*
|
2008-09-26 |
2013-09-11 |
中国科学院广州生物医药与健康研究院 |
一种具有抗肿瘤活性的氨基喹唑啉衍生物及其盐类
|
|
ES2704986T3
(es)
|
2008-10-16 |
2019-03-21 |
Celator Pharmaceuticals Inc |
Combinaciones de una camptotecina liposomal soluble en agua con cetuximab o bevacizumab
|
|
EP2349235A1
(en)
|
2008-11-07 |
2011-08-03 |
Triact Therapeutics, Inc. |
Use of catecholic butane derivatives in cancer therapy
|
|
WO2010065444A1
(en)
*
|
2008-12-01 |
2010-06-10 |
University Of Central Florida Research Foundation, Inc. |
Drug composition cytotoxic for pancreatic cancer cells
|
|
KR20110101159A
(ko)
|
2008-12-18 |
2011-09-15 |
노파르티스 아게 |
신규 염
|
|
US20120115840A1
(en)
|
2008-12-18 |
2012-05-10 |
Lech Ciszewski |
Hemifumarate salt of 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid
|
|
JP2012512884A
(ja)
|
2008-12-18 |
2012-06-07 |
ノバルティス アーゲー |
１−（４−｛１−［（ｅ）−４−シクロヘキシル−３−トリフルオロメチル−ベンジルオキシイミノ］−エチル｝−２−エチル−ベンジル）−アゼチジン−３−カルボン酸の新規の多形相
|
|
NZ779754A
(en)
|
2009-01-16 |
2023-04-28 |
Exelixis Inc |
Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl] oxy} phenyl)-n’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
|
|
WO2010083617A1
(en)
|
2009-01-21 |
2010-07-29 |
Oncalis Ag |
Pyrazolopyrimidines as protein kinase inhibitors
|
|
PL2391366T3
(pl)
|
2009-01-29 |
2013-04-30 |
Novartis Ag |
Podstawione benzimidazole do leczenia gwiaździaków
|
|
AU2010218781A1
(en)
|
2009-02-25 |
2011-07-28 |
Msd K.K. |
Pyrimidopyrimidoindazole derivative
|
|
WO2010099139A2
(en)
|
2009-02-25 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Combination anti-cancer therapy
|
|
JP2012519170A
(ja)
|
2009-02-26 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ，エルエルシー |
生体内の腫瘍細胞のｅｍｔステータスをモニターするためのｉｎｓｉｔｕ法
|
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010099364A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010101734A1
(en)
|
2009-03-06 |
2010-09-10 |
Merck Sharp & Dohme Corp. |
Combination cancer therapy with an akt inhibitor and other anticancer agents
|
|
EP2408479A1
(en)
|
2009-03-18 |
2012-01-25 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy comprising administration of an egfr inhibitor and an igf-1r inhibitor
|
|
MY152068A
(en)
|
2009-03-20 |
2014-08-15 |
Genentech Inc |
Bispecific anti-her antibodies
|
|
DK3000467T3
(da)
|
2009-04-06 |
2023-03-27 |
Wyeth Llc |
Behandling med neratinib mod brystkræft
|
|
US8530492B2
(en)
|
2009-04-17 |
2013-09-10 |
Nektar Therapeutics |
Oligomer-protein tyrosine kinase inhibitor conjugates
|
|
WO2010149755A1
(en)
|
2009-06-26 |
2010-12-29 |
Novartis Ag |
1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
|
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
|
PT2451445T
(pt)
|
2009-07-06 |
2019-07-10 |
Boehringer Ingelheim Int |
Processo para secagem de bibw2992, dos seus sais e de formulações farmacêuticas sólidas compreendendo este ingrediente ativo
|
|
US9050341B2
(en)
*
|
2009-07-14 |
2015-06-09 |
Natco Pharma Limited |
Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
|
EA201200260A1
(ru)
|
2009-08-12 |
2012-09-28 |
Новартис Аг |
Гетероциклические гидразоны и их применение для лечения рака и воспаления
|
|
NZ598220A
(en)
|
2009-08-17 |
2014-02-28 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
MY162940A
(en)
|
2009-08-19 |
2017-07-31 |
Eisai R&D Man Co Ltd |
Quinoline derivative-containing pharmaceutical composition
|
|
CA2771432A1
(en)
|
2009-08-20 |
2011-02-24 |
Novartis Ag |
Heterocyclic oxime compounds
|
|
IN2012DN01693A
(https=)
|
2009-08-26 |
2015-06-05 |
Novartis Ag |
|
|
CN102596963A
(zh)
|
2009-09-10 |
2012-07-18 |
诺瓦提斯公司 |
二环杂芳基的醚衍生物
|
|
EP2494070A2
(en)
|
2009-10-30 |
2012-09-05 |
Bristol-Myers Squibb Company |
Methods for treating cancer in patients having igf-1r inhibitor resistance
|
|
AU2010317167B2
(en)
|
2009-11-04 |
2012-11-29 |
Novartis Ag |
Heterocyclic sulfonamide derivatives useful as MEK inhibitors
|
|
US20110110942A1
(en)
|
2009-11-12 |
2011-05-12 |
Genentech, Inc. |
Method of promoting dendritic spine density
|
|
CA2780875A1
(en)
|
2009-11-13 |
2011-05-19 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
|
CN102781237A
(zh)
|
2009-11-23 |
2012-11-14 |
天蓝制药公司 |
用于传递治疗剂的基于环糊精的聚合物
|
|
WO2011064211A1
(en)
|
2009-11-25 |
2011-06-03 |
Novartis Ag |
Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
|
|
CN102770456B
(zh)
|
2009-12-04 |
2018-04-06 |
弗·哈夫曼-拉罗切有限公司 |
多特异性抗体、抗体类似物、组合物和方法
|
|
EA201200823A1
(ru)
|
2009-12-08 |
2013-02-28 |
Новартис Аг |
Гетероциклические производные сульфонамидов
|
|
CU24130B1
(es)
|
2009-12-22 |
2015-09-29 |
Novartis Ag |
Isoquinolinonas y quinazolinonas sustituidas
|
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
|
RU2012132278A
(ru)
|
2010-01-12 |
2014-02-20 |
Ф. Хоффманн-Ля Рош Аг |
Трициклические гетероциклические соединения, содержащие их композиции и способы их применения
|
|
US20110178287A1
(en)
|
2010-01-19 |
2011-07-21 |
Cerulean Pharma Inc. |
Cyclodextrin-based polymers for therapeutic delivery
|
|
CN102146060B
(zh)
*
|
2010-02-09 |
2013-07-03 |
陕西师范大学 |
制备吉非替尼及其中间体的方法
|
|
US9556249B2
(en)
|
2010-02-18 |
2017-01-31 |
Genentech, Inc. |
Neuregulin antagonists and use thereof in treating cancer
|
|
AU2011222867B2
(en)
|
2010-03-04 |
2014-03-06 |
Annika Algars |
Method for selecting patients for treatment with an EGFR inhibitor
|
|
US20130096104A1
(en)
|
2010-03-17 |
2013-04-18 |
Genentech, Inc. |
Imidazopyridine compounds, compositions and methods of use
|
|
WO2011119995A2
(en)
|
2010-03-26 |
2011-09-29 |
Cerulean Pharma Inc. |
Formulations and methods of use
|
|
JP2013528357A
(ja)
|
2010-03-29 |
2013-07-11 |
ザイムワークス，インコーポレイテッド |
強化又は抑制されたエフェクター機能を有する抗体
|
|
TWI406853B
(zh)
*
|
2010-04-07 |
2013-09-01 |
Dev Center Biotechnology |
Ｅｇｆｒ與ｖｅｇｆｒ－２雙重抑制劑及其用途與製法
|
|
WO2011130654A1
(en)
|
2010-04-16 |
2011-10-20 |
Genentech, Inc. |
Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
JP2013528635A
(ja)
|
2010-06-17 |
2013-07-11 |
ノバルティス アーゲー |
ビフェニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
|
|
WO2011157793A1
(en)
|
2010-06-17 |
2011-12-22 |
Novartis Ag |
Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
|
|
WO2011161217A2
(en)
|
2010-06-23 |
2011-12-29 |
Palacký University in Olomouc |
Targeting of vegfr2
|
|
CN102958523B
(zh)
|
2010-06-25 |
2014-11-19 |
卫材R&D管理有限公司 |
使用具有激酶抑制作用的组合的抗肿瘤剂
|
|
UA112517C2
(uk)
|
2010-07-06 |
2016-09-26 |
Новартіс Аг |
Тетрагідропіридопіримідинові похідні
|
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
|
MX2013002084A
(es)
|
2010-08-31 |
2013-05-09 |
Genentech Inc |
Biomarcadores y metodos de tratamiento.
|
|
TW201217387A
(en)
|
2010-09-15 |
2012-05-01 |
Hoffmann La Roche |
Azabenzothiazole compounds, compositions and methods of use
|
|
JP2013537210A
(ja)
|
2010-09-16 |
2013-09-30 |
ノバルティス アーゲー |
１７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
|
|
EP3323818A1
(en)
|
2010-09-22 |
2018-05-23 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
EP2637692A4
(en)
|
2010-11-12 |
2014-09-10 |
Scott & White Healthcare |
ANTIBODIES TO THE ENDOTHELIAL TUMOR MARKER 8
|
|
BR112013011520A2
(pt)
|
2010-11-19 |
2019-09-24 |
Hoffmann La Roche |
pirazolo piridinas e pirazolo piridinas e seu uso como inibidores de tyk2
|
|
AU2011333738A1
(en)
|
2010-11-24 |
2013-07-11 |
Glaxo Group Limited |
Multispecific antigen binding proteins targeting HGF
|
|
WO2012085815A1
(en)
|
2010-12-21 |
2012-06-28 |
Novartis Ag |
Bi-heteroaryl compounds as vps34 inhibitors
|
|
EP2468883A1
(en)
|
2010-12-22 |
2012-06-27 |
Pangaea Biotech S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
|
WO2012085176A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
|
|
US9134297B2
(en)
|
2011-01-11 |
2015-09-15 |
Icahn School Of Medicine At Mount Sinai |
Method and compositions for treating cancer and related methods
|
|
MX343706B
(es)
|
2011-01-31 |
2016-11-18 |
Novartis Ag |
Derivados heterocíclicos novedosos.
|
|
EP2673277A1
(en)
|
2011-02-10 |
2013-12-18 |
Novartis AG |
[1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
|
EP2492688A1
(en)
|
2011-02-23 |
2012-08-29 |
Pangaea Biotech, S.A. |
Molecular biomarkers for predicting response to antitumor treatment in lung cancer
|
|
WO2012122058A2
(en)
|
2011-03-04 |
2012-09-13 |
Newgen Therapeutics, Inc. |
Alkyne substituted quinazoline compound and methods of use
|
|
JP2014507465A
(ja)
|
2011-03-08 |
2014-03-27 |
ノバルティス アーゲー |
フルオロフェニル二環式ヘテロアリール化合物
|
|
AU2012225246B2
(en)
|
2011-03-10 |
2016-01-21 |
Omeros Corporation |
Generation of anti-FN14 monoclonal antibodies by ex-vivo accelerated antibody evolution
|
|
WO2012125904A1
(en)
|
2011-03-17 |
2012-09-20 |
The Trustees Of The University Of Pennsylvania |
Mutation mimicking compounds that bind to the kinase domain of egfr
|
|
EP2685980B1
(en)
|
2011-03-17 |
2017-12-06 |
The Trustees Of The University Of Pennsylvania |
Methods and use of bifunctional enzyme-building clamp-shaped molecules
|
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
|
EP2937349B1
(en)
|
2011-03-23 |
2016-12-28 |
Amgen Inc. |
Fused tricyclic dual inhibitors of cdk 4/6 and flt3
|
|
CN103402519B
(zh)
|
2011-04-18 |
2015-11-25 |
卫材R&D管理有限公司 |
肿瘤治疗剂
|
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
|
GB201106870D0
(en)
|
2011-04-26 |
2011-06-01 |
Univ Belfast |
Marker
|
|
US9029399B2
(en)
|
2011-04-28 |
2015-05-12 |
Novartis Ag |
17α-hydroxylase/C17,20-lyase inhibitors
|
|
WO2012155339A1
(zh)
|
2011-05-17 |
2012-11-22 |
江苏康缘药业股份有限公司 |
4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
|
|
JP6038128B2
(ja)
|
2011-06-03 |
2016-12-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
|
|
EA201391820A1
(ru)
|
2011-06-09 |
2014-12-30 |
Новартис Аг |
Гетероциклические сульфонамидные производные
|
|
US8859586B2
(en)
|
2011-06-20 |
2014-10-14 |
Novartis Ag |
Cyclohexyl isoquinolinone compounds
|
|
WO2012175520A1
(en)
|
2011-06-20 |
2012-12-27 |
Novartis Ag |
Hydroxy substituted isoquinolinone derivatives
|
|
KR20140025530A
(ko)
|
2011-06-27 |
2014-03-04 |
노파르티스 아게 |
테트라히드로-피리도-피리미딘 유도체의 고체 형태 및 염
|
|
AR086823A1
(es)
|
2011-06-30 |
2014-01-22 |
Genentech Inc |
Formulaciones de anticuerpo anti-c-met, metodos
|
|
WO2013007765A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Fused tricyclic compounds for use as inhibitors of janus kinases
|
|
WO2013007768A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
|
|
KR20140047160A
(ko)
|
2011-08-12 |
2014-04-21 |
에프. 호프만-라 로슈 아게 |
인다졸 화합물, 조성물 및 사용 방법
|
|
WO2013025446A2
(en)
|
2011-08-12 |
2013-02-21 |
Omeros Corporation |
Anti-fzd10 monoclonal antibodies and methods for their use
|
|
WO2013025939A2
(en)
|
2011-08-16 |
2013-02-21 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
|
EP3795145A3
(en)
|
2011-08-17 |
2021-06-09 |
Dennis M. Brown |
Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dibromodulcitol
|
|
MX2014001766A
(es)
|
2011-08-17 |
2014-05-01 |
Genentech Inc |
Anticuerpos de neuregulina y sus usos.
|
|
EP2751285B2
(en)
|
2011-08-31 |
2020-04-01 |
Genentech, Inc. |
Method for sensitivity testing of a tumour for a egfr kinase inhibitor
|
|
CA2848809A1
(en)
|
2011-09-15 |
2013-03-21 |
Novartis Ag |
6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
|
|
CN103827115A
(zh)
|
2011-09-20 |
2014-05-28 |
弗·哈夫曼-拉罗切有限公司 |
咪唑并吡啶化合物、组合物和使用方法
|
|
CN103012290B
(zh)
*
|
2011-09-28 |
2015-05-13 |
齐鲁制药有限公司 |
一种高纯度吉非替尼的制备方法
|
|
EP2761025A1
(en)
|
2011-09-30 |
2014-08-06 |
Genentech, Inc. |
Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells
|
|
EP2766497A1
(en)
|
2011-10-13 |
2014-08-20 |
Bristol-Myers Squibb Company |
Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors
|
|
PT2771342T
(pt)
|
2011-10-28 |
2016-08-17 |
Novartis Ag |
Derivados de purina e o seu uso no tratamento de doença
|
|
CN103102345B
(zh)
*
|
2011-11-14 |
2015-06-03 |
广东东阳光药业有限公司 |
氨基喹唑啉类衍生物及其盐和使用方法
|
|
AR092289A1
(es)
*
|
2011-11-14 |
2015-04-15 |
Sunshine Lake Pharma Co Ltd |
Derivados de aminoquinazolina y sus sales y metodos de uso
|
|
CN103102342B
(zh)
*
|
2011-11-14 |
2014-10-29 |
广东东阳光药业有限公司 |
氨基喹唑啉类衍生物及其盐和使用方法
|
|
WO2013080141A1
(en)
|
2011-11-29 |
2013-06-06 |
Novartis Ag |
Pyrazolopyrrolidine compounds
|
|
BR112014012979A2
(pt)
|
2011-11-30 |
2020-10-20 |
Genentech, Inc. |
mutações erbb3 em câncer
|
|
US9408885B2
(en)
|
2011-12-01 |
2016-08-09 |
Vib Vzw |
Combinations of therapeutic agents for treating melanoma
|
|
CN103130729B
(zh)
*
|
2011-12-05 |
2015-07-15 |
齐鲁制药有限公司 |
一种4-氯代-7-甲氧基喹唑啉-6-醇乙酸酯的制备方法
|
|
CN103172576B
(zh)
*
|
2011-12-21 |
2015-08-05 |
沈阳药科大学 |
吉非替尼的苹果酸加成盐及其制备和应用
|
|
JO3398B1
(ar)
|
2011-12-22 |
2019-10-20 |
Novartis Ag |
مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي
|
|
EP2794594A1
(en)
|
2011-12-22 |
2014-10-29 |
Novartis AG |
Quinoline derivatives
|
|
BR112014015308A8
(pt)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compostos para inibição da interação de bcl2 com contrapartes de ligação
|
|
WO2013096051A1
(en)
|
2011-12-23 |
2013-06-27 |
Novartis Ag |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
|
US9126980B2
(en)
|
2011-12-23 |
2015-09-08 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
|
EP2794591A1
(en)
|
2011-12-23 |
2014-10-29 |
Novartis AG |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
|
EP2794592A1
(en)
|
2011-12-23 |
2014-10-29 |
Novartis AG |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
|
US20130178520A1
(en)
|
2011-12-23 |
2013-07-11 |
Duke University |
Methods of treatment using arylcyclopropylamine compounds
|
|
UY34591A
(es)
|
2012-01-26 |
2013-09-02 |
Novartis Ag |
Compuestos de imidazopirrolidinona
|
|
WO2013113796A1
(en)
|
2012-01-31 |
2013-08-08 |
Smithkline Beecham (Cork) Limited |
Method of treating cancer
|
|
AU2013229786B2
(en)
|
2012-03-08 |
2017-06-22 |
Halozyme, Inc. |
Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
EP2752413B1
(en)
|
2012-03-26 |
2016-03-23 |
Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences |
Quinazoline derivative and application thereof
|
|
US20130259867A1
(en)
|
2012-03-27 |
2013-10-03 |
Genentech, Inc. |
Diagnosis and treatments relating to her3 inhibitors
|
|
AU2013243097A1
(en)
|
2012-04-03 |
2014-10-09 |
Novartis Ag |
Combination products with tyrosine kinase inhibitors and their use
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
WO2013173283A1
(en)
|
2012-05-16 |
2013-11-21 |
Novartis Ag |
Dosage regimen for a pi-3 kinase inhibitor
|
|
EP2855483B1
(en)
|
2012-05-24 |
2017-10-25 |
Novartis AG |
Pyrrolopyrrolidinone compounds
|
|
KR101457453B1
(ko)
*
|
2012-05-31 |
2014-11-04 |
주식회사 종근당 |
게피티닙의 제조방법 및 이의 제조에 사용되는 중간체
|
|
EP2861256B1
(en)
|
2012-06-15 |
2019-10-23 |
The Brigham and Women's Hospital, Inc. |
Compositions for treating cancer and methods for making the same
|
|
WO2013190089A1
(en)
|
2012-06-21 |
2013-12-27 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting outcome in lung cancer
|
|
WO2014016848A2
(en)
|
2012-07-24 |
2014-01-30 |
Laurus Labs Private Limited |
Solid forms of tyrosine kinase inhibitors, process for the preparation and their pharmaceutical composition thereof
|
|
WO2014025395A1
(en)
|
2012-08-06 |
2014-02-13 |
Duke University |
Compounds and methods for targeting hsp90
|
|
EP2890696A1
(en)
|
2012-08-29 |
2015-07-08 |
Amgen, Inc. |
Quinazolinone compounds and derivatives thereof
|
|
JP6374392B2
(ja)
|
2012-11-05 |
2018-08-15 |
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド |
Ｘｂｐ１、ｃｄ１３８およびｃｓ１ペプチド、該ペプチドを含有する薬学的組成物、ならびにかかるペプチドおよび組成物を使用する方法
|
|
TW201422625A
(zh)
|
2012-11-26 |
2014-06-16 |
Novartis Ag |
二氫－吡啶并－□衍生物之固體形式
|
|
KR20150098605A
(ko)
|
2012-12-21 |
2015-08-28 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
퀴놀린 유도체의 비정질 형태 및 그의 제조방법
|
|
CN103073509A
(zh)
*
|
2012-12-31 |
2013-05-01 |
广东先强药业有限公司 |
一类喹唑啉衍生物的制备方法
|
|
CN103910690A
(zh)
*
|
2013-01-06 |
2014-07-09 |
上海科胜药物研发有限公司 |
一种吉非替尼新晶型及其制备方法
|
|
US20150329524A1
(en)
|
2013-01-10 |
2015-11-19 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Fatty acid synthase inhibitors
|
|
US9556180B2
(en)
|
2013-01-22 |
2017-01-31 |
Novartis Ag |
Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
|
|
WO2014115077A1
(en)
|
2013-01-22 |
2014-07-31 |
Novartis Ag |
Substituted purinone compounds
|
|
WO2014120995A2
(en)
|
2013-02-01 |
2014-08-07 |
Wellstat Therapeutics Corporation |
Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity
|
|
JP6647868B2
(ja)
|
2013-02-20 |
2020-02-14 |
ノバルティス アーゲー |
ヒト化抗ＥＧＦＲｖＩＩＩキメラ抗原受容体を用いたがんの処置
|
|
WO2014128612A1
(en)
|
2013-02-20 |
2014-08-28 |
Novartis Ag |
Quinazolin-4-one derivatives
|
|
JP2016509045A
(ja)
|
2013-02-22 |
2016-03-24 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
がんを治療し、薬剤耐性を防止する方法
|
|
US9834575B2
(en)
|
2013-02-26 |
2017-12-05 |
Triact Therapeutics, Inc. |
Cancer therapy
|
|
US9468681B2
(en)
|
2013-03-01 |
2016-10-18 |
California Institute Of Technology |
Targeted nanoparticles
|
|
EP2964638B1
(en)
|
2013-03-06 |
2017-08-09 |
Astrazeneca AB |
Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor
|
|
MX2015011428A
(es)
|
2013-03-06 |
2016-02-03 |
Genentech Inc |
Metodos para tratar y prevenir la resistencia a los farmacos para el cancer.
|
|
KR20150130491A
(ko)
|
2013-03-13 |
2015-11-23 |
제넨테크, 인크. |
피라졸로 화합물 및 그것의 용도
|
|
JP2016516046A
(ja)
|
2013-03-14 |
2016-06-02 |
ジェネンテック， インコーポレイテッド |
がんの治療方法及びがん薬物耐性を阻止する方法
|
|
MX2015010854A
(es)
|
2013-03-14 |
2016-07-20 |
Genentech Inc |
Combinaciones de un compuesto inhibidor de mek con un compuesto inhibidor de her3/egfr y metodos de uso.
|
|
MX394360B
(es)
|
2013-03-14 |
2025-03-24 |
Sumitomo Pharma Oncology Inc |
Inhibidores de jak2 y alk2 y metodos para su uso.
|
|
EP2968340A4
(en)
|
2013-03-15 |
2016-08-10 |
Intellikine Llc |
COMBINING KINASE INHIBITORS AND USES THEREOF
|
|
CA2905123A1
(en)
|
2013-03-15 |
2014-09-18 |
Genentech, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
EP2976085A1
(en)
|
2013-03-21 |
2016-01-27 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression
|
|
WO2014147631A1
(en)
|
2013-03-22 |
2014-09-25 |
Natco Pharma Limited |
Formulation comprising gefitinib as oral suspension
|
|
WO2014155268A2
(en)
|
2013-03-25 |
2014-10-02 |
Novartis Ag |
Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
|
|
NZ714049A
(en)
|
2013-05-14 |
2020-05-29 |
Eisai R&D Man Co Ltd |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
US20150018376A1
(en)
|
2013-05-17 |
2015-01-15 |
Novartis Ag |
Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
|
|
CN103304491A
(zh)
*
|
2013-06-17 |
2013-09-18 |
连云港盛和生物科技有限公司 |
一种吉非替尼的制备方法
|
|
KR20150001936A
(ko)
*
|
2013-06-28 |
2015-01-07 |
제일약품주식회사 |
게피티닙의 신규한 결정형 및 이의 제조방법
|
|
UY35675A
(es)
|
2013-07-24 |
2015-02-27 |
Novartis Ag |
Derivados sustituidos de quinazolin-4-ona
|
|
EP3027623A4
(en)
*
|
2013-08-02 |
2017-03-01 |
Ignyta, Inc. |
METHODS OF TREATING VARIOUS CANCERS USING AN AXL/cMET INHIBITOR ALONE OR IN COMBINATION WITH OTHER AGENTS
|
|
WO2015022664A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
|
WO2015022663A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
|
EP3041474B1
(en)
|
2013-09-05 |
2020-03-18 |
Genentech, Inc. |
Antiproliferative compounds
|
|
WO2015035410A1
(en)
|
2013-09-09 |
2015-03-12 |
Triact Therapeutic, Inc. |
Cancer therapy
|
|
JP6282745B2
(ja)
|
2013-09-12 |
2018-02-21 |
ハロザイム インコーポレイテッド |
修飾抗上皮成長因子受容体抗体およびその使用法
|
|
BR112015032713B1
(pt)
|
2013-09-17 |
2023-03-21 |
Obi Pharma, Inc |
Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto
|
|
KR20160060100A
(ko)
|
2013-09-22 |
2016-05-27 |
칼리토르 사이언시즈, 엘엘씨 |
치환된 아미노피리미딘 화합물 및 이용 방법
|
|
CN104513253A
(zh)
*
|
2013-10-01 |
2015-04-15 |
南京波尔泰药业科技有限公司 |
用于治疗增殖性疾病的大环化合物
|
|
TW201605857A
(zh)
|
2013-10-03 |
2016-02-16 |
赫孚孟拉羅股份公司 |
Ｃｄｋ８之醫療性抑制劑及其用途
|
|
BR112016008477A2
(pt)
|
2013-10-18 |
2017-10-03 |
Genentech Inc |
Corpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica e usos do anticorpo
|
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
|
|
CN105979947A
(zh)
|
2013-12-06 |
2016-09-28 |
诺华股份有限公司 |
α-同工型选择性磷脂酰肌醇3-激酶抑制剂的剂量方案
|
|
WO2015095423A2
(en)
|
2013-12-17 |
2015-06-25 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
JP2017507900A
(ja)
|
2013-12-17 |
2017-03-23 |
ジェネンテック， インコーポレイテッド |
Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法
|
|
US9242965B2
(en)
|
2013-12-31 |
2016-01-26 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
|
|
US20160361309A1
(en)
|
2014-02-26 |
2016-12-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Methods of treating cancer patients responding to ezh2 inhibitor gsk126
|
|
RU2016141385A
(ru)
|
2014-03-24 |
2018-04-28 |
Дженентек, Инк. |
Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
|
|
US10000469B2
(en)
|
2014-03-25 |
2018-06-19 |
Duke University |
Heat shock protein 70 (hsp-70) receptor ligands
|
|
WO2015145388A2
(en)
|
2014-03-27 |
2015-10-01 |
Novartis Ag |
Methods of treating colorectal cancers harboring upstream wnt pathway mutations
|
|
WO2015148867A1
(en)
|
2014-03-28 |
2015-10-01 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
KR20160146747A
(ko)
|
2014-03-31 |
2016-12-21 |
제넨테크, 인크. |
항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법
|
|
SG11201607969XA
(en)
|
2014-03-31 |
2016-10-28 |
Genentech Inc |
Anti-ox40 antibodies and methods of use
|
|
BR112016022499A2
(pt)
|
2014-04-03 |
2017-08-15 |
Invictus Oncology Pvt Ltd |
Produtos terapêuticos combinatórios supramoleculares
|
|
WO2015156674A2
(en)
|
2014-04-10 |
2015-10-15 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
WO2015170345A1
(en)
|
2014-05-09 |
2015-11-12 |
Council Of Scientific & Industrial Research |
Pharmaceutical cocrystals of gefitinib
|
|
RU2577518C2
(ru)
*
|
2014-06-02 |
2016-03-20 |
Олег Ростиславович Михайлов |
КРИСТАЛЛИЧЕСКАЯ БЕЗВОДНАЯ γ-МОДИФИКАЦИЯ 4-(3'-ХЛОР-4'-ФТОРАНИЛИНО)-7-МЕТОКСИ-6-(3-МОРФОЛИНОПРОПОКСИ)ХИНАЗОЛИНА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ
|
|
US9617227B2
(en)
|
2014-06-10 |
2017-04-11 |
Scinopharm (Changshu) Pharmaceuticals, Ltd. |
Process of preparing a quinazoline derivative
|
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
|
CA2954862A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Combination therapy
|
|
PT3524595T
(pt)
|
2014-08-28 |
2022-09-19 |
Eisai R&D Man Co Ltd |
Derivado de quinolina altamente puro e método para produção do mesmo
|
|
CN107074823B
(zh)
|
2014-09-05 |
2021-05-04 |
基因泰克公司 |
治疗性化合物及其用途
|
|
TWI567063B
(zh)
*
|
2014-09-05 |
2017-01-21 |
國立交通大學 |
用於促進癌細胞凋亡的化合物、其醫藥組成物及其用途
|
|
EP3193866A1
(en)
|
2014-09-19 |
2017-07-26 |
Genentech, Inc. |
Use of cbp/ep300 and bet inhibitors for treatment of cancer
|
|
CN107912040B
(zh)
|
2014-10-10 |
2021-04-06 |
基因泰克公司 |
作为组蛋白脱甲基酶抑制剂的吡咯烷酰胺化合物
|
|
US20170252335A1
(en)
|
2014-10-17 |
2017-09-07 |
Novartis Ag |
Combination of Ceritinib with an EGFR Inhibitor
|
|
WO2016073380A1
(en)
|
2014-11-03 |
2016-05-12 |
Genentech, Inc. |
Method and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment
|
|
CA2966523A1
(en)
|
2014-11-03 |
2016-05-12 |
Genentech, Inc. |
Assays for detecting t cell immune subsets and methods of use thereof
|
|
US20160152720A1
(en)
|
2014-11-06 |
2016-06-02 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
MA40940A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
CN107108613B
(zh)
|
2014-11-10 |
2020-02-25 |
基因泰克公司 |
布罗莫结构域抑制剂及其用途
|
|
MA40943A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
SG10201807625PA
(en)
|
2014-11-17 |
2018-10-30 |
Genentech Inc |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
EP3632915A1
(en)
|
2014-11-27 |
2020-04-08 |
Genentech, Inc. |
4,5,6,7-tetrahydro-1 h-pyrazolo[4,3-c]pyridin-3-amine compounds as cbp and/or ep300 inhibitors
|
|
EP3228650B1
(en)
*
|
2014-12-04 |
2022-03-09 |
Delta-Fly Pharma, Inc. |
Novel peg derivative
|
|
US20180000827A1
(en)
|
2014-12-19 |
2018-01-04 |
Synthon B.V. |
Pharmaceutical composition comprising gefitinib
|
|
KR20170094165A
(ko)
|
2014-12-23 |
2017-08-17 |
제넨테크, 인크. |
화학요법-내성 암을 치료 및 진단하는 조성물 및 방법
|
|
WO2016105503A1
(en)
|
2014-12-24 |
2016-06-30 |
Genentech, Inc. |
Therapeutic, diagnostic and prognostic methods for cancer of the bladder
|
|
JP2018503373A
(ja)
|
2014-12-30 |
2018-02-08 |
ジェネンテック， インコーポレイテッド |
がんの予後診断及び治療のための方法及び組成物
|
|
PL3242666T3
(pl)
|
2015-01-06 |
2025-02-17 |
Arena Pharmaceuticals, Inc. |
Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
|
|
HK1247955A1
(zh)
|
2015-01-08 |
2018-10-05 |
小利兰.斯坦福大学托管委员会 |
提供骨、骨髓及软骨的诱导的因子和细胞
|
|
EP3242872B1
(en)
|
2015-01-09 |
2019-07-03 |
Genentech, Inc. |
(piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer
|
|
WO2016112251A1
(en)
|
2015-01-09 |
2016-07-14 |
Genentech, Inc. |
4,5-dihydroimidazole derivatives and their use as histone demethylase (kdm2b) inhibitors
|
|
EP3242874B1
(en)
|
2015-01-09 |
2018-10-31 |
Genentech, Inc. |
Pyridazinone derivatives and their use in the treatment of cancer
|
|
KR101635724B1
(ko)
*
|
2015-01-28 |
2016-07-05 |
일동제약주식회사 |
게피티닙의 개선된 제조방법
|
|
MA41414A
(fr)
|
2015-01-28 |
2017-12-05 |
Centre Nat Rech Scient |
Protéines de liaison agonistes d' icos
|
|
EP3250571B1
(en)
|
2015-01-29 |
2022-11-30 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
WO2016123387A1
(en)
|
2015-01-30 |
2016-08-04 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
MA41598A
(fr)
|
2015-02-25 |
2018-01-02 |
Constellation Pharmaceuticals Inc |
Composés thérapeutiques de pyridazine et leurs utilisations
|
|
LT3263106T
(lt)
|
2015-02-25 |
2024-01-10 |
Eisai R&D Management Co., Ltd. |
Chinolino darinių kartumo sumažinimo būdas
|
|
KR102662228B1
(ko)
|
2015-03-04 |
2024-05-02 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
WO2016150340A1
(zh)
*
|
2015-03-20 |
2016-09-29 |
正大天晴药业集团股份有限公司 |
喹唑啉衍生物的盐及其制备方法
|
|
KR20180002653A
(ko)
|
2015-04-07 |
2018-01-08 |
제넨테크, 인크. |
효능작용 활성을 갖는 항원 결합 복합체 및 사용 방법
|
|
ES2835866T5
(es)
|
2015-05-12 |
2024-12-02 |
Hoffmann La Roche |
Procedimientos terapéuticos y de diagnóstico para el cáncer
|
|
ES2789500T5
(es)
|
2015-05-29 |
2023-09-20 |
Hoffmann La Roche |
Procedimientos terapéuticos y de diagnóstico para el cáncer
|
|
JP2018521019A
(ja)
|
2015-06-08 |
2018-08-02 |
ジェネンテック， インコーポレイテッド |
抗ｏｘ４０抗体を使用して癌を治療する方法
|
|
MX2017015937A
(es)
|
2015-06-08 |
2018-12-11 |
Genentech Inc |
Métodos de tratamiento del cáncer con anticuerpos anti-ox40 y antagonistas de unión al eje de pd-1.
|
|
MX373231B
(es)
|
2015-06-16 |
2020-05-08 |
Eisai R&D Man Co Ltd |
Agente anticancerigeno.
|
|
KR102689256B1
(ko)
|
2015-06-17 |
2024-07-30 |
제넨테크, 인크. |
Pd-1 축 결합 길항제 및 탁산을 사용하여 국소적 진행성 또는 전이성 유방암을 치료하는 방법
|
|
BR112017027656B1
(pt)
|
2015-06-22 |
2023-12-05 |
Arena Pharmaceuticals, Inc. |
Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
|
|
ES2882255T3
(es)
|
2015-07-01 |
2021-12-01 |
California Inst Of Techn |
Sistemas de administración basados en polímeros de ácido múcico catiónicos
|
|
US20180230431A1
(en)
|
2015-08-07 |
2018-08-16 |
Glaxosmithkline Intellectual Property Development Limited |
Combination Therapy
|
|
US12220398B2
(en)
|
2015-08-20 |
2025-02-11 |
Eisai R&D Management Co., Ltd. |
Tumor therapeutic agent
|
|
ES2862727T3
(es)
|
2015-08-26 |
2021-10-07 |
Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio |
Compuestos tricíclicos condensados como inhibidores de proteínas quinasas
|
|
US10935544B2
(en)
|
2015-09-04 |
2021-03-02 |
Obi Pharma, Inc. |
Glycan arrays and method of use
|
|
JP2018527362A
(ja)
|
2015-09-11 |
2018-09-20 |
サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． |
置換されたヘテロアリール化合物および使用方法
|
|
GB201516905D0
(en)
|
2015-09-24 |
2015-11-11 |
Stratified Medical Ltd |
Treatment of Neurodegenerative diseases
|
|
PE20181046A1
(es)
|
2015-09-25 |
2018-07-03 |
Genentech Inc |
Anticuerpos anti-tigit y metodos de uso
|
|
CN105250228B
(zh)
*
|
2015-10-12 |
2017-10-24 |
山东罗欣药业集团股份有限公司 |
一种吉非替尼的片剂及其原料的制备方法
|
|
RU2018119085A
(ru)
|
2015-11-02 |
2019-12-04 |
Новартис Аг |
Схема введения ингибитора фосфатидилинозитол-3-киназы
|
|
JP2019505476A
(ja)
|
2015-12-01 |
2019-02-28 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ |
組合せ処置およびその方法
|
|
MY196817A
(en)
|
2015-12-16 |
2023-05-03 |
Genentech Inc |
Process for the preparation of tricyclic pi3k inhibitor compounds and methods for using the same for the treatment of cancer
|
|
ES2851499T3
(es)
|
2015-12-30 |
2021-09-07 |
Synthon Bv |
Proceso para fabricar una forma cristalina de gefitinib
|
|
CN105503748A
(zh)
*
|
2015-12-31 |
2016-04-20 |
哈药集团技术中心 |
一种吉非替尼的制备方法
|
|
KR20180097615A
(ko)
|
2016-01-08 |
2018-08-31 |
에프. 호프만-라 로슈 아게 |
Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법
|
|
JP6821693B2
(ja)
|
2016-02-29 |
2021-01-27 |
ジェネンテック， インコーポレイテッド |
がんのための治療方法及び診断方法
|
|
BR112018070097A2
(pt)
|
2016-03-29 |
2019-02-12 |
Obi Pharma, Inc. |
anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos
|
|
US10980894B2
(en)
|
2016-03-29 |
2021-04-20 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
|
EP3865511A1
(en)
|
2016-04-14 |
2021-08-18 |
F. Hoffmann-La Roche AG |
Anti-rspo3 antibodies and methods of use
|
|
KR20190003958A
(ko)
|
2016-04-15 |
2019-01-10 |
제넨테크, 인크. |
암의 치료 및 모니터링 방법
|
|
KR20180134347A
(ko)
|
2016-04-15 |
2018-12-18 |
제넨테크, 인크. |
암의 진단 및 치료 방법
|
|
MX2018012493A
(es)
|
2016-04-15 |
2019-06-06 |
Genentech Inc |
Métodos para controlar y tratar el cáncer.
|
|
KR20230110820A
(ko)
|
2016-04-22 |
2023-07-25 |
오비아이 파머 인코퍼레이티드 |
글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에의한 암 면역요법
|
|
US11261187B2
(en)
|
2016-04-22 |
2022-03-01 |
Duke University |
Compounds and methods for targeting HSP90
|
|
US20190151346A1
(en)
|
2016-05-10 |
2019-05-23 |
INSERM (Institute National de la Santé et de la Recherche Médicale) |
Combinations therapies for the treatment of cancer
|
|
KR101796684B1
(ko)
*
|
2016-05-19 |
2017-11-10 |
건국대학교 산학협력단 |
케라틴 8 인산화 억제제를 포함하는 황반변성 예방 또는 치료용 약학 조성물 및 황반변성 치료제의 스크리닝 방법
|
|
EP3464270B1
(en)
|
2016-05-24 |
2022-02-23 |
Genentech, Inc. |
Heterocyclic inhibitors of cbp/ep300 and their use in the treatment of cancer
|
|
JP7014736B2
(ja)
|
2016-05-24 |
2022-02-01 |
ジェネンテック， インコーポレイテッド |
がんの処置のためのピラゾロピリジン誘導体
|
|
CN106045980B
(zh)
*
|
2016-06-03 |
2017-11-03 |
江苏开放大学 |
一种喹唑啉衍生物及其制备方法
|
|
US20200129519A1
(en)
|
2016-06-08 |
2020-04-30 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
WO2017214452A1
(en)
|
2016-06-08 |
2017-12-14 |
Xencor, Inc. |
Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b
|
|
CN110072545A
(zh)
|
2016-07-27 |
2019-07-30 |
台湾浩鼎生技股份有限公司 |
免疫原性/治疗性聚糖组合物及其用途
|
|
US11643456B2
(en)
|
2016-07-29 |
2023-05-09 |
Obi Pharma, Inc. |
Human antibodies, pharmaceutical compositions and methods
|
|
EP3494140A1
(en)
|
2016-08-04 |
2019-06-12 |
GlaxoSmithKline Intellectual Property Development Ltd |
Anti-icos and anti-pd-1 antibody combination therapy
|
|
WO2018027204A1
(en)
|
2016-08-05 |
2018-02-08 |
Genentech, Inc. |
Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
|
|
WO2018029124A1
(en)
|
2016-08-08 |
2018-02-15 |
F. Hoffmann-La Roche Ag |
Therapeutic and diagnostic methods for cancer
|
|
WO2018039203A1
(en)
|
2016-08-23 |
2018-03-01 |
Oncopep, Inc. |
Peptide vaccines and durvalumab for treating multiple myeloma
|
|
WO2018039205A1
(en)
|
2016-08-23 |
2018-03-01 |
Oncopep, Inc. |
Peptide vaccines and durvalumab for treating breast cancer
|
|
CN106432202B
(zh)
*
|
2016-09-22 |
2019-04-02 |
郑州大学第一附属医院 |
喹唑啉类衍生物及其应用
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
AU2017335634A1
(en)
|
2016-09-27 |
2019-03-14 |
Cero Therapeutics, Inc. |
Chimeric engulfment receptor molecules
|
|
US10207998B2
(en)
|
2016-09-29 |
2019-02-19 |
Duke University |
Substituted benzimidazole and substituted benzothiazole inhibitors of transforming growth factor-β kinase and methods of use thereof
|
|
US10927083B2
(en)
|
2016-09-29 |
2021-02-23 |
Duke University |
Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase
|
|
CA3038712A1
(en)
|
2016-10-06 |
2018-04-12 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
WO2018078143A1
(en)
|
2016-10-28 |
2018-05-03 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Means and methods for determining efficacy of anti-egfr inhibitors in colorectal cancer (crc) therapy
|
|
WO2018081648A2
(en)
|
2016-10-29 |
2018-05-03 |
Genentech, Inc. |
Anti-mic antibidies and methods of use
|
|
TWI822055B
(zh)
|
2016-11-21 |
2023-11-11 |
台灣浩鼎生技股份有限公司 |
共軛生物分子、醫藥組成物及方法
|
|
CN110366550A
(zh)
|
2016-12-22 |
2019-10-22 |
美国安进公司 |
作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物
|
|
US12303505B2
(en)
|
2017-02-08 |
2025-05-20 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
TW201837467A
(zh)
|
2017-03-01 |
2018-10-16 |
美商建南德克公司 |
用於癌症之診斷及治療方法
|
|
US9980967B1
(en)
|
2017-03-16 |
2018-05-29 |
National Chiao Tung University |
Method for overcoming drug resistance of EGFR mutation and cancerous stemness of human non-small cell lung carcinoma
|
|
CN110505883A
(zh)
|
2017-04-13 |
2019-11-26 |
豪夫迈·罗氏有限公司 |
供治疗癌症的方法中使用的白介素-2免疫缀合物,cd40激动剂,和任选地pd-1轴结合拮抗剂
|
|
RU2019134940A
(ru)
|
2017-05-16 |
2021-06-16 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Лечение гепатоцеллюлярной карциномы
|
|
AU2018273356B2
(en)
|
2017-05-22 |
2021-09-16 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JP7760242B2
(ja)
|
2017-07-21 |
2025-10-27 |
ジェネンテック， インコーポレイテッド |
がんの治療法及び診断法
|
|
MX2020000903A
(es)
|
2017-08-11 |
2020-07-22 |
Genentech Inc |
Anticuerpos anti-cd8 y usos de los mismos.
|
|
KR102811888B1
(ko)
|
2017-09-08 |
2025-05-27 |
에프. 호프만-라 로슈 아게 |
암의 진단 및 치료 방법
|
|
AU2018329920B2
(en)
|
2017-09-08 |
2022-12-01 |
Amgen Inc. |
Inhibitors of KRAS G12C and methods of using the same
|
|
EP4714966A2
(en)
|
2017-09-26 |
2026-03-25 |
Cero Therapeutics Holdings, Inc. |
Chimeric engulfment receptor molecules and methods of use
|
|
WO2019083960A1
(en)
|
2017-10-24 |
2019-05-02 |
Oncopep, Inc. |
PEPTIDE VACCINES AND HDAC INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA
|
|
EP3700575A1
(en)
|
2017-10-24 |
2020-09-02 |
Oncopep, Inc. |
Peptide vaccines and pembrolizumab for treating breast cancer
|
|
US11369608B2
(en)
|
2017-10-27 |
2022-06-28 |
University Of Virginia Patent Foundation |
Compounds and methods for regulating, limiting, or inhibiting AVIL expression
|
|
CN109721552B
(zh)
*
|
2017-10-30 |
2022-09-20 |
上海北卡医药技术有限公司 |
一种吉非替尼的制备方法
|
|
TW201923089A
(zh)
|
2017-11-06 |
2019-06-16 |
美商建南德克公司 |
癌症之診斷及治療方法
|
|
WO2019099311A1
(en)
|
2017-11-19 |
2019-05-23 |
Sunshine Lake Pharma Co., Ltd. |
Substituted heteroaryl compounds and methods of use
|
|
EP3727387A4
(en)
|
2017-12-18 |
2021-12-15 |
Sterngreene, Inc. |
PYRIMIDINE COMPOUNDS USEFUL AS TYROSINE KINASE INHIBITORS
|
|
US11602534B2
(en)
|
2017-12-21 |
2023-03-14 |
Hefei Institutes Of Physical Science, Chinese Academy Of Sciences |
Pyrimidine derivative kinase inhibitors
|
|
AU2019207535B2
(en)
|
2018-01-15 |
2021-12-23 |
Epiaxis Therapeutics Pty Ltd |
Agents and methods for predicting response to therapy
|
|
KR102737185B1
(ko)
|
2018-01-20 |
2024-12-05 |
선샤인 레이크 파르마 컴퍼니 리미티드 |
치환된 아미노피리미딘 화합물 및 이의 사용 방법
|
|
CR20250117A
(es)
|
2018-01-26 |
2025-05-09 |
Exelixis Inc |
COMPUESTOS PARA EL TRATAMIENTO DE TRASTORNOS DEPENDIENTES DE CINASAS (Divisional 2020-0355)
|
|
CN117402114A
(zh)
|
2018-01-26 |
2024-01-16 |
埃克塞里艾克西斯公司 |
用于治疗激酶依赖性病症的化合物
|
|
CA3088198A1
(en)
|
2018-01-26 |
2019-08-01 |
Exelixis, Inc. |
Compounds for the treatment of kinase-dependent disorders
|
|
CN111836831A
(zh)
|
2018-02-26 |
2020-10-27 |
豪夫迈·罗氏有限公司 |
用于抗tigit拮抗剂抗体和抗pd-l1拮抗剂抗体治疗的给药
|
|
CA3093969A1
(en)
|
2018-03-28 |
2019-10-03 |
Cero Therapeutics, Inc. |
Expression vectors for chimeric engulfment receptors, genetically modified host cells, and uses thereof
|
|
MX2020010241A
(es)
|
2018-03-28 |
2020-10-16 |
Cero Therapeutics Inc |
Composiciones de inmunoterapia celular y usos de las mismas.
|
|
EP3774906A1
(en)
|
2018-03-28 |
2021-02-17 |
Cero Therapeutics, Inc. |
Chimeric tim4 receptors and uses thereof
|
|
KR20210003780A
(ko)
*
|
2018-04-05 |
2021-01-12 |
스미토모 다이니폰 파마 온콜로지, 인크. |
Axl 키나제 억제제 및 그의 용도
|
|
EP3788053B1
(en)
|
2018-05-04 |
2024-07-10 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
CA3098574A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
CN108395410A
(zh)
*
|
2018-05-09 |
2018-08-14 |
日照市普达医药科技有限公司 |
一种苯胺喹唑啉化合物及其在抗肿瘤药物中的应用
|
|
MA52564A
(fr)
|
2018-05-10 |
2021-03-17 |
Amgen Inc |
Inhibiteurs de kras g12c pour le traitement du cancer
|
|
JP2021524744A
(ja)
|
2018-05-21 |
2021-09-16 |
ナノストリング テクノロジーズ，インコーポレイティド |
分子遺伝子シグネチャーとその使用方法
|
|
US11096939B2
(en)
|
2018-06-01 |
2021-08-24 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
CA3102279A1
(en)
|
2018-06-01 |
2019-12-05 |
Cornell University |
Combination therapy for pi3k-associated disease or disorder
|
|
CA3102136A1
(en)
|
2018-06-06 |
2019-12-12 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the s1p1 receptor
|
|
MX2020012204A
(es)
|
2018-06-11 |
2021-03-31 |
Amgen Inc |
Inhibidores de kras g12c para tratar el cáncer.
|
|
US11285156B2
(en)
|
2018-06-12 |
2022-03-29 |
Amgen Inc. |
Substituted piperazines as KRAS G12C inhibitors
|
|
WO2019241327A1
(en)
|
2018-06-13 |
2019-12-19 |
California Institute Of Technology |
Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
|
|
MY205645A
(en)
|
2018-06-23 |
2024-11-02 |
Genentech Inc |
Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
|
|
TW202504930A
(zh)
|
2018-06-27 |
2025-02-01 |
台灣浩鼎生技股份有限公司 |
用於糖蛋白工程的糖苷合成酶變體及其使用方法
|
|
WO2020018789A1
(en)
|
2018-07-18 |
2020-01-23 |
Genentech, Inc. |
Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent
|
|
US12220423B2
(en)
|
2018-07-24 |
2025-02-11 |
Hygia Pharmaceuticals, Llc |
Compounds, derivatives, and analogs for cancer
|
|
AU2019310590A1
(en)
|
2018-07-26 |
2021-01-14 |
Sumitomo Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|
|
EP3847154A1
(en)
|
2018-09-03 |
2021-07-14 |
F. Hoffmann-La Roche AG |
Carboxamide and sulfonamide derivatives useful as tead modulators
|
|
AU2019342099A1
(en)
|
2018-09-19 |
2021-04-08 |
Genentech, Inc. |
Therapeutic and diagnostic methods for bladder cancer
|
|
KR102739487B1
(ko)
|
2018-09-21 |
2024-12-10 |
제넨테크, 인크. |
3중-음성 유방암에 대한 진단 방법
|
|
CN113194954A
(zh)
|
2018-10-04 |
2021-07-30 |
国家医疗保健研究所 |
用于治疗角皮病的egfr抑制剂
|
|
US12404540B2
(en)
|
2018-10-17 |
2025-09-02 |
The University Of Queensland |
Epigenetic biomarker and uses therefor
|
|
EP3867646A1
(en)
|
2018-10-18 |
2021-08-25 |
F. Hoffmann-La Roche AG |
Diagnostic and therapeutic methods for sarcomatoid kidney cancer
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
|
|
AU2019384118B2
(en)
|
2018-11-19 |
2025-06-12 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
US12351571B2
(en)
|
2018-12-19 |
2025-07-08 |
Array Biopharma Inc. |
Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases
|
|
EP3898626A1
(en)
|
2018-12-19 |
2021-10-27 |
Array Biopharma, Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
|
|
AU2019401495B2
(en)
|
2018-12-20 |
2025-06-26 |
Amgen Inc. |
Heteroaryl amides useful as KIF18A inhibitors
|
|
MA54543A
(fr)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
Inhibiteurs de kif18a
|
|
JP7686559B2
(ja)
|
2018-12-20 |
2025-06-02 |
アムジエン・インコーポレーテツド |
Ｋｉｆ１８ａ阻害剤
|
|
JP2022513967A
(ja)
|
2018-12-20 |
2022-02-09 |
アムジエン・インコーポレーテツド |
Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド
|
|
US20220040324A1
(en)
|
2018-12-21 |
2022-02-10 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and kinase inhibitor
|
|
BR112021014662A2
(pt)
|
2019-02-01 |
2021-09-21 |
Glaxosmithkline Intellectual Property Development Limited |
Tratamentos de combinação para o câncer que compreendem belantamab mafodotin e um anticorpo anti ox40 e usos e métodos dos mesmos
|
|
CN113396230A
(zh)
|
2019-02-08 |
2021-09-14 |
豪夫迈·罗氏有限公司 |
癌症的诊断和治疗方法
|
|
CN113677994B
(zh)
|
2019-02-27 |
2025-09-09 |
外延轴治疗股份有限公司 |
用于评估t细胞功能和预测对疗法的应答的方法和药剂
|
|
WO2020176748A1
(en)
|
2019-02-27 |
2020-09-03 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies
|
|
MX2021010323A
(es)
|
2019-03-01 |
2021-12-10 |
Revolution Medicines Inc |
Compuestos bicíclicos de heterociclilo y usos de este.
|
|
MX2021010319A
(es)
|
2019-03-01 |
2021-12-10 |
Revolution Medicines Inc |
Compuestos biciclicos de heteroarilo y usos de estos.
|
|
WO2020223233A1
(en)
|
2019-04-30 |
2020-11-05 |
Genentech, Inc. |
Prognostic and therapeutic methods for colorectal cancer
|
|
CN114269376A
(zh)
|
2019-05-03 |
2022-04-01 |
豪夫迈·罗氏有限公司 |
用抗pd-l1抗体治疗癌症的方法
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
WO2020236947A1
(en)
|
2019-05-21 |
2020-11-26 |
Amgen Inc. |
Solid state forms
|
|
EP3990494A1
(en)
|
2019-06-26 |
2022-05-04 |
GlaxoSmithKline Intellectual Property Development Limited |
Il1rap binding proteins
|
|
CN112300279A
(zh)
|
2019-07-26 |
2021-02-02 |
上海复宏汉霖生物技术股份有限公司 |
针对抗cd73抗体和变体的方法和组合物
|
|
EP4007752B1
(en)
|
2019-08-02 |
2025-09-24 |
Amgen Inc. |
Kif18a inhibitors
|
|
EP4007753B1
(en)
|
2019-08-02 |
2025-09-24 |
Amgen Inc. |
Kif18a inhibitors
|
|
EP4007638A1
(en)
|
2019-08-02 |
2022-06-08 |
Amgen Inc. |
Pyridine derivatives as kif18a inhibitors
|
|
EP4007756B1
(en)
|
2019-08-02 |
2025-12-24 |
Amgen Inc. |
Kif18a inhibitors
|
|
TWI873176B
(zh)
|
2019-09-04 |
2025-02-21 |
美商建南德克公司 |
Ｃｄ８結合劑及其用途
|
|
WO2021043961A1
(en)
|
2019-09-06 |
2021-03-11 |
Glaxosmithkline Intellectual Property Development Limited |
Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy
|
|
WO2021046289A1
(en)
|
2019-09-06 |
2021-03-11 |
Glaxosmithkline Intellectual Property Development Limited |
Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and ipilimumab
|
|
JP2022551422A
(ja)
|
2019-09-26 |
2022-12-09 |
エグゼリクシス， インコーポレイテッド |
ピリドン化合物およびタンパク質キナーゼの調節における使用の方法
|
|
JP2022548978A
(ja)
|
2019-09-27 |
2022-11-22 |
ジェネンテック， インコーポレイテッド |
薬抗ｔｉｇｉｔ及び抗ｐｄ－ｌ１アンタゴニスト抗体を用いた処置のための投薬
|
|
EP4038097A1
(en)
|
2019-10-03 |
2022-08-10 |
Cero Therapeutics, Inc. |
Chimeric tim4 receptors and uses thereof
|
|
EP4048671B1
(en)
|
2019-10-24 |
2026-03-18 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
|
JP2023511472A
(ja)
|
2019-10-29 |
2023-03-20 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
がんの治療のための二官能性化合物
|
|
TW202132316A
(zh)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑
|
|
IL322454A
(en)
|
2019-11-04 |
2025-09-01 |
Revolution Medicines Inc |
ras inhibitors
|
|
AU2020377925A1
(en)
|
2019-11-04 |
2022-05-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
KR20220092580A
(ko)
|
2019-11-06 |
2022-07-01 |
제넨테크, 인크. |
혈액암의 치료를 위한 진단과 치료 방법
|
|
CA3156359A1
(en)
|
2019-11-08 |
2021-05-14 |
Adrian Liam Gill |
Bicyclic heteroaryl compounds and uses thereof
|
|
WO2021094379A1
(en)
|
2019-11-12 |
2021-05-20 |
Astrazeneca Ab |
Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
|
|
TW202130618A
(zh)
|
2019-11-13 |
2021-08-16 |
美商建南德克公司 |
治療性化合物及使用方法
|
|
JP2023501528A
(ja)
|
2019-11-14 |
2023-01-18 |
アムジエン・インコーポレーテツド |
Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成
|
|
WO2021097256A1
(en)
|
2019-11-14 |
2021-05-20 |
Cohbar, Inc. |
Cxcr4 antagonist peptides
|
|
JP7837865B2
(ja)
|
2019-11-14 |
2026-03-31 |
アムジエン・インコーポレーテツド |
Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改良合成法
|
|
EP4065231A1
(en)
|
2019-11-27 |
2022-10-05 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
WO2021119505A1
(en)
|
2019-12-13 |
2021-06-17 |
Genentech, Inc. |
Anti-ly6g6d antibodies and methods of use
|
|
CA3164995A1
(en)
|
2019-12-20 |
2021-06-24 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2021142026A1
(en)
|
2020-01-07 |
2021-07-15 |
Revolution Medicines, Inc. |
Shp2 inhibitor dosing and methods of treating cancer
|
|
WO2021148396A1
(en)
|
2020-01-20 |
2021-07-29 |
Astrazeneca Ab |
Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
|
|
TW202142230A
(zh)
|
2020-01-27 |
2021-11-16 |
美商建南德克公司 |
用於以抗ｔｉｇｉｔ拮抗體抗體治療癌症之方法
|
|
WO2021194481A1
(en)
|
2020-03-24 |
2021-09-30 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
WO2022050954A1
(en)
|
2020-09-04 |
2022-03-10 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
JP2023512023A
(ja)
|
2020-01-28 |
2023-03-23 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド |
併用療法及びその使用及び方法
|
|
WO2021177980A1
(en)
|
2020-03-06 |
2021-09-10 |
Genentech, Inc. |
Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist
|
|
WO2021233534A1
(en)
|
2020-05-20 |
2021-11-25 |
Pvac Medical Technologies Ltd |
Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof
|
|
WO2021185844A1
(en)
|
2020-03-16 |
2021-09-23 |
Pvac Medical Technologies Ltd |
Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof
|
|
EP4122925A4
(en)
*
|
2020-03-17 |
2024-04-17 |
Medshine Discovery Inc. |
Proteolysis regulator and method for using same
|
|
WO2021202959A1
(en)
|
2020-04-03 |
2021-10-07 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
CN115768890A
(zh)
|
2020-04-15 |
2023-03-07 |
加州理工学院 |
通过分子和物理启动对t细胞免疫疗法的热控制
|
|
EP4143345A1
(en)
|
2020-04-28 |
2023-03-08 |
Genentech, Inc. |
Methods and compositions for non-small cell lung cancer immunotherapy
|
|
CN118221596A
(zh)
*
|
2020-06-15 |
2024-06-21 |
山东新时代药业有限公司 |
一种吉非替尼的有机酸盐
|
|
AU2021293038A1
(en)
|
2020-06-16 |
2023-02-02 |
F. Hoffmann-La Roche Ag |
Methods and compositions for treating triple-negative breast cancer
|
|
KR20230024368A
(ko)
|
2020-06-18 |
2023-02-20 |
제넨테크, 인크. |
항-tigit 항체 및 pd-1 축 결합 길항제를 사용한 치료
|
|
IL299131A
(en)
|
2020-06-18 |
2023-02-01 |
Revolution Medicines Inc |
Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
|
|
US20230235408A1
(en)
|
2020-06-30 |
2023-07-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
|
|
EP4172628A1
(en)
|
2020-06-30 |
2023-05-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery
|
|
US11787775B2
(en)
|
2020-07-24 |
2023-10-17 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
JP2023536602A
(ja)
|
2020-08-03 |
2023-08-28 |
ジェネンテック， インコーポレイテッド |
リンパ腫のための診断及び治療方法
|
|
EP4192509A1
(en)
|
2020-08-05 |
2023-06-14 |
Ellipses Pharma Ltd |
Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor
|
|
WO2022036146A1
(en)
|
2020-08-12 |
2022-02-17 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
WO2022036265A1
(en)
|
2020-08-14 |
2022-02-17 |
Cero Therapeutics, Inc. |
Chimeric tim receptors and uses thereof
|
|
WO2022036287A1
(en)
|
2020-08-14 |
2022-02-17 |
Cero Therapeutics, Inc. |
Anti-cd72 chimeric receptors and uses thereof
|
|
WO2022036285A1
(en)
|
2020-08-14 |
2022-02-17 |
Cero Therapeutics, Inc. |
Compositions and methods for treating cancer with chimeric tim receptors in combination with inhibitors of poly (adp-ribose) polymerase
|
|
CA3193273A1
(en)
|
2020-08-27 |
2022-03-03 |
Enosi Therapeutics Corporation |
Methods and compositions to treat autoimmune diseases and cancer
|
|
WO2022047259A1
(en)
|
2020-08-28 |
2022-03-03 |
California Institute Of Technology |
Synthetic mammalian signaling circuits for robust cell population control
|
|
US20250195521A1
(en)
|
2020-09-03 |
2025-06-19 |
Revolution Medicines, Inc. |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
|
CA3194067A1
(en)
|
2020-09-15 |
2022-03-24 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
JP2023544450A
(ja)
|
2020-09-23 |
2023-10-23 |
エラスカ・インコーポレイテッド |
三環式ピリドン及びピリミドン
|
|
CN116406291A
(zh)
|
2020-10-05 |
2023-07-07 |
基因泰克公司 |
用抗fcrh5/抗cd3双特异性抗体进行治疗的给药
|
|
TW202237638A
(zh)
|
2020-12-09 |
2022-10-01 |
日商武田藥品工業股份有限公司 |
烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
|
|
WO2022133345A1
(en)
|
2020-12-18 |
2022-06-23 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
JP7849366B2
(ja)
|
2020-12-22 |
2026-04-21 |
キル・レガー・セラピューティクス・インコーポレーテッド |
Ｓｏｓ１阻害剤およびその使用
|
|
CN112321814B
(zh)
*
|
2020-12-30 |
2021-03-23 |
广州初曲科技有限公司 |
一种吉非替尼艾地苯醌轭合物的制备及用途
|
|
AU2022221124A1
(en)
|
2021-02-12 |
2023-08-03 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydroazepine derivatives for the treatment of cancer
|
|
CA3211063A1
(en)
|
2021-02-19 |
2022-08-25 |
Exelixis, Inc. |
Pyridone compounds and methods of use
|
|
AU2022227021A1
(en)
|
2021-02-26 |
2023-09-21 |
Kelonia Therapeutics, Inc. |
Lymphocyte targeted lentiviral vectors
|
|
TW202309052A
(zh)
|
2021-05-05 |
2023-03-01 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑
|
|
JP2024516450A
(ja)
|
2021-05-05 |
2024-04-15 |
レボリューション メディシンズ インコーポレイテッド |
共有結合性ｒａｓ阻害剤及びその使用
|
|
KR20240017811A
(ko)
|
2021-05-05 |
2024-02-08 |
레볼루션 메디슨즈, 인크. |
암의 치료를 위한 ras 억제제
|
|
KR20240026948A
(ko)
|
2021-05-25 |
2024-02-29 |
에라스카, 아이엔씨. |
황 함유 헤테로방향족 트리사이클릭 kras 억제제
|
|
WO2022266206A1
(en)
|
2021-06-16 |
2022-12-22 |
Erasca, Inc. |
Kras inhibitor conjugates
|
|
CN113527266A
(zh)
*
|
2021-06-23 |
2021-10-22 |
上海健康医学院 |
一种靶向fap的双氧水响应的前药及其制备方法与应用
|
|
CN113336742B
(zh)
|
2021-06-29 |
2022-05-10 |
山东金吉利新材料有限公司 |
一种马来酸吡咯替尼中间体的合成方法
|
|
AU2022315530A1
(en)
|
2021-07-20 |
2024-01-18 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their preparation, and uses
|
|
EP4376874B1
(en)
|
2021-07-28 |
2026-03-04 |
Cero Therapeutics Holdings, Inc. |
Chimeric tim4 receptors and uses thereof
|
|
TW202321261A
(zh)
|
2021-08-10 |
2023-06-01 |
美商伊瑞斯卡公司 |
選擇性ｋｒａｓ抑制劑
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
CN113845485B
(zh)
*
|
2021-10-22 |
2023-03-14 |
湖南中医药大学 |
氨基酸衍生物及其制备方法和应用
|
|
US12275745B2
(en)
|
2021-11-24 |
2025-04-15 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
US12110276B2
(en)
|
2021-11-24 |
2024-10-08 |
Genentech, Inc. |
Pyrazolo compounds and methods of use thereof
|
|
CN119212994A
(zh)
|
2021-12-17 |
2024-12-27 |
建新公司 |
作为shp2抑制剂的吡唑并吡嗪化合物
|
|
WO2023144127A1
(en)
|
2022-01-31 |
2023-08-03 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
KR20240156373A
(ko)
|
2022-03-07 |
2024-10-29 |
암젠 인크 |
4-메틸-2-프로판-2-일-피리딘-3-카르보니트릴의 제조 방법
|
|
JP2025510572A
(ja)
|
2022-03-08 |
2025-04-15 |
レボリューション メディシンズ インコーポレイテッド |
免疫不応性肺癌を治療するための方法
|
|
JP2025510910A
(ja)
|
2022-03-31 |
2025-04-15 |
アストラゼネカ・アクチエボラーグ |
癌の処置のための、ａｋｔ阻害剤との組み合わせにおける上皮成長因子受容体（ｅｇｆｒ）チロシンキナーゼ阻害剤
|
|
IL315770A
(en)
|
2022-04-01 |
2024-11-01 |
Genentech Inc |
Dosage for treatment with bispecific anti-FCRH5/anti-CD3 antibodies
|
|
JP2025517650A
(ja)
|
2022-05-11 |
2025-06-10 |
ジェネンテック， インコーポレイテッド |
抗ＦｃＲＨ５／抗ＣＤ３二重特異性抗体による処置のための投与
|
|
KR20250022049A
(ko)
|
2022-06-07 |
2025-02-14 |
제넨테크, 인크. |
항-pd-l1 길항제 및 항-tigit 길항제 항체를 포함하는, 폐암 치료의 효율을 결정하는 방법
|
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
CA3259492A1
(en)
|
2022-06-27 |
2024-01-04 |
Astrazeneca Ab |
COMBINATIONS INVOLVING EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER
|
|
AU2023305619A1
(en)
|
2022-07-13 |
2025-01-23 |
F. Hoffmann-La Roche Ag |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
KR20250040020A
(ko)
|
2022-07-19 |
2025-03-21 |
제넨테크, 인크. |
항-fcrh5/항-cd3 이중특이성 항체로 치료하기 위한 투약법
|
|
CN119816589A
(zh)
|
2022-08-02 |
2025-04-11 |
国立大学法人北海道大学 |
使用细胞器复合体改善细胞疗法的方法
|
|
JP2025526726A
(ja)
|
2022-08-11 |
2025-08-15 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
二環式テトラヒドロアゼピン誘導体
|
|
AU2023322638A1
(en)
|
2022-08-11 |
2024-11-28 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydrothiazepine derivatives
|
|
WO2024033457A1
(en)
|
2022-08-11 |
2024-02-15 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydrothiazepine derivatives
|
|
AU2023322637A1
(en)
|
2022-08-11 |
2024-11-14 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydrothiazepine derivatives
|
|
AU2023358792A1
(en)
|
2022-10-14 |
2025-04-17 |
Black Diamond Therapeutics, Inc. |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|
|
JP2025538859A
(ja)
|
2022-10-21 |
2025-12-02 |
公益財団法人川崎市産業振興財団 |
非吸着性またはスーパーステルス小胞
|
|
WO2024088808A1
(en)
|
2022-10-24 |
2024-05-02 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof
|
|
KR20250093336A
(ko)
|
2022-10-25 |
2025-06-24 |
제넨테크, 인크. |
다발성 골수종에 대한 치료 및 진단 방법
|
|
EP4665735A1
(en)
|
2023-02-17 |
2025-12-24 |
Erasca, Inc. |
Kras inhibitors
|
|
AU2024241633A1
(en)
|
2023-03-30 |
2025-11-06 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
AR132338A1
(es)
|
2023-04-07 |
2025-06-18 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
CR20250420A
(es)
|
2023-04-07 |
2025-11-20 |
Revolution Medicines Inc |
Inhibidores macrocíclicos de ras
|
|
CN121100123A
(zh)
|
2023-04-14 |
2025-12-09 |
锐新医药公司 |
Ras抑制剂的结晶形式
|
|
CN121464140A
(zh)
|
2023-04-14 |
2026-02-03 |
锐新医药公司 |
Ras抑制剂的结晶形式、含有其的组合物及其使用方法
|
|
TW202508595A
(zh)
|
2023-05-04 |
2025-03-01 |
美商銳新醫藥公司 |
用於ｒａｓ相關疾病或病症之組合療法
|
|
AU2024270495A1
(en)
|
2023-05-05 |
2025-10-09 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
KR20260021689A
(ko)
|
2023-06-08 |
2026-02-13 |
제넨테크, 인크. |
림프종 진단 및 치료 방법을 위한 대식세포 시그니처
|
|
WO2025024257A1
(en)
|
2023-07-21 |
2025-01-30 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
TW202515614A
(zh)
|
2023-08-25 |
2025-04-16 |
美商建南德克公司 |
治療非小細胞肺癌之方法及組成物
|
|
AU2024360465A1
(en)
|
2023-10-12 |
2026-04-09 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
TW202542151A
(zh)
|
2023-12-22 |
2025-11-01 |
美商銳格醫藥有限公司 |
Ｓｏｓ１抑制劑及其用途
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025176843A1
(en)
|
2024-02-21 |
2025-08-28 |
Ags Therapeutics Sas |
Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof
|
|
TW202547461A
(zh)
|
2024-05-17 |
2025-12-16 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026030464A1
(en)
|
2024-07-30 |
2026-02-05 |
Genentech, Inc. |
Dosage regimen for reducing cytokine release syndrome (crs) with anti-fcrh5/anti-cd3 bispecific antibodies in multiple myeloma therapy
|
|
WO2026030476A1
(en)
|
2024-07-30 |
2026-02-05 |
Genentech, Inc. |
Precision medicine for optimal dosage of combined therapies systems and methods of use thereof
|
|
WO2026050446A1
(en)
|
2024-08-29 |
2026-03-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026072904A2
(en)
|
2024-09-26 |
2026-04-02 |
Revolution Medicines, Inc. |
Compositions and methods for treating lung cancer
|