BRPI0307786B8 - composição farmacêutica, método para preparar a mesma, métodos para inibir a taxa de precipitação do agente da solução no trato gi, e para reduzir variabilidade inter-pacientes no que se refere à biodisponibilidade e/ou concentrações plásmáticas do agente, e, uso de um celulose éter solúvel em água ou de um éster de um celulose éter solúvel em água - Google Patents

composição farmacêutica, método para preparar a mesma, métodos para inibir a taxa de precipitação do agente da solução no trato gi, e para reduzir variabilidade inter-pacientes no que se refere à biodisponibilidade e/ou concentrações plásmáticas do agente, e, uso de um celulose éter solúvel em água ou de um éster de um celulose éter solúvel em água

Info

Publication number
BRPI0307786B8
BRPI0307786B8 BRPI0307786A BR0307786A BRPI0307786B8 BR PI0307786 B8 BRPI0307786 B8 BR PI0307786B8 BR PI0307786 A BRPI0307786 A BR PI0307786A BR 0307786 A BR0307786 A BR 0307786A BR PI0307786 B8 BRPI0307786 B8 BR PI0307786B8
Authority
BR
Brazil
Prior art keywords
water
cellulose ether
soluble cellulose
agent
ester
Prior art date
Application number
BRPI0307786A
Other languages
English (en)
Other versions
BR0307786A (pt
BRPI0307786B1 (pt
Inventor
De Matas Marcel
Davis Parker Michael
Richard Gellert Paul
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27767732&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0307786(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0204392A external-priority patent/GB0204392D0/en
Priority claimed from GB0212462A external-priority patent/GB0212462D0/en
Priority claimed from GB0213267A external-priority patent/GB0213267D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0307786A publication Critical patent/BR0307786A/pt
Publication of BRPI0307786B1 publication Critical patent/BRPI0307786B1/pt
Publication of BRPI0307786B8 publication Critical patent/BRPI0307786B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"composição farmacêutica, método para preparar a mesma, métodos para inibir a taxa de precipitação do agente da solução no trato gi, e para reduzir variabilidade inter-pacientes no que se refere à biodisponibilidade e/ou concentrações plasmáticas do agente, e, uso de um celulose éter solúvel em água ou de um éster de um celulose éter solúvel em água". uma composição farmacêutica compreendendo 4-(3<39>-cloro-4<39>fluoroanilino)-7-metóxi-6-(3-morfolino-propóxi)quinazolina ou um seu sal farmaceuticamente aceitável (o agente) e um celulose éter solúvel em água ou um éster de um celulose éter solúvel em água. o celulose éter solúvel em água ou éster de um celulose éter solúvel em água presente na composição inibe a taxa de precipitação do agente da solução.
BRPI0307786A 2002-02-26 2003-02-24 composição farmacêutica, método para preparar a mesma, métodos para inibir a taxa de precipitação do agente da solução no trato gi, e para reduzir variabilidade inter-pacientes no que se refere à biodisponibilidade e/ou concentrações plásmáticas do agente, e, uso de um celulose éter solúvel em água ou de um éster de um celulose éter solúvel em água BRPI0307786B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0204392.5 2002-02-26
GB0204392A GB0204392D0 (en) 2002-02-26 2002-02-26 Pharmaceutical compound
GB0212462.6 2002-05-30
GB0212462A GB0212462D0 (en) 2002-05-30 2002-05-30 Pharmaceutical compound
GB0213267A GB0213267D0 (en) 2002-06-11 2002-06-11 Pharmaceutical composition
GB0213267.8 2002-06-11
PCT/GB2003/000803 WO2003072139A1 (en) 2002-02-26 2003-02-24 Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative

Publications (3)

Publication Number Publication Date
BR0307786A BR0307786A (pt) 2004-12-07
BRPI0307786B1 BRPI0307786B1 (pt) 2018-03-13
BRPI0307786B8 true BRPI0307786B8 (pt) 2021-05-25

Family

ID=27767732

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0307786A BRPI0307786B8 (pt) 2002-02-26 2003-02-24 composição farmacêutica, método para preparar a mesma, métodos para inibir a taxa de precipitação do agente da solução no trato gi, e para reduzir variabilidade inter-pacientes no que se refere à biodisponibilidade e/ou concentrações plásmáticas do agente, e, uso de um celulose éter solúvel em água ou de um éster de um celulose éter solúvel em água

Country Status (30)

Country Link
US (2) US20050163835A1 (pt)
EP (1) EP1480679B1 (pt)
JP (1) JP4544863B2 (pt)
KR (2) KR101002374B1 (pt)
CN (1) CN1326569C (pt)
AR (1) AR038848A1 (pt)
AT (1) ATE362771T1 (pt)
AU (1) AU2003208444B2 (pt)
BR (1) BRPI0307786B8 (pt)
CA (1) CA2476587C (pt)
CO (1) CO5601038A2 (pt)
CY (1) CY1108026T1 (pt)
DE (1) DE60313956T2 (pt)
DK (1) DK1480679T3 (pt)
ES (1) ES2286406T3 (pt)
HK (1) HK1070585A1 (pt)
IL (2) IL163642A0 (pt)
IS (1) IS2462B (pt)
MX (1) MXPA04008307A (pt)
MY (1) MY135609A (pt)
NO (1) NO328658B1 (pt)
NZ (1) NZ534513A (pt)
PL (1) PL208114B1 (pt)
PT (1) PT1480679E (pt)
RU (1) RU2318518C2 (pt)
SA (1) SA03240043B1 (pt)
TW (1) TWI271193B (pt)
UA (1) UA76325C2 (pt)
UY (1) UY27682A1 (pt)
WO (1) WO2003072139A1 (pt)

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Also Published As

Publication number Publication date
DE60313956T2 (de) 2008-05-15
TWI271193B (en) 2007-01-21
JP4544863B2 (ja) 2010-09-15
MXPA04008307A (es) 2004-11-26
CN1638805A (zh) 2005-07-13
EP1480679B1 (en) 2007-05-23
IS7420A (is) 2004-08-24
DK1480679T3 (da) 2007-09-03
NO328658B1 (no) 2010-04-19
IL163642A0 (en) 2005-12-18
MY135609A (en) 2008-05-30
CN1326569C (zh) 2007-07-18
KR101002374B1 (ko) 2010-12-17
PT1480679E (pt) 2007-07-18
AU2003208444A1 (en) 2003-09-09
BR0307786A (pt) 2004-12-07
PL208114B1 (pl) 2011-03-31
IL163642A (en) 2007-07-24
CO5601038A2 (es) 2006-01-31
BRPI0307786B1 (pt) 2018-03-13
UY27682A1 (es) 2003-10-31
JP2005523293A (ja) 2005-08-04
CA2476587C (en) 2010-05-04
NZ534513A (en) 2007-04-27
US20090186890A1 (en) 2009-07-23
EP1480679A1 (en) 2004-12-01
RU2004129280A (ru) 2005-06-10
KR20040088524A (ko) 2004-10-16
ES2286406T3 (es) 2007-12-01
CY1108026T1 (el) 2013-09-04
DE60313956D1 (de) 2007-07-05
TW200304379A (en) 2003-10-01
UA76325C2 (uk) 2006-07-17
ATE362771T1 (de) 2007-06-15
HK1070585A1 (en) 2005-06-24
RU2318518C2 (ru) 2008-03-10
WO2003072139A1 (en) 2003-09-04
CA2476587A1 (en) 2003-09-04
IS2462B (is) 2008-11-15
SA03240043B1 (ar) 2007-05-06
AU2003208444B2 (en) 2006-10-26
NO20043866L (no) 2004-09-15
PL372215A1 (en) 2005-07-11
US20050163835A1 (en) 2005-07-28
KR20100090726A (ko) 2010-08-16
AR038848A1 (es) 2005-01-26

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